ライフサイエンスコーパス: K. pneumoniae

1 K. pneumoniae 51-5 was isolated from stool of a healthy,

2 K. pneumoniae can evade serum killing and phagocytosis p

3 K. pneumoniae has become an increasing concern due to th

4 K. pneumoniae infection of STAT6 knockout mice resulted

5 K. pneumoniae is ubiquitous in the environment and can c

6 K. pneumoniae was recovered from 8/16 (50%) at all conce

7 K. pneumoniae were confirmed to belong to the same clone

8 K. pneumoniae-induced neutrophil ROS response required t

9 ormed with an arrayed library of over 13,000 K. pneumoniae transposon insertion mutants in the lungs

10 to simultaneously track the abundances of 10 K. pneumoniae strains in a murine pneumonia model.

11 n clinical data sets of 3436 S. aureus, 1362 K. pneumoniae and 348 E. faecium samples, ROC curves dem

12 sue, we studied a carbapenem-resistant ST-15 K. pneumoniae isolate (Kp3380) that displayed a remarkab

13 Of the 15 K. pneumoniae strains detected in the study, four were d

14 Between 2006 and 2012, K. pneumoniae showed epidemiological cycles of multi-dru

15 A total of 3846 K. pneumoniae cultures were identified, with an overall

16 d recovery from infection with each of the 5 K. pneumoniae strains, revealing a contribution of these

17 sequences and epidemiological data of >1,700 K. pneumoniae samples isolated from patients in 244 hosp

18 A K. pneumoniae sequence type 716 clone was identified as

19 that sapA is required for the adherence of a K. pneumoniae blood isolate to intestinal epithelial, lu

20 with abscesses caused by community-acquired K. pneumoniae in the kidneys and spleen without liver in

21 neutrophil recruitment in response to acute K. pneumoniae infection and thereby increases the lung K

22 resistance to bacterial dissemination, after K. pneumoniae infection or cecal ligation and puncture s

23 CRAMP exerted bactericidal activity against K. pneumoniae in vitro.

24 howed potent bacteriostatic activity against K. pneumoniae, which was dependent on lipocalin 2 (LCN2)

25 ch to identify protective antibodies against K. pneumoniae Several monoclonal antibodies were isolate

26 ctive role of Mincle in host defense against K. pneumoniae pneumonia by coordinating bacterial cleara

27 CCL8 in lung antibacterial immunity against K. pneumoniae and suggest new mechanisms of orchestratin

28 hils and in regulating host immunity against K. pneumoniae infection.

29 how commensal Bacteroidetes protect against K. pneumoniae colonization and contagion, providing insi

30 n, SKAP2, is required for protection against K. pneumoniae (ATCC 43816) pulmonary infections.

31 nd SP-B(N) conferred more protection against K. pneumoniae infection than each protein individually.

32 nge conferred significant protection against K. pneumoniae infection.

33 o confer population-level protection against K. pneumoniae infection.

34 bacteriovorus acting therapeutically against K. pneumoniae in serum, informing future research into t

35 ent in spectra from retrospectively analyzed K. pneumoniae outbreak isolates, concordant with results

36 g Bactec bottles for E. coli (P = 0.026) and K. pneumoniae (P <= 0.001).

37 y due to Acinetobacter baumannii (47.1%) and K. pneumoniae (35.3%).

38 most common pathogens were GAS (n = 16) and K. pneumoniae (n = 15).

39 d hospitalized adults with liver abscess and K. pneumoniae isolated from blood or abscess fluid who h

40 The CFU of recoverable P. aeruginosa and K. pneumoniae isolates were decreased, but the biofilm b

41 s or decreasing the CFU of P. aeruginosa and K. pneumoniae within a biofilm.

42 us collection of 196 isolates of E. coli and K. pneumoniae (PRIMERS II) were examined.

43 an adversely affect detection of E. coli and K. pneumoniae in anaerobic blood culture bottles.

44 tamase (ESBL)-producing Escherichia coli and K. pneumoniae isolates using MinION allowed successful i

45 d sisomicin suppressed growth of E. coli and K. pneumoniae, with N1MS exhibiting superior activity ag

46 When smvA from Salmonella and K. pneumoniae are expressed in Escherichia coli, which l

47 rum amyloid A2 (SAA2) and that SAA2 had anti-K. pneumoniae bactericidal activity in vitro.

48 candidate target in the development of anti-K. pneumoniae drugs.

49 y of these infections difficult to treat, as K. pneumoniae has become multidrug resistant.

50 he resurgence of severe community-associated K. pneumoniae infections has led to increased recognitio

51 Analysis of the available K. pneumoniae genomes revealed that this pathogen's geno

52 ssential during infection with A. baumannii, K. pneumoniae and P. aeruginosa.

53 omparisons have revealed differences between K. pneumoniae strains, but the impact of genomic variabi

54 obacteria prime immunity through IL-17A, but K. pneumoniae overcomes these defences through encapsula

55 eceptor Mincle in pneumonic sepsis caused by K. pneumoniae.

56 th care environment, patient colonization by K. pneumoniae precedes infection, and transmission via c

57 ibility to acute intrapulmonary infection by K. pneumoniae, regardless of strain.

58 e displayed this activity against capsulated K. pneumoniae Unexpectedly, the active peptide showed no

59 We chose K. pneumoniae for our in vivo model, since K. pneumoniae

60 ive) were compared with those of the classic K. pneumoniae (cKP) isolates.

61 ed with hvKp strains compared with classical K. pneumoniae (cKp) strains, which require lethal doses

62 rains are an emerging variant of "classical" K. pneumoniae (cKP) that cause organ and life-threatenin

63 lecular mechanisms leading to PR in clinical K. pneumoniae isolates are remarkably heterogenous, even

64 e 43816 strain and 4 newly isolated clinical K. pneumoniae strains.

65 The clinical K. pneumoniae strains, including one carbapenem-resistan

66 for bacteria including E. faecalis, E. coli, K. pneumoniae and S. aureus.

67 colonization patterns on an early colonizer, K. pneumoniae.

68 ae to human clinical infections, we compared K. pneumoniae isolates from retail meat products and hum

69 These data confirm K. pneumoniae colonization is a significant risk factor

70 Of note, 25/26 cultures containing K. pneumoniae that were reported as not detected by the

71 In contrast, K. pneumoniae-infected Rag2(-/-)Il2rg(-/-) mice failed t

72 Over the past decade, K. pneumoniae has emerged as a major clinical and public

73 pal-, lppA-, and ompA-deficient K. pneumoniae strains were constructed using an unmarked

74 ges, and primary splenocytes, we demonstrate K. pneumoniae 51-5 upregulates expression of proinflamma

75 he epithelial-damaging effect of PSC-derived K. pneumoniae that was associated with bacterial translo

76 mans can become infected with many different K. pneumoniae strains that vary in genetic background, a

77 e specific than (18)F-FDG in differentiating K. pneumoniae lung infection from lung inflammation.

78 erum sensitivity and virulence of 3 distinct K. pneumoniae (hypermucoviscous K1, research K2, and car

79 During K. pneumoniae infection, we observed subtle differences

80 ed that retain activity against encapsulated K. pneumoniae, suggesting that this bacterial defense ca

81 Endogenous K. pneumoniae endophthalmitis (EKE) has a higher inciden

82 zation by vancomycin-resistant Enterococcus, K. pneumoniae, and E. coli.

83 so showed reduced bacterial burden following K. pneumoniae challenge.

84 erstand potential contributions of foodborne K. pneumoniae to human clinical infections, we compared

85 0% for all classes, both for E. coli and for K. pneumoniae.

86 nt signaling in neutrophils is essential for K. pneumoniae-activated ROS production and for promoting

87 we present a detailed genomic framework for K. pneumoniae based on whole-genome sequencing of more t

88 Further, for K. pneumoniae (KpI), the entity most frequently associat

89 ed in 88 patients with cultures positive for K. pneumoniae hospitalized in the Beijing You'an Hospita

90 Periodic patient screening for K. pneumoniae colonization has the potential to curb the

91 ng potential carbon and nitrogen sources for K. pneumoniae and of 99% in predicting nonessential gene

92 sults support MrkA as a promising target for K. pneumoniae antibody therapeutics and vaccines.

93 The conjugation frequency of OXA-48 from K. pneumoniae and E. coli in the gut of low-complexity-m

94 b OXA-48-containing IncL/M-type plasmid from K. pneumoniae to E. coli belonging to the novel ST666 in

95 Furthermore, K. pneumoniae 51-5 induces DNA damage and cell cycle arr

96 Furthermore, K. pneumoniae carrier mice were able to transmit to unin

97 ) were Klebsiella pneumoniae and 74 harbored K. pneumoniae carbapenemase (56.1%), 54 metallo-beta-lac

98 OXA-48-harboring K. pneumoniae isolates belonging to ST14 were isolated d

99 to K. pneumoniae infection in mice; however, K. pneumoniae-stimulated reactive oxygen species (ROS) p

100 A hypervirulent K. pneumoniae isolate was able to translocate from the G

101 lls, against the 2 predominant hypervirulent K. pneumoniae serotypes, K1 and K2.

102 cquired infections caused by 'hypervirulent' K. pneumoniae has also emerged, associated with strains

103 In K. pneumoniae resin-containing bottles, recovery was obs

104 sistance to a number of cationic biocides in K. pneumoniae and other members of the Enterobacteriacea

105 ive element that can co-occur with ICEKp1 in K. pneumoniae.

106 We identified ICEKp2 in K. pneumoniae sequence types ST11, ST258 and ST512, whic

107 concerns have stimulated renewed interest in K. pneumoniae research and particularly the application

108 Furthermore, fluoroquinolone-resistance in K. pneumoniae clinical isolates is reversed by expressio

109 Insertions in 166 genes resulted in K. pneumoniae mutants that were significantly less fit i

110 Lung infections in mice confirmed roles in K. pneumoniae virulence for the DeltadedA, DeltadsbC, De

111 nes citAB, are highly homologous to those in K. pneumoniae Deletion analysis shows that these cit gen

112 The majority of bla(KPC) genes were in K. pneumoniae isolates, which fell into 14 clonal groups

113 The epidemic curve of incident K. pneumoniae cases showed a bimodal distribution of cas

114 nction against invading pathogens, including K. pneumoniae.

115 findings demonstrate pathogenicity of infant K. pneumoniae isolate is sensitive to microbial coloniza

116 bacteriophage (NTUH-K2044-K1-1) that infects K. pneumoniae NTUH-K2044 (capsular type K1) was isolated

117 Interestingly, K. pneumoniae 51-5 induced tumors in Apc(Min/+); Il10(-/

118 ial cell characteristics in an international K. pneumoniae isolate collection (n = 48), with a range

119 ead to the emergence of untreatable invasive K. pneumoniae infections; our data provide the whole-gen

120 ambridge, United Kingdom, in 2015 to isolate K. pneumoniae from stool, blood, and the environment.

121 esenteric lymph nodes in these mice isolated K. pneumoniae, Proteus mirabilis and Enterococcus gallin

122 The isolated K. pneumoniae strains (n = 10) were of capsular polysacc

123 ass and reduced the CFU of E. coli isolates, K. pneumoniae isolates were observed to have a reduction

124 even among this small selection of isolates, K. pneumoniae adopts differing mechanisms and utilizes d

125 e used for the diagnosis and treatment of K1 K. pneumoniae infections.

126 s administered orogastrically in serotype K1 K. pneumoniae-colonized mice and the outcome was compare

127 We conducted phylogenetic analyses of key K. pneumoniae multi-locus sequence types (ST258, ST17, S

128 most common resistance mechanisms were KPC (K. pneumoniae carbapenemases) beta-lactamases encoded by

129 emergence and clinical impact of a novel KPC-K. pneumoniae ST16 clone in a Clonal Complex (CC)258 end

130 pneumoniae into three distinct species, KpI (K. pneumoniae), KpII (K. quasipneumoniae), and KpIII (K.

131 t the pathobiology and epidemicity of Kpi(+) K. pneumoniae and indicate that the presence of Kpi may

132 Analysis of a large K. pneumoniae population from 32 European countries show

133 in the upper airways and intestine to limit K. pneumoniae colonization within these niches.

134 lly, we demonstrated that the decreased lung K. pneumoniae burden associated with allergic airway inf

135 We showed that the decreased lung K. pneumoniae burden was independent of IL-4, IL-5, and

136 nflammation significantly decreased the lung K. pneumoniae burden and postinfection mortality.

137 iae infection and thereby increases the lung K. pneumoniae burden.

138 ae with DMG prior to injection of either MDR K. pneumoniae or MDR S. Typhimurium led to 40% and 60% s

139 E. coli lipid A, whereas only LpxL2 mediated K. pneumoniae lipid A acylation.

140 To identify novel K. pneumoniae virulence factors needed to cause pneumoni

141 ains were identified, responsible for 12% of K. pneumoniae infections in ICU.

142 Nearly 25% of K. pneumoniae clinical isolates in a US network of LTACH

143 In sum, 49% of K. pneumoniae infections were caused by the patients' ow

144 or for infection in ICU, and indicate 50% of K. pneumoniae infections result from patients' own micro

145 Overall, 33.0% (29/88) of K. pneumoniae isolates were hvKP.

146 Kpi contributes positively to the ability of K. pneumoniae to form biofilms and adhere to different h

147 e screened for rectal and throat carriage of K. pneumoniae shortly after admission.

148 In contrast to cases of K. pneumoniae bacteremia with primary liver abscesses in

149 Challenge of K. pneumoniae with chlorhexidine and another cationic bi

150 Optimal clearance of K. pneumoniae from the host lung requires TNF and IL-17A

151 While pulmonary clearance of K. pneumoniae is preserved in neutrophil-depleted mice,

152 ophils and CCR2(+) monocytes to clearance of K. pneumoniae pulmonary infection.

153 ter microbiota depletion, early clearance of K. pneumoniae was impaired, and this could be rescued by

154 in an epidemic multidrug-resistant clone of K. pneumoniae (ST258).

155 uggest that MrkD1P allows for competition of K. pneumoniae with P. aeruginosa in a mixed-species biof

156 ified self ligands, is a host determinant of K. pneumoniae pathogenicity.

157 vides new insights into host determinants of K. pneumoniae pathogenicity and raises the possibility t

158 gate the evolution and spatial dispersion of K. pneumoniae in support of hospital infection control.

159 ounts, as well as increased dissemination of K. pneumoniae to blood and liver, compared with control-

160 role in the pathobiology and epidemicity of K. pneumoniae is therefore important for managing infect

161 ystems in 259 clinically relevant genomes of K. pneumoniae.

162 insights into the pathogenic interaction of K. pneumoniae with the host gastrointestinal tract to ca

163 potential, and host-pathogen interactions of K. pneumoniae.

164 observed reduced phagocytosis and killing of K. pneumoniae in AMs from l/l mice that was associated w

165 However, knowledge of K. pneumoniae ecology, population structure or pathogeni

166 ocytes are rapidly recruited to the lungs of K. pneumoniae-infected mice and produce TNF, which marke

167 sion of MGL1 was upregulated in the lungs of K. pneumoniae-infected mice, and the deficiency of this

168 ed an increased influx in pneumonic lungs of K. pneumoniae-infected mice.

169 selective alternatives for the management of K. pneumoniae pneumonia.

170 In vitro screens using a minilibrary of K. pneumoniae transposon mutants identified putative fun

171 airway inflammation decreased the number of K. pneumoniae-induced airway neutrophils and lung IL-17A

172 icillin/ampicillin may lead to overgrowth of K. pneumoniae in the intestine and predispose to KPLA.

173 determinants suggests that the propensity of K. pneumoniae to spread in hospital environments correla

174 y and constitute an increasing proportion of K. pneumoniae strains, indicating an increasing propensi

175 like receptor (TLR)-dependent recognition of K. pneumoniae.

176 While there are more than 80 serotypes of K. pneumoniae, the K1 and K2 serotypes cause the vast ma

177 e of the hospital environment as a source of K. pneumoniae associated with serious human infection.

178 and no evidence for livestock as a source of K. pneumoniae infecting humans.

179 We evaluate putative sources of K. pneumoniae that are carried by and infect hospital pa

180 ide genome-wide support for the splitting of K. pneumoniae into three distinct species, KpI (K. pneum

181 imately, we find that host-to-host spread of K. pneumoniae occurs principally from its intestinal res

182 have used the rodent-adapted 43816 strain of K. pneumoniae and demonstrated that neutrophils are esse

183 model for KPPR1, a highly virulent strain of K. pneumoniae.

184 ur findings indicate that certain strains of K. pneumoniae have the ability to outcompete others in t

185 e is known about the population structure of K. pneumoniae, so it is difficult to recognize or unders

186 We conducted cross-sectional surveys of K. pneumoniae from 29 livestock farms, 97 meat products,

187 , shedding within feces, and transmission of K. pneumoniae through the fecal-oral route.

188 could inform new approaches to treatment of K. pneumoniae infections.

189 In vivo, we found that treatment of K. pneumoniae-infected mice with SP-A and SP-B(N) confer

190 A deeper understanding of K. pneumoniae population structure and diversity will be

191 pproaches have advanced our understanding of K. pneumoniae taxonomy, ecology and evolution as well as

192 gulatory gene fimK promotes the virulence of K. pneumoniae strain TOP52 in murine pneumonia.

193 terized the effects of these two peptides on K. pneumoniae, along with their physical interactions wi

194 ene in genomic DNA extracted from E. coli or K. pneumoniae clinical isolates within a few minutes.

195 o patients had highly related mcr-1-positive K. pneumoniae isolated from clinical cultures; a duodeno

196 We included 88 patients with PR K. pneumoniae from 2011-2018 and collected demographic,

197 Ampicillin administration predisposed K. pneumoniae-colonized mice to increased bacterial burd

198 t Klebsiella pneumoniae strains that produce K. pneumoniae carbapenemase (KPC) have spread globally i

199 mong all CR-KP isolates, 73.2% (52) produced K. pneumoniae carbapenemases-2 (KPC-2).

200 erapy reduced lung counts of NDM-1-producing K. pneumoniae in a murine pulmonary challenge model.

201 We found that exposure of NDM-1-producing K. pneumoniae to AVI led to striking bactericidal intera

202 AVI sensitizes NDM-1-producing K. pneumoniae to innate immune clearance in ways that ar

203 ver, AVI markedly sensitized NDM-1-producing K. pneumoniae to killing by freshly isolated human neutr

204 nts were identified carrying NDM-1-producing K. pneumoniae, all of them epidemiologically linked with

205 lebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) sequence type (ST) 16 clone in a

206 lebsiella pneumoniae carbapenemase-producing K. pneumoniae followed a similar path some 20 years late

207 Carbapenemase-producing K. pneumoniae have become a global priority, not least i

208 lebsiella pneumoniae carbapenemase-producing K. pneumoniae infectious episodes in 22 polytrauma inten

209 d results for OXA-48 carbapenemase-producing K. pneumoniae strains (4 mug mL(-1)).

210 lebsiella pneumoniae carbapenemase-producing K. pneumoniae; and present strategies used to halt the s

211 ded-spectrum beta-lactamase (ESBL)-producing K. pneumoniae collected from patients resident in a regi

212 69/638 isolates) and 67.7% of ESBL-producing K. pneumoniae isolates (155/229 isolates).

213 lla pneumoniae carbapenemase (KPC)-producing K. pneumoniae were studied.

214 ce then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and hav

215 cases of infections caused by KPC-producing K. pneumoniae (KPC-Kp) in adults who received CAZ-AVI in

216 e, the international spread of KPC-producing K. pneumoniae is primarily associated with a single mult

217 nt progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of

218 outbreak of colistin-resistant KPC-producing K. pneumoniae.

219 Delhi metallo-beta-lactamase (NDM)-producing K. pneumoniae that occurred in 2 Belgian hospitals situa

220 We characterized 74 NDM-producing K. pneumoniae isolates (9 from hospital A, 24 from hospi

221 B on the same day as the first NDM-producing K. pneumoniae-positive patient from hospital B.

222 hat these genes encode proteins that protect K. pneumoniae against neutrophil-related effector functi

223 -generation cephalosporin-resistant (Ceph-R) K. pneumoniae, and susceptible K. pneumoniae isolates ca

224 bacteria were unable to significantly reduce K. pneumoniae burden in the blood or prevent disseminati

225 FSTL-1 Hypo mice had reduced K. pneumoniae lung burden compared with that of WT contr

226 transmitting virulent, antibiotic-resistant K. pneumoniae from food animals to humans.

227 Carbapenem-resistant K. pneumoniae (CR-KP) posts significant public health ch

228 describe an outbreak of carbapenem-resistant K. pneumoniae containing the blaOXA-232 gene transmitted

229 atients with blaOXA-232 carbapenem-resistant K. pneumoniae infections were identified at a tertiary c

230 atients with blaOxa-232 carbapenem-resistant K. pneumoniae isolates, including 9 with infections, 7 a

231 e to infection with the carbapenem-resistant K. pneumoniae ST258 strain.

232 ion of pathogenicity in carbapenem-resistant K. pneumoniae, resulting in the repeated convergence of

233 mic third-generation cephalosporin-resistant K. pneumoniae.

234 bruary 2013, twenty-one multi-drug resistant K. pneumoniae strains, were collected from patients hosp

235 erapeutic strategy even for highly resistant K. pneumoniae infections, and underscore the effect humo

236 eat infections caused by multidrug resistant K. pneumoniae.

237 most prevalent cause of multidrug-resistant K. pneumoniae infections in the United States and other

238 evolutionary changes in multidrug-resistant K. pneumoniae, demonstrating the highly recombinant natu

239 t resistance in four diverse serum-resistant K. pneumoniae strains (NTUH-K2044, B5055, ATCC 43816, an

240 Regulation of microbiota assembly revealed K. pneumoniae 51-5 accelerates onset of inflammation in

241 strong antimicrobial activity toward several K. pneumoniae strains from a previously inactive peptide

242 We show K. pneumoniae has a large accessory genome approaching 3

243 of respiratory and fecal specimens, showing K. pneumoniae species and clonal group identification an

244 e K. pneumoniae for our in vivo model, since K. pneumoniae increases IL-17A expression and gammadelta

245 Meat-source K. pneumoniae isolates were more likely than clinical is

246 gion has contributed to the success of ST258 K. pneumoniae.

247 e hypothesis that carbapenem-resistant ST258 K. pneumoniae is a single genetic clone that has dissemi

248 genome of these isolates revealed that ST258 K. pneumoniae organisms are two distinct genetic clades.

249 y providing an alternative tool for studying K. pneumoniae pathogenesis and control within the lung.

250 tant (Ceph-R) K. pneumoniae, and susceptible K. pneumoniae isolates causing bloodstream infections at

251 Interestingly, a carbapenem-susceptible K. pneumoniae ST278 (KpN06) was obtained 1 month later f

252 e liver and spleen and were more susceptible K. pneumoniae-induced sepsis.

253 Systemic K. pneumoniae infections may be preceded by gastrointest

254 m for disrupting the protective barrier that K. pneumoniae uses to avoid the immune system and last-r

255 We demonstrate that K. pneumoniae can enhance its pathogenicity by adopting

256 ta of patients with PSC and demonstrate that K. pneumoniae disrupts the epithelial barrier to initiat

257 Our findings indicate that K. pneumoniae Pal and LppA proteins are important in the

258 rt alerts clinicians to the possibility that K. pneumoniae bacteremia combined with multiple abscesse

259 Our results revealed that K. pneumoniae capsule polysaccharide (CPS) was necessary

260 a marker for GI colonization, we showed that K. pneumoniae can asymptomatically colonize the GI tract

261 Recently our group has shown that K. pneumoniae dampens the activation of inflammatory res

262 It has been shown that K. pneumoniae infections are characterized by reduced ea

263 Epidemiological studies suggest that K. pneumoniae host-to-host transmission requires close c

264 The time-scaled phylogeny suggested that K. pneumoniae strains isolated during the study period m

265 The K. pneumoniae bioconjugates are immunogenic and efficaci

266 Klebsiella pneumoniae isolates harboring the K. pneumoniae carbapenemase gene (bla(KPC)) are creating

267 The loss of SKAP2 significantly hindered the K. pneumoniae-induced phosphorylation of SFKs, Syk, and

268 f mobile elements shows that the flux in the K. pneumoniae population was linked to the introduction

269 de aggregation, leading to disruption of the K. pneumoniae capsule.

270 tance plasmids, particularly variants of the K. pneumoniae carbapenemase.

271 Mutants of the K. pneumoniae strain IA565 lacking the plasmid-borne mrk

272 Here, we report that the K. pneumoniae Sap (sensitivity to antimicrobial peptides

273 Phylogenetic analysis showed that the K. pneumoniae ST278 from patient 2 was likely a descenda

274 ctors of 30-day mortality rates, whereas the K. pneumoniae susceptibility phenotype was not.

275 ver, whether CCR2(+) monocytes contribute to K. pneumoniae clearance from the lung.

276 naling in hematopoietic cells contributes to K. pneumoniae-induced lung inflammation.

277 ations in CD36 may predispose individuals to K. pneumoniae syndromes.

278 rophils degranulated normally in response to K. pneumoniae infection in mice; however, K. pneumoniae-

279 ate that CD36 enhances LPS responsiveness to K. pneumoniae to increase downstream cytokine production

280 cating that the phenomenon was not unique to K. pneumoniae When KPPR1 was removed from the inoculum,

281 In the latter case, drug-tolerant K. pneumoniae can persist to yield potentially untreatab

282 ibution of host and bacterial factors toward K. pneumoniae dissemination.

283 tibiotic activity over AZ1 against wild-type K. pneumoniae, and coadministration with outer membrane

284 the weak inflammatory response of untreated K. pneumoniae-infected mice.

285 Finally, while the widely used K. pneumoniae model strain 43816 produces rapid dissemin

286 ith E. coli, 2/3 with K. oxytoca, 16/17 with K. pneumoniae, and 0/1 with Proteus spp.

287 and protection from pulmonary challenge with K. pneumoniae.

288 Intestinal colonization with K. pneumoniae, Proteus mirabilis, or Enterobacter cloaca

289 th wild-type neutrophils when incubated with K. pneumoniae.

290 g and improved survival after infection with K. pneumoniae compared with wild-type controls, an effec

291 ncreases in susceptibility to infection with K. pneumoniae or E. coli.

292 l depletion markedly worsened infection with K. pneumoniae strain 43816 and three clinical isolates b

293 /-) mice undergoing pulmonary infection with K. pneumoniae was compared.

294 ificantly more susceptible to infection with K. pneumoniae, confirming the likely in vivo relevance o

295 type mice after intratracheal infection with K. pneumoniae.

296 challenge prior to acute lung infection with K. pneumoniae.

297 along with their physical interactions with K. pneumoniae capsule.

298 hat, during pulmonary infection of mice with K. pneumoniae, conventional NK cells are required for op

299 els of IL-22 in the lungs postinfection with K. pneumoniae.

300 xtensively drug resistant (XDR) E. coli, XDR K. pneumoniae, and MDR A. baumannii were associated with