ライフサイエンスコーパス: KO

1 gous for either CR1(long), CR1(short) or CR1(KO).

2 the observed metabolic phenotype of EC-AGO1-KO.

3 AK2 alone (-18%) or in combination with PAK1 KO (-12%) (P < 0.05).

4 es are applied to evaluate the reactivity of KO(2) in ambient air.

5 redox process of O(2)/potassium superoxide (KO(2)).

6 at regions that are hypomethylated in Dnmt3 KO 2i-MEFs.

7 innate lymphoid (Il2rg knockout mice [Il2rg (KO)]), adaptive immune (Rag1 knockout mice [Rag1 (KO)]),

8 increased serum transaminases compared with KO alone.

9 ion/synthesis enzymes in KO/KD compared with KO alone.

10 ences in disease between PIV-vaccinated Tbet KO and CD4 KO mice.

11 lysis demonstrated blood from platelet-COX-1-ko and global-COX-1-ko mice produced similar eicosanoid

12 ype switching, since both PIV-vaccinated B2m KO and MHC-II KO mice produced less Coxiella-specific Ig

13 Combining SE deletion and KO and wild-type alleles in a genotypic series, we deter

14 n mRNAs and mouse mRNAs from LARP4 knockout (KO) and control cells.

15 ipoma cell line 621-101, MITF knockout (MITF.KO) and MITF-A overexpressing (MITF.OE) cell lines were

16 Nephron-specific TrkC knockout (TrkC-KO) and nephron-specific TrkC-overexpressing (TrkC-OE) m

17 ATG16L1 knockout (KO) and NOD2 KO organoids did not benefit from the MDP-i

18 el in mice with (WT) or without Lgals2 (Gal2-KO) and showed that Gal2 deficiency ameliorated DSS-indu

19 skeletal muscle from global Zip14 knockout (KO) and wild-type mice (WT).

20 ( KO) ) or Toll-like receptor 4 (TLR4; TLR4( KO) ), and animals were fed an HFD or treated with lipop

21 ice with EC-AGO1 deletion (EC-AGO1-knockout [KO]) and their wild-type littermates to a fast food-mimi

22 r OS disc morphogenesis, we generated a Prcd-KO animal model using CRISPR/Cas9.

23 ate cancer cells in WT and apolipoprotein-AI KO (apoA1-KO) C57BL/6J mice revealed that WT hosts, cont

24 Using a conditional KO approach, we further demonstrate that Bax acts via th

25 were as many vesicles in lobule V of CB (1) -KO as in CB (1) -WT, but their distribution decreased dr

26 When testing the effects of inducible EphA4 KO at different timepoints in SOD1(G93A) mice, we found

27 ness compared to single KOs at POD15 and Ank KO at POD30.

28 aMKIIdeltaC transgenic in wild-type (TG), or KO background, and wild-type mice exposed to TAC.

29 ause of its active utilization by the aralar-KO brain and the likely involvement of neuronal NAA in p

30 The Mfsd7c-KO brain exhibited hypoxia and neuronal cell death.

31 At the cellular level, Opn3-KO brown adipocytes cultured in darkness had decreased g

32 esorption was significantly reduced in Casp1-KO but not in Nlrp3-KO mice.

33 Trp53(KO)/C-Myc(OE) mice developed liver tumors in 3-5 weeks;

34 o disrupt Trp53 and overexpress C-Myc (Trp53(KO)/C-Myc(OE) mice).

35 cells in WT and apolipoprotein-AI KO (apoA1-KO) C57BL/6J mice revealed that WT hosts, containing hig

36 ing and HF hearts, 4 mouse lines: wild-type, KO (CaMKIIdelta-knockout), CaMKIIdeltaC transgenic in wi

37 samples and an engineered CRISPR/Cas9 ABCA12 KO cell line.

38 The PPIP5K KO cells exhibited elevated levels of NUDT3 mRNA substra

39 TAZ-KO cells exhibited increased expression of the iron expo

40 Multiomics analysis in GSTO1 KO cells found a strong positive correlation with cell a

41 thermore, overexpression of PYCR1 in PINCH-1 KO cells restores proline synthesis and cell proliferati

42 y a drop in TET2 levels, yet the analysis of KO cells suggested that TET2 is responsible for most 5fC

43 5) The disappearance of some proteins in 2-KO cells took place despite up-regulation of their mRNAs

44 Moreover, Pi efflux from PPIP5K KO cells was rescued by restoration of InsP(8) levels th

45 The EGR 1 KO cells were then cultured and stimulated with VEGF A a

46 Consistently, reconstitution of LC3B-KO cells with the phospho-mimicking T50E variant inhibit

47 in the MITF.OE cells and reduced in the MITF.KO cells, and luciferase assays showed this was due to t

48 k2 at tyrosine 402 is decreased in NK92 CD56-KO cells, demonstrating a functional link between CD56 a

49 KR-K296R, the TAR RNA binding protein or PKR-KO cells, reduces RAN protein levels.

50 ists reacidify lysosomes in PSEN1 Knock out (KO) cells and fibroblasts from PSEN1 familial AD patient

51 reted proteins upregulated in Ocy454-Gsalpha(KO) cells compared to Ocy454-Gsalpha(cont) , whereas sem

52 of CM from Ocy454 Gsalpha(cont) and Gsalpha(KO) cells identified neuropilin-1 (Nrp-1) and granulin (

53 Lipidomic profiling reveals that SNX14 (KO) cells increase membrane lipid saturation following e

54 In line with this, SNX14 (KO) cells manifest delayed FA processing and lipotoxicit

55 knockdown of Nrp-1 and Grn in Ocy454-Gsalpha(KO) cells partially rescued the inhibition of osteoclast

56 Though KO CFs evoked larger amplitude EPSCs, the charge transfe

57 Mass spectrometry revealed that Nrf2-KO changed expression of 114 proteins while Keap1-KO cha

58 anged expression of 114 proteins while Keap1-KO changed expression of 117 proteins with 10 proteins i

59 d as the basal function of Nrf2, while Keap1 KO-changed proteins are involved in cellular detoxificat

60 Gene ontology analysis suggested that Nrf2 KO-changed proteins are involved in metabolism of oxidor

61 also reduced in double Hfe/endothelial Bmp2 KO compared with single endothelial Bmp2 KO female mice.

62 The PF terminals in lobule V of CB (1) -KO contained less synaptic vesicles and lower vesicle de

63 In this review, we discuss how CRISPR-KO/CRISPRa screening has contributed to our understandin

64 (KO) mice, reduced by 92% in Chk;Csk double KO (DKO) mice, and partially rescued in Chk;Csk;Ptprj tr

65 ), Enpp1 mutant (Enpp1(asj/asj)), and double KO (dKO) mice.

66 , we transplanted VAT from obese WT or NLRP3-KO donors into lean recipient mice.

67 4bp4(flox/flox) but not E4bp4 liver-specific KO (E4bp4-LKO) mice.

68 on defects were created in Ank knockout (Ank KO), Enpp1 mutant (Enpp1(asj/asj)), and double KO (dKO)

69 Together, the larger, faster EPSCs in the KO explain the altered complex spike responses, which de

70 e used a forebrain neuron-specific aromatase KO (FBN-ARO-KO) mouse model to deplete neuron-derived E2

71 mp2 KO compared with single endothelial Bmp2 KO female mice.

72 laque abundance was elevated in PS2APP;Trem2(ko) females at 6-7 months; but by 12 or 19-22 months of

73 rategies-definitive-null, targeted knockout (KO)-first, and CRISPR/Cas9.

74 pletion of mitochondrial CoQ within the Fmr1 KO forebrain closed the channel, blocked the pathologica

75 Interestingly, the phenotype of KO->WT and WT->KO mice did not differ from that of WT->W

76 ver CC1 null mutation augmented IRI-OLT (CC1-KO->WT) by enhancing ROS expression and HMGB1 translocat

77 ROS induction, and HMGB1 translocation (CC1-KO->WT), whereas ASK1 silencing (siRNA) promoted cytopro

78 ide (CyP) immunosuppressed or RAG2 knockout (KO) hamsters were exposed to severe acute respiratory sy

79 TTC7A-KO HAP1 cells have abnormal morphology and undergo apopt

80 of caspases 3 and 7 in TTC7A-knockout (TTC7A-KO) HAP1 (human haploid) cells and reduce the susceptibi

81 In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT)

82 e with liver-specific KO of Arrdc3 (L-Arrdc3 KO) have increased IR protein in plasma membrane.

83 Post-MI MAC-Mmp14 KO hearts contained fewer cells undergoing EndMT than th

84 lysine peptides measured in DKO versus Sirt3 KO hearts were strongly correlated.

85 l response to HuNoVs, we developed knockout (KO) HIE lines for IFN alpha and lambda receptors and the

86 significantly downregulated in the GFAP-ARO-KO hippocampus following GCI.

87 L-cholesterol, grew larger tumors than apoA1-KO hosts with lower levels of total and HDL-cholesterol.

88 ine models, we analyze ARID1A(WT) and ARID1A(KO) human endometrial epithelial cells.

89 marrow chimera mice demonstrated that STAT6 KO in either the CNS or periphery exacerbated ICH outcom

90 We found that EphA4 KO in young mice, but not older adult mice, causes defec

91 In mice, Ecm29 knockout (KO) in neurons increases the density of NKCC1 protein in

92 MNTB (and compensate for each other in each KO); in contrast, LSO neurons require Kv3.3 subunits for

93 ly inhibited cell proliferation, while SSTR1 KO induced cell proliferation, thus suggesting that HRH1

94 PRKD1(KO)-KC mice developed more pancreatic intraepithelial ne

95 Serum from PRKD1(KO)-KC mice had increased levels of sEVs compared with K

96 e total liver BA levels were similar between KO/KD and KO, there was significant dysregulation of BA

97 s and BA detoxification/synthesis enzymes in KO/KD compared with KO alone.

98 Although hepatocyte junctions were intact, KO/KD livers had significant canalicular defects, which

99 idated the presence of increased serum BA in KO/KD mice.

100 was higher in PIP2;5 OE and lower in pip2;5 KO lines compared with the corresponding wild-type plant

101 Complementation of the At2OGO-KO lines with a barley (cv. Conlon) orthologue, Hv2OGO,

102 2, 3, 4, and 5, were increased in the CGI-58 KO liver.

103 ly lowered chloride (Cl(-)) content in PSEN1 KO lysosomes.

104 te immune gene expression in Lrrk2 knockout (KO) macrophages is driven by a combination of mitochondr

105 loped more atherosclerotic lesions than Apoe KO male controls, regardless of diet (standard or WTD).

106 idal neurons in astrocyte-specific ephrin-B1 KO male mice, which coincided with a greater vGlut1/PSD9

107 beta4 knock-out (KO) male mice show increased novelty-induced locomotor a

108 Crosses between H2A.B KO males and females yield embryos with lower viability

109 Results showed that KO mice accumulated high concentrations of upstream lysi

110 ls are increased in FXR-knockout (KO) or SHP-KO mice and are decreased by activation of FXR in a SHP-

111 e, we report the characterizations of Mfsd7c-KO mice and compare these characterizations to phenotypi

112 obtained from striated muscle-specific Speg-KO mice and compared them with wild-type (WT) controls.

113 vealed a complete lack of testosterone in XY-KO mice and marked accumulation of progesterone in XX-KO

114 n was observed in colonoids derived from DRA-KO mice and short hairpin RNA-mediated DRA knockdown in

115 fibroblasts, and thymocytes from WT and MCU KO mice and the isolated working rat heart.

116 The KO mice and their matched wild-type mice were challenged

117 nges were remarkably reduced in Ins2 (Akita)/KO mice and, likewise, in vitro experiments with XBP1 si

118 lar bone formation between WT and Col6alpha2-KO mice based on the mineral appositional rate, bone for

119 terestingly, the phenotype of KO->WT and WT->KO mice did not differ from that of WT->WT mice.

120 ever, the gross levels of H3R17me2a in CARM1 KO mice did not significantly decrease, indicating that

121 Knockout (KO) of IL-6 in muscle lamin A/C-KO mice diminishes the deficits in trabecular bone mass

122 rebrain glutamatergic neuron-selective Ahnak KO mice display a depression-like behavioral phenotype s

123 At basal steady state Zip14 KO mice exhibited a phenotype that included muscle wasti

124 Eight-week-old double endothelial Bmp6/Bmp2 KO mice exhibited a similar degree of hepcidin deficienc

125 onstrated that ovariectomized female FBN-ARO-KO mice exhibited significantly attenuated astrocyte act

126 KO mice fed GC-1 diet for 2 and 4 weeks had decreased se

127 The KI/KO mice have a significant decrease in voluntary movemen

128 However, only the KI/KO mice have clear skeletal muscle histologic changes in

129 We first determined that global Kiss1r KO mice have significant alterations in body temperature

130 Skeletal muscle-targeted Lrrc8a KO mice have smaller myofibers, generate less force ex v

131 r of NGAL-deficient CD4(+) T cells from NGAL KO mice into CD4 KO or WT mice led to worse renal functi

132 We show that the auditory synapse of GLAST KO mice is more vulnerable to cisplatin administration d

133 KO mice lacked epileptic seizures when fed a low lysine/

134 investigated conditional/conventional double KO mice of BMP-receptor 1a (BMPR1a; targeted to PV-INs)

135 Here, we compared WT and GluA3 KO mice of both sexes and identified several important r

136 Constitutive Ahnak KO mice or forebrain glutamatergic neuron-selective Ahna

137 since both PIV-vaccinated B2m KO and MHC-II KO mice produced less Coxiella-specific IgG than PIV-vac

138 The heterozygous PME-1 KO mice produced normal levels of endogenous Abeta and e

139 lood from platelet-COX-1-ko and global-COX-1-ko mice produced similar eicosanoid profiles in vitro: f

140 Subcutaneous adipocytes in KO mice show a size distribution shift toward an increas

141 DG-GluN1 KO mice show CA3 cellular hyperactivity, detected using

142 Atherosclerotic plaques from HFD-treated KO mice showed increased infiltration of M1 type inflamm

143 vel multiple feature selection tools in Fmr1-KO mice to provide direct evidence that normal functioni

144 The enhanced resistance of Sema3E KO mice was associated with significantly (p < 0.05) inc

145 , the total chymotrypsinogen content in Ctrl-KO mice was barely reduced indicating that CTRL is a low

146 e response to skeletal muscle injury in Speg-KO mice was compared with that of WT mice, leading to th

147 AnxA1 and Fpr2/3 KO mice were highly susceptible to infection, displaying

148 The middle and the inner ears of WT and Nhe6 KO mice were not different morphologically.

149 tation of IP-mediated relaxation, iSM-Gprc5b-KO mice were protected from arterial hypertension, and t

150 Moreover, TRPV4 gene-KO mice were protected from Piezo1 agonist- and pressure

151 In the KO mice, expression of pERK was strongly reduced indicat

152 B signalling was disrupted in the OC of Nhe6 KO mice, probably due to TrkB reduction, caused by over

153 ed on the enhanced memory phenotype of Tiam1 KO mice, Tiam1 may be a potential target for the treatme

154 In USP30 KO mice, TOM subunits have reduced abundance across mult

155 In alpha2delta-1 gene KO mice, treatment with FK506 failed to increase the fre

156 mice, rats, and NHPs, but not in M(1) mAChR KO mice, VU0453595 produced dose-related increases in hi

157 flammation and cognitive impairment in NLRP3-KO mice, we transplanted VAT from obese WT or NLRP3-KO d

158 WT) B6 mice, the symptomatic corneas of CD1d KO mice, which lack iNKT cells, showed (i) decreases in

159 he subcutaneous and brown adipose tissues of KO mice, with greater vascularity and enhanced browning

160 ng PAK2 specifically in muscle, but not PAK1 KO mice.

161 t of LGMD2H pathology, are present in TRIM32 KO mice.

162 ated inflammatory programs in WT versus IRF3-KO mice.

163 albumin (PV) GABAergic interneurons of Ahnak KO mice.

164 icantly reduced in Casp1-KO but not in Nlrp3-KO mice.

165 pulmonary vaso-occlusions in End.TGFbetaRII-KO mice.

166 1, similar to was has been observed in TRPA1 KO mice.

167 These changes were not seen in MIOX-KO mice.

168 corresponding reduction in ethanol intake in KO mice.

169 and likely contribute to ataxia in Cacna2d2 KO mice.

170 creased in liver and skeletal muscle of CysC KO mice.

171 nd tissue iron overload compared with single KO mice.

172 lung tumorigenesis and metastasis in Gprc5a-ko mice.

173 e SE was nearly abolished in EP2 conditional KO mice.

174 nd marked accumulation of progesterone in XX-KO mice.

175 erone levels were observed in both XY and XX KO mice.

176 as absent in both platelet- and global-COX-1-ko mice.

177 enal IR was significantly attenuated in P2X4 KO mice.

178 ed in the cortices of betaOHB-treated aralar-KO mice.

179 nflammation, and oxidative stress in FBN-ARO-KO mice.

180 henotype similar to that of constitutive p11 KO mice.

181 cells, and an increase in apoptotic cells in KO mice.

182 rea parameters could be observed in GABA-CB1-KO mice.

183 ed to vigorous seizures and a quick death in KO mice.

184 sease between PIV-vaccinated Tbet KO and CD4 KO mice.

185 improved survival of high-lysine/low PN fed KO mice.

186 PS2APP;Trem2(ko) mice also exhibited more dendritic spine loss around

187 Notably, D1-cacna1c(KO) mice also show the same exaggerated remote contextua

188 We generated Rab39b knockout (KO) mice and found that they exhibited cortical neurogen

189 Bmp2 and Hfe compared with single knockout (KO) mice and littermate controls.

190 For that, AnxA1, Fpr2/3 knockout (KO) mice and wild-type (WT) controls were infected intra

191 Ghrelin knockout (KO) mice and wild-type (WT) littermates underwent an ins

192 Lung tumor suppressor gene Gprc5a-knockout (ko) mice are susceptible to lung inflammation, tumorigen

193 Cerebellum of Jdp2-knockout (KO) mice contains lower number of Atoh-1 positive GCPs t

194 ccinated WT mice to naive CD4-deficient (CD4 KO) mice demonstrated that antigen-experienced CD4(+) T

195 3 months of infection with H felis, Nlrc5(mo-KO) mice developed gastric hyperplasia (P < .0001), sple

196 In contrast, STAT6 knockout (KO) mice exhibited worse outcomes than WT mice in both I

197 ere delayed in only the PVPV-Akt1 knock out (KO) mice in association with increased apoptosis with no

198 Some intestinal crypts from Lkb1(Lgr5-KO) mice lost ISCs compared with crypts from control mic

199 cking either IL-12 or IFNgamma in Tnfaip3(Lg-KO) mice restored Th2 responses, whereas administration

200 d amyloid precursor protein (APP) knock-out (KO) mice to assess the effects of Abetaos on glutamaterg

201 We generated ZO-1 CM-specific knockout (KO) mice using alpha-Myosin Heavy Chain-nuclear Cre (ZO-

202 In this study, we found that IRF3-knockout (KO) mice were greatly protected from sepsis in a clinica

203 All Cyp17a1 knockout (KO) mice were phenotypically female; however, 58% were Y

204 his study, we found that Opn3-knockout (Opn3-KO) mice were prone to diet-induced obesity and insulin

205 Supporting this, P2X4-deficient (KO) mice were protected against ischemic AKI with signif

206 ice using Lgr5-regulated CRE-ERT2 (Lkb1(Lgr5-KO) mice) and the traced lineages by using a CRE-depende

207 rotein (Gsalpha) in osteocytes (Dmp1-Gsalpha(KO) mice) have abnormal myelopoiesis, osteopenia, and re

208 na1c from D1R-expressing neurons (D1-cacna1c(KO) mice).

209 gile X Mental Retardation 1 (Fmr1) knockout (KO) mice, a model of Fragile X Syndrome (FXS) with abrog

210 Platelet count was normal in Chk knockout (KO) mice, reduced by 92% in Chk;Csk double KO (DKO) mice

211 y diminished in female and male PS2APP;Trem2(ko) mice, respectively.

212 Utilizing Dock3 global knockout (Dock3 KO) mice, we found that the haploinsufficiency of Dock3

213 Using Tbet-deficient (Tbet KO) mice, we showed a partial role for Th1 subset CD4(+)

214 we suppressed beta-catenin in Mdr2 knockout (KO) mice, which develop sclerosing cholangitis due to re

215 with MAOIs in wild-type and TAAR1-knockout (KO) mice.

216 ed Na(v) availability in Fhf2 knockout (Fhf2(KO)) mice predisposes to abnormal excitability at the ti

217 FD feeding of CysC-deficient (CysC knockout [KO]) mice worsened obesity-associated adipose tissue inf

218 espiration due to futile proton leak in Fmr1 KO mitochondria caused by coenzyme Q (CoQ) deficiency an

219 ameliorates ER stress and fibrosis in Grp78 KO mouse and IPF lung slice cultures.Conclusions: These

220 ogenesis machinery, in mitochondria from TAZ-KO mouse cells and in CL-deleted yeast crd1Delta cells,

221 P1 with occludin and E-cadherin genes in DRA-KO mouse colon, suggesting that posttranscriptional mech

222 in tRNA were significantly decreased in Tet2 KO mouse embryonic stem cells (mESCs) in comparison with

223 Using a GluN2D KO mouse line (GluN2D(-/-)), we assessed behavioral phen

224 Importantly, in a Deptor-KO mouse model, Deptor knockout accelerated prostate tum

225 g a pan-brain-specific conditional knockout (KO) mouse incapable of FAO due to the loss of carnitine

226 ebrain neuron-specific aromatase KO (FBN-ARO-KO) mouse model to deplete neuron-derived E2 in the fore

227 y Kv3.2 or Kv3.4 in the respective knockout (KO) mouse.

228 Moreover, while PAK1 KO muscles displayed normal insulin-stimulated glucose u

229 PHD1(KO) muscles show impaired mTORC1 activation in response

230 The resulting At2OGO knock-out (KO) mutants display enhanced resistance to Fg in a detac

231 LRRC8A over-expression in Lrrc8a KO myotubes boosts PI3K-AKT-mTOR signaling to supra-norm

232 content, and function of lysosomes in PARK2 KO neurons and reveal an important new connection betwee

233 PARK2 KO neurons exhibited a perturbed lysosomal morphology wi

234 ort that betaOHB efficiently recovers aralar-KO neurons from deficits in basal-stimulated and glutama

235 duced in primary cultures of Ahnak knockout (KO) neurons compared to wild-type controls.

236 er Rab7, and higher Rab11 levels in the Nhe6 KO OC, compared to WT littermates.

237 while, conversely, mice with liver-specific KO of Arrdc3 (L-Arrdc3 KO) have increased IR protein in

238 KO of PPIP5Ks or XPR1 strongly reduced Pi efflux and acc

239 ynthetic" effect of the SJ1 mutation and the KO of Sac2 in mice.

240 KO of the endogenous TCR in T cells strongly ablated all

241 Here, we induced a CRISPR/Cas9-mediated KO of the TCRbeta chain in combination with a second-gen

242 Knockout (KO) of AHL4 enhanced, but overexpression (OE) of AHL4 at

243 CRISPR-based knockout (KO) of ATP2C1 decreases transduction by different AAV se

244 Kidney-specific knockout (KO) of Gpr116 caused a significant reduction in urine pH

245 Knockout (KO) of IL-6 in muscle lamin A/C-KO mice diminishes the d

246 Mice with a Purkinje-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) sho

247 Mice with liver-specific knockout (KO) of the insulin receptor (IR) have a 50% reduction in

248 uch cells to investigate the impact of PARK2 KO on the lysosomal compartment and found a clear link b

249 nt CD4(+) T cells from NGAL KO mice into CD4 KO or WT mice led to worse renal function than transfer

250 iR-802 levels are increased in FXR-knockout (KO) or SHP-KO mice and are decreased by activation of FX

251 hage/monocyte-specific deletion of YAP (YAP( KO) ) or Toll-like receptor 4 (TLR4; TLR4( KO) ), and an

252 Tissues from mice lacking ADTRP (Adtrp-KO), or both AIG1 and ADTRP (DKO) had higher concentrati

253 , adaptive immune (Rag1 knockout mice [Rag1 (KO)]), or both systems (Il2rg (KO)/Rag1 (KO)), were empl

254 ATG16L1 knockout (KO) and NOD2 KO organoids did not benefit from the MDP-induced cytopr

255 ss enhanced the glycolytic capacity in PINK1-KO-PBMCs but not in WT-PBMCs.

256 ave characterized recently generated Piccolo KO (Pclo(gt/gt) ) rats.

257 This novel BAT-Kiss1r KO phenotype was of greater magnitude in females and was

258 and restitution led to worsening of the Mdr2 KO phenotype, suggesting caution in targeting beta-caten

259 Consequently, EDA-KO pigs failed to eradicate a bacterial challenge in lun

260 EDA-KO pigs lacked SMGs throughout the airways.

261 rands disrupted mucociliary transport in EDA-KO pigs.

262 and heterodimeric BMP2/6 were blunted in Hfe KO primary hepatocytes.

263 t mice [Rag1 (KO)]), or both systems (Il2rg (KO)/Rag1 (KO)), were employed to investigate their respe

264 ) juveniles, the Il2rg (KO)/Tg(+) and Il2rg (KO)/Rag1 (KO)/Tg(+) juveniles exhibited suppressed expre

265 present a detailed phenotyping of the TRPA1 KO rat in models of pain, itch, and asthma that have pre

266 PA1 activation, we have found that the TRPA1 KO rat shows apparently normal behavioral responses in m

267 Our hope is that the TRPA1 KO rat will become a useful tool in further studies of T

268 Fmr1-KO rats exhibited reduced basal alpha power and enhanced

269 species and demonstrate the utility of Fmr1-KO rats for investigating drugs for the treatment of FXS

270 Fmr1-KO rats showed gamma power abnormalities and behavioral

271 examined Fmr1-targeted transgenic rats (Fmr1-KO rats) as an alternative preclinical model of FXS.

272 reduced at the gamma frequency band in Fmr1-KO rats.

273 ese 76 were differentially expressed in DJ-1 KO rats.

274 domain isoform 1 oxygen sensor in mice (PHD1(KO)) reduces muscle mass.

275 rast, vesicle density in lobule X of CB (1) -KO remained unchangeable relative to CB (1) -WT.

276 opy reveals that many disc membranes in Prcd-KO rod photoreceptor neurons are irregular, containing f

277 ncreased in CKD heart; DMTU treatment and UT-KO significantly abolished these increases.

278 DA SGK1 KO significantly decreased body weight of adult mice as

279 1 were knocked out by CRISPR, HRH1 knockout (KO) significantly inhibited cell proliferation, while SS

280 ng syngeneic SR-B1 WT (SR-B1(+/+)) and SR-B1 KO (SR-B1(-/-)) prostate cancer cells in WT and apolipop

281 that Rhbdf1 responds differently to distinct KO strategies, for example, by skipping exons and reinit

282 conformation was present in >97% of the KDO/KO structures in the Protein Data Bank.

283 of 3' alternative splicing events in fam50a KO, suggesting a role in the spliceosome C complex.

284 into BCs normalizes GABA release in the Fmr1-KO synapses.

285 +) and Rag1 (KO)/Tg(+) juveniles, the Il2rg (KO)/Tg(+) and Il2rg (KO)/Rag1 (KO)/Tg(+) juveniles exhib

286 s, the Il2rg (KO)/Tg(+) and Il2rg (KO)/Rag1 (KO)/Tg(+) juveniles exhibited suppressed expression leve

287 between the immunocompetent Tg(+) and Rag1 (KO)/Tg(+) juveniles, the Il2rg (KO)/Tg(+) and Il2rg (KO)

288 with IL-33(HET)/Tg+ mice, although the IL-33(KO)/Tg+ mice had significantly reduced levels of MUC5AC

289 ly in the distal intestine of VDR null mice (KO/TG mice) results in the normalization of serum calciu

290 ver BA levels were similar between KO/KD and KO, there was significant dysregulation of BA transporte

291 nd partially rescued in Chk;Csk;Ptprj triple KO (TKO) mice.

292 enerated a novel CTRL-deficient strain (Ctrl-KO) using CRISPR-Cas9 genome engineering.

293 e, tyramine accumulation was higher in TAAR1-KO versus wild-type mice, suggesting a negative feedback

294 lammatory/immune network was similar in IRF3-KO versus WT septic mice, although the tempo of connecti

295 verexpression (OE; B104 inbred) or knockout (KO; W22 inbred) lines.

296 the active zone in lobule V and X of CB (1) -KO was observed.

297 Hyperglucagonemia in alphaTSC2(KO) was associated with an increase in glucagon content

298 g1 (KO)]), or both systems (Il2rg (KO)/Rag1 (KO)), were employed to investigate their respective cont

299 nd disrupted the gene for ectodysplasin (EDA-KO), which initiates SMG development.

300 Cyp17a1 x Apoe double KO XY mice developed more atherosclerotic lesions than A