ライフサイエンスコーパス: Jagged2

1 components, including Notch1 , Notch2 , and Jagged2 .

2 asts expressing the Notch ligands Jagged1 or Jagged2.

3 JAG2 encodes the Notch ligand Jagged2.

4 Here we demonstrate that Jagged2, a Notch ligand, stimulates the development of n

5 Therefore, hypoxia-induced Jagged2 activation in both tumor invasive front and norm

6 EO database and found that the expression of Jagged2 among all five ligands is most significantly cor

7 We present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with

8 MAML1 and MAML2 amplified Notch ligand (both Jagged2 and Delta1)-induced transcription of the HES-1 g

9 also interacted with the other DSL ligands, Jagged2 and Delta1, they were not found associated with

10 61 clinical samples also revealed that both Jagged2 and Notch signaling were strongly upregulated at

11 However, Jagged2 and Notch1 are coexpressed in the apical ectoder

12 mmunohistochemistry revealed coexpression of Jagged2 and Notch1 within thymus and other fetal murine

13 ar level, we show that Fgf10 is epistatic to Jagged2 and Tgfbeta3 in the developing palate.

14 f MEE cells and for the normal expression of Jagged2 and Tgfbeta3 in the palatal epithelium during ma

15 ic progenitors and endothelial cells express Jagged2 and that exogenous, full-length Jagged2 promotes

16 ive NOTCH receptors (NOTCH1 and -2), ligand (JAGGED2), and target genes (HES1, HEY1, and HEY2) was ob

17 ulatory molecules, Notch ligands Jagged1 and Jagged2, and CD11b, and produced more Ifnb and Il23 but

18 Although low levels of Jagged1, Jagged2, and constitutive expression of Notch1 were seen

19 o injury, we analyzed expression of Jagged1, Jagged2, and Notch1 through 4 after balloon catheter den

20 bryonic day E14.5, when Notch1, Jagged1, and Jagged2 are expressed broadly in the papilla and general

21 , we demonstrate that like Notch, Delta1 and Jagged2 are subject to presenilin (PS)-dependent, intram

22 d Notch2, the Notch-ligand genes Jagged1 and Jagged2, as well as the Notch target gene Hes1.

23 ligands, Delta-like 1 (Dll-1), Jagged1, and Jagged2, as well as three transcription factors, Hes1, H

24 Supporting this hypothesis, we found that Jagged2 but not Jagged1 expression, correlates with the

25 othelial cells also expressed high levels of Jagged2, but stromal fibroblasts did not.

26 Activation of Jagged2 by hypoxia in tumor cells induced EMT and also p

27 e the case of APP, CTFs derived from Notch1, Jagged2, deleted in colorectal cancer (DCC), and N-cadhe

28 Moreover, retrovirally induced expression of Jagged2 did not enhance the ability of DCs to induce Th2

29 oping limb bud, it was possible that loss of Jagged2 disabled only part of Notch function in the limb

30 , as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ERalph

31 Signaling through Jagged2 expanded Treg cells and suppressed EAE when admi

32 Our data indicate that Jagged2 expression by DCs is not sufficient or required

33 Jagged2 expression is up-regulated in response to the he

34 he Notch pathway using soluble Notch ligand, Jagged2-Fc, induced IL-9 and IL-17A while delta-like 4Fc

35 sembled a full-length cDNA, now called human Jagged2, from overlapping cDNA clones.

36 entiation and that IRF6 and the Notch ligand Jagged2 function in convergent molecular pathways during

37 erin, Pdx1, Nkx6.1, Notch1, Notch2, Jagged1, Jagged2, Hes1), hereby describing the kinetics of tissue

38 elta and Serrate, human Jagged1 (HJ1), human Jagged2 (HJ2), and human Delta1 (H-Delta-1), and determi

39 tion was performed, expression of the murine Jagged2 homolog was found to be highest in fetal thymus,

40 f our immunohistochemical (IHC) analysis for Jagged2 in 61 clinical samples also revealed that both J

41 part, by targeting Notch ligand Jagged1 and Jagged2 in cancer cells and inducing Notch activation in

42 Furthermore, the expression of Jagged2 in P493-6 tumors often overlapped with regions o

43 is not clear from the expression pattern of Jagged2 in the apical ectodermal ridge (AER) whether the

44 Jagged2 induces the strongest Notch signal through inter

45 Antibody targeting of Jagged2 inhibited tumor growth and activated IRF4-driven

46 Furthermore, unlike Jagged1, Jagged2 is coexpressed with Notch in the developing thym

47 ole in tumor progression and metastasis, and Jagged2 is considered to be a valuable prognostic marker

48 Notably, the expression of Jagged2 is downregulated throughout the palate epitheliu

49 previously described DSL ligands for Notch, Jagged2 is not widely expressed in the developing centra

50 The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notc

51 We have examined the in vivo role of the Jagged2 (Jag2) gene, which encodes a ligand for the Notc

52 mozygous for a targeted null mutation of the Jagged2 (Jag2) gene, which encodes a Notch ligand, super

53 l cancer, bone marrow-derived CD11b(Itgam)(+)Jagged2 (Jag2)(+) cells infiltrated primary tumors and s

54 Exposure of C2C12 cells to Jagged2 led to increased amounts of Notch mRNA as well a

55 rimental autoimmune encephalomyelitis (EAE), Jagged2 ligation regulated clinical disease in an IL-9-d

56 Our results confirm that Jagged2 loss describes the contribution of the entire No

57 In contrast, Jagged2-mediated Notch activation primarily results in g

58 indings reveal what we believe to be a novel Jagged2/miR-200-dependent pathway that mediates lung ade

59 In silico analysis predicted that many Jagged2 missense variants are associated with structural

60 entified through this approach encodes mouse Jagged2 (mJagged2).

61 ligand Jagged1 was induced by hypoxia, while Jagged2 mRNA expression was highly sensitive to hypoxia

62 Twenty-two of these genes, including Fgfr2, Jagged2, Msx2, Satb2 and Tgfb3, have been previously imp

63 locking antibodies confirm the importance of Jagged2/Notch3 signaling in human TCR-gammadelta differe

64 ere, we studied the role of the Notch ligand Jagged2 on immune evasion in non-small cell lung cancer

65 Thus, Jagged2 orchestrates immunosuppressive systems in NSCLC

66 findings offer the proposal that Delta1 and Jagged2 play dual roles as activators of Notch receptor

67 and engineered mutations in the Notch ligand Jagged2 produced the Syndactylism phenotype.

68 and Notch ligands and that the Notch ligand Jagged2 promotes metastasis.

69 ress Jagged2 and that exogenous, full-length Jagged2 promotes the survival and proliferation of hemat

70 rgeted mutation that removes a domain of the Jagged2 protein required for receptor interaction.

71 are required in the ectoderm to receive the Jagged2 signal.

72 mal compartment of the limb bud receives the Jagged2 signal.

73 Our findings indicate that Jagged2 stimulates the development of natural killer cel

74 nes hairy and enhancer of split 4 (HES4) and JAGGED2, supporting the view that the neuronal epigenome

75 ntrol of these genes initiated by binding of Jagged2 to Notch1.

76 from tissues of 2-week-old mice, the 5.0-kb Jagged2 transcript was most abundant in heart, lung, thy

77 e correlations, suppression of expression of Jagged2 using retrovirally delivered small interfering R

78 Importantly, Jagged2 was also found to be upregulated in bone marrow

79 JAGGED2 was also overexpressed and associated with gene

80 Mechanistically, Jagged2 was found to promote metastasis by increasing th

81 s, JAG2 that encodes a Notch receptor ligand Jagged2, was directly induced by Myc.

82 k patients overexpressed Notch3, Notch4, and Jagged2 while displaying a reduction in expression level

83 We have isolated a novel Serrate-like gene, Jagged2, whose amino acid sequence and expression patter

84 Coculture of fibroblasts expressing human Jagged2 with murine C2C12 myoblasts inhibited myogenic d