ライフサイエンスコーパス: MBT

1 MBT demarcates transition from synchronous short cell cy

2 MBT depletion kinetics in the hydroponic medium with pla

3 MBT depletion rate was related to the initial exposure c

4 MBT repeats are important for the transcriptional repres

5 MBT repeats, domains of approximately 100 amino acids, h

6 MBT values in streams and lake surface water were signif

7 MBT, although more expensive, offers an effective, safe,

8 MBT-1 structurally resembles the H-L(3)MBT protein, whos

9 MBT-1(-/-) myeloid progenitor cells exhibit a maturation

10 nnamic acid), and 2-mercaptobenzothiazole (2-MBT).

11 H-L(3)MBT acts as a histone deacetylase-independent transcript

12 H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL interacting domains.

13 We found that H-L(3)MBT binds in vivo to TEL, and we have mapped the region

14 ulate that the interaction of TEL with H-L(3)MBT can direct a PcG complex to genes repressed by TEL,

15 H-L(3)MBT contains three repeats of 100 residues called MBT re

16 We report that H-L(3)MBT is a transcriptional repressor and that its activity

17 TL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on

18 MBT-1 structurally resembles the H-L(3)MBT protein, whose deletion is predicted to be responsib

19 human homolog of the Drosophila polycomb L(3)MBT tumor suppressor protein and thus a candidate tumor

20 omoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL in

21 ethal (3) malignant brain tumor protein, L(3)MBT, and the histone deacetylase, Rpd3, associated with

22 H-L(3)MBT, the human homolog of the Drosophila lethal(3)malign

23 However, additional MBT and BST had no diagnostic advantage in FM.

24 rst detected at neurula, some 10 hours after MBT, indicating that transcription is significantly dela

25 s are correlated with activation at or after MBT.

26 upon synthesis of zygotic Ago proteins after MBT.

27 ed prior to MBT, but activation of Tcf after MBT cannot rescue ventralized embryos, suggesting that b

28 Although MBT treatment is found to increase the transconductance

29 Cdk1 is sufficient for genome activation and MBT.

30 mL(-1) and 1.37 microg mL(-1) for CN(-) and MBT, respectively.

31 nd a significant correlation between HBT and MBT/BST.

32 endent growth inhibition of murine (MB49 and MBT-2) and human (HT-1376, UM-UC-3, RT-4, J82, and TCCSU

33 ing disease in murine B16/F10.9 melanoma and MBT-2 bladder tumor models.

34 argeted by other E2Fs or by L3MBTL1, another MBT domain-containing protein that interacts with RB1.

35 transcription, while Smad1/5/8 activation at MBT appears to involve transcription-independent regulat

36 ranscripts localize to dorsal blastomeres at MBT.

37 le control in zebrafish embryos commences at MBT and that the reduction of cyclin D1 expression compr

38 A second feature at MBT is a massive increase in zygotic transcription and a

39 zygotic activation of the Xenopus genome at MBT.

40 the onset of Xenopus MARCKS transcription at MBT.

41 ion of immediately early genes in Xenopus at MBT.

42 ria and compared with commercially available MBT BioTargets.

43 global repression and gets activated before MBT.

44 the overall transcriptional silencing before MBT.

45 ain sites of detectable transcription before MBT.

46 ontains three repeats of 100 residues called MBT repeats, whose function is unknown, and a C-terminal

47 lies (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor).

48 ts include glucose and amino acid conjugated MBT metabolites.

49 Arabidopsis seedlings to multiple conjugated-MBT metabolites of differential polarity that accumulate

50 Increasing levels of SSRP1 delay MBT and, surprisingly, accelerate post-MBT cell cycle sp

51 w rational debate on achievable vs desirable MBT-derived SRF quality, informing the development of re

52 accompanied by malignant brain tumor domain (MBT) and sterile alpha motif (SAM) domains.

53 The Drosophila MBT is marked by blastoderm cellularization and follows

54 erable sequence homology with the Drosophila MBT protein (for "mushroom body tiny"), however, which i

55 n (SERS) enhancement factor ratio EF(BDT)/EF(MBT) of approximately 130 was observed uniformly across

56 Our observations support a model for MBT regulation by DNA-based titration and suggest that d

57 The proposed scheme for MBT biosynthesis involves assembly of the MBT backbone b

58 SFMBT1 (Scm [Sex comb on midleg] with four MBT [malignant brain tumor] domains 1) is a poorly chara

59 We have identified human MBT domain-containing protein L3MBTL2 as an integral com

60 The human MBT-1 gene is located on chromosome 6q23, a region frequ

61 To identify MBT regulators, we developed an assay using Xenopus egg

62 -to-cytoplasmic ratio has been implicated in MBT timing, our data show that nuclear size also contrib

63 suggested a role for the N/C volume ratio in MBT timing, none directly tested the effects of altering

64 of these activities plays a broader role in MBT-associated changes than was previously suspected.

65 ings comparable with efficient incineration, MBT, and bioreactor landfilling technologies.

66 9.8% of the initial MBT mass spike was present in the plants after 3 h and d

67 sistent with this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono

68 In LM, MBT differentiated most of the patients correctly and BS

69 mains 1) is a poorly characterized mammalian MBT domain-containing protein homologous to Drosophila S

70 Unlike other mammalian MBT domain proteins characterized to date that selective

71 ide ion (CN(-)) and 2-mercaptobenzothiazole (MBT) in water samples with satisfactory results.

72 2-Mercaptobenzothiazole (MBT) is a tire rubber vulcanizer found in potential sour

73 cridine (9-AA), and 2-mercaptobenzothiazole (MBT) were investigated for lipid detection efficiency in

74 led monolayers (SAMs), 4-methylbenzenethiol (MBT) and pentafluorobenzenethiol (PFBT), are used to inv

75 nzenedithiol (BDT) and 4-methylbenzenethiol (MBT), to form -S/Au and -CH(3)/Au interfaces with essent

76 of PHF20L1 or incubation of a small molecule MBT domain binding inhibitor in cultured cells accelerat

77 yltin (TBT), dibutyltin (DBT), monobutyltin (MBT), and total butyltins (SigmaBT) was analyzed in the

78 The production of mycobactin (MBT) by Mycobacterium tuberculosis is essential for this

79 es two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cMBT), to chelate intracellu

80 arrested two cell cycles prior to the normal MBT activated widespread transcription of the zygotic ge

81 Multiple novel MBT-derived plant metabolites were detected via LC-QTOF-

82 We have engineered the naturally occurring MBT domain repeats of L3MBTL1 to serve as a universal af

83 ttractive platform for the authentication of MBT from diverse samples including forensic and/or archa

84 e DNA-to-cytoplasmic ratio in the control of MBT timing.

85 It is the founding member of a family of MBT domain-containing proteins that has three members in

86 Since the most prominent form of MBT produced by M. tuberculosis lacks this beta-methyl g

87 uantified the plant assimilation kinetics of MBT using Arabidopsis under hydroponic conditions.

88 ble interest in deciphering the mechanism of MBT assembly, with the goal of targeting select biosynth

89 d DNA amount contribute to the regulation of MBT timing with neither parameter being dominant.

90 r size also contributes to the regulation of MBT timing, demonstrating the functional significance of

91 development contribute to the regulation of MBT timing.

92 ing the cell cycle at and around the time of MBT.

93 A rapid transition of MBT vs. temperature/pH relationships occurring at the bo

94 ing TEX86 as a surface temperature proxy, or MBT and/or CBT for reconstructing pH, in anoxic or euxin

95 ency with improved selectivity against other MBT-containing proteins.

96 de a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control

97 C. elegans contains one other MBT-repeat-containing protein, MBTR-1.

98 eport an atomically resolved [Au(52)Cu(72)(p-MBT)(55)](+)Cl(-) nanoalloy (p-MBT = SPh-p-CH(3)).

99 The Au130(p-MBT)50 can be viewed as an elongated version of the Au10

100 Comparison of the Au130(p-MBT)50 structure with the recently discovered icosahedra

101 large gold nanocluster formulated as Au130(p-MBT)50, where p-MBT is 4-methylbenzenethiolate.

102 u(52)Cu(72)(p-MBT)(55)](+)Cl(-) nanoalloy (p-MBT = SPh-p-CH(3)).

103 luster formulated as Au130(p-MBT)50, where p-MBT is 4-methylbenzenethiolate.

104 Our findings highlight a PcG/MBT collaboration that attains repressive chromatin with

105 l alpha-helical structure, the SPM (SCM, PH, MBT domain, which is structurally similar to the SAM (st

106 delay MBT and, surprisingly, accelerate post-MBT cell cycle speed and embryo development.

107 Overexpression of cyclin A2/cdk2 in post-MBT embryos results in increased proliferation specifica

108 Decreasing nuclear size in post-MBT haploid embryos caused a further delay in cell cycle

109 tion of apoptosis in embryos irradiated post-MBT, distinct roles for these complexes during apoptosis

110 Furthermore, zygotically regulated post-MBT events such as cellularization and gastrulation move

111 ng, and the addition of H3/H4 shortened post-MBT cell cycles.

112 at the twelfth cleavage; and a shorter post-MBT wave of transcription that becomes apparent as devel

113 The post-MBT survival mechanism arrests cells in G(1) phase by in

114 ion of Cdc2/Cdk2 on tyr15 occurs in each pre-MBT cell cycle, and dephosphorylation of Cdc2/Cdk2 by Cd

115 by knockdown of mitotic cyclins extended pre-MBT S phase.

116 n given to transcriptional regulation in pre-MBT development.

117 that increasing the N/C volume ratio in pre-MBT embryos leads to premature activation of zygotic gen

118 induced checkpoint response is absent in pre-MBT embryos, introduction of a threshold amount of undam

119 cell cycle and the timing of cleavage in pre-MBT embryos.

120 rsists throughout development, including pre-MBT cell cycles that lack checkpoints.

121 ptosis are evident in embryos irradiated pre-MBT.

122 Persistence of pre-MBT levels of Twine was sufficient to prevent cell-cycle

123 k1 contribute to the speed of the rapid, pre-MBT S phases and that down-regulation of these activitie

124 In the pre-MBT cycles, all genomic regions replicate simultaneously

125 egins early and is maintained throughout pre-MBT stages.

126 -Ser suggests that the megasynthase produces MBT derivatives with beta-methyl oxazoline rings.

127 N/C volume ratio also contributes to proper MBT timing.

128 after brain injury, we show that the revised MBT-r has an excellent inter-rater agreement and has the

129 conserved aspartic acid (D355) in the second MBT repeat.

130 which is relieved at the midblastula stage (MBT).

131 ted MALDI targets are comparable to standard MBT BioTargets and stainless-steel targets and may be us

132 miconazole 50 mg mucoadhesive buccal tablet (MBT) is a novel delivery system with potent in vitro act

133 or suppressor l(3)mbt, contains three tandem MBT repeats (3xMBT) that are critical for transcriptiona

134 d procedure with a modified Blalock-Taussig (MBT) shunt, the first palliative stage for single-ventri

135 instructions on the modified Bass technique (MBT) after their toothbrushing performance was monitored

136 ve identified a putative PcG protein, termed MBT-1, that is associated with Rnf2, an in vivo interact

137 The protein's C-terminal MBT repeats bind mono and dimethylated histones in vitro

138 MEGX concentration, methionine breath test (MBT), galactose elimination capacity (GEC), dual cholate

139 CH(4) breath tests (MBT), blood sugar tests (BST) and clinical symptoms were

140 Together, we conclude that MBT-1 specifically regulates the maturational advancemen

141 del in the frog, Xenopus laevis, posits that MBT timing is controlled by a maternally loaded inhibito

142 -source LC-MS/MS fragmentation revealed that MBT was converted by Arabidopsis seedlings to multiple c

143 We also show that MBT-1 appears to influence myelopoiesis by transiently e

144 The MBT domain is structurally related to protein domains th

145 The MBT domains bind at least two nucleosomes simultaneously

146 The MBT is triggered by a critical nucleocytoplasmic (N/C) r

147 eas the biochemical changes accompanying the MBT in the vertebrate embryo have been extensively docum

148 % of the DTSG (COG, 40%) totally adopted the MBT (P <0.05).

149 In contrast, deleting S phase after the MBT in cycle 15 did not dramatically affect mitotic timi

150 The disappearance of Cdc25A after the MBT may underlie in part the lengthening of the cell cyc

151 is becomes sensitive to nocodazole after the MBT, but not before.

152 mental" activation of Chk1 shortly after the MBT.

153 signal only in embryos irradiated after the MBT.

154 tiple mechanisms prevent apoptosis after the MBT.

155 tive effect against apoptosis only after the MBT.

156 e, DNA damage activates XChk1 only after the MBT.

157 turbed cell cycle before, but not after, the MBT.

158 l cycle slowing as the embryo approaches the MBT permits increasing accumulation and action of Eggles

159 ding protein (TBP) increases robustly at the MBT and that the mechanism underlying this increase is t

160 hat Xenopus Claspin is phosphorylated at the MBT at both DNA replication checkpoint-dependent and -in

161 collaborate to control the cell cycle at the MBT by directly mediating the normal repression of mater

162 At the MBT in embryos, Chk1 is transiently activated to lengthe

163 he nuclear translocation of CBTF(122) at the MBT is likely to be coupled to the degradation of matern

164 Not all phosphorylation that occurs at the MBT is reproduced in egg extracts.

165 ivation of the checkpoint kinase Chk1 at the MBT results in the SCF(beta-TRCP)-dependent degradation

166 chronous nuclear divisions must pause at the MBT to allow the formation of a cellular blastoderm thro

167 roper levels of zygotic transcription at the MBT, and that genes activated in the second wave of expr

168 At the MBT, down-regulation of Cdc25 phosphatase and the result

169 At the MBT, embryonic transcription is upregulated and cell cyc

170 e activation of zygotic transcription at the MBT, including expression of the gene tribbles, whose ac

171 contributes to the cell-cycle change at the MBT, including the addition of a G2 phase and onset of l

172 The cell cycle changes at the MBT, including the addition of gap phases and checkpoint

173 At the MBT, S phase is dramatically lengthened by the onset of

174 This site becomes hyperphosphorylated at the MBT, thus allowing the docking of proteins required for

175 Smicl might regulate gene expression at the MBT, we have discovered that it interacts with the tail

176 Although XChk1 mRNA is degraded at the MBT, XChk1 protein persists throughout development, incl

177 to the elimination of its transcripts at the MBT.

178 y programmed down-regulation of Cdc25 at the MBT.

179 robust activation of Nodal signaling at the MBT.

180 otic transcription of N/C ratio genes at the MBT.

181 iate high-level zygotic transcription at the MBT.

182 induces a novel Chk2-dependent block at the MBT.

183 nal to zygotic control of development at the MBT.

184 has an additional essential function at the MBT.

185 n B bypass the requirement for mei-41 at the MBT.

186 uired to terminate the cleavage stage at the MBT.

187 (bp) repeat sequence, recruited HP1a at the MBT.

188 A-to-cytoplasm ratio found in embryos at the MBT.

189 role in early Xenopus development before the MBT as a direct transcription repressor protein.

190 tein coding transcripts activated before the MBT by the maternal T-box factor VegT that are component

191 se organisms that are transcribed before the MBT, but whether precocious expression of specific mRNAs

192 Before the MBT, each cycle is composed of only a short S phase and

193 embryos facilitates transcription before the MBT, without requiring TBP to be prebound to the promote

194 s on the transcriptional capacity before the MBT.

195 o contribute to promoter activity before the MBT.

196 he seventh cleavage and extending beyond the MBT at the twelfth cleavage; and a shorter post-MBT wave

197 e of mature myeloid blood cells, causing the MBT-1(-/-) mice to die of anemia during a late embryonic

198 mechanism for how the N/C ratio controls the MBT and shows that the regulation of replication initiat

199 nd point to similar mechanisms governing the MBT in diverse species.

200 biochemical purification, we identified the MBT domain-containing protein SFMBT1 as a novel componen

201 chromatin-associated modules, including the MBT-like repeat, Tudor, and PWWP domains.

202 the DNA damage response as an element of the MBT and indicate that multiple mechanisms prevent apopto

203 or MBT biosynthesis involves assembly of the MBT backbone by a hybrid nonribosomal peptide synthetase

204 matin involves the coordinated action of the MBT domains, RNA binding, and interaction with PRC1 thro

205 active Nodal signaling, at the onset of the MBT requires preMBT transcription and activity of xnr5 a

206 targeted for degradation at the onset of the MBT through a switch-like mechanism controlled, like Str

207 lation of a maternal mRNA at the time of the MBT, as suggested previously.

208 hese factors regulate multiple events of the MBT, including the slowing of the cell cycle, the onset

209 s critical for controlling the events of the MBT.

210 logical timers that control the onset of the MBT.

211 zfAPEX1a intron-exon junctions also pass the MBT with similar abnormalities.

212 endogenous protein in the cytoplasm past the MBT, indicating that cytoplasmic retention is a phosphor

213 hat the proper number of mitoses precede the MBT.

214 hat depletion of free histones regulates the MBT.

215 two MBT (malignant brain tumor) repeats; the MBT is a protein module structurally similar to domains

216 These results demonstrate that the MBT domain of PHF20L1 reads and controls enzyme levels o

217 These results suggest revisions to the MBT biosynthesis pathway while also identifying new targ

218 wood procedure were randomly assigned to the MBT shunt (275 infants) or the RVPA shunt (274 infants)

219 enopus embryos lack checkpoints prior to the MBT, checkpoints are observed in cell-free egg extracts

220 ts by RNAi did not affect progression to the MBT.

221 after stage 7, two cell cycles prior to the MBT.

222 the N/C volume ratio increases prior to the MBT.

223 spond to an independent timer to trigger the MBT and activation of cell cycle checkpoints.

224 ne protein was abundant and stable until the MBT, when it was destabilized and rapidly eliminated.

225 tact but blocked upstream of XChk1 until the MBT.

226 At T0, 27.27% of DTSG participants used the MBT correctly (COG, 50%), increasing to 54.55% (COG, 60%

227 was higher with the RVPA shunt than with the MBT shunt (74% vs. 64%, P=0.01).

228 was better with the RVPA shunt than with the MBT shunt.

229 compatible with models suggesting that these MBT events are directly coupled to N/C.

230 he presence of a region containing the three MBT repeats.

231 tributions of nuclear size and DNA amount to MBT timing by simultaneously altering nuclear size and p

232 dependent transcription is required prior to MBT for dorsal-ventral patterning in XENOPUS:

233 ependent transcription is activated prior to MBT, but activation of Tcf after MBT cannot rescue ventr

234 The revised Motor Behavior Tool (MBT-r) is a clinical complementary tool aiming to identi

235 not begin until the mid-blastula transition (MBT) 3 h after fertilization.

236 tic cell cycle, the mid-blastula transition (MBT) and at gastrulation.

237 phila embryo at the mid-blastula transition (MBT) concurrently experiences a receding first wave of z

238 emporarily deferred mid-blastula transition (MBT) events.

239 equences during the mid-blastula transition (MBT) in Drosophila.

240 ranscription at the mid-blastula transition (MBT) in the suppression of apoptosis in normal embryos.

241 pus development the mid-blastula transition (MBT) marks a dramatic change in response of the embryo t

242 The Xenopus mid-blastula transition (MBT) marks the onset of large-scale zygotic transcriptio

243 ent features at the mid-blastula transition (MBT) observed in most embryos is a pause in cell cycle r

244 referred to as the mid-blastula transition (MBT) remain mysterious.

245 1 protein decays at mid-blastula transition (MBT) when asynchronous somatic cell cycles start.

246 At the mid-blastula transition (MBT), externally developing embryos refocus from increas

247 At the mid-blastula transition (MBT), the cell cycle elongates and several processes bec

248 mbryos prior to the mid-blastula transition (MBT), whereas multivalent genes are correlated with acti

249 ream targets at the mid-blastula transition (MBT).

250 hylation before the mid-blastula transition (MBT).

251 n occurs before the mid-blastula transition (MBT).

252 n delayed until the mid-blastula transition (MBT).

253 but not before, the mid-blastula transition (MBT).

254 orphogenesis at the mid-blastula transition (MBT).

255 sition known as the mid-blastula transition (MBT).

256 laevis embryos, the midblastula transition (MBT) at the 12th cell division marks initiation of criti

257 sophila embryos, the midblastula transition (MBT) dramatically remodels the cell cycle during the 14(

258 At the midblastula transition (MBT) during Xenopus laevis development, zygotic transcri

259 f development at the midblastula transition (MBT) follows mitosis 13, when the cleavage divisions ter

260 erved feature of the midblastula transition (MBT) is a requirement for a functional DNA replication c

261 The midblastula transition (MBT) is the first morphological event that requires zygo

262 il to undergo timely midblastula transition (MBT) or arrest following ionizing radiation.

263 of expression at the midblastula transition (MBT) requires Smicl and is correlated with the transloca

264 at approximately the midblastula transition (MBT) without apoptosis.

265 The Drosophila midblastula transition (MBT), a major event in embryogenesis, remodels and slows

266 ntinuously until the midblastula transition (MBT), after which it is degraded.

267 nt terminates at the midblastula transition (MBT), at which point the cell cycle slows dramatically,

268 At the Xenopus midblastula transition (MBT), cell cycles lengthen, and checkpoints that respond

269 visions pause at the midblastula transition (MBT), coinciding with a dramatic increase in gene transc

270 are followed by the midblastula transition (MBT), during which the cell cycle elongates and zygotic

271 on factors after the midblastula transition (MBT), including a marked decline of the licensing factor

272 quiescent until the midblastula transition (MBT), when large-scale transcription begins.

273 divisions marks the midblastula transition (MBT), when the cell cycle lengthens, acquiring gap phase

274 al transition is the midblastula transition (MBT), when zygotic transcription begins and cell cycles

275 yclin E prior to the midblastula transition (MBT), with or without cdk2, results in a loss of nuclear

276 divisions until the midblastula transition (MBT).

277 of pre-miRNAs at the midblastula transition (MBT).

278 les slow down at the midblastula transition (MBT).

279 s cell cycles at the midblastula transition (MBT).

280 , but not after, the midblastula transition (MBT).

281 iption begins at the midblastula transition (MBT).

282 cytoplasm before the midblastula transition (MBT).

283 ing a maximum at the midblastula transition (MBT).

284 aintained during the midblastula transition (MBT).

285 kpoints comprise the midblastula transition (MBT).

286 pear until after the midblastula transition (MBT; 4000 cells).

287 produced by mechanical-biological treatment (MBT) of municipal waste can replace fossil fuels, being

288 ection of a mechanical-biological treatment (MBT) plant producing solid recovered fuel (SRF) for the

289 cineration, mechanical-biological treatment (MBT), and landfilling).

290 Malignant brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 14

291 K382me1 by the triple malignant brain tumor (MBT) repeats of the chromatin compaction factor L3MBTL1.

292 which contains three malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysi

293 tein composed of four malignant brain tumor (MBT) repeats.

294 demonstrate that the malignant-brain-tumor (MBT) protein L3MBTL1 is in a complex with core histones,

295 n of endangered species, Malayan box turtle (MBT) (Cuora amboinensis).

296 It contains two MBT (malignant brain tumor) repeats; the MBT is a protei

297 ng the decrease in cyclin/Cdk1, we uncoupled MBT from N/C increase, arguing that N/C-guided down-regu

298 e current therapy using in vitro and in vivo MBT-2 murine tumor models.

299 molecular events in precise accordance with MBT morphological progression.

300 t cell cycle remodeling during the zebrafish MBT includes the transcription-independent acquisition o