ライフサイエンスコーパス: LTP

1 LTP has also been used for surface disinfection.

2 LTP involves local remodeling of dendritic spines and sy

3 LTP treatment can be considered as an effective method f

4 LTP was calcium dependent, required the activation of bo

5 LTP, a fundamental mechanism of learning and memory, is

6 LTP-IE 'tags' specific neurons with increased spiking pr

7 LTP-like cortical plasticity might therefore represent a

8 LTP-like plasticity in M1 was abolished (p = 0.008) and

9 naptic LTP depend on dendritic location; (2) LTP of input patterns that are subthreshold or suprathre

10 included and classified into two groups; (a) LTP-monoallergic: those that presented reaction only wit

11 role in the pathophysiology of the abnormal LTP-like plasticity in PD.

12 Loss of both CAMK2 isoforms abolished LTP, whereas synaptic transmission remained intact.

13 Additionally, LTP and LTD are correlated with dendritic spine enlargem

14 iation, we tested how PKA inhibition affects LTP.

15 ngle tubule to complex spine apparatus after LTP.

16 Total SER volume decreased after LTP consistent with transfer of membrane to the added sp

17 tion, synapses were enlarged two hours after LTP on resource-rich spines containing polyribosomes (4%

18 rs, small spines lacking SER increased after LTP, whereas large spines did not change in frequency, s

19 elevated specifically in small spines after LTP.

20 , deletion of Pyk2 expression does not alter LTP under control conditions.

21 dylinositol transfer protein Nir2 acts as an LTP and may replenish PI at the HCV RO by interacting wi

22 Future studies that analyze LTP responder survival and implementation lag would faci

23 Both cell surface receptor accumulation and LTP facilitation were present even after sAPPalpha washo

24 on (SAI), long-afferent inhibition (LAI) and LTP-like plasticity following paired associative stimula

25 dversity prevented the consequent memory and LTP defects.

26 ntiation (LTP) in transplant recipients, and LTP impairment in TRANSWT mice was IL-1 dependent.

27 drives increased AMPA receptor recycling and LTP.

28 amplitude of glutamatergic transmission and LTP suppression observed in young Trem2(R47H/R47H) rats.

29 peptides of Len c 1.0101, Len c 1.0102, and LTPs allergens were further determined with multiple rea

30 t presented reaction only with peach and (b) LTP-Allergy: those that presented reaction with peach an

31 f CA1 pyramidal neurons and in vitro blocked LTP-induced surface delivery of AMPA receptors and spine

32 l epithelium of NEGATIVE, GAS, CHX, and both LTP groups.

33 e-alpha (DAGL-alpha) impairs hippocampal CA1 LTP, differentially disrupts spatial learning and memory

34 partial depletion of BACE1 still induces CA1 LTP impairment, supporting a role of BACE1 in synaptic p

35 h and at least another plant-food containing LTP.

36 Although control LTP was impaired in the young transgenic mice, it was no

37 It is known that BDNF can control LTP maintenance through protein kinase Mzeta (PKMzeta),

38 cortical thickness or at least abolished DCS-LTP.

39 erm potentiation (LTP)-like enhancement (DCS-LTP) was recorded in deep cortical layers.

40 lly, increased Rbfox1 impairs BDNF-dependent LTP which can be rescued by genetically restoring TrkB.T

41 the role of neuroligin-1 in NMDAR-dependent LTP.

42 methyl-D-aspartate (NMDA) receptor-dependent LTP requires trans-synaptic binding of postsynaptic neur

43 istamine facilitates NMDA receptor-dependent LTP via H(3) receptors during the second postnatal week,

44 We report that spike-timing dependent LTP at the synapse between PV-INs and principal neurons

45 Additionally, both direct LTP treatment and plasma-activated media were effective

46 s in the on state, rather than by disrupting LTP induction.

47 etion or pharmacological inhibition disrupts LTP in CA1 of the hippocampus but elicits varying magnit

48 y, there were no observed differences during LTP in comparison to control mice.

49 aintaining the structure of the spine during LTP.

50 GRIP1 is recruited into synapses during LTP, and deletion of Grip1 in neurons blocks synaptic AM

51 of extracellular glutamate transients during LTP induction and characterized the sensitivity of the r

52 proteins leading to the conversion of early LTP into late LTP and of short-term memory into long-ter

53 e right BLA might contribute to the enhanced LTP.

54 anning microscopy were performed to evaluate LTP's antimicrobial effect.

55 Additionally, experimentally evoked LTP in vivo was increased in 5xF:pGB mice.

56 term potentiation of intrinsic excitability (LTP-IE).

57 nockdown enhances CA1 neuronal excitability, LTP and long-term memory whereas its overexpression weak

58 ation necessary for inducing more excitatory LTP.

59 Induction of excitatory LTP relocates alpha5-GABARs, which are ordinarily extras

60 ity that prevents accumulation of excitatory LTP.

61 such training, and with a failure to exhibit LTP after aggression training.

62 eceptors to the cell surface that facilitate LTP.SIGNIFICANCE STATEMENT Secreted amyloid precursor pr

63 We hypothesized that sAPPalpha facilitated LTP via regulated glutamate receptor trafficking and de

64 sAPPalpha thus facilitates LTP through coordinated activation of protein synthesis

65 Following LTP, "nonresponders" were those with <20% IOP reduction

66 y resource-poor spines, especially following LTP.

67 ent in dendritic shafts, to spines following LTP stimulation.

68 ith elevated total synaptic weight following LTP.

69 tracted if the eye had a procedural code for LTP and a glaucoma diagnosis.

70 ynaptic targeting of AMPARs, is required for LTP and learning and memory.

71 the same between sexes, PKA is required for LTP in females but not males.

72 hly enriched in synapses and is required for LTP.

73 ) of the AMPAR subunit GluA1 is required for LTP.

74 ivity prediction for patients suffering from LTP allergy and facilitates design of therapeutics.

75 Furthermore, LTP stimulation led to an increase in surface-expressed

76 ficant correlation was found between greater LTP-like cortical plasticity and poorer cognitive inhibi

77 252 patients were included, 235 (93.2%) had LTP-syndrome and 17 (6.8%) were LTP-monoallergic.

78 a2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2alpha phosphorylation, providin

79 1 knockout mice exhibit impaired hippocampal LTP, as well as deficits in learning and memory.

80 and analyses of mAb reactivity to homologous LTPs revealed three structural epitopes: two partially c

81 We further show how LTP-IE can implement temporary stimulus-response mapping

82 In the older transgenic mice, however, LTP was impaired in a way that occluded further reductio

83 Eyes were excluded if LTP laterality or baseline intraocular pressure (IOP) co

84 poor glutamate uptake can negatively impact LTP consolidation.SIGNIFICANCE STATEMENT Specific patter

85 d NMDAR-mediated depolarization and impaired LTP induction.

86 nching, reduced spine head size and impaired LTP.

87 dysregulation, depolarization, and impaired LTP.

88 c removal of extracellular l-serine impaired LTP, supporting an l-serine shuttle mechanism between gl

89 Moreover, the impaired LTP in aged APP/PS1 mice is rescued by incubation with a

90 kade of Rac1 activity rescued impairments in LTP and object location memory performance in cKO mice.

91 n frequencies, accompanied by an increase in LTP.

92 his study indicates a novel role for MAP2 in LTP mechanisms and suggests that MAP2 participates in ac

93 roles of different signalling mechanisms in LTP induction.

94 icing switch may play a sex-specific role in LTP-associated increases in presynaptic release probabil

95 Ca(2+) that induce NMDA receptor independent LTP in hippocampal oriens interneurons.

96 f cholinergic axons was sufficient to induce LTP, which was prevented by chelating postsynaptic Ca(2+

97 he adult rat hippocampus during BDNF-induced LTP.

98 -Y876) is elevated during chemically induced LTP.

99 red at gamma frequency promotes iTBS-induced LTP-like plasticity in M1 in PD patients.

100 treatment was able to block oligomer-induced LTP inhibition in sham but not in TBI animals.

101 ency stimulation-induced and pairing-induced LTP is the same between sexes, PKA is required for LTP i

102 Low-frequency stimulation induced LTP of synaptic zinc signaling (Z-LTP), evidenced by enh

103 NFalpha is known to be capable of inhibiting LTP and is upregulated several-fold in brain tissue, ser

104 different to those obtained from the Italian LTP subjects, with significant correlations between Pru

105 Importantly, L-LTP failure and cognitive impairments displayed in AMPKa

106 emory, spine density, synaptic plasticity (L-LTP), and potentiates perseverative/repetitive behavior

107 d hippocampal late long-term potentiation (L-LTP).

108 exposure to sAPPalpha converts short-lasting LTP into protein-synthesis-dependent late LTP in hippoca

109 ng LTP into protein-synthesis-dependent late LTP in hippocampal slices from male rats.

110 ing to the conversion of early LTP into late LTP and of short-term memory into long-term memory.

111 induction protocol for mTORC1-mediated late-LTP in SOM-INs regulated Schaffer collateral pathway LTP

112 modular design of the laser desorption (LD)-LTP MSI platform, which is mainly assembled from commerc

113 ve tissues, which inspires a broad use of LD-LTP MSI in plant chemistry studies.

114 ies, neurogranin facilitates LTD, but limits LTP by precluding binding of CaMKII with calmodulin.

115 d normal spatial learning in the Barns maze, LTP in hippocampal slices, and expression levels of RyR

116 er during sepsis and inhibited BDNF-mediated LTP.

117 ions suggest that (1) NMDA receptor mediated LTP is observed in nociceptors across both vertebrate an

118 cellular mechanisms of learning and memory (LTP) are already functional in the fetal hippocampus.

119 2019) show that D1-MSN firing induces D2-MSN LTP via the recruitment of cholinergic interneurons.

120 se lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze

121 nabled synaptic potentiation of the normally LTP-resistant synaptic currents in CA2.

122 stimulation of optoFGFR1 partially occluded LTP in a Nlgn1-dependent manner.

123 terruption of the positive feedback cycle of LTP serving as a possible critical early step in preserv

124 we saw no difference in binding or degree of LTP inhibition by either Abeta or tau oligomers between

125 ited Kingdom (UK), with a prior diagnosis of LTP allergy and sensitization to the peach LTP allergen

126 Patients with diagnosis of LTP allergy from the Allergy Unit of Hospital Regional U

127 to be learned regarding the effectiveness of LTP on bacteria in suspension in liquids, and especially

128 key mediators of the bactericidal effects of LTP and hydrogen peroxide is necessary but not sufficien

129 To test this hypothesis, effects of LTP were compared to control stimulation in rat hippocam

130 We investigated the efficacy of LTP treatments against bacteria using an atmospheric-pre

131 eletion of SR resulted in the elimination of LTP at 1 month of age, which could be rescued by exogeno

132 JQ1 reversed RGFP966-induced enhancement of LTP in hippocampal slice preparations.

133 pled receptors promote LTD at the expense of LTP.

134 al period is necessary for the expression of LTP at PV-IN output synapses, involving gene expression

135 o the G-protein Gs promote the expression of LTP at the expense of LTD, and Gq-coupled receptors prom

136 dict the occurrence of long-lasting forms of LTP for multiple experimental protocols.

137 paired-pulse facilitation after induction of LTP in WT males, but not in WT females, possibly related

138 and cholinergic synapses in the induction of LTP to be distinguished.

139 hic factor (BDNF) signaling and induction of LTP.

140 ly to a long-range metaplastic inhibition of LTP in rats.

141 ulation (TBS) and the resulting magnitude of LTP consolidation, both in control conditions and follow

142 revealed significantly reduced magnitude of LTP in MT mice.

143 e importance of CC2D1A in the maintenance of LTP at Schaffer collateral-CA1 synapses and the formatio

144 ce displayed a deficit in the maintenance of LTP in the CA1 region of hippocampal slices.

145 e of these interneurons in the modulation of LTP at Schaffer collateral synapses onto pyramidal cells

146 Interestingly, there was a restoration of LTP by 2 months of age that was associated with an upreg

147 it mitigated the IH-dependent suppression of LTP and prevented adult-born neuron loss.

148 eta-oligomer (Abetao)-induced suppression of LTP in hippocampal slices.

149 also prevents Abetao-induced suppression of LTP in WT slices.

150 that the synaptic modification threshold of LTP and LTD readjusts with activity and thus the outcome

151 r the first-time, the amino acid sequence of LTPs in lentil has been confirmed by high resolution mas

152 dendritic spines, and inhibitory actions on LTP induction, while variant RQ exhibits a mixed phenoty

153 y examines the role that DAGL-alpha plays on LTP in hippocampus, as well as in hippocampal-dependent

154 Hz but vanished >50 Hz or <1 Hz (where only LTP or LTD occurred).

155 ing to LTP-enriched peach SPT reagent and/or LTP allergens in peach, walnut, mugwort and plane tree m

156 witching between DESI, voltage-free EASI, or LTP ionization as well as to freely move the interface o

157 AMPA receptors can determine whether LTD or LTP occurs in cerebellar PCs.

158 required for basal synaptic transmission or LTP, but participates in LTD.

159 OM-INs regulated Schaffer collateral pathway LTP in pyramidal neurons.

160 PF-PC LTP is associated with an increase in the size of the re

161 , whether Epac proteins participate in PF-PC LTP is not known.

162 ic receptors (betaARs) is required for PF-PC LTP, although noradrenergic varicosities are apposed in

163 beta1AR antagonist metoprolol blocked PF-PC LTP, which was also absent in Epac2 (-/-) mice.

164 r activation of these betaARs occluded PF-PC LTP, while the beta1AR antagonist metoprolol blocked PF-

165 in the size of the RRP contributes to PF-PC LTP.SIGNIFICANCE STATEMENT G-protein-coupled receptors m

166 f LTP allergy and sensitization to the peach LTP allergen Pru p 3, were compared to UK subjects with

167 as necessary for learning-induced persistent LTP at excitatory inputs of somatostatin interneurons th

168 onization (EASI) and low-temperature plasma (LTP) ionization are powerful ambient ionization techniqu

169 aluate the effect of low-temperature plasma (LTP) on an anaerobic biofilm and on the biological respo

170 sma medicine applies low-temperature plasma (LTP) physics to address biomedical problems such as woun

171 ionally (3D) printed low-temperature plasma (LTP) probe.

172 Art v 3, a pollen LTP from mugwort, is frequently involved in this cross-r

173 structural epitopes of an allergenic pollen LTP.

174 at occluded presynaptic but not postsynaptic LTP.

175 ion (LTP) was not affected, the postsynaptic LTP of NMDAR-EPSCs was reduced.

176 long-term depression (LTD) and potentiation (LTP) at the PF-PC synapse.

177 spatial memory, and long-term potentiation (LTP) abnormalities in adult mice.

178 of Hebbian forms of long-term potentiation (LTP) and depression (LTD) by affecting cellular and netw

179 ticity, comprised of long-term potentiation (LTP) and depression (LTD), allows neurons to encode and

180 enhanced hippocampal long-term potentiation (LTP) and increased dendritic spine density and synaptic

181 ement of hippocampal long-term potentiation (LTP) and long-term depression (LTD), and for the regulat

182 evel from which both long-term potentiation (LTP) and LTD are possible.

183 is needed to ensure long-term potentiation (LTP) and memory.

184 ies and can modulate long-term potentiation (LTP) and memory.

185 ied by impairment in long-term potentiation (LTP) and spatial learning.

186 ng and impaired both long-term potentiation (LTP) and spatial memory in mice, although endogenous SHP

187 c changes induced by long-term potentiation (LTP) are thought to underlie memory formation.

188 cedure also leads to long-term potentiation (LTP) at an excitatory synapse, derived from the posterom

189 s - the induction of long-term potentiation (LTP) at excitatory, axospinous synapses.

190 he dynamic range for long-term potentiation (LTP) at MPP-GC synapses, an effect requiring Ca(2+) sign

191 Long-term potentiation (LTP) at parallel fiber (PF)-Purkinje cell (PC) synapses

192 ll as a reduction in long-term potentiation (LTP) at the associational-commissural - CA3 synapses.

193 aptic potentials and long-term potentiation (LTP) at the Schaffer collaterals-CA1 synapse.

194 mice displayed a CA1 long-term potentiation (LTP) deficit that was not associated with memory impairm

195 cits and hippocampal long-term potentiation (LTP) impairments without altering brain amyloid beta (Ab

196 APPalpha facilitates long-term potentiation (LTP) in a concentration-dependent fashion through cellul

197 increase in moderate long-term potentiation (LTP) in cocaine-treated rats compared to saline controls

198 oth the induction of long-term potentiation (LTP) in hippocampal CA1 pyramidal cells and hippocampal-

199 ensity, and enhanced long-term potentiation (LTP) in hippocampal neurons.

200 lation (TBS)-induced long-term potentiation (LTP) in hippocampal slices from AS mice by enhancing SK2

201 essed development of long-term potentiation (LTP) in the CA1-subiculum, but not in the CA3-CA1 pathwa

202 In this study, long-term potentiation (LTP) in the CNS of the medicinal leech, Hirudo verbana,

203 olished induction of long-term potentiation (LTP) in the Schaffer collateral pathway of CA1 pyramidal

204 ired for deficits in long-term potentiation (LTP) in transplant recipients, and LTP impairment in TRA

205 GluR1)-mediated late long-term potentiation (LTP) of excitatory input synapses onto hippocampal SOM-I

206 us exhibit a form of long-term potentiation (LTP) of glutamatergic transmission that does not depend

207 Long-term potentiation (LTP) of mature neurons produces synapse enlargement bala

208 ited a novel form of long-term potentiation (LTP) of MNTB-LSO synapses.

209 calmodulin, favoring Long-Term Potentiation (LTP) or Depression (LTD) respectively.

210 llowing induction of long-term potentiation (LTP) or learning.

211 into synapses during long-term potentiation (LTP) or removed during long-term depression (LTD).

212 form of mossy fiber long-term potentiation (LTP) was not affected, the postsynaptic LTP of NMDAR-EPS

213 e its involvement in long-term potentiation (LTP) was shown.

214 hrough potentiation (long-term potentiation (LTP)) or depression (long-term depression (LTD)) as well

215 loss of hippocampal long-term potentiation (LTP), a brain-derived neurotrophic factor-mediated (BDNF

216 dal neurons exhibits long-term potentiation (LTP), a positive feedback process implicated in learning

217 Long-term potentiation (LTP), an increase in synaptic efficacy following high-fr

218 y deficits, abnormal long-term potentiation (LTP), and social and communication deficits.

219 strength and induce long-term potentiation (LTP), does not exclusively recruit glutamatergic axons.

220 enabled induction of long-term potentiation (LTP), expressed mostly postsynaptically and occluded by

221 ic memory mechanism, long-term potentiation (LTP), triggers withdrawal of PAPs from potentiated synap

222 s thought to reflect long-term potentiation (LTP)-like cortical plasticity (n = 32).

223 rtical layers, and a long-term potentiation (LTP)-like enhancement (DCS-LTP) was recorded in deep cor

224 on was used to probe long-term potentiation (LTP)-like plasticity in M1.

225 capacity to inhibit long-term potentiation (LTP).

226 nd memory as well as long term potentiation (LTP).

227 by greatly enhanced long-term potentiation (LTP).

228 n, IH(30) suppressed long-term potentiation (LTP).

229 elevated early-phase long term potentiation (LTP).

230 ical properties, and long-term potentiation (LTP).

231 ic activation, as in long-term potentiation (LTP).

232 y impairing synaptic Long-term potentiation (LTP).

233 , including synaptic long-term potentiation (LTP).

234 m memory and in late long-term potentiation (LTP).

235 apable of expressing long-term potentiation (LTP).

236 sion, suppression of Long-term-Potentiation (LTP), an electrophysiological surrogate of learning and

237 rtion of responders, odds ratios (OR) of pre-LTP factors associated with being a nonresponder.

238 P was 19.1 +/- 5.0 mm Hg, mean number of pre-LTP medications was 2.1 +/- 1.5.

239 rface, where they are positioned for priming LTP.

240 high spike frequencies, neurogranin promotes LTP by enhancing CaMKII autophosphorylation.

241 uropean populations, lipid transfer protein (LTP) allergy is considered to manifest mainly in Mediter

242 y as observed in the lipid transfer protein (LTP) syndrome, which is characterized by severe allergic

243 rent stages, but the lipid transfer protein (LTP)-encoding genes, including SIN_1019175, SIN_1019172

244 Mediterranean area, lipid transfer proteins (LTPs) are important causes of plant-food allergies often

245 , Len c 1.0102, and lipid transfer proteins (LTPs), indicating qualitative and quantitative variation

246 lles (ROs) recruits lipid transfer proteins (LTPs), like oxysterol-binding protein (OSBP).

247 cell adhesion signaling critically regulates LTP.

248 cognitive flexibility dependent on repeated LTP.

249 y drugs reduced brain inflammation, restored LTP and long-term memory, and reversed social and commun

250 ne receptors, was required to restore robust LTP.

251 StudyPopulation: LTP patients in the Intelligent Research in Sight (IRIS)

252 lation in stratum oriens inhibits subsequent LTP in the stratum radiatum of hippocampal area CA1, pot

253 rther that the optogenetic induction of such LTP in vivo facilitates, while optogenetic long-term dep

254 atergic neuronal transmission and suppresses LTP by increasing brain TNF-alpha concentrations, direct

255 ty rules governing the induction of synaptic LTP depend on dendritic location; (2) LTP of input patte

256 to facilitate coincidence detection during t-LTP induction.

257 3 tissue damage enhanced the likelihood of t-LTP generation at sensory synapses onto the mature GABAe

258 e timing-dependent long-term potentiation (t-LTP) in projection neurons predominantly evoked NMDAR-de

259 Together, these findings reveal that LTP at a hypothalamic circuit node mediates a form of ex

260 mp and 3D molecular localization reveal that LTP induction thus prompts spatial retreat of astroglial

261 immunogold electron microscopy revealed that LTP stimulation of the Schaffer collateral pathway promo

262 tmospheric-pressure plasma jet and show that LTP treatments have the ability to inhibit both gram-pos

263 The LTP-triggered PAP withdrawal involves NKCC1 transporters

264 ificant correlations between Pru p 3 and the LTP allergens in peanuts, walnuts, plane tree and mugwor

265 -thalamo-cortical network is altered and the LTP-like plasticity elicited by intermittent theta burst

266 ICANCE STATEMENT In Parkinson's disease, the LTP-like plasticity of the primary motor cortex is impai

267 hylaxis and delayed onset of symptoms in the LTP-monoallergic group (P = .02 and P = .04, respectivel

268 on and induced neuroplasticity mimicking the LTP of EPSPs.

269 ons play a beneficial role in modulating the LTP-like plasticity of M1 in Parkinson's disease.

270 that driving gamma oscillations restores the LTP-like plasticity in patients with Parkinson's disease

271 lettuce and mustard and sensitization to the LTP allergens in peach, walnut, mugwort and plane tree T

272 The trafficking effects, along with the LTP facilitation, persist after sAPPalpha washout, revea

273 t increase in synaptic transmission and this LTP was both NMDA receptor-mediated and synapse-specific

274 t local secretory trafficking contributes to LTP-induced synaptogenesis and primes the new spines for

275 rgic patients in both populations evolved to LTP-Allergy and showed an early onset.

276 , our data suggests that bacteria exposed to LTP do not develop resistance to further treatment with

277 ex differences in kinase signaling extend to LTP.

278 presynaptic activity, which actually led to LTP in PE animals, whereas LTD was still observed in con

279 the 15 UK PFS subjects had a positive SPT to LTP-enriched peach reagent, compared to 91% of the 35 UK

280 Testing to LTP-enriched peach SPT reagent and/or LTP allergens in p

281 animals and to uncover a hippocampal LTD-to-LTP shift.

282 ctors associated with laser trabeculoplasty (LTP) responses.

283 peach reagent, compared to 91% of the 35 UK LTP subjects.

284 The UK LTP cohort were also more likely to have positive skin p

285 (93.2%) had LTP-syndrome and 17 (6.8%) were LTP-monoallergic.

286 on by heterosynaptic metaplasticity, whereas LTP was entirely rescued by incubation with a TNFalpha a

287 Our results support a model in which LTP generates synaptic slots, which capture passively di

288 blocked the spine expansion associated with LTP, as monitored by two-photon imaging; this block invo

289 o be redistributed to synaptic clusters with LTP-related synapse enlargement while homeostatic regula

290 arance times were negatively correlated with LTP magnitude following nonselective glutamate transport

291 spine translocation of MAP2 was coupled with LTP-induced spine enlargement.

292 ed cohort of Italian subjects diagnosed with LTP allergy.

293 This phenomenon shows partial occlusion with LTP induced by electrical stimulation, and is sensitive

294 aimed to characterize adults presenting with LTP allergy in a northern European country.

295 Native UK subjects with LTP allergy are not dissimilar to those with LTP allergy

296 LTP allergy are not dissimilar to those with LTP allergy in southern Europe.

297 develop resistance to further treatment with LTP.

298 r OS (36.7% vs. 44.6%, p = 0.4289) or 5-year LTP (73.3% vs. 67.9%, p = 0.8897) between CT-RFA and L-R

299 sary and sufficient for inducing Z-LTD and Z-LTP.

300 on induced LTP of synaptic zinc signaling (Z-LTP), evidenced by enhanced zinc-mediated inhibition of