ライフサイエンスコーパス: MAIT cell

1 nds to mucosal-associated invariant T cells (MAIT cells).

2 (lL)-12 + IL-18 as compared with circulating MAIT cells.

3 ly MR1A can present mycobacterial antigen to MAIT cells.

4 the first transcriptomic analysis of murine MAIT cells.

5 more accurately in CD8(+) than CD4(-)CD8(-) MAIT cells.

6 ng indispensable for TNF-alpha production by MAIT cells.

7 cytokine expression (IFNgamma, TNF) by human MAIT cells.

8 ompounds, that either inhibited or activated MAIT cells.

9 eactivity in a discrete subset of TRAV1-2(+) MAIT cells.

10 exacerbations and is a plausible target for MAIT cells.

11 ts that control the generation of functional MAIT cells.

12 on of MR1 Ags as well as into the biology of MAIT cells.

13 geneous and largely distinct from TRAV1-2(+) MAIT cells.

14 nds from Mycobacterium tuberculosis (Mtb) to MAIT cells.

15 phoidal Salmonella enterica strains activate MAIT cells.

16 entation of exogenous metabolite antigens to MAIT cells.

17 ted liver cirrhosis, and focus especially on MAIT cells.

18 d the capacity of monocytic APC to stimulate MAIT cells.

19 T) cells and mucosal-associated invariant T (MAIT) cells.

20 to activate mucosal-associated invariant T (MAIT) cells.

21 tabolites to Mucosal-Associated Invariant T (MAIT) cells.

22 In the rabbit, which has very few NKT and no MAIT cells, a previously unrecognized iTRA was identifie

23 nalyses of fibrotic kidney tissue identified MAIT cells accumulating adjacent to PTECs.

24 These antigens also induce MAIT cell accumulation in mouse lungs after administrati

25 MAIT cells act in adipose tissue by inducing M1 macropha

26 Notably, MAIT cells activated in the presence of human PTECs unde

27 apy rapidly decreased liver inflammation and MAIT cell activation and cytotoxicity, and increased the

28 Our data suggest the following: 1) MAIT cell activation and exhaustion is uncoupled from th

29 asal MAIT cell priming in mice induces early MAIT cell activation and expansion after M. tuberculosis

30 ugh MAIT cell priming significantly enhanced MAIT cell activation and expansion early after M. tuberc

31 coccus pneumoniae vaccine were assessed in a MAIT cell activation assay.

32 Coexpression of MR1B with MR1A decreases MAIT cell activation following bacterial infection.

33 ment with interferon-alpha leads to specific MAIT cell activation in vivo in parallel with an enhance

34 MAIT cell activation is biphasic with a rapid TCR Vbeta2

35 Antigen solution structures, MAIT cell activation potencies (EC50 3-500 pM), and chem

36 ribityl chain of the AML strongly influences MAIT cell activation potency through dynamic compensator

37 tigen 5-OP-RU affect presentation by MR1 and MAIT cell activation remains unclear.

38 l stereochemical and energetic influences on MAIT cell activation, enabling design of a water stable

39 ide new insights into antigen properties and MAIT cell activation.

40 R1 pool and hampers antigen presentation and MAIT cell activation.

41 P, for MR1 binding and inhibit MR1-dependent MAIT cell activation.

42 otein 1 (MR1) participation, is required for MAIT cell activation; iv) MAIT cell responses to SEB can

43 MAIT cells activation was observed during infection with

44 ses of blood mucosal associated invariant T (MAIT) cells against in vitro stimulation with pneumococc

45 The frequency of MAIT cells among T cells was significantly lower in bloo

46 bundant in the tissues, our study focuses on MAIT cell analyses in blood.

47 cilitates evasion from immune recognition by MAIT cells and contributes to the invasive pathogenesis

48 sms dictating the interactions between human MAIT cells and DCs and demonstrate that human MAIT cells

49 We cocultured MAIT cells and human primary proximal tubular epithelial

50 lecule CD1d, suggestive of a niche shared by MAIT cells and natural killer T cells (NKT cells).

51 pathways to mucosal-associated invariant T (MAIT) cells and other MR1-restricted T cells.

52 iNKT) cells, mucosal-associated invariant T (MAIT) cells, and gammadelta T cells, maintain a poised e

53 cognize AMLs, thereby providing insight into MAIT cell antigen specificity and potency.

54 Thus, MAIT cell antigen-mediated immunotherapy for M. tb.

55 nasal installation of a TLR2/6 agonist and a MAIT cell antigen.

56 ouse macrophages are relatively resistant to MAIT cell antimicrobial activities in vitro.

57 In adults, cutaneous MAIT cells are a dominant population of interleukin-17A

58 MAIT cells are activated and expand in blood and mucosa

59 and velpatasvir, we found that intrahepatic MAIT cells are activated by monocyte-derived cytokines a

60 The MAIT cells are activated by mycobacteria, and prior huma

61 Together these data demonstrate MAIT cells are activated following viral infections, and

62 Here, we demonstrate that MAIT cells are also activated during human viral infecti

63 with age in humans, our understanding of how MAIT cells are altered during different phases across th

64 tibility complex (MHC)-related 1-restrictied MAIT cells are detected at similar levels with tetramers

65 Our data suggest that MAIT cells are highly activated and become dysfunctional

66 for the first time that: i) mouse and human MAIT cells are hyperresponsive to SAgs, typified by stap

67 Our data demonstrate that MAIT cells are major contributors to the early cytokine

68 Thus, MAIT cells are of interest in HIV/SIV vaccination and in

69 MHC-restricted T cells, blood frequencies of MAIT cells are poor correlates of TB disease but may pla

70 argely contributed by IL-12 and IL-18; v) as MAIT cells are primed by SAgs, they also begin to develo

71 avin metabolite antigens have suggested that MAIT cells are relatively homogeneous and uniform in res

72 We show that MAIT cells are strongly activated and represent the majo

73 in this study reveal for the first time that MAIT cells are systemically depleted in an AIDS virus in

74 Mucosa-associated invariant T (MAIT) cells are a large innate-like T-cell subset in hum

75 Mucosal-associated invariant T (MAIT) cells are a population of innate T cells, which we

76 Mucosal-associated invariant T (MAIT) cells are a recently described abundant, proinflam

77 Mucosal-associated invariant T (MAIT) cells are a recently discovered, innate-like subse

78 Mucosa-associated invariant T (MAIT) cells are a unique innate T cell subset that is ne

79 Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacteri

80 human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells that recognize antigens

81 Mucosal-associated invariant T (MAIT) cells are abundant T cells with unique specificity

82 Mucosal-associated invariant T (MAIT) cells are activated by microbial riboflavin-based

83 Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by

84 Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset important i

85 Mucosa-associated invariant T (MAIT) cells are an innate-like T cell subset in mammals

86 Mucosal-associated invariant T (MAIT) cells are enriched in the liver as compared with t

87 Mucosal-associated invariant T (MAIT) cells are important for immune responses against m

88 Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermedia

89 Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacter

90 Mucosa-associated invariant T (MAIT) cells are innate-like antimicrobial T cells recogn

91 Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in mucosal

92 Mucosal-associated invariant T (MAIT) cells are MHC-related protein 1 (MR1)-restricted T

93 Mucosal-associated invariant T (MAIT) cells are nonconventional T lymphocytes that recog

94 Mucosal-associated invariant T (MAIT) cells are semi-invariant T cells specifically reco

95 Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens pre

96 Mucosal-associated invariant T cells (MAIT cells) are innate-like T-cells that recognize deriv

97 er T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population

98 in the absence of TCR ligation, identifying MAIT cells as innate sentinels in inflammatory environme

99 cells, called mucosa-associated invariant T (MAIT) cells, as the most powerful source of pro-inflamma

100 minantly upregulated on the surface of human MAIT cells by innate cytokine stimulation.

101 y, the data suggest that activation of blood MAIT cells by innate inflammatory cytokines is a major m

102 Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad

103 We identified MAIT cells (CD3(+) TCR Valpha7.2(+) CD161(hi)) in health

104 We confirmed that MAIT cell clones were unable to respond to MR1(-/-) clon

105 brosis had significantly elevated numbers of MAIT cells compared with either nonfibrotic samples from

106 Escherichia coli-specific responses in aged MAIT cells compared with their young adult counterparts

107 receptor alpha (TCRalpha) repertoire in the MAIT cell compartment without redistribution to other an

108 Mucosa-associated invariant T (MAIT) cells contribute to host immune protection against

109 This suggests that peritoneal MAIT cells could be of interest for immune-intervention

110 the intrinsic metabolic pathways controlling MAIT cell cytokine production and highlight mTORC1 as an

111 he mechanisms behind conventional T-cell and MAIT cell cytotoxic responses to NTHi.

112 We show that MAIT cell cytotoxic responses were upregulated by a comb

113 Adoptive transfer of Mo-DCs to MAIT cell-deficient mice (MR1(-/-) mice) rescued their d

114 In both cohorts, frequencies of MAIT cells defined by MR1-tetramer staining and coexpres

115 n studies indicate that blood frequencies of MAIT cells, defined by cell surface markers, decline dur

116 We further demonstrate that MAIT cell-dependent GM-CSF production stimulated monocyt

117 anding of HIV/SIV pathogenesis and implicate MAIT cell depletion in the disease process.

118 Furthermore, we show that MAIT cell-derived signals synergize with microbial stimu

119 Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives pres

120 s on a specific temporal window, after which MAIT cell development is permanently impaired.

121 early after M. tuberculosis challenge, these MAIT cells did not restrict M. tuberculosis bacterial lo

122 In this review we discuss how MAIT cells display antimicrobial, homeostatic, and ampli

123 Peritoneal MAIT cells displayed an activated tissue-resident phenot

124 Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV

125 We investigated MAIT cells during clinical and experimental sepsis, and

126 is uncoupled from the hallmark depletion of MAIT cells during HIV infection; and 2) the lack of PTM

127 and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repert

128 pathogenic, rather than protective, role for MAIT cells during infection.

129 We investigated MAIT cell dynamics and function in rhesus macaque blood

130 rize the key molecular mechanisms that drive MAIT cell effector functions and to identify those which

131 ring, thereby equally augmenting Ag-specific MAIT cell effector functions.

132 MAIT cell effector responses against E. coli and C. albi

133 during HIV infection; and 2) the lack of PTM MAIT cell enrichment at the gut mucosa may prevent deple

134 ting M. tuberculosis growth, suggesting that MAIT cell enrichment in the lung is not sufficient to co

135 Some of these ligands inhibited MAIT cells ex vivo and in vivo, while others, including

136 We find that MAIT cells fail to substantially accumulate in the lungs

137 an macaques, several studies have shown that MAIT cell frequencies actually decrease in peripheral bl

138 MAIT cell frequencies in blood and BAL correlated with S

139 criptional signatures did not correlate with MAIT cell frequencies in patients with TB.

140 During SBP, peritoneal MAIT cell frequencies increased most among all major imm

141 tivation and cytotoxicity, and increased the MAIT cell frequency among intra-hepatic but not blood T

142 Overall, SIV vaccination influenced MAIT cell frequency and functionality.

143 ating alpha4beta7, coinciding with increased MAIT cell frequency in the rectum.

144 Measurements included MAIT cell frequency, phenotype, and cytokine-producing c

145 r levels of activation and cytotoxicity than MAIT cells from blood (P < .0001).

146 activation, were significantly increased on MAIT cells from fibrotic tissue samples.

147 Removal of MAIT cells from older individuals and an aged environmen

148 Depletion of MAIT cells from PBMC resulted in decreased total product

149 MAIT cells from the liver had higher levels of activatio

150 ne effector molecule profile comparable with MAIT cells from younger adults.

151 t drugs and drug-like molecules can modulate MAIT cell function in mammals.

152 indings establish a novel mechanism by which MAIT cells function to promote both innate and adaptive

153 cumulating evidence, however, indicates that MAIT cell functions are inducible by cytokine stimuli in

154 Although PTM MAIT cells generally resemble the phenotype and transcri

155 Thus, the conserved and innate-like MAIT cells harbor multiple layers of functional heteroge

156 The iNKT and MAIT cells have a highly similar transcriptional pattern

157 that is important in antimicrobial defense, MAIT cells have immune-modulatory functions that could e

158 ditions associated with selective absence of MAIT cells have not been identified.

159 Mucosal-associated invariant T (MAIT) cells have been attracting increasing attention ov

160 Mucosal-associated invariant T (MAIT) cells help combat opportunistic infections.

161 ion profiles and clonal expansion in iNKT or MAIT cells, highly expanded conventional CD8(+) T cells

162 bsiella pneumoniae and Escherichia coli; vi) MAIT cell hyperactivation and anergy co-utilize a signal

163 -dependent manner, and this is essential for MAIT cell IFN-gamma production.

164 een iNKT and mucosal-associated invariant T (MAIT) cells, illustrating a common core developmental pr

165 NTHi constitutes a target for pulmonary MAIT-cell immune responses, which are significantly impa

166 Finally, although the MAIT cell immunoproteome was overall relatively homogeno

167 es of a T cell antigen receptor (TCR) from a MAIT cell in complex with MR1 bound to the non-stimulato

168 ls of infection have demonstrated a role for MAIT cells in antimicrobial defense.

169 performed flow cytometry on CD3+Va7.2+CD161+ MAIT cells in blood of 55 cHBV patients.

170 ls, but they had higher percentages of CD38+ MAIT cells in blood, which declined on entecavir treatme

171 n of tissue-resident markers (CD103/CD69) on MAIT cells in both states.

172 Little is known, however, about MAIT cells in diseases of the kidney, including CKD.

173 ation and the loss/dysfunction of peripheral MAIT cells in HIV infection is well described, MAIT cell

174 on, which is a critical effector function of MAIT cells in host defense.

175 However, proposed protective roles of MAIT cells in human infections remain unproven and clini

176 To evaluate MAIT cells in human native kidneys with tubulointerstiti

177 f human MR1, forms MR1 tetramers that detect MAIT cells in human PBMCs, and stimulates cytokine expre

178 ervations may aid in deciphering the role of MAIT cells in immune responses to HBV.

179 Little is known about the role of MAIT cells in livers of patients with chronic hepatitis

180 Here we investigate the role of MAIT cells in M. tb.

181 IT cells in HIV infection is well described, MAIT cells in nonhuman primate models are poorly charact

182 These data suggest that MAIT cells in older individuals, although associated wit

183 Peripheral blood MAIT cells in patients with STSS expressed elevated leve

184 PTM)-specific MR1 tetramer and characterized MAIT cells in serial samples from naive and SIV- or simi

185 e novo riboflavin synthesis, and the role of MAIT cells in STSS has therefore so far been overlooked.

186 of chronic inflammation, the contribution of MAIT cells in such scenarios needs to be determined.

187 findings indicate that human tissue-resident MAIT cells in the kidney may contribute to the fibrotic

188 inverse correlation between the frequency of MAIT cells in the liver and histologically determined le

189 ata provide evidence for a cytotoxic role of MAIT cells in the lung and highlight important differenc

190 nd, 5-OP-RU, resulted in robust expansion of MAIT cells in the lung.

191 t for early recognition of infected cells by MAIT cells in the lung.

192 Together our data highlight the role of MAIT cells in the maintenance of gut integrity and the c

193 These results implicate MAIT cells in the protection against pneumococcal coloni

194 ation of the gut microbiota, we investigated MAIT cells in this pathology.

195 the human life span, we show that naive-like MAIT cells in umbilical cord blood switch to a central/e

196 stingly, BCG-induced IFN-gamma expression by MAIT cells in vitro was mediated by the innate cytokines

197 Activation of human MAIT cells in whole blood leads to MR1- and cytokine-dep

198 tic (NOD) strain, we detected alterations in MAIT cells, including increased production of granzyme B

199 Both MAIT cell-induced tissue alterations contribute to metab

200 Treatment with MAIT cell inhibitory ligand demonstrates its potential a

201 cteristic of mucosal-associated invariant T (MAIT) cells is the expression of TRAV1-2(+) T cell recep

202 s and human immunodeficiency virus patients, MAIT cells isolated from HBV patients are not deleted bu

203 of in vitro experiments, we demonstrate that MAIT cells isolated from obese adults display defective

204 Vaccination increased MAIT cell levels in blood and BAL expressing the antivir

205 a show systemically decreased frequencies of MAIT cells likely attributable to enhanced turnover in S

206 developmental stages and checkpoints for the MAIT cell lineage in humans and mice.

207 we identify a new inflammatory mechanism in MAIT cells linking the DR3/TL1A axis with amplification

208 Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a signific

209 AIT cells and DCs and demonstrate that human MAIT cells mature monocyte-derived and primary DCs in an

210 Emerging data suggest that MAIT cells may be an attractive target for vaccine-induc

211 MAIT cells may therefore provide an attractive therapeut

212 cells and CD8 cells, but most potently from MAIT cells (median IFN-gamma-positive frequencies, 2.9,

213 study we investigated the interplay between MAIT cell-mediated antibacterial effector functions and

214 Monitoring of MAIT cells might represent a new biomarker of T1D, while

215 Mucosal-associated invariant T (MAIT) cells might play a role in control of viral replic

216 Despite severely diminished MAIT cell numbers and impaired phenotype in circulation,

217 the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predict

218 MAIT cells of patients at sepsis presentation were signi

219 Peripheral MAIT cells of patients in the HBeAg-negative phase were

220 MAIT cells of WT mice expressed lower levels of IFN-gamm

221 d to reveal an effect of P2C/5-OP-RU-induced MAIT cells on M. tuberculosis control.

222 BAL MAIT cells only increased after the first Ad immunizatio

223 Increased frequencies of blood MAIT cells over the course of vaccination were observed,

224 MAIT cell phenotype and function were analyzed using hig

225 y, distribution, and clonotypic structure of MAIT cell populations in the peripheral blood, liver, me

226 Furthermore, stage 3 MAIT cell populations were expanded in mice deficient in

227 Spn colonization and with increased mucosal MAIT cell populations.

228 a and granzyme B in lung CD4(+), CD8(+), and MAIT cell populations.

229 Stage 1 and stage 2 MAIT cells predominated in thymus, while stage 3 cells p

230 However, MAIT cell presence and function in the peritoneal cavity

231 We conclude that intranasal MAIT cell priming in mice induces early MAIT cell activa

232 n priming and aerosol infection, and testing MAIT cell priming in nitric oxide synthase 2 (NOS2)-defi

233 Although MAIT cell priming significantly enhanced MAIT cell activ

234 In this study, we tested whether a MAIT cell priming strategy could protect against aerosol

235 Although artificially induced MAIT cells produce important cytokines in both infection

236 We provide evidence to show that MAIT cells promote early differentiation of CCR2-depende

237 Here we show that during obesity MAIT cells promote inflammation in both adipose tissue a

238 Consequently, local activation of cutaneous MAIT cells promotes wound healing.

239 typhoidal invasive disease in Africa, escape MAIT cell recognition through overexpression of ribB Thi

240 MAIT cells recognize bacterial small molecule metabolite

241 MAIT cells recognize microbial riboflavin metabolites of

242 Mucosal-associated invariant T (MAIT) cells recognize microbial non-peptidic antigens pr

243 Mucosal-associated invariant T (MAIT) cells recognize MR1-presented antigens derived fro

244 yme B(+) and gamma interferon (IFN-gamma)(+) MAIT cells relative to that in uninfected P2C/5-OP-RU-tr

245 velopment of mucosal-associated invariant T (MAIT) cells relies on a specific temporal window, after

246 mpaired phenotype in circulation, peritoneal MAIT cells remain abundant, activated, and highly functi

247 Mucosal-associated invariant T (MAIT) cells represent a specialized lymphocyte populatio

248 We report that MAIT cells repress group 2 innate lymphoid cell activati

249 PTM MAIT cells responded to SIV/simian HIV infection by prol

250 These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show ho

251 ylococcal enterotoxin B (SEB); ii) the human MAIT cell response to SEB is rapid and far greater in ma

252 The MAIT cell response to T-cell receptor-mediated stimulati

253 Here, we found that MAIT cell responses against Escherichia coli and Candida

254 vaccination activated mycobacteria-specific MAIT cell responses in humans.

255 ly higher polyfunctionality and magnitude of MAIT cell responses involving a range of effector functi

256 conducted a comprehensive analysis of human MAIT cell responses to GAS, aiming to understand the con

257 n, is required for MAIT cell activation; iv) MAIT cell responses to SEB can occur in a T cell recepto

258 The boost of MAIT cell responses was dependent on strongly enhanced M

259 t is impaired in obesity, leading to altered MAIT cell responses.

260 cine-induced Abs enhanced Ag presentation to MAIT cells, resulting in more potent effector responses.

261 Paired TCRalphabeta analyses of MAIT cells revealed large clonal expansions in older adu

262 were deficient in MR1, and therefore lacked MAIT cells, revealed a loss of gut integrity and increas

263 -specific alpha-CD3, alpha-CD28 stimulation, MAIT cells showed a greater capacity to secrete cytokine

264 In this study, we found that MAIT cells significantly upregulate their rates of glyco

265 The MAIT cell-specific phenotype did not extend to other inn

266 Culture of MAIT cell supernatants with B cells led to greater tissu

267 infection and the potential for MAIT cell-targeted immunotherapy to control bacterial bu

268 s, and mucosal-associated invariant T cells (MAIT cells) that are restricted to the MHC-related prote

269 enotype and transcriptional profile of human MAIT cells, they exhibited uniquely low expression of th

270 In contrast to TRAV1-2(+) MAIT cells, this TRAV12-2-expressing clone displays a di

271 antigens) to mucosal-associated invariant T (MAIT) cells through an uncharacterized pathway.

272 We found circulating MAIT cells to be severely decreased in patients with cir

273 The ability of MAIT cells to exhibit microbe-specific functional specia

274 ation by IgG opsonization allows innate-like MAIT cells to mount a faster, stronger, and qualitativel

275 The potential for MAIT cells to provide help to B cells was evident during

276 AS, aiming to understand the contribution of MAIT cells to the pathogenesis of STSS.

277 cell subsets, suggestive of active homing of MAIT cells to the site of infection.

278 ntial immunotherapeutic approaches to modify MAIT cell trafficking during HIV infection.

279 Notably, development of MAIT cells was also impaired in the absence of Bcl6.

280 checkpoint that generated mature functional MAIT cells was controlled by multiple factors, including

281 Production of interferon gamma by MAIT cells was dependent on monocyte-derived interleukin

282 By 36 wk of infection, PTM MAIT cells were activated and exhibited a loss of Tbet e

283 We tested whether frequencies of blood MAIT cells were altered in patients with TB disease rela

284 Cytokine-producing MAIT cells were as frequent, but granzyme B-producing MA

285 MAIT cells were depleted by the onset of the adaptive im

286 s were as frequent, but granzyme B-producing MAIT cells were more frequent upon stimulation with Esch

287 The MAIT cells were not deleted in blood or liver of cHBV pa

288 Low frequencies of MAIT cells were observed in the peripheral blood, MLNs,

289 MAIT cells were reduced in bronchial biopsies from subje

290 In contrast, in ascites fluid, MAIT cells were significantly increased together with CD

291 ngs from prior studies, frequencies of blood MAIT cells were similar among patients with TB disease a

292 results underscore an important property of MAIT cells, which can be of translational relevance to r

293 ession by phenotypic (CD8(+)CD26(+)CD161(+)) MAIT cells, which constituted the majority (75%) of BCG-

294 ood frequencies of BCG-reactive IFN-gamma(+) MAIT cells, which returned to baseline frequencies a yea

295 etween defined members of the microbiota and MAIT cells, which sequentially controls both tissue-impr

296 tabolites to mucosal associated invariant T (MAIT) cells, which are characterized, in part, by the TR

297 dysfunction, mucosal-associated invariant T (MAIT) cells, which have the capacity to respond to bacte

298 The full-length isoform, MR1A, can activate MAIT cells, while the function of the isoforms, MR1B and

299 However, the interaction of human MAIT cells with adaptive immune responses and the role t

300 There is significant interest in targeting MAIT cells with immunostimulatory agents to enhance immu