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1                                              LXRbeta agonism robustly suppressed tumor growth and met
2                                              LXRbeta gene expression poorly correlates with ABCA1 in
3                                              LXRbeta selectivity was confirmed using macrophages deri
4                                              LXRbeta subsequently modulates signaling by ALK-1 and th
5                                              LXRbeta targeting significantly prolonged animal surviva
6                                              LXRbeta was insensitive to fatty acid regulation in both
7                                              LXRbeta(-/-) mice responded to 24-h dehydration with a d
8                                              LXRbeta-deficient mice crossed to the hyperlipidemic Apo
9                          We propose that (1) LXRbeta and PPARdelta coordinate NPC1L1/ABCA1-dependent
10                       Here, we identify 2035 LXRbeta-RXRalpha binding sites containing 4794 LXR respo
11 ls had increased oxysterols, which activated LXRbeta to upregulate ABCA1.
12 ti-inflammatory activities and, in addition, LXRbeta is involved in the genesis of dopaminergic neuro
13 R modulator GSK9772 ( 20) as a high-affinity LXRbeta ligand (IC 50 = 30 nM) that shows separation of
14 ll agonist selectively kills GBM cells in an LXRbeta- and cholesterol-dependent fashion, causing tumo
15 l receptors LXR (liver X receptor)-alpha and LXRbeta are nuclear receptors that play a key role in re
16             Liver X receptor (LXR) alpha and LXRbeta function as physiological sensors of cholesterol
17 l receptors liver X receptor (LXR) alpha and LXRbeta.
18                           As both ERbeta and LXRbeta are ligand-activated transcription factors, thei
19                              Both ERbeta and LXRbeta have potent anti-inflammatory activities and, in
20  of cofactor peptides onto both LXRalpha and LXRbeta and showed an EC(50) of approximately 2 muM in p
21 here that the nuclear receptors LXRalpha and LXRbeta and their oxysterol ligands are key regulators o
22 eceptors liver X receptor (LXR) LXRalpha and LXRbeta are differentially expressed ligand-activated tr
23               Here we show that LXRalpha and LXRbeta are expressed in both type I and type II mouse l
24 istochemical staining that both LXRalpha and LXRbeta are expressed in the cell nuclei of the epitheli
25  demonstrate here that although LXRalpha and LXRbeta are not required for adipocyte development per s
26  confirmed that 4 binds to both LXRalpha and LXRbeta directly and recruits coactivator peptide SRC-1.
27  derived from mice lacking both LXRalpha and LXRbeta failed to up-regulate the expression of ABC8 fol
28  addressed how deletion of both LXRalpha and LXRbeta from mouse liver (LXR double knockout [DKO]) aff
29           The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of cholester
30           The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of lipogenes
31 of the liver X receptors (LXRs) LXRalpha and LXRbeta in carbohydrate sensing by the liver (see the re
32  confirm an equivalent role for LXRalpha and LXRbeta in the regulation of ABCA1 and SREBP-1c gene exp
33   Desmosterol bound to purified LXRalpha and LXRbeta in vitro and supported the recruitment of steroi
34 at the liver X receptors (LXRs) LXRalpha and LXRbeta inhibit basal and cytokine-inducible expression
35  This increase was blunted when LXRalpha and LXRbeta levels were reduced by siRNAs.
36 h deep sequencing revealed that LXRalpha and LXRbeta occupy both overlapping and exclusive genomic re
37 UMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of
38 dominant negative (DN) forms of LXRalpha and LXRbeta reduced calcium content in CVCs.
39                            Both LXRalpha and LXRbeta transactivated the VEGF promoter in transient tr
40                            Both LXRalpha and LXRbeta were present in VSMC, and their activation with
41 receptor coactivator-1 to human LXRalpha and LXRbeta with EC(50)s of 40 nM, profiles as an LXR agonis
42              Liver X receptors (LXRalpha and LXRbeta) are important regulators of cholesterol and lip
43 ver X receptors alpha and beta (LXRalpha and LXRbeta) are important regulators of cholesterol homeost
44          The liver X receptors (LXRalpha and LXRbeta) are members of the nuclear receptor superfamily
45 ver X receptors alpha and beta (LXRalpha and LXRbeta) are oxysterol-activated transcription factors t
46 entified the liver X receptors (LXRalpha and LXRbeta) as important regulators of cholesterol and lipi
47  role of the liver X receptors (LXRalpha and LXRbeta) in preventing accumulation of free cholesterol
48 red that the Liver-X-Receptors (LXRalpha and LXRbeta), nuclear receptors known to regulate lipid meta
49 iver X receptors alpha and beta(LXRalpha and LXRbeta), which are important in regulating not only lip
50 ver X receptors alpha and beta (LXRalpha and LXRbeta).
51 is lost in animals lacking both LXRalpha and LXRbeta, confirming the critical role of these receptors
52 oxidized lipids, which activate LXRalpha and LXRbeta, resulting in the induction of ABCA1, ABCG1, and
53            Here, we report that LXRalpha and LXRbeta, two orphan members of the nuclear receptor supe
54               Plaques from both LXRalpha and LXRbeta-deficient Apoe-/- mice exhibited impaired regres
55 ct, PARP-1 interacted with both LXRalpha and LXRbeta.
56 iring the participation of both LXRalpha and LXRbeta.
57 eptors liver X receptor alpha (LXRalpha) and LXRbeta function as physiological receptors for oxidized
58 iver X receptor alpha (LXRalpha) (NR1H3) and LXRbeta (NR1H2) are important regulators of genes involv
59 ear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of
60  The liver X receptors, LXRalpha (NR1H3) and LXRbeta (NR1H2), are ligand-activated transcription fact
61 ective agonist for both LXRalpha (NR1H3) and LXRbeta (NR1H2).
62 re Fugu orthologs, excepting CAR (NR1I3) and LXRbeta (NR1H2).
63                   Both LXRalpha/RXRalpha and LXRbeta/RXRalpha transactivated the CETP promoter via it
64                                  TRalpha and LXRbeta bind to identical response elements on DNA and s
65                               In both WT and LXRbeta(-/-) mice, expression of TRalpha was high at pos
66  the same degree of potency as 22R-HC (3) at LXRbeta, while it was virtually inactive at LXRalpha (EC
67 t, orally efficacious liver X receptor beta (LXRbeta) agonist (17).
68 lear receptor family, liver X receptor beta (LXRbeta) and thyroid hormone receptor alpha (TRalpha), h
69  the nuclear receptor liver X receptor beta (LXRbeta) as a modulator/mediator of ALK-1 signaling.
70 udies have implicated liver X receptor beta (LXRbeta) in key neurodevelopmental processes and neurode
71 he oxysterol receptor liver X receptor beta (LXRbeta) in the etiology of diabetes insipidus (DI).
72                       Liver X receptor beta (LXRbeta) is a member of the nuclear receptor super gene
73 creased expression of liver X receptor beta (LXRbeta), a nuclear receptor that controls cellular lipi
74 the nuclear receptor, liver X receptor beta (LXRbeta), had an adverse effect on progression of the di
75 ncrease and activates liver X receptor beta (LXRbeta), promoting cholesterol release from lysosomes a
76 tor beta (ERbeta) and liver X receptor beta (LXRbeta).
77 athway activation in macrophages achieved by LXRbeta and endogenous ligand is unable to maintain home
78 nts revealed these effects to be mediated by LXRbeta, which elicits these outcomes through transcript
79  female mice, we found that LXRs, especially LXRbeta, also repress the browning process of subcutaneo
80 ated transcriptional responses, establishing LXRbeta as a potential modulator/mediator of ALK-1/ALK-2
81 ction in all members of the NR family except LXRbeta suggests a functional role for the intron.
82 gnition tests to evaluate behavior in female LXRbeta KO (LXRbeta(-/-)) mice.
83 lude that the anxiogenic phenotype in female LXRbeta(-/-) mice is caused by reduced GABAergic input f
84                     We found that the female LXRbeta(-/-) mice were anxious with impaired behavioral
85 ompounds displayed good binding affinity for LXRbeta and LXRalpha and were potent activators in LBD t
86 Compound 13 demonstrated partial agonism for LXRbeta in kidney HEK-293 cells but did not activate Gal
87           Our data establish novel roles for LXRbeta in adipocyte growth, glucose homeostasis, and be
88 ignificantly decreased in skin isolated from LXRbeta-null mice.
89 dney HEK-293 cells but did not activate Gal4 LXRbeta fusion proteins in huh-7 liver cells.
90  skin, we mapped its cistrome by identifying LXRbeta-RXRalpha binding sites using ChIP-on-chip in nor
91                                 Importantly, LXRbeta activation displayed melanoma-suppressive cooper
92                                           In LXRbeta(-/-) mice the expression of AVP was markedly dec
93 imilar food intake and oxygen consumption in LXRbeta-/- mice suggests that reduced storage of lipid i
94 dition, 22ROH did not reduce inflammation in LXRbeta-/- or LXRalphabeta-/- animals, indicating that L
95 nserved lysine (K432 in LXRalpha and K433 in LXRbeta) adjacent to the ligand-regulated activation dom
96 ER2) (the reelin receptor) was much lower in LXRbeta(-/-) than in WT mice.
97  retarded migration of later-born neurons in LXRbeta(-/-) mice but that as thyroid hormone (TH) incre
98 there is reduced OPC production from RGCs in LXRbeta(-/-) mice.
99 s to evaluate behavior in female LXRbeta KO (LXRbeta(-/-)) mice.
100                                 Mice lacking LXRbeta exhibit lymphoid hyperplasia and enhanced respon
101  the two isoforms of Liver X receptor (LXR), LXRbeta has been shown to have major effects in the cent
102                               LXRalpha(-/-), LXRbeta(-/-), and LXRalpha/beta(-/-) mice developed acel
103 the LXR agonist GW3965 and in LXRalpha(-/-), LXRbeta(-/-), and LXRalpha/beta(-/-) mice.
104                                    LXRalpha, LXRbeta, ATP-binding cassette transporter A1 (ABCA1), an
105 and T0901317 required PPARalpha and LXRalpha/LXRbeta for statistical significance.
106 es from the livers of wild-type and LXRalpha/LXRbeta-null mice after exposure to the LXR agonist N-(2
107 r receptors, the liver X receptors (LXRalpha/LXRbeta), protects against atherosclerosis by transcript
108                      In the brain of WT mice LXRbeta was expressed in the nuclei of magnocellular neu
109 heral tissues from these LXRalpha-null mice, LXRbeta activation increases ABCA1 and SREBP-1c gene exp
110 al docking studies using GLIDE with modified LXRbeta ligand-binding domain (LBD) on internal compound
111                 However, genetic ablation of LXRbeta in T cells did not revert the effects of NCOR1 d
112                                Activation of LXRbeta and/or PPARdelta in cholangiocytes induces ATP-b
113 XR activation promoted the direct binding of LXRbeta to the ligand-binding domain of ERalpha and init
114  knockout mice to assess the contribution of LXRbeta to the regulation of selected target genes.
115 normalities were detectable in the cortex of LXRbeta(-/-) mice and ApoER2 expression was much stronge
116  still abundantly expressed in the cortex of LXRbeta(-/-) mice.
117 myelination, and point to the involvement of LXRbeta in psychiatric disorders.
118 n in aquaporin-1 expression in the kidney of LXRbeta(-/-) mice.
119      Cells with CRISPR-mediated knockdown of LXRbeta, but not ABCA1, had decreased cell cycle progres
120 ts mitogen-driven expansion, whereas loss of LXRbeta confers a proliferative advantage.
121            Here, we demonstrate that loss of LXRbeta function leads to abnormality in locomotor activ
122 ocytes was higher in the substantia nigra of LXRbeta(-/-) mice than in WT littermates.
123 aminergic neurons of the substantia nigra of LXRbeta(-/-) mice were much more severely affected by MP
124 t results in the specific phosphorylation of LXRbeta by ALK-1, primarily on serine residues.
125 th IL-1beta, indicating a protective role of LXRbeta in cartilage.
126                          The in vivo role of LXRbeta in liver was further evaluated by treating LXRal
127         Starting with a crystal structure of LXRbeta and a docked 2-(methylsulfonyl)benzyl alcohol fr
128               Thus, therapeutic targeting of LXRbeta in glioblastoma might be effective through diver
129  activated ALK-1 results in translocation of LXRbeta from the nuclear compartment to the cytoplasmic
130 del of PD to investigate the possible use of LXRbeta as a target for prevention or treatment of PD.
131  to potency and efficacy on LXRalpha than on LXRbeta.
132 crophages, whereas expression of LXRalpha or LXRbeta was similar.
133 oe-/- mice with BM deficiency of LXRalpha or LXRbeta, into WT recipients.
134 hion when cotransfected with LXRalpha/RXR or LXRbeta/RXR.
135 pairs) as a binding site for LXRalpha/RXR or LXRbeta/RXR.
136 ble, highly brain-penetrant LXRalpha-partial/LXRbeta-full agonist selectively kills GBM cells in an L
137 nuclear receptors, some of which (PPARalpha, LXRbeta) regulate specific liver gene expression network
138 tion independent from its ability to repress LXRbeta-induced gene expression.
139 t required for adipocyte development per se, LXRbeta is required for the increase in adipocyte size t
140                        In summary, selective LXRbeta activation is expected to stimulate ABCA1 gene e
141 e that it is possible to achieve significant LXRbeta selectivity in a small molecule while maintainin
142                                Surprisingly, LXRbeta was not expressed in the neurons of the substant
143 rt for drug development strategies targeting LXRbeta.
144 endent more on the presence of LXRalpha than LXRbeta.
145               These studies demonstrate that LXRbeta has nonnuclear function in EC caveolae/lipid raf
146  endothelial cells (ECs) and discovered that LXRbeta has nonnuclear function and stimulates EC migrat
147 optic nerve, providing in vivo evidence that LXRbeta deletion delays both oligodendrocyte differentia
148  or LXRalphabeta-/- animals, indicating that LXRbeta is required for this anti-inflammatory effect.
149                Further studies revealed that LXRbeta and ERalpha are colocalized and functionally cou
150  and lipidomics analyses cells revealed that LXRbeta regulates the expression of immune response gene
151 alysis of islet gene expression reveals that LXRbeta is required for expression of the cholesterol tr
152     Collectively, these results suggest that LXRbeta, by driving RGCs to become OPCs in the dorsal co
153 ncrease in urine osmolality, suggesting that LXRbeta is a key receptor in controlling water balance w
154       Cholesterol-efflux studies verify that LXRbeta can drive apoA1-dependent cholesterol mobilizati
155 eceptor (LXR) agonist (2) that activates the LXRbeta subtype with selectivity over LXRalpha.
156  in NHEKs, demonstrating that 77% of all the LXRbeta-RXRalpha binding regions show the presence of AP
157 , 22, and 25 showed good selectivity for the LXRbeta isoform.
158 NS phenotype is much more severe than in the LXRbeta ko mice, suggesting a contribution of LXRalpha i
159   The reason for the migration defect in the LXRbeta(-/-) mouse and the possibility that TRalpha may
160 A comparison with existing structures of the LXRbeta homodimer and LXRalpha:RXR (retinoid X receptor)
161 cis-regulatory motifs in the vicinity of the LXRbeta-RXRalpha binding sites.
162   Despite reduced amounts of adipose tissue, LXRbeta-/- mice on a chow diet have insulin sensitivity
163 lthough 13 showed potent binding affinity to LXRbeta (IC(50) = 53 nM), it had little binding affinity
164                  An i.p. injection of AVP to LXRbeta(-/-) mice revealed a partial kidney response: Th
165  region of the human C3 gene, which binds to LXRbeta in macrophages but not in HepG2 cells.
166 lasmic domain of ALK-1 specifically binds to LXRbeta in vitro and in vivo.
167                         Compound 17 binds to LXRbeta with high affinity and to LXRalpha to a lesser e
168  the structurally related analog 19 bound to LXRbeta reveals regions within the receptor that can aff
169 ated carotid artery reendothelialization via LXRbeta- and ERalpha-dependent processes.
170 LXR overexpression by VP16-LXRalpha and VP16-LXRbeta accelerated mineralization of CVCs.
171                  Given free access to water, LXRbeta(-/-) but not LXRalpha(-/-) mice exhibited polyur
172      The interaction of activated ALK-1 with LXRbeta in the cytoplasmic compartment results in the sp
173  and -beta) are expressed in cartilage, with LXRbeta being the predominant isoform.

 
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