ライフサイエンスコーパス: JAK-STAT pathway

1 egulate cytokine signaling by inhibiting the JAK-STAT pathway.

2 used in leukocytes: the ITAM pathway and the Jak-STAT pathway.

3 r of IFN-alpha-induced signaling through the Jak-STAT pathway.

4 nd negatively regulate signaling through the JAK-STAT pathway.

5 restricts WNV infection by activation of the Jak-STAT pathway.

6 y reduced SOCS5 levels, leading to activated JAK-STAT pathway.

7 addition, LOS-induced IFN-beta activated the JAK-STAT pathway.

8 t, blocking type I IFN signaling through the JAK-STAT pathway.

9 tors of cytokine receptors that activate the JAK-STAT pathway.

10 e originally identified as inhibitors of the JAK-STAT pathway.

11 downregulation of several components in the JAK-STAT pathway.

12 fied as transcriptional co-regulators of the JAK-STAT pathway.

13 d), which encodes the secreted ligand of the JAK-STAT pathway.

14 urrently available mechanistic models of the JAK-STAT pathway.

15 ogical pathways, such as IL-6 signalling via JAK-STAT pathway.

16 was independent of the classical IFN-induced JAK-STAT pathway.

17 nner that was dependent on activation of the JAK/STAT pathway.

18 in genes encoding PAX5 and components of the JAK/STAT pathway.

19 its endocytosis, whereas JAK2 initiates the JAK/STAT pathway.

20 at are well-known negative regulators of the JAK/STAT pathway.

21 es involved in chromatin modification or the JAK/STAT pathway.

22 OCS) proteins are feedback inhibitors of the JAK/STAT pathway.

23 hat IL-6 induces IDO1 expression through the JAK/STAT pathway.

24 demonstrate a new neuronal function for the JAK/STAT pathway.

25 al signaling, but not the interferon-induced JAK/STAT pathway.

26 of multiple signaling pathways including the JAK/STAT pathway.

27 regulating the innate immune response is the JAK/STAT pathway.

28 pinal NMDA receptor and IL-1beta through the JAK/STAT pathway.

29 xpression or number and does not involve the JAK/STAT pathway.

30 o gain-of-function mutants in the Drosophila JAK/STAT pathway.

31 he Stat family of signal transducers via the Jak/Stat pathway.

32 or to the furrow, indicating function of the Jak/STAT pathway.

33 ess of the mutational status of genes in the JAK/STAT pathway.

34 r targeting shared downstream factors of the JAK/STAT pathway.

35 pregulating Claudin-2 expression through the JAK/STAT pathway.

36 nti-STAT3, suggesting the involvement of the JAK/STAT pathway.

37 to primary tumors, and is dependent upon the Jak/Stat pathway.

38 ia into MGPCs in the zebrafish retina is the Jak/Stat-pathway.

39 constitutive activation of the Janus kinase (JAK)/STAT pathway.

40 these genes are linked to the Janus kinase (JAK)/STAT pathway.

41 hogenetic protein (BMP) and the inflammatory JAK-STAT pathways.

42 dent mechanisms and the MAPK, NF-kappaB, and JAK-STAT pathways.

43 nes are distinct from those regulated by the JAK-STAT pathways.

44 transducers and activators of transcription (JAK-STAT) pathway.

45 l transducer and activator of transcription (JAK-STAT) pathway.

46 l transducer and activator of transcription (JAK-STAT) pathway.

47 l transducer and activator of transcription (JAK-STAT) pathway.

48 ediated sequential activation of the Src and JAK/STAT pathways.

49 ctive downregulation mechanism in EOS(A) for JAK/STAT pathways.

50 ansion and expansion/survival cytokines, and JAK/STAT pathways.

51 genes and was able to inhibit NF-kappaB and JAK/STAT pathways.

52 and survival, type I interferon (IFN-I), and JAK/STAT pathways.

53 transducers and activators of transcription (JAK/STAT) pathway.

54 ired (upd) encodes a secreted ligand for the JAK/STAT pathway [5-7].

55 te these critical upstream components of the Jak-Stat pathway, achieving inhibition of Stat phosphory

56 The Hh and JAK/STAT pathways act independently and non-redundantly

57 OCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines,

58 However, the role of JAK-STAT pathway activation in different MPNs, and in pa

59 These results suggested that JAK-STAT pathway activation might contribute to the path

60 Surprisingly, both JAK/STAT pathway activation and ruxolitinib efficacy wer

61 ed (IKK-related) kinase IKBKE expression and JAK/STAT pathway activation compose a cytokine signaling

62 pegIFN-alpha is not the result of prolonged Jak/STAT pathway activation in hepatocytes, but rather i

63 The HEL cell line, in which constitutive JAK/STAT pathway activation is caused by JAK2V617F, was

64 L1 expression in HNC cells in the context of JAK/STAT pathway activation, Th1 inflammation, and HPV s

65 bitor SOCS3 cooperates with IL-6 to maintain JAK/STAT pathway activation, thus contributing to leukem

66 herd's crook shape is dependent on localised JAK/STAT pathway activation.

67 ry of 2000 small molecules for modulators of JAK/STAT pathway activation.

68 lasms by identifying compounds that suppress JAK/STAT pathway activation.

69 ells (ISCs) by stimulating Wingless (Wg) and JAK/STAT pathway activities, whereas cytokine production

70 We show that JAK-STAT pathway activity, which declines from posterior

71 nstrate that Et/Lat negatively regulates the JAK/STAT pathway activity and can bind to Dome, thus red

72 lass II receptor families and the downstream JAK-STAT pathway along with its key negative regulators.

73 Manipulations of the JAK/STAT pathway also disrupt circadian rhythms.

74 To understand whether the JAK/Stat pathway also regulates cardiogenesis, we perfor

75 The Wnt/beta-catenin and JAK/STAT pathways, altered in 62.5% and 45.5% of cases,

76 The G-CSF receptor (G-CSFR) activates the Jak/STAT pathway, although little is understood about ho

77 ified as strong inhibitors of the Drosophila JAK/STAT pathway, an effect conserved to human cells.

78 o leptin with activation of an intracellular JAK-STAT pathway and a reduction in firing rate.

79 g new evidence supporting a link between the JAK-STAT pathway and cadherin-based cell-cell interactio

80 s' laboratory has shown how mutations in the JAK-STAT pathway and epigenetic regulators play a role i

81 n vitro, further supporting the roles of the JAK-STAT pathway and herpesviruses in mediating the adve

82 terferon receptors, interferon activates the JAK-STAT pathway and results in the positive feedback of

83 emonstrate a dichotomy between the classical JAK-STAT pathway and the NF-kappaB signaling pathway.

84 IFN receptor (IFNAR), there is activation of Jak-Stat pathways and also engagement of Mnk kinases.

85 lements both the transcriptional activity of Jak-STAT pathways and controls initiation of mRNA transl

86 that is down-regulated by inhibitors of the JAK/STAT pathway and enhanced by inhibitors of the Src k

87 ons of CNA encompassed genes involved in the JAK/STAT pathway and epigenetic regulators.

88 ting form of SOCS3 (CP-SOCS3) to inhibit the JAK/STAT pathway and prevent cytokine-mediated lethal in

89 y of these proteins thus interfering with he JAK/STAT pathway and reducing their ability to inhibit t

90 of lens cell proliferation by inhibitors of JAK/STAT pathways and by the aberrant proliferation of l

91 These tumors have activated JAK/STAT pathways and expression of interferon-stimulate

92 ts, including the Ras/Raf/Erk, PI3K/Akt, and JAK/STAT pathways and immune checkpoint receptors.

93 red independently of the IL-15/IL-2Rbeta and Jak/STAT pathways and instead required IL-15Ralpha signa

94 fects of IL-21R arose from signaling through JAK/STAT pathways and upregulation of caspase 3.

95 l transducer and activator of transcription (JAK/STAT) pathway and enhanced the expression of IFN reg

96 ype I, II, and III IFNs, signals through the JAK-STAT pathway, and plays central roles in host defens

97 nd IL-22-induced phosphorylation of MAPK and JAK-STAT pathways, and activation of the NF-kappaB pathw

98 meiotic cohesin complex, via a non-canonical JAK/STAT pathway, and consequently promotes meiotic DSB

99 eins are negative-feedback regulators of the JAK/STAT pathway, and SOCS3 contributes to host immunity

100 okines that are elevated in HLH activate the JAK/STAT pathway, and the JAK1/2 inhibitor ruxolitinib (

101 relationships, such as connection within the JAK/STAT pathway, and was further validated in character

102 ading to apoptotic cell death, NF-kappaB and JAK/STAT pathways, and inflammasome-assembly mediating i

103 iviral responses, components of the Toll and JAK/STAT pathways, and serine protease inhibitors in bot

104 The JAK-STAT pathway appears to be activated in all myelopro

105 contrast, the antiviral contribution of the JAK-STAT pathway appears to be virus specific.

106 difications mentioned above to the canonical JAK-STAT pathway are necessary to reproduce this behavio

107 It is known that the BMP and JAK-STAT pathways are necessary for the maintenance of G

108 Cell-cycle and JAK-STAT pathways are significantly altered in lung canc

109 d, but mutations affecting the NF-kappaB and JAK/STAT pathways are frequent.

110 ted over the past decade have shown that the JAK/STAT pathways are involved in GH signaling to the nu

111 We also found that TGFbeta and Jak/Stat pathways are necessary but not sufficient for t

112 F produces CXCL13 and that the NF-kappaB and JAK/STAT pathways are required to induce the expression

113 e, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described.

114 nvasiveness, and migration and implicate the JAK/STAT pathway as a critical mediator of leptin action

115 is suggests the feasibility of targeting the JAK/STAT pathway as a neuroprotective therapy for neurod

116 els of MS, suggesting the feasibility of the JAK/STAT pathway as a target for neuroinflammatory disea

117 fferentiation through convergence on the LIF/JAK-STAT pathway at the level of STAT3.

118 r type I IFN signaling by downregulating the JAK-STAT pathway at the level of the IFN receptor.

119 eral small-molecule inhibitors targeting the JAK/STAT pathway blocked proliferation elicited by IL-2

120 on of genes involved in RNAi, Toll, Imd, and JAK-STAT pathways, but the majority of differentially ex

121 , SOCS proteins are not only induced via the JAK/STAT pathway, but are also transcribed on triggering

122 eins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated ST

123 intron, and is induced by the IFN-triggered Jak-STAT pathway by binding of the IFN-stimulated gene f

124 PN significantly decreases the JAK-STAT pathway by reducing levels of phosphorylated ST

125 ese changes result from a disturbance of the JAK/STAT pathway by hypoxia, and (3) identify JAK/STAT s

126 Here, we pursue STRA13 involvement in the JAK/STAT pathway by studying its role in STAT1 expressio

127 Activation of the JAK/STAT pathway by the IL-6 family of cytokines is the

128 rs complements the function of IFN-activated JAK-STAT pathways, by allowing mRNA translation of IFN-s

129 o These results indicate that inhibiting the JAK/STAT pathway can prevent neuroinflammation and neuro

130 ization was accompanied by activation of the JAK/STAT pathway, commonly seen in megakaryocytic malign

131 bit enhanced and prolonged activation of the JAK/STAT pathway compared with macrophages from SOCS3(fl

132 ese included components of the Toll, Imd and JAK/STAT pathways, consistent with interactions between

133 e controlled by the evolutionarily conserved JAK-STAT pathway contributes to the antiviral host defen

134 how cross-coupling between the CREB/CRTC and JAK/STAT pathways contributes to BM homeostasis.

135 ervations suggest that autoregulation of the Jak-STAT pathway controls the onset of astrogliogenesis.

136 The JAK/STAT pathway controls many developmental events, inc

137 The JAK-STAT pathway critically regulates T-cell differentia

138 of autocrine interleukin-10, which activates JAK/STAT pathway-dependent tyrosine phosphorylation of S

139 transducers and activators of transcription (JAK/STAT) pathway determines cell fates by regulating ge

140 first documentation that suppression of the JAK/STAT pathway disrupts the circuitry of neuroinflamma

141 NTF receptor) and AG490 (an inhibitor of the JAK/STAT pathway downstream of CNTF signalling).

142 s, suggesting that PIV-3 interferes with the JAK/STAT pathway downstream of the IFN-lambdaR1/IL-10R2

143 Constitutive activation of the JAK/STAT pathway downstream of Unpaired partially rescue

144 is the first to characterize a role for the JAK/Stat pathway during cardiogenesis and identifies an

145 The JAK-STAT pathway exerts its anti-Anaplasma activity pres

146 The JAK-STAT pathway exerts its anti-dengue activity presuma

147 landscape of SS and a role for inhibition of JAK/STAT pathways for the treatment of SS.

148 function of CySCs is solely attributable to JAK/STAT pathway function.

149 ion, focusing on Drosophila and highlighting JAK/STAT pathway functions in proliferation, survival an

150 ly understood, although the cytokine-induced Jak-STAT pathway has been postulated to regulate astrogl

151 Inhibition of the JAK/STAT pathway has clinical efficacy in multiple precl

152 Dysregulation of the JAK/STAT pathway has pathological implications in autoim

153 The JAK/STAT pathway has pleiotropic roles in animal develop

154 2V617F mutation, additional mutations in the JAK-STAT pathway have been discovered including a series

155 s that control their actions, members of the Jak-Stat pathway, ideal targets for pharmacological inte

156 rmine the role of the Janus tyrosine kinase (JAK)-STAT pathway in NF-kappaB activation by IFN, we exa

157 cretion of one or more factors activates the JAK-STAT pathway in an auto/paracrine manner.

158 s BCR-ABL, underscores the importance of the JAK-STAT pathway in both normal cellular development and

159 s and thereby stimulated the activity of the JAK-STAT pathway in intestinal stem cells.

160 demonstrating the central importance of the JAK-STAT pathway in MPN pathogenesis.

161 udies identified additional mutations in the JAK-STAT pathway in some patients with JAK2V617F(-) MPD,

162 results implicate the inflammatory IFN-alpha/Jak-Stat pathway in the developmental maturation of embr

163 li cell co-cultures, and direct study of the JAK-STAT pathway in these models and in L cells transfec

164 e decreases and demonstrated the role of the JAK-STAT pathway in vivo during PN.

165 We summarize how the Jak-Stat pathways in these cells are negatively regulate

166 Although the roles of Jak-Stat pathways in type I and II interferon (IFN)-depe

167 l Transducer and Activator of Transcription (JAK-STAT) pathway in two adjacent types of stem cells: g

168 that GPR45 regulates POMC expression via the JAK/STAT pathway in a cell-autonomous manner.

169 okine signaling (SOCS) which can inhibit the JAK/STAT pathway in a classical negative-feedback manner

170 Given the importance of the JAK/STAT pathway in activating microglia and inducing cy

171 ndered whether BCR stimulation activates the JAK/STAT pathway in CLL cells.

172 a new valuable tool to study the role of the JAK/STAT pathway in disease development.

173 by deregulation of several components of the Jak/STAT pathway in early carcinogenesis, then upregulat

174 re we demonstrate aberrant activation of the JAK/STAT pathway in ETP-ALL blasts relative to non-ETP T

175 potential therapeutic value of targeting the JAK/STAT pathway in lymphoma in the clinical setting.

176 in a male-specific manner, and activates the JAK/STAT pathway in male germ cells at the time of gonad

177 In vitro, alpha-SYN exposure activated the JAK/STAT pathway in microglia and macrophages, and treat

178 the therapeutic potential of inhibiting the JAK/STAT pathway in models of EAE.

179 y is the first to demonstrate a role for the JAK/STAT pathway in regional specification by acting ant

180 The findings implicate the JAK/STAT pathway in the pathogenesis of APL and illustra

181 ast 5 wpi, revealing active signaling of the Jak/STAT pathway in these cells.

182 nstrate the ubiquitous activation of Ras and Jak/Stat pathways in HCC and suggest the potential use o

183 Suppression of Ras and Jak/Stat pathways in HCC cell lines was evaluated by via

184 l Transducer and Activator of Transcription (Jak/STAT) pathway in the stem cells.

185 l transducer and activator of transcription (JAK/STAT) pathways in MMP induction by B. burgdorferi.

186 transducers and activators of transcription (JAK/STAT) pathway, in adult retinal ganglion cells (RGCs

187 (59%) showed mutations in >=1 member of the JAK/STAT pathway, including STAT3 (38%), JAK1 (18%), and

188 Furthermore, F-actin is regulated by the Jak/STAT pathway-increasing or decreasing pathway activi

189 Such indirect activation of the Jak-Stat pathway induced by the interaction between an R

190 Our findings document that inhibition of the JAK/STAT pathway influences both innate and adaptive imm

191 Our findings suggest that JAK-STAT pathway inhibition may represent a therapeutic

192 Methotrexate might bring the benefits of JAK/STAT pathway inhibition at a lower cost.

193 However, unlike common JAK-STAT pathway inhibitors, BRD0476 inhibits JAK-STAT s

194 In addition, mutations in the Jak/STAT pathway interact genetically with the Notch pat

195 ding the crucial components of the gliogenic JAK-STAT pathway is accelerated in Dnmt1-/- NPCs.

196 Notably, the JAK-STAT pathway is altered by KLF4, with increased phos

197 The JAK-STAT pathway is an evolutionarily conserved signal t

198 Infection-induced JAK-STAT pathway is both required and sufficient for dif

199 The JAK-STAT pathway is critical in mediating signaling of a

200 Although the discovery of mutations in the JAK-STAT pathway is important from a pathogenetic and di

201 ssential to cytokine receptor signaling, the JAK-STAT pathway is one of the best understood signal tr

202 Our data suggest that the JAK-STAT pathway is part of the A. aegypti mosquito's an

203 The JAK-STAT pathway is proposed to be regulated through dir

204 Previous genetic studies showed that the JAK-STAT pathway is required for full activation of the

205 The mitogenic JAK-STAT pathway is strongly and specifically activated

206 Cytokine signaling by the Jak-STAT pathway is subject to complex negative regulati

207 es in salivary glands and hemolymph when the JAK-STAT pathway is suppressed by RNA interference.

208 to dengue virus infection increases when the JAK-STAT pathway is suppressed through RNAi depletion of

209 The JAK-STAT pathway is the major mediator of these biologic

210 tors discovered in cytokine signaling of the JAK-STAT pathway is the suppressor of cytokine signaling

211 The JAK/STAT pathway is a conserved metazoan signaling syste

212 The JAK/STAT pathway is a highly conserved regulatory module

213 The JAK/STAT pathway is altered in T-cell large granular lym

214 The JAK/STAT pathway is critical for development, regulation

215 established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in t

216 Furthermore, the JAK/STAT pathway is necessary for male-specific germ cel

217 uction of IFN-beta mRNA or activation of the Jak/STAT pathway is not seen.

218 We conclude that activation of the Jak/Stat pathway is the primary mechanism for IFN-gamma-

219 The JAK/STAT pathway is used by numerous cytokines for signa

220 nversely, cytokine signaling through cognate Jak/STAT pathways is reportedly unaffected or even stimu

221 Transducers and Activators of Transcription (JAK/STAT) pathway is aberrantly activated and contribute

222 l transducer and activator of transcription (JAK/STAT) pathway is one of the key signaling cascades i

223 SOCS2, a feedback inhibitor of JAK-STAT pathways, is expressed in most primitive HSC an

224 ncomitant genomic alterations activating the JAK-STAT pathway (JAK1, JAK2, IL7R) identified in 63 pat

225 e showed an increased activation of the IL-6-JAK-STAT pathway leading to a systemic lupus erythematos

226 utocrine and paracrine signaling through the JAK-STAT pathway, leading to the transcriptional inducti

227 transducers and activators of transcription (JAK/STAT) pathway, leading to elevated transcription of

228 eling process, demethylation of genes in the JAK-STAT pathway leads to an enhanced activation of STAT

229 This initial description of the JAK-STAT pathway led quickly to additional discoveries t

230 leads to ectopic production of the mitogenic JAK-STAT pathway ligand Unpaired, which is secreted from

231 division by repressing the expression of the JAK-STAT pathway ligand Upd3 in differentiating enterobl

232 ell reservoir: through Imd signaling and the Jak/Stat pathway ligand Upd3, hemocytes act as sentinels

233 ions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, d

234 ed stem cell proliferation and expression of Jak/Stat pathway ligands.

235 l transducer and activator of transcription (Jak-STAT) pathway maintains stem cells; germline stem ce

236 ur findings provide direct evidence that the JAK/STAT pathway mediates a key signal from the somatic

237 Although the JAK/STAT pathway mediates lymphokine-induced transcripti

238 se activity and increased phosphorylation of JAK-STAT pathway members.

239 efficacy were independent of the presence of JAK/STAT pathway mutations, raising the possibility that

240 The action of neither the Jak-STAT pathway nor the NF-kappaB pathway was required

241 vestigate the possible role of TNF-alpha and JAK/STAT pathway on de novo lipogenesis and PCSK9 expres

242 ited by blockade of the NF-kappaB, PI3K, and JAK-STAT pathways or the presence of neutralizing anti-I

243 l transducer and activator of transcription (JAK-STAT) pathways, or indirectly via changes in the tum

244 the virus when the negative regulator of the JAK-STAT pathway, PIAS, is silenced.

245 gamma receptor-dependent cytokines and their JAK/STAT pathways play pivotal roles in T cell immunity.

246 These data suggest that the Jak/STAT pathway plays a prominent role in PSC prolifera

247 f complementary approaches, we show that the JAK/STAT pathway plays an essential role in the inductio

248 However, we show that the JAK/STAT pathway plays an important role in patterning t

249 ytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates al

250 Importantly, inhibition of the JAK/STAT pathway prevented the degeneration of dopaminer

251 ics of GSCs, while ectopic activation of the Jak-STAT pathway prevents differentiation.

252 receptor (IL-7R), via its activation of the JAK-STAT pathway, promotes gene programs that change dyn

253 l transducer and activator of transcription (JAK/STAT) pathway provides a sex-specific signal from th

254 In addition, inhibition of the JAK/STAT pathway reduces IVNV.

255 identified, and partially characterized, two JAK-STAT pathway-regulated and infection-responsive deng

256 Furthermore, we show that the JAK/STAT pathway regulates a small enhancer in the wg 3'

257 These results demonstrate that the JAK/STAT pathway regulates cellular epigenetic status an

258 E loss-of-function alleles, we show that the JAK/Stat pathway regulates tin expression prior to heart

259 l transducer and activator of transcription (JAK/STAT) pathway regulates the anterior posterior axis

260 We characterize the Drosophila JAK/STAT pathway regulator SOCS36E and show that it func

261 mphoma (DLBCL), we observed higher levels of JAK/STAT pathway-related serum cytokines (ie, IL-6, IL-1

262 or STAT transcription factors of the Imd and Jak-STAT pathways, respectively.

263 ssibly in AM by activating the NF-kappaB and JAK/STAT pathways, respectively.

264 , IRF3, Tbk1, extracellular IFNbeta, and the Jak-Stat pathway resulted in reduced activity of GCV and

265 e culture sections through activation of the JAK/STAT pathway, resulting in increased activity of iNO

266 , whereby IFN-alpha/beta signals through the Jak/STAT pathway, resulting in the establishment of the

267 Pharmacologic inhibition of ERK and JAK/STAT pathways reversed miR-194-driven phenotypes.

268 rved molecular mechanism that directly links JAK/STAT pathway signalling to intercellular adhesion an

269 CDK8 kinase inhibition blocked activation of JAK-STAT pathway TFs.

270 vo, to identify ligands and mediators of the JAK-STAT pathway that accompany glial activation.

271 f IFN-alpha therapy are likely to act at the JAK-STAT pathway that controls transcription of downstre

272 aling 3 (Socs3), a feedback inhibitor of the Jak-Stat pathway that prevents Stat3 activation.

273 ne signaling-3 (SOCS3), 2 key factors of the JAK/STAT pathway that induce and inhibit STAT3 activatio

274 K)1/2, but not induction of apoptosis or the JAK/STAT pathway that is necessary for the antiviral eff

275 f immune responses, and dysregulation of the JAK/STAT pathway, that is, hyperactivation, has patholog

276 presses the activation of the astrogliogenic Jak-Stat pathway, the underlying molecular mechanism was

277 or mosquito vector for dengue virus uses the JAK-STAT pathway to control virus infection.

278 the production of Upd2, which activated the JAK-STAT pathway to promote ISC proliferation.

279 the expression of various components of the Jak-STAT pathway to strengthen STAT signaling and trigge

280 ontribution of the small interfering RNA and JAK-STAT pathways to the control of viral infections, we

281 find that the microRNA miR-279 regulates the JAK/STAT pathway to drive rest:activity rhythms in Droso

282 Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN-g

283 IL-12, IL-23, IFN-gamma, and GM-CSF, use the JAK/STAT pathway to induce biological responses.

284 a, in which RNA interference, NF-kappaB, and JAK-STAT pathways underlie antiviral immunity.

285 ediated through the diffusible ligand of the Jak/STAT pathway, Unpaired (Upd), which was recently ide

286 signaling factors for the WNT, TGF-beta, and JAK/STAT pathways use their intrinsically disordered reg

287 the therapeutic potential of inhibiting the JAK/STAT pathway using the JAK1/2 inhibitor, AZD1480.

288 concentrations of pegIFN-alpha in serum, the Jak/STAT pathway was activated in hepatocytes only on th

289 Activation of Ras and Jak/Stat pathways was enhanced in all HCCs when compared

290 l transducer and activator of transcription (Jak/Stat) pathway was discovered 20 years ago as a media

291 aling 3 (SOCS3), a protein suppressor of the JAK-STAT pathway, was constitutively highly expressed an

292 the dynamical behavior of the HER4 mediated JAK-STAT pathway which could be useful in designing trea

293 acts on interferon-stimulated genes via the JAK-STAT pathway, which has been implicated in developme

294 es 24p3 expression through activation of the JAK/STAT pathway, which culminates in binding of Stat5 t

295 entricles of adult rats did not activate the JAK/STAT pathway, which is potentially due to increased

296 Inhibition of the JAK/STAT pathway, which was expressed in both malignant

297 ale soma signals to the germline through the JAK/STAT pathway, while the nature of the signal from th

298 Blockade of the JAK-STAT pathway with a small molecule has been shown to

299 IL-7 activated the JAK/STAT pathway, with increased phosphorylation of JAK-

300 pothesis that using these drugs to block the JAK-STAT pathway would prevent autoimmune diabetes.