ライフサイエンスコーパス: IL-27

1 IL-27 alone was incapable of altering the effector funct

2 IL-27 also inhibited osteoblast apoptosis through increa

3 IL-27 and IL-10 levels are increased in the lung microen

4 IL-27 and its receptor mRNA are both upregulated in the

5 IL-27 efficiently induced IL-10 expression in CD4 T cell

6 IL-27 exerts protective effects in autoimmune diseases l

7 IL-27 inhibited the differentiation of podoplanin-expres

8 IL-27 is a cytokine of the IL-12 family that plays a key

9 IL-27 is a heterodimeric cytokine composed of the subuni

10 IL-27 is a pleiotropic member of the IL-6 and IL-12 cyto

11 IL-27 is frequently associated with suppressed inflammat

12 IL-27 is overproduced by tristetraprolin-deficient macro

13 IL-27 is predominantly synthesized by mononuclear phagoc

14 IL-27 regulates immune responses in inflammation.

15 IL-27 signaling in Tregs was necessary, as transferring

16 IL-27 signals through the widely expressed IL-27 recepto

17 IL-27 suppressed osteoclastogenesis in an Egr-2-dependen

18 IL-27 treatment in ovariectomized mice suppressed Th17 c

19 IL-27 treatment prevented the loss of trabecular micro-a

20 IL-27 was found to suppress in vitro Th17 and, to a less

21 IL-27, a multifunctional cytokine produced by APCs, anta

22 IL-27, IL-10, and inducible T-cell costimulator ligand s

23 IL-27- and IL-35-independent functions of EBI3 could com

24 IL-27-conditioned T helper 1 cells exhibit reduced effec

25 25 and down-regulation of IL-6, IL-9, IL-10, IL-27, IFNA4, CSF3, LOC100152038, and LOC100736831 at th

26 tion is associated with loss of IL-6, IL-11, IL-27, and OSM signaling but a largely intact LIF respon

27 ines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory facto

28 dendritic cell (DC) interleukin-12 (IL-12), IL-27, and IL-10 immunity than M68.

29 Thus, the balance of IL-23 vs IL-12/IL-27 signals into CD4(+) effector T cells determines wh

30 -1beta, IL-2, IL-4, IL-10, IL-12beta, IL-13, IL-27, and IFN-gamma genes were examined in 296 chronica

31 nflammatory (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and TGF-beta) cytokines following treatmen

32 y cytokines (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and transforming growth factor beta [TGF-b

33 ssociated with TCR engagement: IL-12, IL-18, IL-27, IL-9, IL-25, and TGF-beta1.

34 rferon-gamma (IFN-gamma) and interleukin 27 (IL-27) altered ILC2 function dependent on the transcript

35 We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of

36 upregulation by IFN-beta and interleukin-27 (IL-27) also increases the surface expression of Env and

37 s (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimm

38 Interleukin-27 (IL-27) and IL-37 are two known anti-inflammatory cytokin

39 hat plasma levels of soluble interleukin-27 (IL-27) are significantly elevated in individuals with hi

40 tients, we now show that low interleukin-27 (IL-27) expression corresponds with an increased incidenc

41 Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the subun

42 Interleukin-27 (IL-27) is an important cytokine in inflammatory diseases

43 immune-suppressive cytokine interleukin-27 (IL-27) is elevated in neonatal mice.

44 Interleukin-27 (IL-27) is known to control primary CD4(+) T cell respons

45 ture human DCs express functional IL-27R; 3) IL-27 exerts immunosuppressive activity by crippling the

46 ns and after pulsing with a viral Ag; and 4) IL-27 is chemotactic for human DCs.

47 ve IL-10 elicitors revealed that IL-2, IL-4, IL-27, IL-10, and neuromedin U (NMU) increased IL-10 pro

48 Th17 differentiation, whereas IL-27 or IL-6+IL-27 induced p-STAT3/p-STAT1 ratios < 1, resulting in i

49 es (eg, interleukin-12 [IL-12], IL-23, IL-6, IL-27, IL-10, transforming growth factor-beta) that expa

50 Additionally, IL-27 regulated the expression of B7-H4 on HIV MDSC, and

51 ful for a beneficial manipulation of adverse IL-27(p28) release during sepsis.

52 Although IL-27 treatment does not affect expression of macrophage

53 Thus, our data identify an IL-27/NFIL3 signalling axis as a key regulator of effect

54 ds to CXCR5(+) CD8(+) T cell expansion in an IL-27- and STAT1-dependent manner.

55 subset of CD4(+) cells, the Tr1 cells, in an IL-27-dependent manner in vitro and in vivo.

56 generation and expansion of Th17 cells in an IL-27-dependent manner, it is unclear how pathogenic Th1

57 of immunosuppressive IL-10 is promoted in an IL-27-independent manner.

58 Using an IL-27 reporter transgenic mouse model, we show in this s

59 ater immediate rise in IL-10 (P = 0.003) and IL-27 (P = 0.04) mRNA levels.

60 ory immunity and further highlight IL-10 and IL-27 as potent therapeutic targets.

61 by induction of interleukin-10 (IL-10)- and IL-27-mediated mechanisms.

62 ls in the small intestine through IL-10- and IL-27-producing dendritic cells.

63 AT1 activation profiles for IL-6, IL-21, and IL-27, as well as for cytokine pairs over time.

64 everal cytokines, including IL-6, IL-21, and IL-27, each of these cytokines has a very different effe

65 a, IL-2, IL-33, TNF-alpha, IL-21, IL-22, and IL-27), from cell-sorted purified CD4+ and CD8+ T cells

66 roup of related cytokines: IL-12, IL-23, and IL-27.

67 Immunotherapy targeting PD-1, CTLA-4, and IL-27 blocked CD4(+) T cell exhaustion during malaria in

68 ap of the transcriptomes induced by IL-6 and IL-27 and few examples in which the cytokines acted in o

69 Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and emplo

70 onse to IFN-gamma, interleukin-6 (IL-6), and IL-27.

71 that in addition to IFN-alpha, IFN-beta and IL-27 also affect Vpu-mediated BST-2 downregulation and

72 n C. parapsilosis, TLR7, NOD2, IFN-beta, and IL-27, and we have identified an important role for IL-2

73 roduction of IL-10 by regulatory B cells and IL-27-mediated suppression of lymphoid follicle formatio

74 ified key roles for macrophage IFN-gamma and IL-27 in the regulation of RSV-induced exacerbation of a

75 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-g

76 s highlight critical roles for IFN-gamma and IL-27, downstream of TNF-alpha and MCP-1, in the mechani

77 , IL-13, and IL-17, it induced IFN-gamma and IL-27.

78 P-1 induced expression of both IFN-gamma and IL-27.

79 ansion in the lungs; however, type I IFN and IL-27 have nonredundant roles supporting pulmonary CD8(+

80 weeks postinfection, IL-12, type 1 IFN, and IL-27 were all required for efficient CD8(+) T cell expa

81 fect disease outcome: IL-12, type I IFN, and IL-27.

82 s following parasite antigen stimulation and IL-27 or IL-37 neutralization.

83 e, which generates T-cell responses that are IL-27-independent.

84 IFN-beta, IL-27, and IL-10 have been shown to exert a range of sim

85 genic phenotype, expressing IL-10, TGF-beta, IL-27, and aldehyde dehydrogenase 1A2 but not IL-12 or I

86 ther suggest a complex interrelation between IL-27 and IL-6.

87 eprosy skin lesions suggested a link between IL-27 and the IFN-beta induced IL-10 pathway.

88 s shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over

89 4(+) T cells was partially regulated by both IL-27 and type I IFN signaling.

90 lexible inter-alpha helix loop, and HA-bound IL-27 retained biological activity.

91 M. leprae to induce IL-10 was diminished by IL-27 knockdown.

92 Suppression of Th17-biased EAE by IL-27 is IL-10-independent, in contrast to its mechanism

93 ed for the suppression of Th17-biased EAE by IL-27, in sharp contrast to Th1-biased EAE.

94 the enhanced potential for ROS generation by IL-27.

95 ha or Lag3, a downstream molecule induced by IL-27, was unable to protect mice from experimental auto

96 te IL-10 secretion from Tr1 cells induced by IL-27.

97 acrophages, the frequency of F4/80(+)CD11b(+)IL-27(p28)(+) cells was reduced by the addition of IL-10

98 tudy that conventional type 1 dendritic cell IL-27 production in the draining lymph node 12 h after s

99 IL-23 counteracts IL-27 and IL-12-mediated effects on Tr-1-development rei

100 macrophage-derived immunoregulatory cytokine IL-27 was identified in modulating Th2 inflammation foll

101 expression of the anti-inflammatory cytokine IL-27 in response to infection.

102 The cytokine IL-27 has been shown to limit immune-mediated pathology

103 BI3) is a subunit of the composite cytokines IL-27 and IL-35.

104 nd the resulting production of the cytokines IL-27, IL-15, and IL-10.

105 Systemically delivered IL-27 efficiently prevents the development of experiment

106 ytokines, Treg-derived IL-35 and APC-derived IL-27, both capable of suppressing Th17 cells and regula

107 ing influenza infection myeloid cell-derived IL-27 regulates the early-phase effector functions of NK

108 At the site of disease, IL-27 was more strongly expressed in skin lesions of pat

109 n irreplaceable contribution of Tregs during IL-27-mediated control of inflammation.

110 These data suggest that endogenous IL-27 acts at several points in the inflammatory cascade

111 human cord blood-derived macrophages express IL-27 genes and secrete more cytokine than macrophages f

112 9, CD28, and CD40L; differentially expressed IL-27 and IL-10 anti-inflammatory cytokines; spontaneous

113 IL-27 signals through the widely expressed IL-27 receptor (IL-27R), composed of the ligand-specific

114 es during inflammatory disorders, but so far IL-27 has not been defined as a part of these multifacet

115 and decreased production of IL-10 following IL-27 and IL-37 neutralization and parasite antigen stim

116 s stimulated with parasite antigen following IL-27 or IL-37 neutralization.

117 y IL-10 as a critical suppressing factor for IL-27(p28) production during infection-associated inflam

118 his study describes a regulatory pathway for IL-27 expression and cytotoxic T lymphocyte function med

119 a reveal a previously unappreciated role for IL-27 in modulating CD4(+) T cell chemotactic pathways d

120 the first time establishes a novel role for IL-27 in regulating early-phase effector functions of NK

121 a suggest a previously unrecognized role for IL-27 in regulating epithelial cell proliferation and an

122 and we have identified an important role for IL-27 in the immune response against C. parapsilosis Ove

123 nd healing, suggesting an essential role for IL-27 signaling in skin regeneration in vivo.

124 ild-type mice, suggesting a limited role for IL-27.

125 nodes, macrophages are the major source for IL-27; 2) immature and mature human DCs express function

126 L-27Ralpha)(-/-) mice that lack a functional IL-27 receptor.

127 Functionally, IL-27 inhibited the ability of IFN-gamma to trigger anti

128 Furthermore, IL-27-induced STAT1-deficient T cells were indistinguish

129 eful by binding free p28 and p35 to generate IL-27 and IL-35.

130 we unveil key molecular mechanisms governing IL-27 biogenesis, an IL-12 family member that limits inf

131 Heterodimeric IL-27 (p28/EBV-induced gene 3) is an important member of

132 The effects of heterodimeric IL-27 (p28/EBI3) have been implicated in the natural cou

133 tokine, whereas in humans only heterodimeric IL-27 is present.

134 However, IL-27 sensitizes NK cells to augment both in vitro and i

135 udy forms a strong basis for using humanized IL-27 toward the treatment of post-menopausal osteoporos

136 antiretroviral treatment, and they identify IL-27 and its specific receptor as a critical immune axi

137 h that beta subunit of IL-27 (Ebi)(-/-) (ie, IL-27-incompetent) DC-RAs were ineffective in inducing f

138 ibuting to regulation of antitumour immunity.IL-27 is one of a number of cytokines that can induce an

139 y variable group, we detected immunoreactive IL-27 (953 +/- 504 pg/mg lysate), a mediator not previou

140 own about the factors that negatively impact IL-27 expression.

141 ith increased mortality that was improved in IL-27 receptor alpha (IL-27Ralpha)(-/-) mice that lack a

142 Although the mechanisms involved in IL-27 induction are well studied, much less is known abo

143 nd in polarizing immune responses, including IL-27 that exerts pro- and anti-inflammatory functions.

144 Increased IL-27 levels were consistent with increased mortality th

145 tly, C5aR-deficient mice exhibited increased IL-27 expression and fewer Th17 cells and consequently d

146 FN-alpha/beta receptor and STAT1/2 to induce IL-27.

147 ct of dexamethasone on LPS/IFN-gamma-induced IL-27 mRNA and protein levels in the macrophage cell lin

148 lone failed to inhibit LPS/IFN-gamma-induced IL-27 production and AHR in mice.

149 d sensitivity to block LPS/IFN-gamma-induced IL-27 production and AHR via its antioxidative property.

150 e, we found that C5a inhibited IFN-I-induced IL-27 production from macrophages of lupus subjects.

151 ous immune responses to microbial infection, IL-27 contributes to the suppression of host antimicrobi

152 ry IL-12 and IL-23 and the anti-inflammatory IL-27 and IL-35 cytokines.

153 P, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negativ

154 (IL-12) and IL-23 production, but inhibiting IL-27 during EAE.

155 trong induction (IL-6) to strong inhibition (IL-27).

156 natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a pot

157 on to bone marrow-derived DCs, PGE2 inhibits IL-27 production in macrophages and in splenic cDC, and

158 PGE2 We showed previously that PGE2 inhibits IL-27 production in murine bone marrow-derived DCs.

159 Interestingly, IL-27 was indispensable for the prevention of colitis by

160 We found that CD8(+) T cell-intrinsic IL-27 signaling safeguards the ability of TCF1(hi) cells

161 o describe the impact of elevated early-life IL-27 on the host response in a neonatal infection model

162 his provides the basis for a more human-like IL-27 system in mice and establishes a secretion-compete

163 LL-IL-27 administration protected mice from T-cell transfer

164 LL-IL-27 also reduced colitis in mice after administration

165 LL-IL-27 also reduced the numbers of CD4(+) and IL-17(+) T

166 LL-IL-27 reduced disease activity scores, pathology feature

167 LL-IL-27 reduces colitis in mice by increasing the producti

168 LL-IL-27 was more effective than either LL-IL-10 or systemi

169 food-grade bacterium Lactococcus lactis (LL-IL-27), and tested its ability to reduce colitis in mice

170 mice to induce colitis; 7.5 weeks later, LL-IL-27 was administered to mice via gavage.

171 Mucosal delivery of LL-IL-27 could be a more effective and safer therapy for in

172 The effects of LL-IL-27 required production of IL-10 by the transferred T

173 Manipulating IL-27 may provide a novel therapeutic strategy for the t

174 Mechanistically, IL-27 endowed rapidly dividing cells with IRF1, a transc

175 Mechanistically, IL-27 feeds back on keratinocytes to stimulate cell prol

176 on murine macrophages blocked IFN-I-mediated IL-27 production, thus permitting the development of Th1

177 The 2 genes encoding mouse IL-27 were synthesized with optimal codon use for L lact

178 We observed IL-27 binding to HA, in accordance with previous studies

179 After unilateral ureteral obstruction, IL-27 deficiency resulted in increased tissue injury and

180 Abrogation of IL-27 signaling did not affect virus-specific CD8+ T cel

181 The absence of IL-27 signaling accelerated virus control within the CNS

182 Although the activity of IL-27 is well characterized in murine immune cells, only

183 underlying the immunosuppressive activity of IL-27, suggesting that this cytokine may function as a h

184 T cells (Tregs) are the main target cells of IL-27, mediating its immunoregulatory functions in vivo.

185 8, independent of its role as a component of IL-27, can act as a negative regulator of humoral and ce

186 As a component of IL-27, IL-27p28 is critical to limit infection-induced T

187 esulted in 3-5-fold higher concentrations of IL-27(p28) in endotoxic shock and polymicrobial sepsis.

188 Contributions of IL-27 to viral pathogenesis were evaluated by infection

189 Importantly, deletion of IL-27 receptor WSX-1 in tristetraprolin-deficient mice (

190 Genetic disruption of IL-27 signaling enhanced the respiratory burst of macrop

191 ed at investigating whether dysregulation of IL-27 expression and function may be involved in pathoge

192 In this report, we study the effect of IL-27 supplementation on ovariectomized estrogen-deficie

193 kage led to an increase in the expression of IL-27 subunits p28 and EBI-3 in the lungs and lymph node

194 DC-RA expression of IL-27 was important to their induction of CD25(+) lympho

195 This 'priming' function of IL-27 is mediated partly via transcriptional pathways re

196 infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helmin

197 ghlight the unexpected central importance of IL-27 in the generation of robust, high-affinity cellula

198 e have examined the functional importance of IL-27 receptor (IL-27R) signaling in regulating the form

199 l allergic asthma, we show that induction of IL-27 by R848 is critical for the observed ameliorative

200 r Candida parapsilosis-mediated induction of IL-27 in a TLR7-, MyD88-, and NOD2-dependent manner.

201 IFN-beta, STAT1, or STAT2, and inhibition of IL-27 does not appear to be mediated through PKA, exchan

202 propose that the PGE2-induced inhibition of IL-27 in activated cDC represents an important additiona

203 ges completely interrupted the inhibition of IL-27(p28) by IL-10 after TLR4 activation.

204 rface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically

205 d CNS tissues is not affected by the lack of IL-27 signaling in Tregs, suggesting a functional defect

206 kidney disease had elevated serum levels of IL-27 and IL-17A, whereas expression of transcripts for

207 Levels of IL-27 in vitro and in vivo were examined and mouse AHR w

208 rk, we hypothesized that increased levels of IL-27 predispose neonatal mice to more severe infection

209 The underlying mechanism of IL-27 functions has long been attributed to its ability

210 neuroendocrine system for the modulation of IL-27-dependent acute inflammation.

211 Neutralization of IL-27 completely reversed the therapeutic effect of R848

212 Furthermore, neutralization of IL-27 resulted in more severe colitis in infected IL-10-

213 y, and shifted the transcriptional output of IL-27 from STAT1 to STAT3.

214 eliorate the disease even in the presence of IL-27-responsive conventional CD4 T cells.

215 sing cells as the most abundant producers of IL-27 during infection.

216 In vitro, R848 induced production of IL-27 by murine alveolar macrophages and dendritic cells

217 regulation of gene expression and release of IL-27 in sepsis are poorly understood.

218 yD88-dependent and TRIF-dependent release of IL-27(p28).

219 The functional role of IL-27 and CD301b(+) cells is demonstrated by the finding

220 We therefore wanted to examine the role of IL-27 and IL-37 in regulating CD4(+) and CD8(+) T cell r

221 e data provide evidence of a central role of IL-27 for the control of Th2-mediated allergic diseases.

222 To explore the precise role of IL-27 in CAD, we investigated the genetic association be

223 Based on the anti-inflammatory role of IL-27 in cDC and through the generation of Tr1 cells, we

224 ogy, these data define a detrimental role of IL-27 in promoting demyelination by delaying viral contr

225 indings uncover a previously unknown role of IL-27 in regulating Treg function to control autoimmune

226 This study investigates the role of IL-27 signaling in respiratory syncytial virus (RSV) inf

227 in the spleen may be a significant source of IL-27(p28) during sepsis.

228 le regarding the natural cellular sources of IL-27 in humans and its effects on human immune cells.

229 T cells in vitro, such that beta subunit of IL-27 (Ebi)(-/-) (ie, IL-27-incompetent) DC-RAs were ine

230 ied the events regulating the p28 subunit of IL-27 in endotoxic shock and polymicrobial sepsis follow

231 Supplementation of IL-27 activates Egr-2 to induce IL-10 producing Tr1 cell

232 Targeting of IL-27 therefore represents a novel strategy for the in v

233 s inhibits IRF-1-mediated transactivation of IL-27 gene expression via the PI3K/Akt pathway.

234 sed vaccine adjuvants unexpectedly depend on IL-27 for eliciting CD4(+) and CD8(+) T-cell responses.

235 ssion of experimental asthma is dependent on IL-27.

236 g dependence of R848-mediated suppression on IL-27.

237 how that p28 did not interfere with IL-6- or IL-27-induced signaling, indicating that p28 has no anta

238 esistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced steroid-resis

239 Lack of IL-27R (Il27ra(-/-)) or IL-27 (Ebi3(-/-)) resulted in impaired NK cell effector

240 ed STAT activation, at low molar excess over IL-27.

241 10 or systemic administration of recombinant IL-27 in reducing colitis in mice.

242 ally, systemic administration of recombinant IL-27 in Treg-specific Il27ra(-/-) mice fails to amelior

243 lly, treatment of monocytes with recombinant IL-27 was sufficient to induce the production of IL-10.

244 he transcription factor FOSL1, which reduced IL-27 and TNFalpha production by monocytes.

245 Serum IL-27 levels continued to rise during infection.

246 otic subjects where we found decreased serum IL-27 levels along with reduced Egr-2 expression.

247 contrast to viral infections at other sites, IL-27 does not play a proinflammatory role during JHMV-i

248 Moreover, soluble IL-27 plasma levels are negatively associated with the b

249 L-27, gene expression levels of the specific IL-27 receptor (IL27RA) in PBMC correlated directly with

250 ro; however, we found no evidence supporting IL-27-induced IL-10 induction in CD4 T cells in vivo.

251 ast, IL-10 remained fully active to suppress IL-27(p28) with deletion of SOCS3 in Tie2-Cre/SOCS3flox

252 Tristetraprolin suppresses IL-27 production by promoting p28 mRNA degradation.

253 Peripheral tissue analysis revealed systemic IL-27 expression, while myeloid cell profiling identifie

254 Thus, we demonstrate that IL-27 and IL-37 limit the induction of particular T cell

255 marrow chimera experiments demonstrate that IL-27 dependency is T cell-intrinsic, requiring T-cell e

256 In contrast, our findings demonstrate that IL-27 indirectly promotes an inflammatory cytokine respo

257 y of inflammation, our data demonstrate that IL-27 is a potent regulator of ROS induction and may be

258 blot and knock down assays demonstrate that IL-27 is able to enhance the potential of superoxide pro

259 We also demonstrate that IL-27 is able to induce extracellular superoxide dismuta

260 In this study, we demonstrate that IL-27 is rapidly and transiently produced by CD301b(+) c

261 We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HI

262 ping reporter mice further demonstrates that IL-27 signaling in Tregs may control stability of Foxp3

263 We find that IL-27 signaling suppresses splenic CD4(+) T cell CCR5-de

264 We also found that IL-27, which shares the EBI3 subunit with IL-35, promote

265 Finally, we identify that IL-27 potently increases expression of the antiviral oli

266 Chinese Han population, which indicated that IL-27 might only be an inflammatory marker during the de

267 t in CD4(+) or CD8(+) Tregs, indicating that IL-27 inhibition had differential effects on IL-10 produ

268 eg-specific Il27ra(-/-) mice, we report that IL-27 signaling in Foxp3(+) Tregs is essential for Tregs

269 These findings reveal that IL-27 opposes IFN-I to uncouple effector differentiation

270 Our data reveal that IL-27 or IL-37 neutralization resulted in significantly

271 Further, we show that IL-27 dependency not only dictates the magnitude of vacc

272 Consistent with these findings, we show that IL-27 induces sufficient p-STAT3 to promote Th17 differe

273 In this article, we show that IL-27, another IL-12 family member, is produced by myelo

274 -associated colitis and further suggest that IL-27 may be a critical factor for controlling intestina

275 Collectively, our results suggest that IL-27 represents a therapeutic target to limit susceptib

276 ntiation from cell division and suggest that IL-27 signaling could be exploited to augment self-renew

277 The IL-27 polyglutamic acid domain is located in a flexible

278 g in HIV control and especially identify the IL-27/IL-27 receptor subunit alpha (IL-27RA) axis as a p

279 ELS was also noted in mice deficient in the IL-27 receptor (IL-27R) after the onset of inflammatory

280 Furthermore, genetic ablation of the IL-27 receptor (Il27Ra(-/-)) attenuates wound healing, s

281 We further show that the IL-27/NFIL3 signalling axis is crucial for the induction

282 he subunits IL-27p28 and EBi3, and while the IL-27 heterodimer influences T cell activities, there is

283 ystemically during malaria infection through IL-27 receptor signaling that is supported after CD4(+)

284 Thus, IL-27 appears to negatively regulate ELS development in

285 Thus, IL-27 functions as a regulatory cytokine during RSV path

286 Thus, IL-27 signaling in DCs limited pathogenic T cell respons

287 Neutralizing Abs to IL-27(p28) improved survival rates, restricted cytokine

288 In addition to IL-27, gene expression levels of the specific IL-27 rece

289 f the sympathetic nervous system) related to IL-27 production in primary mouse macrophages.

290 Pre-committed Th17 cells respond to IL-27 and IL-12 by upregulating Blimp1 and adopt a Tr-1-

291 e in vivo, which could be rescued by topical IL-27 treatment.

292 Unexpectedly, IL-27 did not inhibit HIV-1 in T cell lines, whereas IL-

293 Combined LPS/IFN-gamma strongly upregulates IL-27 production, which has been linked to steroid-resis

294 Moreover, in vitro IL-27 enhanced secretion of IFN-gamma whereas it inhibit

295 s were the source of secreted IL-35, whereas IL-27 production by CD11c(+) cells was inhibited.

296 e promotion of Th17 differentiation, whereas IL-27 or IL-6+IL-27 induced p-STAT3/p-STAT1 ratios < 1,

297 nd re-epithelialization in the skin, whereas IL-27 leads to suppression of keratinocyte terminal diff

298 In this study we asked whether IL-27 is produced by human secondary lymphoid organs and

299 ype I and type II interferons, together with IL-27, regulate ILC2 cells to restrict type 2 immunopath

300 F were induced early on after treatment with IL-27 and were required for the differentiation and func