ライフサイエンスコーパス: LAP

1 LAP blockade is a general property of melanin pigments,

2 LAP depends upon reactive oxygen species (ROS) generated

3 LAP functions to limit the immune response and is critic

4 LAP initiated 20 years ago, has been described for all h

5 LAP is not developing, has not been adopted for intermed

6 LAP is required for efficient degradation of the engulfe

7 LAP is triggered by engagement of the TIM4 receptor by e

8 LAP neutrophils also displayed slower kinetics ( approxi

9 LAP was required for TLR9 trafficking into a specialized

10 LAP+ and LAP- fractions were analyzed by immunofluoresce

11 LAPs have a role in insect defense and act as a regulato

12 and peripheral blood were collected from: 34 LAP, 10 healthy siblings, and nine healthy unrelated con

13 Distant recurrence was 14.6% LAP and 16.7% OPEN.Disease-free survival was impacted by

14 Local and regional recurrence was 4.6% LAP and 4.5% OPEN.

15 There were 7881 (17.8%) LAP and 36,359 (82.2%) OPEN performed in an average of 4

16 Nasal anti-CD3 induced a LAP(+) regulatory T cell that secreted high levels of IL

17 ll plants, whereas the stress-induced acidic LAPs (LAP-A) are expressed only in a subset of the Solan

18 P levels are significantly reduced, allowing LAP-mediated activation of the late promoter.

19 entional methods for leucine aminopeptidase (LAP) and pyrrolidonyl arylamidase (PYR) testing can be c

20 Leucine aminopeptidase (LAP) is an essential proteolytic enzyme and potential bi

21 s, and the reference leucine aminopeptidase (LAP).

22 l-Leucine aminopeptidases (LAPs) are implicated in the progress of many pathologica

23 Leucine aminopeptidases (LAPs) are present in animals, plants, and microbes.

24 Three distinct clusters emerged among LAP participants: a high responder group (high level of

25 OPEN (243), with 462 eligible for analysis (LAP = 240 and OPEN = 222).

26 mage, it was shown that the tomato LAP-A and LAP-N and the Arabidopsis thaliana LAP1 and LAP2 are mol

27 es, involved in both canonical autophagy and LAP, as markers of a predisposition for SLE.

28 teria infection on host Hsp60 expression and LAP-mediated bacterial adhesion, invasion, and transepit

29 tration results in expansion of Foxp3(+) and LAP(+) regulatory T cells (Tregs), suggesting oral deliv

30 duced a significant increase in Foxp3(+) and LAP(+) T cells in in vitro cultures.

31 different promoter activities of the HAP and LAP varieties.

32 gulatory elements differ between the HAP and LAP varieties.

33 ool to dissect the functions of the LAP* and LAP isoforms.

34 LAP+ and LAP- fractions were analyzed by immunofluorescence and m

35 Discordances between NucAmino and LAP occurred in 512 (16.9%) of the 3,029 sequences conta

36 ulosis to evade killing by NADPH oxidase and LAP.

37 the active form of C/EBP-beta (also known as LAP), acting as a critical molecular unit that controls

38 AP), latent TGF-beta and/or active TGF-beta (LAP/TGF-beta) is localized on the cell surface of Foxp3(

39 d and activate the latent form of TGF-beta1 (LAP-TGF-beta1).

40 ungal particles that are normally cleared by LAP.

41 ignment that was preferable to that found by LAP in that it was more likely to codon align insertions

42 0001), only 15% of patients were operated by LAP and intermediate (or major) resections were performe

43 The proportion of resections performed by LAP was inversely related to annual caseload.

44 Phagocytosis by LAP macrophages was reduced approximately 40% compared t

45 y WTR (aHR 1.9 [1.4-2.6]) and black women by LAP (aHR 2.2 [1.4-3.5]).

46 a transposable 13-amino acid peptide called LAP (LplA Acceptor Peptide).

47 sing CD4(+) regulatory T cells (CD4(+)CD25(-)LAP(+) cells with upregulated IL-10 and transforming gro

48 CD4(+)LAP(+) T cells are hypoproliferative compared with CD4(+

49 In vitro generated CD4(+)LAP(+)Foxp3(-) T cells were suppressive in vitro, inhibi

50 Adoptive transfer of orally induced CD4(+)LAP(+) Tregs ameliorated metabolic and cytokine abnormal

51 -6 abrogated the in vitro induction of CD4(+)LAP(+) T cells by STAT3-dependent inhibition of Lrrc32 (

52 The in vitro activation of CD4(+)LAP(-) T cells results in the generation of LAP(+) Tregs

53 These CD4(+)LAP(+) T cells lack Foxp3 but express TGF-betaR type II

54 ls are hypoproliferative compared with CD4(+)LAP(-) T cells, secrete IL-8, IL-9, IL-10, IFN-gamma, an

55 lent reliability towards monitoring cellular LAP activity in HepG2 cells.

56 ed in real-time active profiling of cellular LAP activity in HepG2 cells and effect of LAP inhibitor.

57 sible for the abnormal neutrophil chemotaxis LAP.

58 ), performed between 2008 and 2013, compared LAP and OPEN resection of stage II/III rectal cancer, wi

59 specific derivatization of azide-conjugated LAP in cells.

60 re we describe the consequences of defective LAP in vivo.

61 with a reasonable selectivity versus dizinc LAP.

62 cell surface receptor for the latent domain (LAP) of the multifunctional cytokine TGF-beta.

63 Here we report that C/EBPbeta (LAP) DNA binding is inhibited by N-terminal sequences an

64 y of another isoform of C/EBPbeta, C/EBPbeta-LAP, and might control liver biology through the regulat

65 ntify all patients who underwent an elective LAP or OPEN between 2007 and 2012.

66 ls in Caco-2 cells and consequently enhanced LAP-mediated L. monocytogenes adhesion but not invasion

67 The entire LAP completes in less than 20 min while using only a ten

68 Three-year LRFS for R0 resection was 86% for LAP cancer and 84% for RRC (P = 0.817).

69 g required for autophagy, is dispensable for LAP induced by uptake of microbes or dead cells.

70 dditional surface localization mechanism for LAP/TGF-beta, which may play an important role in contro

71 APs as well as suggesting new mechanisms for LAP action in the defense of solanaceous plants against

72 PAMPs and melanin removal, are necessary for LAP activation and fungal killing.

73 why its inhibitory activity is selective for LAP*.

74 rochemical signal is distinctly specific for LAP and free of other electroactive biological interfere

75 in 10 min and that it is highly specific for LAP fusion proteins over all endogenous mammalian protei

76 Of 100 exenterative operations, 55 were for LAP cancer and 45 for RRC.

77 l and highly sensitive fluorescent assay for LAPs based on substituted aminopyridines as fluorescent

78 ith increase in the frequencies of Foxp3(+), LAP(+), and GARP(+) T cells.

79 was lower in activated peripheral blood from LAP patients, we investigated the Maresin 1 (MaR1) biosy

80 By 10 months, colonies derived from LAP+ cells increased so that up to 35% of the liver was

81 Macrophages from LAP patients had a lower level of expression of 12-lipox

82 ed with long-acting cabotegravir (GSK1265744 LAP) pharmacokinetic variability, the current study was

83 oth IM and SC locations following GSK1265744 LAP administration.

84 understand the biodistribution of GSK1265744 LAP and its associated pharmacokinetics.

85 to a maximum volume at 2days post-GSK1265744 LAP administration, while the Vehicle depot did not sugg

86 employed to examine the temporal GSK1265744 LAP biodistribution in rat following either IM or SC adm

87 of macrophages trafficking to the GSK1265744 LAP and Vehicle depot sites.

88 The GSK1265744 LAP depot volume increased rapidly by day 2 in the IM in

89 resent in the depot region of the GSK1265744 LAP injected gastrocnemius while the Vehicle injected ga

90 ated a population of gastrointestinal-homing LAP(+)Foxp3(-) Treg cells.

91 However, the molecular mechanism(s) of how LAP/TGF-beta is anchored on the cell membrane is unknown

92 However, it remains unclear how LAP shapes both the activation and outcome of the immune

93 trusion and goblet cell exocytosis; however, LAP-induced cell junction opening may be an alternative

94 ve characterized a novel population of human LAP(+) Tregs that is different from classic CD4(+)Foxp3(

95 are due to defective engulfment and impaired LAP-mediated clearance of apoptotic germ cells as miR-47

96 and Capnocytophaga sp were most abundant in LAP.

97 cis together indicates sites of future BL in LAP.

98 ynergistic interaction of this consortium in LAP causation is possible and is the subject of ongoing

99 Therefore, defects in LAP, rather than canonical autophagy, can cause SLE-like

100 old-higher endotoxin levels were detected in LAP plasma compared with that from healthy participants

101 For R0 resections only, DFS in LAP cancer was 76% and 57% in RRC (P = 0.212).

102 from diseased (DD) and healthy sites (DH) in LAP and from healthy sites in HS and HC and analyzed by

103 Nine mediators were elevated in LAP diseased sites as compared with healthy sites (TNFal

104 r systemic levels of endotoxin were found in LAP, which correlates with an exacerbated local inflamma

105 R0 rates were significantly higher in LAP cancer than in RRC (91% vs 62%, P = 0.001).

106 Hepatocyte-specific expression of hLAL in LAP-Tg/KO triple mice reduced the liver size to the norm

107 ponents of the autophagy pathway involved in LAP.

108 Expression of C/EBPbeta could be mimicked in LAP/LAP* isoform knockin DCs, whereas the short isoform

109 which the LTBP-binding cysteine residues in LAP TGF-beta1 were mutated to serine precluding covalent

110 , LPS-induced hyper-inflammatory response in LAP can be partially modulated by periodontal therapy.

111 However, the clinical effect of this SNP in LAP is ethnicity dependent, destructive (increases LAP i

112 was strongly associated and site-specific in LAP.

113 ethnicity dependent, destructive (increases LAP incidence), and complex with mechanisms still to be

114 lomyelitis, diabetes, and lupus) by inducing LAP(+) regulatory T cells.

115 Repeated injection of dying cells into LAP-deficient, but not LAP-sufficient, mice accelerated

116 When dying cells are injected into LAP-deficient mice, they are engulfed but not efficientl

117 Of interest, both the large isoform (LAP-2) and the small isoform (LIP) of C/EBP-beta can exe

118 -hLAL transgene with lal(-/-) knockout (KO) (LAP-Tg/KO) triple mice.

119 anoic acid, and the most efficiently labeled LAP clones were isolated by fluorescence activated cell

120 nts, whereas the stress-induced acidic LAPs (LAP-A) are expressed only in a subset of the Solanaceae.

121 The neutral LAPs (LAP-N and its orthologs) are constitutively expressed an

122 ween mean ADC value of 12 lymphadenopathies (LAP) associated with inflammatory breast diseases (granu

123 enase ( approximately 30%) and reduced MaR1 (LAP versus healthy controls [HC], 87.8 +/- 50 pg/10(6) c

124 was largely restored in macrophages missing LAP components (Nox2, Rubicon, Beclin, Atg5, Atg7, or At

125 this assay was a useful tool for monitoring LAP activities in extracts from cancer cell lines, as we

126 The neutral LAPs (LAP-N and its orthologs) are constitutively expres

127 Here, we report the discovery of a new LAP biosynthetic gene cluster in the genome of Rhizobium

128 nes required for canonical autophagy but not LAP do not display defective dying cell clearance, infla

129 n of dying cells into LAP-deficient, but not LAP-sufficient, mice accelerated the development of SLE-

130 For both sexes, quartile 4 of LAP carried increased risks for tobacco-exposed persons

131 The ability of LAP to attenuate autoimmunity likely occurs through the

132 f the engulfed corpse, and in the absence of LAP, engulfment of dead cells results in increased produ

133 hibits NADPH oxidase-dependent activation of LAP by excluding the p22phox subunit from the phagosome.

134 is capable of monitoring in-situ activity of LAP in live cells.

135 LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a t

136 th subsequent metalloproteolytic cleavage of LAP represents a major mechanism of TGF-beta activation

137 Consequences of LAP deficiency include a decreased capacity to clear dyi

138 ar LAP activity in HepG2 cells and effect of LAP inhibitor.

139 Here, we describe the engagement of LAP upon uptake of apoptotic, necrotic, and RIPK3-depend

140 , and recombinant IL-2 induced expression of LAP on naive CD4(+) T cells, independent of Foxp3 or exo

141 L-10 or TGF-beta prevented the generation of LAP(+) Tregs and Foxp3(+) Tregs in vivo, and the LAP(+)

142 )LAP(-) T cells results in the generation of LAP(+) Tregs, which is further amplified by IL-8.

143 g mechanisms predicting the heterogeneity of LAP activity, severity, and response to treatment.

144 The impact of LAP to immune regulation is best characterized in profes

145 acterial titers), and restored impairment of LAP phagocytes.

146 of the OPEN, P<0.0001) and the incidence of LAP biopsies increased after 2009.

147 Th2 responses, resulted in the induction of LAP(+) regulatory T cells and suppression of ongoing art

148 s was associated with a lack of induction of LAP(+) regulatory T cells.

149 lerance, strongly decreased the induction of LAP(+) Tregs.

150 A approximately 10(7) library of LAP variants was displayed on the surface of yeast cells

151 Although the mechanism of LAP-A action is unknown, it has been presumed that LAP p

152 ped an in vitro model to study modulation of LAP(+) on CD4(+) T cells.

153 monitor cisplatin induced overexpression of LAP activity in HepG2 cells in presence and absence of b

154 Overexpression of LAP is directly linked with some fatal physiological and

155 nerates a newly differentiated population of LAP(high)CD103(high) CD8(TGF-beta) Treg cells, which rep

156 arbamate (Leu-FC) for selective profiling of LAP activity in live cells.

157 Herein, we provide a detailed review of LAP and its known roles in the immune response and provi

158 These data provide insight into the role of LAP as a virulence factor during intestinal epithelial i

159 More than a third of LAP+ fetal hepatocytes expressed ductal markers.

160 RNA against ANLN increased survival times of LAP-MYC mice, compared to mice given a control siRNA.

161 cheme was used to tag and image a variety of LAP fusion proteins in multiple mammalian cell lines wit

162 In plants, there are two classes of LAPs.

163 PHZ expands the known diversity of LAPs and may be used in the future as biocontrol agent f

164 ue to the compensatory function of two other LAP proteins, Erbin and Lano.

165 In our LAP participants, distinct patterns of LPS response were

166 s an exoprotease, leucine aminopeptidase (PA-LAP), which is coexpressed with several known virulence

167 by expressing the full-length proform of PA-LAP recombinantly in Escherichia coli (here termed, rLAP

168 read-out of a 5-parameter liver assay panel (LAP) on a portable, easy-to-use, fast and cost-efficient

169 Long-Acting Parenterals (LAPs) have been used in the clinic to provide sustained

170 ow (enriched with light absorbing particles, LAPs) facilitate the study of particle loads on the fate

171 ic surface protein, leucine amino peptidase (LAP).

172 pressed both the latency-associated peptide (LAP) and the PD-1 receptor, two markers of functional Tr

173 des that express latency-associated peptide (LAP) on their cell surface but do not express Foxp3.

174 that express the latency-associated peptide (LAP), a membrane-bound TGF-beta1.

175 of TGF-beta, the latency-associated peptide (LAP), and having regulatory properties in human peripher

176 ession levels of latency-associated peptide (LAP), CD103, PD-1, PD-L1, and CTLA-4, as compared with p

177 at pro-TGF-beta, latency-associated peptide (LAP), latent TGF-beta and/or active TGF-beta (LAP/TGF-be

178 dependent CD4(+) latency-associated peptide (LAP)-positive Tregs by oral administration of anti-CD3 a

179 associated with latency-associated peptide (LAP).

180 -bound TGF-beta (latency-associated peptide [LAP]) and have been shown to play an important role in t

181 e substrate, called "LplA Acceptor Peptide" (LAP).

182 Linear azol(in)e-containing peptides (LAPs) comprise a subclass of RiPPs that display outstand

183 -induced localized aggressive periodontitis (LAP) in African-American adolescents has been documented

184 Localized aggressive periodontitis (LAP) is a distinct form of early-onset periodontitis lin

185 sed with localized aggressive periodontitis (LAP) present an in vivo phenotype with depressed chemota

186 cts with localized aggressive periodontitis (LAP) who had proximal bone loss but minimal proximal car

187 gent for localized aggressive periodontitis (LAP), an aggressive form of periodontal disease that occ

188 ren with localized aggressive periodontitis (LAP).

189 ponse in localized aggressive periodontitis (LAP).

190 ren with Localized Aggressive Periodontitis (LAP).

191 toxin in localized aggressive periodontitis (LAP).

192 etallo-aminopeptidases (MAPs), PfA-M1 and Pf-LAP.

193 In contrast, inhibition of Pf-LAP was lethal to parasites early in the life cycle, pri

194 e onset of Hb degradation suggesting that Pf-LAP has an essential role outside of Hb digestion.

195 li cells employ LC3-associated phagocytosis (LAP) by recruiting autophagy member proteins to clear ap

196 LC3-associated phagocytosis (LAP) is a novel form of non-canonical autophagy where LC

197 monstrated that LC3-associated phagocytosis (LAP), a noncanonical autophagic process dependent on Rub

198 ophagy known as LC3-associated phagocytosis (LAP), in which phagosomes containing engulfed particles,

199 pathway termed LC3-associated phagocytosis (LAP), which promotes fungal killing.

200 ermed MAPLC3A (LC3)-associated phagocytosis (LAP), which results in optimal degradation of the phagoc

201 light chain 3 (LC3)-associated phagocytosis (LAP).

202 germ cells via LC3-associated phagocytosis (LAP).

203 ight-chain 3 (LC3)-associated phagocytosis" (LAP), lacked such defects.

204 athway called "LC3-associated phagocytosis" (LAP).

205 Here we show that plant LAPs are bifunctional.

206 chaperones and a new function for the plant LAPs as well as suggesting new mechanisms for LAP action

207 xpression of latency-associated polypeptide (LAP)/TGF-beta and after adoptive transfer also their pro

208 In practice, LAP instantaneously hydrolyze the Leu residue of the sub

209 cludes Lm by occupying the surface presented LAP receptor, heat shock protein 60 and ameliorates the

210 d in patients with locally advanced primary (LAP) cancer and recurrent rectal cancer (RRC).

211 arteannuin B; the low artemisinin producers (LAPs), which include the 'Meise', 'Iran#8', 'Iran#14', '

212 ity index (VAI), lipid accumulation product (LAP), body adiposity index (BAI) and the waist-to-height

213 e considered the lipid accumulation product (LAP; [WC enlargement*triglycerides]).

214 d alignment program Local Alignment Program (LAP) using 115,118 human immunodeficiency virus type 1 (

215 cross-breeding of liver-activated promoter (LAP)-driven tTA transgene and (tetO)7-CMV-hLAL transgene

216 arboring deletions of the core LAT promoter (LAP) region.

217 teractors includes lamina-associated protein LAP-1, myocyte nuclear envelope protein Syne1, BetaM its

218 t not the liver-enriched activating protein (LAP) version, represses ATF4 transcription.

219 -enriched transcriptional activator protein (LAP) isoform of CCAAT/enhancer binding protein beta (C/E

220 rly, CEBPB-liver-enriched activator protein (LAP) isoform overexpression suppresses MYO18B transcript

221 is a receptor for Listeria adhesion protein (LAP) during Listeria monocytogenes infection.

222 P) to express the Listeria adhesion protein (LAP) from a non-pathogenic Listeria (L. innocua) and a p

223 demonstrated that Listeria adhesion protein (LAP) promotes adhesion to intestinal epithelial cells an

224 he interaction of Listeria adhesion protein (LAP) with the host cell receptor (heat shock protein 60)

225 beta propeptide [latency associated protein (LAP)], and a latent TGF-beta binding protein (LTBP).

226 -length (liver-enriched activating protein* (LAP*)) isoform but not the slightly shorter (LAP) isofor

227 sing localization and affinity purification (LAP)-tagged dynein/dynactin subunits from bacterial arti

228 The AAPC of the incidence of real LAP increased more than that of real OPEN (7.0% vs 1.3%)

229 REDUCE LAP-HF I (Reduce Elevated Left Atrial Pressure in Patien

230 (REDUCE LAP-HF Trial [REDUCE LAP-HF]; NCT01913613; and REDUCE LA

231 ial [REDUCE LAP-HF]; NCT01913613; and REDUCE LAP-HF Randomized Trial I [REDUCE LAP-HF I]; NCT02600234

232 eft Atrial Pressure in Heart Failure (REDUCE LAP-HF I), the first randomized controlled trial of a de

233 ssure in Patients with Heart Failure (REDUCE LAP-HF) study was an open-label, single-arm, phase 1 stu

234 and REDUCE LAP-HF Randomized Trial I [REDUCE LAP-HF I]; NCT02600234).

235 (REDUCE LAP-HF Trial [REDUCE LAP-HF]; NCT01913613; and REDUCE LAP-HF Randomized Trial

236 d practice of laparoscopic liver resections (LAP), compared to open resections (OPEN).

237 sed to a 13-amino acid recognition sequence (LAP), catalyzed by a mutant of the Escherichia coli enzy

238 LAP*)) isoform but not the slightly shorter (LAP) isoform.

239 her, we concluded that inducible Ag-specific LAP(+) Tregs can suppress asthmatic lung inflammation an

240 eration, and transfer of sorted OVA-specific LAP(+) Tregs in vivo inhibited allergic eosinophilia and

241 Caco-2 cells more susceptible to subsequent LAP-mediated adhesion and translocation.

242 +)CD25(-) T cells, makes these cells surface LAP/TGF-beta-positive.

243 Furthermore, surface LAP/TGF-beta forms a complex with the molecular chaperon

244 er, is not involved in GARP-mediated surface LAP/TGF-beta.

245 P78 reduced the expression levels of surface LAP/TGF-beta.

246 The surface LAP/TGF-beta contains high-glycosylated, furin-processed

247 The optimal catalyst system (LAP 8-5-47) provided alpha-amino amides from an aldehyde

248 TCRgammadelta+LAP+ cells express antigen presentation molecules and fu

249 + regulatory T cells, although TCRgammadelta+LAP+ cells do not themselves express Foxp3.

250 Identification of TCRgammadelta+LAP+ regulatory cells provides an avenue for understandi

251 Here, we demonstrate that LAP is required for UV-induced immunosuppression and tha

252 P-A catalytic site mutants demonstrated that LAP-A chaperone activity was independent of its peptidas

253 We found that LAP activation also requires the genetic, biochemical or

254 alizing Abs against cytokines, we found that LAP induction was decreased in the presence of IL-6 and

255 action is unknown, it has been presumed that LAP peptidase activity is essential for regulating wound

256 Collectively, these data suggested that LAP-A has a role in modulating essential defenses agains

257 onolayers than a lap mutant, suggesting that LAP is involved in transepithelial translocation, potent

258 The LAP receptor is a stress response protein, Hsp60, but th

259 The LAP(+) Tregs strongly suppressed naive CD4(+) T cell pro

260 me rural adults of Xinjiang was high and the LAP was an effective indicator for the screening of MetS

261 and WHtR were all greater than 0.7, and the LAP was the index that most accurately identified MetS s

262 +) Tregs and Foxp3(+) Tregs in vivo, and the LAP(+) Tregs could also be generated concomitantly with

263 of the DBR2 gene from varieties of both the LAP and the HAP groups.

264 Its selectivity for the LAP* isoform also makes helenalin acetate an interesting

265 protein, Hsp60, but the precise role for the LAP-Hsp60 interaction during Listeria infection is unkno

266 he protein Scribble and its relatives in the LAP protein family provide a paradigm for this.

267 just upstream of the ATG start codon in the LAP varities, which might be the reason for the differen

268 f these, biopsies accounted for 29.9% of the LAP (7.3% of the OPEN, P<0.0001) and the incidence of LA

269 d Rubcn(-/-) mice to examine the role of the LAP pathway in mediating the UV-induced immunotolerant p

270 ice lacking any of several components of the LAP pathway show increased serum levels of inflammatory

271 al protein Scribble (Scrib), a member of the LAP protein family, is essential for epithelial apicobas

272 resting tool to dissect the functions of the LAP* and LAP isoforms.

273 Furthermore, disruption of the LAP-A hexameric structure increased chaperone activity.

274 lin acetate binds to the LAP* but not to the LAP isoform, explaining why its inhibitory activity is s

275 nt with this, helenalin acetate binds to the LAP* but not to the LAP isoform, explaining why its inhi

276 rthermore, inhibition of TSP1 binding to the LAP/TGF-beta complex decreased fibrosis in engineered ex

277 he clinical response to treatment within the LAP cohort.

278 ls of this response were observed within the LAP group.

279 escued by the conserved "LU" region of these LAP proteins.

280 pecific ligation of 10-azidodecanoic acid to LAP in cells, in nearly quantitative yield after 30 min.

281 siRNAs were delivered to LAP-MYC mice, which develop hepatoblastoma, using lipid

282 In all, 486 patients were randomized to LAP (243) or OPEN (243), with 462 eligible for analysis

283 induced damage, it was shown that the tomato LAP-A and LAP-N and the Arabidopsis thaliana LAP1 and LA

284 Upon transplantation, LAP+ late gestation fetal hepatocytes formed hepatic, en

285 in pathway have clinical utility in treating LAP and other oral diseases associated with infection, i

286 nds TSP1, which could potentially limit TSP1-LAP association and subsequent TGF-beta activation.

287 PRRs, for reasons that are poorly understood LAP does not substantially contribute to Mtuberculosis c

288 estine lamina propria, where they upregulate LAP, downregulate IFN-gamma via ATF-3 expression and acq

289 Assays using LAP-A catalytic site mutants demonstrated that LAP-A cha

290 apoptotic germ cells by Sertoli cells using LAP.Although phagocytic clearance of apoptotic germ cell

291 The AUC of VAI, LAP and WHtR were all greater than 0.7, and the LAP was

292 The 2-year DFS was LAP 79.5% (95% confidence interval [CI] 74.4-84.9) and O

293 phagocytes, in particular macrophages, where LAP has instrumental roles in the clearance of extracell

294 culation on the putative mechanisms by which LAP may regulate immune function, perhaps through the me

295 systemic levels of endotoxin associated with LAP.

296 Through its association with LAP, TGF-beta is maintained in a latent form that must b

297 ree of systemic diseases, and diagnosed with LAP.

298 Fifty-nine individuals with LAP were treated by mechanical debridement and systemic

299 In primary neutrophils from persons with LAP, PDK1 expression and activation levels were signific

300 ) loads are lower in snowpacks enriched with LAPs and are attributed to reductions in snowpack albedo