ライフサイエンスコーパス: ILF

1 ILF development was profoundly arrested in the absence o

2 ILF formation occurs in the absence of T lymphocytes and

3 Although ILF bound constitutively to the IL-2 promoter, it was no

4 -lateral preoccipital region projects via an ILF-SLF pathway to frontal area 8Av.

5 mscribed regions of the FF, PWMB, UF, AF and ILF.

6 nhemopoietic stromal cell networks in CP and ILF of adult mice also expressed FDC-M1, CD157 (BP-3), a

7 dentified VCAM-1(+) cells within both CP and ILF that are candidates for the stromal cells involved i

8 ce resulted in reconstitution of both CP and ILF.

9 r transfer to CD132-null mice lacking CP and ILF.

10 sional flow cytometry, we found that CP- and ILF-associated CD11c(+) cells were a transcriptionally d

11 CIA-DCs required programming by CP- and ILF-resident CCR6(+) ILC3 via lymphotoxin-beta receptor

12 lesion in the location of the right IFOF and ILF.

13 and Ag-specific B lymphocyte responses, and ILF B lymphocytes express elevated levels of LT in the a

14 ient to restore the organization of CLPs and ILFs and host defense against infection with C. rodentiu

15 anization and maintenance of mature CLPs and ILFs in the colon during infection with Citrobacter rode

16 The outer surface of CPs and ILFs is demarcated by a poorly characterized population

17 s) are components of cryptopatches (CPs) and ILFs and were therefore evaluated in this process.

18 Cs, whereas LTi-like ILCs, cryptopatches and ILFs were partially dependent on Notch signaling.

19 We also observed associations between ILF and fornix microstructure and category-selective BOL

20 sequences in the IL-2 promoter are bound by ILF and that this binding may be involved in the control

21 ontains clusters of DCs restricted to the CP/ILF continuum.

22 isual anatomy; (ii) the tractography-defined ILF is structurally distinct from fibres of the optic ra

23 ssential for their entry into the developing ILFs.

24 While the function of the direct ILF pathway is unclear, it appears to mediate the fast t

25 We observed that diverse ILF cellular populations express alpha(4)beta(7) and alp

26 ription factor IL-2 enhancer binding factor (ILF) is constitutively expressed in both resting and act

27 rt that interleukin enhancer binding factor (ILF)3, a double-stranded RNA binding protein, associates

28 eyed via the inferior longitudinal fascicle (ILF) to the parietal lobe (areas POa and IPd), superior

29 (MCP), the inferior longitudinal fasciculi (ILF), inferior frontooccipital fasciculi (IFOF), genu (G

30 d the right inferior longitudinal fasciculi (ILF).

31 the right inferior longitudinal fasciculus (ILF) (P = .0008).

32 the right inferior longitudinal fasciculus (ILF) and left forceps major (>/=164mul, p<.01) than age-

33 er tracts [inferior longitudinal fasciculus (ILF) and/or inferior fronto-occipital fasciculus (IFOF)]

34 s (AF) and inferior longitudinal fasciculus (ILF) as fiber tracts that connect regions already implic

35 s (UF) and inferior longitudinal fasciculus (ILF)).

36 ulus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF) and cingulum bundle (CB).

37 uced FA in inferior longitudinal fasciculus (ILF).

38 ent of the inferior longitudinal fasciculus (ILF).

39 the right inferior longitudinal fasciculus (ILF).

40 belled the inferior longitudinal fasciculus (ILF).

41 ructure of inferior longitudinal fasciculus (ILF, connecting occipital and ventro-anterior temporal l

42 the right superior longitudinal fasciculus, ILF, and forceps minor (>/= 164mul, p<.01).

43 l intestine, the isolated lymphoid follicle (ILF).

44 opment of CP or isolated lymphoid follicles (ILF) after transfer to CD132-null mice lacking CP and IL

45 atches (CP) and isolated lymphoid follicles (ILF) in the small intestine of C57BL/6 mice.

46 Isolated lymphoid follicles (ILFs) are organized lymphoid structures that facilitate

47 Isolated lymphoid follicles (ILFs) are recently appreciated members of the mucosal im

48 ches (CLPs) and isolated lymphoid follicles (ILFs) are two main lymphoid structures in the colon.

49 tches (CPs) and isolated lymphoid follicles (ILFs) constitute steady-state activation hubs containing

50 e is lined with isolated lymphoid follicles (ILFs) that facilitate sampling of luminal antigens to el

51 yptopatches and isolated lymphoid follicles (ILFs), but not embryonically 'imprinted' Peyer's patches

52 transform into isolated lymphoid follicles (ILFs), which subsequently act as sites for the generatio

53 mphoid tissues, isolated lymphoid follicles (ILFs).

54 ch of the two sequence elements required for ILF binding decreased IL-2 promoter activity when assaye

55 beta receptor-dependent events required for ILF formation can occur in adulthood and require LT-suff

56 examine the nature and factors required for ILF formation.

57 re the influx of B220+ B lymphocytes to form ILFs.

58 monstrate that that similar to PP formation, ILF formation requires lymphotoxin (LT)- and LT beta rec

59 the ESCRT-independent intralumenal fragment (ILF) pathway proposes that the fragment generated by hom

60 e 8-month-long immersive learning framework (ILF), was designed based on the volatility, uncertainty,

61 Furthermore, ILF DCs express CXCL13, and depletion of DCs resulted in

62 IgA sequencing analysis indicated that human ILFs are sites where intestinal adaptive immune response

63 ions of interest were placed on the SLF, IFO-ILF, and PLIC, and tensor metrics were calculated.

64 (P = .504), while mean FA values for the IFO-ILF (P = .009) and PLIC (P < .0001) were higher than tho

65 ncrease in mean axial diffusivity in the IFO-ILF in the control group but not in the dyslexia group.

66 t B lymphocytes in the formation of immature ILFs (loosely organized clusters of B lymphocytes), LT-s

67 are required for the progression of immature ILFs to mature ILFs (organized lymphoid aggregates with

68 B220(+) cells (which we have termed immature ILFs) to well-organized lymphoid nodules (which we have

69 sential role for alpha(4)beta(7)/MAdCAM-1 in ILF development corresponding to the influx of beta(7)-e

70 ing to intestinal lymphoid structures and in ILF development.

71 Concordant with a block in ILF development at a stage corresponding to the influx o

72 These results reveal DC participation in ILF transformation and maintenance and suggest that in p

73 In addition, expression of TRANCE in ILF was concentrated just beneath the follicle-associate

74 the chemokine CXCL13, CP transformation into ILF was arrested.

75 superior frontal volume and lower FA in left ILF.

76 had lower fractional anisotropy in the left ILF (P = .02) than patients without visual hallucination

77 easures of word reading, while only the left ILF correlated with reading comprehension scores.

78 for lower white matter integrity in the left ILF, particularly for patients with a history of visual

79 ng the mean diffusion indices along the left ILF, patients had significantly reduced fractional aniso

80 SM-ILF and M-ILF showed distinct patterns of distribution along the l

81 (PP), mucosal isolated lymphoid follicles (M-ILF), and submucosal ILF (SM-ILF).

82 composition and transcriptional profile of M-ILF and SM-ILF FB differs with SM-ILF FB appearing more

83 l isolated lymphoid follicles (SM-ILFs and M-ILFs, respectively) as well as in GALT-free intestinal l

84 driven positive-feedback loop driving mature ILF formation, mature ILFs express elevated levels of B

85 We demonstrate that mature ILF formation occurs in response to lumenal stimuli, inc

86 ck loop driving mature ILF formation, mature ILFs express elevated levels of B lymphocyte chemoattrac

87 ymphoid nodules (which we have termed mature ILFs).

88 r the progression of immature ILFs to mature ILFs (organized lymphoid aggregates with a follicle-asso

89 s, and the second site functions to modulate ILF binding.

90 Using murine ILF formation as a model, we have examined the roles of

91 CP but not ILF were present in the small intestine from NF-kappaB-i

92 inguished from the LT-dependent formation of ILF and Peyer's patches by not requiring the presence of

93 ated with strengthening (renormalization) of ILF MK (r = -0.90, p < 0.05 corrected), suggesting that

94 uctures fitting the previous descriptions of ILFs, ranging from clusters of B220(+) cells (which we h

95 ls) are indispensable for the development of ILFs.

96 otential role for CCR6 in the development of ILFs.

97 d depletion of DCs resulted in regression of ILFs and disorganization of CPs.

98 s related to the scarcity and small sizes of ILFs and their follicle-associated epithelium (FAE) impe

99 o lymphoid tissues containing lymphocytes or ILFs.

100 Our findings position ILFs as key inductive hubs for regional immunity in the

101 kills: the FA values for both left and right ILF were correlated with measures of word reading, while

102 nd precentral (T = 6.47) gyri, and one right ILF end point, the occipital lobe (T = 5.36).

103 nstead implicating only one tract, the right ILF, in the ASD phenotype.

104 SM-ILF and M-ILF showed distinct patterns of distribution a

105 and transcriptional profile of M-ILF and SM-ILF FB differs with SM-ILF FB appearing more focused at

106 id follicles (M-ILF), and submucosal ILF (SM-ILF).

107 ofile of M-ILF and SM-ILF FB differs with SM-ILF FB appearing more focused at providing T cell suppor

108 and mucosal isolated lymphoid follicles (SM-ILFs and M-ILFs, respectively) as well as in GALT-free i

109 d lymphoid follicles (M-ILF), and submucosal ILF (SM-ILF).

110 ubiquitination system, we demonstrated that ILF cargoes are not degraded through intralumenal fragme

111 row reconstitution studies demonstrated that ILF development is dependent on CCR6-sufficient B lympho

112 These observations indicate that ILFs contain Ag-naive lymphocytes, and suggest that even

113 These findings suggest that ILFs are organized intestinal lymphoid structures whose

114 The ILF DC population was distinguished from that of the lam

115 The ILF framework can help students develop their personal a

116 obtain a spatial gene expression map of the ILF and its associated FAE in the mouse small intestine.

117 onsistent with classical descriptions of the ILF in man and with monkey visual anatomy; (ii) the trac

118 Preoperatively, left-lateralised FA of the ILF was associated with higher prose recall (p<0.01).

119 , frontal brain volumes and integrity of the ILF were identified as the structural correlates of func

120 e in FA was found in MS patients in both the ILFs and IFOFs (p<0.001) and in the left MCP and right S

121 ng the LTi-like cells and lymphocytes, while ILF stromal cells and vessels within ILFs express VCAM-1

122 and mesenchymal cell states associated with ILFs.

123 its ligand CCL20 are highly expressed within ILFs and that B lymphocytes are the largest CCR6-express

124 es, and suggest that events occurring within ILFs shape subsequent immune responses mediated by these

125 he largest CCR6-expressing population within ILFs.

126 , while ILF stromal cells and vessels within ILFs express VCAM-1 and MAdCAM-1, respectively.