ライフサイエンスコーパス: LRP

1 LRP blockade and inhibition of PKA prevented uPA- and uP

2 LRP emerge through overlying root tissues by inducing au

3 LRP growth was delayed in cell-death-deficient mutants l

4 LRP growth was restored in ore1-2 knockout plants by gen

5 LRP most efficiently neutralized the LPS-induced pro-inf

6 LRP-1 expression on peripheral blood DCs was quantified

7 LRP-1 is not known to modulate the pathogenesis of aller

8 LRP-1-deficient macrophages, isolated from mice, demonst

9 LRPs are associated with acute coronary syndromes or myo

10 own to interact with LDLR-related protein 1 (LRP) through these clusters.

11 sity lipoprotein receptor-related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive i

12 sity lipoprotein receptor-related protein 1 (LRP-1) receptor with receptor-associated protein (RAP) o

13 sity Lipoprotein Receptor-Related Protein 1 (LRP-1) receptor.

14 sity lipoprotein receptor-related protein 1 (LRP-1) was present during infection.

15 eceptor, the LDL receptor-related protein 1 (LRP-1).

16 sity lipoprotein receptor-related protein 1 (LRP/CD91), by defense collagens has been suggested as on

17 sity lipoprotein receptor-related protein-1 (LRP) antibody and an LRP antagonist, receptor-associated

18 sity lipoprotein receptor-related protein-1 (LRP-1) plays a major role in TIMP-3 internalization.

19 ipoprotein (LDL) receptor-related protein-1 (LRP-1) to become enzymatically active.

20 kinase AXL, LDL receptor-related protein-1 (LRP-1), and RAN-binding protein 9 (RANBP9)--that mediate

21 e in lipoprotein receptor related protein-1 (LRP-1)-targeted functionalized polymersomes in experimen

22 ts receptor, LDL receptor-related protein-1 (LRP-1).

23 sity lipoprotein receptor-related protein-1 (LRP-1).

24 poprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/beta-catenin si

25 Here we develop a fast and accurate LRP method, Eagle, that extends this paradigm to populat

26 In addition, LRP-deficient and -expressing macrophages ingested equiv

27 In addition, LRPs induced improved cell-cycle progression and perfori

28 ptor-related protein-1 (LRP) antibody and an LRP antagonist, receptor-associated protein (RAP), and w

29 g Schwann cell signaling and migration by an LRP-1-dependent pathway.

30 cell survival, whereas re-introduction of an LRP-1 minigene in a mouse LRP-1-deficient fibroblast cel

31 receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/beta-catenin signaling, e

32 kably similar to the time course of ADAN and LRP.

33 AXL and LRP-1 did not interact directly, but relied on RANBP9, w

34 t relied on RANBP9, which bound both AXL and LRP-1, to form the complex.

35 deep learning framework combining 3D CNN and LRP algorithms can be used with tau PET images to identi

36 tantial binding to von Willebrand factor and LRP.

37 P(2)) production, signalosome formation, and LRP phosphorylation.

38 cs indicate that Glut4, the Tf receptor, and LRP-1 are differentially processed both within the cell

39 e from healthy controls not affected by anti-LRP, suggesting that the LRP-CRT pathway was disturbed b

40 athway includes the canonical elements arrow/LRP (low-density lipoprotein receptor-related protein),

41 isms and that pharmacologic targets, such as LRP, might prove useful in restoring function in HAD pat

42 lture model of antigen presentation, the AXL/LRP-1/RANBP9 complex was used by DCs to cross-present AC

43 es Abeta generation by scaffolding APP/BACE1/LRP complexes together.

44 interacted much more strongly with APP/BACE1/LRP than full-length RanBP9.

45 n resonance to evaluate the affinity between LRP-1 and a number of MMPs, ADAMs, ADAMTSs, TIMPs and me

46 tudy was to evaluate the association between LRP detected by near-infrared spectroscopy (NIRS) and cl

47 aimed to establish the relationship between LRPs detected by NIRS-intravascular ultrasound imaging a

48 Biochemically, LRP-6 interacts closely with PDGF receptor beta and TGF-

49 production of active heparanase by blocking LRP-1-mediated uptake of pro-heparanase and thereby decr

50 ZIP1L suppression significantly delayed both LRP and LR formation.

51 e, the extract induced liver, but not brain, LRP and NEP and decreased plasma and brain Abeta, indica

52 This response was blocked by LRP-1 gene silencing or by co-incubation with the LRP-1

53 ke of the R2159N variant was reduced both by LRP-expressing U87-MG cells and by human monocyte-derive

54 e interactions as well as cellular uptake by LRP-expressing cells.

55 The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and

56 Most commonly, LRP initiation starts with the specification of just one

57 rimary root, plays a new role in controlling LRP development at later stages.

58 a high CACS considering that it is coronary LRP, rather than calcification, that underlies the major

59 nal-disrupting oncolytic adenovirus (oAd/DCN/LRP) to achieve a desirable therapeutic outcome against

60 d with a cognate control lacking NT (oAd/DCN/LRP-PEG).

61 The oAd/DCN/LRP-PEG-NT elicited increased NTR-selective cancer cell

62 ther, these results demonstrate that oAd/DCN/LRP-PEG-NT has strong therapeutic potential for systemic

63 thermore, systemic administration of oAd/DCN/LRP-PEG-NT significantly decreased induction of innate a

64 argeting and therapeutic efficacy of oAd/DCN/LRP-PEG-NT toward neurotensin receptor 1 (NTR)-overexpre

65 icantly enhanced antitumor effect of oAd/DCN/LRP-PEG-NT was mediated by active viral replication and

66 stemically injectable hybrid system, oAd/DCN/LRP-PEG-NT.

67 effect that is attenuated in LRP-deficient (LRP(-/-)) mouse embryonic fibroblasts.

68 g stents, stent implantation in NIRS-defined LRPs was not associated with increased periprocedural or

69 anted 5.5+/-4.0 years earlier, NIRS detected LRP in 33%.

70 ase, then later at the flanks, of developing LRPs.

71 abundance in the tonoplast of the different LRP cells is pivotal to mediating this developmental pro

72 e properties of overlaying tissues disrupted LRP morphogenesis.

73 ion in the latter population of cells during LRP morphogenesis are not stereotypical.

74 role for MYB36 outside the endodermis during LRP development through a mechanism analogous to regulat

75 ression pattern of the NRT1.1 protein during LRP development and combined local transcript analysis w

76 Finally, inhibition of either LRP or gamma-secretase attenuated cerebral ischemia-indu

77 rference screen using Caenorhabditis elegans LRP-1/megalin as a model for LDLR transport.

78 AP-D3 interfere with transport of endogenous LRP-1 to the cell surface in a dominant negative fashion

79 These results establish LRP-1 as a cell-signaling receptor for MMP-9, which may

80 esponses in pericycle cells between existing LRP might restrict LRI near existing LRP and, when compr

81 xisting LRP might restrict LRI near existing LRP and, when compromised, ectopic LRI occurs.

82 ity to replicate in cancer cells and express LRP in vitro.

83 h the observation that Schwann cells express LRP-1 at significant levels only after nerve injury.

84 frared spectroscopy images were analyzed for LRP, defined as a bright yellow block on the near-infrar

85 In contrast, the k(ex) for LRP-1 was five times faster than Glut4 in basal cells, a

86 pattern of divisions, is most important for LRP morphogenesis and optimizes the process of lateral r

87 he affinity of target metalloproteinases for LRP-1, albeit to a lesser extent.

88 MP-1 was found to have a K(D) of 34.6 nM for LRP-1, while the MMP-1/TIMP-3 complex had a sevenfold hi

89 The potential for LRP-mediated chemoattraction to mediate axonal regenerat

90 This identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive im

91 nophilic asthma suggests a possible role for LRP-1 in modulating type 2-high asthma.

92 is region of ApoE to a high-affinity CR from LRP (CR17) for structural elucidation of the complex.

93 -catenin signaling is independent of the FZD/LRP heterodimeric receptors and Wnt ligands.

94 promotes internalization of the Wnt9a-Fzd9b-LRP signalosome and subsequent signal transduction.

95 G47Delta-LRP was then tested for its therapeutic effectiveness an

96 r therapeutic effectiveness between G47Delta-LRP and G47Delta-empty virus.

97 e and 8-10 hours after injection of G47Delta-LRP (n = 7) or G47Delta-empty virus (n = 6).

98 ability of CEST MR imaging to show G47Delta-LRP at acute stages of viral infection.

99 served between tumors infected with G47Delta-LRP and G47Delta-empty virus.

100 0.3, P = .02) after infection with G47Delta-LRP but not G47Delta-empty viruses.

101 es derived from cells infected with G47Delta-LRP or the control G47Delta-empty virus.

102 Megalin (gp330, LRP-2) is a protein structurally related to the low-dens

103 activation, an effect that is attenuated in LRP-deficient (LRP(-/-)) mouse embryonic fibroblasts.

104 ng the spatiotemporal expression of PDLP5 in LRP-overlying cells into known auxin-regulated LRP-overl

105 rupting (or enhancing) expression of RBOH in LRP and/or overlying root tissues decelerates (or accele

106 tability both in primary root tissues and in LRPs, it acts differentially on protein accumulation, de

107 n of AtTIP1;1 and AtTIP1;2 protein levels in LRPs, expression of AtTIP2;1 is specifically needed in a

108 bstitution rates were significantly lower in LRPs than HRPs, especially for sets of internal branches

109 on of NRT1.1, which is markedly repressed in LRPs in the absence of NO3(-) To explain this discrepanc

110 the primary root and a strong repression in LRPs and to a lower extent at the primary root tip.

111 e features of the CD8(+) T cell responses in LRPs toward emerging epitope variants provide insights i

112 iated protein that inhibits ischemia-induced LRP, a signaling receptor for t-PA.

113 The viral population infecting LRPs was also characterized by a slower increase in syno

114 ceptor responsible for ADAMTS-5 clearance is LRP-1.

115 s overlying the LRP or by physically killing LRP-overlying cells by ablation with optical tweezers.

116 Large LRP having a maximum LCBI in 4 mm >/=400 were infrequent

117 he lipid core burden index (LCBI), and large LRP were defined as a maximum LCBI in 4 mm >/=400.

118 Enrolled patients with large LRPs (>=250 maxLCBI(4mm)) and a randomly selected half o

119 tasis, has been shown to interact with LDLR, LRP, and VLDLR, through these clusters.

120 ties, four 15-residue peptides with leucine (LRP), phenylalanine (FRP), valine (VRP), and alanine (AR

121 However, significant increase in liver LRP and NEP occurred much earlier, at 7 d, and were acco

122 ain Abeta, indicating that increase in liver LRP and sLRP occurring independent of Abeta concentratio

123 fera mediated through up-regulation of liver LRP indicates that targeting the periphery offers a uniq

124 Selective down-regulation of liver LRP, but not NEP, abrogated the therapeutic effects of t

125 patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic su

126 Insulin increased k(en) for alpha-2-M/LRP-1 by 30%.

127 In basal cells, the k(en) for alpha-2-M/LRP-1 was similar to Glut4 but 5-fold slower than Tf.

128 (Tf) and alpha(2)-macroglobulin (alpha-2-M; LRP-1) were compared using quantitative flow cytometric

129 to outline the recycling pathway of Megalin (LRP-2), an apical receptor with key developmental and re

130 the LDL receptor superfamily (LDLR, megalin, LRP).

131 herefore, we hypothesized that DENV modifies LRP-1 protein expression to maintain host-derived intrac

132 introduction of an LRP-1 minigene in a mouse LRP-1-deficient fibroblast cell line (PEA-13) restored t

133 This identified MMP-1 as a new LRP-1 ligand.

134 ion to two adjacent cell files overlying new LRP is crucial to ensure that auxin-regulated cell separ

135 analysis demonstrated that the shape of new LRPs is highly conserved.

136 Despite a high CACS, no LRP was detected in 8 (40.0%) subjects.

137 Notably, LRP-1-mediated endocytosis of ADAMTS-5 is impaired in ch

138 n the mutant primordia, rendering "PLT-null" LRP.

139 sites within the cluster and the ability of LRP to discriminate in vivo between uncomplexed and prot

140 ry mediators was explained by the ability of LRP-1 to suppress basal cell signaling through the I kap

141 studies demonstrate a direct contribution of LRP to phagocytosis and indicate that LRP is not require

142 isease was assessed in mice with deletion of LRP-1 in CD11c(+) cells (Lrp1(fl/fl); CD11c-Cre) and by

143 The detection of LRP in a pre-existing stent by NIRS alone is not reliabl

144 d states to (CR)(2) and (CR)(3) fragments of LRP cluster II.

145 small interfering RNA-mediated knockdown of LRP, mannose receptor, or DC-SIGN expression in monocyte

146 Deletion or knockdown of LRP-1 abolished tPA-mediated cell survival, whereas re-i

147 We also found that dsRNA knockdown of LRP-1 increased intracellular cholesterol and DENV viral

148 oximately 90% reduction in protein levels of LRP-1 without changes in its mRNA levels.

149 and for the analysis of the oncogenicity of LRP receptors that are often overexpressed in breast tum

150 aurora1 (aur1) aur2 disrupts the pattern of LRP cell divisions and impacts its growth dynamics, yet

151 nisms controlling proliferation potential of LRP cells remains poorly understood.

152 e fraction of pixels with the probability of LRP >0.6 within a region of interest.

153 uired during the highly regulated process of LRP morphogenesis and emergence.

154 duces regulated intramembrane proteolysis of LRP and whether this process is related to cell death.

155 iated regulated intramembrane proteolysis of LRP results in cell death under ischemic conditions.

156 The ligand binding regions of LRP consist of clusters of cysteine-rich approximately 4

157 This phenotype was due to the retardation of LRP emergence.

158 In this study we investigated the role of LRP in cell death.

159 The role of LRP-1 in modulating HDM-induced airways disease was asse

160 ly slowed down after 10 h due to shedding of LRP-1 from the cell surface and formation of soluble LRP

161 At the site of LRP detected by NIRS in a cohort of pre-existing stents,

162 absence of neointimal tissue at the site of LRP detected by NIRS, intravascular ultrasound may provi

163 At the site of LRP, intravascular ultrasound found no neointimal tissue

164 A subset of LRP-overlying cells displayed the induction of marker ge

165 ration/activation by mechanisms dependent on LRP-6 and WNT ligands but not the downstream beta-cateni

166 re expression of normal RAP has no effect on LRP-1 transport.

167 sion, organ shape, and overlaying tissues on LRP morphogenesis by exploiting recent advances in live

168 ivision pattern versus overlaying tissues on LRP morphogenesis using mutant and transgenic approaches

169 Conversely, only one LRP ligand, metallothionein II, was found to be chemoatt

170 Upon treatment of DCs with mannan or LRP ligand alpha2-macroglobulin, we observed only a mino

171 or with receptor-associated protein (RAP) or LRP-1 siRNA abolished the ApoE effects.

172 mata, is induced by auxin in cells overlying LRP in a progressive manner.

173 smodesmal regulator PDLP5 in cells overlying LRP, creating a negative feedback loop.

174 concentrating this signal in cells overlying LRP.

175 ic population to perform long-range phasing (LRP), enabling accurate imputation and association analy

176 that implanting stents in lipid-rich plaque (LRP) may be associated with adverse outcomes.

177 e the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high c

178 ging phenomenon in which lipid-rich plaques (LRPs) develop within pre-existing stents.

179 sound imaging can detect lipid-rich plaques (LRPs).

180 In the peripheral nervous system (PNS), LRP-1 is robustly expressed by Schwann cells only after

181 unlike non-targeted carnosine polymersomes, LRP-1-targeted carriers accumulated in brain in a time d

182 rise in the lateralized readiness potential (LRP) on a subset of biased payoff trials contralateral t

183 The lateralized readiness potential (LRP), an electrophysiological index of response preparat

184 AN) and the lateralized readiness potential (LRP).

185 nse-locked lateralized readiness potentials (LRPs).

186 ing Lys(1370) and Lys(1374), which precludes LRP-1 binding.

187 s overexpressing PtabZIP1L showed precocious LRP and LR development, while PtabZIP1L suppression sign

188 ion of LR pre-branch sites and LR primordia (LRP).

189 larly in zones where lateral root primordia (LRP) initiate and LR differentiate and emerge.

190 formation, when the lateral root primordia (LRP) must traverse three overlying cell layers within th

191 Lateral root primordia (LRP) originate from pericycle stem cells located deep wi

192 s, the morphology of lateral root primordia (LRP), the auxin response gradient, and the expression of

193 roper development of lateral root primordia (LRP).

194 isions that generate lateral root primordia (LRP).

195 presses emergence of lateral root primordia (LRPs) at low concentration or absence of NO3(-) through

196 In Arabidopsis, lateral root primordia (LRPs) originate from pericycle cells located deep within

197 the emergence of new lateral root primordia (LRPs).

198 However, early LR primordium (LRP) morphogenesis is not fully understood.

199 equires the outgrowth of the new primordium (LRP) to coincide with the timely separation of overlying

200 uently purified to a lactulose-rich product (LRP; approximately 70% lactulose content to total sugar)

201 gressors (HRPs) versus low-risk progressors (LRPs).

202 progressors (HRPs) and low-risk progressors (LRPs).

203 The layer-wise relevance propagation (LRP) results were consistent with those from the voxel-w

204 ively by laparoscopic radical prostatectomy (LRP) between July 2014 and January 2019 with localized p

205 38B treatment, the receptor guidance protein LRP-1, which is required for endosomal recycling of the

206 ensity lipoprotein receptor-related protein (LRP) 5/6 is unknown.

207 ensity lipoprotein receptor-related protein (LRP) and cell surface glucose-regulated protein [Mr appr

208 th the lipoprotein receptor-related protein (LRP) and its ligand, calreticulin (CRT), because the LRP

209 ensity lipoprotein receptor-related protein (LRP) because the specific LRP blocker, receptor associat

210 nt/Fzd/lipoprotein receptor-related protein (LRP) complex and the associated beta-catenin signaling b

211 ensity lipoprotein receptor-related protein (LRP) in brain microvessels and the Abeta-degrading prote

212 ensity lipoprotein receptor-related protein (LRP) is the principal clearance receptor for serpins and

213 ids of lipoprotein receptor-related protein (LRP) robustly promoted Abeta generation independent of F

214 ocking lipoprotein receptor-related protein (LRP), a CRT receptor on macrophages.

215 ensity lipoprotein receptor-related protein (LRP), a member of the low-density lipoprotein receptor g

216 ensity lipoprotein receptor-related protein (LRP), amyloid precursor protein (APP), and BACE1 and rob

217 ensity lipoprotein receptor-related protein (LRP).

218 aling pathway: LDL receptor-related protein (LRP-1) and decorin.

219 ensity lipoprotein receptor-related protein (LRP-1) functions in endocytosis and in cell signaling di

220 ensity lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, in

221 ensity lipoprotein receptor-related protein (LRP-1), an endocytic receptor with cell signaling activi

222 A lysine-rich protein (LRP) chemical exchange saturation transfer (CEST) MRI re

223 ensity lipoprotein receptor-related protein [LRP] 5/6), dishevelled (dsh), casein kinase Igamma, G pr

224 D] and lipoprotein receptor-related protein [LRP] family members) and the downstream beta-catenin eff

225 nsity lipoprotein receptor-related proteins (LRPs), and siRNA-mediated gene silencing revealed that t

226 The adoptive transfer of HDM-pulsed LRP-1-deficient CD11b(+) DCs into WT mice generated a si

227 ion of the Abeta vascular clearance receptor LRP-1, and protection from the deleterious effects of Ab

228 M1 macrophage survival through its receptor LRP-1-mediated novel signaling cascade involving Erk1/2,

229 Low-density lipoprotein receptors (LRPs) are present extensively on cells outside of the ne

230 Here we report the use of a redesigned LRP reporter (rdLRP), aimed to provide excellent stabili

231 present during flavivirus infection reduced LRP-1 protein expression.

232 Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients

233 gether, these data suggest that DENV reduces LRP-1 protein expression, possibly through regulated int

234 P-overlying cells into known auxin-regulated LRP-overlying cell separation pathways, and speculate ho

235 We found that AXL bound ACs, but required LRP-1 to trigger internalization, in murine CD8alpha+ DC

236 transfer living radical polymerization (SET-LRP) in water is described.

237 also conducted as a comparison with the SET-LRP system.

238 Similarly, LRP-1 expression by CD11b(+) lung DCs was significantly

239 andomly selected half of patients with small LRPs (<250 maxLCBI(4mm)) were followed up for 24 months.

240 om the cell surface and formation of soluble LRP-1 (sLRP-1)-TIMP-3 complexes.

241 virus-1 infection, mice lacking DC-specific LRP-1, AXL, or RANBP9 had increased AC accumulation, def

242 r-related protein (LRP) because the specific LRP blocker, receptor associated protein (RAP), prevente

243 /4D image analysis revealed that early stage LRPs exhibit tangential divisions that create a ring of

244 In this prospective, cohort study (LRP), patients from 44 medical centres were enrolled in

245 alpha action, or removal of the cell surface LRP-1 receptor for secreted Hsp90alpha reduces the tumor

246 MYB36 was expressed in the cells surrounding LRP where it controls a set of peroxidase genes, which m

247 howed significantly lesser cytotoxicity than LRP and FRP; further, the replacement of leucines with v

248 was found that lactose is more reactive than LRP for Maillard conjugation with both WPI and WPH.

249 ion of LRP to phagocytosis and indicate that LRP is not required for the C1q-triggered enhancement of

250 We propose that LRP-1 suppresses expression of inflammatory mediators in

251 ding studies using Fc chimeras revealed that LRP, DC-SIGN, and mannose receptor can bind to FVIII; ho

252 We show that LRP-1 is associated with endothelial transcytosis that d

253 Furthermore, the data suggest that LRP-mediated chemoattraction represents a novel, non-cla

254 Previous literature suggests that LRP-1 regulates cholesterol homeostasis.

255 This suggests that LRP-1 scavenging of TIMP/metalloproteinase complexes may

256 The LRP and lactose were then conjugated with either whey pr

257 The LRP gene was detected through CEST imaging of lysates de

258 The LRP model identified the brain regions in tau PET images

259 The LRP size and shape depends on the balance between positi

260 The LRP-1-targeted functionalization was essential for deliv

261 essed the growth factor carrier site and the LRP-1 recognition domain (RBD) as separate GST fusion pr

262 its ligand, calreticulin (CRT), because the LRP-mediated increase in phagocytosis of viable neutroph

263 Both apoE and pro-heparanase bind the LRP-1.

264 with LRP1 is direct, and is modulated by the LRP chaperone, Receptor-Associated Protein (RAP).

265 es simplex virus G47Delta, which carried the LRP gene, was constructed and tested for its capacity to

266 her beta-propeller containing protein in the LRP family).

267 s before stimulus information influenced the LRP.

268 proliferating and arrested cells inside the LRP, coinciding with the change from flat to dome-shaped

269 Interestingly, the LRP emergence phenotype of the triple tip mutants could

270 ximately 400 ms) and the peak latency of the LRP (approximately 1200 ms).

271 usion (MCAO) in mice induces shedding of the LRP ectodomain, we investigated here whether cerebral is

272 This can aid in development of the LRP gene as a reporter for the real-time detection of vi

273 However, the highly repetitive nature of the LRP reporter gene sequence leads to DNA recombination ev

274 The introduction of the LRP transgene had no effect on the viral replication or

275 cing cell elimination in cells overlying the LRP or by physically killing LRP-overlying cells by abla

276 ot affected by anti-LRP, suggesting that the LRP-CRT pathway was disturbed by PR3-CRT association.

277 gene silencing or by co-incubation with the LRP-1 antagonist, receptor-associated protein.

278 ssues place biomechanical constraints on the LRPs that are likely to impact their morphogenesis.

279 mainly drove these differences, whereas the LRPs maintained a directed and maintained functional res

280 Therefore, LRP initiation is a gradual, multistep process.

281 Thus, LRP-1 dictates physiological and pathological catabolism

282 arly bridged binding of MMP-13 and MMP-14 to LRP-1.

283 utant that binds to GRP78 but cannot bind to LRP regulates DNA and protein synthesis by human prostat

284 acids, is responsible for decorin binding to LRP-1 and subsequent TGF-beta-dependent signaling.

285 alloproteinases by bridging their binding to LRP-1.

286 Among the proteins analyzed, TIMP-3 bound to LRP-1 with highest affinity (K(D) = 1.68 nM).

287 s and the expression of a range of truncated LRP protein fragments, thereby greatly limiting the CEST

288 MAPK and JNK signaling cascades, acting via LRP-6 with associated WNT ligand.

289 es of rdLRP transfected cells and in in vivo LRP expressing mouse brain tumors ([Formula: see text],

290 roteases accumulate at increased levels when LRP-1 is absent.

291 ingle ligand binding repeat cluster, whereas LRP contains three large clusters of ligand binding repe

292 We sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adap

293 The mechanism by which LRP-1 inhibits NF-kappaB activity involves down-regulati

294 g SPRY-LisH domains not only interacted with LRP but also with APP and BACE1.

295 in that are responsible for interaction with LRP-1 and are involved in TGF-beta-dependent binding and

296 and LRR5 participate in the interaction with LRP-1 and TGF-beta as well as in its dependent signaling

297 f MMP-9, which mediates the interaction with LRP-1, blocked MMP-9-induced cell signaling and migratio

298 in the enhancement of APP interactions with LRP and BACE1 and increased lipid raft association of AP

299 ndependently of C1 and its interactions with LRP.

300 thermore, our results demonstrate that young LRP are more sensitive to perturbations in the cytokinin