ライフサイエンスコーパス: Jakob

1 In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase

2 actors in response to the foreign Creutzfeld-Jakob disease agent, it is likely that innate immunity u

3 on of the attenuated SY strain of Creutzfeld-Jakob disease in mice could delay clinical signs and wid

4 studying transmission of variant Creutzfeld-Jakob disease by blood products in humans.

5 The emergence of variant Creutzfeld-Jakob disease, following on from the bovine spongiform e

6 to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about the zoonotic p

7 Creutzfeldt-Jakob disease (CJD) and autoimmune encephalitis with ant

8 Creutzfeldt-Jakob disease (CJD) has been accidentally transmitted by

9 Creutzfeldt-Jakob disease (CJD) in humans has been shown to be trans

10 Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disorder caus

11 Creutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neuro

12 Creutzfeldt-Jakob disease (CJD) is a rare progressive neurodegenerat

13 Creutzfeldt-Jakob disease (CJD), the most common human prion disease

14 were Alzheimer's disease (18%), Creutzfeldt-Jakob disease (12%) and inflammatory disorders (9%).

15 al sclerosis (FTD/ALS, n = 252), Creutzfeldt-Jakob disease (CJD, n = 239), Parkinson's disease (PD, n

16 neity, including patients with a Creutzfeldt-Jakob disease (CJD) phenotype.

17 disease with this feature after Creutzfeldt-Jakob disease, originally reported in 1920.

18 hallenge with the human kuru and Creutzfeldt-Jakob agents as well as with scrapie agent isolated from

19 ms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atyp

20 (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans.

21 e spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans.

22 eases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targ

23 as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic mechanism invo

24 esthesia, pure dementia GSS, and Creutzfeldt-Jakob disease-like GSS); GSS may be more common than pre

25 hrogenic diabetes insipidus, and Creutzfeldt-Jakob disease.

26 isease, motor neuron disease and Creutzfeldt-Jakob disease.

27 tions, including Alzheimer's and Creutzfeldt-Jakob diseases and type II diabetes.

28 ng Alzheimer's, Parkinson's, and Creutzfeldt-Jakob diseases.

29 s, ataxia, dystonia, chorea, and Creutzfeldt-Jakob with and Jewish.

30 ementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system disease

31 thy (BSE; "mad cow" disease) and Creutzfeldt-Jakob's disease, appears to be a beta-sheet-rich amyloid

32 zheimer's (AD), Parkinson's, and Creutzfeldt-Jakob, and in animal diseases such as BSE.

33 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are fatal, neuro-degenerative disord

34 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidly fatal neur

35 ions were initially diagnosed as Creutzfeldt-Jakob disease (CJD).

36 urodegenerative diseases such as Creutzfeldt-Jakob disease (CJD).

37 o various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker syndrom

38 enesis of prion diseases such as Creutzfeldt-Jakob disease and scrapie.

39 Prion diseases such as Creutzfeldt-Jakob disease are possibly caused by the conversion of a

40 Human prion diseases such as Creutzfeldt-Jakob disease are transmissible brain proteinopathies, c

41 d both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular isoform (PrP

42 ction of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with superinfect

43 ents, dementia with Lewy bodies, Creutzfeldt-Jakob disease, vascular or unclassified dementia.

44 of the infectious agents causing Creutzfeldt-Jakob disease (CJD), scrapie, and bovine spongiform ence

45 stant to both kuru and classical Creutzfeldt-Jakob disease (CJD) prions (which are closely similar) b

46 o date, 1,147 cases of confirmed Creutzfeldt-Jakob disease deaths in the United Kingdom since 1990 ha

47 wo hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of treatment,

48 cedures were applied to diagnose Creutzfeldt-Jakob disease (CJD).

49 hings was accurate in diagnosing Creutzfeldt-Jakob disease and indicated substantial prion seeding ac

50 invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly progressive dem

51 ated with one of these diseases [Creutzfeldt-Jakob disease (CJD)] that was exactly analogous to a pre

52 n causes the rare human disorder Creutzfeldt-Jakob disease (CJD).

53 Familial Creutzfeldt-Jakob disease and cerebrotendinous xanthomatosis tend to

54 al familial insomnia or familial Creutzfeldt-Jakob disease, depending upon the presence of Met or Val

55 variant, sporadic, and familial Creutzfeldt-Jakob disease, in the presence of blood components.

56 pinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included

57 e shorter incubation periods for Creutzfeldt-Jakob disease (CJD) prions than mice expressing full-len

58 detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of

59 rains of patients suffering from Creutzfeldt-Jakob disease and related conditions, such as Gerstmann-

60 cal syndrome is so distinct from Creutzfeldt-Jakob disease, and biomarkers of the early stages of dis

61 olymorphism protects people from Creutzfeldt-Jakob disease, the Sup35p polymorphisms were selected to

62 poral lobar degeneration (FTLD), Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), Parkinson

63 ic GT cells infected with the FU Creutzfeldt-Jakob disease agent, but not parallel mock controls, dis

64 Human Creutzfeldt-Jakob disease (CJD) and similar neurodegenerative diseas

65 rently less susceptible to human Creutzfeldt-Jakob disease prions.

66 , including sheep scrapie, human Creutzfeldt-Jakob disease, and cervid chronic wasting disease.

67 dotoxemia, sepsis, or iatrogenic Creutzfeldt-Jakob disease (to date, 1,147 cases of confirmed Creutzf

68 e French epidemics of iatrogenic Creutzfeldt-Jakob disease after growth hormone (GH) treatment provid

69 ease and in a case of iatrogenic Creutzfeldt-Jakob disease associated with growth hormone therapy.

70 Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced g

71 Many cases of iatrogenic Creutzfeldt-Jakob disease have been caused by the use of biological

72 ts who have developed iatrogenic Creutzfeldt-Jakob disease in the UK since 2003.

73 hort of patients with iatrogenic Creutzfeldt-Jakob disease in the UK suggests that there was a point

74 incubation period of iatrogenic Creutzfeldt-Jakob disease is significantly different between all thr

75 ts who have developed iatrogenic Creutzfeldt-Jakob disease, 56 have been genotyped.

76 both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information rega

77 poradic, variant, and iatrogenic Creutzfeldt-Jakob disease; kuru; inherited prion disease; sheep scra

78 Importance: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorde

79 in (PrP) plays a central role in Creutzfeldt-Jakob Disease (CJD) and other transmissible spongiform e

80 xtracts demonstrated that PrP in Creutzfeldt-Jakob disease (CJD) brains is cleaved by a cellular prot

81 rts have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G > A mutation in

82 Previous studies in Creutzfeldt-Jakob disease (CJD) have shown that myeloid cells in the

83 (BSE) in cattle and PrP(CJD) in Creutzfeldt-Jakob disease (CJD) in humans.

84 athological diversity evident in Creutzfeldt-Jakob disease and whether different prion protein types

85 rions, such as those involved in Creutzfeldt-Jakob disease.

86 enerative diseases which include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform ence

87 enerative disorders that include Creutzfeldt-Jakob disease in humans, scrapie in sheep and goats, and

88 ommon in the T/BG group included Creutzfeldt-Jakob disease, arbovirus, and Mycobacterium tuberculosis

89 degenerative disorders including Creutzfeldt-Jakob disease (CJD) in humans, is the conversion of the

90 neurological diseases including Creutzfeldt-Jakob disease (CJD), but the aggregation mechanisms rema

91 ion disease in humans, including Creutzfeldt-Jakob disease (CJD).

92 ans and other animals, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.

93 egenerative conditions including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongifor

94 degenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in sheep and bovine spo

95 odegenerative diseases including Creutzfeldt-Jakob disease, motor neuron disease and Alzheimer's dise

96 sease, and 2 of 2 with inherited Creutzfeldt-Jakob disease) but were negative in 43 of 43 patients wi

97 mans), responsible for inherited Creutzfeldt-Jakob disease, finds that the mutation lowers metal ion

98 st common human prion disease is Creutzfeldt-Jakob disease (CJD).

99 ive disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker syndrome (

100 ort from the Australian National Creutzfeldt-Jakob Disease Registry concerns a 61-year-old British-bo

101 atients referred to the National Creutzfeldt-Jakob Disease Research & Surveillance Unit during the pe

102 Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the lay public

103 lthough surgical transmission of Creutzfeldt-Jakob disease (CJD) has been demonstrated, these iatroge

104 nd accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly distinguish

105 forms and molecular subtypes of Creutzfeldt-Jakob disease (CJD), we applied 3 different anti-PrP ant

106 The sporadic form of Creutzfeldt-Jakob disease (sCJD) has been classified on the basis of

107 ince developed a variant form of Creutzfeldt-Jakob disease (vCJD), also mostly in the United Kingdom,

108 prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases, requires p

109 ective in slowing propagation of Creutzfeldt-Jakob disease prions in transgenic mice.

110 s with the E200K genetic form of Creutzfeldt-Jakob Disease, 20 healthy carriers of this mutation that

111 involved in the pathogenesis of Creutzfeldt-Jakob Disease, and its anatomical connections are suffic

112 detected early in the course of Creutzfeldt-Jakob Disease, and years before symptomatic onset in mut

113 appearance of a variant form of Creutzfeldt-Jakob disease, which has been linked to consumption of p

114 ecognized phenotypic spectrum of Creutzfeldt-Jakob disease.

115 90 to 100) for the detection of Creutzfeldt-Jakob disease.

116 owed early diagnosis of probable Creutzfeldt-Jakob disease before the characteristic clinical picture

117 luding Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and Lou Gehrig's diseases, as well as the tauopat

118 uch as Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and others display remarkable phenotypic heteroge

119 gates extracted from 60 sporadic Creutzfeldt-Jakob disease (CJD) and 6 variant CJD brains.

120 brains of patients with sporadic Creutzfeldt-Jakob disease (CJD) bind to very low-density (VLDL) and

121 from a large number of sporadic Creutzfeldt-Jakob disease (CJD) cases.

122 Sporadic Creutzfeldt-Jakob disease (CJD) is the most prevalent manifestation

123 those in subjects with sporadic Creutzfeldt-Jakob disease (CJD), as well as CJD-affected subjects wh

124 n human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are formed spontane

125 n a pregnant woman with sporadic Creutzfeldt-Jakob disease (CJD).

126 d as either familial or sporadic Creutzfeldt-Jakob disease (CJD); there was no case of variant CJD.

127 are these with cases of sporadic Creutzfeldt-Jakob disease (n = 170) in the United Kingdom over the p

128 onfer susceptibility to sporadic Creutzfeldt-Jakob disease (rs1029273), all patients were homozygous

129 were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alter

130 l fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detection of surro

131 Sporadic Creutzfeldt-Jakob disease (sCJD) comprises several subtypes as defin

132 (sFI) and a subtype of sporadic Creutzfeldt-Jakob disease (sCJD) identified as sCJDMM2, which share

133 an prion disease cases, sporadic Creutzfeldt-Jakob disease (sCJD) is the prevalent human prion diseas

134 ntiated 94% of cases of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 from the sCJD MM2 phenotype, an

135 firmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype.

136 Sporadic Creutzfeldt-Jakob disease (sCJD) presents as a rapidly progressive d

137 Sc237 prions and human sporadic Creutzfeldt-Jakob disease (sCJD) prions.

138 ed study of a cohort of sporadic Creutzfeldt-Jakob disease (sCJD) VV1-2 type-mixed cases (valine homo

139 st common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive dementia.

140 st common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive dementia.

141 have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionine/valine pol

142 o patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(MM1) or sCJD

143 Human sporadic Creutzfeldt-Jakob disease (sCJD), endemic sheep scrapie, and epidemi

144 ies present in control, sporadic Creutzfeldt-Jakob disease (sCJD), or variant CJD (vCJD) brains.

145 issue of a patient with sporadic Creutzfeldt-Jakob Disease (sCJD), the most common form of human prio

146 ces in individuals with sporadic Creutzfeldt-Jakob disease (sCJD).

147 ions from patients with sporadic Creutzfeldt-Jakob disease (sCJD).

148 , the most common being sporadic Creutzfeldt-Jakob disease (sCJD).

149 ntigens misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD).

150 as been also claimed in sporadic Creutzfeldt-Jakob disease (sCJD).

151 levels in some cases of sporadic Creutzfeldt-Jakob disease and conversely, that the form of abnormal

152 alopathies (variant and sporadic Creutzfeldt-Jakob disease and genetic forms of prion disease), patie

153 f the major subtypes of sporadic Creutzfeldt-Jakob disease and in a case of iatrogenic Creutzfeldt-Ja

154 wenty-six patients with sporadic Creutzfeldt-Jakob disease and nine age- and gender-matched healthy c

155 th and patients without sporadic Creutzfeldt-Jakob disease and tested them using RT-QuIC, an ultrasen

156 ived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by immortalized

157 clinically mistaken for sporadic Creutzfeldt-Jakob disease because of a negative family history.

158 tein that characterizes sporadic Creutzfeldt-Jakob disease can be found in certain brain regions of c

159 udy the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control subjects and t

160 Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a challenge.

161 pithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients.

162 Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey

163 Sporadic Creutzfeldt-Jakob disease is the most common of the human prion dise

164 ts appearance can mimic sporadic Creutzfeldt-Jakob disease on MRI and should be considered a differen

165 o improved detection of sporadic Creutzfeldt-Jakob disease prions in human nasal brushings and chroni

166 ely, the data show that sporadic Creutzfeldt-Jakob disease PrP(Sc) is not a single conformational ent

167 Cases diagnosed as sporadic Creutzfeldt-Jakob disease with atypical neuropathology were also rev

168 an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the case for va

169 (15 of 15 with definite sporadic Creutzfeldt-Jakob disease, 13 of 14 with probable sporadic Creutzfel

170 13 of 14 with probable sporadic Creutzfeldt-Jakob disease, and 2 of 2 with inherited Creutzfeldt-Jak

171 amples from humans with sporadic Creutzfeldt-Jakob disease, as well as in rodents with experimental p

172 In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is present not

173 ALS, Alzheimer disease, sporadic Creutzfeldt-Jakob disease, Huntington disease-like syndrome, and oth

174 matter of patients with sporadic Creutzfeldt-Jakob disease, mainly in the left hemisphere, with a str

175 hin the white matter in sporadic Creutzfeldt-Jakob disease, suggesting possible primary involvement o

176 stological diagnosis of sporadic Creutzfeldt-Jakob disease.

177 on human prion disease, sporadic Creutzfeldt-Jakob disease.

178 e encephalopathies from sporadic Creutzfeldt-Jakob disease.

179 diagnostic criteria of sporadic Creutzfeldt-Jakob disease.

180 s that closely resemble sporadic Creutzfeldt-Jakob disease.

181 diagnostic criteria for sporadic Creutzfeldt-Jakob disease.

182 bled those of classical sporadic Creutzfeldt-Jakob disease.

183 een and within cases of sporadic Creutzfeldt-Jakob disease.

184 erited prion disease or sporadic Creutzfeldt-Jakob disease.

185 0% for the diagnosis of sporadic Creutzfeldt-Jakob disease.

186 ttern of involvement in sporadic Creutzfeldt-Jakob disease.

187 e total white matter in sporadic Creutzfeldt-Jakob disease.

188 sed in the diagnosis of sporadic Creutzfeldt-Jakob disease; however, the characteristic waveforms do

189 rimental, acquired, and sporadic Creutzfeldt-Jakob diseases.

190 y for PrP(TSE) after exposure to Creutzfeldt-Jakob disease brain homogenate.

191 h a mouse model of transmissible Creutzfeldt-Jakob disease (CJD), the ataxia of Tg(A116V) mice is mor

192 pathy (BSE) to humans as variant Creutzfeldt-Jakob disease (CJD) has affected over 100 individuals, a

193 Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused by dietary o

194 e from a small sample of variant Creutzfeldt-Jakob disease (CJD).

195 prions from humans with variant Creutzfeldt-Jakob disease (CJD); on second passage in Tg(BoPrP) mice

196 autopsy-proved cases of variant Creutzfeldt-Jakob disease (n = 59) and compare these with cases of s

197 rP(Sc) molecular type in variant Creutzfeldt-Jakob disease (termed type 2B), presumably resulting fro

198 Variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform encephalopath

199 rodegenerative condition variant Creutzfeldt-Jakob disease (vCJD) and, based on recent human prevalen

200 a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient sensitivity an

201 m, a deceased carrier of variant Creutzfeldt-Jakob disease (vCJD) can be followed up to quantify tran

202 of the rising number of variant Creutzfeldt-Jakob disease (vCJD) cases.

203 Variant Creutzfeldt-Jakob disease (vCJD) differs from other human prion dise

204 o-person transmission of variant Creutzfeldt-Jakob disease (vCJD) has occurred through blood transfus

205 Infections with variant Creutzfeldt-Jakob disease (vCJD) have almost exclusively occurred in

206 number of patients with variant Creutzfeldt-Jakob disease (vCJD) have been treated with intraventicu

207 rt a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died from a non-ne

208 to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protect

209 The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of non-leukored

210 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disord

211 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disord

212 Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion disease caus

213 Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly distinctive

214 clinical expression of, variant Creutzfeldt-Jakob disease (vCJD) is essential for future management

215 ns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible by blood tra

216 prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD (iCJD) n = 1

217 encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully maintained up

218 The transmission of variant Creutzfeldt-Jakob disease (vCJD) through blood transfusions has crea

219 Interindividual variant Creutzfeldt-Jakob disease (vCJD) transmission through blood and bloo

220 ern since the reports of variant Creutzfeldt-Jakob disease (vCJD) transmission through blood transfus

221 possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion has caused co

222 the risk of transmitting variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion have relied l

223 Variant Creutzfeldt-Jakob disease (vCJD), a novel form of human prion diseas

224 f patients affected with variant Creutzfeldt-Jakob disease (vCJD), a prion disease typically acquired

225 The onset of variant Creutzfeldt-Jakob disease (vCJD), and the unknown prevalence of infe

226 cribed in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bovine spongifo

227 orm encephalopathy (BSE)/variant Creutzfeldt-Jakob disease (vCJD), Nipah virus, several viral hemorrh

228 ons, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).

229 profile associated with variant Creutzfeldt-Jakob disease (vCJD).

230 cally silent carriers of variant Creutzfeldt-Jakob disease (vCJD).

231 vidual can propagate the variant Creutzfeldt-Jakob disease agent and that the infectious agent can be

232 at the properties of the variant Creutzfeldt-Jakob disease agent could change after transmission to t

233 ated transmission of the variant Creutzfeldt-Jakob disease agent.

234 umulates in the brain in variant Creutzfeldt-Jakob disease also contains a minority type 1 component.

235 -mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patients, also sug

236 odegenerative conditions variant Creutzfeldt-Jakob disease and Alzheimer's disease.

237 o subsequently developed variant Creutzfeldt-Jakob disease and an asymptomatic red cell transfusion r

238 e urine of patients with variant Creutzfeldt-Jakob disease and had the typical electrophoretic profil

239 ained from patients with variant Creutzfeldt-Jakob disease and in none of the 224 urine samples obtai

240 on of 10% (wt/vol) human variant Creutzfeldt-Jakob disease brain homogenate, with >3,800-fold binding

241 nsfusion-transmission of variant Creutzfeldt-Jakob disease by red cell preparations.

242 iew, the transmission of variant Creutzfeldt-Jakob disease by transfusion has been confirmed.

243 against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blood or red bl

244 Recent evidence that variant Creutzfeldt-Jakob disease can be transmitted by transfusion of red c

245 were followed-up in six variant Creutzfeldt-Jakob disease cases with 9.4 T high-resolution magnetiza

246 from a UK cohort of 171 variant Creutzfeldt-Jakob disease cases.

247 ained from patients with variant Creutzfeldt-Jakob disease contained minute quantities of PrP(Sc).

248 train characteristics of variant Creutzfeldt-Jakob disease had been modified by the host genotype, sp

249 The recent emergence of variant Creutzfeldt-Jakob disease has led to major public health concerns, a

250 The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a potentially la

251 Three cases of variant Creutzfeldt-Jakob disease have been identified following red cell tr

252 te and probable cases of variant Creutzfeldt-Jakob disease have been methionine homozygotes (MM).

253 4, a subclinical case of variant Creutzfeldt-Jakob disease in a PRNP 129 methionine/valine heterozygo

254 scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans.

255 dividuals diagnosed with variant Creutzfeldt-Jakob disease in the USA and Canada.

256 t numbers of subclinical variant Creutzfeldt-Jakob disease individuals in at least the United Kingdom

257 n, the identification of variant Creutzfeldt-Jakob disease infection in a PRNP 129 methionine/valine

258 idence of any death from variant Creutzfeldt-Jakob disease or from conditions that could be confused

259 ents for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduction would b

260 Evidence suggests that variant Creutzfeldt-Jakob disease prions circulate in body fluids from peopl

261 The variant Creutzfeldt-Jakob disease strain has to date been characterized only

262 hus we have demonstrated variant Creutzfeldt-Jakob disease strain properties are not affected by tran

263 found in all 21 cases of variant Creutzfeldt-Jakob disease tested, irrespective of brain region exami

264 results show PrP(Sc) in variant Creutzfeldt-Jakob disease to be remarkably stereotyped.

265 was also present in the variant Creutzfeldt-Jakob disease tonsil.

266 consistent with those of variant Creutzfeldt-Jakob disease transmitted to 129 methionine/methionine i

267 Transmission of variant Creutzfeldt-Jakob disease was observed from the MV blood recipient s

268 ypes was maintained when variant Creutzfeldt-Jakob disease was transmitted to wild-type mice and was

269 d animals, one of which (variant Creutzfeldt-Jakob disease) is known to be a zoonotic form of the cat

270 ncephalopathies, such as variant Creutzfeldt-Jakob disease, are believed to result from infectious fo

271 is a defining feature of variant Creutzfeldt-Jakob disease, but that the biochemical isoform of PrP(S

272 ient, who did not die of variant Creutzfeldt-Jakob disease, has been identified with prion protein de

273 transmission studies in variant Creutzfeldt-Jakob disease, including those on the spleen and brain o

274 red human prion disease, variant Creutzfeldt-Jakob disease, is thought to result from oral exposure t

275 In variant Creutzfeldt-Jakob disease, prion replication is thought to occur fir

276 e urine of patients with variant Creutzfeldt-Jakob disease, we used the protein misfolding cyclic amp

277 f mid-2016, 231 cases of variant Creutzfeldt-Jakob disease-the human form of a prion disease of cattl

278 humans were diagnosed as variant Creutzfeldt-Jakob disease.

279 to-human transmission of variant Creutzfeldt-Jakob disease.

280 sporadic, iatrogenic and variant Creutzfeldt-Jakob disease.

281 ote to both sporadic and variant Creutzfeldt-Jakob disease.

282 ired, as is the case for variant Creutzfeldt-Jakob disease.

283 series of nine cases of variant Creutzfeldt-Jakob disease.

284 respiratory syndrome, or variant Creutzfeldt-Jakob disease.

285 (BSE) prions causes new variant Creutzfeldt-Jakob disease.

286 rus, enterovirus 70, and variant Creutzfeldt-Jakob disease.

287 more virulent strain of variant Creutzfeldt-Jakob disease.

288 ations are applicable to variant Creutzfeldt-Jakob in humans then a method for rendering human red ce

289 probable transmission of variant Creutzfeldt-Jakob infectivity by transfusion of red cell preparation

290 anding of the risks of (variant) Creutzfeldt-Jakob disease transmission via dental practice, and whet

291 successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, variant, and iat

292 sitive in 30 of 31 patients with Creutzfeldt-Jakob disease (15 of 15 with definite sporadic Creutzfel

293 with Parkinson's disease, 6 with Creutzfeldt-Jakob disease (CJD)).

294 erks develop in individuals with Creutzfeldt-Jakob disease (CJD), an incurable brain disorder caused

295 en exposed to medium spiked with Creutzfeldt-Jakob disease brain homogenate, resulting in a coarse gr

296 mone derived from a patient with Creutzfeldt-Jakob disease expressing prion protein valine 129.

297 NS) in five of six patients with Creutzfeldt-Jakob disease.

298 ive in 43 of 43 patients without Creutzfeldt-Jakob disease, indicating a sensitivity of 97% (95% conf

299 traussler syndrome and hereditary Creuzfeldt-Jakob disease, tau mutations cause autosomal dominant fr

300 was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.