ライフサイエンスコーパス: IgG4

1 with known concentrations for human IgE and IgG4 .

2 y recombinant human Phl p 5-specific IgG1 or IgG4.

3 tric solution structures were determined for IgG4.

4 s tetrameric human hemoglobin (Hb) and human IgG4.

5 compared to those with anti-neurofascin-155 IgG4.

6 per high-power field that were positive for IgG4.

7 mulate somatic mutation of allergen-specific IgG4.

8 a significant increase in allergen-specific IgG4.

9 flammatory and blocking antibody function of IgG4.

10 , AIT is often associated with production of IgG4.

11 ligands without steric clashes, unlike human IgG4.

12 ctors including Sm- and Schistosoma-specific IgG4.

13 nic effects of patient-derived anti-Nfasc155 IgG4.

14 nces in Fc receptor binding between IgG1 and IgG4.

15 combined with rapidly increasing intranasal IgG4/7 antibodies and lack of nasal type I interferon an

16 all, our data suggest that preexisting nasal IgG4/7 antibodies neutralize EHV-1, prevent viral entry,

17 Protected horses had EHV-1-specific IgG4/7 antibodies prior to challenge infection, and intr

18 ficantly higher levels of alpha-gal-specific IgG4 Ab.

19 the anti-inflammatory activity attributed to IgG4 Abs.

20 jective signs (objS) at any dose level, sIgE/IgG4 against Bet v 1 and Gly m 4.

21 LIT were assayed using ImmunoCAP for IgE and IgG4 against whole peanut, Ara h 1, Ara h 2, Ara h 3, Ar

22 Through separation of IgG4 aggregates, by size, we have shown a linear correla

23 ed to have a higher level of peanut-specific IgG4 and a higher peanut-specific IgG4:IgE ratio.

24 IgG4 and Ascaris spp.

25 , Mal d 1 and Pru p 1 bound IgE from all and IgG4 and IgA from the majority of sera.

26 The mRNA levels of IgG4 and IgE, genes specific for Th2 cells, eosinophils,

27 memory B cells, except for those expressing IgG4 and IgE, were reduced.

28 Phleum pratense-specific IgG4 and IgE-blocking factor increased from baseline in

29 inity IgG1 and IgG3, and 1 had high-affinity IgG4 and later developed low-titer FVIII inhibitors.

30 ines to skew the immune response from IgE to IgG4 and regulation of dendritic cell, mast cell, basoph

31 t oral immunotherapy (POIT) were depleted of IgG4 and retested in inhibition assays.

32 h bathing in lakewater, Schistosoma-specific IgG4 and Sm infection.

33 Interestingly, a strong increase in IgG4 and some increase in IgG2 were observed throughout

34 APT), skin testing, serum levels of specific IgG4 and specific IgE and safety were also evaluated.

35 asymmetric IgG1 and asymmetric and symmetric IgG4 and were attributable to the four hinge disulfides.

36 detection of food allergen-specific IgE and IgG4 , and compared it with ImmunoCAP and ImmunoCAP ISAC

37 gG1-4 by ELISA, anti-HLA-total IgG, IgG3 and IgG4, and donor-specific antibody by Luminex assay.

38 ytometry of T cells, and measurement of IgE, IgG4, and facilitated antigen binding.

39 Serum TMA-specific antibody (IgG, IgG4, and IgE) levels were estimated longitudinally (yea

40 -specific IgG, and casein-specific IgE, IgG, IgG4, and IgM levels, as well as immunoglobulin free lig

41 fore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct

42 peanut, Ara h1-h3 IgE, higher peanut IgG and IgG4, and increased pregnancy peanut consumption.

43 t some of the biological properties of human IgG4, and review the recent crystal structures of IgG4-F

44 hypogaea 2-specific IgE, and peanut-specific IgG4, and we analyzed the utility of the different bioma

45 The levels of IgG anti-DSG1 and IgG4 anti-LJM17 and anti-LJM11 antibodies correlated pos

46 mic areas had significantly higher values of IgG4 anti-LJM17 antibodies than nonendemic controls (P <

47 respectively, but no increase with IgG2 and IgG4 anti-RhD Abs.

48 tion by flow of IgM and IgG (mostly IgG1 and IgG4) anti-CD4+ cell Abs in 50% of the patients, with ha

49 Serum levels of total IgG4, anti-Toxocara spp.

50 In humans, IgG4 antibodies against Nfasc155 are implicated in the p

51 Although the role of IgG4 antibodies and OPA in protection is still unclear,

52 L. longipalpis-elicited DSG1-cross-reactive IgG4 antibodies may lead to FS in genetically predispose

53 Human BR1 cells selectively upregulate IgG4 antibodies on differentiation to plasma cells.

54 Passive transfer experiments revealed that IgG4 antibodies target Nfasc155 on Schwann cell surface,

55 py results in the production of blocking IgG/IgG4 antibodies that can inhibit IgE-dependent activatio

56 ver, children with transient CMA had IgE and IgG4 antibodies that more often recognized the same epit

57 IgG4 antibodies were infrequent (<5%) and contributed po

58 nd measurements of allergen-specific IgE and IgG4 antibodies were performed before and after treatmen

59 Four patients displayed predominantly IgG4 antibodies, and one patient presented IgG3 antibodi

60 mune parameters including augmented specific IgG4 antibodies, Th1 skewing and enhanced IL-10.

61 s of rMal d 1-specific IgG1, IgG2, IgG3, and IgG4 antibodies.

62 ecently, a human monoclonal Phl p 7-specific IgG4 antibody (mAb102.1F10) was isolated from a patient

63 aimed to investigate differences in IgE and IgG4 antibody binding to CM epitopes between patients wi

64 imen elicited higher anti-Env IgG1 and lower IgG4 antibody levels in serum, showing for the first tim

65 properties compared with the IgG1, IgG3, and IgG4 antibody subclasses.

66 IgG1 persisting, IgG3 rapidly declining, and IgG4 appearing late.

67 nded to explore the use of allergen-specific IgG4 as a biomarker for compliance.

68 simultaneous detection of allergen-specific IgG4 , as a potential parameter for tolerance developmen

69 ase that demonstrated an association between IgG4 associated AIH and the presence of peripheral blood

70 Immunoglobulin G4 (IgG4) associated autoimmune hepatitis (AIH) has been rec

71 to establish the differential diagnosis with IgG4-associated cholangitis, primary biliary cholangitis

72 uencing accurately distinguish patients with IgG4-associated cholangitis/autoimmune pancreatitis (n =

73 Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expre

74 it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) num

75 of intact, full-length human immunoglobulin (IgG4) at 1.8 angstrom resolution.

76 idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies against phospholipase A2 receptor (P

77 cle-specific tyrosine kinase (MuSK)-specific IgG4 autoantibodies in autoimmune myasthenia gravis (MG)

78 blistering skin disease caused by pathogenic IgG4 autoantibodies to desmoglein 1 (DSG1).

79 In all patients in this cohort, IgG4 autoantibodies were detected in the CSF.

80 nin G1 domains of CASPR2 and always included IgG4 autoantibodies.

81 g plays a substantial role in triggering the IgG4 autoantibody development in FS and provide new insi

82 In this investigation, we dissected the IgG4 autoantibody repertoires used by FS patients in res

83 fogo selvagem [FS]) in which the pathogenic IgG4 autoantibody response to the self-antigen desmoglei

84 be the initial antigenic stimulants for the IgG4 autoimmune responses in FS.

85 c gating strategy to reliably identify blood IgG4(+) B cells to study their cellular and molecular ch

86 The increased frequency of Der p 1-specific IgG4(+) B cells, plasmablasts, and IL-10(+) and dual-pos

87 We demonstrate that dominant IgG4(+) B-cell receptor (BCR) clones determined by next-

88 entified as the most promising candidates by IgG4-based immunoassays with sensitivities of 53% for rO

89 IgG4(+) BCR clones and IgG4/IgG RNA ratio markedly impro

90 r intensity and broader diversity of IgE and IgG4 binding have been found in children with persistent

91 time of tolerance development, both IgE and IgG4 binding intensity decreased significantly, particul

92 Interestingly, differences between IgE and IgG4 binding intensity to CM peptides decreased when the

93 ere able to distinguish the diversity of IgE/IgG4 binding to epitopes in the varying CMA phenotypes.

94 IgE binding to one peptide on Ara h 5 and IgG4 binding to one Ara h 9 peptide were greater in PS t

95 IgE and IgG4 binding to sequential epitopes derived from five ma

96 nd patients' samples were tested for IgE and IgG4 binding using immunofluorescence.

97 ogurt/cheese and whether a patient's IgE and IgG4-binding pattern to milk protein epitopes could dist

98 ne protease-like proteins (Spls) as dominant IgG4-binding S aureus proteins.

99 has a half-life as long as that of IgG2 and IgG4, binds the FcgammaR receptor, and activates complem

100 veloped IMN with intense staining for PLA2R, IgG4, C3, C5b-9, factor B, and properdin and very weak s

101 elationship between epitope-specific IgE and IgG4 can further improve our understanding of the immune

102 Immune complexes with subclasses IgG1 and IgG4 can in vitro be generated by plate absorption, and

103 e other memory B-cell frequencies except for IgG4(+) cells were decreased.

104 ange in allergen-specific immunoglobulin G4 (IgG4), change in asthma control or asthma quality-of-lif

105 ed to those without class II DSA, those with IgG4 class II DSA MFI sum >2000 exhibited an odds ratio

106 The venom-specific IgG4 concentrations increased during VIT (P < .001) alth

107 IgE and IgG4 concentrations were determined for the major allerg

108 Detectable allergen-specific IgG4 could be determined only for low concentrations, bu

109 reduced by depletion of IgG1 and less so by IgG4 depletion.

110 mined by Filariasis Test Strip) and specific IgG4 (determined by Wb123 test), and had a history of an

111 glycoforms of IgG 2/3, and 19 glycoforms of IgG4) directly in unfractionated samples of human plasma

112 Our data suggest that IgG4 DSA may serve as a useful biomarker to identify, am

113 A prominent IgG4 DSA profile was strongly correlated with greater HL

114 vation of the serum IgG4 level, abundance of IgG4 enhanced plasma cell infiltration in the portal reg

115 cy was much higher for models using IgE plus IgG4 epitopes by LPA (84.8%), twice the performance of t

116 rrectly classified with models using IgE and IgG4 epitopes.

117 Increased IgG4-EW, IgA-EW, and IgA2-EW during eOIT are associated

118 Relative increases in IgG4-EW, IgA-EW, and IgA2-EW were observed in responders

119 cytometric analysis of peripheral blood for IgG4-expressing B cells and TH subsets.

120 ers and chemokine receptors was performed on IgG4-expressing B cells, and IgG4 transcripts were analy

121 on of somatic mutations such that monovalent IgG4 Fab-arm-exchanged autoantibodies reach a high-affin

122 IgG4 FAE is suggested to be an important biological mech

123 and review the recent crystal structures of IgG4-Fc.

124 binant LJM17 produced IgG1 antibodies (human IgG4 homolog) that strongly cross-reacted with recombina

125 IgG4 ICs down regulated CD163 and CD206 on M2a cells, an

126 Treatment with IgG4 ICs resulted in expression of FcgammaRII and down m

127 IgG4 iDSA was associated with later allograft injury wit

128 en by IgG3 iDSA, whereas sABMR was driven by IgG4 iDSA.

129 Specific and total IgG1, IgG4, IgA, and IgE from plasma as well as culture supern

130 zed that component-resolved analysis of IgE, IgG4, IgA, IgA1, and IgA2 may identify potential biomark

131 mples were collected, and HDM-specific, IgE, IgG4, IgA1 and IgA2 levels were determined.

132 eptide backbones, derived from IgG1, IgG2/3, IgG4, IgA1, IgA2, and the joining chain from dimeric IgA

133 IgG4, IgE, and cell-specific signatures are regulated in

134 cific IgE, level of peanut-specific IgE, and IgG4/IgE ratio also had 100% sensitivity but slightly lo

135 cutaneous reactions (P = .022) and enhanced IgG4/IgE ratios (P = .012).

136 Levels of IgG4 to egg proteins and IgG4/IgE ratios were higher in those randomized to egg (

137 Increases in peanut-specific IgG4 levels and IgG4/IgE ratios were observed in peanut EPIT-treated par

138 e dust mite-specific IgG/IgE ratios (but not IgG4/IgE ratios) were significantly lower in children wi

139 y to rMal d 1 nor enhanced rMal d 1-specific IgG4/IgE ratios.

140 of OIT and associated with increased peanut-IgG4/IgE ratios.

141 resents an additional hallmark of T(H)2-like IgG4/IgE responses.

142 Ratios of IgG4/IgE to 4 out of the 7 peptides were higher in PS th

143 IgG4/IgE, IgA/IgE, and IgA2/IgE ratios for EW and IgA/Ig

144 = 0.038), IgE-OVM (P = 0.032), and a higher IgG4/IgE-OVM ratio (P = 0.013) were associated with clin

145 t-specific IgG4 and a higher peanut-specific IgG4:IgE ratio.

146 ck test and a lower ratio of peanut-specific IgG4:IgE were associated with peanut allergy.

147 chain reaction (qPCR) protocol analyzing the IgG4/IgG RNA ratio in blood also achieves excellent diag

148 IgG4(+) BCR clones and IgG4/IgG RNA ratio markedly improve delineation, early d

149 In this study, mAbs A-C of IgG1 and IgG4 (immunoglobulin G, IgG) isotypes with oxidized tryp

150 IgG4 in 17.5% and 8.0% of parents and offspring, respect

151 is suggests an interplay of macrophages with IgG4 in immune tolerance, likely relevant in allergen im

152 This study fosters our understanding of IgG4 in particular and our appreciation of antibody flex

153 and casein-specific IgG and casein-specific IgG4 in patients with CM-FPIES versus those tolerating C

154 ic IgE appears to determine the induction of IgG4 in the updosing phase.

155 the role of the specific subclasses IgG1 or IgG4 in this phenotypic and functional change is not kno

156 centers of their Fab regions than those for IgG4, in agreement with their hinge lengths of 15 and 12

157 ific IgG1 promote OPA, and that CSP-specific IgG4 interferes with OPA, which we subsequently confirme

158 ely devoid of effector function, whereas the IgG4 isotype can undergo in vivo Fab arm exchange leadin

159 cular helper cell subset that contributes to IgG4 isotype switching have both been defined by multipl

160 tion status and only marginally involves the IgG4 isotype.

161 IgG2 and IgG4 isotypes have significantly lower binding affinity

162 The updosing phase induced a specific IgG4 level increase from a median of 0 ISU before treatm

163 ore was compatible with definite AIH and his IgG4 level was elevated.

164 diagnosis is based on elevation of the serum IgG4 level, abundance of IgG4 enhanced plasma cell infil

165 Increases in peanut-specific IgG4 levels and IgG4/IgE ratios were observed in peanut

166 Tissue IgE and IgG4 levels are elevated in AERD, and higher IgE levels

167 Serum IgG4 levels correlated with the eosinophil and neutrophi

168 in allergen component-specific serum IgE and IgG4 levels during the updosing phase of subcutaneous im

169 , this qPCR test performed better than serum IgG4 levels in sensitivity (94% vs. 86%) and specificity

170 Specific IgG4 levels increased to 1.6-fold (70 mug), 3.1-fold (17

171 Specific IgG4 levels increased, while both CD203c+ and CD63+ baso

172 The elevated IgG4 levels may be a biomarker for efficacy of VIT in cM

173 ped desensitization had a larger increase in IgG4 levels to alpha-lactalbumin (P = 0.034), beta-lacto

174 IgE and IgG4 levels to selected peptides were quantified using I

175 Specific serum IgG and IgG4 levels were dose dependently increased.

176 Tissue IgE and IgG4 levels were elevated in AERD compared with in contr

177 ls of memory B cells were reduced, and serum IgG4 levels were elevated.

178 Egg-specific IgG4 levels were substantially higher in the egg group a

179 sensitization to EW and induced egg-specific IgG4 levels.

180 ta collected for a pharmaceutically relevant IgG4 mAb being characterized to determine the effects of

181 tween these two responses, as all identified IgG4 mAbs cross-react to both Dsg1 and LJM11 Ags.

182 IgE and IgG4 measurements supported these findings and demonstra

183 Increasing somatic mutation of IgG4 members of a clone was seen in immunotherapy, where

184 analyses revealed increased numbers of blood IgG4(+) memory B cells in patients with IgG4-RD.

185 e serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

186 lts suggest that the overlap between IgE and IgG4 might be important in natural tolerance acquisition

187 acy of IgE was 86% (AUC = 0.89) while of IgE+IgG4 model was 81% (AUC = 0.94).

188 l stability is similar to the wild-type (WT) IgG4 molecules (except for some small difference in the

189 IgG4 molecules have been incubated under a range of cond

190 difference between the knob-into-hole and WT IgG4 molecules in E. coli.

191 cterize biopharmaceutical samples, including IgG4 monoclonal antibodies (mAbs) and recombinant human

192 Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Ralpha

193 mab (CAT-354) is an IL-13-neutralising human IgG4 monoclonal antibody that has shown clinical benefit

194 Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor

195 y included skin test, serum specific IgE and IgG4, nasal allergen provocation test (NAPT), and advers

196 a1/beta-actin, and FOXP3/beta-actin than did IgG4-negative MZL (p < 0.05).

197 MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4(+) plasma cells are unk

198 tal imaging is accurate for the diagnosis of IgG4, NSOI, and TED.

199 ody subclasses, immunoglobulin G (IgG) 1 and IgG4, on five different x-ray and neutron instruments to

200 nd increased or reduced levels of IgE, IgG1, IgG4 or IgA specific to most Bet v 1-related allergens.

201 ying precisely defined ICs of the subclasses IgG4 or IgG1 constructed by two independent methods.

202 ICs, plates were coated with myeloma IgG1 or IgG4, or with grass pollen allergen Phl p 5 followed by

203 of an IgE inhibitor, such as peanut-specific IgG4 (P-sIgG4), in PS patients.

204 antagonist) combined with pembrolizumab (an IgG4 PD-1 antagonist) in patients with previously treate

205 We assessed nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, for safe

206 These results indicate that anti-Nfasc155 IgG4 perturb conduction in absence of demyelination, val

207 x protein P3 (FoxP3)+ regulatory T cells and IgG4 plasma cells; and abundant arachidonate 15-lipoxyge

208 ZL) and without (IgG4-negative MZL) numerous IgG4(+) plasma cells are unknown.

209 Fibrosis and accumulation of IgG4(+) plasma cells in tissue are hallmarks of the dise

210 at the balance between milk-specific IgE and IgG4 plays a major role.

211 ver biopsy revealed interface hepatitis with IgG4 positive plasma cell infiltration in the portal reg

212 Panelists agreed that a maximum number of 30 IgG4-positive plasma cells per high-power field in the o

213 s expressed by the podocyte, and both induce IgG4-predominant humoral immune responses that produce c

214 and B-cell responses, regulation of IgE and IgG4 production, and inhibition of responses from eosino

215 Nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibit

216 IgG-subclasses (sIgG1, sIgG4 including SIgE/IgG4 ratio), (iii) Serum inhibitory activity for IgE (Ig

217 Ocular IgG4-RD and IgG4-associated MZL exhibited significantly

218 in tissue are hallmarks of the disease, and IgG4-RD is associated with increased IgG4 serum levels.

219 ineation, early diagnosis, and monitoring of IgG4-RD of the biliary tree and pancreas.

220 of a quantitative disease activity tool (the IgG4-RD Responder Index) and the validation of classific

221 y both the robust clinical responsiveness of IgG4-RD to B cell depletion and by the identification of

222 IgG4-related disease (IgG4-RD) has only existed as a unique disease entity sin

223 IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition affec

224 Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) of the biliary tree and pancreas is difficult t

225 xteen patients with histologically confirmed IgG4-RD, 11 patients with sarcoidosis, and 30 healthy su

226 Furthermore, patients with IgG4-RD, but not patients with sarcoidosis, had increase

227 phocyte signature" observed in patients with IgG4-RD, could support diagnosis and treatment monitorin

228 dysregulated IgG4 response in patients with IgG4-RD.

229 common disease pathogenesis in patients with IgG4-RD.

230 lood IgG4(+) memory B cells in patients with IgG4-RD.

231 sensitive nor specific for the diagnosis of IgG4-RD.

232 bset of ocular MZLs arises in the setting of IgG4-RD.

233 made in understanding the pathophysiology of IgG4-RD.

234 sments for human onchocerciasis are based on IgG4 reactivity against the OV-16 antigen, with sensitiv

235 Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) of the biliary tree and

236 ormed, and a diagnosis of immunoglobulin G4 (IgG4)-related disease was made based on identification o

237 ay drive the generation of autoantibodies in IgG4-related autoimmune diseases.

238 IgG4-related disease (IgG4-RD) has only existed as a uni

239 IgG4-related disease (IgG4-RD) is a systemic fibroinflam

240 The three central pathology features of IgG4-related disease are lymphoplasmacytic infiltration,

241 and effects from prednisone treatment among IgG4-related disease with salivary gland lesions (RD-SG)

242 rgans, is considered part of the spectrum of IgG4-related disease, and often arises in patients with

243 alists to develop alternative treatments for IgG4-related disease.

244 mbalance of immune and inflammatory cells in IgG4-related disease.

245 ormed, but the results were inconclusive for IgG4-related disease.

246 arged and given steroid therapy for presumed IgG4-related disease.

247 In cases of IgG4-related ocular disease, similar pathogens were dete

248 atients), sarcoidosis (4 scans, 3 patients), IgG4-related ophthalmic disease (IgG4-ROD) (5 scans, 3 p

249 (RD-SG), without SG lesions (RD-nonSG), and IgG4-related retroperitoneal fibrosis (RF).

250 nephrotic syndromes and one patient with an IgG4-related retroperitoneal fibrosis.

251 90,437 acceptable conformations for IgG1 and IgG4, respectively, joint x-ray and neutron scattering c

252 s provide new insights into the dysregulated IgG4 response in patients with IgG4-RD.

253 SP-mediated OPA and an enhanced CSP-specific IgG4 response.

254 The kinetics of appearance of these IgG4 responses based on experimentally infected non-huma

255 Further, the IgG4 responses to both OVOC10469 and OVOC3261 (as well a

256 IgG4 responses to recombinant A. fumigatus allergens wer

257 IgG4 responses to these 7 proteins were assessed by luci

258 ligands 18 and 13 and major collagen genes, IgG4-rich immune complexes coating alveolar macrophages,

259 patients), IgG4-related ophthalmic disease (IgG4-ROD) (5 scans, 3 patients), and granulomatosis with

260 y rate of radiologic diagnosis was 80.0% for IgG4-ROD, 77.3% for NSOI, and 73.2% for TED.

261 The data for IgG4 (S228P), an antibody targeting the natriuretic pept

262 Induced IgG4 seems to suppress IgE levels on ISAC, resulting in

263 se, and IgG4-RD is associated with increased IgG4 serum levels.

264 ImmunoCAP ISAC and correlated with IgE- and IgG4 -specific fluorescence on silicon microarrays.

265 IgG and IgG4 specificities and levels could not discriminate bet

266 Docking simulations with our best-fit IgG4 structures showed greater steric clashes with its r

267 odness-of-fit R factors for 28 IgG1 and 2748 IgG4 structures that satisfied the disulphide connectivi

268 95% confidence interval [CI] 4.38-98.69) and IgG4 subclass composition >5% exhibited an OR of 8.99 (9

269 Cross-linking of FcgammaRIIb by the IgG4 subclass redirects pro-allergic M2a macrophages to

270 nly produce GAD65 antibodies of the IgG1 and IgG4 subclasses and are as abundant as B cells reactive

271 e the existence of the human IgG1, IgG2, and IgG4 subclasses and explain the receptor-binding functio

272 Interestingly, both IgE and IgG4 subsets have a 2-fold higher propensity to acquire

273 Phospholipase A2-specific IgG4-switched memory B cells expanded after bee venom ex

274 nezumab is a humanized anti-Abeta monoclonal IgG4 that binds multiple forms of Abeta, with higher aff

275 IgG4, the least represented human IgG subclass in serum,

276 lateral flow rapid diagnostic test to detect IgG4 to both Ov-16 and OVOC3261 was developed and tested

277 Levels of IgG4 to egg proteins and IgG4/IgE ratios were higher in

278 at week 156, higher baseline peanut-specific IgG4 to IgE ratio and lower Ara h 2 IgE and basophil act

279 after OIT regarding serum levels of IgE and IgG4 to milk and five milk allergen components evaluated

280 Ability of peptide-specific IgG4 to surmount their IgE counterpart seems to be impor

281 th alpha-gal syndrome do not have detectable IgG4 to the oligosaccharide.

282 milk proteins with high- or very high-titer IgG4 to the same proteins.

283 IgE and IgG4 to these antigens were quantified using ImmunoCAP((

284 as performed on IgG4-expressing B cells, and IgG4 transcripts were analyzed for somatic hypermutation

285 hieving SU, subjects achieving SU had higher IgG4 values (P = .001) and lower egg skin prick test sco

286 n controls (P < .01 for IgE and P < .001 for IgG4 vs CRSwNP).

287 IgG4 was detected in 29.2% of parents and 10.3% of offsp

288 ique non-IgG2 anti-DNA deposit, and anti-C1q IgG4 was mainly detected in subepithelial membranous dep

289 s: rLinB-13 was the top performing molecule; IgG4 was the most predominant antibody subclass and anti

290 ication of internal calibrations for IgE and IgG4 were assessed.

291 in basophil activation and specific IgE and IgG4 were assessed.

292 Post-SLIT sera depleted of IgG1 or IgG4 were compared for their IgE-blocking activity.

293 Allergen-specific IgE and IgG4 were detected in parallel using two fluorescent dye

294 IgG4 were established by ELISA in 2 cohorts: parents bor

295 Alternatively, immune complexes with IgG1 or IgG4 were formed using protein L.

296 tracellular proteins targeted by human serum IgG4 were identified by means of immunoblotting to scree

297 The levels of HDM specific IgE and IgG4 were increased compared to baseline in all subgroup

298 ions (ADRs) and immunological response (IgE, IgG4) were evaluated post hoc in three subgroups (body w

299 of human anti-natriuretic peptide receptor A IgG4 with the neonatal Fc receptor, Fcgamma receptors, a

300 reactivity in RA was against pepsin-cleaved IgG4, with a 35% prevalence, >/=5.8-fold higher than in