ライフサイエンスコーパス: LBBB

1 LBBB and NICD patients had similar right ventricular tot

2 LBBB patients typically demonstrated (1) a single LV bre

3 LBBB was more frequent after implantation of the Medtron

4 LBBB, intraventricular conduction defect, and RBBB combi

5 LBBB-3 revealed more scar (2 [2-5] segments) compared wi

6 o heart failure patients (narrow QRS [n=18], LBBB [n=11], NICD [n=23]) underwent 3-dimensional electr

7 -1=double-peaked systolic shortening (n=28); LBBB-2=early systolic shortening followed by prominent s

8 al of 111 patients with DCM, 51 with CAD (29 LBBB), and 60 without CAD (30 LBBB) were studied with ec

9 1 with CAD (29 LBBB), and 60 without CAD (30 LBBB) were studied with echocardiography and cardiopulmo

10 In 52 of 66 LBBB VTs, the origin was from the RV perivalvular region

11 recordings were analyzed in 85 patients: 72 LBBB block pattern and 16 controls (narrow QRS, n=11; ri

12 transient or absent) LBBB after TAVI with a balloon-expandable valve and its

13 ents were performed in 22 dogs, 9 with acute LBBB, 7 with chronic LBBB combined with infarction (embo

14 % ]; P=0.009) increase than BiV-Opt, against LBBB as reference; BiV-Opt and biventricular pacing at A

15 Not all LBBB-morphology EIVA can be dismissed, and not all RBBB-

16 (2 [2-5] segments) compared with LBBB-1 and LBBB-2 (both 0 [0-1], P<0.05).

17 ss I or II and ejection fraction </= 30% and LBBB derive substantial clinical benefit from CRT-D: a r

18 by prominent systolic stretching (n=34); and LBBB-3=pseudonormal shortening with less pronounced late

19 rvedilol was seen in patients with CRT-D and LBBB.

20 and calcium concentration under healthy and LBBB conditions.

21 In LBBB and LBBB+HF animals, endocardial conduction was approximatel

22 all discriminate effectively between LLk and LBBB populations.

23 well they discriminated between the LLk and LBBB populations.

24 T-D, and those with a QRSD 150 to 179 ms and LBBB had only a modest improvement.

25 e achieved for patients with normal QRSd and LBBB during biventricular and LV pacing.

26 t may differentiate outcomes beyond QRSd and LBBB.

27 as an independent predictor in both RBBB and LBBB and, in addition, in LBBB, QRS/STT angle and ST J-p

28 ection fraction was similar between RBBB and LBBB patients (24.9% vs. 25.0%; p = 0.98); however, RBBB

29 with a suspected acute coronary syndrome and LBBB for urgent reperfusion therapy.

30 Compared with women with no BBB, LBBB, and intraventricular conduction defect were strong

31 nto left, right, and indetermined-type BBBs (LBBB, RBBB, and intraventricular conduction defect, resp

32 eath was not significantly different between LBBB patients with or without history of IAT (HR: 0.50,

33 entified CRT subgroups with relevance beyond LBBB and QRSd.

34 mong patients with left bundle branch block (LBBB) (hazard ratio [HR]: 0.58; p < 0.001) and no signif

35 RT-D patients with left bundle branch block (LBBB) (HR: 0.51 [95% CI: 0.35 to 0.76], p < 0.001).

36 pact of persistent left bundle-branch block (LBBB) after surgical aortic valve replacement.

37 tudy patients with left bundle branch block (LBBB) and 0, 1, 2, or >/=3 comorbidities, including rena

38 Of these, 1175 had left bundle-branch block (LBBB) and 308 had non-LBBB.

39 erized by isolated left bundle branch block (LBBB) and a history of progressive left ventricular (LV)

40 etween that during left bundle branch block (LBBB) and LV pacing, reflects optimal resynchronization,

41 ween patients with left bundle-branch block (LBBB) and normal QRSd and if synchrony improved during p

42 mpact of new-onset left bundle branch block (LBBB) and permanent pacemaker implantation (PPI) after t

43 that patients with left bundle branch block (LBBB) be treated with cardiac resynchronization therapy

44 Left bundle branch block (LBBB) causes left ventricular (LV) dyssynchrony which is

45 patients with non-left bundle branch block (LBBB) conduction abnormality have not been fully explore

46 ) patients without left bundle branch block (LBBB) did not derive a significant reduction in risk of

47 RT-D patients with left bundle branch block (LBBB) enrolled in MADIT-CRT (Multicenter Automatic Defib

48 w-onset persistent left bundle branch block (LBBB) in patients undergoing transcatheter aortic valve

49 t arrhythmias with left bundle-branch block (LBBB) morphology.

50 mong patients with left bundle-branch block (LBBB) or longer QRS duration.

51 Patients without left bundle branch block (LBBB) or patients with smaller QRS duration (QRSd) respo

52 ger scar size than left bundle branch block (LBBB) patients do.

53 n in patients with left bundle-branch block (LBBB) patterns has not been described previously.

54 onary syndrome and left bundle branch block (LBBB) present a unique diagnostic and therapeutic challe

55 n patients without left bundle branch block (LBBB) regardless of patient sex.

56 hearts with acute left bundle branch block (LBBB) showed that endocardial left ventricular (LV) paci

57 cardiac effects of left bundle-branch block (LBBB) using myocardial contrast echocardiography (MCE) t

58 ery wide QRSD with left bundle branch block (LBBB) versus those without LBBB.

59 Left bundle branch block (LBBB) was present in 65 patients, right bundle branch bl

60 re 1281 (70%) with left bundle-branch block (LBBB), 228 (13%) with right bundle-branch block, and 308

61 hic morphology was left bundle branch block (LBBB), and in 15, it was nonspecific intraventricular co

62 ar, the effects of left bundle branch block (LBBB), coronary artery disease (CAD), and total isovolum

63 t to patients with left bundle branch block (LBBB), heart failure patients with narrow QRS and nonspe

64 tients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear.

65 mong patients with left bundle branch block (LBBB), women had a 21% lower mortality risk than men (HR

66 py candidates with left bundle branch block (LBBB)-like electrocardiogram morphology (left ventricula

67 tion, (2) multiple left bundle-branch block (LBBB)-type VTs, and (3) an abnormal endocardial substrat

68 an heart, and with left bundle branch block (LBBB).

69 5% of subjects had left bundle-branch block (LBBB).

70 and patients with left bundle branch block (LBBB).

71 ight (RBBB) versus left bundle branch block (LBBB).

72 her complicated by left bundle-branch block (LBBB).

73 ective labeling of left bundle branch block (LBBB).

74 c HF patients with left bundle branch block (LBBB).

75 ed dogs with acute left bundle-branch block (LBBB, n=10) and chronic LBBB with tachypacing-induced he

76 patients with non-left bundle branch block (LBBB; including right bundle branch block, intraventricu

77 tion 26+/-7%) with left bundle-branch block (LBBB; QRS duration 174+/-18 ms) were atriobiventricularl

78 2.73 [95% CI, 1.78 to 4.13]; P < 0.001), but LBBB-morphology EIVA was not (hazard ratio, 0.82 [CI, 0.

79 The t-IVT, CAD, LBBB, and QRS duration were univariate predictors of exe

80 ntional epicardial CRT in compromised canine LBBB hearts.

81 s optimal timing of LV stimulation in canine LBBB hearts.

82 bundle-branch block (LBBB, n=10) and chronic LBBB with tachypacing-induced heart failure (LBBB+HF, n=

83 d concentric remodeling), and 6 with chronic LBBB and heart failure (rapid pacing, LBBB+HF, and eccen

84 n 22 dogs, 9 with acute LBBB, 7 with chronic LBBB combined with infarction (embolization; LBBB plus m

85 locity and pressure, with native conduction (LBBB) and during biventricular pacing at atrioventricula

86 In contrast, LBBB is most commonly caused by nonischemic pathologies.

87 after TAVI is higher in patients who develop LBBB than in patients who do not.

88 %) developed RBBB, but no patients developed LBBB.

89 er reason, then categorized as having either LBBB or no LBBB and QRS duration of either 150 ms or gre

90 LBBB combined with infarction (embolization; LBBB plus myocardial infarction, and concentric remodeli

91 LBBB with tachypacing-induced heart failure (LBBB+HF, n=6).

92 ] index: 0.80 +/- 0.03 vs. 0.58 +/- 0.09 for LBBB, p < 0.04; CURE 0-->1 is dyssynchronous-->synchrono

93 dian difference in CURE-SVD (range, 0-1) for LBBB-HF group versus narrow-QRS-HF group (-0.40; 95% con

94 io, 3.79; confidence interval, 2.95-4.87 for LBBB and hazard ratio, 3.53; confidence interval, 2.14-5

95 al deformation pattern is characteristic for LBBB and results from intraventricular dyssynchrony.

96 ECG criteria for LBBB incompletely predicted CCB, and intracardiac data m

97 inical composite score improved with CRT for LBBB subjects (odds ratio, 0.530; P=0.0034) but not for

98 at AV delays of 40 ms was no different from LBBB.

99 ad LBBB and a QRSd >/=150 ms, 85 (17.1%) had LBBB and QRSd <150 ms, 92 (18.5%) had non-LBBB and a QRS

100 were included in the study; 216 (43.5%) had LBBB and a QRSd >/=150 ms, 85 (17.1%) had LBBB and QRSd

101 On the other hand, LBBB was associated with a higher short-term rate of pac

102 How LBBB-related effects on LV diastolic function may contri

103 septal deformation patterns were identified: LBBB-1=double-peaked systolic shortening (n=28); LBBB-2=

104 In LBBB and LBBB+HF animals, endocardial conduction was app

105 V pacing reduced QRS duration by 21+/-10% in LBBB but only by 5+/-12% in LBBB+HF hearts.

106 n by 21+/-10% in LBBB but only by 5+/-12% in LBBB+HF hearts.

107 r in both RBBB and LBBB and, in addition, in LBBB, QRS/STT angle and ST J-point depression in aVL wer

108 Long-term survival was better in LBBB patients with QRSd >/=150 ms (p = 0.02), but this d

109 tion >/= 140 ms may warrant consideration in LBBB as an indication for further diagnostic evaluation

110 -CRT study, the clinical benefit of CRT-D in LBBB patients was not attenuated by prior history of IAT

111 increase in ejection fraction with CRT-D in LBBB than in non-LBBB patients.

112 ctor (P=0.006) of SPECT perfusion defects in LBBB patients without CAD.

113 Additionally, longer QRS duration in LBBB is associated with better survival in both sexes.

114 rker of diastolic mechanical dyssynchrony in LBBB hearts.

115 ICD) were significantly (P < 0.001) lower in LBBB patients (0.47; P < 0.001) than in non-LBBB patient

116 Mortality in LBBB and QRS of 150 ms or longer compared with those wit

117 independent predictor of incident HF only in LBBB, with more pronounced risk at QRS >/= 140 ms than a

118 chronization therapy were most pronounced in LBBB-1 and worst in LBBB-3 patients.

119 and MBF reserve is homogeneously reduced in LBBB patients with left ventricular systolic dysfunction

120 pulse conduction was significantly slower in LBBB+HF than in LBBB hearts (67+/-9 versus 44+/-16 ms, r

121 was significantly slower in LBBB+HF than in LBBB hearts (67+/-9 versus 44+/-16 ms, respectively), an

122 Multivariate analysis revealed that in LBBB patients, CRT-D, compared with implantable cardiove

123 vasodilator MCE and SPECT were undertaken in LBBB patients.

124 were most pronounced in LBBB-1 and worst in LBBB-3 patients.

125 ors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; confidence interval [CI],

126 TAVI-induced LBBB is an independent predictor of mortality.

127 influence the mortality risk of TAVI-induced LBBB.

128 LV pacing with short AV delay and intrinsic LBBB activation accurately predicted the optimal AV dela

129 Isolated LBBB in animals causes cardiac remodeling due to mechani

130 Inclusion of patients with isolated LBBB-morphology EIVA, which often is idiopathic, may con

131 een patients who did and did not develop new LBBB.

132 prior conduction disturbances developed new LBBB following TAVI with a balloon-expandable valve, alt

133 total of 233 patients (34.3%) developed new LBBB.

134 mmend that patients with new or presumed new LBBB undergo early reperfusion therapy, data suggest tha

135 ; adjusted HR, 1.18 [99% CI, 1.10-1.26]), no LBBB and QRS duration of 150 ms or greater (45.7%; HR, 1

136 rd ratio [HR], 1.30 [99% CI, 1.18-1.42]), no LBBB and QRS duration of 150 ms or greater (30.7%; HR, 1

137 30.7%; HR, 1.34 [99% CI, 1.20-1.49]), and no LBBB and QRS duration of 120 to 149 ms (32.3%; HR, 1.52

138 45.7%; HR, 1.16 [99% CI, 1.08-1.26]), and no LBBB and QRS duration of 120 to 149 ms (49.6%; HR, 1.31

139 then categorized as having either LBBB or no LBBB and QRS duration of either 150 ms or greater or 120

140 LBBB and QRS duration less than 150 ms or no LBBB regardless of QRS duration, was associated with low

141 Non-LBBB patients (n=537; 30%) were divided into 2 groups ba

142 with LBBB and QRSd <150 ms (8 +/- 10%), non-LBBB and QRSd >/=150 ms (5 +/- 9%), and non-LBBB and QRS

143 In 11,505 non-LBBB CRT-eligible patients, after multivariable adjustme

144 , and dyslipidemia, and had more often a non-LBBB (left bundle branch block) wide QRS complex, and lo

145 benefit was observed in patients with a non-LBBB QRS pattern (right bundle-branch block or intravent

146 Among non-LBBB CRT-D-eligible patients, CRT-D implantation was ass

147 < 0.001) and no significant effect among non-LBBB patients (HR: 1.05; p = 0.82, p for the difference

148 CRT-D was significantly increased among non-LBBB patients (HR: 3.62; p = 0.002, p for the difference

149 -LBBB and QRSd >/=150 ms (5 +/- 9%), and non-LBBB and QRSd <150 ms (3 +/- 11%) (p < 0.0001).

150 The latter 2 groups were defined as non-LBBB groups.

151 ta support the use of CRT-D in MADIT-CRT non-LBBB patients with a prolonged PR interval.

152 odds ratio, 0.530; P=0.0034) but not for non-LBBB subjects (odds ratio, 0.724; P=0.21).

153 ad LBBB and QRSd <150 ms, 92 (18.5%) had non-LBBB and a QRSd >/=150 ms, and 103 (20.8%) had non-LBBB

154 nd a QRSd >/=150 ms, and 103 (20.8%) had non-LBBB and QRSd <150 ms.

155 t bundle-branch block (LBBB) and 308 had non-LBBB.

156 however, there was no sex difference in non-LBBB (HR: 0.95; 95% CI: 0.85 to 1.06; p = 0.37).

157 LBBB patients (0.47; P < 0.001) than in non-LBBB patients (1.24; P = 0.257).

158 In non-LBBB patients with a normal PR interval, implantation of

159 In non-LBBB patients with a prolonged PR interval, CRT-D treatm

160 In non-LBBB patients with normal PR, CRT-D therapy was associat

161 y increase subsequent arrhythmic risk in non-LBBB patients.

162 y in CRT-D patients with LBBB but not in non-LBBB patients.

163 tion fraction with CRT-D in LBBB than in non-LBBB patients.

164 ients with LBBB with similar outcomes to non-LBBB patients (HR, 1.32 [95% CI, 0.93-1.62]; difference

165 ystolic volume index (P<0.0001), whereas non-LBBB patients had smaller decreases (6.7 mL/m(2); P=0.18

166 In patients with non-LBBB and QRS >/=160 ms, the hazard ratio for the primary

167 for CRT-D implantation in patients with non-LBBB conduction.

168 erter defibrillator-CRT in patients with non-LBBB, especially when the QRS duration is <160 ms.

169 sponse to CRT-D therapy in patients with non-LBBB.

170 oximal LAD occlusions should cause RBBB, not LBBB.

171 elf determined by the presence or absence of LBBB and CAD.

172 Assessment of LBBB contraction pattern was superior to time-to-peak in

173 le, we describe the evolving epidemiology of LBBB in acute coronary syndromes and discuss controversi

174 However, the existence of LBBB-induced cardiomyopathy in humans remains uncertain.

175 better than QRS duration or the presence of LBBB.

176 h acute myocardial infarction, regardless of LBBB chronicity, and that a significant proportion of pa

177 50.5 years of age on average at the time of LBBB diagnosis.

178 or the evaluation of the impact of new-onset LBBB and periprocedural PPI post-TAVR were sourced, resp

179 It is unclear whether new-onset LBBB may also impact the prognosis of patients after tra

180 all-cause 1-year mortality and (2) new-onset LBBB on the need for PPI at 1-year follow-up.

181 e the impact of (1) periprocedural new-onset LBBB or PPI post-TAVR on cardiac mortality and all-cause

182 for studies reporting raw data on new-onset LBBB post-TAVR and the need for PPI or mortality at 1-ye

183 New-onset LBBB post-TAVR is a marker of an increased risk of cardi

184 New-onset LBBB post-TAVR was associated with a higher risk of PPI

185 New-onset LBBB was observed in 61 patients (30.2%) after TAVI, and

186 New-onset LBBB was the only factor associated with PPI following T

187 roximal LAD septal perforator caused RBBB or LBBB.

188 hronic LBBB and heart failure (rapid pacing, LBBB+HF, and eccentric remodeling).

189 ft ventricular free wall resulted in pattern LBBB-1.

190 This transformed into pattern LBBB-2 by additionally simulating septal hypocontractili

191 g septal hypocontractility, and into pattern LBBB-3 by imposing additional left ventricular free wall

192 Persistent LBBB at hospital discharge was associated with a decreas

193 ents (group A; 27.4%) developed a persistent LBBB and the remaining 594 (group B; 72.6%) did not.

194 registry of high-volume centers, persistent LBBB after CoreValve Revalving System transcatheter aort

195 associated with a higher rate of persistent LBBB, which in turn determined higher risks for complete

196 7) were independent predictors of persistent LBBB.

197 Patients with persistent LBBB and no PPI at hospital discharge had a higher incid

198 ing CRT-D implantation in clinical practice, LBBB and QRS duration of 150 ms or greater, compared wit

199 tion were compared among patients with RBBB, LBBB, nonspecific LV conduction delay, and QRS <120 ms.

200 nefit was larger in concentrically remodeled LBBB plus myocardial infarction than in eccentrically re

201 l infarction than in eccentrically remodeled LBBB+HF hearts (19% versus 10%).

202 rvations support the existence of a specific LBBB-induced cardiomyopathy resolved by CRT.

203 Use of strict LBBB ECG criteria was not independently associated with

204 uction was observed in patients with surface LBBB pattern, ranging from no discrete block to CCB.

205 Sixty-three symptomatic LBBB patients (group A), 10 left ventricular ejection fr

206 hanical dyssynchrony is induced by RBBB than LBBB in failing hearts, and the corresponding impact of

207 ted with significantly larger scar size than LBBB is, and occlusion of a proximal LAD septal perforat

208 REVERSE demonstrated that LBBB and QRS prolongation are markers of reverse remodel

209 stationary or moving, and we also find that LBBB will cause the left ventricle to contract later tha

210 yses and inherent log-rank tests showed that LBBB was not associated with higher all-cause mortality,

211 rams from the LV free wall were later in the LBBB patients in absolute terms (155 ms [SD 23] versus 6

212 In contrast to LBBB patients, narrow QRS and NICD patients are characte

213 ersistent ST-segment elevation as opposed to LBBB or Q waves.

214 Most data pertain to LBBB delays.

215 rain echocardiography (2DSE) may detect true LBBB activation.

216 traction pattern assessment to identify true LBBB activation provided important prognostic informatio

217 Two-thirds of patients (63%) had a typical LBBB contraction pattern.

218 Absence of a typical LBBB contraction was independently associated with incre

219 investigate whether the absence of a typical LBBB mechanical activation pattern by 2DSE was associate

220 d syndrome, including: 1) history of typical LBBB for >5 years; 2) LV ejection fraction (EF) >50%; 3)

221 al 4-chamber view determined whether typical LBBB contraction was present.

222 B, 5+/-2 versus 1+/-1; P=0.0004; NICD versus LBBB, 4+/-2 versus 1+/-1; P=0.001); (2) evidence of earl

223 ior or anterior fascicles: narrow QRS versus LBBB, 5+/-2 versus 1+/-1; P=0.0004; NICD versus LBBB, 4+

224 chrony and impact of CRT in pure RBBB versus LBBB remains largely unknown.

225 90% sensitivity and 82% specificity whether LBBB was present or not.

226 (16 with LBBB), and 25 without CAD (10 with LBBB) were studied.

227 d with resynchronization pacemakers, 13 with LBBB (mean QRS, 171 ms) and 9 with normal QRSd <120 ms (

228 hree patients with DCM, 48 with CAD (16 with LBBB), and 25 without CAD (10 with LBBB) were studied.

229 duration of 150 ms or greater, compared with LBBB and QRS duration less than 150 ms or no LBBB regard

230 of 150 ms or greater (20.9%), compared with LBBB and QRS duration of 120 to 149 ms (26.5%; adjusted

231 of 150 ms or greater (38.6%), compared with LBBB and QRS duration of 120 to 149 ms (44.8%; adjusted

232 Those with RBBB (compared with LBBB) were more likely to have ischemic heart disease (7

233 d more scar (2 [2-5] segments) compared with LBBB-1 and LBBB-2 (both 0 [0-1], P<0.05).

234 In comparison with LBBB, biventricular pacing at separately preidentified h

235 In 24 canine hearts with LBBB (12 acute, 6 with heart failure, and 6 with myocard

236 At rest, t-IVT was 8 s/min longer with LBBB (p < 0.001), was unaffected by CAD, and did not cor

237 raction </=35%, QRS duration >/=120 ms) with LBBB by ECG were prospectively included.

238 mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) in patients without LBBB (P=0.002

239 CRT-D patients with LBBB and complete left-sided reverse remodeling had a si

240 ar synchrony) was observed for patients with LBBB and normal QRSd.

241 ar mortality were lowest among patients with LBBB and QRS duration of 150 ms or greater (20.9%), comp

242 mission were also lowest among patients with LBBB and QRS duration of 150 ms or greater (38.6%), comp

243 ection fraction) was better in patients with LBBB and QRSd >/=150 ms (12 +/- 12%) than in those with

244 uggest that only a minority of patients with LBBB are ultimately diagnosed with acute myocardial infa

245 creased significantly in CRT-D patients with LBBB but not in non-LBBB patients.

246 low direction in heart failure patients with LBBB compared to those without LBBB during early but not

247 tal activation time (LVTAT) in patients with LBBB compared with heterogeneous activation sequences an

248 IAT during follow-up in 1,264 patients with LBBB enrolled in the MADIT-CRT (Multicenter Automatic De

249 Patients with LBBB experienced a 25.3-mL/m(2) mean reduction in left v

250 were acquired in heart failure patients with LBBB or matched patients without LBBB.

251 rrected wide QRS in 54% of all patients with LBBB pattern and 85% of those with CCB (94% left intrahi

252 ctrode catheter in consecutive patients with LBBB pattern referred for device implantation (n=38) or

253 m follow-up of MADIT-CRT study patients with LBBB randomized to CRT-D, there were differences in HF o

254 In patients with LBBB receiving implantable cardioverter defibrillator-CR

255 ts with narrow QRS and NICD to patients with LBBB using high-density electroanatomic activation maps.

256 Patients with LBBB were less likely to experience at least one VT/VF e

257 proach among clinically stable patients with LBBB who do not have electrocardiographic findings highl

258 Patients with LBBB who experienced a first VTE had no change in the ri

259 Among patients with LBBB who received CRT-D, mortality is lower in women tha

260 8+/-9.7%; P<0.001), even among patients with LBBB with QRSd >=150 ms (HR, 0.42 [95% CI, 0.30-0.57]; P

261 ms with comparable outcomes to patients with LBBB with QRSd >=150 ms (HR, 0.93 [95% CI, 0.67-1.29]; d

262 ication scheme also identified patients with LBBB with QRSd <150 ms with comparable outcomes to patie

263 a and QRS PCA group identified patients with LBBB with similar outcomes to non-LBBB patients (HR, 1.3

264 population comprised 533 CRT-D patients with LBBB, 212 (40%) with complete left-sided reverse remodel

265 ts with LLk and 72 consecutive patients with LBBB, all without prior myocardial infarction or sternot

266 In patients with LBBB, there was a continuous relationship between broade

267 Among patients with LBBB, women receiving CRT-D had a lower relative death r

268 Patients with LBBB-morphology EIVAs had a mortality rate (2.5%) simila

269 ated with better survival in both sexes with LBBB and QRS >/=130 ms, whereas there was no clear relat

270 th a lower mortality risk in both sexes with LBBB, although more pronounced among women.

271 ated with better survival in both sexes with LBBB, but not in patients without LBBB.

272 s effect on hearts with RBBB than those with LBBB (i.e., 5.5 +/- 1.1% vs. 29.5 +/- 5.0% increase in d

273 ith an improvement in survival in those with LBBB and a QRSD >/=180 ms (adjusted HR for death: 0.78;

274 95% CI: 0.68 to 0.91), but not in those with LBBB and a QRSD 150 to 179 ms (adjusted HR for death: 1.

275 of 150 ms or longer compared with those with LBBB and QRS of 120 to 129 ms was similar between sexes

276 Sd >/=150 ms (12 +/- 12%) than in those with LBBB and QRSd <150 ms (8 +/- 10%), non-LBBB and QRSd >/=

277 Only among those with LBBB, both sexes had better survival with longer QRS dur

278 Among those with LBBB, patients with a QRSD >/=180 ms had a greater adjus

279 Compared with women with LBBB and QRS of 120 to 129 ms, women with LBBB and QRS o

280 th LBBB and QRS of 120 to 129 ms, women with LBBB and QRS of 140 to 149 ms had a 27% lower mortality

281 s patients with a QRSD 150 to 179 ms without LBBB had no improvement in survival with CRT-D, and thos

282 tients with a QRSD >/=180 ms with or without LBBB, whereas patients with a QRSD 150 to 179 ms without

283 MSI for detecting CAD in DCM with or without LBBB.

284 h LBBB and 24.0% (n=107) in patients without LBBB (P=0.002).

285 ile range, 253-725) days in patients without LBBB (P=0.90).

286 rm risk of recurrent HHF in patients without LBBB in MADIT-CRT.

287 RS duration and survival in patients without LBBB regardless of patient sex.

288 neficial effect of CRT-D in patients without LBBB subsequent to development of a first HHF, possibly

289 he mortality differences in patients without LBBB were attenuated in both sexes.

290 Patients without LBBB with >=1 HHF during the first year of follow-up dem

291 ere is no sex difference in patients without LBBB, regardless of QRS duration.

292 Among patients without LBBB, the benefit of CRT-D was nonsignificant for the fi

293 th p < 0.001) compared with patients without LBBB.

294 tients with LBBB or matched patients without LBBB.

295 sexes with LBBB, but not in patients without LBBB.

296 on fraction-matched control subjects without LBBB and no CAD (group B), and 10 normal control subject

297 patients with LBBB compared to those without LBBB during early but not late diastole.

298 centers in Italy, we analyzed those without LBBB or pacemaker at admission (879 patients [82.9%]).

299 In those without LBBB, the mortality difference was modest and did not di

300 dle branch block (LBBB) versus those without LBBB.