ライフサイエンスコーパス: Lys residue

1 terminal SDE2 fragment bearing an N-terminal Lys residue.

2 and general derivatizing agents for the 38C2 Lys residue.

3 rization switch moderated by a single buried Lys residue.

4 hich Glu at position 13 was substituted by a Lys residue.

5 sidue capable of interacting with a cationic Lys residue.

6 many instances, this motif is followed by a Lys residue.

7 endent ubiquitination on the pex12-1 ectopic Lys residue.

8 contain an average of nine Arg residues per Lys residue.

9 which recognizes LLO through its N-terminal Lys residue.

10 rnative mechanism, which depends on internal Lys residues.

11 he N-terminal domain of CtBP2 contains three Lys residues.

12 es isopeptide bond formation between Gln and Lys residues.

13 e beta-hairpin consisting of two Trp and two Lys residues.

14 ntification of factor XIIIa-reactive Gln and Lys residues.

15 to result from deprotonation of the flanking Lys residues.

16 nonalkaliphiles but contained fewer Arg and Lys residues.

17 n exhibits a high S1 specificity for Arg and Lys residues.

18 e by this enzyme can occur at a lone pair of Lys residues.

19 ased design of covalent inhibitors targeting Lys residues.

20 residue with minimal off-target labeling of Lys residues.

21 ne isopeptide bonds between specific Gln and Lys residues.

22 of modified peptides and assigning glycated Lys residues.

23 and O side chains of His, Cys, Glu, Asp, and Lys residues.

24 though salt bridge interactions with surface Lys residues.

25 anes of cells despite eight cationic Arg and Lys residues.

26 tra-GP(1) disulfide bonds, and four critical Lys residues.

27 um albumin (BSA) molecules by conjugation to Lys residues.

28 , which forms a Michael-type adduct with the Lys residues.

29 s both amine acceptor (Gln) and amine donor (Lys) residues.

30 a lesser extent, including ubiquitination at Lys residues 12, 21, and 23 and specific truncations at

31 Alanine substitutions of Lys residues 165 and 166 in human TF have been shown pre

32 greatest with peptides containing an Arg or Lys residue 5 positions downstream (P+5) from the Ser.

33 NH2-terminal region of the fragment and four Lys residues (539, 556, 580, 601) located in the COOH-te

34 was significantly reduced by substitution of Lys residues 642-645, indicating that these residues may

35 A Lys residue (679 in human POLN) of particular interest w

36 Replacement of the lactococcal DpsA Lys residues 9, 15 and 16 by Glu did not inhibit DNA bin

37 esidue in the second ATP-binding domain to a Lys residue, a mutation that is predicted to compromise

38 of HERG channels to neutral (Ala) or basic (Lys) residues accelerated the rate of channel deactivati

39 being buried in the protein interior, these Lys residues acquired pK(a) values comparable to those o

40 Ala residues were substituted for the Arg/Lys residues (ACSANA-HY1), and these substitutions did n

41 of the changes in cleavage of progastrin at Lys residues after omeprazole.

42 backbone by N(6) acylation of the central l-Lys residue and subsequent N(6)-hydroxylation of the cen

43 he CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this resid

44 s (IPBs)-formed between the amine group of a Lys residue and the carboxamide/carboxy group of Asn/Gln

45 ultiple amyloidogenic proteins by binding to Lys residues and disrupting hydrophobic and electrostati

46 es isopeptide bond formation between Gln and Lys residues and is allosterically regulated by GTP.

47 ed through isopeptide bonds between internal Lys residues and the C-terminus of Ub, can be assembled

48 The use of Arg, rather than Lys residues, and the inclusion of Tyr or Phe residues i

49 Our results show that these Lys residues are acetylated by the nuclear acetylase p30

50 queous phase only occurs at high pH when the Lys residues are de-protonated.

51 the IE promoter, indicating that the Gln and Lys residues are important for the DNA binding activity.

52 and Thr3 show reduced activity when adjacent Lys residues are modified.

53 m activation revealed that histone H3 and H4 Lys residues are not globally hyperacetylated during pha

54 Several surface-exposed Lys residues are present in IL-1beta, but not in IL1RN.

55 Ts) demonstrates that three highly conserved Lys residues are present in the catalytic domain of FucT

56 lysines from peptides containing up to three Lys residues are readily quantified using this method.

57 analysis was carried out to determine which Lys residues are sentrinized.

58 for 18C6, suggesting that the side chains of Lys residues are the preferred binding site for 18C6 com

59 Since lysine (Lys) residues are a major target for ubiquitination, we

60 its homologs autoadenylate on an active site Lys residue as part of a reaction intermediate that spec

61 One class utilizes an internal Lys residue as the active site nucleophile, and includes

62 caldarius adenylate kinase has the invariant Lys residue as well as the two Arg residues, its phospha

63 A Lys residue at P3' of Pro-sigma(K) could not be replaced

64 Substitution of a Lys residue at position 68 with Asn in MUG not only acce

65 NK1 killers depended on the presence of the Lys residue at position 80, an upward pointing residue n

66 Two Lys residues at amino acids 49 and 87 in the STAT3 NH2 t

67 ibution of positive charges by placing three Lys residues at both termini while maintaining identical

68 a subset that consists of Asp, Glu, His, and Lys residues at eight of the nine contiguous P6-P3' posi

69 Docking simulation predicted that three Lys residues at positions 180, 184, and 186 of the EGF-l

70 follow the N-end rule but depends on the two Lys residues at positions 4 and 17 of the native A1-chai

71 rometry of MDA-modified apoA-I revealed that Lys residues at specific sites had been modified.

72 d to be dependent on the number of L-lysine (Lys) residues at the C-terminus.

73 placement of Gln(881) with Asn, Glu, Asp, or Lys residues augmented the homolytic cleavage of 8R-HPOD

74 ith pKA values of about 5.9 and 8.4 (His and Lys residues?) but do not support a function for the pho

75 We mapped the acetylated Lys residues by tandem mass spectrometry and determined

76 chains (linked through different Ub lysine (Lys) residues) can confer different fates on target prot

77 ICA complexed with CH3NH3+ as a mimic of the Lys residue confirmed that such an interaction lowered t

78 contains the sequence Lys-Pro-Glu where the Lys residue contacts the gamma-phosphate of ATP and the

79 s also consistent with the pKa values of the Lys residues determined previously.

80 The position-a Lys residues do not, however, confer a single preference

81 Here we show that modulating the number of Lys residues does not affect recognition events within t

82 i) on-resin incorporation of the linker at a Lys residue epsilon-amine, (ii) Fmoc-SPPS elongation of

83 sing on the Ub molecule that contributes the Lys residue for chain formation, we found that specific

84 WP2 is a HECT E3 ligase that targets protein Lys residues for ubiquitination and is comprised of an N

85 possessing a diketone linker reacts with the Lys residues forming an enaminone derivative.

86 other PLP-dependent enzymes, an active site Lys residue forms a Schiff base with PLP in the absence

87 The conserved Lys residue found adjacent to the axial ligand in the se

88 in must proceed in a way that protects these Lys residues from attack by E3 ligases.

89 omponent of lipoprotein(a) and COOH-terminal Lys residues generated by partial degradation of fibrin

90 Nineteen of the Lys residues have depressed pK(a) values, some as low as

91 ch as histone acetylation and methylation on Lys residues-have been linked to these lasting actions o

92 tion of pro-KLK6 requires hydrolysis after a Lys residue; however, KLK6 exhibits 2 order of magnitude

93 This crystal structure reveals a Lys residue hydrogen-bonded to PQQ at the site analogous

94 urements on OspA specifically 15N-labeled at Lys residues identified the locations of the two folding

95 hat several conserved motifs consisting of a Lys residue immediately followed by a Ser residue are pr

96 e of L-lysine complexed with E. coli LysRS2 (lysS), residues implicated in amino acid recognition and

97 an abnormally lower pKa compared with other Lys residues, implying that the catalytic Lys may act as

98 A juxtamembrane Lys residue in beta also has an important role in the in

99 e of R3.29 in TM3 seems to be fulfilled by a Lys residue in EL2, whereas the R7.39 in TM7 seems to be

100 her the probes were covalently attached to a Lys residue in Gag or to residues specifically within th

101 emical data, the unusual conformation of the Lys residue in S.acidocaldarius adenylate kinase is expl

102 The Lys residue in the conserved DEK motif coordinates the n

103 o investigate the function of this conserved Lys residue in the large and small subunits of the heter

104 due in forming a polar bridge to a conserved Lys residue in the receptor to mediate changes in signal

105 ptor fold and a highly conserved active-site Lys residue in the seventh transmembrane segment of the

106 ydrophobic patch is interrupted by a charged Lys residue in the T1-SP10RF(A) peptide.

107 Acetylation of the Lys residue in this motif, demonstrated in vivo by using

108 ate NMR demonstrated binding of CLR01 to the Lys residues in Abeta at the earliest stages of assembly

109 The microenvironments (pKa) of Lys residues in apo B-100 in small, dense, intermediate,

110 sults with the mutants indicate that several Lys residues in b(5) are sensitive to the interaction wi

111 e NCX1-CBD1 structure are neutralized by two Lys residues in CALX1.1-CBD2.

112 are critical for the usage of the respective Lys residues in chain synthesis.

113 Mutations of Walker A Ser and Lys residues in combination with E552A/E1197A had the sa

114 Furthermore, three Lys residues in DbpA appear to be critical for the bindi

115 tion was also prevented by altering the four Lys residues in its cytosolic domain to Arg, suggesting

116 pid proteasome-mediated degradation required Lys residues in MHCI heavy chain ectodomain.

117 L-lysine (Bz-Gly-Lys) as a model compound of Lys residues in protein and 13-hydroperoxyoctadecadienoi

118 that eHAV release is strongly dependent upon Lys residues in pX.

119 the emerging role of acetylation of critical Lys residues in regulating APE1 functions.

120 , and selectively react through the reactive Lys residues in the Ab binding sites to form 38C2 conjug

121 Human hemoglobin contains 11 Lys residues in the alpha chain and 10 Lys residues in t

122 ns 11 Lys residues in the alpha chain and 10 Lys residues in the beta chain.

123 Lys residues in the C terminus of apoA-I were targeted f

124 conjugation sites in the cytoplasmic tail or Lys residues in the ectodomain.

125 Finally, participation of C-terminal Lys residues in the full-length alpha-syn fibril assembl

126 oying IgG4, in line with the lower number of Lys residues in the hinge region of the latter.

127 SRCR domains 2 and 3 with the two basic Arg/Lys residues in the Hp loop.

128 ng selected Ca(2+)-ligands or by introducing Lys residues in the membrane-binding loops had variable,

129 pH could not be resolved from those of other Lys residues in the molecule.

130 Two conserved Lys residues in the N-terminal domain of human immunodef

131 ide substrates with a preference for Arg and Lys residues in the P-1 position.

132 nd K483, and at least two other unidentified Lys residues in the surface loops of the outer membrane

133 n of the relative reactivities of respective Lys residues in the ubiquitin.

134 tionicity, manifested by abundant Arg and/or Lys residues in their sequences.

135 minal sequencing demonstrated that, of the 7 Lys residues in ubiquitin, Lys(6) was the most readily l

136 chiff-base and Michael-addition adducts with Lys residues, in addition to causing oxidation of Met re

137 gen-bonded network that positions the acidic Lys residue; in the active site of KGPDC, the homologous

138 )F TOCSY peaks were observed between two TFA-Lys residues incorporated into the proteins AncCDT-1 and

139 gy modeling and suggested that a pro-peptide Lys residue intrudes into the S2 pocket, which is more s

140 ars lining the walls of the groove while the Lys residue is able to form a salt bridge with a proxima

141 This Lys residue is adjacent to the consensus CtBP binding mo

142 ently edits Cys-tRNAPro and that a conserved Lys residue is essential for this activity.

143 Protein acetylation on Lys residues is recognized as a significant post-transla

144 the ability of SacAcuA to acetylate multiple Lys residues is unique among AcuA-type acetyltransferase

145 we demonstrate that mutations at a different Lys residue, K294, may modulate the fidelity of Tth DNA

146 3A-APC (Lys191-193Ala) mutant in which three Lys residues (KKK191-193) were replaced with alanine, an

147 th an intramolecular crosslink to a proximal Lys residue, leading to increased thermal stability.

148 nge columbic interactions between basic (Arg/Lys) residues located N-terminally to the phosphorylated

149 os coiled coil contains two polar position a Lys residues (Lys 16 and Lys 30 of Fos-p1, a peptide cor

150 Mutation of any one of the HAH1p C-terminal Lys residues (Lys(56), Lys(57), or Lys(60)) to Gly does

151 CYP27A1 exhibited only three Lys residues, Lys(134), Lys(358), and Lys(476), that rea

152 binds to a pocket formed by three conserved Lys residues (Lys314, Lys326, and Lys328) on the surface

153 SUMOylation occurred at a single Lys residue, Lys428, of CtBP1.

154 mprised of 11 amino acids and flanked by two Lys residues, Lys573 and Lys583, that are located at the

155 e active site of KGPDC contains a homologous Lys residue (Lys64).

156 nding of E128K IL-1beta, suggesting that the Lys residues mediate integrin binding.

157 APE1 ubiquitination occurred specifically at Lys residues near the N-terminus, and was markedly enhan

158 ed upon iminium formation with a neighboring Lys residue of model small peptides.

159 itute Ala and Gln residues for the conserved Lys residue of the Walker A box for nucleotide binding.

160 crosslinks could be formed between FPheK and Lys residue of two interacting proteins, including the h

161 L31C-PLB failed to cross-link to any Cys or Lys residue of wild-type SERCA2a, L31C did cross-link wi

162 We show that although the C'-terminal Lys residue of Wnt3a is critical for its activity and is

163 he existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, wh

164 talyze the hydroxylation of all telopeptidyl Lys residues of collagen?

165 Although all three Lys residues of CtBP2 (Lys-6, Lys-8, and Lys-10) appear

166 The N-terminal Lys residues of Escherichia coli Dps have been implicate

167 Alanine scanning mutagenesis of 12 Arg/Lys residues of exosite 2 revealed a defect in 9a potenc

168 hrough ionic interactions formed between the Lys residues of FPR and Asp/Glu residues of FdI.

169 ribed genes are typically hyperacetylated at Lys residues of histones H3 and H4 and hypermethylated a

170 lpha/epsilon-amino group of one of the seven Lys residues of lycosin-I, generating eight different li

171 flanking the active site, comprising several Lys residues of nsp14 and the N-terminal amino group of

172 void of SacAcuA, none of the above-mentioned Lys residues of SacAcsA was acetylated.

173 geted agent by conjugating folic acid to the Lys residues of the apolipoprotein B (apoB)-100 protein.

174 ing site on ROMK1, all intracellular lysine (Lys) residues of ROMK1 were individually mutated to argi

175 When lysine (Lys) residues of the hD4R are substituted with arginine

176 lation and activation, and ubiquitylation of Lys residues on a cohort of MOM proteins, occur similarl

177 ow that (i) the effects of buried position a Lys residues on coiled-coil oligomerization are context

178 Mutation of the two Lys residues on the binding face of the beta-hairpin res

179 The SUMOylation sites included three Lys residues on the bipartite nuclear localization seque

180 umber of targets, including six of the seven Lys residues on Ub itself with a Lys-48>Lys-63>Lys-11>>>

181 n-like modifier (SUMO) proteins to a lysine (Lys) residue on target proteins, enhances EZH2 transcrip

182 that catalyzes the hydroxylation of lysine (Lys) residues on collagen, and this particular isozyme h

183 peat (of seven) either with a bulky, charged Lys residue or with a Ser residue (sometimes found in th

184 nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the NLS, and the

185 etween the suramin sulfonated groups and Arg/Lys residues play critical roles in the binding of suram

186 Mutation of the central Lys residue PLD(K564A) of this motif abolished the PLDal

187 ificity appears to be determined by a single Lys residue present in a sequence motif conserved in all

188 While the substitution of the two Lys residues present in ricin A chain with arginine slow

189 tion is required for enzyme activity, with a Lys residue providing higher intrinsic activity.

190 Inclusion of exon 16 introduces a pair of Lys residues, providing a site for controlled endoproteo

191 We also found that a conserved Lys residue required for PP5 binding to hsp90 was critic

192 ngly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-accessible surfac

193 valent neutralization of the unpaired Asp or Lys residue, respectively, with n-alkylsulfonates or n-a

194 roduction in position 204(C+6) of a Glu or a Lys residue, respectively.

195 events, initiated by acetylation of a single Lys residue, results in proteolysis of RNase R in expone

196 hesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by

197 ement by covalently tethering rhodopsins via Lys residue side chains.

198 th nucleophosmin and rRNA through N-terminal Lys residues, some of which (K(27)/K(31)/K(32)/K(35)) ma

199 A binding were abrogated by mutation of both Lys residues, suggesting that either one can bind ATP.

200 was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.

201 eling and identification of reactive Gln and Lys residues targeted by factor XIIIa in rFnbA.

202 A Lys residue that is critical for this step is located in

203 ectly juxtapose an aryl-fluorosulfate with a Lys residue that is located within the binding pocket of

204 lar interactions involving buried position-a Lys residues that can interact favorably only with surfa

205 he cytoplasmic tail of IFNAR1 contains seven Lys residues that could function as potential ubiquitin

206 ng-mass spectrometry approach identified two Lys residues that formed an inter-protein crosslink acro

207 s, nor does it associate with methylated Arg/Lys residues through its aromatic cage.

208 ns, little is known about how E3s select the Lys residue to be used in chain synthesis.

209 Mutation of the Lys residue to Gln resulted in a decrease in CtBP bindin

210 Systematic mutation of these Lys residues to Arg shows that only carbamylation of Lys

211 Mutating all three Lys residues to Glu (the 3KE mutation) did not affect th

212 Substitution of the Lys residues to Glu markedly reduced integrin binding of

213 occur within the subunits, exposing Arg and Lys residues to negatively charged binding sites of P-tR

214 Mutation of these Lys residues to neutral residues decreased PAK binding t

215 ets for ubiquitination since mutation of all Lys residues, to which the ubiquitin moiety is conjugate

216 lly coupled to surface exposed Cyt c lysine (Lys) residues using succinimidyl chemistry via amide bon

217 quence was either scrambled or if a critical Lys residue was chemically modified.

218 quasi-DET, engineered AvLOx with additional Lys residue was designed.

219 The additional Lys residue was introduced by substituting residue locat

220 Lys-gingipain to cleave human hemoglobin at Lys residues was confirmed by electrospray ionization Fo

221 or its cytoplasmically exposed Ser, Thr, and Lys residues was still down-regulated, ubiquitinated, an

222 oint mutants, each lacking a single Walker A Lys residue, was generated to study the effects of aboli

223 The pK(a) values of some of the internal Lys residues were affected by interactions with surface

224 eversing mutant of the pro peptide where Arg/Lys residues were changed to Asp, and Asp/Glu residues t

225 sitions 1 and/or 23 in the primary sequence, Lys residues were introduced to ensure water solubility.

226 Several acetylated Lys residues were mapped by tandem mass spectrometry, an

227 id (PNA) anti-miRs containing a few attached Lys residues were potent miRNA inhibitors.

228 Cyt c2 molecules in which positively charged Lys residues were replaced with Glu.

229 (hBD1) and (Lys-->Arg)hBD1 in which all four Lys residues were substituted for Arg.

230 uto-ubiquitination site of TRAF6 to a single Lys residue, which if mutated renders TRAF6 unable to ac

231 20 amino acids each that is rich in Gln and Lys residues, which are potential transglutaminase subst

232 lectropositive surface with six Arg and five Lys residues, which presumably interacts with the negati

233 vity toward DNA with an increasing number of Lys residues, while a corresponding decrease in complex

234 Chymotrypsin prefers P1' Arg/Lys residues, while trypsin prefers hydrophobic P1' resi

235 ution of the Ca(2+)-coordinating Asp310 by a Lys residue, whose side-chain amine may have functionall

236 Replacement of a conserved Lys residue with Ala abolished the in vitro RNA-binding

237 y that the replacement of a partially buried Lys residue with Glu at position 49 in E.coli HPr increa

238 ted agents that targeted a relatively remote Lys residue with respect to the target's binding site, t

239 unit was altered by replacing the C-terminal Lys residue with three Asp residues.

240 edundant nature of interaction of P1 Arg and Lys residues with Asp129, Tyr150 and Ser163 of the enzym

241 ith respect to their lack of the "invariant" Lys residue within the phosphate-binding loop, and two A

242 Here, we show that a Lys residue within the pilin-like motif of the EbpC subu

243 pping and tandem mass spectrometry that five Lys residues within the cytoplasmic loop, including Lys1

244 position favorable to form salt bridges with Lys residues within the EH-domain.

245 nteractions and acetylation of some internal Lys residues within the N-terminal segments of the histo

246 te and its polyubiquitylation at an internal Lys residue without substrate's dissociation into the bu