ライフサイエンスコーパス: IMP

1 IMP (Integrative Multi-species Prediction), originally r

2 IMP 2.0 integrates updated prior knowledge and data coll

3 IMP administration resulted in remarkable preservation o

4 IMP dehydrogenase (IMPDH) catalyzes the pivotal step in

5 IMP dehydrogenase (IMPDH) is an essential enzyme that ca

6 IMP identifies homologs with conserved functional roles

7 IMP incorporates robust read preprocessing, iterative co

8 IMP integrates prior knowledge and data collections from

9 IMP-1710 stereoselectively labels the catalytic cysteine

10 IMP-3 abundance correlates with tumor aggressiveness and

11 IMPs appear to resume their physiological functions in m

12 IMPs, also known as insulin-like growth factor 2 (IGF2)

13 IMPs, composed of US Food and Drug Administration-approv

14 lood of newborns, indicating that HLA-A*0201/IMP(58-66) Abs are produced in HLA-A*0201(-) mothers and

15 HLA-A*0201/IMP(58-66) Abs were also detected in the cord blood of n

16 d women on delivery, high-titered HLA-A*0201/IMP(58-66) complex-specific IgG Abs were detected in 11

17 e Abs had the same specificity as HLA-A*0201/IMP(58-66)-specific cytotoxic T cells and bound neither

18 tiple targets were detected (4 VIM/OXA-48, 1 IMP-1/NDM, and 1 NDM/KPC).

19 like growth factor 2 mRNA-binding protein-1 (IMP-1) is an oncofetal protein that binds directly to an

20 a-lactamases (including NDM-1, GIM-1, SPM-1, IMP-1, -2, -7, -8, -18, and -27, and VIM-1, -2, and -7),

21 Here, a comprehensive top down study of 152 IMPs and 277 soluble proteins from human H1299 cells inc

22 ts show that, compared with IMP-1 and IMP-2, IMP-3 is enriched in the nucleus, where it binds the tra

23 Xpert Carba-R assay detected 155 targets (26 IMP-1, 30 VIM, 27 NDM, 33 KPC, 39 OXA-48) within a time

24 solates (harboring NDM [n = 7], VIM [n = 3], IMP [n = 2], or KPC [n = 3]) and nine different commerci

25 veral dietary 5'-NMPs, such as 5'-GMP and 5'-IMP, was carried out at high concentrations of guanine a

26 olypeptide sequences corresponding to actual IMPs, the minimum free energy structure with the wild-ty

27 However, the actual benefits of adding IMP to such a procedure remain undocumented.

28 Additionally, IMP 2.0 implements a new flexible platform for experts t

29 Additionally, IMP identifies homologs with conserved functional roles

30 VNRX-5133 activity against IMP-1 and tested B2/B3 MBLs was lower/not observed.

31 T1R1 and T1R3 KO mice when MSG + amiloride + IMP was tested suggests that a T1R1 or T1R3 homodimer or

32 t some were able to detect MSG + amiloride + IMP, but only at the higher MSG concentrations.

33 n cells unable to convert IMP to XMP or AMP (IMP dehydrogenase, guaB; adenylosuccinate synthetase, pu

34 EPS (24 h) increased AMP, IMP, AMPK Thr(172) phosphorylation, PGC1alpha content, a

35 Isn1, initially classified as an IMP-specific 5'-nucleotidase, and Sdt1, initially classi

36 products in living cells by simply fusing an IMP target with truncated apolipoprotein A-I, which serv

37 picomplexan parasites, including Pf, have an IMP-specific-nucleotidase 1 (ISN1).

38 e of the method to study the structure of an IMP, detergent solubilization from the membrane is usual

39 Immune melanization proteases (IMP-1 and IMP-2) and Serpin-1 mediate hemolymph prophenoloxidase c

40 r results show that, compared with IMP-1 and IMP-2, IMP-3 is enriched in the nucleus, where it binds

41 ing drugs as inhibitors of NDM-1, VIM-1, and IMP-7.

42 ke (n = 40), NDM (n = 29), KPC (n = 13), and IMP (n = 9).

43 (5) or NDM-1 (1); one isolate had VIM-2 and IMP-18, and 7 carried no metallo-beta-lactamase (MBL) ge

44 pa) mutants results in Ins accumulation, and IMP-1 expression is reduced in proportion to the increas

45 teractions for the monophosphates of GMP and IMP in several inert complexes.

46 ates positive for OXA-48, KPC, NDM, VIM, and IMP carbapenemases.

47 compositions of OMPs, globular proteins and IMPs separately using a training set.

48 lation of TMPs affects diffusion of TMPs and IMPs of both the inner and outer leaflets by changing th

49 spectrin modifies the diffusion of TMPs and IMPs of the inner leaflet from normal to confined-hop di

50 nce that restricts the diffusion of TMPs and IMPs of the inner leaflet within the membrane skeleton c

51 ould modify transverse diffusion of TMPs and IMPs of the inner leaflet, depending on the strength of

52 o key enzymes in purine salvage pathways are IMP dehydrogenase (GuaB) and GMP synthase (GuaA), encode

53 ween the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein

54 crom(-2) measured was four times the average IMP density (5686 microm(-2) reported in the freeze-frac

55 BTZs bind the di-zinc centers of B1 (IMP-1; BcII) and B3 (L1) MBLs via the free thiol, but or

56 Barley IMP-1 is expressed in all tissues assayed, and expressio

57 osyltransferase (DRTase, encoded by bb0426), IMP dehydrogenase (GuaB) and GMP synthase (GuaA) catalys

58 (KPC) (33.5%), 70 bla (NDM) (21.0%), 8 bla (IMP) (2.4%), and 2 bla (VIM) (0.6%) genes, with positive

59 NDM), bla (VIM), bla (OXA-48-like), and bla (IMP) The goals of this study were to evaluate the perfor

60 bla (NDM), bla (VIM), bla (OXA-48), and bla (IMP)) directly from rectal swabs or purified colonies wi

61 Real-time PCR for bla(KPC), bla(SME), bla(IMP), bla(NDM-1), bla(VIM), and bla(OXA-48) was performe

62 stemin protein degradation in tumor cells by IMP dehydrogenase inhibition or by other small molecules

63 lates (73) carried VIM-2, but others carried IMP-1 or IMP-13 (5) or NDM-1 (1); one isolate had VIM-2

64 ethod to generate Ag-specific "naive" CD8(+) IMP T cells, as well as demonstrate that they are not ho

65 ed by tissue melanization protease (CLIPB8), IMP-1, and Serpin-2.

66 both DNA and RNA in cells unable to convert IMP to XMP or AMP (IMP dehydrogenase, guaB; adenylosucci

67 ition, an X-ray crystal structure of CpIMPDH.IMP.8k is also presented.

68 by ADAL1-catalyzed deamination producing (d)IMP that can enter the nucleotide salvage pathway.

69 Inosine 5'-monophosphate dehydrogenase (IMP dehydrogenase or IMPDH) is a promising target for th

70 ure structure-guided optimization delivering IMP-105 (43), a compound with modest activity against Le

71 , mice lacking T1R1 or T1R3 could not detect IMP alone, yet some were able to detect MSG + amiloride

72 mPTPN release Pi by hydrolyzing GDP/GMP/dGMP/IMP/dIMP, and that AtPTPN positively regulated AsA produ

73 to other self-MHC class I alleles displaying IMP(58-66), but bound to MHC class I complexes of an HLA

74 nophosphates have distinct interactions in E.IMP.NADP(+) and E.GMP.NADP(+) complexes.

75 -ray crystal structure of a representative E.IMP.inhibitor complex is also presented.

76 find that the targeting specificity of each IMP is determined by few amino acids in their variable l

77 This suggests that each IMP contains four prestin molecules, based on the genera

78 nto how their physiological functions enable IMPs to play a potentially key role in cancer stem cell

79 itor of the de novo purine synthetic enzyme, IMP dehydrogenase, leads to the rapid disappearance of n

80 ), which is a potent inhibitor of eukaryotic IMP dehydrogenases (IMPDHs).

81 ba-R assay to include SPM, GES, and expanded IMP variants, increasing the global utility of the test.

82 iaceae and non-Enterobacteriaceae expressing IMP, VIM, KPC, NDM, and/or OXA carbapenemases, by using

83 30-fold higher with TF2-pretargeted Al(18)F-IMP 449 than with the peptide alone.

84 The Al(18)F-IMP 449 was stable for 4 h in serum in vitro, and in ani

85 ability and targeting ability of the Al(18)F-IMP 449 were examined in nude mice bearing LS174T human

86 arly in the bones, than the chelated Al(18)F-IMP 449, which cleared rapidly from the body by urinary

87 Finally, IMP is encapsulated within a user-friendly implementatio

88 e sensitivity of the Xpert Carba-R assay for IMP was 44.4% (95% CI, 18.9% to 73.3%), while that of th

89 K562 cells as a model to explore a role for IMP-3 in cell survival.

90 ression by dendritic cells is sufficient for IMP CD4(+) T cell functional development and prevention

91 yme that irreversibly deaminates AMP to form IMP.

92 laminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (PurH, EC 2.1.2.3/3.5.4.10).

93 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), a single enzyme in de novo pu

94 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase-mediated glucose transporter type 4 (

95 IMPDH derepresses the synthesis of AMP from IMP.

96 tions appear required to differentiate GES-, IMP-, and SPM-producing isolates.

97 member of a novel IMP family, the glutamate IMPs.

98 In the test group, IMP was performed before flap closure, using a round bur

99 2, 96 and 98) determined for the herbicides, IMP, IMZ and IMT, respectively, were greatly superior wh

100 HLA*IMP:02 achieves an average 4-digit imputation accuracy o

101 HLA*IMP:02 is based on a graphical representation of haploty

102 HLA*IMP:02 supports imputation of HLA-DPB1 and HLA-DRB3-5, i

103 In African Americans, HLA*IMP:02 performed marginally better than HIBAG pre-built

104 The imputation framework, HLA*IMP, provides a powerful tool for dissecting the archite

105 We present an HLA type imputation model, HLA*IMP:02, designed to operate on a multi-population refere

106 bute Bagging (HIBAG) method outperformed HLA*IMP:02.

107 ng had consistently higher accuracy than HLA*IMP:02.

108 sical leukocyte antigen (HLA) loci using HLA*IMP:02 with a reference panel from the HapMap Project an

109 y (PA), or individual, impoverished housing (IMP).

110 e cellular nucleotide analogs (hypoxanthine, IMP, and GMP) that we compare with the phosphate-bound e

111 r mRNA isoform of the proto-oncogene IGF2BP1/IMP-1 led to far more oncogenic transformation than did

112 r simultaneous preconcentration of imazapyr (IMP), imazapic (IMZ) and imazethapyr (IMT) with determin

113 Imipenemase (IMP), Klebsiella pneumoniae carbapenemase (KPC), and Ver

114 The eCIM failed to identify all imipenemase (IMP)-producing (n = 22) and Sao Paulo metallo-beta-lacta

115 that they can execute material implication (IMP), which is a fundamental Boolean logic operation on

116 EEV capsid protein (C) by the host importin (IMP) alpha/beta1 nuclear transport proteins.

117 pproach to identify members of the importin (IMP) family of nuclear transporters as interactors of Ei

118 An improvement in IMP detection among isolates was observed (100% detectio

119 sh, complementary to the 44-fold increase in IMP concentration.

120 ed in CE or PA compared to Tg mice reared in IMP housing.

121 elieved by single amino acid replacements in IMP dehydrogenase.

122 roapoptotic protein CYFIP2 is upregulated in IMP-1 knockdown SW480 cells, a novel finding.

123 e five most common carbapenemases, including IMP variants.

124 The knockout phenotypes of individual IMP proteins suggest that each family member regulates a

125 It inhibits IMP dehydrogenase, a rate-limiting enzyme in de novo syn

126 Interestingly, IMP cells fail to differentiate into other mesodermally-

127 P regeneration by converting excess AMP into IMP, thereby driving forward the myokinase reaction (2AD

128 We present KIR *IMP, a method for imputation of KIR copy number.

129 We show that KIR *IMP is highly accurate and thus allows the study of KIRs

130 s for NDM-1 and two related beta-lactamases, IMP-1 and VIM-2, was identified.

131 he isolates with genes for GES, OXA-48-like, IMP, VIM, KPC, and NDM, respectively, were susceptible t

132 Three mammalian IMP paralogs (IMP1-3) have been identified that are expr

133 eta-lactamases (i.e., NDM-1 (New Delhi MBL), IMP-1 (Imipenemase), SPM-1 (Sao Paulo MBL), and VIM-2 (V

134 microM or 36-84 microM for subclass B1 MBLs (IMP-1 and BcII, respectively), and 10-12 microM for the

135 tibility of Escherichia coli-producing MBLs (IMP-1, Sfh-1, BcII, and GOB-18) and, significantly, an e

136 The Ras effector and E3 ligase family member IMP (impedes mitogenic signal propagation) acts as a ste

137 Myoinositol monophosphatase (IMP) is a major enzyme required for the synthesis of myo

138 synthesis pathways-inosine-5'-monophosphate (IMP) dehydrogenase and cytosine triphosphate (CTP) synth

139 to l-glutamate and inosine 5'-monophosphate (IMP) mixtures in a heterologous expression assay in HEK

140 When inosine 5'-monophosphate (IMP), a ribonucleotide that potentiates the l-glutamate

141 ith its substrate, inosine 5'-monophosphate (IMP), and product, xanthosine 5'-monophosphate (XMP).

142 dephosphorylation of inosine monophosphate (IMP) and is allosterically activated by ATP.

143 Inosine monophosphate (IMP) dehydrogenase 2 (IMPDH2) is a rate-limiting enzyme

144 s steps 2, 3 and 5 of inosine monophosphate (IMP) synthesis.

145 monophosphate (AMP), inosine monophosphate (IMP), inosine (Ino) and hypoxanthine (Hx), in fish tissu

146 MSG/IMP+ conditions significantly reduced subsequent intake

147 glutamate and inosine 5'-monophosphate (MSG/IMP) provided either alone or in a high-energy, high-car

148 glutamate and inosine 5'-monophosphate (MSG/IMP+) or without added monosodium glutamate and inosine

149 glutamate and inosine 5'-monophosphate (MSG/IMP-) were consumed on 4 nonconsecutive days, and change

150 The addition of MSG/IMP to a low-energy preload had a biphasic effect on app

151 ion also reduced intake independently of MSG/IMP.

152 carbohydrate and protein conditions than MSG/IMP- condition.

153 The addition of the MSG/IMP+ also increased the soup pleasantness and caused an

154 Energy compensation was greater in the MSG/IMP+ carbohydrate and protein conditions than MSG/IMP- c

155 reduced subsequent intake more than the MSG/IMP- condition did irrespective of energy.

156 ate for TBI, immunomodulatory nanoparticles (IMPs), which ablate a specific subset of hematogenous mo

157 ield the large lipophilic surfaces of native IMPs.

158 that Rce1 is the founding member of a novel IMP family, the glutamate IMPs.

159 In conclusion, a nuclear IMP-3-HNRNPM complex is important for the efficient synt

160 In the absence of IMP-3, the levels of CCND1, D3 and G1 proteins fall dram

161 Addition of IMP to an OFD procedure used to treat intrabony defects

162 The capacity of IMP to inhibit signal propagation through Raf to MEK is,

163 trial was to investigate the contribution of IMP to the outcomes of open-flap debridement (OFD) treat

164 IMPDH catalyzes the conversion of IMP to XMP via a covalent enzyme intermediate, E-XMP*; M

165 donors leads to preferential development of IMP CD4(+) T cells and partially prevents pathogenesis.

166 The functional development of IMP CD4(+) T cells requires hematopoietic but not thymic

167 inase regulate the functional development of IMP CD4(+) T cells, which suppresses the development of

168 ant IGF-II partially reversed the effects of IMP-3 knockdown on IR-induced apoptosis.

169 xpression of IMP proteins, and especially of IMP-3, to an unfavorable prognosis in numerous types of

170 tiple studies have linked high expression of IMP proteins, and especially of IMP-3, to an unfavorable

171 The specific importance of IMP-3 for cancer transformation remains poorly understoo

172 parameters that are important indicators of IMP stability.

173 Knockdown of IMP-3 with siRNA increased susceptibility of cells to IR

174 The nuclear localization of IMP-3 depends on its protein partner HNRNPM and is indis

175 Furthermore, we show that loss of IMP-1 induces Caspase-3- and PARP-mediated apoptosis, an

176 We further show that loss of IMP-1 inhibits Cdc34, Lin-28B, and K-Ras, suppresses SW-

177 We also show that overexpression of IMP-1 increases c-Myc and K-Ras expression and LIM2405 c

178 IMPDH catalyzes the oxidation of IMP to XMP with the concomitant reduction of NAD(+), whi

179 receptor for l-glutamate in the presence of IMP.

180 nzymatic machinery for de novo production of IMP, the first purine nucleotide formed during GTP and A

181 Cytoplasmic retention of IMP-3 and HNRNPM in human cancer cells leads to signific

182 However, the role of IMP-3 in apoptosis is unknown.

183 This was added to a solution of IMP 449 (NOTA-p-Bn-CS-d-Ala-d-Lys(HSG)-d-Tyr-d-Lys(HSG)-

184 The Bateman domain (CBS subdomain) of IMP dehydrogenase (IMPDH), a rate-limiting enzyme of the

185 de, which occurs in the de novo synthesis of IMP, and the conversion of adenylosuccinate to AMP, whic

186 concentrations due, in part, to the taste of IMP.

187 r the identification and characterization of IMPs.

188 rvations, which show restricted diffusion of IMPs of the outer leaflet, with our simulations, we conj

189 hich restricts the longitudinal diffusion of IMPs of the outer leaflet.

190 ur current understanding of the functions of IMPs during normal development and focuses on a series o

191 e to measure the stability and solubility of IMPs by diluting them from their initial solubilization

192 neral strategy for in vivo solubilization of IMPs in structurally relevant conformations without the

193 technique, called SIMPLEx (solubilization of IMPs with high levels of expression), allows the direct

194 owever, functional and structural studies of IMPs are hindered by their hydrophobic nature and the fa

195 o groups: control (OFD alone) or test (OFD + IMP).

196 evident in mandibular sites, in which OFD + IMP doubled the radiographic bone gain obtained by OFD a

197 or obtaining novel structural information on IMPs.

198 3 and G1) in vivo and in vitro, and yet only IMP-3 regulates the expression of these cyclins in a sig

199 ) carried VIM-2, but others carried IMP-1 or IMP-13 (5) or NDM-1 (1); one isolate had VIM-2 and IMP-1

200 No OXA-58-type, NDM-type, VIM-type, or IMP-type producers were detected.

201 lly to IMPbeta1 and IMPalpha2, but not other IMPs, and use a mutated IMPbeta1 derivative to show that

202 alytic site are distinct from those of other IMPs.

203 OTI IMP CD8(+) T cells generated via this method exhibited e

204 ses were the largest and had sparsely packed IMPs.

205 ignating them as invalid metabolic panaceas (IMPs).

206 unt for the size of intramembrane particles (IMPs) expressed in the OHC membrane.

207 most densely packed intramembrane particles (IMPs), whereas the PF-CwC synapses were the largest and

208 T cells are unable to suppress pathogenesis, IMP CD4(+) T cells, which include conventional regulator

209 Intramarrow penetration (IMP) is often incorporated in regenerative periodontal s

210 TF10 and/or TF10-pretargeted hapten-peptide (IMP-288) were conducted in nude mice bearing CaPan1 huma

211 Innate memory phenotype (IMP) CD8(+) T cells are nonconventional alphabeta T cell

212 tive development of innate memory phenotype (IMP, CD44(hi)/CD62L(lo)) CD4(+) T cells.

213 ata using the integrative modeling platform (IMP) and the potential of integrating IR with other biop

214 olites of the purine nucleotide cycle (PNC): IMP, adenylosuccinate, and AMP.

215 Integrative multi-species prediction (IMP) is an interactive web server that enables molecular

216 (median 2, range 1-19 cases), predominantly IMP and KPC, with median pairwise distance of 8 (IQR 4-1

217 Here we present IMP, a reproducible and modular pipeline for the integra

218 f the most potent and selective UCHL1 probe (IMP-1710) to date based on a covalent inhibitor scaffold

219 The Influence Maximization Problem (IMP) aims to discover the set of nodes with the greatest

220 alysis confirmed that these isolates produce IMP-4, an MBL carbapenemase not previously published as

221 dent reductive deamination of GMP to produce IMP.

222 al of the investigational medicinal product (IMP), 25 of the 28 participants were started on adalimum

223 ed to as intermediate mesodermal progenitor (IMP) cells, is capable of unlimited expansion, lacks tum

224 egrative structure determination by programs IMP, Chimera, and BILBOMD, as well as in other applicati

225 erting enzyme 1), an intramembrane protease (IMP) of the endoplasmic reticulum.

226 Immune melanization proteases (IMP-1 and IMP-2) and Serpin-1 mediate hemolymph propheno

227 llicle cells lacking the RNA-binding protein IMP go through one extra division owing to a delay in th

228 The RNA-binding protein IMP-3 is an oncofetal protein overexpressed in many huma

229 l (2)efl and the insulin/IGF-binding protein IMP-L2.

230 cifically with the influenza matrix protein (IMP)-derived peptide(58-66) displayed by HLA-A*0201 comp

231 understanding of integral membrane protein (IMP) structure and function is hampered by the difficult

232 tural studies on integral membrane proteins (IMP).

233 th factor II (IGF-II) mRNA-binding proteins (IMPs), is expressed preferentially in triple-negative br

234 Integral membrane proteins (IMPs) are of great biophysical and clinical interest bec

235 Integral membrane proteins (IMPs) play crucial roles in all cells and represent attr

236 information for integral membrane proteins (IMPs), challenging targets for structural determination.

237 the synthesis of integral membrane proteins (IMPs), the hydrophobic amino acids of the polypeptide se

238 incorporation in integral membrane proteins (IMPs), where poor aqueous solubility and ionization of p

239 s that stabilize integral membrane proteins (IMPs).

240 ins (TMPs), and integral monotopic proteins (IMPs) in both the inner and outer lipid layers.

241 inal steps in the biosynthesis of the purine IMP.

242 synthase), Sk2 (sphingosine kinase) and Ras (IMP dehydrogenase).

243 Our earlier studies showed that reducing IMP-3 abundance with siRNAs reduced proliferation of hum

244 ng domains of the two most distantly related IMPs (ZBP1 and IMP2) bind to different consensus sequenc

245 ctured upon association with IMPs; resulting IMP-beta-strand peptide complexes resisted aggregation w

246 to l-glutamate mixed with the ribonucleotide IMP.

247 shes a "stealth" carrier for the solubilized IMP.

248 I (MHCI)-dependent generation of Ag-specific IMP CD8(+) T cells using bone marrow chimeras.

249 ases such as KPC, NMC-A, IMI, SME, NDM, SPM, IMP, VIM, and OXA-23, 40, 48, 58, 72, 181, and 232 were

250 As such, IMP-3 is proving to be a highly significant biomarker in

251 The suppressor analysis suggests IMP as the key intermediate in the synthesis of the clas

252 Among its many mRNA targets, IMP-3 binds to and promotes translation of insulin-like

253 d downregulates several of its mRNA targets: IMP-1, Cdc34, and K-Ras.

254 ination complex but is more constrained than IMP in that complex, leading to hydride transfer.

255 and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets.

256 We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth

257 We also found that IMP-1 binds to the coding region and 3'UTR of K-Ras mRNA

258 Given that IMP is not thought to affect mGluRs, behavioral detectio

259 These findings indicate that IMP-1, interrelated with c-Myc, acts upstream of K-Ras t

260 Together, these results indicate that IMP-3 acts in part through the IGF-II pathway to promote

261 h belle and Dicer-1 mutants, indicating that IMP functions independently of both cis-inhibition and t

262 Gene reporter assays revealed that IMP-3 acts through the 5' UTR of IGFII mRNA during apopt

263 228 patients with colon cancers reveals that IMP-1 is significantly upregulated in differentiated col

264 Here we show that IMP dehydrogenase-2 (IMPDH2), the rate-limiting enzyme f

265 Results suggest that IMP TM segment partitioning shares important features wi

266 Our findings suggest that IMPs are a clinically translatable acute intervention fo

267 The IMP-based data integration strategy enhances data usage,

268 ld temperature, nutrient limitation, and the IMP dehydrogenase inhibitor mycophenolic acid (MPA).

269 s; the NDM-1 isolate was an outlier, and the IMP isolates and 6/7 MBL-negative isolates clustered sep

270 pes showed positive correlations between the IMP-cluster area and the AMPAR number, indicating a comm

271 with less positive correlations between the IMP-cluster area and the NMDAR number.

272 orporation of our neurosteroid ligand in the IMP, mouse voltage-dependent anion channel-1 (mVDAC1), a

273 RNA-binding proteins of the IMP family (insulin-like growth factor 2 (IGF2) mRNA-bin

274 tarted on adalimumab after withdrawal of the IMP for active JIA-U (median time to flare 188 days [ran

275 Therefore, our implementation of the IMP was framed as an information theoretic problem using

276 ipathic proteic 'shield' that sequesters the IMP from water and promotes its solubilization.

277 By solving the IMP over different numbers of source nodes, an influence

278 the need for detergents or mutations to the IMP itself, as an alternative to extraction and in vitro

279 t maximizes influence is the solution to the IMP.

280 t the longitudinal diffusion of TMPs and the IMPs of the inner leaflet but not of the IMPs of the out

281 the IMPs of the inner leaflet but not of the IMPs of the outer leaflet.

282 We here show that all three IMPs can directly bind the mRNAs of cyclins D1, D3 and G

283 Thus, IMP regulates Notch signalling by controlling the locali

284 Thus, IMP-3 might serve as a new drug target to increase sensi

285 In contrast to normal adult tissue, IMP-1 is reexpressed and/or overexpressed in human cance

286 ase (GMPR) catalyzes the reduction of GMP to IMP and ammonia with concomitant oxidation of NADPH.

287 rast, MHCI(-/-) bone marrow does not lead to IMP CD8(+) T cells in wild-type recipients.

288 Wild-type bone marrow gives rise to IMP CD8(+) T cells in MHCI(-/-) recipients, resembling t

289 ruit (Actinidia deliciosa) has similarity to IMP and can hydrolyze l-galactose 1-phosphate (l-Gal 1-P

290 Carbapenemase classes tested include VIM, IMP, NDM, SPM, KPC, and GES.

291 nemases and the metallo-beta-lactamases VIM, IMP, and NDM-1, even though NDM-1 was only recently iden

292 rbapenemase families (KPC, OXA-48-like, VIM, IMP, and NDM) directly from bacterial colonies.

293 r presence of beta-lactamase (bla) NDM, VIM, IMP, KPC, and OXA carbapenemase genes (e.g., blaOXA-23,

294 r presence of beta-lactamase (bla) NDM, VIM, IMP, KPC, and OXA carbapenemase genes (e.g., blaOXA-23,

295 amily of serine carbapenemases, and the VIM, IMP, and NDM-1 metallo-beta-lactamases.

296 uces the hyperbolic black hole of NPs, where IMPs populate the high-effort base.

297 s for the monophosphate of GMP compared with IMP in their respective NADP(+) complexes.

298 Our results show that, compared with IMP-1 and IMP-2, IMP-3 is enriched in the nucleus, where

299 of the Vibrio cholerae IMPDH in complex with IMP/NAD(+) and XMP/NAD(+).

300 nd become restructured upon association with IMPs; resulting IMP-beta-strand peptide complexes resist