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1 MIC allele profiles were determined in a discovery cohor
2 MIC and disk diameter results were interpreted using Uni
3 MIC determinations were performed retrospectively for th
4 MIC distributions and susceptibilities were also compare
5 MIC of colistin (4 mug/ml) for DH5alpha containing mcr-3
6 MIC values for agar dilution, Etest, and MTS were not si
7 MIC, pDST and whole genome sequencing of the pncA, rpsA
8 MIC-treated patients showed the Immune Tolerance Network
9 MICs for macrolide-susceptible M. pneumoniae (MSMp) were
10 MICs inhibiting 50 and 90% of organisms (MIC(50) and MIC
11 MICs were determined in triplicate via reference broth m
12 MICs were evaluated visually and interpreted using Clini
13 MICs were interpreted according to the investigational C
14 I trial, patients received either 1.5 x 106 MICs per kg BW on day -2 (n = 3, group A), or 1.5 x 108
15 BW on day -2 (n = 3, group A), or 1.5 x 108 MICs per kg BW on day -2 (n = 3, group B) or day -7 (n =
16 i MG1655:: tetA grown in the presence of 1/2 MIC (14 mg/L) of OTC, and for comparison WT MG1655 strai
18 ocycline susceptibility results (+/-1 log(2) MIC agreement) of AXDX MICs with reference broth microdi
19 ic-pharmacodynamic studies identify fAUC0-24/MIC ratio as the parameter that correlates with in vivo
22 resistance breakpoint our results suggest a MIC of 32 mg/L to be considered in order to detect isola
24 C (MIC(50) = 0.25 mug/ml) and mithramycin A (MIC(50) = 0.015 mug/ml), and the naturally derived tetra
25 that the laboratory can generate an accurate MIC that is reproducible within one interpretive categor
26 training sets, we show that highly accurate MIC prediction models can be generated with less than 50
28 w approach provides quantitative, actionable MIC results within just 5 h because it measures electric
29 ones, evaluated their antifungal activities (MIC(80) and time-kill profile) against C. neoformans, an
30 ifficile agents with ultrapotent activities [MICs as low as 0.003 mug/mL (0.007 muM)] that surpassed
31 3.3 showed the greatest antibiotic activity (MIC = 15.6 mug/mL) against Gram-positive bacteria and gr
32 ted activity against Pseudomonas aeruginosa (MIC 16 ug/mL) and Staphylococcus aureus (MIC 64 ug/mL).
34 but gradient diffusion strips identified an MIC of >=4 for colistin for only 62.5% of these isolates
38 er) than the community isolates (MIC(50) and MIC(90) of 0.5 mg/liter), a finding that was consistent
39 ed higher CPT MIC distributions (MIC(50) and MIC(90) of 2 mg/liter) than the community isolates (MIC(
40 ibiting 50 and 90% of organisms (MIC(50) and MIC(90), respectively), essential agreement (EA), catego
42 e aimed to assess the impact of PZA gDST and MIC on time to sputum culture conversion (SCC) and treat
44 ), Etest (bioMerieux, Inc., Durham, NC), and MIC test strip (MTS) (Liofilchem, Inc., Waltham, MA) met
45 Susceptibility rates, MIC(50) values, and MIC(90) values were as follows: ceftazidime-avibactam, 9
50 These consensus guidelines recommend an AUC/MIC ratio of 400-600 mg*hour/L (assuming a broth microdi
52 rve to minimum inhibitory concentration (AUC/MIC) thresholds previously found to be associated with l
54 separately as co-primary endpoints, were AUC/MIC by broth microdilution >=650 and AUC/MIC by Etest >=
58 over minimal inhibitory concentration (AUC24/MIC) ratios, and emergence of resistance were studied.
59 over minimal inhibitory concentration (AUC24/MIC) ratios, and emergence of resistance were studied.
60 derived tetracycline derivative, aureomycin (MIC(50) = 0.06 mug/ml), exhibited potent activity agains
61 against multiresistant Staphylococcus aureus MIC = 5 mg/mL) and no cytotoxicity against carcinogenic
63 ) and Harungana madagascariensis (S. aureus: MIC: 32 mug/mL; E. faecium: MIC: 32 mug/mL) stem bark.
64 anthoxylum chalybeum (Staphylococcus aureus: MIC: 16 mug/mL; Enterococcus faecium: MIC: 32 mug/mL) an
66 results (+/-1 log(2) MIC agreement) of AXDX MICs with reference broth microdilution was 98.0% (96/98
69 h of both CRAB and susceptible A. baumannii (MIC 64-256 ug/mL), and also exhibited activity against P
70 sensitivity and specificity of a bedaquiline MIC susceptibility breakpoint of 0.12 mug/ml for the BMD
71 d reproducibility of provisional bedaquiline MIC breakpoints and World Health Organization interim cr
72 (Bregs) increased from a median of 6% before MIC infusion to 20% on day 180, which was 19- and 68-fol
73 l resistance to penicillin (benzylpenicillin MIC >= 256 mug/ml), beta-lactam/beta-lactamase inhibitor
75 illin/tazobactam non-susceptible breakpoint (MIC > 16 mg/L) best predicted 30-day mortality after acc
76 in the presence of serum and whole blood by MIC and minimal bactericidal concentration (MBC) determi
77 concept, botanical samples were digested by MIC-DV for further determination of Al, Cr, Cu, Fe, Mn,
81 ess on the fate of myeloma initiating cells (MICs), we develop a systems biological model to reveal t
82 an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression aga
84 tance mechanisms, and 128 isolates with CFDC MICs of >=8 mug/ml obtained from International Health Ma
85 t decades, and molecular information coding (MIC) on those designed nanostructures has gained increas
86 MicroScan colistin well displayed a colistin MIC of >=4 by BMD, all were determined to be negative fo
89 such, the results for isolates with colistin MICs of 2 ug/ml by CBDE should be confirmed by the refer
90 PmB (MICs 384-1024 ug ml(-1) ) and colistin (MIC 256 ug ml(-1) ) as well as enhanced LL-37 resistance
93 us aureus [minimum inhibitory concentration (MIC) = 4 ug/mL], while the blue benzoquinone is active a
94 meropenem minimum inhibitory concentration (MIC) and beta-lactam resistance genes with mortality in
95 erform the minimum inhibitory concentration (MIC) assays, which indicated that frtP upregulation led
100 al test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibi
102 d that the minimum inhibitory concentration (MIC) of RSM-932A and MN58b for S. pneumoniae was 0.4 muM
103 reased the minimum inhibitory concentration (MIC) of S. aureus towards vancomycin by 75%, and resulte
106 urve (AUC)/minimum inhibitory concentration (MIC) to ensure clinical efficacy and minimize toxicity i
108 idomycins (minimum inhibitory concentration (MIC) values around 2.5 muM), with several analogs thus a
112 bition and minimum inhibitory concentration (MIC) with that of nisin A and its antimicrobial effect i
118 minimum inhibitory/biocidal concentrations (MIC/MBC), and disc diffusion assays against Meticillin-r
120 g2 showed minimum inhibitory concentrations (MIC) down to 15.6 umol/L and were thus 10-1,000-fold mor
122 , and the minimum inhibitory concentrations (MIC) were then determined via simple colorimetric reacti
123 cidal and minimal inhibitory concentrations (MIC), are independent of bacterial resistance pattern, p
124 ed potent minimum inhibitory concentrations (MICs) against canine S. pseudintermedius and P. aerugino
125 tric mean minimum inhibitory concentrations (MICs) as the outcome variables (from 2010 to 2016).
130 mpared to minimal-inhibitory concentrations (MICs) in laboratory media, AZM had a 16-fold lower MIC i
131 measured minimum inhibitory concentrations (MICs) to ciprofloxacin, cefixime, ceftriaxone, and cefpo
132 bacterial minimum inhibitory concentrations (MICs) were used to determine therapeutic versus subthera
133 ded the lowest error rates, but confirmatory MIC testing is indicated for isolates with inhibition zo
134 z holder (a modified version of conventional MIC) placed inside disposable polypropylene (PP) vessels
137 d Cox proportional hazard models correlating MICs, DST results, and clinical variables to tSCC and tr
138 e countries (HICs), middle-income countries (MICs), and low-income countries (LICs) with standardised
139 tal-associated isolates exhibited higher CPT MIC distributions (MIC(50) and MIC(90) of 2 mg/liter) th
143 p, here we developed a droplet-based digital MIC screen that constitutes a practical analytical platf
144 M23-defined tier 2 study, the agar dilution MIC QC range for zoliflodacin against the Neisseria gono
145 ates exhibited higher CPT MIC distributions (MIC(50) and MIC(90) of 2 mg/liter) than the community is
146 insic resistance to fluconazole and elevated MIC to voriconazole (81%), amphotericin B (61%), flucyto
150 ureus: MIC: 16 mug/mL; Enterococcus faecium: MIC: 32 mug/mL) and Harungana madagascariensis (S. aureu
151 r enterococcal bacteremia, a daptomycin fAUC/MIC >27.43 was associated with 30-day survival among low
152 concentration-time curve to MIC ratio (fAUC/MIC) threshold predictive of survival at 30 days was ide
153 all the telomeres or centromeres on the five MIC chromosomes clustering together, respectively, which
154 ty of fosfomycin is the specified method for MIC determination, namely, agar dilution, which is not w
155 ed potency against clinical VRE strains from MIC = 2 mug/mL (acetazolamide) to MIC = 0.007 mug/mL (22
158 contemporary cohort of adults from 21 HICs, MICs, and LICs across five continents by use of standard
162 voriconazole exhibited significantly higher MICs against isolates of the South African lineage than
163 een baseline and follow-up by the identified MIC (0.301) reported lower treatment satisfaction at fol
164 ent model indicated that a small increase in MIC might decrease the efficacy of vancomycin in clearin
168 to those from cancer was 0.4 in HICs, 1.3 in MICs, and 3.0 in LICs, and four upper-MICs (Argentina, C
169 ed for only 23% of deaths in HICs (vs 41% in MICs and 43% in LICs), despite more cardiovascular disea
170 ICs (7.1 cases per 1000 person-years) and in MICs (6.8 cases per 1000 person-years) than in HICs (4.3
171 rythromycin and tetracycline, differences in MICs between WT and DeltaTolC mutant strains were not re
173 per 1000 person-years) were double those in MICs (6.9 deaths per 1000 person-years) and four times h
175 ated with Neisseria species having increased MICs to cefixime, ceftriaxone, and cefpodoxime (mean MIC
178 mpounds that exhibited bacterial inhibition (MIC) and killing (MBC) activities up to 65 folds higher
179 of 2 mg/liter) than the community isolates (MIC(50) and MIC(90) of 0.5 mg/liter), a finding that was
181 g with initial zinc availability (i.e., less MIC reduction with higher initial zinc concentrations),
182 eller Hinton broth (MHB) and a 64-fold lower MIC in this tissue culture medium with 20% human serum.
183 in laboratory media, AZM had a 16-fold lower MIC in tissue culture medium with 5% Mueller Hinton brot
185 5.5% [44.8-46.4] 2015 GNI for LICs and lower-MICs combined) and interventions delivered in health cen
186 9.8% [49.5-50.2] 2015 GNI for LICs and lower-MICs combined) would each comprise the plurality of cost
193 tibility rate overall (92.7%) and the lowest MIC(90) value (4 mg/liter) of any of the 12 agents teste
194 disposable vessels and instrumentation, make MIC-DV suitable to be used for research and routine anal
195 cefixime, ceftriaxone, and cefpodoxime (mean MIC ratios of 6.27, 4.11, and 7.70, respectively), compa
196 ized the Neisseria species and compared mean MIC levels between different antibiotic user groups.
197 ion of cephalosporins and the geometric mean MICs of ceftriaxone and cefixime (P < .05 for both compa
200 recently described Drosophila tau(KO) and Mi{MIC} mutants and focused on molecular and behavioral ana
201 M23 tier 2 study design, broth microdilution MIC and disk diffusion quality control (QC) ranges were
202 00 mg*hour/L (assuming a broth microdilution MIC of 1 mg/L) to achieve clinical efficacy and ensure s
206 acronucleus (MAC) and germline micronucleus (MIC) of Tetrahymena thermophila differ in chromosome num
207 aluation of MICs in the context of the modal MIC for Enterobacterales and Pseudomonas aeruginosa, the
208 ovel parallel match scoring algorithm, named MIC-SDP (spectrum dot product), and its two-level parall
213 non-extruded samples showing high values of MIC and MBC as the microorganisms tested were multi-resi
214 d Pseudomonas aeruginosa, the variability of MIC tests, and, possibly, resistance mechanisms is impor
219 BL-harboring isolates, the impact of EDTA on MICs was dependent on the lot, correlating with initial
221 MICs inhibiting 50 and 90% of organisms (MIC(50) and MIC(90), respectively), essential agreement
223 , Fgd1 (DLM), and Rv0678 (BDQ) and performed MIC assays on a subset of MTBc strains carrying mutation
224 hesis- did not affect resistance phenotypes (MIC and growth rate with OTC), while blocking of protein
225 ies that showed near total resistant to PmB (MICs 384-1024 ug ml(-1) ) and colistin (MIC 256 ug ml(-1
227 ]pyrimidin-4(3H)-one) with improved potency (MIC = 19/38 muM), selectivity over normal gut microflora
231 e also show that our approach for predicting MICs is stable over time, despite annual fluctuations in
237 A two-fold decrease in dilutions of PZA MIC for PZA susceptible strains showed no association wi
239 provides a platform for developing reference MIC assays that are robust against inoculum-density vari
240 compatibility complex class I chain-related (MIC) A and B (MICA and MICB) are polymorphic stress mole
243 00%, 81% and 18% of patients at respectively MIC of 0.063, 0.125 and 0.25 mg/L achieved AUC24/MIC >=1
244 , 81%, and 18% of patients at, respectively, MIC of 0.063, 0.125, and 0.25 mg/L achieved AUC24/MIC >=
246 st A. fumigatus and B. dendrobatidis showing MIC values of 62.50 ug/mL and 31.25 ug/mL, respectively.
247 uated for colistin resistance using standard MIC testing by both agar dilution and broth microdilutio
249 activity against both the drug-susceptible (MIC = 0.0039 mug/mL) and drug-resistant Mtb strains (MIC
254 ciated with elevated piperacillin/tazobactam MICs and the highest risk increase in 30-mortality of 14
260 and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isoge
261 and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isoge
262 oderate doses of antibiotics, well below the MIC of resistant strains, may effectively restrict de no
263 , respectively) were tested to determine the MIC of the strains as well as the heterogeneity in growt
264 entify three critical proteins governing the MIC proliferation and death, including FAK, mTORC1 and N
265 boundaries of the TAD-like structures in the MIC are highly consistent with the chromatin breakage se
268 oeugenol caused significant reduction in the MIC of the antibiotic, demonstrating synergistic effects
271 ggesting that each TAD-like structure of the MIC chromosomes develops into one MAC chromosome during
273 (every 24 hours) dose was 1.5%-5.5% when the MIC was 4 mg/L (ie, daptomycin-susceptible) and 91.0%-97
275 y to describe the dynamic regulations of the MICs, but also clearly identify three critical proteins
280 ur susceptibility threshold in comparison to MIC across 64 more isolates confirmed the reliability of
281 g area under the concentration-time curve to MIC ratio (fAUC/MIC) threshold predictive of survival at
283 s active against Mycobacterium tuberculosis (MIC = 4 ug/mL) and even against a multidrug-resistant (M
284 1.3 in MICs, and 3.0 in LICs, and four upper-MICs (Argentina, Chile, Turkey, and Poland) showed ratio
288 ve-induced combustion in disposable vessels (MIC-DV) for trace elements determination by inductively
289 or the approved dose are optimized only when MIC <=1 mg/L, these data continue to stress the importan
296 resulted in a library of >50 compounds with MICs ranging from 3 to 800 muM against clinical isolates
297 the reference BMD method, and isolates with MICs of >=2 ug/ml should be evaluated for the presence o