ライフサイエンスコーパス: IkappaB kinase

1 al events lead to the activation of the IKK (IkappaB kinase).

2 manner, and is abolished upon inhibition of IkappaB kinase.

3 ogen synthase kinase 3 and two inhibitors of IkappaB kinase.

4 ine residues within the catalytic domains of IkappaB kinase.

5 heir spatial separation from the cytoplasmic IkappaB kinase.

6 effect of p53 on ubiquitin-related genes or IkappaB kinases.

7 factors RelA and IFN regulatory factor 3 and IkappaB kinases.

8 The molecular mechanism by which IkappaB kinase 1 (IKK1) regulates epidermal differentiat

9 This is triggered by IkappaB kinase 2 (IKK-2) phosphorylation of the p105 PES

10 IkappaB kinase 2 (IKK2) is the upstream kinase that is c

11 IkappaB kinase 2 (IKK2) is well known for its pivotal ro

12 AK1) phosphorylation of NF-kappaB-activating IkappaB kinase 2 (IKK2), leading to increased NF-kappaB

13 ted NF-kappaB essential modulator (NEMO) and IkappaB kinase 2 (IKK2), two essential mediators of the

14 .1292dupG in exon 13 of IKBKB, which encodes IkappaB kinase 2 (IKK2, also known as IKKbeta)--leading

15 ed NF-kappaB by interfering with endothelial IkappaB kinase 2 activity in vitro and in vivo.

16 f NF-kappaB, or with SC 514, an inhibitor of IkappaB kinase 2 decreased GRK5.

17 e both inhibited by the NF-kappaB inhibitors IkappaB kinase 2 inhibitor and NF-kappaB essential modul

18 o express either cyclooxygenase-2 (COX-2) or IkappaB kinase-2 (IKK2), and TP53(+/+) or TP53(f/f) spec

19 TNF-induced NF-kappaB signaling upstream of IkappaB kinase activation absolutely requires the influx

20 rom the nucleus to the cytosol, resulting in IkappaB kinase activation by mechanisms not yet fully un

21 , and 42, leading to attenuation of MAPK and IkappaB kinase activation in B cells during BCR signalin

22 The enhanced JNK and IkappaB kinase activation in DUSP14-deficient T cells wa

23 ng IkappaBalpha and IkappaBbeta cleavage and IkappaB kinase activation, DENV protease activates NF-ka

24 chanism of NF-kappaB induction not involving IkappaB kinase activation.

25 A20(ZF7) cells exhibited prolonged IkappaB kinase activity that drove exaggerated transcrip

26 a phosphorylation without affecting upstream IkappaB kinase activity.

27 IkappaB kinase alpha (IKKalpha) activity is required for

28 We identified the two kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta

29 Despite their homology, IkappaB kinase alpha (IKKalpha) and IKKbeta have diverge

30 s targeting the NF-kappaB regulatory kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, we find tha

31 We investigated the role of IkappaB kinase alpha (IKKalpha) in pancreatic homeostasi

32 Here we report that IkappaB kinase alpha (IKKalpha) is a critical negative r

33 IkappaB kinase alpha (IKKalpha) is part of the cytoplasm

34 as independent of NIK's known function as an IkappaB kinase alpha (IKKalpha) kinase, because mice car

35 We previously reported that IkappaB kinase alpha (IKKalpha), a component of the kina

36 by producing lymphotoxin, which activates an IkappaB kinase alpha (IKKalpha)-BMI1 module in prostate

37 Coexpression of dominant-negative mutants of IkappaB kinase alpha (IKKalpha)/IKK1 or IKKbeta/IKK2 als

38 Breast milk appeared to suppress intestinal IkappaB kinase alpha and beta, resulting in inactivation

39 ced the complete degradation of both BTK and IkappaB kinase alpha in MCL lines and CD40-dependent B c

40 tivity was required for maintaining a stable IkappaB kinase alpha subunit (IKKalpha) level because tr

41 molecule to independently bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

42 ished downstream mediators of NIK signaling, IkappaB kinase alpha/beta (IKKalpha/beta) and NF-kappaB,

43 s associated with reductions in sMLA-induced IkappaB kinase alpha/beta and IFN regulatory factor 3 ac

44 1 significantly increased phosphorylation of IkappaB kinase alpha/beta and IkappaBalpha resulting in

45 d by increased abundance of RelB and phospho-IkappaB kinase alpha/beta, an indirect activator of NF-k

46 (phospho-nuclear factor-kappaB p65, phospho-IkappaB kinase alpha/beta, interleukin 1beta, and tumor

47 glycerophosphoinositol-dependent decrease in IkappaB kinase alpha/beta, p38, JNK, and Erk1/2 kinase p

48 miR-148a is an inhibitor of the IkappaB kinase alpha/NUMB/NOTCH pathway and an inducer o

49 sed differentiated phenotype and mediated by IkappaB kinase alpha/NUMB/NOTCH signaling.

50 such as inhibitor of nuclear factor kappa B (IkappaB) kinase alpha (IKKalpha), IKKbeta, and IKKepsilo

51 t genome-wide siRNA screen demonstrated that IkappaB kinase-alpha (IKK-alpha) is a crucial host facto

52 IkappaB kinase-alpha (IKKalpha) is required for splenic

53 nes encoding IFN regulatory factor 6 (IRF6), IkappaB kinase-alpha (IKKalpha), and stratifin (SFN) exh

54 complex, NF-kappaB-inducing kinase-dependent IkappaB kinase-alpha activation, and p52/RelB nuclear tr

55 through inhibitor of nuclear factor-kappaB (IkappaB) kinase-alpha (IKK-alpha), a protein kinase that

56 gnaling pathways in mice with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the inte

57 uced activation of TAK-1 and ERK1/2, whereas IkappaB kinase and IkappaB were phosphorylated, even in

58 lyubiquitination of RIP1, phosphorylation of IkappaB kinase and IkappaBalpha, and IkappaBalpha degrad

59 hyper-proliferation and hyper-activation of IkappaB kinase and MAPKs (ERK, p38, and JNK) upon the li

60 ism by which the deubiquitinase A20 inhibits IkappaB kinase and NF-kappaB activation.

61 ignaling pathway that involves activation of IkappaB kinase and nuclear factor kappaB (NF-kappaB).

62 nitiated) cells (e.g. through suppression of IkappaB kinase and nuclear factor kappaB as well as othe

63 signal via the adaptor protein connection to IkappaB kinase and stress-activated protein kinases (CIK

64 phosphorylation, suggesting a suppression of IkappaB kinase and thus IkappaB-alpha activation.

65 ty and phosphorylation of p65, IkappaBalpha, IkappaB kinase, and Akt.

66 rming growth factor-beta activated kinase-1, IkappaB kinase, and NF-kappaB pathways.

67 hibitor of NF-kappaB (IkappaB) proteins, and IkappaB kinases are present in a variety of invertebrate

68 an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key kinase in the ca

69 capable of expressing constitutively active IkappaB kinase beta (CAIKKbeta) in airway epithelium wer

70 , IL-1 receptor-associated kinase 4 (IRAK4), IkappaB kinase beta (IKKB), IkappaB kinase iota (IKKI),

71 eta-resistant variants, genetic depletion of IkappaB kinase beta (IKKbeta) (activated during hyperamm

72 nvolves an increased nuclear accumulation of IkappaB kinase beta (IKKbeta) and an increased recruitme

73 anonical and noncanonical NF-kappaB pathways IkappaB kinase beta (IKKbeta) and IKKalpha to activate N

74 kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta) as RelB interacting partne

75 sgenic mice expressing constitutively active IkappaB kinase beta (IKKbeta) in intestinal epithelial c

76 IkappaB kinase beta (IKKbeta) is a crucial kinase that r

77 Here, we report that IkappaB kinase beta (IKKbeta) is activated upon glutamin

78 Overexpression of IkappaB kinase beta (IKKbeta) or p65-RHD causes nuclear

79 pression enhances LPA-induced MEKK3-mediated IkappaB kinase beta (IKKbeta) phosphorylation and NF-kap

80 d that knockdown or blocking the activity of IkappaB kinase beta (IKKbeta) prevented the aggregation

81 IkappaB kinase beta (IKKbeta), a central coordinator of

82 IkappaB kinase beta (IKKbeta), a central coordinator of

83 teracts with and promotes the degradation of IkappaB kinase beta (IKKbeta), a component of the Ikappa

84 ownstream of the T-cell receptor (TCR) or of IkappaB kinase beta (IKKbeta), we demonstrate that NF-ka

85 We also demonstrate that IFN-gamma activates IkappaB kinase beta (IKKbeta)-dependent NF-kappaB to reg

86 hysiological basis of canonical or classical IkappaB kinase beta (IKKbeta)-nuclear factor kappaB (NF-

87 tively active form of the upstream activator IkappaB kinase beta (IKKbeta).

88 on loop that is essential for MEKK3-mediated IkappaB kinase beta (IKKbeta)/NF-kappaB activation.

89 We previously found that the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway regulate

90 ritive and genetic inhibition of the central IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-

91 Manipulating the IkappaB kinase beta activity coupled with in vivo and in

92 ed LPS-dependent activation of NF-kappaB and IkappaB kinase beta activity, protected against LPS acti

93 sgenic mice expressing constitutively active IkappaB kinase beta in airway epithelium (IKTA (IKKbeta

94 ophagy in promoting obesity were reversed by IkappaB kinase beta inhibition in the brain.

95 and in vitro kinase assays demonstrated that IkappaB kinase beta is a key serine/threonine kinase act

96 Using brain-specific IkappaB kinase beta knockout mice, it was found that the

97 Expression of a constitutively active IkappaB kinase beta mutant not only decreased Fgf-10 pro

98 including the activation of proinflammatory IkappaB kinase beta pathway.

99 IkappaB kinase beta plays a critical role in TNFR1 phosp

100 Notably, NF-kappaB signaling through IkappaB kinase beta protected crypt IECs but did not pro

101 r-associated factor 6 (TRAF6) and attenuates IkappaB kinase beta-dependent (IKKbeta-dependent) phosph

102 bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

103 [inhibitor of transcription factor NFkappaB (IkappaB) kinase beta; an upstream kinase responsible for

104 pression by decreasing the activation of the IkappaB-kinase beta-RelA NF-kappaB pathway.

105 s involves hypothalamic immunity mediated by IkappaB kinase-beta (IKK-beta), nuclear factor kappaB (N

106 appaB (NF-kappaB) and its upstream activator IkappaB kinase-beta (IKK-beta, encoded by Ikbkb) in the

107 IkappaB kinase-beta (IKKbeta) mediates activation of the

108 NEMO affects the activity of IkappaB kinase-beta (IKKbeta), which relieves the inhibi

109 d inhibits its phosphorylation on Ser-209 by IkappaB kinase-beta (IKKbeta).

110 reduced phosphorylative activation, reducing IkappaB kinase-beta activation and intrinsic activity, t

111 with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the intestinal epithelium.

112 uclear factor-kappaB-alpha level and reduced IkappaB kinase-beta phosphorylation, suggesting a suppre

113 Previously, we reported that IkappaB kinase-beta(IKKbeta) phosphorylates and stabiliz

114 was inhibited by dominant-negative AP-1 and IkappaB kinase-beta, but stimulated by WT AP-1 and Ikapp

115 B kinase-beta, but stimulated by WT AP-1 and IkappaB kinase-beta, suggesting that PKC-theta stimulate

116 ough the innate immune receptor MDA5 and the IkappaB kinase-beta-NF-kappaB pathway.

117 ing the activation and intrinsic activity of IkappaB kinase-beta.

118 ARD11)-TAK1 (MAP3K7)-inhibitor of NF-kappaB (IkappaB) kinase-beta (IKKbeta) module is a switch mechan

119 of ERK, but not Jun NH2-terminal kinase and IkappaB kinase, blocked the downregulation of Baf60c and

120 el pathway components functioned upstream of IkappaB kinase complex (IKK) activation.

121 Inhibition of the IkappaB kinase complex (IKK) has been implicated in the

122 The IkappaB kinase complex (IKK) is a key regulator of immun

123 pstream of NEMO, a regulatory subunit of the IkappaB kinase complex (IKK).

124 g NF-kappaB signaling via its effects on the IkappaB kinase complex and resulting in reduced IL2 gene

125 of exon 20 and a corresponding reduction in ikappaB kinase complex associated protein (IKAP) levels.

126 Selective autophagic degradation of the IkappaB kinase complex prevents constitutive activation

127 re, digitization occurs well upstream of the IkappaB kinase complex, as protein kinase C translocatio

128 s process occurred through activation of the IkappaB kinase complex, which also led to activation of

129 cytoplasm through the kinase activity of the IkappaB kinase complex, which leads to translocation of

130 omozygous point mutation in IKBKAP, encoding IkappaB kinase complex-associated protein.

131 ppaB inhibitors, a process controlled by the IkappaB kinase complex.

132 actor kappaB (NF-kappaB) is activated by the IkappaB kinase complex.

133 eceptor that mediates the degradation of the IkappaB kinase complex.

134 ecifically suppressing the activation of the IkappaB kinase complex.

135 reduces the survival of pericytes through an IkappaB kinase-dependent pathway, mediates the low peric

136 biquitin protease OTU domain that diminished IkappaB kinase-dependent phosphorylation and activation

137 These results suggest that the control of IkappaB kinase dephosphorylation by gamma(1)34.5 represe

138 n of the noncanonical IkappaB kinase kinases IkappaB kinase e and TBK1, which are upregulated by over

139 tivation of TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) and the subsequent a

140 manner that requires the kinase activity of IkappaB kinase epsilon (IKKepsilon) and the transactivat

141 paB kinases TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) have shown to stimul

142 we show that the phosphorylation of STAT1 by IkappaB kinase epsilon (IKKepsilon) inhibits STAT1 homod

143 gnaling kinases TANK-binding kinase 1 (TBK1)/IkappaB kinase epsilon (IKKepsilon) on the same serine-7

144 to functionally and physically interact with IkappaB kinase epsilon (IKKepsilon), a known IRF3 kinase

145 f a number of cellular factors including the IkappaB kinase epsilon (IKKepsilon).

146 IkappaB kinase epsilon (IKKepsilon; IKKi, encoded by IKB

147 Here we show that the atypical IkappaB kinase epsilon and TANK-binding kinase 1 (IKKeps

148 1, which interacts with and acts upstream of IkappaB kinase epsilon to contribute to LPS-mediated ind

149 erminal "intrinsically disordered" region by IkappaB kinase epsilon.

150 support for a rationale to target IKBKE, an IkappaB kinase family member that activates the AKT and

151 the inhibitor of the nuclear factor kappaB (IkappaB) kinase family.

152 ies have demonstrated that ubiquitination of IkappaB kinase gamma (IKKgamma), a regulatory subunit of

153 B essential modifier (NEMO), also designated IkappaB kinase gamma (IKKgamma), from the nucleus to the

154 paB essential modulator (NEMO; also known as IkappaB kinase gamma subunit [IKKgamma]).

155 binding to the NEMO/inhibitor of NF-kappaB (IkappaB) kinase gamma (IKKgamma) subunit of an IKK compl

156 presses NF-kappaB upstream of the regulatory IkappaB kinase-gamma protein subunit in the NF-kappaB si

157 Here we demonstrate that sumoylation of the IkappaB kinase homolog immune response-deficient 5 plays

158 (PP1), and Akt (SH-5) through inhibition of IkappaB kinase, IkappaBalpha phosphorylation, and inhibi

159 The noncanonical IkappaB kinases IKK-varepsilon and TANK-binding kinase 1

160 , by assessing the kinetics and amplitude of IkappaB kinase (IKK) activation, we report that TNF-alph

161 ium mobilization, as well as PI3K, MAPK, and IkappaB kinase (IKK) activation.

162 d by vorinostat in EOC cells is dependent on IkappaB kinase (IKK) activity and associated with a gene

163 art of a multicomponent complex that induces IkappaB kinase (IKK) activity and NF-kappaB activation.

164 ines with this deletion, exhibited increased IkappaB kinase (IKK) activity and production of proinfla

165 IkappaB kinase (IKK) activity was also reduced, which is

166 potentiated the TNFalpha-induced increase in IkappaB kinase (IKK) activity, as well as the expression

167 lecule that is an upstream regulator of both IkappaB kinase (IKK) and c-Jun N-terminal kinase (JNK),

168 on, and B56gamma silencing induced increased IkappaB kinase (IKK) and IkappaBalpha phosphorylation up

169 IkappaB kinase (IKK) and its downstream target NF-kappaB

170 Activation of IkappaB kinase (IKK) and NF-kappaB by genotoxic stresses

171 attern-independent agonist for activation of IkappaB kinase (IKK) and NF-kappaB in HM via activation

172 ibitor of kappaB (IkappaB)alpha degradation, IkappaB kinase (IKK) and p38 activation, RelA nuclear tr

173 In these cells, S1P, but not TNF, promotes IkappaB kinase (IKK) and p65 phosphorylation, IkappaBalp

174 ALT1-BCL10 (CBM) adapter complex to activate IkappaB kinase (IKK) and the classical NF-kappaB pathway

175 We now present evidence that IkappaB kinase (IKK) beta-mediated RelA Ser-536 phosphor

176 This is achieved through subversion of the IkappaB kinase (IKK) complex (or signalosome), which inv

177 Because CsA has the capability to impair IkappaB kinase (IKK) complex activation, the IKKalpha/be

178 IkappaB kinase (IKK) complex phosphorylation of the TPL-

179 aB kinase beta (IKKbeta), a component of the IkappaB kinase (IKK) complex that regulates nuclear fact

180 DRAIC interacted with subunits of the IkappaB kinase (IKK) complex to inhibit their interactio

181 thesized that the MC159 protein targeted the IkappaB kinase (IKK) complex to inhibit these diverse si

182 MC005 inhibited NF-kappaB proximal to the IkappaB kinase (IKK) complex, and unbiased affinity puri

183 ulator (NEMO), a regulatory component of the IkappaB kinase (IKK) complex, controls NF-kappaB activat

184 mplicated in the activation of the canonical IkappaB kinase (IKK) complex.

185 aB essential modulator (NEMO) subunit of the IkappaB kinase (IKK) complex.

186 cifically inhibit NF-kappaB by targeting the IkappaB kinase (IKK) complex: Compound A and NEMO bindin

187 factor-alpha (TNFalpha), TG2 did not require IkappaB kinase (IKK) for NF-kappaB activation.

188 F) 6, TGF-beta-activated kinase (TAK) 1, and IkappaB kinase (IKK) gamma is largely unknown.

189 NLRX1 interacts with TRAF6 or IkappaB kinase (IKK) in an activation signal-dependent f

190 and is sustained by constitutive activity of IkappaB kinase (IKK) in the cytoplasm.

191 hanges, we observed significant increases in IkappaB kinase (IKK) in the NAc after social defeat, a m

192 Activation of the IkappaB kinase (IKK) is central to NF-kappaB signaling.

193 degradation of NFkappaB-bound IkappaB by the IkappaB kinase (IKK) is required for activation in respo

194 a complex with the modulatory subunit of the IkappaB kinase (IKK) kinase, IKKgamma (or NEMO), resulti

195 f key inflammatory mediators such as JNK and IkappaB kinase (IKK) occurs rapidly upon consumption of

196 The IkappaB kinase (IKK) pathway is an essential mediator of

197 ion of the c-Jun N-terminal kinase (JNK) and IkappaB kinase (IKK) pathway.

198 ctivation through the TNF receptor 1 (TNFR1)/IkappaB kinase (IKK) pathway.

199 t of RIP1 to the receptor complex, impairing IkappaB kinase (IKK) recruitment and NF-kappaB activatio

200 n mice with sepsis and whether inhibition of IkappaB kinase (IKK) reduces the cardiac dysfunction in

201 crotic RIP1-RIP3 kinase complex, whereas the IkappaB Kinase (IKK) subunit NEMO appears to function do

202 tion of IkappaBalpha, and phosphorylation of IkappaB kinase (IKK) subunits IKKalpha and IKKbeta, indi

203 ear transcription factor kappaB (IkappaB) by IkappaB kinase (IKK) triggers the degradation of IkappaB

204 tors of c-Jun N-terminal kinase (JNK) and of IkappaB kinase (IKK) were used to investigate the involv

205 lex program is in operation, which activates IkappaB kinase (IKK), a key regulator of inflammatory cy

206 TRE17 co-precipitates with IkappaB kinase (IKK), and IKK activity is augmented in s

207 of five pleiotropic signaling kinases: Akt, IkappaB kinase (IKK), c-jun N-terminal kinase (JNK), mit

208 phosphatidylinositol 3-kinase (PI 3-kinase), IkappaB kinase (IKK), IkappaB, NF-kappaB, and FGF-2 were

209 Nuclear factor (NF)-kappaB, activated by IkappaB kinase (IKK), is a key regulator of inflammation

210 Chemical inhibition of IkappaB kinase (IKK), mitogen-activated protein extracel

211 , transforming growth factor beta (TGFbeta), IkappaB kinase (IKK), Ras/mitogen-activated protein kina

212 ophagy factor ATG1/ULK1 and the noncanonical IkappaB kinase (IKK), TANK-binding kinase 1 (TBK1), whic

213 nd activation of the pathway is dependent on IkappaB kinase (IKK), which phosphorylates IkappaB, targ

214 Central to NF-kappaB activation is IkappaB kinase (IKK), which phosphorylates IkappaBalpha,

215 ppaB inhibitor, was depleted due to enhanced IkappaB kinase (IKK)-alpha activity.

216 tabilized NIK, and led to phosphorylation of IkappaB kinase (IKK)-alpha.

217 acilitates ubiquitination and degradation of IkappaB kinase (IKK)-beta thus terminating IKK activity.

218 C, [Ca(2+)]i, protein kinase C) and requires IkappaB kinase (IKK)-beta.

219 The importance of IkappaB kinase (IKK)-induced proteolysis of NF-kappaB1 p

220 The role of IkappaB kinase (IKK)-induced proteolysis of NF-kappaB1 p

221 lammatory cytokines TNF and IL-17 stimulated IkappaB kinase (IKK)-NF-kappaB and impaired osteogenic d

222 IKKepsilon, an IkappaB kinase (IKK)-related kinase, is implicated in in

223 NF receptor-associated factor 6 (TRAF6), and IkappaB kinase (IKK)-related kinases, but not for TRIF-r

224 a complex including BCL10, MALT1, and other IkappaB kinase (IKK)-signalosome components.

225 , which coordinates downstream activation of IkappaB kinase (IKK).

226 ligase TRAF6 is a key regulator of canonical IkappaB kinase (IKK)/NF-kappaB signaling in response to

227 Induction of TRAF3IP2 activates IkappaB kinase (IKK)/NF-kappaB, JNK/AP-1, and c/EBPbeta

228 ptic contacts may depend at least in part on IkappaB kinase (IKK)/NF-kappaB-related synapse-to-nucleu

229 ntial role in inflammation by activating the IkappaB kinase (IKK)/nuclear factor kappaB (NF-kappaB) a

230 inhibition induces a nuclear accumulation of IkappaB kinase (IKK)alpha, and inhibition of IKKalpha en

231 However, phosphorylated IkappaB kinase (IKK)alpha/beta expression and NF-kappaB

232 the TCR that activates the protein kinase C-IkappaB kinase (IKK)alpha/beta-NF-kappaB pathway, known

233 activation of IRF5 was dependent on TAK1 and IkappaB kinase (IKK)beta, which thus reveals a physiolog

234 Inhibitor of IkappaB kinases (IKK) are key regulators of NF-kappaB si

235 ay and exerts its function by recruiting the IkappaB kinases (IKK) to the IKK complex.

236 The inhibitor of nuclear factor-kappaB (IkappaB) kinase (IKK) complex is the master regulator of

237 We identified the inhibitor of kappaB (IkappaB) kinase (IKK) complex regulatory subunit NEMO [n

238 c process by activating inhibitor of kappaB (IkappaB) kinase (IKK) complex, which subsequently recrui

239 ly controlled by the inhibitor of NF-kappaB (IkappaB) kinase (IKK) complex.

240 , a component of the inhibitor of NF-kappaB (IkappaB) kinase (IKK) complex.

241 Mice lacking the inhibitor of NF-kappaB (IkappaB) kinase (IKK) kinase TAK1 underwent normal posit

242 Inhibitor of kappaB (IkappaB) kinase (IKK) phosphorylates IkappaB proteins, l

243 in the activation of inhibitor of NF-kappaB (IkappaB) kinase (IKK) through a proteasome-independent m

244 RF3) and inhibitor of nuclear factor-kappaB (IkappaB) kinase (IKK)/nuclear factor-kappaB (NFkappaB) s

245 The IkappaB-Kinase (IKK) complex-consisting of the catalytic

246 Last, U(L)26 blocks TNF-alpha-induced IkappaB-kinase (IKK) phosphorylation, a key step in NF-k

247 ith MHC-I, MyD88-dependent TLR signals drive IkappaB-kinase (IKK)2-mediated phosphorylation of phagos

248 dulator (NEMO; the regulatory subunit of the IkappaB kinase [IKK] complex).

249 lacking the p65 subunit of NF-kappaB or the IkappaB kinases IKKalpha or IKKbeta, and in cells treate

250 macological inhibition of both the canonical IkappaB kinases (IKKalpha/beta) and the IKK-related kina

251 er demonstrated decreased phosphorylation of IkappaB kinase (IKKbeta) and IkappaBalpha in the presenc

252 Inhibition of IkappaB kinase (IKKbeta) and NF-kappaB leads to cell dea

253 in persistent elevation of the noncanonical IkappaB kinases IKKepsilon and TBK1.

254 cilitated the complex formation of CD91 with IkappaB kinases (IKKs) alpha and beta and increased the

255 While aspirin directly inhibits IkappaB kinases (IKKs) to phosphorylate IkappaBalpha for

256 st lethal challenge from wild-type virus via IkappaB kinase in dendritic cells (DCs), which sense vir

257 utive noncanonical NF-kappaB activation, and IkappaB kinase inhibition reduced their proliferation to

258 Consistent with this, the IkappaB kinase inhibitor BAY11-7085 and dominant-negativ

259 S422D)SGK1-transfected MEG-01 cells with the IkappaB kinase inhibitor BMS-345541 (10muM) abolished SG

260 Experiments using an IkappaB kinase inhibitor support the conclusion that thi

261 nin (a PI3K inhibitor), and parthenolide (an IkappaB kinase inhibitor), inhibited pathogen-induced NF

262 Moreover, this synergy was blocked by an IkappaB kinase inhibitor, BAY 11-7082.

263 inase 4 (IRAK4), IkappaB kinase beta (IKKB), IkappaB kinase iota (IKKI), interferon regulatory factor

264 amycin; DAF, decay-accelerating factor; IKK, IkappaB kinase; IRF, interferon regulatory factors; TBK1

265 ed in the identification of the noncanonical IkappaB kinase kinases IkappaB kinase e and TBK1, which

266 ivation in tumor cells through inhibition of IkappaB kinase, leading to inhibition of phosphorylation

267 rough PUMA-MPC interaction, which depends on IkappaB kinase-mediated phosphorylation of PUMA at Ser96

268 Hyperammonemia triggered activation of IkappaB kinase, NF-kappaB nuclear translocation, binding

269 The IkappaB kinase-NF-kappaB signaling pathway is required f

270 romoted constitutive activation of PI3K/Akt, IkappaB kinase/NF-kappaB, mitogen-activated protein kina

271 ignature included "protein kinase cascade," "IkappaB kinase/NFkappaB cascade," and "regulation of pro

272 in cytosolic Ca(2+) levels or the classical IkappaB kinase/NFkappaB inflammatory response elicited b

273 injury by suppressing the activation of the IkappaB kinase-nuclear factor-kappaB pathway.

274 IkappaB kinase/nuclear [corrected] factor kappaB (IKK/NF

275 histone deacetylase activity and blockade of IkappaB kinase/nuclear factor-kappaB signaling during re

276 Gram-negative bacteria, Akt did not enhance IkappaB kinase or NF-kappaB p65 phosphorylation, but rat

277 ts activation of NF-kappaB by inhibiting the IkappaB kinase pathway and by promoting direct inhibitor

278 ies implicate Erb3 binding protein-1 and the IkappaB kinase pathway in the mechanism of action of WS6

279 phoma cells with inhibitors of the NF-kappaB/IkappaB kinase pathway or deletion of c-Rel or RelA resu

280 activated CaMKII in cardiomyocytes leads to IkappaB kinase phosphorylation and concomitant increases

281 the ability of TLR stimuli to induce optimal IkappaB kinase phosphorylation and nuclear translocation

282 NF-alpha activity was mediated by inhibiting IkappaB kinase phosphorylation, which attenuated the LPS

283 Analyses of NF-kappaB and IkappaB kinase proteins from Aiptasia suggest that non-c

284 cids via mammalian target of rapamycin 2 and IkappaB kinase regulate Akt activity and Akt association

285 Here, we found that inducible IkappaB kinase-related (IKK-related) kinase IKBKE expres

286 Genetic studies in mice have identified the IkappaB kinase-related kinase TANK-binding kinase 1 (TBK

287 tion of RalB (RAS-like proto-oncogene B) and IkappaB kinase-related TANK-binding kinase 1 (TBK1) acti

288 demonstrated that kinetic considerations of IkappaB kinase-signaling input and IkappaBepsilon's inte

289 Inhibition or deletion of the upstream IkappaB kinase substantially reduced SINV replication in

290 B (NF-kappaB) essential modulator (NEMO) and IkappaB kinase subunit beta (IKKbeta), an interaction th

291 rectly binds the NF-kappaB-activating kinase IkappaB kinase subunit gamma (NEMO or NF-kappaB essentia

292 Small-molecule inhibitors of non-canonical IkappaB kinases TANK-binding kinase 1 (TBK1) and IkappaB

293 Hippo kinases MST1, MST2, and the oncogenic IkappaB kinase TBK1 as the most enriched RASSF1A-interac

294 tment of TAX1BP1 and A20 to the noncanonical IkappaB kinases TBK1 and IKKi in response to poly(I:C) t

295 K Binding Kinase 1 (TBK1) is a non-canonical IkappaB kinase that contributes to KRAS-driven lung canc

296 Tid1 is an essential mediator that connects IkappaB kinases to the Beclin1-containing autophagy prot

297 a macrophage-specific constitutively active IkappaB Kinase transgenic model (IKFM), we demonstrated

298 y inhibiting the activation of non-canonical IkappaB kinase varepsilon and IkappaBalpha, and conseque

299 its downstream molecules, including JNK and IkappaB kinase, were enhanced in DUSP14-deficient T cell

300 more, the gamma(1)34.5 null mutant activates IkappaB kinase, which facilitates p65/RelA phosphorylati