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1 ntaining a peptide called the joining chain (J chain).
2 d provide a supersymmetric analogue of the t-J chain.
3 creted IgM, polymeric Ig receptor (pIgR), or J chain.
4  with recombinant baculovirus containing the J chain.
5 is present as high order polymers containing J chain.
6 (alpha)2 is also present; the dimers contain J chain.
7 avy) chain and one glycosylation site on the J chain.
8  pentamers with J chain and hexamers lacking J chain.
9 , polymeric IgA exists mostly as dimers with J chain.
10 ubunit interacting most extensively with the J-chain.
11 y the Cmu4 and Cmu3 constant regions and the J-chain.
12  glycan sites on the mu chain and one on the J-chain.
13 he latter additionally containing a joining (J) chain.
14                                              J chain also is required for poly-Ig receptor-mediated t
15 cation of this ancestral affiliation between J chain and CXCL chemokines addresses an age-old problem
16 hat approximately 15% of plasma pIgA carried J chain and displayed selective SC binding capacity eith
17         IgM is assembled into pentamers with J chain and hexamers lacking J chain.
18 sufficient to regulate BSAP targets CD19 and J chain and is necessary but not sufficient to induce XB
19 upregulates the expression of syndecan-1 and J chain and represses that of c-myc.
20 s contain IgM multimers that incorporate the J chain and resist degradation by endoglycosidase H, arg
21                         Expression of the Ig J chain and the secreted form of Ig mu, which are both k
22 s from the covalent assembly of one joining (J) chain and 5 IgM subunits into an asymmetric "pentamer
23 ilpiece is involved in interactions with the J-chain and the Polymeric Immunoglobulin Receptor, and i
24 lphatp is present mainly as hexamers lacking J chain, and mumugammamu-utp forms tetramers and hexamer
25 ged mice, associated with elevated levels of J chain, and secretion of IgM.
26 xtinguished genes include those encoding Ig, J chain, and the transcription factors Oct-2, PU.1, and
27 mine the allergic diarrhea susceptibility of J chain- and polymeric immunoglobulin receptor-deficient
28 stent with this, chicken ovalbumin-immunized J chain- and polymeric immunoglobulin receptor-deficient
29                        In mice and chickens, J chain appears to be expressed only in activated B cell
30 munoglobulin gene products such as mu(s) and J chain as well as the loss of the transcriptional regul
31 eposited IgA has been reported as polymeric, J chain associated, and often, hypogalactosylated but wi
32 rachain disulfide bonds and extension of the J chain C terminus.
33  for their transport into the lumen, pIgR or J chain, cleared C. rodentium normally.
34 s interact with the Fcmu constant region and J chain components of the IgM core.
35 t chains in monomeric as well as in joining (J)-chain containing dimeric IgA.
36 fine the composition of circulatory IgM as a J-chain containing pentamer, always in complex with CD5L
37 reported to be required for binding of human J chain-containing IgA to secretory component.
38 f undergalactosylated, mostly polymeric, and J chain-containing IgA1 and IgG antibodies specific for
39           Following nonmucosal VRP delivery, J chain-containing, polymeric IgA Abs were detected in t
40 erum) IgM exclusively exists as a complex of J-chain-containing pentamers covalently bound to the sma
41 lveolar lavage IgA levels were higher in the J chain-deficient animals.
42                     Further, we suggest that J chain-deficient IgA is transported into secretions by
43 etions was polymeric while the secretions of J chain-deficient mice contained IgA monomers and other
44       Notably, wild-type, alpha1KI, and even J chain-deficient mice showed increased polymeric serum
45 e have previously reported the generation of J chain-deficient mice.
46 d glandular secretions were not depressed in J chain-deficient mice.
47  was associated with SC in wild-type but not J chain-deficient mice.
48 des the demonstration that binding of IgM is J chain dependent, and that pIg-precipitated receptor ha
49  Ig itself and human-like adaptive immunity, J chain emerged in jawed vertebrates (gnathostomes), but
50 cantly decrease J chain promoter activity in J chain expressing B cell lines.
51                 At the low levels present in J chain-expressing plasma cells, BSAP repression could b
52  sorting and examined each subpopulation for J chain expression by reverse transcriptase-PCR.
53 sed mainly on transformed cells suggest that J chain expression may initiate during earlier stages in
54                                              J chain expression occurred in most cells irrespective o
55                            Conservation with J chains from other species is relatively poor, especial
56                                          The J chain gene (JCHAIN) is linked to clustered CXCL chemok
57 leukin-2 (IL-2)-induced transcription of the J chain gene as a model system.
58 owed that BSAP mediates the silencing of the J chain gene during the early stages of B cell developme
59 rmine whether IL-2 signals are targeted to a J chain gene enhancer as well as to its promoter, the se
60 anscription factor PU.1 positively regulates J chain gene expression by binding to one of the control
61 ts as a stage-specific positive regulator of J chain gene expression in the B cell lineage.
62                               Immunoglobulin J chain gene expression is induced by the delivery of a
63 e BCL1 with IL-2 or IL-5 (which up-regulates J chain gene expression) resulted in an increased expres
64 stent with its role as positive regulator of J chain gene expression, B-MEF2 levels were enhanced in
65                           The immunoglobulin J chain gene is inducibly transcribed in mature B cells
66               These results suggest that the J chain gene is transcriptionally active during early st
67 ctor, named B-MEF2, positively regulates the J chain gene promoter activity via the second control el
68 versed the positive regulation and inhibited J chain gene transcription.
69 leukin-2 (IL-2)-induced transcription of the J chain gene was used as a model for analyzing cytokine
70  to its promoter, the sequences flanking the J chain gene were first examined for DNase I hypersensit
71 ied, two strong ones, 7.5 kb upstream of the J chain gene, were found to be associated with an enhanc
72         The putative orthologue of mammalian J chain has been identified in the nurse shark by sequen
73                                              J chain has been proposed to play a role in the mucosal
74   Compared with most other immune molecules, J chain has not been studied extensively, in part becaus
75 rm, suggesting that the reported presence of J chain in invertebrates should be reassessed.
76             In this short review, we discuss J chain in light of the various proposed models of its e
77 in the spiral valve (intestine) suggest that J chain in nurse sharks may not have a role in Ig secret
78 omains are critical for polymer assembly and J chain incorporation.
79                                          The J-chain interacts with the hydrophobic beta-sheets selec
80              Here, we show unexpectedly that J chain is a member of the CXCL chemokine family.
81                                              J chain is a small polypeptide covalently attached to po
82                                        Thus, J chain is not essential for IgA transport by intestinal
83                  However, integration of the J chain is not required for IgM assembly and in its abse
84 e only highly conserved segment in all known J chains is a block of residues surrounding an N-linked
85                               Joining chain (J chain) is a small polypeptide that regulates multimeri
86 L2 subunits and an additional protein termed J-chain (JC), which allows transcytosis across epithelia
87 lso extracted a coupling within the chain of J(chain)/ k(B) = -2.2 K and a coupling between the chain
88                                              J chain knockout mice were readily protected by heterosu
89           Even the reported phenotype of the J chain-knockout mouse is often misunderstood or underap
90  study, we demonstrate that FCRL4 recognizes J chain-linked systemic IgA in the absence of heat aggre
91 her, these data suggest that while the VH6-D-J chain may be important in the binding to beta 2GP-1, p
92                                          The J chain message was not detected in peripheral CD3+ T ce
93                                              J chain mRNA was also detected during fetal thymocyte de
94 ly reported sequence of functionally spliced J chain mRNA.
95 tly induce Blimp-1, X box-binding protein-1, J chain, or secretory Ig mu transcripts but express IFN-
96                   The nucleotide sequence of J chain PCR products from CD34+/CD19- bone marrow progen
97  isotype, despite the documented presence of J chain(-) plasma cells in mammals, specifically in all
98 relationship exists between USF and a second J chain positive-regulating factor, B-MEF2, using co-imm
99  different cell types with heavy, light, and J chains produced by the plasma cells, whereas secretory
100 the USF binding motif significantly decrease J chain promoter activity in J chain expressing B cell l
101 nts USF and B-MEF2 from interacting with the J chain promoter during the antigen-independent stages o
102 sitive-acting factors binding to down-stream J chain promoter elements.
103 mediately upstream from the BSAP site on the J chain promoter.
104 g to one of the control elements (JB) in the J chain promoter.
105 ntrol elements (JA and JB) exists within the J chain promoter.
106 nt of MEF2C blocked B-MEF2 regulation of the J chain promoter.
107 ecognizes a negative regulatory motif in the J chain promoter.
108 erally assumed that all plasma cells express J chain regardless of expressed isotype, despite the doc
109                                 The joining (J) chain regulates polymerization of multimeric Immunogl
110            Formation of pentamers containing J chain requires C(mu)3, C(mu)4, and the mutp.
111                                  Analysis of J chain sequences in diverse species is in agreement wit
112              Crystal structures of CXCL8 and J chain share a conserved beta-strand core but diverge o
113 carboxyl-terminal portion, and, unlike other J chains, the shark protein is not acidic.
114 ine residues that are conserved in mammalian J chains, three are lacking in the nurse shark, includin
115 ly different, likely due to modifications in J chain to direct Ig polymerization and mucosal transpor
116 (BSAP), a transcription factor that silences J chain transcription, has been identified as a nuclear
117 ir respective promoter elements and activate J chain transcription.
118 r with these data, the relative abundance of J chain transcripts in the spleen and their absence in t
119              In fetal and adult bone marrow, J chain transcripts were detected at all stages of B lin
120 amu-utp forms tetramers and hexamers lacking J chain, whereas IgA-mutp is present as high order polym
121 e observations were made in mice lacking the J chain, which is required for pIgR-dependent transepith
122 been suggested, we studied dependence on the J chain, which is required for polymeric Ig receptor-med

 
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