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1                                              MEN2A is a dominantly-inherited cancer predisposition sy
2 s with multiple endocrine neoplasia type 2A (MEN2A) and familial medullary thyroid carcinoma (FMTC) c
3        Multiple endocrine neoplasia type 2A (MEN2A) is predisposed by mutations in the RET proto-onco
4  drive multiple endocrine neoplasia type 2A (MEN2A), a hereditary syndrome associated with the develo
5 ndrome multiple endocrine neoplasia type 2A (MEN2A).
6 or for multiple endocrine neoplasia type 2A (MEN2A).
7  that induction of the constitutively active MEN2A-specific RET mutant, RET2A(C634R), correlates with
8  protein previously associated with FMTC and MEN2A, it is very likely that they represent mutations t
9 rranged during Transfection (RET) gene cause MEN2A, MEN2B, and familial medullary thyroid carcinoma (
10     We have developed a Drosophila model for MEN2A and MEN2B diseases by targeting oncogenic forms of
11 d by germline mutations in the RET (formerly MEN2A, MEN2B) proto-oncogene located on chromosomal band
12 to construct mice in which the most frequent MEN2A mutation, Cys-634-Arg, was expressed under the con
13 ivating germline mutations observed in human MEN2A and familial MTC (FMTC).
14  between G691S/S904S and modifier effects in MEN2A families in any of the four European families anal
15  membrane of cysteine residues implicated in MEN2A and MTC syndromes.
16 tential key mechanism of cancer induction in MEN2A, both in the absence and presence of its native li
17 T(C634R) mutant, the most common mutation in MEN2A.
18  a cysteine replacement that is prevalent in MEN2A cases - the A639G/A641R mutations significantly re
19 ns of RET lead to other conditions including MEN2A, familial medullary thyroid carcinoma and intestin
20 C) and type 2A multiple endocrine neoplasia (MEN2A), mutations of cysteine residues in the extracellu
21 ing the cysteine-rich region of the protein (MEN2A-like mutations) are correlated with different phen
22                  Perhaps most significantly, MEN2A adrenal tumors also display these changes in cell
23 ause multiple endocrine neoplasia syndromes (MEN2A and MEN2B).
24      The RET point mutations associated with MEN2A, MEN2B, or FMTC, or the chromosomal breakpoints an
25            Also, children from families with MEN2A, MEN2B, or FMTC, who are found to have inherited a
26 eventive thyroidectomies on 50 patients with MEN2A (group A).
27                             In patients with MEN2A treated by preventive total thyroidectomy routine
28 re significantly deregulated in tumours with MEN2A-like and MEN2B-like mutations; however, further in
29 ositive weak effect on tumor spectrum within MEN2A, which requires replication in a larger series.