ライフサイエンスコーパス: Langendorff

1 Langendorff LV performance was examined during isoproter

2 Langendorff perfused hearts were subjected to 20 minutes

3 Langendorff perfusion also indicated that mutant phospho

4 Langendorff perfusion indicated that the basal hyperdyna

5 Langendorff-perfused adult Sprague-Dawley rat hearts wer

6 Langendorff-perfused hearts from TG (n=6) and wild-type

7 Langendorff-perfused hearts underwent 1 h of regional is

8 Langendorff-perfused hearts were assessed for atrial eff

9 Langendorff-perfused hearts were subjected to various pe

10 Langendorff-perfused isolated rat hearts were subjected

11 Langendorff-perfused isolated rat hearts were subjected

12 Langendorff-perfused mouse hearts were treated by triton

13 Langendorff-perfused mutant hearts also demonstrated dep

14 Langendorff-perfused rat hearts treated with EPO exhibit

15 Langendorff-perfused rat hearts were preconditioned with

16 Langendorff-perfused rat hearts were subjected to 40 min

17 Langendorff-perfused rat hearts were subjected to 40 min

18 Langendorff-perfused rat hearts were subjected to 40-min

19 Langendorff-perfused rat hearts were subjected to the Ca

20 In 10 Langendorff-perfused rabbit hearts, monophasic and bipha

21 -threshold atrial shocks was performed in 12 Langendorff-perfused sheep hearts.

22 In 13 Langendorff-perfused sheep hearts, AF was induced in the

23 empted defibrillation episodes (n=173) in 17 Langendorff-perfused rabbit ventricles.

24 during 6-ms MW and 3-ms/3-ms BW shocks in 19 Langendorff-perfused rabbit ventricles.

25 f this effect of defibrillation shocks in 23 Langendorff-perfused rabbit hearts by optically mapping

26 ular action potentials were recorded from 26 Langendorff-perfused guinea pig hearts in the absence (i

27 From 3 Langendorff-perfused pig hearts, 180 intramural unipolar

28 of propagation during 20 episodes of AF in 6 Langendorff-perfused sheep hearts.

29 of 0.1 to 0.5 micromol/L acetylcholine in 7 Langendorff-perfused sheep hearts.

30 Twenty-four VF episodes from 8 Langendorff-perfused rabbit hearts were studied using hi

31 ternans on the surface ECG was elicited in 8 Langendorff-perfused guinea pig hearts during fixed-rate

32 ed from 128 ventricular sites (1 cm(2)) in 8 Langendorff-perfused guinea pig hearts.

33 usly from 128 ventricular sites (1 cm2) in 8 Langendorff-perfused guinea pig hearts.

34 Combining a Langendorff heart model of low-flow ischaemia/reperfusio

35 1-/- and wild-type hearts were perfused in a Langendorff apparatus in both the absence and presence o

36 Rabbit hearts were perfused in a Langendorff apparatus with full sympathetic and parasymp

37 emia/reperfusion, which was carried out in a Langendorff isolated perfused heart model (n=8 to 9 per

38 reperfusion reduced infarct size by 60% in a Langendorff isolated perfused rat heart model, and that

39 ed to hypoxia/reoxygenation, as well as in a Langendorff model of myocardial ischemia.

40 ro-flow global ischemia and reperfusion in a Langendorff model.

41 ischemia followed by 60 min reperfusion in a Langendorff model.

42 rom 4 (30-40 kg) pigs and were perfused in a Langendorff organ bath.

43 uction in cardiac function was observed in a Langendorff perfusion system.

44 mouse hearts were retrogradely perfused in a Langendorff preparation, and electrocardiograms were rec

45 d were subjected to I/R (25 min/60 min) in a Langendorff preparation.

46 h ethanol-free buffer prior to ischemia in a Langendorff preparation.

47 Six excised dog hearts were perfused in a Langendorff preparation.

48 tects the heart from reperfusion injury in a Langendorff setting.

49 rom the screen were subsequently tested in a Langendorff-perfused heart model of IR injury, revealing

50 or LC (100 microgram/mL) was infused into a Langendorff-perfused, isovolumically contracting mouse h

51 By use of a Langendorff preparation, hearts from transgenic mice sho

52 er surgery, hearts were either perfused on a Langendorff apparatus for 30 minutes at 37 degrees C (pr

53 rgery, transfected hearts were perfused on a Langendorff apparatus for 45 minutes, arrested with St T

54 Adult rat hearts perfused on a Langendorff apparatus were subjected to ischemia or isch

55 re perfused with Krebs-Henseleit buffer on a Langendorff apparatus.

56 5 minutes or 4 hours before reperfusion on a Langendorff apparatus.

57 blood flow in isolated hearts perfused on a Langendorff apparatus.

58 9 out of 21 days of incubation) mounted on a Langendorff preparation were exposed to IR (30 min ischa

59 t, the heart was isolated and mounted onto a Langendorff preparation.

60 Using a Langendorff perfused rat heart, we show that the acetylc

61 Using a Langendorff perfusion model and an intraventricular ball

62 osure, we assessed cardiac responses using a Langendorff preparation in a protocol consisting of 20 m

63 Using a Langendorff preparation, one group of isolated rabbit he

64 138 dG, isolated hearts were studied using a Langendorff preparation.

65 Using a Langendorff rat heart perfusion protocol, we observed ag

66 ly sorted human leukocytes/macrophages after Langendorff perfusion of three fetal hearts dying with C

67 tile function in isolated cardiomyocytes and Langendorff-perfused hearts.

68 y internalized in cardiomyocyte cultures and Langendorff-perfused hearts.

69 Echocardiography and Langendorff perfusion demonstrated that cell implantatio

70 unction was examined by echocardiography and Langendorff-perfused isolated heart preparation, whereas

71 iphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft e

72 ure development in isolated myofilaments and Langendorff-perfused hearts, respectively.

73 hearts were assessed under both Working and Langendorff preparations.

74 nhibitor (digoxin or acriflavine) 4 h before Langendorff perfusion resulted in loss of IPC, as did ad

75 For both Langendorff-perfused hearts, the calculated epicardial a

76 Endothelial function was assessed by Langendorff preparations at 1, 2, and 4 weeks.

77 splant recipients with DCM were supported by Langendorff perfusion and were mapped during VF.

78 ucose uptake using isometrically contracting Langendorff-perfused hearts from normal mice (C57BL/6J),

79 which we substantiated using the lower-cost Langendorff-perfused rabbit heart model.

80 two-dimensional preparations of cryoablated Langendorff-perfused rabbit hearts.

81 -alpha (ELISA) and function were determined (Langendorff).

82 f constant flow) or decreased coronary flow (Langendorff constant pressure), which was also observed,

83 2SO4 saturation of perfusates collected from Langendorff rat heart preparations optimally precipitate

84 tly using mitochondria rapidly isolated from Langendorff-perfused hearts.

85 epicardial monophasic action potentials from Langendorff-perfused murine KCNE1-/- hearts for the firs

86 TMRM fluorescence (FTMRM) was recorded from Langendorff-perfused rabbit hearts immobilized with bleb

87 e in situ imaging of T-tubule structure from Langendorff-perfused intact hearts with laser scanning c

88 and preserved cardiac physiologic function (Langendorff preparation).

89 our hrs postburn, left ventricular function (Langendorff), cardiomyocyte [Ca2+]i and [Na+]i measured

90 ing a blood-perfused parabiotic rabbit heart Langendorff model, myocardial oxygen consumption (MVO2)

91 and developed pressure in isolated rat heart Langendorff preparations without affecting diastolic pre

92 n was determined in isolated beating hearts (Langendorff preparation).

93 into the left ventricles of isolated hearts (Langendorff model), and in vitro measurement of Ca2+ tra

94 murine cardiomyocytes and adult rat hearts (Langendorff preparation) mitochondrial fragmentation and

95 tolic pressure, 4+/-1 versus 23+/-1.6 mm Hg; Langendorff LV developed pressure, 105+/-4 versus 62+/-9

96 ath was not observed in young pigs; however, Langendorff-perfused SCN5A(E558X/+) hearts had an increa

97 PLM(3SA)), ouabain-treated and hypertrophied Langendorff-perfused mouse hearts are studied by (23)Na,

98 In Langendorff hearts, Mdivi-1 reduced mitochondrial reacti

99 In Langendorff perfused hearts, atrial conduction was studi

100 In Langendorff-perfused guinea pig hearts, mast cell degran

101 In Langendorff-perfused hearts, baseline atrial ERP was pro

102 In Langendorff-perfused hearts, the functional recovery dur

103 In Langendorff-perfused hearts, there were no differences i

104 In Langendorff-perfused isolated hearts, GSNO pretreatment

105 In Langendorff-perfused mouse heart preparations, Cx43/beta

106 In Langendorff-perfused rat hearts, both Ser(1674) and Ser(

107 f in vivo atrioventricular node ablation, in Langendorff-perfused porcine hearts, using a scanned 12C

108 pwise pacing was used to induce alternans in Langendorff-perfused guinea pig hearts from which optica

109 Left ventricular function analysis in Langendorff perfused hearts and closed-chest anesthetize

110 Titin properties were analyzed in Langendorff-perfused mouse hearts after 20-minute ischem

111 sion proteins for use in cell culture and in Langendorff perfusion of adult rat hearts.

112 l matrix of isolated cardiac myocytes and in Langendorff-perfused hearts based on the use of the redo

113 e evaluated by echocardiography, ECG, and in Langendorff-perfused hearts.

114 the EGSH in isolated cardiac myocytes and in Langendorff-perfused hearts.

115 peptide in isolated cardiac myocytes and in Langendorff-perfused mouse hearts.

116 the mechanism of ventricular arrhythmias in Langendorff-perfused whole heart preparations from homoz

117 nsmembrane potential and intracellular Ca in Langendorff-perfused canine AVJ preparations that did no

118 autophosphorylation of Thr287-CaMKIIdelta in Langendorff hearts and inhibited CaMKIIdelta-dependent R

119 of flecainide and quinidine were compared in Langendorff-perfused wild-type (WT), and genetically mod

120 VFT was determined in Langendorff perfused rat hearts by burst pacing until su

121 activity of the compounds was determined in Langendorff preparations of guinea pig hearts to assess

122 schemia-reperfusion injury was determined in Langendorff-perfused hearts isolated from wild-type mice

123 of propranolol (0.3 mg/L) on VF dynamics in Langendorff-perfused rabbit hearts.

124 Long-duration VF was induced electrically in Langendorff-perfused rabbit hearts (n=22) and terminated

125 ophasic action potential (MAP) electrodes in Langendorff-perfused murine hearts whether under normoka

126 and shows fast recovery of heart function in Langendorff assay.

127 ks were delivered from a bipolar ICD lead in Langendorff-perfused rabbit hearts.

128 a was induced by coronary artery ligation in Langendorff-perfused rabbit hearts, with mechanical load

129 We conducted epicardial mapping in Langendorff-perfused hearts, patch-clamp studies, gene e

130 on in vivo and epicardial voltage mapping in Langendorff-perfused hearts, we demonstrated that focal

131 electric measurements and optical mapping in Langendorff-perfused hearts.

132 ance and calcium transients were measured in Langendorff-perfused hearts and isolated cardiac myocyte

133 perfusates containing 145 or 155 mM Na(+) in Langendorff perfused isolated rat heart preparations.

134 alcium pool, were performed using 19F NMR in Langendorff perfused rabbit hearts loaded with acetoxyme

135 Coronary artery occlusion in Langendorff perfused hearts from transgenic mice resulte

136 MPTP opening in Langendorff-perfused rat hearts was determined by perfus

137 formed during sustained AF (burst pacing) in Langendorff-perfused HF (n=7, 4 micromol/L acetylcholine

138 depressed cardiac contractile parameters in Langendorff-perfused hearts or in vivo.

139 al and intracellular Ca(2+) was performed in Langendorff-perfused rabbit hearts (n = 15).

140 Ca(2+)]SR (with Fluo-5N AM) was performed in Langendorff-perfused rabbit hearts.

141 lation (VF) optical mapping was performed in Langendorff-perfused Sprague-Dawley rat hearts (n=18), w

142 om 8- and 24-month-old rats were perfused in Langendorff fashion and subjected to periods of ischemia

143 Rat hearts were perfused in Langendorff fashion for 60 min (control) or for 30 min f

144 our hours later, the hearts were perfused in Langendorff mode and subjected to 30 minutes of global i

145 ty-four hours later, hearts were perfused in Langendorff mode and subjected to 30 minutes of ischemia

146 0-day-old) rats were aerobically perfused in Langendorff mode before a PC stimulus of either (1) 3-mi

147 of Cys-119/Cys-162 by NO2-OA pretreatment in Langendorff-perfused murine hearts prevented the p38-MKK

148 eloped pressure and rate pressure product in Langendorff mode.

149 in the antiarrhythmic concentration range in Langendorff hearts and isolated rat ventricular myocytes

150 assess wavelength changes with heart rate in Langendorff-perfused wild-type (WT) and Scn5a(+/-) heart

151 s rhythm was similar to patterns recorded in Langendorff-perfused hearts.

152 re, intra-coronary infusion of sildenafil in Langendorff-isolated mouse hearts prior to ischemia-repe

153 simultaneously from 128 ventricular sites in Langendorff-perfused hearts (n = 15) in which propagatio

154 cytes near the adenovirus-injection sites in Langendorff-perfused intact working hearts using confoca

155 technique in establishing single-cell SL in Langendorff-perfused hearts loaded with the membrane dye

156 cardiac myofibrillar proteins was studied in Langendorff-perfused hearts.

157 Studies in Langendorff heart preparations from mutant TR-beta(1) tr

158 S) technique assessed arrhythmic tendency in Langendorff-perfused wild-type (WT) and genetically modi

159 Ex vivo actions were tested in Langendorff hearts and effects on Ca(2+) homeostasis exa

160 nerve stimulation (SNS) in fully innervated, Langendorff-perfused rabbit and mouse hearts.

161 ed in situ myocyte Ca(2+) dynamics in intact Langendorff-perfused hearts (ex vivo) from wild-type and

162 icardial and endocardial surfaces of intact, Langendorff-perfused Scn5a+/Delta hearts.

163 pecies-matched cells directly delivered into Langendorff-perfused porcine hearts or administered perc

164 Before 20 minutes of global ischemia, Langendorff-perfused rat hearts were perfused for 20 min

165 posome (CSIL) treatment of globally ischemic Langendorff instrumented hearts and a time response to t

166 Isolated Langendorff-perfused hearts from these myopathic animals

167 Isolated Langendorff-perfused rat hearts were subjected to perfus

168 In 11 isolated Langendorff-perfused rabbit hearts, monophasic action po

169 In 16 isolated Langendorff-perfused rabbit hearts, the interatrial sept

170 tion at 20 weeks of age (DCM) on an isolated Langendorff apparatus.

171 f episodes of global ischemia in an isolated Langendorff heart.

172 Using an isolated Langendorff perfused rabbit heart model, we subjected he

173 d by echocardiographic analyses and isolated Langendorff heart preparations.

174 rite as a cardioprotective agent in isolated Langendorff mouse heart preparations exposed to I/R.

175 Similarly, in isolated Langendorff perfused hearts of HSP70-positive and transg

176 bolished atrial T-wave alternans in isolated Langendorff perfused hearts.

177 pped using voltage-sensitive dye in isolated Langendorff-perfused hearts along with single glass-micr

178 development and pressure decline in isolated Langendorff-perfused hearts compared with saline-treated

179 rmed optical mapping experiments in isolated Langendorff-perfused rabbit hearts in which alternans wa

180 ation experiments were conducted in isolated Langendorff-perfused rat hearts and coronary-perfused pi

181 In isolated Langendorff-perfused rat hearts, CK inhibition increased

182 Treatment of isolated Langendorff rat hearts with a 12-LOX/AA cocktail signifi

183 right and left atrial appendages of isolated Langendorff-perfused murine hearts.

184 ty at discrete epicardial layers of isolated Langendorff-perfused rabbit hearts to a depth of 500 mum

185 ration, hearts were perfused in the isolated Langendorff mode.

186 This study adapted the isolated Langendorff preparation to study the chicken embryo hear

187 locked by Ba(2+) and ouabain in the isolated Langendorff rat heart.

188 ives of this work were to adapt the isolated Langendorff technique using the chicken embryo to study

189 as a mechanism of VF and VT in the isolated Langendorff-perfused rabbit heart in the absence of an e

190 METHODS AND We used isolated Langendorff-perfused hearts from control (CTL) and heart

191 Isolated, Langendorff-perfused sheep hearts were optically mapped.

192 We studied 7 isolated, Langendorff-perfused canine left atrial (LA) and PV prep

193 ing of the epicardial surface in 8 isolated, Langendorff-perfused rabbit hearts.

194 In isolated, Langendorff-perfused rabbit hearts, optical mapping reve

195 d pacing studies were performed on isolated, Langendorff-perfused rat hearts to assess cardiac electr

196 Studies were performed with isolated, Langendorff-perfused rabbit hearts.

197 lume relationship measured by the isovolumic Langendorff technique showed a progressive rightward shi

198 tabolite profiles obtained from ex vivo mice Langendorff-heart preparations perfused with glucose.

199 P) was initiated in a nonworking heart mode (Langendorff).

200 In modified Langendorff perfusions, ERAs (BQ-123 and bosentan 10(-7,

201 dtype and M2 or M1/3-receptor knockout mouse Langendorff hearts, atropine led to increased contractil

202 g cardiac workload in beating and nonbeating Langendorff perfusions had no effect on the calculated H

203 This study used a novel Langendorff, biventricular, ovine fetal heart preparatio

204 a-reperfusion, but not by ischemia alone, of Langendorff-perfused hearts from wild-type and p53 knock

205 ischemic myocardium, the glycogen content of Langendorff-perfused rat hearts was either depleted or e

206 tial duration from ventricular epicardium of Langendorff-perfused guinea pig hearts at baseline (pH 7

207 Dual voltage- and Ca(2+)-optical mapping of Langendorff-perfused hearts demonstrated that empagliflo

208 ultaneous voltage-calcium optical mapping of Langendorff-perfused SHR hearts revealed that H2 O2 -ind

209 Pretreatment of Langendorff perfused transgenic hearts with the iPLA2 me

210 d to measure the ionized [Ca2+] in the SR of Langendorff-perfused rabbit hearts.

211 al activity from the entire outer surface of Langendorff-perfused hearts.

212 ial (n=14) or endocardial (n=14) surfaces of Langendorff-perfused rabbit ventricles.

213 the surface of the left ventricular wall of Langendorff-perfused isolated rabbit hearts.

214 Animal experiments on Langendorff-perfused rabbit hearts demonstrate the key f

215 e right and left ventricles was performed on Langendorff perfused hearts.

216 ptical mapping experiments were performed on Langendorff rabbit hearts stained with ICG and perfused

217 est left ventricular (LV) catheterization or Langendorff perfusion studies.

218 ffects of Ang II in isolated buffer-perfused Langendorff feline hearts.

219 tyl penicillamine (SNAP), in buffer-perfused Langendorff hearts.

220 from ischemia-reperfusion (isolated perfused Langendorff model) were measured.

221 f myocardial stretch in an isolated perfused Langendorff preparation by inflation of an intraventricu

222 PCR, patch clamp, ex vivo coronary perfusion Langendorff heart experiments, and endothelial cell Ca(2

223 picardial mapping was conducted in a porcine Langendorff model following the topical application of l

224 were preceded by increased aortic pressure (Langendorff constant flow) or decreased coronary flow (L

225 with yields comparable to those in published Langendorff-based methods, using direct needle perfusion

226 1b antiarrhythmic, mexiletine, using the rat Langendorff preparation.

227 cells isolated from an ischemia/reperfusion Langendorff model perfused with oxygenated blood from an

228 Rat hearts were perfused in a retrograde Langendorff system, and the changes in extracellular Mg(

229 the heart was rapidly excised for retrograde Langendorff perfusion.

230 Similarly, Langendorff perfused hearts indicated exacerbated postis

231 etrograde aortic perfusion using specialized Langendorff apparatus, which poses considerable logistic

232 ventricular (LV) working hearts (LWHs) than Langendorff (LANG) perfused hearts.

233 es (WP), muscle myograph baths (MB), and the Langendorff perfused heart apparatus (LPH).

234 ns in primary cardiac myocytes (CMs) and the Langendorff-perfused intact heart.

235 Isolated hearts were perfused by the Langendorff method and were exposed to ischemia, hypoxia

236 ed rat hearts were perfused initially by the Langendorff mode with Krebs-Henseleit buffer (KHB) for 1

237 Hearts were perfused by the Langendorff mode, and after 20 minutes of stabilization

238 ock in the human fetal heart perfused by the Langendorff technique and inhibit L-type Ca2+ currents a

239 Combining the Langendorff method of isolated rat heart perfusion with

240 mals before the removal of the heart for the Langendorff procedure.

241 matched control rabbits were perfused in the Langendorff mode and subjected to 45 minutes of ischemia

242 arts from C57BL/6J mice were perfused in the Langendorff mode and subjected to the following conditio

243 th bicarbonate buffer at 39 degrees C in the Langendorff mode at a constant pressure.

244 from Sprague-Dawley rats and perfused in the Langendorff mode with Krebs-Henseleit solution under the

245 mg/kg IP) 24 hours before global I-R in the Langendorff mode.

246 In the Langendorff model sulindac provided significant protecti

247 Ang-(1-9) increased contraction in the Langendorff model through a protein kinase A-dependent m

248 atine kinase release and infarct size in the Langendorff model.

249 r(tm1Unc)-TgN 1Jaw) mice and perfused in the Langendorff or working-heart mode.

250 tes compared with untreated cells and in the Langendorff perfused ex vivo heart.

251 activation of PKCepsilon in vitro and in the Langendorff perfused ex vivo heart.

252 naesthesia, fetal hearts were mounted in the Langendorff preparation, allowing measurement of left ve

253 d rat hearts were perfused for 10 min in the Langendorff-mode with Krebs-Henseleit buffer in the abse

254 ata derived from a model of stable VF in the Langendorff-perfused guinea pig heart that demonstrates

255 xperiments using a potentiometric dye in the Langendorff-perfused guinea pig heart.

256 Activation patterns of VF in the Langendorff-perfused rabbit heart were studied with the

257 pathways involved in this activation in the Langendorff-perfused rat heart.

258 tion on the surface of the ventricles in the Langendorff-perfused sheep heart.

259 ctivation on the surface of the atria in the Langendorff-perfused sheep heart.

260 al activity on the epicardial surface of the Langendorff-perfused adult mouse heart.

261 he epicardial and endocardial surface of the Langendorff-perfused rabbit heart.

262 on on the surface of the right atrium of the Langendorff-perfused sheep heart during pacing, atrial f

263 f nonarrested hearts acutely perfused on the Langendorff apparatus.

264 two different methods of heart removal: the Langendorff heart method (reverse aortic perfusion) and

265 ardial surface in ventricles showed that the Langendorff-perfused TG hearts were able to sustain stab

266 oncentrated in the myocardium and, using the Langendorff model, to be effective in improving both car

267 -flow I/R (45 minutes/120 minutes) using the Langendorff preparation.

268 Isolated rat hearts were perfused via the Langendorff method under a constant flow of Krebs-Hensel

269 mice and wild-type controls perfused via the Langendorff mode were subjected to 30 minutes of ischemi

270 n embryo heart is amenable for study via the Langendorff preparation under basal conditions and durin

271 y of the left ventricles determined with the Langendorff ex vivo model of ischemia/reperfusion.

272 at hearts were crystalloid perfused with the Langendorff method and subjected to global, normothermic

273 ere subjected to global no-flow I/R with the Langendorff system.

274 Thirty Langendorff-perfused sheep hearts were exposed to acute

275 gf-1(+/-)) transgenic mice were subjected to Langendorff perfusions and progressive periods of ischem

276 Compared with control hearts, transgenic Langendorff-perfused hearts had a significantly lower in

277 Four weeks after transplantation, Langendorff perfusion demonstrated that both maximum dP/

278 An experimental beating-heart model used Langendorff-perfused, healthy swine hearts.

279 Functional assessments using Langendorff preparations and (13)C nuclear magnetic reso

280 s were studied in the absence of blood using Langendorff preparations.

281 gram data from 7 isolated human hearts using Langendorff setup and intraoperative clinical data from

282 mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant m

283 In 2 models of ischemia/reperfusion using Langendorff-perfused guinea pig and mouse hearts, a sign

284 rve was assessed in RV- and left ventricular-Langendorff models and in vivo.

285 ed nanosystem was confirmed using an ex vivo Langendorff heart model.

286 nd stability in contraction arrested ex vivo Langendorff heart preparations before and during simulat

287 d in vivo by echocardiography and in ex vivo Langendorff perfused hearts.

288 nd 120 min of reperfusion, either as ex vivo Langendorff preparations or by in situ occlusion of the

289 tested in 125 optical movies from 5 ex vivo Langendorff-perfused PersAF sheep hearts (sensitivity/sp

290 e and human cardiomyocytes and in an ex vivo Langendorff-perfused whole-heart model.

291 Isolated hearts were Langendorff perfused and subjected to ischemia and reper

292 Nine pig hearts were Langendorff-perfused (atrial pacing, cycle length 650 ms

293 METHODS AND Isolated rat hearts were Langendorff-perfused and exposed to 40-minute normotherm

294 All hearts were Langendorff-perfused for optical mapping with voltage- a

295 Rat hearts were Langendorff-perfused, subjected to 35 minutes of regiona

296 -type (WT) and NOX-2 knockout (KO) mice were Langendorff perfused and subjected to 35 min ischemia/re

297 ene, hearts from 14 New Zealand rabbits were Langendorff-perfused.

298 earts from male (M) and female (F) rats were Langendorff-perfused for 30 min prior to either regional

299 Cardiac function was assessed with Langendorff perfusion and echocardiography.

300 Results obtained with Langendorff-perfused hearts showed that this difference