ライフサイエンスコーパス: MAPK phosphatase

1 anscription are specifically eliminated by a MAPK phosphatase.

2 SP14; also known as MKP6) is classified as a MAPK phosphatase.

3 sion studies, we established that DUPD1 is a MAPK phosphatase.

4 ding c-Cbl and RasGAP, and more than that of MAPK phosphatase.

5 ogy to the mitogen-activated protein kinase (MAPK) phosphatases.

6 chieve the following: inducing expression of MAPK phosphatase 1 (MKP-1) and p21(Cip1) and decreasing

7 However, the physiological contribution of MAPK phosphatase 1 (MKP-1) as a nuclear antagonist of bo

8 MAPK phosphatase 1 (Mkp-1) deactivates p38 and JNK, abro

9 otein thiol modification and inactivation of MAPK phosphatase 1 (MKP-1), a nuclear phosphatase.

10 eased activation of ERK1/2, stabilization of MAPK phosphatase 1 (MKP-1), and induction of TNF-alpha w

11 d3 inhibited the dephosphorylation of p38 by MAPK phosphatase 1 (MKP-1).

12 action of P(4)/PR, we considered the role of MAPK phosphatase 1 (MKP-1/DUSP1), which catalyzes dephos

13 MAPK phosphatase 1 (MKP1) influences the cellular phenot

14 Here, we show that an Arabidopsis MAPK phosphatase 1 (MKP1) mutant has increased host susc

15 as syringae pv tomato DC3000 and report that mapk phosphatase 1 (mkp1), an Arabidopsis mutant that is

16 erize GR, we found that TNF failed to induce MAPK phosphatase 1 (MKP1).

17 es expression of the GR-dependent model gene MAPK phosphatase 1 in the lung, confirming the dissociat

18 These changes result in MAPK phosphatase 1 stabilization, which shortens and blu

19 Finally, the basal expression of MAPK phosphatase 1, a MAPK-regulated gene involved in re

20 ead C2, hypoxia-inducible factor-1alpha, and MAPK phosphatase 1.

21 The mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an immediate-early gene c

22 including mitogen-activated protein kinase (MAPK) phosphatase 1 (mkp1), which dephosphorylates membe

23 Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-

24 cluding the active homologs of MK-STYX, MKP (MAPK phosphatase)-1 and MKP-3.

25 MAPK phosphatase-1 (DUSP1/MKP-1) is a mitogen and stress

26 MAPK phosphatase-1 (MKP-1) and activated ERK1/2 were mea

27 iuretic peptide increased phosphorylation of MAPK phosphatase-1 (MKP-1) concomitant with inhibited ph

28 MAPK phosphatase-1 (MKP-1) expression was increased upon

29 LVS infection also rapidly induced MAPK phosphatase-1 (MKP-1) expression; PI3K and TLR2 sig

30 The dual specificity protein phosphatase MAPK phosphatase-1 (MKP-1) has been shown to dephosphory

31 MAPK phosphatase-1 (MKP-1) has been shown to dephosphory

32 Overexpression of MAPK phosphatase-1 (MKP-1) in ectoderm inhibited MAPK ac

33 Overexpression of MAPK phosphatase-1 (MKP-1) inhibited p42Erk2 activity an

34 MAPK phosphatase-1 (MKP-1) inhibits the MAPK pathway and

35 MAPK phosphatase-1 (MKP-1) is encoded by mkp-1, a stress

36 ivation leads to both the rapid induction of MAPK phosphatase-1 (MKP-1) mRNA and its sustained expres

37 We also found that MAPK phosphatase-1 (MKP-1) negatively regulates S. pneum

38 expression via specific up-regulation of the MAPK phosphatase-1 (MKP-1) that, in turn, leads to depho

39 ual specificity protein-tyrosine phosphatase MAPK phosphatase-1 (MKP-1) was highly represented in thi

40 Upon vitamin D treatment, the expression of MAPK phosphatase-1 (MKP-1) was significantly upregulated

41 38-inactivating dual specificity phosphatase MAPK phosphatase-1 (MKP-1) were also partially protected

42 d that mapracorat enhanced the expression of MAPK phosphatase-1 (MKP-1), a critical negative regulato

43 in HEK293 cells transient overexpression of MAPK phosphatase-1 (MKP-1), a dual-specificity phosphata

44 pression of the dual specificity phosphatase MAPK phosphatase-1 (MKP-1).

45 possibly through prolonged downregulation of MAPK phosphatase-1 (MKP-1).

46 Adenovirus-mediated adiponectin and MAPK phosphatase-1 (MKP1) overexpression were used to ve

47 Induction of MAPK-dependent genes c-fos and MAPK phosphatase-1 by BHTOOH was also blocked by Ras-N-1

48 e activation of a kinase upstream of JNK) or MAPK phosphatase-1 gene (which dephosphorylates and inac

49 by IFN-gamma was enhanced by overexpressing MAPK phosphatase-1 that inactivates MAPK.

50 which then prevented the ERK activation and MAPK phosphatase-1 up-regulation normally induced by TGF

51 r, the induction and nuclear localization of MAPK phosphatase-1, a factor known to mediate glucocorti

52 ta activated ERK, which in turn up-regulated MAPK phosphatase-1, thereby inactivating p38 MAPK.

53 on of MAPK-dependent genes c-jun, c-fos, and MAPK phosphatase-1.

54 phosphorylation of JNK and the expression of MAPK phosphatase-1.

55 ation of downstream of tyrosine kinase-1 and MAPK phosphatase-1.

56 expression was attenuated in the absence of MAPK phosphatase-1.

57 ion of the mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) have increased fatty acid ox

58 uscle, the mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a critical negative regul

59 Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a member of the MAPK phos

60 Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is the MAPK phosphatase fami

61 ression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereaf

62 -localized mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP1) is upregulated in NASH patien

63 ERK (pERK), protein phosphatase 1 (PP1), and MAPK phosphatase-2 (MKP-2) during adulthood in control a

64 cts as a transcriptional regulator of MKP-2 (MAPK phosphatase-2), a dual specificity protein phosphat

65 sequent TCR stimulation via the induction of MAPK phosphatase 3 (MKP-3).

66 Also, MAPK phosphatase 3, a negative regulator of FGF signalin

67 o identify mitogen-activated protein kinase (MAPK) phosphatase 3 (MKP3) whose expression was correlat

68 Recent studies show that MAPK phosphatase-3 (MKP-3) promotes gluconeogenic gene t

69 m normoxia-exposed cells depleted of PP2A or MAPK phosphatase-3 were also less able to dephosphorylat

70 ted phosphatases (protein phosphatase 2A and MAPK phosphatase-3) demonstrated decreased activity in h

71 PK inhibitors exhibited only partial effect, MAPK-phosphatase-3 expression significantly blocked the

72 as MKP-4 (mitogen-activated protein kinase [MAPK] phosphatase 4), the gene was deleted in mice.

73 lial nitric oxide synthase (eNOS), JNK3, and MAPK phosphatase 7 (MKP7).

74 nregulates mitogen-activated protein kinase (MAPK) phosphatase-7 and enhances phosphorylation of both

75 olled by the balance between MAPK kinase and MAPK phosphatase activities.

76 The activity of one of them the MAPK phosphatase and inhibitor, DUSP14, is counteracted

77 pecificity phosphatases (also referred to as MAPK phosphatases) and thereby inhibits the dephosphoryl

78 Overexpression of MAPK phosphatase CL 100 prevented TGF-beta1 promoter act

79 ole of the mitogen-activated protein kinase (MAPK) phosphatase, dual-specificity phosphatase 1 (DUSP1

80 ht into the regulation of a dual-specificity MAPK phosphatase during meiotic maturation and the adapt

81 n, as direct Notch-mediated transcription of MAPK phosphatase DUSP is lost.

82 ase in the mitogen-activated protein kinase (MAPK) phosphatase DUSP1 following treatment with Ang-(1-

83 nding sites and downstream signaling via the MAPK-phosphatase DUSP1 triggers tau phosphorylation and

84 in p38 MAPK phosphorylation, increase in the MAPK phosphatase, DUSP1, induction of the histone acetyl

85 though the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, mediates dexamethasone-induced

86 ed a number of candidate loci, including the MAPK phosphatase DUSP14 in particular, that are promisin

87 cytokine production of myeloid cells by the MAPK phosphatase Dusp16.

88 P1 knockdown promoted down-regulation of the MAPK phosphatases DUSP4 and DUSP6 via a transcription-ba

89 AS (KRAS(WT)) or decreased expression of the MAPK phosphatase DUSP6 promoted resistance to ALK inhibi

90 We show that the X-linked MAPK phosphatase DUSP9 is upregulated in female compared

91 In this study, we identified the MAPK phosphatase Dusp9/MKP-4 by transcriptome analysis a

92 n kinase (MAPK) phosphatase-1 (MKP-1) is the MAPK phosphatase family member that negatively regulates

93 PK) phosphatase-1 (MKP-1) is a member of the MAPK phosphatase family that functions as a negative reg

94 lights the critical role of dual-specificity MAPK phosphatases in the regulation of developmental out

95 (DUSP1), a mitogen-activated protein kinase (MAPK) phosphatase, in a glucocorticoid receptor (GR)-dep

96 ound that down-regulation of nuclear Pmk1 by MAPK phosphatases induced by the stress activated protei

97 Similarly, a knockdown of WIP1 (a p38 MAPK phosphatase) induced premature senescence that also

98 heart were used here to investigate how this MAPK-phosphatase might regulate intracellular signaling

99 ry, in this study we have identified nuclear MAPK phosphatase MKP-1 as a novel molecular target of RO

100 ed kinase [ERK]1/2) and the dual-specificity MAPK phosphatase MKP-1/DUSP1.

101 s homologs of the mammalian dual-specificity MAPK phosphatases MKP-1/CL100 and found that overexpress

102 n of MKP-1, a stress-inducible member of the MAPK phosphatase (MKP) family of dual specificity protei

103 PKK), a homolog of mammalian MKK7, and VHP-1 MAPK phosphatase (MKP), a homolog of mammalian MKP7, als

104 tivities, at least in part, because of lower MAPK phosphatase (Mkp)-1 activity and greater Syk activi

105 was performed to analyze the involvement of MAPK phosphatase (MKP)-1 in crosstalk.

106 dence of a critical and nonredundant role of MAPK phosphatase (MKP)-1 in the negative control of MAPK

107 MAPK phosphatase (MKP)-1 is an archetypal member of the

108 MAPK phosphatase (MKP)-1 serves as a feedback control me

109 -activated protein kinase (MAPKs) regulator, MAPK phosphatase (MKP)-3, in the resolution of postopera

110 one to (DP)JNK prevented its inactivation by MAPK phosphatase (MKP)-5; however, JNK was still able to

111 ed with an induction of the dual specificity MAPK phosphatases (MKP)-1 and -2, and blockade of MKP in

112 dal lung mRNA was analyzed by microarray and MAPK phosphatases (MKP)-1 quantitative polymerase chain

113 MAPK phosphatases (MKP-1 and/or MKP-5), which are known

114 The mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is overexpressed in a large pr

115 Mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is the major member of MKPs th

116 GRGDSP or mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 small interfering RNA (siRNA)

117 gulated by mitogen-activated protein kinase (MAPK) phosphatases (MKP), which are generally up-regulat

118 The MAPK phosphatase, MKP-1, is capable of inactivating both

119 The MAPK phosphatase MKP1 (DUSP1) is overexpressed in many h

120 MAPK phosphatases (MKPs) are critical modulators of the

121 MAPK phosphatases (MKPs) are dual specificity protein ph

122 MAPK phosphatases (MKPs) are important negative regulato

123 MAPK phosphatases (MKPs) that negatively regulate MAPK a

124 class of dual-specificity phosphatases, the MAPK phosphatases (MKPs), inhibit MAPK signaling by deph

125 in kinases (MAPKs), which are inactivated by MAPK phosphatases (MKPs), represent a central signaling

126 ganisms, are inactivated by dual specificity MAPK phosphatases (MKPs).

127 rotein kinases (MAPKs) are designated as the MAPK phosphatases (MKPs).

128 ch in turn are controlled by redox-sensitive MAPK phosphatases (MKPs).

129 f dual-specificity phosphatases known as the MAPK phosphatases (MKPs).

130 of a family of 10 dual-specificity (Thr/Tyr) MAPK phosphatases (MKPs).

131 MAPK activity is regulated negatively by MAPK phosphatases (MKPs).

132 t least 11 mitogen-activated protein kinase (MAPK) phosphatases (MKPs) and only 3 major groups of MAP

133 Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are dual specificity protein p

134 Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are essential regulators of MA

135 Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) constitute a family of 11 dual

136 pecificity mitogen-activated protein kinase (MAPK) phosphatases (MKPs) directly dephosphorylate and i

137 The mitogen-activated protein kinase (MAPK) phosphatases (MKPs) have been considered "undrugga

138 roach, we found that Slt2 phosphorylates the MAPK phosphatase Msg5 both in the N-terminal regulatory

139 promotion of recovery parallels that of the MAPK phosphatase Msg5.

140 in signaling Sst2 and partially required the MAPK phosphatase Msg5.

141 d the expression/activation of several known MAPK phosphatases not to be affected by PRL, suggesting

142 Elimination of MAPK phosphatases restored more robust outputs for all r

143 ion was attenuated in oocytes expressing the MAPK phosphatase rVH6.

144 s with the mitogen-activated protein kinase (MAPK) phosphatase Sdp1.

145 Here we describe how the stress-inducible MAPK phosphatase, Sdp1, presents an unusual solution to

146 specificity is linked to Kss1 immunity to a MAPK phosphatase that constitutively inhibits basal acti

147 Dual-specificity phosphatase 8 (DUSP8) is a MAPK phosphatase that dephosphorylates and inactivates t

148 pecific, tyrosine-specific phosphatases, and MAPK phosphatase type 1.

149 on of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates

150 these, we have identified a dual-specificity MAPK phosphatase, VHP-1, as a stress-inducible modulator

151 s (PTP1B, CD45, and HePTP), dual specificity MAPK phosphatases (VHR, MKP3, and MKP5), and Ser/Thr pro

152 closely related cytoplasmic dual-specificity MAPK phosphatases, which includes the ERK-specific enzym