ライフサイエンスコーパス: LIP

1 LIP Fano factor changes are behaviorally significant: in

2 LIP has been associated with the development of inflamma

3 LIP neurons have recently been reported to inaccurately

4 LIP responses during fixation are thought to represent a

5 LIP responses recapitulated MT early weighting and conta

6 LIP ultrasound treatment was performed daily with triple

7 LIP up-regulated the transcription of CXCR4 through dire

8 LIP-pursuit correlations were spatially specific and wer

9 deficiencies in the 45RAGKO mice that affect LIP.

10 f the indigenous microbiota protects against LIP-induced osteonecrosis.

11 inear bottom-up integrative mechanisms allow LIP neurons to emphasize task-relevant spatial and non-s

12 Although LIP inactivation did not impair psychophysical behaviour

13 w that any existing algorithm for solving an LIP can be integrated into the PRP framework and used to

14 o our knowledge-that tumor sensitivity to an LIP-targeted therapy can be predicted with a molecular i

15 presenting instantaneous motion evidence and LIP reflecting the accumulated evidence.

16 %SAT, circulating hepcidin, and LIP in macrophages correlate with disease severity and %

17 ding three protein isoforms--LAP1, LAP2, and LIP.

18 In groups LIP and LIP/PROB, the mandibular right first molar of the animal

19 mation is directed to parietal areas MIP and LIP during decision formation.

20 tant deviations from idealizations of MT and LIP and motivate inquiry into sensorimotor computations

21 lyses of the simultaneous activity of MT and LIP during individual decisions.

22 mputations that may intervene between MT and LIP.

23 In groups PROB and LIP/PROB, the PROB was administered orally by addition t

24 nto four groups: control (C), LIP, PROB, and LIP/PROB.

25 show that salience--measured in saccades and LIP responses--was enhanced by both novelty and positive

26 Area LIP neurons that do not fire coherently do not predict R

27 d signals in posterior parietal cortex (area LIP).

28 Neuronal recordings from area LIP revealed two main findings.

29 ed the discharge activity of neurons in area LIP and the parietal reach region (PRR) of the parietal

30 Neurons in area LIP exhibited firing rate patterns that directly resembl

31 idence that eye-position gain fields in area LIP remain spatially inaccurate for some time after a sa

32 cortex (including lateral intraparietal area LIP) neurons while monkeys learned 7-item transitive inf

33 ss-adaptation may occur in a homolog of area LIP.

34 h, we identify a population of parietal area LIP neurons that fire spikes coherently with 15 Hz beta-

35 Although the lateral intraparietal area (LIP) and frontal eye field (FEF) are known to represent

36 , neurons in the lateral intraparietal area (LIP) and the frontal eye fields (FEF) exhibit persistent

37 in fields in the lateral intraparietal area (LIP) are unreliable.

38 e neurons in the lateral intraparietal area (LIP) exhibit anticipatory remapping: these neurons produ

39 The lateral intraparietal area (LIP) has been implicated as a salience map for control o

40 its, the primate lateral intraparietal area (LIP) has been interpreted as a priority map for saccades

41 responses in the lateral intraparietal area (LIP) have received extensive study for insight into deci

42 (dlPFC) and the lateral intraparietal area (LIP) in monkeys using a memory saccade task in which a s

43 The lateral intraparietal area (LIP) in the macaque contains a priority-based representa

44 ce in the monkey lateral intraparietal area (LIP) in ways that are independent of expected reward.

45 othesis that the lateral intraparietal area (LIP) integrates disparate task-relevant visual features

46 The lateral intraparietal area (LIP) is essential for this process.

47 t neurons in the lateral intraparietal area (LIP) of Macaca mulatta reflect learned associations betw

48 ields (FEFs) and lateral intraparietal area (LIP) of macaques are preferentially activated by saccade

49 ggested that the lateral intraparietal area (LIP) of macaques plays a fundamental role in sensorimoto

50 f neurons in the lateral intraparietal area (LIP) of rhesus monkeys performing this task.

51 ivity in macaque lateral intraparietal area (LIP) provides a useful window into this process.

52 , neurons in the lateral intraparietal area (LIP) reflect learned associations between visual stimuli

53 f neurons in the lateral intraparietal area (LIP) reflected the accumulation of logLR and reached a s

54 , neurons in the lateral intraparietal area (LIP) represent the accumulation of evidence bearing on t

55 activity in the lateral intraparietal area (LIP) represents the gradual accumulation of evidence tow

56 ecordings in the lateral intraparietal area (LIP) reveal that parietal cortex encodes variables relat

57 neurons from the lateral intraparietal area (LIP), a cortical node in the NHP saccade system.

58 eye field (FEF), lateral intraparietal area (LIP), and cuneus support early covert targeting of the c

59 ye fields (FEF), lateral intraparietal area (LIP), and pulvinar.

60 ordings from the lateral intraparietal area (LIP), during a perceptual decision-making task.

61 ral cortex (IT), lateral intraparietal area (LIP), prefrontal cortex (PFC), and frontal eye fields (F

62 e neurons in the lateral intraparietal area (LIP), which has been implicated in the planning and exec

63 activity in the lateral intraparietal area (LIP), which is thought to represent the relative value o

64 ctivation of the lateral intraparietal area (LIP), which plays a role in the selection of eye movemen

65 decisions in the lateral intraparietal area (LIP).

66 entations in the lateral intraparietal area (LIP).

67 y of the primate lateral intraparietal area (LIP).

68 parietal sulcus [lateral intraparietal area (LIP)] specifically biased choices made using eye movemen

69 al cortex [human lateral intraparietal area (LIP)], the anterior cingulate cortex (ACC) was specifica

70 the lateral and ventral intraparietal areas (LIP; VIP), the middle temporal area (MT), and the medial

71 rtical hierarchy (sensory (V4), association (LIP), motor and other areas) proposing the HR as an elem

72 Because LIP cells are (1) highly responsive to the presence of a

73 xtrinsic saliency are signaled in FEF before LIP.

74 A significant positive correlation between LIP and CXCR4 expression was observed in stage III and I

75 long-timescale recurrent excitation between LIP and FEF.

76 escribe dynamic temporal hierarchies between LIP and FEF: stimuli carrying the highest intrinsic sali

77 However, this link between LIP response and decision formation emerged from studies

78 Here, we focus on the relationship between LIP responses and known sensory and motor events in perc

79 dependent innate lymphoid cells (ILCs) block LIP of CD8(+) T cells in neonatal but not adult mice.

80 eously recorded ensembles of neurons in both LIP and FEF while macaques performed a memory-guided sac

81 ne with previous studies, we found that both LIP and PRR encode a reward-based decision variable, the

82 ex (human 7a), which has connections to both LIP and ACC, was activated by surprise and modulated by

83 cluding their variability, were explained by LIP activity in the context of accumulation of logLR to

84 l intestine from reactive changes induced by LIP.

85 e highest intrinsic saliency are signaled by LIP before FEF, whereas stimuli carrying the highest ext

86 domly divided into four groups: control (C), LIP, PROB, and LIP/PROB.

87 interplay between physiology and cognition, LIP has served as fertile ground for developing quantita

88 e roles of other parietal areas by comparing LIP and the medial intraparietal area (MIP) during a vis

89 Herein we review factors controlling LIP, including coinhibitory molecules and other attenuat

90 l, such as the lateral intraparietal cortex (LIP), the frontal eye fields (FEF), and the superior col

91 ions are distributed across parietal cortex, LIP and MIP play distinct roles: LIP appears more involv

92 stent with the relative (18)F-TRX-determined LIP levels in tumors before therapy.

93 f late expression, and upon differentiation, LIP levels are significantly reduced, allowing LAP-media

94 elds (RFs), dynamics of the high-dimensional LIP network during slowly varying activity lie predomina

95 ease-predisposing cofactor is present during LIP.

96 C/EBPbeta-LIP also disrupts Rb-E2F1 complexes in C/EBPalpha-S193D

97 se of a dominant negative isoform, C/EBPbeta-LIP, and subsequent repression of C/EBPalpha, FXR, and T

98 rotein isoforms C/EBPalpha-p30 and C/EBPbeta-LIP, which is controlled by a single cis-regulatory upst

99 identify those tumors with the most elevated LIP and thus most likely to succumb to LIP-targeted inte

100 drug payloads) and molecules that exacerbate LIP-induced oxidative stress to trigger ferroptosis.

101 ranged from LIP volcanism (the Karoo-Ferrar LIP), ocean stagnation, and changing ocean circulation,

102 Our petrological model for LIP magmatism argues that initial gas emission was domin

103 A negative-binomial model for LIP spike counts captures these findings quantitatively,

104 represent a novel costimulatory pathway for LIP.

105 which they made saccades toward or away from LIP response fields (RFs).

106 s of the late Pliensbachian have ranged from LIP volcanism (the Karoo-Ferrar LIP), ocean stagnation,

107 We recorded from LIP neurons during performance of a task that required m

108 To test this, we recorded from LIP while monkeys performed a motion discrimination task

109 k-relevant visual features by recording from LIP neurons in monkeys trained to identify target stimul

110 ignificantly higher than the ones from group LIP (VH: 672.1 +/- 83.3 microm and 528.0 +/- 51.7 microm

111 L and ABL were significantly higher in group LIP compared with group LIP/PROB (AL: 3.05 +/- 0.57 mm a

112 In group LIP/PROB, the mean values of VH and CD of the jejunum we

113 ntly higher in group LIP compared with group LIP/PROB (AL: 3.05 +/- 0.57 mm and 1.78 +/- 0.63 mm, res

114 In groups LIP and LIP/PROB, the mandibular right first molar of th

115 d relative to macaque monkeys, so that human LIP paradoxically ends up medial to human VIP.

116 Both F5 and OT-I LIP responses were most accurately described by a single

117 Effectively implementing LIP-targeted therapies in patients will require biomarke

118 e recorded single neuron spiking activity in LIP during a well-studied moving-dot direction-discrimin

119 We propose that activity in LIP represents attentional priority and that the downstr

120 Test-period activity in LIP showed category encoding and distinguished between m

121 We examined the neural code in LIP at the level of individual spike trains using a stat

122 ally, the target desirability was encoded in LIP at least twice as strongly when choices were made us

123 pected, we found strong category encoding in LIP.

124 relevant spatial and non-spatial features in LIP remain unclear.

125 psychophysical performance, inactivation in LIP had no measurable impact on decision-making performa

126 spatial signals are encoded independently in LIP and underscores the role of parietal cortex in nonsp

127 onger and appeared with a shorter latency in LIP than MIP.

128 Neurons in LIP exhibit ramping trial-averaged responses during deci

129 l connectivity than FEF, and many neurons in LIP had longer network and intrinsic timescales.

130 dea that value-based decisions take place in LIP neurons.

131 Alpha/beta power in LIP, FEF, and PFC inhibited spiking in deep layers of V4

132 strong evidence for retinotopic remapping in LIP and face-centered remapping in VIP, and weaker evide

133 The polar angle representation in LIP extends from regions near the upper vertical meridia

134 d understanding of neural representations in LIP and a framework for studying the coding of multiplex

135 he flexibility of feature representations in LIP reflect the bottom-up integration of sensory signals

136 In sum, neural responses in LIP simultaneously carry decision signals and decision-i

137 We examined single-trial responses in LIP using statistical methods for fitting and comparing

138 ink the encoding of saccades and saliency in LIP to modulation of several other sensory-motor behavio

139 Thus, decision-related signals in LIP do not appear to be critical for computing perceptua

140 fluence robustly encoded category signals in LIP.

141 Furthermore, trial-by-trial variability in LIP did not depend on MT activity.

142 We reversibly inactivated LIP while monkeys performed memory-guided saccades and r

143 cer cells, and this coincided with increased LIP binding on the CXCR4 promoter.

144 Individual LIP neurons might encode associations only for specific

145 d that optimal decoding requires integrating LIP spikes over two distinct timescales.

146 Intracellular LIP indices were significantly elevated in the subsets o

147 ibly inactivating the lateral intraparietal (LIP) and middle temporal (MT) areas of rhesus macaques p

148 ronal activity in the lateral intraparietal (LIP) area and PFC in monkeys performing a visual motion

149 atial encoding in the lateral intraparietal (LIP) area by training monkeys to perform a visual catego

150 eurons in the macaque lateral intraparietal (LIP) area exhibit firing rates that appear to ramp upwar

151 motor regions such as lateral intraparietal (LIP) area in perceptual decision making.

152 across neurons in the lateral intraparietal (LIP) area of the posterior parietal cortex.

153 dle temporal (MT) and lateral intraparietal (LIP) areas appear to map onto theoretically defined quan

154 neurons in the monkey lateral intraparietal (LIP) cortical area encode only cue salience, and not act

155 Lateral intraparietal (LIP) neurons encode a vast array of sensory and cognitiv

156 ccadic eye movements, lateral intraparietal (LIP) neurons representing each saccade fire at a rate pr

157 (visual area 4 [V4], lateral intraparietal [LIP], posterior parietal area 7A, frontal eye field [FEF

158 oform knockin DCs, whereas the short isoform LIP supported a differentiation program similar to delet

159 large isoform (LAP-2) and the small isoform (LIP) of C/EBP-beta can exert suppressive function for mi

160 The temporal relationship between the Karoo LIP and the late Pliensbachian (Kunae-Carlottense ammoni

161 d here show that causality between the Karoo LIP and the late Pliensbachian events cannot be maintain

162 higher brain fluorescence intensity and MAN-LIP relatively concentrated in the cerebellum and cerebr

163 onjugated onto the surface of liposomes (MAN-LIP) to enhance the brain delivery.

164 relationship between the distribution of MAN-LIP and glucose transporters (GLUTs) on the cells.

165 e investigated the brain distribution of MAN-LIP based on our previous studies and tried to explore t

166 osis by GLUT1 and GLUT3 was a pathway of MAN-LIP into brain, and the special brain distribution of MA

167 n, and the special brain distribution of MAN-LIP was closely related to the non-homogeneous distribut

168 ted that the transendothelial ability of MAN-LIP was much stronger when crossing LV-GLUT1/bEND.3 cell

169 metry showed that the cellular uptake of MAN-LIP was significantly improved by GLUT1 and GLUT3 overex

170 The mice administered with MAN-LIP had significantly higher brain fluorescence intensit

171 In many LIP neurons, there was a significant trial-by-trial corr

172 tal gyrus (SFG), middle frontal gyrus (MFG), LIP, anterior intraparietal sulcus (IPSa)] that may coor

173 Moreover, LIP activity is also strongly modulated by the position

174 Moreover, LIP ultrasound stimulation significantly improved learni

175 timal decoder for heterogeneous, multiplexed LIP responses that could be implemented in biologically

176 The conserved N-LIP and haloacid dehalogenase-like domains of Pah1 are r

177 we tested whether tumor uptake of the novel LIP-sensing radiotracer (18)F-TRX aligns with tumor sens

178 imotor-focused approach offers an account of LIP activity as a multiplexed amalgam of sensory, cognit

179 tional priority by examining the activity of LIP neurons while animals perform a visual foraging task

180 The beneficial effect of LIP ultrasound may be partly induced by upregulation of

181 Task-specific effects of LIP inactivation on blood oxygen level-dependent activit

182 f LIP ultrasound, neuroprotective effects of LIP ultrasound were evaluated with behavioral analysis,

183 g Bayesian inference from small ensembles of LIP neurons without the animal making an eye movement.

184 However, extraction of LIP teeth led to increased empty lacunae, necrotic bone,

185 thors failed to replicate basic hallmarks of LIP physiology observed in those subsequent temporal epo

186 al areas (especially the putative homolog of LIP) were more strongly labeled after 6DR injections.

187 ases in distractibility than inactivation of LIP.

188 This ILC-based inhibition of LIP ensures the generation of a diverse naive T cell poo

189 e processes have enriched interpretations of LIP activity.

190 In contrast with interpretations of LIP as providing an instantaneous code for decision vari

191 egrated with other lines of investigation of LIP function.

192 cue would either shift the initial level of LIP activity before sensory evidence arrived, or it woul

193 rated a clear shift in the activity level of LIP neurons following the arrow cue, which persisted int

194 The majority of LIP cells with steady-state gain fields reflect the pres

195 ne might expect that roughly even numbers of LIP neurons would prefer each set of associated stimuli.

196 d coordination mechanism, located outside of LIP, that actively delays reaches until shortly after th

197 e have no means to reconstruct the pacing of LIP greenhouse gas emissions for comparison with climate

198 rection from the responses of populations of LIP neurons.

199 ce were identified within dorsal portions of LIP with peripheral representations in ventral portions.

200 ariability can also improve the precision of LIP's priority map.

201 reviously showed that the mean spike rate of LIP neurons is strongly influenced by spatially wide-ran

202 -by-trial correlations of the firing rate of LIP neurons with the speed of "glissades" that occur at

203 We found that the firing rates of LIP neurons did not correlate well with the animals' beh

204 uestion, we compared the neural responses of LIP neurons in two subjects with their saccadic behavior

205 We also recorded from a broad sample of LIP neurons, including ones conventionally excluded in p

206 timulus, manifesting as a change in slope of LIP firing rates.

207 Here, we examine the specialization of LIP for categorization and the roles of other parietal a

208 odel accounts for the detailed statistics of LIP spike trains and accurately predicts spike trains fr

209 The structure of LIP population responses is therefore essential for reli

210 ending, the responses in almost one-third of LIP neurons closely resemble the responses that will eme

211 This has led to the view of LIP-driven autoimmunity as a two hit model; however, not

212 After 2 weeks of LIP ultrasound, neuroprotective effects of LIP ultrasoun

213 Reexpression of LAP1 but not LAP2 or LIP restores the ability of C/EBPbeta-deficient mammary

214 lutions to form the solution to the original LIP.

215 mentation on ligature-induced periodontitis (LIP) and intestinal morphology in rats.

216 presence of ligature-induced periodontitis (LIP).

217 nd temperature Te in a laser-induced plasma (LIP), using a model free of assumptions regarding local

218 ase of the intracellular labile Fe(II) pool (LIP).

219 ing the expanded cytosolic labile iron pool (LIP) of the cancer cell.

220 ometry for quantitation of labile iron pool (LIP) was performed.

221 ecies may constitute the "labile iron pool" (LIP) proposed in cellular Fe trafficking.

222 solve a large-scale linear inverse problem (LIP) is to retain computational efficiency and accuracy

223 enhancing lymphopenia-induced proliferation (LIP) in vivo, and that IL-18 synergizes with high-dose I

224 ult mice, lymphopenia-induced proliferation (LIP) leads to T cell activation, memory differentiation,

225 Lymphopenia-induced proliferation (LIP) occurs when resources for T cell survival in a host

226 show that lymphopenia-induced proliferation (LIP) of CD45-sufficient T cells is defective in a host e

227 deling of lymphopenia-induced proliferation (LIP) of two distinct T cell clonotypes.

228 nia with respect to the factors that promote LIP as a tool to predict autoimmune potential and to inf

229 while the liver-enriched inhibitory protein (LIP) isoform negatively regulates late expression.

230 , and the liver-enriched inhibitory protein (LIP) isoform of C/EBPbeta, but not the liver-enriched ac

231 with the liver-enriched inhibitory protein (LIP) region of C/EBPbeta.

232 /EBPbeta, liver-enriched inhibitory protein (LIP), as a previously unrecognized transcriptional regul

233 C/EBPbeta isoform, liver inhibitory protein (LIP).

234 426 Ma was part of a large igneous province (LIP) and represents a waning stage in the emplacement of

235 oprotective effects of low-intensity pulsed (LIP) ultrasound on memory impairment and central nervous

236 an intraparietal sulcus (IPS) area, putative LIP, participates in motor decisions.

237 OT-I T cells undergo rapid LIP accompanied by differentiation that superficially re

238 and both dorsal and ventral sensory regions [LIP, IPSa, ventral IPS, lateral occipital region, and fu

239 of the ACC and two parietal saccade regions, LIP and 7a, by which their involvement in diverse tasks

240 le parietal areas (e.g., the saccade-related LIP's).

241 Here, we report LIP and FEF neuronal activities recorded while monkeys p

242 tal cortex, LIP and MIP play distinct roles: LIP appears more involved in the categorization process

243 While [S]-PM and [S]-LIP possessed longer circulation half-lives, the three p

244 ymeric micelles ([S]-PM), and liposomes ([S]-LIP), that are loaded with the HMG-CoA reductase inhibit

245 e by plaque macrophages in comparison to [S]-LIP, while [S]-PM demonstrated the highest uptake by Ly6

246 involving the decomposition of a large-scale LIP into sub-problems of low complexity and the fusion o

247 tates of both Si and C, the example of a SiC LIP is taken to illustrate the consistency and accuracy

248 s demonstrate the low dimensionality of slow LIP local dynamics, and suggest that LIP local networks

249 s suppressed by stimuli outside the RF, slow LIP dynamics markedly deviate from a single dimension.

250 in a TRAF6-dependent manner to induce slow, LIP/homeostatic-like proliferation of naive CD8 T cells

251 cells were unable to rescue the spontaneous LIP in the 45RAGKO mice.

252 Conclusion These results suggest LIP ultrasound stimulation protects against brain injury

253 nding into the lateral intraparietal sulcus (LIP) was found.

254 ral recordings shows that, during DMC tasks, LIP and PFC neurons demonstrate mixed, time-varying, and

255 ated with the passage of time, we found that LIP activity decreased at a constant rate between timed

256 We found that LIP responses reflected a combination of temporally over

257 We found that LIP showed stronger, more reliable and shorter latency c

258 It is compatible neither with the idea that LIP neurons represent action value nor with the idea tha

259 This finding indicates that LIP neurons are sensitive to the motivational salience o

260 tion has been interpreted as indicating that LIP neurons encode saccadic value and that they mediate

261 We show that LIP neurons exhibit integrative representations of both

262 In this issue, Fitzgerald et al. show that LIP neurons in monkeys encode categorically distinct tas

263 Here, we show that LIP neurons representing a given saccade fire strongly n

264 These data suggest that LIP activity does not represent value in complex environ

265 These findings suggest that LIP and dlPFC mediate different aspects of selective att

266 These results suggest that LIP contributes to saccade planning but not to reach pla

267 We suggest that LIP is a component of a salience representation that mod

268 the selection of target-stimuli suggest that LIP is involved in transforming sensory information into

269 These findings suggest that LIP is strongly involved in visual categorization and ar

270 of slow LIP local dynamics, and suggest that LIP local networks encoding the attentional and movement

271 ct on decision-related encoding suggest that LIP plays a role in detecting target stimuli by comparin

272 This suggests that LIP activity encodes timed movements in a push-pull mann

273 This suggests that LIP plays a role in flexibly integrating task-relevant s

274 ed reward leads to lower variability for the LIP representation of both the target and distractor loc

275 However, if the LIP activity was further normalized, it became highly co

276 lutathionylation of Cys201 and Cys296 in the LIP region of C/EBPbeta.

277 The antitumor effects of the LIP-activated prodrug TRX-CBI, which releases the DNA al

278 Thus, the LIP Fano factor reflects both stimulus and behavioral en

279 ation of endosomes for Fe(II) release to the LIP likely through RapGEF2.

280 e art includes therapies that react with the LIP to produce cytotoxic radical species (in some cases

281 aling, with a focus on their contribution to LIP-driven autoimmunity.

282 ed with performance in the dlPFC relative to LIP.

283 r (18)F-TRX aligns with tumor sensitivity to LIP-targeted therapies.

284 vated LIP and thus most likely to succumb to LIP-targeted interventions.

285 ork sparked debate over whether single-trial LIP spike trains are better described by discrete "stepp

286 conflicting results can be reconciled if two LIP local networks, each underlying an RF location and d

287 owever, most neonatal T cells do not undergo LIP.

288 bles some recent thymic emigrants to undergo LIP and convert into long-lived memory T cells.

289 Unexpectedly, LIP exhibited stronger local functional connectivity tha

290 -related activity in parietal areas V6, V6A, LIP, and caudal intraparietal area and frontal areas FEF

291 Rather than viewing LIP-associated autoimmunity as an n-hit model, we sugges

292 found within LIP, referred to as visuotopic LIP.

293 ated activity was attenuated in MIP, whereas LIP neurons were active while monkeys communicated decis

294 To test this, we asked whether LIP neurons encode learned associations between pairs of

295 l cornu ammonis 1 region was alleviated with LIP ultrasound.

296 duces AL and alveolar bone loss in rats with LIP and 2) can protect the small intestine from reactive

297 antly greater in the BCCAO rats treated with LIP ultrasound than in the untreated BCCAO rats (mean, 9

298 accumulation in the BCCAO rats treated with LIP ultrasound was significantly (P < .05) increased by

299 factor (BDNF) in the BCCAO rats treated with LIP ultrasound were significantly higher than those in B

300 polar angle representation was found within LIP, referred to as visuotopic LIP.