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1 IVM also markedly increased the potency of ATP and that
2 IVM did not have an effect on AEs or SAEs and is not a v
3 IVM did not produce potentiation of L-glutamate-mediated
4 IVM did not reduce all-cause mortality rates compared wi
5 IVM effectiveness depends on coverage with the highest i
6 IVM experiments have revealed unique insights into the d
7 IVM generates highly complex datasets that often exceed
8 IVM is an effective treatment for vitreous seeding after
9 IVM is an FDA-approved antiparasitic drug that was disco
10 IVM of popliteal LNs after intradermal (i.d.) injection
11 IVM of the microcirculation of the mouse ankle could bec
12 IVM resulted in a 4- to 7-fold increased mortality in mo
13 IVM revealed that ROCK blockade strongly reduced the vel
14 (95% confidence interval (CI) 8.5 to 16.0); IVM-1: 15.2% (95% CI 9.4 to 23.8); SAT: 13.6% (95% CI 7.
15 ticipants randomized to 4 treatment arms: 1) IVM annual at 0, 12, and 24 months; 2) IVM semiannual at
16 e randomly assigned to 4 treatment arms: (1) IVM annually at 0, 12, and 24 months; (2) IVM semiannual
18 s: 1) IVM annual at 0, 12, and 24 months; 2) IVM semiannual at 0, 6, 12, 18 and 24 months; 3) IVM+ALB
19 1) IVM annually at 0, 12, and 24 months; (2) IVM semiannually at 0, 6, 12, 18, and 24 months; (3) IVM
20 alidated the use of CANCOL on challenging 2P-IVM videos from murine organs, obtaining a significant i
23 our-dimensional imaging data obtained via 2P-IVM are classically analyzed by performing automated cel
28 all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1 to 6.5); SAT: 1.1% (95% CI 0.6 t
31 (GluClalphabeta), systemically administered IVM, and then assessed amphetamine-induced rotational be
32 71%) after semiannual IVM, 39/64 (61%) after IVM+ALB annual, and 43/53 (81%) after semiannual IVM+ALB
36 revalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI -0.2 to 2.7, p = 0.10).
40 ma treated with intravenous chemotherapy and IVM as salvage for vitreous seeding, and further to dete
44 heteromeric mutant receptor to both Glu and IVM, and improved the receptor subunits' cooperativity.
48 ast treatment) were 35/56 (63%) after annual IVM, 42/59 (71%) after semiannual IVM, 39/64 (61%) after
49 ast treatment) were 35/56 (63%) after annual IVM, 42/59 (71%) after semiannual IVM, 39/64 (61%) after
50 had normal embryogenesis in the IVM annual, IVM semiannual, IVM+ALB annual and IVM+ALB semiannual gr
51 had normal embryogenesis in the IVM annual, IVM semiannual, IVM+ALB annual, and IVM+ALB semiannual g
52 limited by the narrow focus of its approach; IVM strategies aim only to control arthropod vectors.
57 Mosquitoes ingesting a bloodmeal containing IVM have increased mortality, reducing the probability t
58 for mosquitoes taking bloodmeals containing IVM are used to quantify the mosquitocidal effect of IVM
59 Notably, our data also revealed that current IVM protocols may be failing to satisfy the metabolic de
60 ty, and pharmacokinetics of single-dose DEC, IVM, and ALB in Wuchereria bancrofti-infected Papua New
63 lementation with a methyl donor (SAM) during IVM restored histone H3K4me3 and doubled the IVF success
64 n labeling and label-free techniques empower IVM and OCT for a wide range of preclinical and clinical
66 range of 80-125% (GMR for AUC0-infinity for IVM, 87.9; DEC, 92.9; ALB-SOX, 100.0; and AZI, 100.1).
67 e GMR of Cmax, AUC0-t, and AUC0-infinity for IVM, DEC, ALB-SOX, and AZI were within the range of 80-1
71 orate tumor microenvironment (TME) data from IVM or fixed correlative imaging, we demonstrate that di
74 Twelve eyes demonstrated grade 3 or greater IVM-associated retinal or anterior segment toxicity post
75 abies decreased substantially in all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1
76 cabies prevalence was similar in all groups: IVM-2: 11.7% (95% confidence interval (CI) 8.5 to 16.0);
77 of [(3)H]NAmide, and about half of the [(3)H]IVM binding sites are inhibited by NA with high affinity
82 e current state of the field and outline how IVM can generate new discoveries and serve as a "reality
90 ew, we discuss seminal studies incorporating IVM that have advanced our understanding of the biology
91 Our results suggest that with increasing IVM concentrations the association rate with the hydroph
94 early as 4 hr after a single intraperitoneal IVM injection (10 mg/kg), reached maximal levels by 12 h
107 channels serving as targets for ivermectin (IVM), a broad-spectrum anthelmintic drug used to treat h
108 striatum a modified heteromeric ivermectin (IVM)-gated chloride channel from C. elegans (GluClalphab
113 benefits and harms of the use of ivermectin (IVM) in patients with coronavirus disease 2019 (COVID-19
114 y varying opinions on the use of ivermectin (IVM) throughout the world, with minimal research to supp
115 e drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administration programs
117 We probed these motions using ivermectin (IVM), a macrocyclic lactone that stabilizes the open sta
118 ual or semiannual treatment with ivermectin (IVM; 200 ug/kg) plus albendazole (ALB; 800 mg single dos
119 ual or semiannual treatment with ivermectin (IVM; 200ug/kg) plus albendazole (ALB; 800mg single dose)
121 ase in ATP-induced current amplitudes at low IVM concentrations, and the modest increase in the unita
126 complexes (COCs) during in vitro maturation (IVM), as determined using a combination of non-invasive
128 ed MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% f
129 omised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen a
130 ctive of response to intravitreal melphalan (IVM) in patients treated predominantly with primary intr
131 00 mg (N = 12) or DEC 6 mg/kg + ALB 400 mg + IVM 200 mug/kg (N = 12), and monitored for microfilaria,
133 ted with intravital fluorescence microscopy (IVM), where nearly 90% of all ferumoxytol-containing cel
134 s a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of
136 fection in vivo using intravital microscopy (IVM) and significant findings arising through the applic
137 al imaging, including intravital microscopy (IVM) combined with bioluminescence, as a powerful tool t
141 tion and evolution of intravital microscopy (IVM) has vastly increased our ability to directly visual
142 maged this process by intravital microscopy (IVM) in the ear skin of transgenic mice bearing red-fluo
148 neutrophils in vitro Intravital microscopy (IVM) showed increased association of Ab-opsonized Y. pes
151 hese complex tissues, intravital microscopy (IVM) techniques such as multiphoton microscopy have been
153 nsfer experiments and intravital microscopy (IVM) using both S1P1-/- lymphocytes and recipient wild-t
156 nship using an instrumental variables model (IVM), a quasi-randomization technique for drawing causal
157 myosin coated surfaces in in vitro motility (IVM) assays was much slower compared with adult rabbit s
159 ically multiphoton intravital microscopy (MP-IVM), which allows for the investigation of dynamic biol
163 (NQMI) have more ischemic viable myocardium (IVM) than patients with Q-wave myocardial infarction (QM
168 (EC(50,) approximately 250 nM) the action of IVM was rapid and reversible, resulting in increased amp
172 ncer biology, while clinical applications of IVM and OCT are revolutionizing cancer diagnosis and the
173 omic settings, but the aggregate benefits of IVM are limited by the narrow focus of its approach; IVM
174 was limited by 1) the high concentration of IVM necessary to elicit a consistent silencing phenotype
177 M is official national policy, the degree of IVM implementation, the level of compliance with WHO gui
178 ncreased until 7 days after a single dose of IVM (hazard rate ratio, 1.34 [95% confidence interval, 1
179 s predictive of the total number and dose of IVM injections in eyes treated with intravenous chemothe
180 s predictive of the total number and dose of IVM injections required for treatment in this cohort.
182 ults showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24
184 We have also shown the inhibitory effects of IVM and NA on adult worm motility using Worminator.
185 olled trials (RCTs) assessing the effects of IVM on adult patients with COVID-19 were searched until
188 e review important progress in the fields of IVM and OCT for cancer imaging in living subjects, highl
190 transmission model to estimate the impact of IVM in combination with mass treatment strategies with a
192 Further work to evaluate possibility of IVM as a new insecticide formulation in LLINs and IRS wi
193 CE2) receptors to determine the potential of IVM as a repurposed drug for SARS-CoV-2 prevention and t
196 n endemic area in Ghana after many rounds of IVM, raising concerns of suboptimal response or even the
197 tients, most of them with multiple rounds of IVM, were recruited in areas with IVM suboptimal respons
201 nes, and concordance in the understanding of IVM, and it assesses the operational impact of IVM.
203 considered risky to continue relying only on IVM to combat this phenomenon, we assessed the effect of
204 Additionally, two IVM intermediates and one IVM hybrid retained the insecticidal activity of the par
205 a Markov model based on the presence of one IVM binding site, which described some effects of IVM on
206 n sub-Saharan Africa, successful operational IVM experience comes from relatively few countries.
208 ed following single-dose therapy with DEC or IVM to assess whether these reactions have the same unde
209 adverse events were similar following DEC or IVM, but peaked earlier in subjects who received DEC, co
214 mpared with the standard of care or placebo, IVM did not reduce all-cause mortality, LOS, or viral cl
216 00 mg); arm 2, single-dose ALB (400 mg) plus IVM (600 ug/kg); arm 3, ALB (400 mg) for 3 consecutive d
220 ted from immunohistochemistry or preclinical IVM, and thereby have lower wall shear stress, which inf
222 en SARS-CoV-2 receptor binding domain (RBD), IVM, and their combination using aminopropylsilane (APS)
226 ter annual IVM, 42/59 (71%) after semiannual IVM, 39/64 (61%) after annual IVM+ALB, and 43/53 (81%) a
227 ter annual IVM, 42/59 (71%) after semiannual IVM, 39/64 (61%) after IVM+ALB annual, and 43/53 (81%) a
228 yogenesis in the IVM annual, IVM semiannual, IVM+ALB annual and IVM+ALB semiannual groups respectivel
229 yogenesis in the IVM annual, IVM semiannual, IVM+ALB annual, and IVM+ALB semiannual groups, respectiv
234 treatment of IVM plus ALB was no better than IVM alone for sterilizing, killing adult worms, or achie
235 eatment with IVM plus ALB was no better than IVM alone for sterilizing, killing of adult worms or ach
239 either type of neuron, despite the fact that IVM modulated P2X(4) channels heterologously expressed i
242 electrophysiological exploration showed that IVM (at a moderate concentration of 0.1 nM) functioned a
244 sensitivity to the lactone, suggesting that IVM interacts most favorably with the open conformation
248 scabies prevalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI -0.2 to 2.7, p =
249 female worms had normal embryogenesis in the IVM annual, IVM semiannual, IVM+ALB annual and IVM+ALB s
250 female worms had normal embryogenesis in the IVM annual, IVM semiannual, IVM+ALB annual, and IVM+ALB
256 selected pharmacophores were appended to the IVM macrolide, while retaining one or both sugar moietie
263 ble Kisumu Anopheles gambiae were exposed to IVM on impregnated netting materials and sprayed plaster
271 ent changes in desensitization observed upon IVM application, the significant increase in ATP-induced
273 ons of dendritic cells in vivo and in vitro, IVM impaired T-cell activation, proliferation, and cytok
275 ll of which appears to support a model where IVM binding between subunits stabilizes an open state, a
277 le provides an update on the extent to which IVM is official national policy, the degree of IVM imple
279 rounds of IVM, were recruited in areas with IVM suboptimal response and treated with 100 mg/day doxy
281 t kinetic changes to RBD, when combined with IVM, were found only at a concentration a thousand times