ライフサイエンスコーパス: LPA receptor

1 finding demonstrates stereoselectivity by an LPA receptor.

2 the GenBankTM for homologs of the human Edg2 LPA receptor.

3 ndicate that Edg-2 encodes a highly specific LPA receptor.

4 it independent regulation of each subtype of LPA receptor.

5 opus that encodes a functional high-affinity LPA receptor.

6 gonucleotide did not affect the low-affinity LPA receptor.

7 ) receptor LPA1/Edg2 is the first identified LPA receptor.

8 KO mice of LPA(4), a Galpha(12/13)-coupling LPA receptor.

9 rphan receptor GPR92 has properties of a new LPA receptor.

10 protein-dependent pathways activated by the LPA receptor.

11 t difficult to assign a response to specific LPA receptors.

12 ve been identified that encode high-affinity LPA receptors.

13 distinct functions among the three mammalian LPA receptors.

14 new genes that may encode novel subtypes of LPA receptors.

15 hat functions as a mitogen by acting through LPA receptors.

16 ell-cell junctions through Galpha(i)-coupled LPA receptors.

17 in contrast to the motility-stimulating Edg LPA receptors.

18 g that beta-arrestin 2 may recruit CARMA3 to LPA receptors.

19 structurally distant from the canonical Edg LPA receptors.

20 t of endothelial differentiation gene family LPA receptors.

21 ional antagonism between the two subtypes of LPA receptors.

22 through the activation of G protein-coupled LPA receptors.

23 cells, were utilized and compared with known LPA receptors.

24 lso activates cellular targets distinct from LPA receptors.

25 downstream rho signaling by the thrombin and LPA receptors.

26 ired to interact with lysophosphatidic acid (LPA) receptors.

27 ) treatment drug Siponimod, as well as human LPA receptor 1 (LPA(1)) and G(i) complexes in the presen

28 SMCs derived from LPA receptor 1 (LPA1) knock-out mice lack the ability of

29 activation and pharmacological inhibition of LPA receptor 1 (LPAR1) abrogate cilia disassembly trigge

30 Pharmacological and genetic blockage of LPA receptor 1 (LPAR1) or autotoxin (ATX), a secretory l

31 Here, we demonstrate that through the LPA receptor 1 (LPAR1), serum lysophosphatidic acid (LPA

32 ry effect of G-3-P and LPA on FGF23 required LPA receptor 1 (LPAR1).

33 al angiomyolipomas have higher expression of LPA receptor 1 and S1P receptor 3 compared with normal k

34 phosphatidic acid (LPA), which activates the LPA receptor 1 in FGF23-secreting cells in the bone and

35 gr-1 expression is via LPA cognate receptor (LPA receptor 1)-dependent and PKCdelta-mediated ERK and

36 molecules, including autotaxin (ATX, Enpp2), LPA receptor 1/3 (LPA1/3), betaCaMKII, and c-Fos.

37 (hMCs) in vitro through a pathway involving LPA receptors 1 and 3 (termed the LPA(1) and LPA(3) rece

38 ously, we showed that lysophosphatidic acid (LPA) receptor 1 regulates proliferation of intestinal ep

39 The expression of LPA receptor 2 (LPA2) is up-regulated in several types o

40 rally restricted decrease in the mobility of LPA receptor 2 (LPA2) on chemotactic fibroblasts.

41 his study, we identify the G-protein-coupled LPA receptor 2 (LPAR2) as a signal transducer specifical

42 atidic acid (LPA) driving chemotaxis through LPA receptor 2 and actin cytoskeletal mobilization.

43 adherin downstream of lysophosphatidic acid (LPA) receptor 2.

44 nderlie these phenotypes because deletion of LPA receptor 4 in mice promotes early aortic dilation an

45 (LPA) regulates CD8 T-cell function through LPA receptor 5 (LPAR5) signaling, including demonstratin

46 However, whether different LPA receptors activate distinct anti-apoptotic signaling

47 AzoLPA enables optical control of LPA receptor activation, shown through its ability to ra

48 itive inhibitors of ATX, thereby attenuating LPA receptor activation.

49 tinct subset of ERK1/2-mediated responses to LPA receptor activation.

50 s accomplished by both activation of the Edg/LPA receptor and LPA-mediated transactivation of the epi

51 ion in human thyroid cancers correlated with LPA receptor and markers of aggressiveness including Ki6

52 Thus, LPA acts through LPA receptor and PPAR-gamma-dependent pathways to accele

53 P(A1)-1 and XLP(A1)-2 are functional Xenopus LPA receptors and demonstrate the evolutionary conservat

54 l via a signaling pathway involving specific LPA receptors and protein kinase D.

55 These data suggest that FAPs are ligands of LPA receptors and that FAP-10 and FAP-12 are the first r

56 o been analyzed and shown to require PLA(2), LPA receptors, and the mitogen-activated protein/extrace

57 ted receptors (PARs), lysophosphatidic acid (LPA) receptors, and sphingosine-1-phosphate (S1P) recept

58 at are attenuated by an NF-kappaB inhibitor, LPA receptor antagonists, and inhibitors of phosphoinosi

59 LPA receptors are widely expressed in the central nervou

60 6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors re

61 Of the classical LPA receptors belonging to the Edg family, lpa2 (edg4) i

62 and extend the functionality of LPA(4) as an LPA receptor, bringing the number of independently verif

63 to increased expression of the high-affinity LPA receptor, but activation of the low-affinity recepto

64 y shown to be antagonists for Xenopus laevis LPA receptors, did not antagonize the Ca2+-mobilizing ef

65 the frog oocyte for expression cloning of an LPA receptor DNA, an assay system made problematic by th

66 proach to further elucidate the functions of LPA receptors during red blood cell (RBC) differentiatio

67 encoding the putative lysophosphatidic acid (LPA) receptor Edg-2 (Vzg-1) in Saccharomyces cerevisiae

68 EDG-3, and EDG-5 and lysophosphatidic acid (LPA) receptors EDG-2 and EDG-4 suggested that its ligand

69 Schwann cells express the LPA receptors (Edg receptors), which, once activated, ha

70 rmal retina has a baseline expression of the LPA receptors, EDG-2 and EDG-4, which are significantly

71 wild-type Gab1 in HEK293 cells augmented the LPA receptor Edg2-mediated ERK2 activation.

72 kinase (ROCK) via the lysophosphatidic acid (LPA) receptor elicits clathrin-dependent Kv1.2 endocytos

73 nm) similar to that of the G protein-coupled LPA receptors encoded by endothelial differentiation gen

74 Increased ATX and LPA receptor expression have been found in numerous canc

75 ker phenotype, cytokines production, ATX and LPA-receptor expression, and phagocytosis.

76 es functional distinctions between different LPA receptor family members that are expressed constitut

77 The first identified LPA receptor gene, lp(A1)/vzg-1/edg-2, was previously sh

78 the first identified lysophosphatidic acid (LPA) receptor gene, lpA1 (also referred to as vzg-1 or e

79 expression pattern with the other two known LPA receptor genes (lp(A1)/Edg2 and lp(A2)/Edg4non-mutan

80 We examined whether any of the known LPA receptor genes (lp(A1)/Edg2, lp(A2)/Edg4, and lp(A3)

81 ghest expression levels of each of the three LPA receptor genes in adult mouse testes, relatively hig

82 subfamily, distinct from that containing the LPA receptor genes lpA1 and lpA2.

83 the present study, mRNA expression of all 6 LPA receptor genes was detected in murine aortic VSMCs,

84 To understand the evolution and function of LPA receptor genes, we characterized lp(A3)/Edg7 in mous

85 R, PSP24, was reported to be a high affinity LPA receptor in Xenopus laevis oocytes, raising the poss

86 AzoLPA shows greater activation of LPA receptors in its light-induced cis-form than its dar

87 strate for the first time the involvement of LPA receptors in mediating surprisingly diverse NPC calc

88 dentified essential biological functions for LPA receptors in mice.

89 -PCR revealed the presence of all five known LPA receptors in primary NPCs, with prominent expression

90 LPA receptors in RPE cells activate pertussis toxin (PTx

91 A, which might indicate the existence of two LPA receptors in these cells.

92 e expression of the endogenous high-affinity LPA receptors in Xenopus oocytes, whereas the same oligo

93 ry evidence that supports LPA(4) as a fourth LPA receptor, including LPA concentration-dependent resp

94 Here, we review current knowledge on these LPA receptors, including their isolation, function, expr

95 te the transcriptional mechanism and the Edg LPA receptors involved in LPA-induced IL-6 and IL-8 prod

96 We also evaluated LPA receptor involvement.

97 Using LPA receptor knockout mice, we previously uncovered a ro

98 There are currently four LPA receptors known as LPA(1-4).

99 a competitive inhibitor for the endothelial LPA receptor, loss of confluence in vitro and the hydrau

100 receptors have been identified as mammalian LPA receptors: LP(A1)/VZG-1/EDG-2, LP(A2)/EDG-4, and LP(

101 Expression of the LPA receptor LPA(5) was necessary for LPA-induced stimul

102 that deletion of the lysophosphatidic acid (LPA) receptor LPA(1), like that of the phospholipase PLA

103 KO mice of another Galpha(12/13)-coupling LPA receptor, LPA(6), also showed an attenuated LPA-indu

104 Two LPA receptors, LPA(1) and LPA(2), are expressed in the e

105 lymphocytes in mice and humans express three LPA receptors, LPA(2) , LPA(5,) and LPA(6) , and work fr

106 103 neuroblastoma cells devoid of endogenous LPA receptors, LPA(4) attenuated LPA(1)-driven migration

107 The lysophosphatidic acid (LPA) receptor LPA1/Edg2 is the first identified LPA rece

108 g transplant model of BOS, antagonism of the LPA receptor (LPA1) or ATX inhibition decreased allograf

109 ly act as agonists for the G-protein-coupled lpA receptors (LPA1, LPA2, and LPA3) and s1p receptors (

110 ere we show, for the first time, that type 2 LPA receptors (LPA2) are expressed at the apical surface

111 strong agonism of the lysophosphatidic acid (LPA) receptor LPA3.

112 lantation through the lysophosphatidic acid (LPA) receptor LPA3.

113 These results support GPR92 as a fifth LPA receptor, LPA5, which likely has distinct physiologi

114 We show LPA receptor (LPAR) signaling by CD8 T cells promotes to

115 EPH receptor and lysophosphatidic acid (LPA)-LPA receptor (LPAR) signaling.

116 This study determined which LPA receptor (LPAR) subtype(s) LPA signals through to st

117 other ccPA analogues were characterized for LPA receptor (LPAR) subtype-specific agonist and antagon

118 ysophosphatidic acid (LPA) signaling through LPA receptors (LPAR) plays an important role in breast c

119 by activation of the lysophosphatidic acid (LPA) receptor (LPAR) via SRC-dependent transactivation o

120 sophosphatidic acid (LPA) acting through the LPA receptor LPAR1.

121 wound-healing model; and 3) to identify the LPA receptors (LPARs) expressed by PDLF.

122 c acid (LPA) functions through activation of LPA receptors (LPARs).

123 GTPases through binding to G-protein-coupled LPA receptors (LPARs).

124 3T3 cells was mediated by the stimulation of LPA-receptors (LPARs) by LPA in the serum.

125 elevation of blood pressure through multiple LPA receptors, mainly LPA(4).

126 st cell lines in culture express one or more LPA receptors, making it difficult to assign a response

127 ession of structurally different subtypes of LPA receptors may provide one basis for tissue-specific

128 of both LPA-producing enzymes or of several LPA receptors may reveal the functional role of LPA sign

129 he mechanisms and specificity by which these LPA receptors mediate LPA actions are still poorly under

130 iates most of its biological effects through LPA receptors, of which six isoforms have been identifie

131 Our findings provide evidence for functional LPA receptors on microglia.

132 LPA receptors on platelets, leukocytes, endothelial cell

133 The opposite effects of Edg-2 and Edg-4 LPA receptors on trans-Matrigel migration and some other

134 (Neu*) or the ligand-dependent activation of LPA receptors or muscarinic receptors, which are two cla

135 ous G protein-coupled lysophosphatidic acid (LPA) receptors or by transient expression of Gbetagamma

136 In RH7777 cells lacking LPA receptors, OTP selectively protected LPA(2) but not

137 of LPA on GROalpha expression is mediated by LPA receptors, particularly the LPA(2) receptor in that

138 Thrombin and lysophosphatidic acid (LPA) receptors play important roles in vascular biology,

139 Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 product

140 vity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actio

141 sible photoreactive alkylating agent for the LPA receptor(s).

142 ion of novel agonists and antagonists of the LPA receptor(s).

143 the free hydroxyl group in order to evaluate LPA receptor SAR.

144 1-phosphate (S1P) and lysophosphatidic acid (LPA) receptor sequences were used to design semi-redunda

145 ATX-LPA receptor signaling is essential for normal developme

146 These results suggest that LPA receptor signaling may play an important role in neu

147 with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA.

148 ICl(LPA) in a dose-dependent manner, and the LPA receptor-specific antagonist dioctyl-glycerol pyroph

149 of beta-arrestins in lysophosphatidic acid (LPA) receptor-stimulated ERK1/2 activation using fibrobl

150 MAP kinase activation resulting from LPA receptor stimulation, expression of Gbetagamma subun

151 se, glutamine 125, which is conserved in the LPA receptor subfamily (LPA(1)/EDG2, LPA(2)/EDG4, and LP

152 action of LPA is mediated through LPA(2), an LPA receptor subtype overexpressed in ovarian cancer and

153 gnaling in neuropathic pain through a second LPA receptor subtype, LPA(5), involving a mechanisticall

154 operties of LPA has been hampered by lack of LPA receptor subtype-specific agonists and antagonists.

155 riments showed the presence of RNA for three LPA receptor subtypes (Edg2, -4, and -7); RNase protecti

156 vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediate

157 LPA(2) differs from other LPA receptor subtypes in the C-terminal tail, where it c

158 The pharmacological activation of LPA receptor subtypes represent a novel strategies for a

159 LPA exhibits agonistic activity on all three LPA receptor subtypes, whereas OMPT has a potent agonist

160 y dermal and epidermal expression of several LPA receptors, suggesting that LPA signaling could contr

161 in EC(50) in response to LPA but caused the LPA receptors to become more responsive to sphingosine 1

162 ringing the number of independently verified LPA receptors to five, with both overlapping and distinc

163 LPA receptor transduction was analyzed in human and rat

164 This study reveals that LPA signaling via LPA receptor type 1 activation causes demyelination and

165 LPA) is a potent inducer of colon cancer and LPA receptor type 2 (LPA(2)) is overexpressed in colon t

166 Analysis of this series at each recombinant LPA receptor using a guanosine 5'-O-(3-[35S]thio)triphos

167 ory responses elicited by Gi protein-coupled LPA receptors via the Gbetagamma subunit complex.

168 ory responses elicited by Gi protein-coupled LPA receptors via the GBy subunit complex.

169 al LPA analogs with varied affinity for each LPA receptor, we found a good correlation between the hy

170 Toward identifying new LPA receptors, we have screened collections of GPCR cDNA

171 A1/vzg-1 in the VZ suggested that functional LPA receptors were synthesized at these early times, and

172 acellularly and signals to cells via cognate LPA receptors, which are G-protein coupled receptors (GP

173 to examine the functional interaction of the LPA receptor with G proteins in intact mouse fibroblasts

174 of cPA lack significant agonist activity at LPA receptors yet are potent inhibitors of ATX activity,