ライフサイエンスコーパス: Kr

1 Kr mutation affects the temporal fate of the neuroblast

2 Kr-h1 maintains the immature stage by suppressing E93 (e

3 the transcription factors Kruppel-homolog 1 (Kr-h1) and Broad-Complex (BR-C) during the last juvenile

4 Interestingly, Kruppel homolog 1 (Kr-h1) knockdown in the adult females did not reduce the

5 ncrease of mRNA levels of Kruppel homolog 1 (Kr-h1), a juvenile hormone-dependent transcription facto

6 he stage-specifying genes Kruppel homolog 1 (Kr-h1), broad and E93.

7 nger transcription factor Kruppel homolog 1 (Kr-h1), one of the key players in juvenile hormone signa

8 transcription factor (TF) Kruppel homolog 1 (Kr-h1).

9 sis showed high levels of Kruppel homolog 1 [Kr-h1, a transcription factor that plays key roles in ju

10 tized by the dominant Kr(irregular facets-1)(Kr(If-1)) allele, we show that the Piwi-interacting RNA

11 At present, ATTA (81)Kr analysis requires a 40-80-kg ice sample; as sample re

12 ample requirements continue to decrease, (81)Kr dating of ice cores is a future possibility.

13 Radiokrypton isotopes ((81)Kr and (85)Kr) are ideal tracers and chronometers of var

14 The analysis by using ATTA of (81)Kr in naturally occurring gases of interest, e.g., disso

15 We present successful (81)Kr-Kr radiometric dating of ancient polar ice.

16 We estimate the error in the (81)Kr ages due to past geomagnetic variability to be below

17 The (81)Kr radiometric ages agree with independent age estimates

18 bumin and simultaneous ventilation with (81m)Kr gas.

19 s in hyperpolarized spin state of either (83)Kr or (129)Xe.

20 uclear spin polarizations were P =29% for(83)Kr and P= 63% for (129)Xe.

21 ensity for the advancement of in vivo hp (83)Kr MRI.

22 xplored approach in the generation of hp (83)Kr that can likewise be used for the production of hp (1

23 ast also complicate the production of hp (83)Kr.

24 Hyperpolarized (hp) (83)Kr is a promising MRI contrast agent for the diagnosis o

25 only NMR active, stable krypton isotope (83)Kr (spin I = (9)/(2)) is explored as a novel probe for p

26 Chemical shifts and line widths of (83)Kr are moderately dependent on small fluctuations in the

27 ver, the distinct physical properties of (83)Kr that enable unique MRI contrast also complicate the p

28 Highly spin-polarized (83)Kr can now be purified for the first time, to our knowle

29 It is demonstrated that (83)Kr NMR spectroscopy of nanoporous or microporous materia

30 The (83)Kr chemical shifts observed in the investigated material

31 omagnetic ratio and low abundance of the (83)Kr isotope.

32 The (83)Kr line width in most of the studied cases is quadrupola

33 atmospheric noble gases ((20)Ne, (36)Ar, (84)Kr, (132)Xe) with respect to air-saturated water (ASW).

34 Additionally, lack of correlation of (84)Kr/(36)Ar and (132)Xe/(36)Ar fractionation levels along

35 noble gases, with particular emphasis on (84)Kr and (132)Xe.

36 Radiokrypton isotopes ((81)Kr and (85)Kr) are ideal tracers and chronometers of various enviro

37 d sampling strategy are validated by (i) (85)Kr and (39)Ar analyses that show the samples to be free

38 , Ni, Co, or Fe) for their capability in (85)Kr separation and storage using a two-bed breakthrough m

39 these volatile radionuclides, including (85)Kr.

40 radionuclides such as tritium, (14)C, or (85)Kr will become blurred in the significant background of

41 H, (14)C, (35)S), gaseous radionuclides ((85)Kr, (133)Xe, (135)Xe) or radionuclides with very long ha

42 laser-induced fluorescence detection using a Kr+ ion laser.

43 a was determined to be 33 m2 g(-1) according Kr sorption data.

44 ontaining an E-box-like motif from the Aedes Kr-h1 gene promoter specifically interacted with a prote

45 rger set of (noble) gases (N(2), He, Ar, and Kr) combined with a physically meaningful excess air mod

46 transcription factors such as S59, eve, and Kr, all of which are observed in subsets of the nautilus

47 s, osmium-isotope ratios and D/H, Ar/H2O and Kr/Xe ratios such that no primitive material similar to

48 ith a precision of better than 4% for He and Kr, and with a precision of 1% for Ar, N(2), and O(2) in

49 ) specifies the third-born U3 motoneuron and Kr misexpression induces ectopic U3 cells.

50 e identify the relative affinities of Xe and Kr atoms for as many as seven distinct binding sites.

51 Kr, and 2.5% or better for Ne/Xe, Ar/Xe, and Kr/Xe using air as the only calibration standard.

52 oves to 0.6% or better for Ne/Xe, Ar/Xe, and Kr/Xe when the data is calibrated using discrete water s

53 Using an Ar+/Kr+ laser, the fluorophore moieties were bleached to cre

54 that between Au(-) and a noble-gas atom (Ar, Kr, or Xe).

55 ng chain molecule (n-heptane) and atoms (Ar, Kr, and Xe).

56 ll gases (H2, D2, Ne, N2, CO, CH4, C2H6, Ar, Kr, and Xe) on the metal-organic framework (MOF) NU-1000

57 artial pressures of He, Ne (in dry gas), Ar, Kr, N2, O2, CO2, and CH4 in gaseous and aqueous matrices

58 e concentrations of dissolved gases (He, Ar, Kr, N(2), and O(2)) in groundwater to be determined quas

59 ysis of 2-formyl phenylazide isolated in Ar, Kr, and Xe matrixes and characterized by IR, UV-vis, and

60 ontinuous, real-time measurements of Ne, Ar, Kr, and Xe mole ratios in natural waters.

61 ontinuous or pulsed beams of 500 keV Ne, Ar, Kr, or Xe ions.

62 s (GaSb, GaAs, GaP) and ion species (Ne, Ar, Kr, Xe) to determine new parametric trends regarding nan

63 spectrometer (GC-MS) for analysis of Ne, Ar, Kr, Xe, N2, and O2 and an electron capture detector (GC-

64 taneous measurement of dissolved He, Ne, Ar, Kr, Xe, SF6, N2, and O2 concentrations in a single water

65 We studied Ar, Kr, CO, and N(2) going into and out of a chemically open

66 y is 0.7% or better for Ne/Kr, Ne/Ar, and Ar/Kr, and 2.5% or better for Ne/Xe, Ar/Xe, and Kr/Xe using

67 These data show interactions between Kr-h1, E93 and JH in the regulation of metamorphosis in

68 The transcriptional co-regulation by Kr-h1 and dFOXO may represent a broad mechanism by which

69 find that hunchback (Calb-hb), Kruppel (Calb-Kr), knirps (Calb-knl), giant (Calb-gt) and tailless (Ca

70 </= 1) clathrates (guest = H2O, N2, Ar, CH4, Kr, Xe, C2H4, C2H6, CH3F, CO2, H2S, CH3Cl, CH3OCH3, CH3B

71 of several clathrates (guest = H2O, N2, CO2, Kr, CH3F) is shown to occur in a single-crystal-to-singl

72 JH directs ecdysteroid action, controlling Kr-h1 expression which in turn regulates the other stage

73 A newly developed Kr purification system is based on conventional cryogeni

74 Similar work with dilute Kr and Xe in argon finds small frequency shifts in new f

75 e-outgrowth assay sensitized by the dominant Kr(irregular facets-1)(Kr(If-1)) allele, we show that th

76 ity was due to radionuclides of the elements Kr, Te, I, Xe, and Cs.

77 e first time, we utilize in situ high-energy Kr ion irradiation with transmission electron microscopy

78 Dopants did enhance Kr lamp APPI sensitivity when MeOH was used as the mobil

79 The FMOFCu shows an estimated Kr/Xe selectivity of 36 at 0.1 bar and 203 K.

80 stem described here is capable of extracting Kr of >98% purity from 5-125 L STP (standard temperature

81 tter than 1% for N2, O2, CO2, He, Ar, 2% for Kr, 8% for Xe, and 3% for CH4, N2O and Ne.

82 or krypton, and have comparable affinity for Kr and N(2).

83 The dual-regulation models developed for Kr also explain some of the properties of the even-skipp

84 l practical potential for separating Xe from Kr.

85 ne (JH) in inducing JH response genes (e.g., Kr-h1), suggesting that HDACs may be involved in JH acti

86 , the expression of two JH-responsive genes, Kr-h1 and Hairy, was dependent on both the ratio of ligh

87 terized by the successive expression of Hb-->Kr-->Pdm-->Cas-->Gh in many, but not all, neuroblasts.

88 fating factors, including Chinmo and the Hb/Kr/Pdm/Cas transcriptional cascade, within this diverse

89 These materials were found to have higher Kr/N(2) selectivity than current benchmark materials, wh

90 ex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complement

91 tuning and again co-crystallized with hROR2-Kr.

92 1b function are expected to reduce cardiac I Kr and enhance drug sensitivity, and represent a potenti

93 Cardiac I Kr is a critical repolarizing current in the heart and a

94 subunits, yet our current understanding of I Kr functional properties derives primarily from studies

95 by decreasing and/or increasing the rapid (I Kr) and slow (I Ks) components of delayed rectifying K(+

96 Upon reducing I Kr, the APs without EADs (no-EAD response) showed gradua

97 functional studies have demonstrated that I Kr channels are heteromers composed of both hERG 1a and

98 reduced rapid delayed rectifier current (I (Kr)).

99 nd to an almost complete disappearance of I (Kr), which depended on the intact RING domain of RFFL.

100 147 amino acids (HERG(Delta147)) abolished I(Kr), whereas a larger, 159-amino acid deletion (HERG(Del

101 In contrast, an I(Kr) chemical activator of primary effects in slowing cha

102 els of LQT1 and LQT2, which lack I(Ks) and I(Kr) (slow and fast components of delayed rectifying K(+)

103 st, activation of K(+) currents (I(Ks) and I(Kr) ) shortened the AP and eliminated both AP duration a

104 w that mRNA transcripts encoding I(Na) and I(Kr) channels (SCN5A and hERG, respectively) are associat

105 s) reduced both hERG current (I(hERG)) and I(Kr) Chronic activation of PKC by PMA (30 nM, 16 hours) i

106 used to evaluate action-potential (AP) and I(Kr) current properties at the cellular level.

107 lf AP-clamp was used to measure I(NaL) and I(Kr) during the AP in rabbit and porcine ventricular card

108 ic kidney cell line 293 (HEK293) cells and I(Kr) in isolated neonatal rat ventricular myocytes.

109 ition, and restored by combined I(NaL) and I(Kr) inhibitions.

110 zing potassium currents known as I(Ks) and I(Kr).

111 Baseline I(Kr) was negligible at CLs of 1000 to 320 ms, but increas

112 st our hypothesis that the balance between I(Kr) and I(NaL) affects repolarization stability in healt

113 Pretreatment with E-4031 to block I(Kr) (mimicking long QT syndrome 2) or with sea anemone t

114 In this model, drugs that block I(Kr) but not I(Ks) prolong repolarization in a way that s

115 Although many commonly used drugs block I(Kr), in certain individuals, this action evokes a parado

116 0.5 muM) prolonged AP duration and blocked I(Kr) in ventricular myocytes isolated from neonatal rats.

117 comparable amount of net charge carried by I(Kr) and I(NaL) during the physiological AP, suggesting t

118 creased by I(NaL) inhibition, increased by I(Kr) inhibition, and restored by combined I(NaL) and I(Kr

119 currents investigated (I(Na)(+)/I(CaL)(+)/I(Kr)(+)/I(NCX)(+)/I(f)(+)/I(to)(+)/I(K1)(-)/I(Ks)(-)), we

120 ating delayed rectifier potassium channel (I(Kr)) which plays an important role in cardiac repolariza

121 ating delayed rectifier potassium channel (I(Kr)).

122 xpression of the cardiac potassium channel I(Kr)/human ether a-go-go-related gene (hERG).

123 HERG increased the rapid component, I(Kr), of the delayed rectifier current, thereby accelerat

124 Consequently, I(Kr) was expected to contribute more to AP repolarization

125 Rapid delayed rectifier K(+) current (I(Kr)) and late Na(+) current (I(NaL)) significantly shape

126 f the delayed rectifier potassium current (I(Kr)) by verapamil is frequency-dependent.

127 pinavir of repolarising potassium current (I(Kr)) channels in neonatal mouse cardiac myocytes.

128 ions, the rapid delayed rectifier current (I(Kr)) density was increased.

129 hus rapid delayed rectifying K(+) current (I(Kr)) density, served to generate APD dispersion, high-fr

130 The rapidly delayed rectifier current (I(Kr)) has been described in ventricular myocytes isolated

131 ating delayed rectifier potassium current (I(Kr)) important for repolarization of cardiac action pote

132 mponent of delayed rectifier K(+) current (I(Kr)) in rabbit ventricular myocytes were similar to thos

133 ating delayed rectifier potassium current (I(Kr)) in the heart.

134 f the delayed rectifier potassium current (I(Kr)).

135 activating delayed rectifier K(+) current (I(Kr)).

136 he delayed rectifier repolarizing current (I(Kr)).

137 e rapid, outwardly rectifying K(+) current I(Kr) that is critical for repolarization of the cardiac a

138 g the rapid delayed rectifier K(+) current I(Kr), account for a significant proportion of congenital

139 underlies the cardiac repolarizing current I(Kr), is the unintended target for many pharmaceutical ag

140 block the rapid delayed rectifier current I(Kr), prolong action potential duration, and induce poten

141 ect block of the cardiac potassium current I(Kr)/hERG, which is crucial for terminal repolarization i

142 ect block of the cardiac potassium current I(Kr)/hERG.

143 -related gene (hERG)-encoded K(+) current, I(Kr) is essential for cardiac repolarization but is also

144 otein underlying the cardiac K(+) current, I(Kr), cause chromosome 7-linked long QT syndrome (LQT2).

145 rapid delayed rectifier potassium current, I(Kr), which flows through the human ether-a-go-go-related

146 t or slow delayed rectifier K(+) currents (I(Kr)/I(Ks)).

147 ition of delayed K(+) rectifying currents, I(Kr) (E4031; 0.5 micromol/L, n=3), shifted FFT spectra fr

148 I(Kr) suppressed alternans and decreasing I(Kr) increased alternans.

149 ized that a small molecule that diminishes I(Kr) block by a known hERG antagonist would constitute a

150 molecular pathway whereby KCR1 diminishes I(Kr) drug response.

151 Although the protein level of ERG (I(Kr) pore-forming, alpha, subunit) was not altered, the K

152 To test this idea experimentally, I(Kr) was measured as the E-4031-sensitive current in isol

153 g a unique specific chemical activator for I(Kr) that has a primary effect of causing a right shift o

154 We show that complete loss of functional I(Kr) in embryonic hearts leads to ventricular cell membra

155 identified in an LQT2 kindred did generate I(Kr), albeit with reduced amplitude compared with the wil

156 olayers infected with GFP (control), hERG (I(Kr)), or dominant negative mutant hERG G628S.

157 against four human cardiac currents (hERG [I(Kr)], hCav1.2 [L-Type I(Ca)], peak hNav1.5, [Peak I(Na)]

158 HERG/I(Kr) channels are blocked selectively by class III antiar

159 s: a well characterized inhibition of hERG/I(Kr) trafficking and a poorly understood increase of card

160 mulations, a fivefold regional increase in I(Kr) abbreviated the APD and hyperpolarized the resting p

161 Reduction in I(Kr) causes long QT syndrome, which can lead to fatal arr

162 er of rotation was significantly faster in I(Kr)-infected monolayers than controls.

163 sudden cardiac death due to a reduction in I(Kr)-mediated repolarization.

164 and AP-clamp recordings revealed increased I(Kr) current density due to attenuated inactivation, prim

165 of PKC by PMA (30 nM, 16 hours) increased I(Kr) in cardiomyocytes and the expression level of hERG p

166 ed on these data indicated that increasing I(Kr) suppressed alternans and decreasing I(Kr) increased

167 Ranolazine inhibited I(Kr) (IC50=11.5 micromol/L), late I(Na), late I(Ca), peak

168 (3) Alterations of I(Ks), I(Kr), and I(Na) (fast sodium current) in long-QT syndrome

169 Modifying I(Kr) may be a promising approach to suppressing alternans

170 Native I(Kr) channels are composed of two alpha subunits, hERG 1a

171 which gate more closely resembling native I(Kr) Our results showed that fentanyl blocked hERG1a/1b c

172 s using siRNA led to an increase in native I(Kr).

173 A computer model of I(Kr) based on these data indicated that increasing I(Kr)

174 upport of the latter result, inhibition of I(Kr) by E-4031 increased the maximal amplitude of alterna

175 tive evaluation suggests that elevation of I(Kr) by reducing voltage sensitivity of inactivation, not

176 ions or unintended pharmaceutical block of I(Kr) can lead to life-threatening arrhythmias.

177 is unknown whether the time dependency of I(Kr) enables it to control APD, conduction velocity (CV),

178 nuates the RRD and proarrhythmic effect of I(Kr) inhibition.

179 enous late I(Na) contributes to the RRD of I(Kr) inhibitor-induced increases in APD and BVR and to br

180 The magnitude of I(Kr) is paradoxically increased by an increase in extrace

181 al mapping, we investigated the effects of I(Kr) upregulation on reentry frequency, APD, CV, and WL i

182 (HERG) encodes the pore-forming subunit of I(Kr), a cardiac K(+) channel.

183 Inadvertent block of I(Kr), known as the acquired long QT syndrome (aLQTS), is

184 HERG is the molecular basis of I(Kr), which plays a critical role in repolarization.

185 everse rate dependence (RRD) of actions of I(Kr)-blocking drugs to increase the action potential dura

186 indicating a heterogeneous distribution of I(Kr).

187 at rapid rates and a predominant effect on I(Kr) at slow rates.

188 and Endo but had no significant effect on I(Kr) in either Epi or Endo.

189 Peak I(Kr) increased initially as CL was shortened from 1000 to

190 During APD alternans, peak I(Kr) was larger for the short than for the long action po

191 During an action potential, I(Kr) increased gradually to a maximum at -55 to -60 mV.

192 rapid component of the delayed rectifier (I(Kr)) may contribute importantly to action potential dyna

193 subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have th

194 eir effect on the rapid-delayed rectifier, I(Kr).

195 uce loss-of-function phenotypes and reduce I(Kr) currents either by the heteromeric assembly of non-

196 observed after chronic amiodarone (reduced I(Kr), I(Ks), late I(Na), and I(Ca)).

197 atory protein KCR1, which markedly reduces I(Kr) drug sensitivity, protects HERG through glucosyltran

198 Remarkably, I(Kr) and I(NaL) integrals in each control myocyte were hi

199 tated to LGL (HERG(Delta147-LGL)) restored I(Kr).

200 e increase in TDR induced by the selective I(Kr) blocker d-sotalol.

201 In all dogs, the selective I(Kr) blocker dofetilide was used to examine susceptibilit

202 s of repolarization delay as the selective I(Kr) blocker dofetilide, the combined ion-channel blocker

203 A selective I(Kr) blocker, E-4031 (1 microm), completely blocked mI(Kr

204 ssess the presence and behaviour of single I(Kr) channels in adult mouse cardiomyocytes (mI(Kr)).

205 This was confirmed by specific I(Kr) block with dofetilide, which prolonged AP significan

206 Conversely, HERG-G628S suppressed I(Kr) without significantly delaying repolarization.

207 Our data demonstrate that I(Kr) and I(NaL) are counterbalancing currents during the

208 These results indicate that I(Kr) contributes importantly to rate-related alterations

209 The I(Kr) blocker dofetilide prolonged APD in female and ORCH

210 The I(Kr) blocker E4031 (0.5 microM) together with 50 % reduct

211 riants showed decreased sensitivity to the I(Kr) inhibitor dofetilide, these changes could not be cor

212 2-G628S, a dominant negative mutant of the I(Kr) potassium channel alpha-subunit (G628S animals).

213 Reentry frequency was higher in the I(Kr)-infected monolayers (21.12 +/- 0.8 Hz; n=43 versus 9

214 APD(80) in the I(Kr)-infected monolayers was shorter (>50%) than control

215 , suggesting that outward K(+) current via I(Kr) and inward Na(+) current via I(NaL) are in balance d

216 However, whether I(Kr) is present in the adult mouse heart remains controve

217 m oxyfuel plants may be strongly enriched in Kr and Xe which are potentially valuable subsurface trac

218 r both resulted in a decrease or increase in Kr-h1 mRNA levels and its promoter activity, respectivel

219 thoprene tolerant (Met) was unable to induce Kr-h1 in the presence of HDAC1 or SIN3.

220 Methoprene induced Kr-h1 and suppressed E93 and induced formation of the su

221 aviolet second-harmonic focused tightly into Kr gas.

222 defects after irradiation using heavy ions (Kr(+), 400 keV) is inversely proportional to the grain s

223 sitized isogenic D. melanogaster strain, iso-Kr(If-1), we confirm this finding and present evidence s

224 l), the zebrafish ortholog of mafB/Kreisler (Kr), encodes a bZip transcription factor that is require

225 In neuroblast 7-1 (NB7-1), Kruppel (Kr) specifies the third-born U3 motoneuron and Kr misexp

226 r spatial localization of gap genes Kruppel (Kr) and giant (gt) and the pair-rule gene even-skipped (

227 rget genes, including the gap genes Kruppel (Kr), knirps (kni), and giant (gt), and the homeotic gene

228 anscription factors Hunchback (Hb), Kruppel (Kr), Pdm1/Pdm2 (Pdm) and Castor (Cas).

229 icient for establishing the initial Kruppel (Kr) expression pattern in central regions of the precell

230 Using Kruppel (Kr) and pannier (pnr) homologues of Megaselia as markers

231 Krypton (Kr) and xenon (Xe) adsorption on two partially fluorinat

232 separation of parts-per-million (ppm) level Kr from chemically airlike bulk gas.

233 of parts-per-million by volume (ppmv) level Kr from up to a few liters of bulk gas can be achieved b

234 ted with the clay content (relation to log10(Kr, linear), r2=0.40, n=19).

235 ity of the investigated soils (group 1, mean Kr, linear=3.7 L kg(-1), n=19), and was correlated with

236 a high retention of AgNM-300k (group 2, mean Kr, linear=1048 L kg(-1), n=6) either had a low (<5.1) o

237 TEM) and consecutive ion-irradiations: 1 MeV Kr(2+) (simulating alpha-recoil damage), followed by 400

238 Upon repolarization, ensemble-averaged mI(Kr) showed slow deactivation with a biexponential time c

239 er, E-4031 (1 microm), completely blocked mI(Kr) channel activity.

240 ) channels in adult mouse cardiomyocytes (mI(Kr)).

241 Of 314 patches, 158 (50.1%) demonstrated mI(Kr) currents as compared with 131 (42.3%) for the I(K1)

242 nnels with properties similar to those of mI(Kr), except for the more-negative activation of the HERG

243 Despite the abundant expression of mI(Kr), single-channel events were rarely observed during a

244 s of divalent cations prevent significant mI(Kr) opening under physiological conditions.

245 Single mI(Kr) channel activity was rarely observed at potentials p

246 ion potential parameters, confirming that mI(Kr) plays at best a minor role in repolarization of adul

247 ss of the colliding gas species (He, Ar, Ne, Kr, Xe, CH4, and N2).

248 rium), the accuracy is 0.7% or better for Ne/Kr, Ne/Ar, and Ar/Kr, and 2.5% or better for Ne/Xe, Ar/X

249 for four distinct CUO(Ar)(4-n)(Ng)(n) (Ng = Kr, Xe, n = 1, 2, 3, 4) complexes for each Ng.

250 Notably, Kr-h1 physically and genetically interacts with dFOXO in

251 PRC loss of function extends the ability of Kr to induce U3 fates and PRC gain of function causes pr

252 on increases during the N5 in the absence of Kr-h1 and promotes the development of adult structures.

253 Our models predict activation of Kr by Cad and clarify several other regulatory interacti

254 YC heterodimer mediates JH III activation of Kr-h1 and Hairy genes in the context of light-dependent

255 presses metamorphosis, and that depletion of Kr-h1 expression in Dicer-1 knockdown individuals rescue

256 miRNA depletion is due to a deregulation of Kr-h1 expression and that this deregulation is derived f

257 er, JH III was not effective in induction of Kr-h1 and Hairy gene expression in vitro in fat bodies o

258 Knockdown of Kr-h1 in N4 resulted in a precocious development of adul

259 However, low levels of Kr-h1 mRNA were detected in the fifth and last nymphal s

260 Down-regulation of Kr-h1 expression has been previously associated with ins

261 PR differentiation, transient repression of Kr-h1 represents a key step regulating neuronal maturati

262 ial mechanism, is required for repression of Kr.

263 We have also found that the 3'UTR of Kr-h1 mRNA contains a functional binding site for miR-2

264 ressurized at varying conditions under Xe or Kr gas, and X-ray data for six crystals, we identify the

265 A special case is the control of miR-2 over Kr-h1 transcripts, which determines adult morphogenesis

266 ed SBMOF-2) that is selective toward Xe over Kr under ambient conditions, with a Xe/Kr selectivity of

267 The high-precision Kr and Xe isotope data together suggest that Earth's int

268 Here, we report the discovery of primordial Kr in samples derived from Earth's mantle and show it to

269 s (<10(-12)) provided that 50 microL of pure Kr is available.

270 the data indicate that miR-2 miRNAs scavenge Kr-h1 transcripts when the transition from nymph to adul

271 Specifically, SAPO-34 membranes can separate Kr/Xe mixtures with Kr permeances as high as 1.2 x 10 (-

272 lite SAPO-34 membranes effectively separated Kr/Xe gas mixtures at industrially relevant compositions

273 In addition, SAPO-34 membranes separated Kr/Xe mixtures with Kr permeances as high as 1.2 x 10 (-

274 Here we show, by using in situ Kr ion irradiation in a transmission electron microscope

275 discovered during room temperature, in situ Kr ion irradiation of epitaxial nanotwinned Ag with an a

276 Here by using in situ Kr ion irradiation technique in a transmission electron

277 We found that Kr-h1 mutants show delayed larval development and altere

278 Cas play no detectable role, indicating that Kr either acts outside of the cascade identified in the

279 These experiments showed that Kr broke through the column first, followed by Xe, which

280 ulk gas can be achieved by concentrating the Kr under the chromatographic tails of major components.

281 ies showed an increase in acetylation in the Kr-h1 promoter region of cells exposed to JH III or dsHD

282 The subsequent refinement of the Kr pattern depends on the combination of Hb and the Gian

283 However, JH does not work through Kr-h1 but may work through transcription factors not yet

284 an inversion in sorption selectivity toward Kr at temperatures below 0 degrees C while FMOFZn does n

285 e, can be quantitatively reconstructed using Kr and Xe isotopes in groundwater.

286 os in the eggs laid by females injected with Kr-h1 double-stranded RNA.

287 of adult structures through interaction with Kr-h1 and E93 was also studied by the topical applicatio

288 4 membranes can separate Kr/Xe mixtures with Kr permeances as high as 1.2 x 10 (-7) mol/m(2) s Pa and

289 O-34 membranes separated Kr/Xe mixtures with Kr permeances as high as 1.2 x 10 (-7) mol/m(2) s Pa and

290 Meanwhile, Fe oxides do not react with Kr, Ar and Ne.

291 Conversely, Xe, Kr, Rb and Cs are unbound.

292 acidity of Hg(OTeF5)2 toward NgF2 (Ng = Xe, Kr) was investigated in SO2ClF solvent and shown to form

293 In the stoichiometric form, while Xe, Kr and Cs are not captured, Br, I and Te exhibit strong

294 over Kr under ambient conditions, with a Xe/Kr selectivity of about 10 and a Xe capacity of 27.07 wt

295 pore spaces are predicted to be efficient Xe/Kr solid-state adsorbents, but no experimental insights

296 The demand for Xe/Kr separation continues to grow due to the industrial si

297 chmark selectivity for Xe separation from Xe/Kr mixtures.

298 ation of similarly sized molecules (e.g., Xe/Kr mixtures).

299 enon adsorption capacity and a remarkable Xe/Kr selectivity under conditions pertinent to nuclear fue

300 The Xe/Kr separation in SBMOF-2 was investigated with experimen