ライフサイエンスコーパス: IMS

1 IMS anti-Salmonella coated magnetic beads were applied t

2 IMS is a gas-phase electrophoretic technique that enable

3 Thus, the time required for acquiring IMS data does not affect the overall run time of traditi

4 showed the transferability of results across IMS platforms.

5 To directly detect S. typhimurium after IMS, a sandwich immunoassay was implemented into the pro

6 Using random forests as an IMS data analysis technique, it was possible to identify

7 Modification of an IMS-capable quadrupole time-of-flight mass spectrometer

8 2 acyl mutants into the mitochondria with an IMS-targeting tag did not recover their ability to suppr

9 As both, ChEC and IMS work at ambient conditions and are driven by high vo

10 d in brain sampling, analyte extraction, and IMS MS method optimization.

11 cted combinations of the MS, MS(2) , LC, and IMS dimensions can be applied, together with the appropr

12 alarm rates and improve the accuracy of any IMS-based instrument, accurate K(0) values of an ion mob

13 ectrometers utilizing commercially available IMS technologies, including drift tube, traveling wave,

14 des using both intact IMS and fragment-based IMS glycan sequencing experiments in positive ion mode,

15 ralong path length traveling wave (TW)-based IMS separations (i.e., on the order of seconds) using st

16 anti-CD24 antibody (referred to as two-bead IMS).

17 The use of ChEC before IMS detection not only facilitated the peak allocation a

18 wever, glycolipidomics of the human brain by IMS MS represents an area untouched up to now, because o

19 these isomers could not be distinguished by IMS-MS alone.

20 lision cross-section (CCS) value provided by IMS is unaffected by the matrix or chromatographic separ

21 allows isolation of CD44(+)/CD24(-) TICs by IMS involving both magnetic beads coated by anti-CD44 an

22 to each GP was successfully detected by CaR(IMS)-ESI-MS; no binding was detected for a noninteractin

23 separation prior to GBP "release" (i.e., CaR(IMS)-ESI-MS), is employed to rapidly identify GBP-GP bin

24 analyzed in less than 80 s, this first ChEC-IMS system was applied to a more complex sample, the ana

25 Here, a commercial IMS-MS platform has been modified for static native ESI

26 We provide novel computed IMS contour plots for a representative selection of arom

27 Here, we describe IMS (TW)CCSN(2) data obtained from a high-throughput LC-

28 gmentation imaging analysis of acquired DESI-IMS data reveals distinct chemical regions corresponding

29 -ESI-MS) via unmediated sampling by MMS DESI-IMS.

30 Membrane scaffolded DESI-IMS has inherent advantages compared to matrix-assisted

31 y ionization-imaging mass spectrometry (DESI-IMS) using microporous membrane scaffolds (MMS) enables

32 Thus, DESI-IMS and unsupervised segmentation spatially annotates th

33 tions, geometric isomers exhibited different IMS arrival time distributions and distinct OzID product

34 Here, we introduce low-field differential IMS (LODIMS), where the field is too weak for significan

35 (MALDI) and other IMS methods through direct IMS analyses of microbial chemistry in situ.

36 ive coupling of linear IMS to MS and diverse IMS/MS arrangements and modalities impossible at ambient

37 tiplexing (SM), and double multiplexing (DM) IMS modes to optimize the signal-to-noise ratio of the m

38 The Flex-DT-IMS is shown to have a resolution >80 and a detection li

39 exible DT ion mobility spectrometer (Flex-DT-IMS) with corresponding electrodynamic (Simion 8.1) and

40 detection in the low ppb range common for DT-IMS.

41 tic drift tube ion mobility spectrometer (DT-IMS) is described.

42 Drift tube ion mobility spectrometers (DT-IMS) separate ions by the absolute value of their low fi

43 long high-performance drift tubes, the dual IMS reaches high resolving power of R = 90 with detectio

44 a >250% increase in the peak capacity during IMS experiments.

45 tegies for combating these challenges during IMS experiments on a hybrid QhFT-ICR MS.

46 ze nanoparticle-protein conjugates, enabling IMS measurements of their conjugate size distribution fu

47 e challenging with previous enantioselective IMS approaches.

48 article, we expand upon current experimental IMS capabilities by predicting the CCS values using a de

49 nt the time scale disparity between the fast IMS separation and the much slower Orbitrap MS acquisiti

50 TWIMS) with different ion sources and faster IMS separations showed the transferability of results ac

51 e, a method for prefiltering analytes in FAT-IMS by the alpha function is introduced to remove spectr

52 ime of flight ion mobility spectrometer (FAT-IMS) allows high repetition rates and reaches limits of

53 ime of flight ion mobility spectrometer (FAT-IMS).

54 Furthermore, the FAT-IMS allows separation of ions prior to dissociation, emp

55 y used devices in mass spectrometry, the FAT-IMS operates at ambient pressure and temperature.

56 The so-called moving field IMS (MOF-IMS) presented here allows a more effective use

57 Fielded IMS-based detectors that are in use for hazardous and il

58 Five IMS bands were assigned to the heterogeneous ion mobilit

59 data obtained from a high-throughput LC-FLR-IMS-MS workflow in positive ion mode.

60 isomeric glycans in a high-throughput LC-FLR-IMS-MS workflow.

61 In this work, a CCS library for IMS-HRMS, which is online and freely available, was deve

62 t-based (DC) switch developed previously for IMS-MS.

63 an be paired with molecular information from IMS for any tissue, cell-type, or activity state for whi

64 FT-IMS separations are demonstrated for tetraalkylammonium

65 When ions are fragmented in the FT-IMS mode, the product ions maintain the frequency and am

66 GC-IMS was used to detect the volatile compound profile of

67 The architecture GC-IMS(2) is compared with GC-IMS obtaining a 100-fold incr

68 ests that mathematical correlations of HS-GC-IMS 3D fingerprints with the sensory analysis may be app

69 the first time, this study describes a HS-GC-IMS strategy for analyzing non-targeted volatile organic

70 These results confirm the potential of GC-IMS based approaches for olive oil classification.

71 Due to the two-dimensional nature of GC-IMS measurements, great quantities of data are obtained

72 erprinting analysis, in which the overall GC-IMS data was processed and ii) a targeted approach based

73 chromatography-ion mobility spectrometry (GC-IMS) to differentiate lactic acid bacteria (LAB) through

74 The results demonstrated that GC-IMS is a useful technology for bacteria recognition and

75 The GC-IMS system was successfully challenged with the analysis

76 e architecture GC-IMS(2) is compared with GC-IMS obtaining a 100-fold increase of sensitivity in the

77 udinal field ion mobility spectrometry (HALF-IMS), which allows separation of ions based on mobility

78 This HALF-IMS chip contains a microscale drift cell where spatiall

79 We describe how IMS is able to distinguish isomeric N-glycans and glycop

80 separating isomer and isobar ions; however, IMS-MS suffers from decreased peak capacity due to the c

81 ts demonstrated the performance of chip-HPLC/IMS as a miniaturized two-dimensional separation techniq

82 ed in infected kidney tissue by MALDI FT-ICR IMS through accurate mass matching.

83 ole in immunoassays (IAs) and immunosensing (IMS) platforms for the detection of carcinoembryonic ant

84 rometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performin

85 ration (IMS) combined with HRMS instruments (IMS-HRMS) introduces an additional analytical dimension,

86 -glycans and glycopeptides using both intact IMS and fragment-based IMS glycan sequencing experiments

87 lue-a parameter related to the shape of ions-IMS can improve the accuracy of metabolite identificatio

88 results established the feasibility of LAESI-IMS-MS for the analysis and spatial mapping of plant tis

89 lity time-of-flight mass spectrometry (LAESI-IMS-TOF-MS) was used for the analysis of synthetic polym

90 ed demonstrate the advantages of using LAESI-IMS-MS for the rapid analysis of intact root nodules, un

91 ilitate nontarget liquid chromatography (LC)-IMS-HRMS data processing.

92 induced dissociation (OzID) in-line with LC, IMS, and high resolution mass spectrometry.

93 lity spectrometry, and mass spectrometry (LC-IMS-MS) to rapidly characterize both known and unknown P

94 This work demonstrates that LC-IMS-MS-enabled untargeted analysis of complex formulatio

95 ons from seven brands were analyzed using LC-IMS-MS in both negative and positive ion modes.

96 Two established branches are linear IMS based on the absolute mobility K at moderate normali

97 Effective coupling of linear IMS to MS and diverse IMS/MS arrangements and modalities

98 ve of mobility vs electric field over linear IMS based on absolute mobility is much greater orthogona

99 tures and addressing the challenges of lipid IMS.

100 MALDI IMS was used to visualize the distribution of antimicrob

101 ed images were acquired in SPRi and in MALDI IMS for abundant proteins from a single mouse kidney tis

102 patial resolution than most metabolite MALDI IMS experiments (20 mum) while maintaining broad coverag

103 a multi-modal molecular imaging (MRI & MALDI IMS) approach was employed to examine the temporal GSK12

104 ing beneficial effects on phospholipid MALDI IMS.

105 loyed MALDI imaging mass spectrometry (MALDI IMS) and MS/MS molecular networking.

106 re found at the inhibition zones using MALDI IMS and were identified using MS/MS molecular networking

107 Additionally, MALDI-IMS is able to detect three metabolites of doxorubicin,

108 owever, current sample preparation and MALDI-IMS acquisition methods have limitations in preserving m

109 This gentle, histology-compatible MALDI-IMS protocol also diminished thermal effects and mechani

110 ulting in interfered correspondence of MALDI-IMS data with subsequently acquired immunofluorescent st

111 tigated the histology compatibility of MALDI-IMS to image neuronal lipids in rodent brain tissue with

112 mplified by performing high-resolution MALDI-IMS with subsequent fluorescent amyloid staining in a tr

113 on of MALDI imaging mass spectrometry (MALDI-IMS) and MS/MS molecular networking to study chemistry-b

114 /ionization imaging mass spectrometry (MALDI-IMS) enables acquisition of spatial distribution maps fo

115 ed by MALDI-imaging mass spectrometry (MALDI-IMS) to verify their identity.

116 /Ionization-Imaging Mass Spectrometry (MALDI-IMS) with confirmation by steady state fluorescence micr

117 together, these results indicate that MALDI-IMS can readily visualize metabolites made by very small

118 port summarizes the first study to use MALDI-IMS to analyze drug penetration of a liposomal drug carr

119 ew as ~50 cells can be visualized with MALDI-IMS.

120 performance with conventionally manufactured IMS instruments that also operate in the open air.

121 In many IMS experiments, the ion signal can be dominated by a fe

122 get of the highly conserved eukaryotic MIA40 IMS oxidoreductase.

123 Occurring within milliseconds, IMS separation is compatible with modern mass spectromet

124 presented here characterize a mitochondrial IMS-localized protein phosphatase identified in photosyn

125 Even with the basic version of an MOF-IMS presented here, it was possible to increase the reso

126 The so-called moving field IMS (MOF-IMS) presented here allows a more effective use of the a

127 of the electronic properties of a molecule, IMS contour plots present a detailed, global landscape o

128 spatial in situ delineation with imaging MS (IMS), we show that Abeta1-40 aggregates at the core stru

129 We obtained IMS data from a selection of RapiFluor-MS (RFMS) labeled

130 The addition of IMS to conventional LC-MS-based metabolomics and lipidom

131 Our method will extend the application of IMS to cell subsets characterized by multiple markers.

132 l challenges have limited the application of IMS to the analysis of proteomes.

133 Comparison of IMS with fluorescence detection and electrospray ionizat

134 The high-fidelity of IMS-MS techniques provides a means of examining the stab

135 Specifically, incorporation of IMS resulted in an increase of 153 differentially abunda

136 heds new insights into the interpretation of IMS-MS data from biomolecular self-assembly studies-an i

137 are presented to highlight the potential of IMS-HRMS and to demonstrate the additional value of CCS

138 analytical setup revealed the suitability of IMS as a promising and powerful detection concept for ch

139 However, demonstrations of the utility of IMS in high-throughput workflows such as liquid chromato

140 aser desorption ionization (MALDI) and other IMS methods through direct IMS analyses of microbial che

141 This enabled the novel LC-OzID-IMS-MS configuration where ozonolysis of ionized lipids

142 MS) technique and associated to the parallel IMS volatile fingerprinting.

143 In particular, IMS data of glycan fragments obtained in positive ion mo

144 ppress the fragment peaks and obtain a plain IMS spectrum for CA containing only one peak in both the

145 In this study, we have chosen five potential IMS calibrants on the basis of their rating against seve

146 As a stand-alone instrument, the 3D printed IMS is shown to achieve resolving powers of between 24 a

147 mobility spectrometry-mass spectrometry (PSI-IMS-MS) is a powerful approach for rapid breast cancer d

148 10-fold compared to traditional single-pulse IMS, enabling the detection of 38 low-intensity features

149 with six replicates each, both quantitative IMS methods achieved relative standard deviations in the

150 Results from rapid IMS-MS analyses provided a link between mass and collisi

151 uscript demonstrates the potential to reduce IMS acquisition time while simultaneously maximizing spe

152 0.25% proved the utility of high resolution IMS-MS for real samples with large interisomeric dynamic

153 nstrument that combines ultrahigh-resolution IMS with cryogenic IR spectroscopy for glycan analysis.

154 lycan analysis combines ultrahigh-resolution IMS-IMS using structures for lossless ion manipulation (

155 PAH pathology and highlights the vital role IMS can play in modern biomedical research.

156 ded by the fragmentation cell and the second IMS stage for the product ion mobility analysis.

157 AD) combined with immunomagnetic separation (IMS) for detecting Salmonella typhimurium.

158 using bead-based immunomagnetic separation (IMS) that typically enriches cells based on one abundant

159 Ion mobility separation (IMS) combined with HRMS instruments (IMS-HRMS) introduce

160 The utilization of ion mobility separation (IMS) improved the molecular coverage, selectivity, and i

161 UPLC) coupled to an ion-mobility separation (IMS) quadrupole-time-of-flight (QTOF) mass spectrometer.

162 calculation of isotropic magnetic shielding (IMS) contour plots, is shown to provide a feature-rich p

163 tion of the ADC and a subsequent 31.5 m SLIM IMS separation, the various drug-bound antibody species

164 We expect high-resolution SLIM IMS separations will augment the existing toolbox for AD

165 pulations coupled to mass spectrometry (SLIM IMS-MS) for the rapid and simultaneous characterization

166 were possible for these large ions with SLIM IMS as compared to ones performed on a commercially avai

167 uick and cost-effective way to produce small IMS instruments that can compete in performance with con

168 However, especially small IMSs suffer from the consequences of low resolving power

169 ns in the mitochondrial intermembrane space (IMS) and mediated by the estrogen receptor alpha (ERalph

170 isting of an N-terminal intermembrane space (IMS) domain and a C-terminal 16-stranded beta-barrel dom

171 ed to the mitochondrial intermembrane space (IMS) where it interacts with the mitochondrial oxidoredu

172 e 2 (3betaHSD2) via its intermembrane space (IMS)-exposed charged unstructured loop region.

173 urround the hydrophilic intermembrane space (IMS).

174 ion directly within the intermembrane space (IMS).

175 idues reside within the intermembrane space (IMS).

176 ity spectrometry-Orbitrap mass spectrometer (IMS-Orbitrap MS) platform.

177 A tandem ion mobility spectrometer (IMS(2)) built from two differential mobility analyzers (

178 Ion mobility spectrometers (IMS) with field switching ion shutters are an excellent

179 ld applications, ion mobility spectrometers (IMSs) are useful because of their extremely low detectio

180 y in quantitative imaging mass spectrometry (IMS) across multiple sites, analysts, and instruments.

181 onization (MALDI) imaging mass spectrometry (IMS) allows for direct mapping of biomolecules in tissue

182 Imaging mass spectrometry (IMS) allows simultaneous mapping of thousands of biosynt

183 onization (MALDI) imaging mass spectrometry (IMS) combined with time-of-flight secondary ion mass spe

184 onization (MALDI) imaging mass spectrometry (IMS) elucidates molecular distributions in thin tissue s

185 Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment

186 Imaging mass spectrometry (IMS) is a powerful emerging tool for mapping the spatial

187 Imaging mass spectrometry (IMS) is quickly becoming a technique of reference to vis

188 onization (MALDI) imaging mass spectrometry (IMS) of bacterial microcolonies.

189 MALDI imaging mass spectrometry (IMS) of low molecular weight ions is particularly challe

190 onization (MALDI) imaging mass spectrometry (IMS) of muscle and abdominal tissue sections identified

191 logical tissue by imaging mass spectrometry (IMS), the limit of detection and dynamic range are of pa

192 onization (MALDI) imaging mass spectrometry (IMS), we determined alterations of lipid profiles specif

193 ionization (LDI) imaging mass spectrometry (IMS).

194 onization (MALDI) imaging mass spectrometry (IMS).

195 Ion mobility spectrometry-mass spectrometry (IMS-MS) and energy-resolved tandem mass spectrometry (ER

196 Ion mobility spectrometry-mass spectrometry (IMS-MS) combined with gas-phase hydrogen-deuterium excha

197 ion-mobility spectrometry mass spectrometry (IMS-MS) could be performed.

198 echniques such as ion mobility spectrometry (IMS) and differential mobility spectrometry (DMS) can be

199 hniques including ion mobility spectrometry (IMS) and liquid chromatography (LC) can separate isomeri

200 combination with ion mobility spectrometry (IMS) and mass spectrometry (MS) measurements.

201 ion combined with ion mobility spectrometry (IMS) and mass spectrometry (MS) techniques are used to m

202 (ESI) paired with ion mobility spectrometry (IMS) and mass spectrometry (MS) to map the free energy f

203 ATDs) recorded by ion mobility spectrometry (IMS) can often be interpreted in terms of the coexistenc

204 Ion Mobility Spectrometry (IMS) coupled to Gas Chromatography (GC), provides a rapi

205 ipulations (SLIM) ion mobility spectrometry (IMS) device capable of switching both positive and negat

206 column coupled to ion mobility spectrometry (IMS) has been explored to classify Iberian ham, to detec

207 Recently, ion mobility spectrometry (IMS) has been used to support metabolomics and lipidomic

208 Ion mobility spectrometry (IMS) has proven to be useful in separating isomer and is

209 Ion mobility spectrometry (IMS) in conjunction with mass spectrometry (MS) has emer

210 rometry (MS), and ion mobility spectrometry (IMS) in positive ion mode.

211 Ion mobility spectrometry (IMS) is a gas phase separation technique, which relies o

212 Ion mobility spectrometry (IMS) is an excellent tool for differentiating isomeric g

213 (MS) coupled with ion mobility spectrometry (IMS) is emerging as an important biophysical technique o

214 ues obtained from ion mobility spectrometry (IMS) measurements were recently demonstrated to reduce t

215 the capability of ion mobility spectrometry (IMS) methods to resolve such isomers for model histone t

216 y associated with ion mobility spectrometry (IMS) or differential mobility spectrometry (DMS).

217 lls by drift-tube ion mobility spectrometry (IMS) quadrupole time-of-flight mass spectrometry.

218 antages of adding ion mobility spectrometry (IMS) separation to existing LC-MS workflows for PFAS ana

219 (chip-HPLC) with ion mobility spectrometry (IMS) via fully integrated electrospray emitters is intro

220 /l-peptides using ion mobility spectrometry (IMS) was impeded by small collision cross section differ

221 nt combination of ion mobility spectrometry (IMS) with cryogenic IR spectroscopy has demonstrated pro

222 he integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap

223 Ion mobility spectrometry (IMS) with mass spectrometry has grown into a powerful ap

224 While combining ion mobility spectrometry (IMS) with tandem mass spectrometry is a powerful means f

225 pectrometry (MS), ion mobility spectrometry (IMS), and molecular dynamics (MD) simulations for probin

226 tography (LC) and ion-mobility spectrometry (IMS), in which separation takes place pre-ionization in

227 Ion mobility spectrometry (IMS)-based instruments have historically been accurate t

228 conds or less for ion mobility spectrometry (IMS)-based separations on the order of 100 milliseconds.

229 values when using ion mobility spectrometry (IMS).

230 raphy (ChEC) with ion mobility spectrometry (IMS).

231 as mobility selection, activation, storage, IMS (n), and importantly custom combinations of these fu

232 monoisotopic ion peak ([M]) after SLIM SUPER IMS with resolving powers of ~400-600.

233 try coupled to mass spectrometry (SLIM SUPER IMS-MS).

234 ultralong path with extended routing (SUPER) IMS separations.

235 evelop the Individualized Metabolic Surgery (IMS) score using a nomogram.

236 In mild T2DM (IMS score </=25), both procedures significantly improved

237 In severe T2DM (IMS score >95), when clinical features suggest limited f

238 Additionally, it enables tandem IMS-IMS prefiltration in dry gas and in vapor doped gas.

239 extend the practice of reactive stage tandem IMS to an expanded selection of volatile organic compoun

240 t kinetic and thermodynamic data from tandem-IMS measurements.

241 port the crystal structure of the N-terminal IMS domain of Toc75 from Arabidopsis thaliana, revealing

242 Further, we highlight that IMS glycan sequencing of fragments obtained from RFMS la

243 The IMS housing and electrodes were printed from nonconducti

244 The IMS signals monitoring during a 24-30h period showed the

245 The IMS stage allows the selection of glycan isomers that di

246 The IMS was manufactured using three-dimensional (3D) printi

247 temperatures (~85 degrees C and above), the IMS-MS spectrum indicates that the folded apoprotein dom

248 s found to upregulate the proteasome and the IMS protease OMI.

249 ds, the Danish population registers, and the IMS Real-World Evidence Longitudinal Patient Database pa

250 e accurately analyzed and agreed upon by the IMS community.

251 mbrane system and show that PE can cross the IMS in both directions.

252 aken together, these results demonstrate the IMS-UPRmt activation in SOD1 familial ALS, and suggest t

253 However, the IMS-UPRmt was never studied in a neurodegenerative disea

254 Recently, we identified the IMS protein Mcp2 as a high-copy suppressor for cells tha

255 ce mutant SOD1 is known to accumulate in the IMS of neural tissue and cause mitochondrial dysfunction

256 We found a significant sex difference in the IMS-UPRmt, because the spinal cords of female, but not m

257 ly initiated by mutant SOD1 localized in the IMS.

258 ation, providing functional insight into the IMS contribution to redox-regulated fusion events.

259 Thus, we investigated the IMS-UPRmt in the G93A-SOD1 mouse model of familial ALS,

260 otentials was developed in order to keep the IMS orifice electrically grounded, allowing for a robust

261 owed a more detailed characterization of the IMS as a new detection method for chip-HPLC.

262 consequences on the acquisition time of the IMS experiment and the resulting file size.

263 ts that can lead to misinterpretation of the IMS results to an unaware analyst.

264 lated that a differential involvement of the IMS-UPRmt could be linked to the longer lifespan of fema

265 ential activation of the ERalpha axis of the IMS-UPRmt.

266 ure trapping ion funnel region preceding the IMS cell.

267 Finally, we show that the IMS glycan sequencing approach can highlight shared stru

268 Results from this study show that the IMS separation provides novel information to support tra

269 argeted to the IMS, we demonstrated that the IMS-UPRmt could be specifically initiated by mutant SOD1

270 mport of Tim17 depends on the binding to the IMS protein Mia40, the oxidoreductase activity of Mia40

271 stly unfolded and is transported back to the IMS to integrate with the TIM23 translocase complex and

272 ch G93A-SOD1 was selectively targeted to the IMS, we demonstrated that the IMS-UPRmt could be specifi

273 -mediated disulfide modifications within the IMS domain are key modulators of reversible Mfn oligomer

274 An important difference between this IMS and other instruments is the absence of a counter ga

275 increase the resolving power of a drift time IMS without employing higher drift voltages and bulky po

276 Here, we use MALDI timsTOF IMS to image low molecular weight metabolites at higher

277 In addition, two commonly used approaches to IMS quantification, the mimetic tissue model and dilutio

278 stry of Transplant Recipients were linked to IMS pharmacy fills (January 1, 2001 to October 1, 2012)

279 approximately 30 residues employing trapped IMS with resolving power up to approximately 340, follow

280 Here, we present a dual drift tube IMS with a new dual field switching ion shutter for gati

281 A custom-built drift tube IMS with shifted potentials was developed in order to ke

282 to a custom-built high-resolution drift tube IMS with shifted potentials.

283 on a commercially available (1 m) drift tube IMS-MS platform.

284 Using a commercially available drift tube IMS-MS, we characterized PFAS species and isomeric conte

285 ompare our results to those using drift-tube IMS and highlight the advantages of the substantial incr

286 sight enables the characterization of unique IMS arrival-time distributions of the isomers which can

287 first time, we were able to successfully use IMS in positive ion mode to determine the branching of i

288 These results highlight the need to use IMS devices with high mobility resolving power for bette

289 S platforms (i.e., Synapt G2-Si and two Vion IMS QToF; bias within the threshold of +/-2.0% for 98.8,

290 s found for DAACP pairs using traveling-wave IMS (TWIMS) with different ion sources and faster IMS se

291 of the recent development in traveling-wave IMS called structures for lossless ion manipulation.

292 of differential or field asymmetric waveform IMS (FAIMS) based on the derivative of mobility vs elect

293 tric field E/N and field asymmetric waveform IMS (FAIMS) relying on the evolution of K at high E/N ca

294 s, differential or field asymmetric waveform IMS (FAIMS) to resolve the isomers, and Orbitrap mass sp

295 nctionality, or hydrodynamic volume, whereas IMS adds selectivity by macromolecular shape and archite

296 tly improving the molecular depth with which IMS can probe tissue samples.

297 nt's suitability as a standard for the wider IMS community.

298 of MD structures were in good agreement with IMS data.

299 by these simulations were in agreement with IMS experiments.

300 rogen/deuterium exchange (HDX) combined with IMS-MS/MS techniques is demonstrated to offer advantages

301 orescence emission data were integrated with IMS data through multimodal image processing with advanc