ライフサイエンスコーパス: IkappaB

1 IkappaB kinase (IKK) complex phosphorylation of the TPL-

2 IkappaB kinase 2 (IKK2) is the upstream kinase that is c

3 IkappaB kinase 2 (IKK2) is well known for its pivotal ro

4 IkappaB kinase alpha (IKKalpha) activity is required for

5 IkappaB kinase beta (IKKbeta) is a crucial kinase that r

6 IkappaB kinase beta (IKKbeta), a central coordinator of

7 IkappaB kinase beta (IKKbeta), a central coordinator of

8 IkappaB kinase-beta (IKKbeta) mediates activation of the

9 IkappaB kinase/nuclear [corrected] factor kappaB (IKK/NF

10 IkappaB-alpha was able to counteract the effect of TCF4

11 IkappaB-zeta is regulated bi-modally at the stages of tr

12 rming growth factor-beta activated kinase-1, IkappaB kinase, and NF-kappaB pathways.

13 ALT1-BCL10 (CBM) adapter complex to activate IkappaB kinase (IKK) and the classical NF-kappaB pathway

14 mmatory chemokines by reducing TNF-activated IkappaB through p53 stabilization.

15 Induction of TRAF3IP2 activates IkappaB kinase (IKK)/NF-kappaB, JNK/AP-1, and c/EBPbeta

16 AK1) phosphorylation of NF-kappaB-activating IkappaB kinase 2 (IKK2), leading to increased NF-kappaB

17 Before activation, IkappaB proteins sequester NF-kappaB dimers in the cytop

18 In the case of NF-kappaB activation, IkappaB phosphorylation leads to its degradation, follow

19 tively active form of the upstream activator IkappaB kinase beta (IKKbeta).

20 capable of expressing constitutively active IkappaB kinase beta (CAIKKbeta) in airway epithelium wer

21 Expression of a constitutively active IkappaB kinase beta mutant not only decreased Fgf-10 pro

22 a macrophage-specific constitutively active IkappaB Kinase transgenic model (IKFM), we demonstrated

23 anced DNA binding affinity without affecting IkappaB degradation or p65 nuclear translocation.

24 Gene expression profiling after IkappaB-zeta knockdown demonstrated a significant downre

25 of five pleiotropic signaling kinases: Akt, IkappaB kinase (IKK), c-jun N-terminal kinase (JNK), mit

26 nhancer in B-cell inhibitor-alpha (PKC-alpha/IkappaB-alpha)-mediated or calcineurin/IkappaB-beta-depe

27 an essential role in AIAD via the PKC-alpha/IkappaB-alpha- and calcineurin/IkappaB-beta-dependent NF

28 by producing lymphotoxin, which activates an IkappaB kinase alpha (IKKalpha)-BMI1 module in prostate

29 support for a rationale to target IKBKE, an IkappaB kinase family member that activates the AKT and

30 nin (a PI3K inhibitor), and parthenolide (an IkappaB kinase inhibitor), inhibited pathogen-induced NF

31 reduces the survival of pericytes through an IkappaB kinase-dependent pathway, mediates the low peric

32 lly, PKCdelta activates NF-kappaB through an IkappaB-independent cytosolic interaction, which subsequ

33 Experiments using an IkappaB kinase inhibitor support the conclusion that thi

34 cids via mammalian target of rapamycin 2 and IkappaB kinase regulate Akt activity and Akt association

35 hat was associated with augmented ERK1/2 and IkappaB-alpha phosphorylation and increased levels of CC

36 duced mononuclear recruitment and ERK1/2 and IkappaB-alpha phosphorylation.

37 utive noncanonical NF-kappaB activation, and IkappaB kinase inhibition reduced their proliferation to

38 bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

39 tion of RalB (RAS-like proto-oncogene B) and IkappaB kinase-related TANK-binding kinase 1 (TBK1) acti

40 ation of proteasome substrates p27, Bax, and IkappaB-alpha, inhibits survival pathways and viability,

41 ced the complete degradation of both BTK and IkappaB kinase alpha in MCL lines and CD40-dependent B c

42 ng IkappaBalpha and IkappaBbeta cleavage and IkappaB kinase activation, DENV protease activates NF-ka

43 hate enabled its incorporation into DHFR and IkappaB-alpha using wild-type ribosomes, and the elabora

44 kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta) as RelB interacting partne

45 f key inflammatory mediators such as JNK and IkappaB kinase (IKK) occurs rapidly upon consumption of

46 The enhanced JNK and IkappaB kinase activation in DUSP14-deficient T cells wa

47 its downstream molecules, including JNK and IkappaB kinase, were enhanced in DUSP14-deficient T cell

48 ontaining other members of the NF-kappaB and IkappaB families.

49 Analyses of NF-kappaB and IkappaB kinase proteins from Aiptasia suggest that non-c

50 of ERK, but not Jun NH2-terminal kinase and IkappaB kinase, blocked the downregulation of Baf60c and

51 TAK-1 and ERK1/2, whereas IkappaB kinase and IkappaB were phosphorylated, even in basal conditions.

52 ium mobilization, as well as PI3K, MAPK, and IkappaB kinase (IKK) activation.

53 ted NF-kappaB essential modulator (NEMO) and IkappaB kinase 2 (IKK2), two essential mediators of the

54 B (NF-kappaB) essential modulator (NEMO) and IkappaB kinase subunit beta (IKKbeta), an interaction th

55 sults presented a novel mechanism of PKA and IkappaB pathway, which may be targeted for treating S. a

56 plex) are present in anucleate platelets and IkappaB is phosphorylated upon activation, suggesting th

57 y and also inhibits TNF-alpha production and IkappaB degradation in a dose-dependent manner.

58 in the interaction between DENV protease and IkappaB-alpha/beta, the enzymatic activity is critical t

59 activation of IRF5 was dependent on TAK1 and IkappaB kinase (IKK)beta, which thus reveals a physiolog

60 paB kinases TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) have shown to stimul

61 NF receptor-associated factor 6 (TRAF6), and IkappaB kinase (IKK)-related kinases, but not for TRIF-r

62 -induced NF-kappaB nuclear translocation and IkappaB degradation.

63 r-associated factor 6 (TRAF6) and attenuates IkappaB kinase beta-dependent (IKKbeta-dependent) phosph

64 d others found that IkappaBzeta, an atypical IkappaB family member and transcriptional coactivator of

65 We demonstrate that IkappaBzeta, an atypical IkappaB family member and transcriptional coactivator re

66 We found that expression of the atypical IkappaB member IkappaB (inhibitor of NF-kappaB) zeta, a

67 aB RelA, cRel, and RelB dimers, the atypical IkappaB protein Bcl3 is primarily a transcriptional core

68 ice with impaired expression of the atypical IkappaB protein IkappaBNS have markedly reduced frequenc

69 of-function studies reveal that the atypical IkappaB protein, Bcl3, is also required for induction of

70 such as inhibitor of nuclear factor kappa B (IkappaB) kinase alpha (IKKalpha), IKKbeta, and IKKepsilo

71 lve the classical NF-kappaB pathway, because IkappaB-alpha degradation and p65 nuclear translocation

72 RE1A/beta-TrCP is substrate-specific because IkappaB, another substrate of SCF(beta-TrCP), is not sen

73 onstrated by reduction of phospho-IKK-beta, -IkappaB-alpha, and p65 nuclear translocation in ECs.

74 aNp63 expression through its ability to bind IkappaB and enhance nuclear Rel/A p65, a component of th

75 PCA1 blocked IkappaB-alpha degradation, inhibited IKKalpha/beta and I

76 lecule that is an upstream regulator of both IkappaB kinase (IKK) and c-Jun N-terminal kinase (JNK),

77 kappaB system, degradation of NFkappaB-bound IkappaB by the IkappaB kinase (IKK) is required for acti

78 d inhibits its phosphorylation on Ser-209 by IkappaB kinase-beta (IKKbeta).

79 ear transcription factor kappaB (IkappaB) by IkappaB kinase (IKK) triggers the degradation of IkappaB

80 molecular stripping from the DNA induced by IkappaB.

81 sed differentiated phenotype and mediated by IkappaB kinase alpha/NUMB/NOTCH signaling.

82 s involves hypothalamic immunity mediated by IkappaB kinase-beta (IKK-beta), nuclear factor kappaB (N

83 the PKC-alpha/IkappaBalpha- and calcineurin/IkappaB-beta-dependent NF-kappaB signaling pathways are

84 the PKC-alpha/IkappaB-alpha- and calcineurin/IkappaB-beta-dependent NF-kappaB signaling pathways, and

85 alpha/IkappaB-alpha)-mediated or calcineurin/IkappaB-beta-dependent, NF-kappaB-dependent allergen-ind

86 K Binding Kinase 1 (TBK1) is a non-canonical IkappaB kinase that contributes to KRAS-driven lung canc

87 y inhibiting the activation of non-canonical IkappaB kinase varepsilon and IkappaBalpha, and conseque

88 Small-molecule inhibitors of non-canonical IkappaB kinases TANK-binding kinase 1 (TBK1) and IkappaB

89 ligase TRAF6 is a key regulator of canonical IkappaB kinase (IKK)/NF-kappaB signaling in response to

90 Three canonical IkappaBs, IkappaBalpha, IkappaBbeta, and IkappaBepsilon,

91 ignature included "protein kinase cascade," "IkappaB kinase/NFkappaB cascade," and "regulation of pro

92 light polypeptide gene enhancer in B-cells (IkappaB) family.

93 ritive and genetic inhibition of the central IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-

94 Unphosphorylated Bcl3 acts as a classical IkappaB-like inhibitor and removes p50 and p52 from boun

95 Tid1 is an essential mediator that connects IkappaB kinases to the Beclin1-containing autophagy prot

96 on via blocking the degradation of cytosolic IkappaB-alpha and hence, the activation of downstream ma

97 calization signals, and binding to cytosolic IkappaBs are conserved.

98 n and that its deficiency leads to decreased IkappaB turnover in humans, highlighting an important re

99 paired NF-kappaB activation due to decreased IkappaB ubiquitination and degradation.

100 ibited tumor necrosis factor-alpha-dependent IkappaB degradation and expression of proinflammatory me

101 can be triggered by targeting two different IkappaB proteins and that IkappaBepsilon may be an effec

102 biquitin protease OTU domain that diminished IkappaB kinase-dependent phosphorylation and activation

103 ith MHC-I, MyD88-dependent TLR signals drive IkappaB-kinase (IKK)2-mediated phosphorylation of phagos

104 dentified as an interactor of the Drosophila IkappaB factor Cactus and shown to play a role in contro

105 egulates the transcription of the Drosophila IkappaB homolog, Cactus, in Toll receptor-mediated antim

106 ut NF-kappaB activation mechanism emphasizes IkappaB-tethered complex inactivation in the cytoplasm.

107 .1292dupG in exon 13 of IKBKB, which encodes IkappaB kinase 2 (IKK2, also known as IKKbeta)--leading

108 omozygous point mutation in IKBKAP, encoding IkappaB kinase complex-associated protein.

109 ed NF-kappaB by interfering with endothelial IkappaB kinase 2 activity in vitro and in vivo.

110 ndent actin depolymerization, which enhances IkappaB degradation, p65 nuclear translocation, nuclear

111 To further investigate how IkappaB-zeta mediates NF-kappaB activity, we performed i

112 ty and phosphorylation of p65, IkappaBalpha, IkappaB kinase, and Akt.

113 al events lead to the activation of the IKK (IkappaB kinase).

114 t of RIP1 to the receptor complex, impairing IkappaB kinase (IKK) recruitment and NF-kappaB activatio

115 glycerophosphoinositol-dependent decrease in IkappaB kinase alpha/beta, p38, JNK, and Erk1/2 kinase p

116 is factor-alpha expression and a decrease in IkappaB-alpha degradation and nuclear factor-kappaB phos

117 potentiated the TNFalpha-induced increase in IkappaB kinase (IKK) activity, as well as the expression

118 ines with this deletion, exhibited increased IkappaB kinase (IKK) activity and production of proinfla

119 on, and B56gamma silencing induced increased IkappaB kinase (IKK) and IkappaBalpha phosphorylation up

120 coccus faecalis or CpG DNA, led to increased IkappaB cleavage, NF-kappaB nuclear localization, and IL

121 Last, U(L)26 blocks TNF-alpha-induced IkappaB-kinase (IKK) phosphorylation, a key step in NF-k

122 enced by the suppression of particle-induced IkappaB phosphorylation, NF-kappaB p65 nuclear transloca

123 art of a multicomponent complex that induces IkappaB kinase (IKK) activity and NF-kappaB activation.

124 Here, we found that inducible IkappaB kinase-related (IKK-related) kinase IKBKE expres

125 NF-alpha activity was mediated by inhibiting IkappaB kinase phosphorylation, which attenuated the LPS

126 t affecting the degradation of its inhibitor IkappaB-alpha.

127 eins, among which is the NF-kappaB inhibitor IkappaB.

128 ternary complexes with DNA and the inhibitor IkappaB.

129 equestered in the cytosol by their inhibitor IkappaB (inhibitor of NF-kappaB) proteins.

130 ypeptide gene enhancer in B cells inhibitor (IkappaB) zeta (NFKBIZ, the gene encoding IkappaBzeta) wa

131 ing the controlled degradation of inhibitory IkappaB proteins.

132 F-kappaB dimer through binding to inhibitory IkappaB proteins.

133 While aspirin directly inhibits IkappaB kinases (IKKs) to phosphorylate IkappaBalpha for

134 orates renal interstitial fibrosis, inhibits IkappaB/NF-kappaB signaling, and enhances Keap1/Nrf2 sig

135 ncorporated unprotected phosphotyrosine into IkappaB-alpha using a modified gene having a TAG codon i

136 calpains target vertebrate and invertebrate IkappaB proteins.

137 chanism of NF-kappaB induction not involving IkappaB kinase activation.

138 nes encoding IFN regulatory factor 6 (IRF6), IkappaB kinase-alpha (IKKalpha), and stratifin (SFN) exh

139 Central to NF-kappaB activation is IkappaB kinase (IKK), which phosphorylates IkappaBalpha,

140 itor of nuclear transcription factor kappaB (IkappaB) by IkappaB kinase (IKK) triggers the degradatio

141 the inhibitor of the nuclear factor kappaB (IkappaB) kinase family.

142 RF3) and inhibitor of nuclear factor-kappaB (IkappaB) kinase (IKK)/nuclear factor-kappaB (NFkappaB) s

143 Mice lacking the inhibitor of NF-kappaB (IkappaB) kinase (IKK) kinase TAK1 underwent normal posit

144 binding to the NEMO/inhibitor of NF-kappaB (IkappaB) kinase gamma (IKKgamma) subunit of an IKK compl

145 ARD11)-TAK1 (MAP3K7)-inhibitor of NF-kappaB (IkappaB) kinase-beta (IKKbeta) module is a switch mechan

146 We identified the inhibitor of kappaB (IkappaB) kinase (IKK) complex regulatory subunit NEMO [n

147 c process by activating inhibitor of kappaB (IkappaB) kinase (IKK) complex, which subsequently recrui

148 ppaB inhibitor protein, inhibitor of kappaB (IkappaB)alpha, to study the roles of NF-kappaB in the de

149 Other elements of the nuclear factor kappaB/IkappaB cascade (ie, IKK-alpha,-beta,-gamma/NEMO and CAR

150 ter switches such as Nrf2/Keap1 or NF-kappaB/IkappaB is used for system-wide oxidative stress respons

151 phoma cells with inhibitors of the NF-kappaB/IkappaB kinase pathway or deletion of c-Rel or RelA resu

152 rectly binds the NF-kappaB-activating kinase IkappaB kinase subunit gamma (NEMO or NF-kappaB essentia

153 n of the noncanonical IkappaB kinase kinases IkappaB kinase e and TBK1, which are upregulated by over

154 s targeting the NF-kappaB regulatory kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, we find tha

155 We identified the two kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta

156 otif protein similar to insect and mammalian IkappaB, an inhibitor of the transcription nuclear facto

157 additional effect to inhibit RANKL-mediated IkappaB degradation and NF-kappaB activation in osteocla

158 ain A (CalpA) on the Drosophila melanogaster IkappaB homologue Cactus in vivo.

159 at expression of the atypical IkappaB member IkappaB (inhibitor of NF-kappaB) zeta, a selective coact

160 silon), which form low-molecular-weight (MW) IkappaB:NF-kappaB complexes that are highly stable, and

161 Expression of a dominant-negative IkappaB, which blocks NF-kappaB nuclear translocation, p

162 e "molecular stripping" seen in the NFkappaB/IkappaB genetic broadcasting system.

163 lations of a realistic model of the NFkappaB/IkappaB network, we also illustrate the dephasing phenom

164 ophagy factor ATG1/ULK1 and the noncanonical IkappaB kinase (IKK), TANK-binding kinase 1 (TBK1), whic

165 ed in the identification of the noncanonical IkappaB kinase kinases IkappaB kinase e and TBK1, which

166 in persistent elevation of the noncanonical IkappaB kinases IKKepsilon and TBK1.

167 Here, we show that the noncanonical IkappaB-related kinase, IKBKE, is a critical oncogenic e

168 IkappaBzeta, an atypical nuclear IkappaB protein and selective coactivator of particular

169 We describe Pickle, a Drosophila nuclear IkappaB that integrates signaling inputs from both the I

170 Surprisingly, the Bcl3-type nuclear IkappaB proteins functionally pair up only with NF-kappa

171 nvolves an increased nuclear accumulation of IkappaB kinase beta (IKKbeta) and an increased recruitme

172 Activation of IkappaB kinase (IKK) and NF-kappaB by genotoxic stresses

173 ignaling pathway that involves activation of IkappaB kinase and nuclear factor kappaB (NF-kappaB).

174 and is sustained by constitutive activity of IkappaB kinase (IKK) in the cytoplasm.

175 d that knockdown or blocking the activity of IkappaB kinase beta (IKKbeta) prevented the aggregation

176 NEMO affects the activity of IkappaB kinase-beta (IKKbeta), which relieves the inhibi

177 ing the activation and intrinsic activity of IkappaB kinase-beta.

178 , by assessing the kinetics and amplitude of IkappaB kinase (IKK) activation, we report that TNF-alph

179 tors of c-Jun N-terminal kinase (JNK) and of IkappaB kinase (IKK) were used to investigate the involv

180 histone deacetylase activity and blockade of IkappaB kinase/nuclear factor-kappaB signaling during re

181 demonstrated that kinetic considerations of IkappaB kinase-signaling input and IkappaBepsilon's inte

182 2 blocked phosphorylation and degradation of IkappaB and enhanced inhibitory binding of PPARgamma to

183 paB kinase (IKK) triggers the degradation of IkappaB and migration of cytoplasmic kappaB to the nucle

184 IKKgamma, leads to increased degradation of IkappaB and subsequent nuclear translocation of RelA.

185 acilitates ubiquitination and degradation of IkappaB kinase (IKK)-beta thus terminating IKK activity.

186 teracts with and promotes the degradation of IkappaB kinase beta (IKKbeta), a component of the Ikappa

187 e phosphorylation of IKK, the degradation of IkappaB, and augmented the expression of pro-inflammator

188 on of NF-kappaB by endogenous degradation of IkappaB-alpha was observed for HARE(N2280A) cells endocy

189 rase plasmids, as assessed by degradation of IkappaB-alpha.

190 cells by reducing proteasomal degradation of IkappaB.

191 eta-resistant variants, genetic depletion of IkappaB kinase beta (IKKbeta) (activated during hyperamm

192 y reports that neuron-specific expression of IkappaB super-repressor mitigated behavioral and patholo

193 Bcl-3 is an atypical member of the family of IkappaB proteins.

194 an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key kinase in the ca

195 The importance of IkappaB kinase (IKK)-induced proteolysis of NF-kappaB1 p

196 n mice with sepsis and whether inhibition of IkappaB kinase (IKK) reduces the cardiac dysfunction in

197 Chemical inhibition of IkappaB kinase (IKK), mitogen-activated protein extracel

198 tions and detected a physical interaction of IkappaB-zeta with both p50 and p52 NF-kappaB subunits, i

199 Knockdown of IkappaB-zeta by RNA interference was toxic to ABC but no

200 Coexpression of dominant-negative mutants of IkappaB kinase alpha (IKKalpha)/IKK1 or IKKbeta/IKK2 als

201 tabilized NIK, and led to phosphorylation of IkappaB kinase (IKK)-alpha.

202 er demonstrated decreased phosphorylation of IkappaB kinase (IKKbeta) and IkappaBalpha in the presenc

203 The cNOS-mediated reduction of IkappaB is likely due to the imbalance of nitric oxide/p

204 oxide synthase plays a role in regulation of IkappaB reduction and NF-kappaB activation in human kera

205 -kappaB p65 by preventing the resynthesis of IkappaB and increased transcription of KC and IL-6 genes

206 arget genes, indicating an essential role of IkappaB-zeta in regulating a specific set of NF-kappaB t

207 clear translocation via the stabilization of IkappaB is an important mechanism of PI-induced apoptosi

208 e catabolic changes through stabilization of IkappaB-zeta, a critical pro-inflammatory mediator in ch

209 ired either for mitochondrial suppression of IkappaB degradation.

210 There are two types of IkappaB inhibitors: the prototypical IkappaBs (IkappaBal

211 beta-mediated signaling pathways upstream of IkappaB and MAPK activation.

212 TNF-induced NF-kappaB signaling upstream of IkappaB kinase activation absolutely requires the influx

213 d by vorinostat in EOC cells is dependent on IkappaB kinase (IKK) activity and associated with a gene

214 rough PUMA-MPC interaction, which depends on IkappaB kinase-mediated phosphorylation of PUMA at Ser96

215 Hippo kinases MST1, MST2, and the oncogenic IkappaB kinase TBK1 as the most enriched RASSF1A-interac

216 the ability of TLR stimuli to induce optimal IkappaB kinase phosphorylation and nuclear translocation

217 o express either cyclooxygenase-2 (COX-2) or IkappaB kinase-2 (IKK2), and TP53(+/+) or TP53(f/f) spec

218 effect of p53 on ubiquitin-related genes or IkappaB kinases.

219 nd shares low sequence similarity with other IkappaB proteins.

220 expression levels of P65, p-P65, p-MEK and p-IkappaB-alpha were inhibited dose-dependently.

221 anonical and noncanonical NF-kappaB pathways IkappaB kinase beta (IKKbeta) and IKKalpha to activate N

222 d by increased abundance of RelB and phospho-IkappaB kinase alpha/beta, an indirect activator of NF-k

223 (phospho-nuclear factor-kappaB p65, phospho-IkappaB kinase alpha/beta, interleukin 1beta, and tumor

224 phosphorylated NF-kappaB and phosphorylated IkappaB levels in osteoclasts.

225 vels of Nur77, CD5, GITR, and phosphorylated IkappaB-alpha in thymocytes from NODBim(-/-) mice sugges

226 d increased NF-kappaB-p65 and phosphorylated IkappaB-alpha levels along with higher serum levels of T

227 However, phosphorylated IkappaB kinase (IKK)alpha/beta expression and NF-kappaB

228 Unexpectedly, phosphorylated IkappaB-alpha also mediated the exchange of exogenous DN

229 canonical role of IKKbeta in phosphorylating IkappaB to allow NFkappaB activation.

230 equired for TNF-induced IKK phosphorylation, IkappaB degradation, nuclear translocation of NF-kappaB

231 es that are highly stable, and the precursor IkappaBs (p105/IkappaBgamma and p100/IkappaBdelta), whic

232 A20(ZF7) cells exhibited prolonged IkappaB kinase activity that drove exaggerated transcrip

233 In these cells, S1P, but not TNF, promotes IkappaB kinase (IKK) and p65 phosphorylation, IkappaBalp

234 overexpressing NF-kappaB inhibitory protein IkappaB expression, we demonstrate that LPS-induced ET-1

235 specific isoforms of the inhibitory protein IkappaB mediated these diverse responses; NF-kappaB sign

236 Unlike prototypical IkappaB proteins, which are inhibitors of NF-kappaB RelA

237 ypes of IkappaB inhibitors: the prototypical IkappaBs (IkappaBalpha, IkappaBbeta, and IkappaBepsilon)

238 glycogen synthase kinase 3 activity, reduces IkappaB phosphorylation and p65 NF-kappaB translocation,

239 reduced phosphorylative activation, reducing IkappaB kinase-beta activation and intrinsic activity, t

240 onse, highlight the importance of regulating IkappaB/Cactus transcription in innate immunity, and ide

241 C, [Ca(2+)]i, protein kinase C) and requires IkappaB kinase (IKK)-beta.

242 erse the effect of l-NAME in partial restore IkappaB level post-UVB.

243 ished downstream mediators of NIK signaling, IkappaB kinase alpha/beta (IKKalpha/beta) and NF-kappaB,

244 tivity was required for maintaining a stable IkappaB kinase alpha subunit (IKKalpha) level because tr

245 lammatory cytokines TNF and IL-17 stimulated IkappaB kinase (IKK)-NF-kappaB and impaired osteogenic d

246 IRAK2-TRAF6 interaction is needed to sustain IkappaB-inducing kinase beta activity during prolonged a

247 molecule to independently bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

248 r cells and for regulation of its key target IkappaB and hence NF-kappaB.

249 d the effects on HIV activation of targeting IkappaBs by single and pairwise small interfering RNA (s

250 gnaling kinases TANK-binding kinase 1 (TBK1)/IkappaB kinase epsilon (IKKepsilon) on the same serine-7

251 , transforming growth factor beta (TGFbeta), IkappaB kinase (IKK), Ras/mitogen-activated protein kina

252 Collectively, our data demonstrate that IkappaB-zeta is essential for nuclear NF-kappaB activity

253 and in vitro kinase assays demonstrated that IkappaB kinase beta is a key serine/threonine kinase act

254 t genome-wide siRNA screen demonstrated that IkappaB kinase-alpha (IKK-alpha) is a crucial host facto

255 and p52 NF-kappaB subunits, indicating that IkappaB-zeta interacts with components of both the canon

256 Here we report that IkappaB kinase alpha (IKKalpha) is a critical negative r

257 Here, we report that IkappaB kinase beta (IKKbeta) is activated upon glutamin

258 We previously reported that IkappaB kinase alpha (IKKalpha), a component of the kina

259 Previously, we reported that IkappaB kinase-beta(IKKbeta) phosphorylates and stabiliz

260 The IkappaB family protein BCL-3 stabilizes a NF-kappaB p50

261 The IkappaB kinase-NF-kappaB signaling pathway is required f

262 The IkappaB-Kinase (IKK) complex-consisting of the catalytic

263 ntial role in inflammation by activating the IkappaB kinase (IKK)/nuclear factor kappaB (NF-kappaB) a

264 ough the innate immune receptor MDA5 and the IkappaB kinase-beta-NF-kappaB pathway.

265 ppaBbeta, and IkappaBepsilon, exist, but the IkappaB proteins' role in HIV activation regulation is n

266 al is sequestered outside the nucleus by the IkappaB homolog Cactus.

267 degradation of NFkappaB-bound IkappaB by the IkappaB kinase (IKK) is required for activation in respo

268 f a number of cellular factors including the IkappaB kinase epsilon (IKKepsilon).

269 ts activation of NF-kappaB by inhibiting the IkappaB kinase pathway and by promoting direct inhibitor

270 Manipulating the IkappaB kinase beta activity coupled with in vivo and in

271 Bcl-3 is an atypical member of the IkappaB family and modulates gene expression via interac

272 Bcl-3 is an atypical member of the IkappaB family that modulates transcription in the nucle

273 athway activation induces degradation of the IkappaB inhibitor Cactus, resulting in a ventral-to-dors

274 This is achieved through subversion of the IkappaB kinase (IKK) complex (or signalosome), which inv

275 aB kinase beta (IKKbeta), a component of the IkappaB kinase (IKK) complex that regulates nuclear fact

276 DRAIC interacted with subunits of the IkappaB kinase (IKK) complex to inhibit their interactio

277 ulator (NEMO), a regulatory component of the IkappaB kinase (IKK) complex, controls NF-kappaB activat

278 aB essential modulator (NEMO) subunit of the IkappaB kinase (IKK) complex.

279 a complex with the modulatory subunit of the IkappaB kinase (IKK) kinase, IKKgamma (or NEMO), resulti

280 dulator (NEMO; the regulatory subunit of the IkappaB kinase [IKK] complex).

281 miR-148a is an inhibitor of the IkappaB kinase alpha/NUMB/NOTCH pathway and an inducer o

282 Inhibition of the IkappaB kinase complex (IKK) has been implicated in the

283 Selective autophagic degradation of the IkappaB kinase complex prevents constitutive activation

284 s process occurred through activation of the IkappaB kinase complex, which also led to activation of

285 cytoplasm through the kinase activity of the IkappaB kinase complex, which leads to translocation of

286 eceptor that mediates the degradation of the IkappaB kinase complex.

287 ecifically suppressing the activation of the IkappaB kinase complex.

288 pression by decreasing the activation of the IkappaB-kinase beta-RelA NF-kappaB pathway.

289 g NF-kappaB signaling via its effects on the IkappaB kinase complex and resulting in reduced IL2 gene

290 ay and exerts its function by recruiting the IkappaB kinases (IKK) to the IKK complex.

291 e synthase (cNOS), can partially reverse the IkappaB reduction and inhibit the DNA binding activity a

292 We previously found that the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway regulate

293 Consistent with this, the IkappaB kinase inhibitor BAY11-7085 and dominant-negativ

294 MC005 inhibited NF-kappaB proximal to the IkappaB kinase (IKK) complex, and unbiased affinity puri

295 rculosis demonstrated robust release of TNF, IkappaB degradation, and NF-kappaB nuclear translocation

296 at serine 428, which promoted its binding to IkappaB kinasebeta (IKKbeta), resulting in the inhibitio

297 activated CaMKII in cardiomyocytes leads to IkappaB kinase phosphorylation and concomitant increases

298 Inhibition or deletion of the upstream IkappaB kinase substantially reduced SINV replication in

299 uced activation of TAK-1 and ERK1/2, whereas IkappaB kinase and IkappaB were phosphorylated, even in

300 cilitated the complex formation of CD91 with IkappaB kinases (IKKs) alpha and beta and increased the