ライフサイエンスコーパス: L-alanine

1 e of them, too (e.g. 1-deoxysphinganine from L-alanine).

2 strate L-serine to the alternative substrate L-alanine.

3 vibrational modes, with the exception being l-alanine.

4 erL were sufficient for germination in 50 mM L-alanine.

5 an operon and are required for catabolism of l-alanine.

6 athing motions in all systems except l-valyl-l-alanine.

7 rginine and pyruvate into 2-ketoarginine and L-alanine.

8 an alanine racemase inhibitor, and required L-alanine.

9 enosine, D-glucose, tryptophan, glycine, and L-alanine.

10 B are different, even though both respond to L-alanine.

11 e of L-[1-(13)C]alanine or unlabeled ((12)C) L-alanine.

12 vage of l-kynurenine to anthranilic acid and l-alanine.

13 ngest transport activities were specific for l-alanine.

14 with the wild-type enzyme in the presence of L-alanine.

15 expression of the operon in the presence of L-alanine.

16 elective fluorination from readily available L-alanine.

17 L-ornithine, L-2,4-diaminobutyric acid, and L-alanine.

18 s activity is influenced by the abundance of L-alanine.

19 D-aspartate, but not that of D-glutamate or L-alanine.

20 Finally, [2,3-(13)C(2),(15)N]-L-alanine (12) was prepared via alkylation of the lacton

21 ubjects (n = 29) using (18)F-dihydroxyphenyl-L-alanine ((18)F-DOPA) positron emission tomography.

22 ontrols) and underwent fluorodihydroxyphenyl-l-alanine ([18F]-DOPA) positron emission tomography to e

23 A small amount of 3,4-dihydroxyphenyl-l-alanine (2 mol %) can be detected by amino acid analys

24 a calix[4]resorcarene prepared from N-methyl-L-alanine (2) as a chiral NMR discriminating agent is co

25 -4-methylpentanoyl)-L-3-(tert-bu tyl)-alanyl-l -alanine, 2-aminoethyl amide), which has previously be

26 uced lactate, S-lactoylglutathione, N-acetyl-l-alanine, 2-hydroxyglutarate, and UMP levels.

27 that catalyses the hydrolysis of beta-cyano-L-alanine, a nitrile common in the plant environment and

28 o effect on organic nutrient (the amino acid l-alanine) absorption.

29 isotropic Raman spectra of L-alanyl-D-alanyl-L-alanine, acetyl-L-alanyl-L-alanine, L-vanyl-L-vanyl-L-

30 of CaDPA release beginning immediately after L-alanine addition leading to approximately 65% CaDPA re

31 (i) Following L-alanine addition, wild-type and gerD spores and spores

32 yme, catalyzes the ATP-dependent ligation of L-alanine (Ala) and UDP-N-acetylmuramic acid (UNAM) to f

33 ed at 160 degrees C from d-glucose (Glc) and l-alanine (Ala) as well as from fructosylalanine - the c

34 ved from alpha-aminoisobutyric acid (Aib) or l-alanine (Ala).

35 BOC-L-alanine alkyl esters and BOC-beta-alanine alkyl esters

36 followed by the pneumococcal N-acetylmuramyl-L-alanine amidase (amidase), the glycan strands of the p

37 PGRP-L is a Zn2+-dependent N-acetylmuramoyl-l-alanine amidase (EC 3.5.1.28), an enzyme that hydrolyz

38 CwlD in Escherichia coli results in muramoyl L-Alanine amidase activity but no muramic delta-lactam f

39 pPGRP-L1 and pPGRP-L2 have N-acetylmuramoyl-L-alanine amidase activity.

40 of AtlA is performed by the N-acetylmuramyl-l-alanine amidase AmiA, which cleaves the bond between t

41 which functions as both an N-acetylmuramoyl-L-alanine amidase and D-alanyl-glycine endopeptidase.

42 clusion, human PGRP-L is an N-acetylmuramoyl-l-alanine amidase and this function is conserved in prok

43 SLP shows weak homology to N-acetyl muramoyl-L-alanine amidase from Bacillus subtilis, and both the n

44 1,6-anhydro-N-acetylmuramic acid (anhMurNAc)-l-alanine amidase in Escherichia coli.

45 gonorrhoeae encodes a single N-acetylmuramyl-l-alanine amidase involved in cell separation (AmiC), as

46 al studies indicated that an N-acetylmuramyl-l-alanine amidase is responsible for cell wall breakdown

47 quences (R1ab-R2ab) of the N-acetyl-muramoyl-L-alanine amidase of Atl are essential for binding of hT

48 e is the first found for an N-acetylmuramoyl-l-alanine amidase PGRP that cleaves peptidoglycan at the

49 tsial protein, the putative N-acetylmuramoyl-l-alanine amidase RC0497.

50 demonstrate that PlyL is an N-acetylmuramoyl-L-alanine amidase that cleaves the cell wall of several

51 n protein 2 (PGLYRP2) is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglyca

52 n protein 2 (PGLYRP2) is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglyca

53 pneumococcal autolysin (N-acetylmuramic acid-L-alanine amidase).

54 amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme im

55 ns (triacylglycerol lipase, N-acetylmuramoyl-L-alanine amidase, flagellin, outer membrane protein A,

56 ization of the mycobacterial N-acetylmuramyl-L-alanine amidase, Rv3717.

57 sed cell lysis by activating N-acetylmuramyl-L-alanine amidase, the pneumococcal autolysin.

58 we showed that Lc-Lys is an N-acetylmuramoyl-L-alanine amidase, whereas Lc-Lys-2 is a gamma-D-glutamy

59 enzyme is a zinc-dependent N-acetylmuramoyl-l-alanine amidase.

60 t with a role for AmiC as an N-acetylmuramyl-l-alanine amidase.

61 amic acid residue by a cwlD-encoded muramoyl-L-Alanine amidase.

62 Three periplasmic N-acetylmuramoyl-l-alanine amidases are critical for hydrolysis of septal

63 The N-acetylmuramoyl-l-alanine amidases of Escherichia coli (AmiA, B and C) a

64 e three Tat substrates, the N-acetylmuramoyl-l-alanine amidases, AmiA and AmiC, and the cell division

65 proteins and found that two N-acetylmuramoyl-l-alanine amidases, encoded by amiA and amiC, elevated b

66 predicted product resembles N-acetylmuramoyl-L-alanine amidases.

67 of mutants defective for the N-acetylmuramyl-l-alanine amidases: AmiA, AmiB, and AmiC.

68 g an amino acid monomer as the precursor, an L-alanine amino acid derivatized with a protecting group

69 null (dko) mice were treated with glycine or L-alanine (amino acid control) for up to 15 weeks and vo

70 th peak serum levels of approximately 250 IU/L alanine aminotransferase and 420 IU/L aspartate aminot

71 otransferase (32.4 +/- 17.4 vs 21.5 +/- 6.9U/L), alanine aminotransferase (39.9 +/- 28.6U/L vs 23.8 +

72 time (pt) >100 sec, F7<1%, NH3 150 micromol/L, alanine aminotransferase 4079 U/L, total bilirubin le

73 re solved in the presence and absence of the l-alanine analogue, (R)-1-aminoethylphosphonic acid.

74 entrations were between 500 muM and 2 mM for l-alanine and </=10 mM for l-valine, rates of gerP spore

75 ation increased up to between 200 mM and 1 M l-alanine and 100 mM l-valine, and at 1 M l-alanine, the

76 rom the decarboxylative condensation between l-alanine and acyl-S-ACP were detected by GC-MS.

77 nants (His, Pro, Trp, and Tyr combining with L-alanine and Ala, Cys, His, Met, Phe, Pro, Ser, Trp, Ty

78 cid and L-cysteine and to a lesser extent by L-alanine and aminoisobutyric acid, but was not inhibite

79 hydrolytic cleavage of l-kynurenine to give l-alanine and anthranilic acid.

80 ta-decarboxylation of l-aspartate to produce l-alanine and CO(2).

81 borinates 11 and 12 followed by heating with l-alanine and crystallization afforded (R,R,S)-13 (27%).

82 A series of analogues (including the L-alanine and D-amino acid scanned peptides) was synthes

83 ternal aldimine formation with either AIB or L-alanine and DGD-PLP is a rapid equilibrium process, as

84 nation kinetics at varying concentrations of l-alanine and different temperatures were studied by mon

85 e cluster in the presence of l-alanine or of l-alanine and ethylamine in place of l-lysine.

86 germination via GerA, spore germination via L-alanine and GerB or GerB* was not inhibited by D-alani

87 ase) of M. leprae showed K(m) and V(max) for L-alanine and glycine similar to those of Mycobacterium

88 ying reduced proline uptake, could transport l-alanine and glycine, a phenotype suppressed by the S13

89 functional allele that could also transport l-alanine and glycine, displaying a specificity profile

90 cyl-l(but not d)-amino acids, such as glycyl-l-alanine and glycyl-l-phenylalanine, are also good acce

91 uct formation give ratios of 105 and 14 with L-alanine and isopropylamine as substrates, respectively

92 The ability of fetal arterial boluses of L-alanine and L-leucine to stimulate release of amino ac

93 robe the ionization state of the amino-acids l-alanine and l-proline at the air/water surface and in

94 Desert sample is found to contain homochiral L-alanine and L-serine indicating the presence of extant

95 enantioselective recognition response toward L-Alanine and limit of detection (LOD) value is determin

96 olysis of L-alanine-p-nitroanilide producing L-alanine and p-nitroaniline as products; the formation

97 The enzyme converts L-cysteine to L-alanine and sulfane sulfur (S(0)) in the form of a cys

98 catalyzes the fragmentation of l-cysteine to l-alanine and sulfane sulfur in the form of a cysteine p

99 decomposing cysteine or selenocysteine into L-alanine and sulfur or selenium, respectively.

100 inants that are released during germination, l-alanine and the 1:1 chelate of Ca(2)(+) and dipicolini

101 (Ald) catalyzes the oxidative deamination of L-alanine and the reductive amination of pyruvate.

102 concentrations (50, 75, 100, and 150 mM) of l-alanine and three different temperatures (30, 37, and

103 turating and subsaturating concentrations of l-alanine and with CaDPA.

104 alanine racemase with its natural substrate (L-alanine) and cofactor (pyridoxal 5'-phosphate).

105 gle Bacillus cereus spores in both nutrient (l-alanine) and non-nutrient (Ca-dipicolinic acid (DPA))

106 N delivered as nitrate, amino acid monomer (l-alanine) and short peptide (l-tetraalanine), and the r

107 ent inhibitor of wild-type Trpase, oxindolyl-L-alanine, and does not exhibit the pK(a) of 6.0 seen in

108 mino-1-cyclobutanecarboxylic acid (ACBC) and L-alanine, and full agonists glycine and D-serine.

109 L-alanyl-L-alanine, L-alanyl-glycine, glycyl-L-alanine, and glycyl-glycine, in which we attempt to is

110 cids, and GerA interacts only with L-valine, L-alanine, and its analogs.

111 of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomer

112 l-arginine, l-glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.

113 , glycine, L-lysine, L-arginine, L-cysteine, L-alanine, and L-proline--in aqueous solution adsorbed a

114 helical and beta-sheet conformations of poly-L-alanine, and polyglycine, are presented.

115 r is instantaneously hydrolyzed to [1-(13)C]-l-alanine, and subsequently metabolized to [1-(13)C]lact

116 inA is induced in the presence of beta-cyano-L-alanine, and the beta-cyano-L-alanine precursors cyani

117 ytic base for the conversion of D-alanine to L-alanine, and the present results show that, at least s

118 and the carboxyl moieties of the inhibitor d,l-alanine, and the substrate ACC by analogy, coordinate

119 nprotonated for binding glycine or oxindolyl-L-alanine, and, by inference, L-serine.

120 spores more readily germinate in response to l-alanine as a co-germinant.

121 llows P. fluorescens SBW25 to use beta-cyano-L-alanine as a nitrogen source and to tolerate toxic con

122 ynurenine to yield 3-hydroxyanthranilate and L-alanine as part of the tryptophan catabolic pathway le

123 is an aminoacyl ligase that adds l-serine or l-alanine as the first amino acid of a dipeptide branch

124 ed for growth on a minimal medium containing L-alanine as the major source of carbon.

125 d mutants grew poorly in minimal medium with L-alanine as the sole nitrogen source, reaching a satura

126 cine, N-acetyl-L-phenylalanine, and N-acetyl-L-alanine at 298.35K by porcine kidney acylase I (EC 3.5

127 etching modes was observed for (13)C-labeled l-alanine at the carboxylate carbon site, which was conf

128 gainst S. aureus, inoculated in a 1.0% d- or l-alanine-augmented trypticase soy broth medium.

129 ond gene, dat, can support slow growth of an L-alanine auxotroph.

130 res in melanoidins formed from d-glucose and l-alanine between 130 and 200 degrees C.

131 hypothesis that exposure to beta-methylamino-L-alanine (BMAA) could play a role in various neurodegen

132 beta-methylamino-L-alanine (BMAA) has been linked to several interrelated

133 beta-N-methylamino-l-alanine (BMAA) has been suspected of being involved in

134 toxic nonprotein amino acid beta-methylamino-l-alanine (BMAA) in the Guam ecosystem.

135 beta-methylamino-l-alanine (BMAA) is a naturally occurring nonprotein ami

136 beta-N-methylamino-l-alanine (BMAA) is a nonproteinogenic amino acid that h

137 to the environmental toxin beta-methylamino-L-alanine (BMAA) is linked to amyotrophic lateral sclero

138 of the genus Nostoc produce beta-methylamino-l-alanine (BMAA), a neurotoxic nonprotein amino acid.

139 beta-N-Methylamino-L-alanine (BMAA), a probable cause of the amyotrophic la

140 he environmental neurotoxin beta-methylamino-L-alanine (BMAA).

141 to AmpD, which is specific for the anhMurNAc-l-alanine bond, AmiD also cleaved the bond between MurNA

142 Inosine and L-alanine both play major roles as cogerminants with sev

143 s the tryptophan (Trp) analog 3-benzothienyl-l-alanine (Bta) with an imino-to-sulfur substitution in

144 c operon (dad) in the absence of the inducer L-alanine but also to a decreased expression of the oper

145 t encodes the spore's germinant receptor for L-alanine but not by overexpression of gerA operon homol

146 havior in the binding of l-phenylalanine and l-alanine but not in that of bicarbonate or l-arginine.

147 growth in high concentrations of beta-cyano-L-alanine, but also resulted in increased root elongatio

148 ) receptor responded to beta-alanine but not L-alanine by elevating intracellular [Ca(2+)], stimulati

149 molar mass distribution of end-charged poly-l-alanine by free solution CE, molar mass distribution o

150 eria, other than the reported replacement of l-alanine by glycine in the peptide side chains.

151 l-Alanine compounds are recognized as potent and selecti

152 ere increased markedly, in particular at low L-alanine concentrations, by overexpression of the trici

153 The dad operon is inducible by l-alanine, d-alanine, and l-valine, and induction is dep

154 In most bacteria, the peptides consist of l-alanine, d-glutamate, meso-diaminopimelic acid (mDAP)

155 om lipid I are predominantly N-acetylmuramyl-L-alanine-D-glutamate-meso-diaminopimelic acid-D-alanyl-

156 n mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthet

157 NAD(H)-dependent L-alanine dehydrogenase (EC 1.4.1.1) (Ald) catalyzes the

158 nt-starved tuberculosis models and codes for l-alanine dehydrogenase (MtbAld; Rv2780).

159 The produced NH(3) was in situ reacted with l-alanine dehydrogenase to generate alanine with NADH as

160 The coproduct, pyruvate, was consumed by l-alanine dehydrogenase to regenerate alanine and push t

161 function mutations in ald (Rv2780), encoding L-alanine dehydrogenase, were associated with unexplaine

162 rmined by a coupled reaction with NAD(+) and L-alanine dehydrogenase.

163 en (MV(*+)) and NADH for the nitrogenase and l-alanine dehydrogenase.

164 ation in the absence of exogenous beta-cyano-L-alanine, demonstrating that beta-cyano-L-alanine nitri

165 All the phosphoramidates prepared were L-alanine derivatives with variations in the aryl moiety

166 We found that the L-alanine derived ProTides show anti-HIV activity at non

167 he recent report of 5, 5'-di(dihydroxyphenyl-L-alanine) (diDOPA) cross-links in byssus has raised que

168 competitive inhibitors glycine and oxindolyl-L-alanine display single pK(i) values of 7.3.

169 o the reaction of L-kynurenine, beta-benzoyl-L-alanine does not exhibit a significant solvent isotope

170 nversion of tyrosine to 3, 4-dihydroxyphenyl-L-alanine (DOPA) and serine to O-phosphoserine accounts

171 ch proteins that contain 3,4-dihydroxyphenyl-L-alanine (dopa) and undergo extensive stabilization by

172 hly specific ensemble of 3,4-dihydroxyphenyl-l-alanine (DOPA) containing proteins.

173 ydroxylation of peptidyl-3,4-dihydroxyphenyl-l-alanine (Dopa) was observed during tyrosinase incubati

174 y only four amino acids: 3,4-dihydroxyphenyl-L-alanine (dopa), lysine, proline, and valine at approxi

175 The 3,4-dihydroxyphenyl-l-alanine (Dopa)-containing proteins of mussel byssus pl

176 nce and Y is modified to 3,4-dihydroxyphenyl-l-alanine (Dopa).

177 ts basic pI and abundant 3,4-dihydroxyphenyl-L-alanine (Dopa; 30 mol %), but is distinct in two respe

178 Of these two volume-sensitive conductances, L-alanine elicited a specific increase in GVD, whereas G

179 In contrast, a 10% L-alanine-enriched diet increased dSL levels and led to

180 Following cell transport, [1-(13)C]-l-alanine ethyl ester is instantaneously hydrolyzed to [

181 (13)C-labeled alanine derivative, [1-(13)C]-l-alanine ethyl ester, as a viable DNP probe whose chemi

182 Acetyl-L-alanyl-L-alanine exhibits a structure which is very similar to

183 and these enzymes are thought to convert the l-alanine germinant into d-alanine, a spore germination

184 ESLI again reached its maximum value; (4) in L-alanine germination of spores lacking both CLEs and un

185 remaining CaDPA was released rapidly; (2) in L-alanine germination of wild-type spores and spores lac

186 imilar but not identical ESLI pattern during L-alanine germination to that seen with cwlJ sleB spores

187 In contrast to l-alanine germination via GerA, spore germination via L-

188 istent with different pathways for CaDPA and L-alanine germination, (b) at T(release), the ESLI again

189 on L-arginine, suggesting the involvement of L-alanine in arginine catabolism.

190 miD also cleaved the bond between MurNAc and l-alanine in both muropeptides and murein sacculi.

191 e efficiency of the LIS device for detecting L-Alanine in human serum.

192 s measured with SAM bound to the cluster and l-alanine in place of l-lysine, with S-adenosyl-l-homocy

193 By incorporating L-alanine in place of L-serine, the mutant HSAN1-associa

194 kinetic studies with sarcosine and N-methyl-L-alanine in the absence or presence of a dead-end inhib

195 erent reactions with L-serine or beta-chloro-L-alanine in the presence or absence of indole.

196 observed for molecules with an odd number of l-alanines in the side chains.

197 Supplementation with l-serine or removal of l-alanine independently restored normal growth patterns

198 The L-alanine-induced activation of GVD was significantly re

199 thesized that Alr2 could affect C. difficile l-alanine-induced spore germination in a defined medium.

200 r investigated how microbial modification of l-alanine influenced plant carbon (C) and N recovery.

201 the enzyme serine palmitoyltransferase uses l-alanine instead of l-serine as its amino acid substrat

202 action of the potassium form of DGD-PLP with L-alanine is 24 s(-1).

203 N-Methyl-L-alanine is a good alternate substrate, exhibiting a k(

204 Beta-benzoyl-L-alanine is a good substrate of kynureninase from Pseud

205 We recently reported that l-alanine is a preferred carbon source for P. aeruginosa

206 Of these, l-alanine is an effective co-germinant and is also a ger

207 Similarly, competition for l-alanine is complete within a few minutes in soil, wher

208 Further coupling of phosphorochloridate of L-alanine isopropyl ester (13) with FMCA gave its phosph

209 The primary [2-(2)H]-L-alanine KIE on the transamination half-reaction is uni

210 l range of 66-90 cm(-1), or 2.0-2.7 THz, for L-alanine (L-Ala) and four L-Ala compounds in which hydr

211 te to form phosphonoacetaldehyde (P-Ald) and L-alanine (L-Ala).

212 3,4-Dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesia (LID) is a debilit

213 on in the development of 3,4-dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesia.

214 four zwitterionic model dipeptides, L-alanyl-L-alanine, L-alanyl-glycine, glycyl-L-alanine, and glycy

215 B, enabling it to recognize more efficiently l-alanine, l-azetidine-2-carboxylic acid, and glycine wi

216 The transported substrates L-alanine, L-glutamine, and alpha-(methylamino)isobutyra

217 transport of neutral amino acids, including l-alanine, l-glutamine, and l-histidine, across the plas

218 ed analysis of MGL interaction with glycine, l-alanine, l-norvaline, and l-cycloserine was performed

219 hPAT1 interacted with glycine, L-alanine, L-proline, alpha-aminoisobutyrate (AIB) and g

220 L-alanyl-D-alanyl-L-alanine, acetyl-L-alanyl-L-alanine, L-vanyl-L-vanyl-L-valine, L-seryl-L-seryl-L-s

221 e N-(4-morpholine)carbonyl-beta-(1-naphthyl)-L-alanine-L-leucine boronic acid (MLN-273), an analogue

222 UDP-N-acetylmuramic acid:L-alanine ligase (MurC) catalyzes the addition of the fi

223 The bacterial UDP-N-acetylmuramyl-L-alanine ligase (MurC) from Escherichia coli, an essent

224 scherichia coli, MurC (UDP-N-acetyl-muramate:L-alanine ligase) of M. leprae showed K(m) and V(max) fo

225 that a single neurotoxin, beta-N-methylamino-L-alanine, may be produced by all known groups of cyanob

226 tevia glycine ethyl ester (ST-GL) and stevia l-alanine methyl ester (ST-GL), were synthesised and cha

227 ggests that the relative abundance of D- and L-alanine might be linked with cytosolic pool of D and L

228 However, l-glutamine and l-alanine model reactions showed the same browning index

229 of the substituted deuterium atom(s) in the L-alanine molecule, and the atoms contributing to the ab

230 xidize other secondary amino acids (N-methyl-L-alanine, N-ethylglycine, and L-proline), but N,N-dimet

231 The Km values for L-alanine, NAD+, pyruvate, NADH, and NH4+ were estimated

232 ano-L-alanine, demonstrating that beta-cyano-L-alanine nitrilase activity can have a significant effe

233 n the peptidoglycan of Mycobacterium leprae, L-alanine of the side chain is replaced by glycine.

234 ial for normal spore germination with either L-alanine or a mixture of L-asparagine, D-glucose, D-fru

235 Apstatin analogues lacking the L-alanine or having hydroxyproline in place of the proli

236 germination in C-cpe isolates only; and (ii) L-alanine or L-valine induced significant germination of

237 germination of Bacillus subtilis spores with L-alanine or L-valine, and these germinations were stimu

238 th l-asparagine, fructose, and K+ and either L-alanine or L-valine.

239 SAH bound to the cluster in the presence of l-alanine or of l-alanine and ethylamine in place of l-l

240 Because mutant SPT preferentially uses l-alanine over its canonical substrate l-serine, we also

241 aining VanX exhibit saturation kinetics when L-alanine-p-nitroanilide is used as the substrate with K

242 (II), or Ni(II), catalyzes the hydrolysis of L-alanine-p-nitroanilide producing L-alanine and p-nitro

243 underwent simultaneous fluorodihydroxyphenyl-l-alanine PET (18F-DOPA-PET) and resting state functiona

244 is achieved with (18)F-fluorodihydroxyphenyl-l-alanine PET, somatostatin receptor SPECT, CT, or MR im

245 her oxygen linking its aromatic rings and an l-alanine polar side chain.

246 L-Alanine polypeptide thin films were synthesized via at

247 ducted a prospective [(18)F]-dihydroxyphenyl-L-alanine positron emission tomography study in antipsyc

248 of beta-cyano-L-alanine, and the beta-cyano-L-alanine precursors cyanide and cysteine.

249 erminate more efficiently in the presence of l-alanine, presumably because of their inability to conv

250 The l-alanine prodrug 8 (also known as brivanib alaninate/BM

251 The l-alanine prodrug of 12, BMS-582664 (21), is currently u

252 odrug phosphoramidate diastereochemistry (D-/L-alanine, R-/S-phosphoryl) in vitro and in vivo.

253 ion also yielded CBL(P113S), which catalyzes l-alanine racemization with a poor Km (58 mm) but a high

254 111, which acts as the catalytic acid during l-alanine racemization.

255 Furthermore, titration with L-alanine resulted in the appearance of an enzyme-substr

256 nation sphere amino acid, with D-leucine and L-alanine resulting in exclusively 3- and 4-coordinate s

257 That d-alanyl-l-alanine shows little activity as an acceptor suggested

258 es in production of muramic delta-lactam and L-alanine side chains and a slight increase in cross-lin

259 als of N-H, C-N, and C-H oscillations in the l-alanine spectrum are prone to inhomogeneous broadening

260 to beta-alanine from malonate semialdehyde, l-alanine, spermine, dihydrouracil, and acryloyl-coenzym

261 ding and the histamine-releasing activity of l-alanine substitutions for the five lysine residues and

262 educed olfactory response to all three cues (l-alanine, taurocholic acid, food cue) tested, suggestin

263 ants to grow in concentrations of beta-cyano-L-alanine that would otherwise prove lethal.

264 beta-Benzoyl-l-alanine, the analogue of l-kynurenine lacking the arom

265 M l-alanine and 100 mM l-valine, and at 1 M l-alanine, the rates of germination of wild-type and ger

266 de frequency shifts in deuterium-substituted L-alanine, three of which have previously only been calc

267 e transamination products 2-ketoarginine and L-alanine, thus demonstrating the proposed biochemical r

268 lators of ATP-PRT and identify 3-(2-thienyl)-L-alanine (TIH) as an allosteric activator of this enzym

269 ause of their inability to convert exogenous l-alanine to d-alanine, but they respond normally to oth

270 catalytic base involved in the conversion of L-alanine to D-alanine.

271 he reversible, NAD+-dependent deamination of L-alanine to pyruvate and NH4+.

272 group of muramic acid and the amino group of l-alanine to release a peptide moiety.

273 Addition of 5 mM L-alanine to the bathing solution increased the whole ce

274 se capable of converting the spore germinant l-alanine to the germination inhibitor d-alanine.

275 noacyl-tRNA ligase that attaches L-serine or L-alanine to the stem peptide lysine of Lipid II in cell

276 onation to the ketimine intermediate for the L-alanine transamination half-reaction.

277 in the dead-time of the stopped-flow in the L-alanine transamination half-reaction.

278 to form alpha-ketobutyrate and ammonia) and L-alanine (transamination to form pyruvate), which have

279 omplex with its product UDP-N-acetylmuramoyl-L-alanine (UMA), the nonhydrolyzable ATP analogue AMPPNP

280 amic acid (UNAM) to form UDP-N-acetylmuramyl-L-alanine (UNAM-Ala).

281 derivatives, depending on both the number of l-alanine units in the oligopeptide segments and length

282 ng study we found that (18)F-dihydroxyphenyl-L-alanine uptake was elevated in both the substantia nig

283 Furthermore, nigral (18)F-dihydroxyphenyl-L-alanine uptake was positively related with the severit

284 as nigral and striatal (18)F-dihydroxyphenyl-L-alanine uptake were positively related in control subj

285 (1-hydroperoxy-4-oxocyclohexa-2,5-dien-1-yl)-L-alanine was formed.

286 The amino acid L-alanine was the only independent germinant in B. anthr

287 -2-methyl-1,1'-biphenyl-4-yl)carbonyl]amino}-L-alanine (WAY-211686) (IC(50) = 190 +/- 10 nM).

288 anthracis spores germinated with inosine and L-alanine, we previously determined kinetic parameters f

289 show that S-2-aminobutyrate and beta-chloro-L-alanine were alternate substrates.

290 , furfural, glyoxal, and methylglyoxal, with l-alanine were analyzed with Fourier transform infrared

291 germination of Bacillus subtilis spores with L-alanine were increased markedly, in particular at low

292 ate kinetics of the reaction of beta-benzoyl-L-alanine were investigated by rapid scanning stopped-fl

293 S253G and W351F could transport l-alanine, whereas T414S, despite displaying reduced pro

294 helical and beta-sheet conformations of poly-L-alanine, which is in agreement with the reported quant

295 In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to aspartic

296 urenine to produce 3-hydroxyanthranilate and l-alanine, while l-kynurenine is the substrate of many p

297 rmining step in the reaction of beta-benzoyl-L-alanine with kynureninase is C(beta)-C(gamma) bond cle

298 (14) C-labelled inorganic N and amino acid (l-alanine), with chase periods from 1 min to 24 h, to in

299 vibrational spectra of an alpha amino acid, l-alanine, with damage-free "aloof" electron energy-loss

300 glucose model reactions with l-glutamine and l-alanine yielded similar colored solutions.