ライフサイエンスコーパス: MMTV

1 MMTV Gag localizes to discrete cytoplasmic foci in mouse

2 MMTV isolated from infected mice lacking these LBPs cann

3 MMTV-bound bacterial lipopolysaccharide triggered Toll-l

4 MMTV-Cre- or adenoviral-Cre-mediated SmoM2 expression in

5 MMTV-Cre;NRP2(loxP/loxP) mice exhibited significant defe

6 MMTV-Espl1 mice in a C57BL/6 genetic background develop

7 MMTV-LTR promoter-driven HA-14-3-3zeta transgenic mice (

8 MMTV-miR-489 mice that overexpressed miR-489 in mammary

9 MMTV-neu;Nedd9(-/-) mammospheres had striking defects in

10 MMTV-PREX1 expression in MMTV-neu mice increased tumor i

11 MMTV-SP uses endoplasmic reticulum-associated degradatio

12 MMTV/Wnt-1 x MMTV/GPNMB bigenic mice also exhibit a sign

13 mapping, indicated that, similarly to HIV-1, MMTV uses a myristic switch to anchor the MA to the memb

14 Crossing C57BL/6 MMTV-PyMT mice, which spontaneously develop mammary carc

15 ent ITAM-containing proteins, one encoding a MMTV provirus and the other a B cell receptor fusion pro

16 oteins from an immortalized cell line from a MMTV-neu mouse model and from MCF7 human breast cancers

17 Deletion of Fgf13 in a MMTV-PyMT breast cancer cell line reduces colonization o

18 ession during breast cancer progression in a MMTV-PyMT transgenic mouse model.

19 An MMTV-Cre driver was used to target knockout to the epith

20 MMTV Gag and YB-1 was RNA dependent, and an MMTV RNA reporter construct colocalized with Gag and YB-

21 Using both human breast tumor cells and an MMTV-Wnt mouse breast tumor model, we show that RKIP ind

22 of our MT prostate model with those from an MMTV-MT breast model (23) shows both tissue-specific and

23 e expression from E2F2 knockout tumors in an MMTV-Neu background.

24 to-mesenchymal transition and metastasis, an MMTV-PyMT transgenic mouse model of mammary tumour progr

25 ratin 5-Cre recombinase (K5-Cre) cross or an MMTV-NIC mouse, we investigated the impact of PRMT overe

26 Here, using an MMTV-PyMT mouse mammary tumor model, we discovered that

27 g a floxed Ccn6 mouse which was bred with an MMTV-Cre mouse.

28 A floxed NRP2 mouse was bred with an MMTV-Cre strain to generate a mammary gland-specific kno

29 In summary, HIV-1 and MMTV share common features such as membrane binding of t

30 ys in tumors derived from the MMTV/Wnt-1 and MMTV/Wnt-1 x MMTV/GPNMB mice using RPPA analysis.

31 of the immunosuppressive cytokine IL-10 and MMTV evasion of host immunity.

32 creased apoptosis were seen in MMTV-HER2 and MMTV-Neu mammary glands lacking ErbB3, thus inhibiting p

33 and reduced latency in both DMBA-induced and MMTV-Erbb2/Neu mouse mammary tumor models compared to P7

34 of cancer (RIP1-Tag2 model of insulinoma and MMTV-PyMT model of breast cancer).

35 We tested the Env proteins of JSRV and MMTV, as well as human endogenous retrovirus K (HERV-K)1

36 mouse models of breast cancer, MMTV-Neu and MMTV-PyMT.

37 ce is replicated faithfully in MMTV-PyMT and MMTV-Her2 transgenic mouse models of breast cancer.

38 ioned media (CM) obtained from MMTV-PyMT and MMTV-Her2/Neu tumor cells cultured in vitro were suffici

39 mouse mammary tumor virus (MMTV)- PyMT- and MMTV- Wnt1-driven mammary tumorigenesis and metastasis.

40 rom GFPRem dramatically reduced both Rem and MMTV-SP levels and function.

41 determines cleavage, retrotranslocation, and MMTV-SP function.

42 egulation of cap-independent translation and MMTV-induced tumorigenesis contrasts with the well estab

43 deamination was important for APOBEC3's anti-MMTV activity.

44 tumor virus-polyoma virus middle T antigen (MMTV-PyMT)-induced breast cancer to conduct such an eval

45 AQP1(+/+) MMTV-PyVT mice developed large breast tumors with total

46 +/-1/mouse) was much lower than in AQP1(+/+) MMTV-PyVT mice (31+/-8/mouse, P<0.005).

47 , 12 mice) were greatly reduced in AQP1(-/-) MMTV-PyVT mice (P<0.005).

48 ression was increased in tumors in AQP1(-/-) MMTV-PyVT mice.

49 microvascular anatomy in tumors of AQP1(-/-) MMTV-PyVT mice, with reduced vessel density.

50 To allow detection and localization of both MMTV-SP and the C-terminal cleavage product, we prepared

51 LTR of the mouse mammary tumor virus (147 bp MMTV-A).

52 fap2c, in mouse mammary epithelium driven by MMTV-Cre promoted aberrant growth of the mammary tree le

53 t mechanistic breast cancer models driven by MMTV-Wnt1 and a human head and neck squamous cell carcin

54 Conditional knockout of Runx1 in MECs by MMTV-Cre led to a decrease in luminal MECs, largely due

55 o widely used mouse models of breast cancer, MMTV-Neu and MMTV-PyMT.

56 s in a mouse model of luminal breast cancer, MMTV-PyMT, leads to a profound increase in lung metastas

57 in MMTV-miR-22 TG mice, as well as compound MMTV-neu or -PyVT-miR-22 TG mice.

58 Rnf5-deficient MMTV-PyMT mammary tumors were less differentiated and sh

59 ary cancer, while PAK4 gene depletion delays MMTV-PyMT driven tumors.

60 on is diminished significantly in developing MMTV-Cre;NRP2(loxP/loxP) mammary glands compared with co

61 from Dmp1(+/+);MMTV-cyclin D1 and Dmp1(+/+);MMTV-D1T286A mice but significantly down-regulated in th

62 pre-malignant mammary glands from Dmp1(+/+);MMTV-cyclin D1 and Dmp1(+/+);MMTV-D1T286A mice but signi

63 Here, we show that, contrary to dogma, MMTV-Wnt1 mammary tumors with mutant p53 exhibited a sup

64 r data support the hypothesis that efficient MMTV particle assembly is dependent upon the interaction

65 We crossed the inducible erbB2 (MMTV-iErbB2) and Wnt (MMTV-Wnt) transgenic mice to the S

66 Additionally, they examine MMTV-PyMT control or POSTN null mice to test the effect

67 In female MMTV-HER2/neu transgenic mice, we found that ERalpha and

68 Methods: Female MMTV-PyMT mice were treated with pexidartinib, a colony-

69 Ccn6(fl/fl);MMTV-Cre mice developed invasive high grade mammary carc

70 Ccn6(fl/fl);MMTV-Cre mice displayed severe defects in ductal branchi

71 signal peptidase in the ER is necessary for MMTV-SP function in a reporter assay, but many requireme

72 As predicted, TGFbeta2 was high in four MMTV-Hoxb7/Her2 transgenic mouse tumor cell lines and tw

73 F-1alpha levels and tumor cells created from MMTV-Neu mice harboring deletion of Hif1alpha alleles re

74 cer cell lines and tumor cells cultured from MMTV-PyMT mice.

75 rated using Akt1 knockout cells derived from MMTV-ErbB2 transgenic mice.

76 s established from tumor tissue derived from MMTV-Neu/Tcfap2c(L/L) control animals and parallel cell

77 atic Mvt-1 mammary cancer cells derived from MMTV-PyVmT/FVB-N transgenic mice and c-Myc/vegf tumor ex

78 two separate lineages that are distinct from MMTV.

79 Indeed, tumors isolated from MMTV-Neu mice contain elevated HIF-1alpha levels and tum

80 Conditioned media (CM) obtained from MMTV-PyMT and MMTV-Her2/Neu tumor cells cultured in vitr

81 compared mammary progenitor cell pools from MMTV-neu;Nedd9(-/-) versus MMTV-neu;Nedd9(+/+) mice.

82 h high levels of MELK in mammary tumors from MMTV-Wnt1/MELK-GFP bitransgenic mice resulted in a signi

83 Furthermore, MMTV incorporation of a weak agonist LPS from Bacteroide

84 GPNMB in the mammary epithelium to generate MMTV/GPNMB transgenic mice and crossed these animals to

85 endence upon Ras mutations we have generated MMTV regulated Myc and Myc T58A transgenic mice.

86 Histopathologically, MMTV-Espl1 tumors are highly heterogeneous showing featu

87 alysis of the Akt2/miR-21 pathway in hypoxic MMTV-PyMT-induced mouse mammary adenocarcinomas and huma

88 e distinct mouse lines carrying an identical MMTV-Cre transgene (lines A, D, and F).

89 ngle-cell transplantation assays to identify MMTV-Her2/Neu mouse mammary TICs as CD24(+):JAG1(-) at a

90 In MMTV-cNeu(Tg/Tg) mice, which model HER2/Neu-amplified br

91 In MMTV-Cre;Vangl2(flox/flox) glands, cell turnover is redu

92 In MMTV-ErbB2 transgenic mice, loss of Pak1 prolonged survi

93 reast cancer, and constitutive activation in MMTV-SmoM2 transgenic mice caused alterations in mammary

94 n tumor cell allografts in nude mice, and in MMTV-Neu transgenic mice.

95 pothesis, we used DMH1, a BMP antagonist, in MMTV.PyVmT expressing mice.

96 n vivo analysis, indicated tumors arising in MMTV-neu;Nedd9(-/-) mice had undergone mutational select

97 the casr gene in mammary epithelial cells in MMTV-PymT mice reduced tumor PTHrP expression and inhibi

98 of the already transformed mammary cells, in MMTV-Wnt1 mice.

99 f YB-1 resulted in a significant decrease in MMTV particle production, indicating that YB-1 plays a r

100 Furthermore, Lgr4 deletion in MMTV- Wnt1 tumor cells or knockdown in human breast canc

101 Prex1 deletion in MMTV-neu or MMTV-PyMT mice reduced Rac1 activation in vi

102 Here we show that Ube2o deletion in MMTV-PyVT or TRAMP mice profoundly impairs tumor initiat

103 blation impeded mammary tumor development in MMTV-Wnt1 mice, further underscoring a requirement of TG

104 22 promotes aggressive metastatic disease in MMTV-miR-22 TG mice, as well as compound MMTV-neu or -Py

105 ntraperitoneal (i.p.) delivery of SSO Ex5 in MMTV-PyMT mice redirects SmgGDS splicing in the mammary

106 MMTV-PREX1 expression in MMTV-neu mice increased tumor initiation and enhanced me

107 this difference is replicated faithfully in MMTV-PyMT and MMTV-Her2 transgenic mouse models of breas

108 Kiss1r heterozygosity in MMTV-PyMT mice was sufficient to attenuate breast cancer

109 origenesis with increased lung metastasis in MMTV-Neu mouse model of spontaneous breast cancer.

110 that only a limited effect on metastasis in MMTV-neu;Nedd9(-/-) mice compared with MMTV-neu;Nedd9(+/

111 in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-amplified tumor organoids, incre

112 e PyMT model, as no changes were observed in MMTV-c-Neu mice carrying the Apc(Min/+) mutation.

113 core, reminiscent of structures observed in MMTV-Wnt1 tumours.

114 on of HMGA2 and EZH2 proteins is observed in MMTV-Wnt10b(LacZ) transgenic mice during metastasis, and

115 significantly delays mammary tumor onset in MMTV-Wnt1 females, whereas acute deletion of Pygo2 in MM

116 sion dramatically accelerates tumor onset in MMTV/Wnt-1 mice.

117 opment of breast cancer of luminal origin in MMTV-ErbB2 mice.

118 In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the ma

119 that epithelia-specific ablation of Pygo2 in MMTV-Wnt1 transgenic mice results in delayed mammary duc

120 females, whereas acute deletion of Pygo2 in MMTV-Wnt1 tumor cells leads to a significant decrease in

121 uction, indicating that YB-1 plays a role in MMTV capsid formation.

122 eration and increased apoptosis were seen in MMTV-HER2 and MMTV-Neu mammary glands lacking ErbB3, thu

123 Loss of stathmin in MMTV-Delta16HER2 transgenic mice decreased the incidence

124 TFAP2C, we examined mammary tumorigenesis in MMTV-Neu transgenic female mice with or without conditio

125 lapatinib-treated HER2(+) mammary tumors in MMTV-Neu mice, increased immunosuppressive cytokines, my

126 C59 blocked progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/beta-

127 nts indicated that overexpression of Zpo2 in MMTV-PyMT mammary tumor cell lines enhances lung metasta

128 in four preclinical model systems, including MMTV-huHER2 and huCD3 transgenic mice.

129 O(2), NH(2), and OH analogues also inhibited MMTV-Wnt1 murine mammary stem cell viability.

130 Although wingless integrated MMTV (Wnt)/beta-catenin signaling plays an essential rol

131 mor development and metastasis, we interbred MMTV-PyMT mice with E2F1, E2F2, or E2F3 knockout mice.

132 Interestingly, MMTV-Cre, Grp78(f/f) mammary glands displayed only sligh

133 d-type bone marrow, into lethally irradiated MMTV-PyVmT mice (a model of metastatic breast cancer) de

134 High level MMTV-driven transgenic PREX1 expression resulted in apic

135 al outgrowth compared with either littermate MMTV-Cre;NRP2(+/loxP) or MMTV-Cre mice.

136 etic model for breast cancer and metastasis (MMTV-PyMT), a syngeneic melanoma lung colonization model

137 lore this possibility, the highly metastatic MMTV-PyMT mice were crossed with 25 AKXD (AKR/J x DBA/2J

138 omoter-driven HA-14-3-3zeta transgenic mice (MMTV-HA-14-3-3zeta) developed mammary tumors, whereas co

139 In mice, MMTV-PAK4 overexpression promotes spontaneous mammary ca

140 in a constitutive breast cancer mouse model (MMTV-PyMT-Tg).

141 The breast cancer mouse model, MMTV-PyMT (PyMT), developed breast tumors with lung meta

142 dels of mammary cancer: genetically modified MMTV-PyMT mice and orthotopically grafted 4T1 tumor cell

143 d mice with an inducible form of mS100a7a15 (MMTV-mS100a7a15 mice).

144 tasis, and caused tumor regression in 60% of MMTV-Neu mice.

145 restored both protein levels and activity of MMTV-SP.

146 We observed that the affinity of MMTV MA to the membrane is lower than that of HIV-1 MA,

147 rences, including lower membrane affinity of MMTV MA.

148 ne deamination by virion-packaged APOBEC3 of MMTV early reverse transcription DNA occurred only at lo

149 The association of MMTV Gag and YB-1 in cytoplasmic granules was not disrup

150 However, the association of MMTV Gag and YB-1 was RNA dependent, and an MMTV RNA rep

151 his may reflect the long-term coexistence of MMTV and APOBEC3 in mice.

152 n (KD) miR-155 in the myeloid compartment of MMTV-PyMT mice, a mouse model of spontaneous breast carc

153 ile APOBEC3-mediated cytidine deamination of MMTV may occur, it is not the major means by which APOBE

154 nding the cancer-prone mammary epithelium of MMTV-Neu mice influences tumor development.

155 ificantly in preneoplastic mammary glands of MMTV-Her2 mice which showed a putative transformed popul

156 The morphogenetic pathway of MMTV assembly is similar to that of Saccharomyces cerevi

157 Pygo2 in modulating the lineage potential of MMTV-Wnt1 tumor initiating cells.

158 is essential for the efficient production of MMTV particles, a process directed by the viral Gag prot

159 s to predict pathway activity in subtypes of MMTV-Myc mammary tumors.

160 cid signal peptide (SP) at the N terminus of MMTV Rem or envelope proteins.

161 , we used virions from the mammary tissue of MMTV-infected inbred wild-type mice with different allel

162 Candidate gene analysis on MMTV-Cre;Vangl2(flox/flox) and Vangl2(Lp/Lp) tissue reve

163 irus-driven polyoma virus middle T oncogene (MMTV-PyVT)].

164 h either littermate MMTV-Cre;NRP2(+/loxP) or MMTV-Cre mice.

165 Prex1 deletion in MMTV-neu or MMTV-PyMT mice reduced Rac1 activation in vivo and impro

166 TV)-Polyoma virus middle T antigen (PyMT) or MMTV-c-Neu transgenic mice.

167 Deletion of the Bcl3 gene in ErbB2-positive (MMTV-Neu) mice resulted in a 75% reduction in metastatic

168 In the preclinical MMTV-PyMT mouse model, integrin alpha11-deficiency led t

169 cancer [murine mammary tumor virus promoter (MMTV-NIC)].

170 lexes is facilitated by YB-1, which promotes MMTV virus assembly.

171 that the timed secretion of Wingless-related MMTV (mouse mammary tumor virus) integration site 3 (WNT

172 which secrete the morphogen Wingless-related MMTV (mouse mammary tumor virus) integration site 3 (WNT

173 Wingless-related MMTV integration site 1 (WNT1)/beta-catenin signaling pl

174 secreted modulator of WNT (Wingless-related MMTV integration site)/beta-catenin signaling, is both n

175 se mammary tumor virus long terminal repeat (MMTV-LTR).

176 ammary epithelium of our previously reported MMTV-tva transgenic mice, we detected high-grade, poorly

177 t the major means by which APOBEC3 restricts MMTV infection in vivo.

178 (MEC) populations, and oncogenic signaling, MMTV-ErbB2 transgenic mice were administered AZD4547 (2-

179 also leads to the regression of spontaneous MMTV-PyMT mammary tumors.

180 mouse mammary tumor virus-Polyoma Middle T (MMTV-PyMT) model of luminal breast cancer, induction of

181 mouse mammary tumor virus-Polyoma Middle T (MMTV-PyMT), which mimics RANK and RANKL expression patte

182 (DCIS) in a transgenic mouse model [FVB/N-Tg(MMTV-PyMT)634Mul].

183 ivated in the MMTV-expressing cells and that MMTV-induced apoptosis resistance was completely restore

184 We found that MMTV, when ingested by newborn mice, stimulates a state

185 Our data revealed that MMTV Gag colocalized with YB-1, a translational regulato

186 Our studies revealed that MMTV-Cre, Grp94(f/f) mammary glands, despite GRP94 defic

187 These data revealed that MMTV/Wnt-1 x MMTV/GPNMB bigenic tumors exhibit a pro-gro

188 Our results show that MMTV suppresses apoptosis through ITAM-mediated Src tyro

189 Here, we show that MMTV-Her2/Neu mammary tumor cells cultured as nonadheren

190 We previously showed that MMTV Env expression transformed normal mammary epithelia

191 this LPS to stimulate TLR4, suggesting that MMTV intensifies these immunostimulatory properties.

192 The MMTV-neu;Nedd9(-/-) genotype selectively reduced both th

193 Overexpression of L9 in cells expressing the MMTV(C3H) provirus resulted in specific, robust accumula

194 ctivated pathways in tumors derived from the MMTV/Wnt-1 and MMTV/Wnt-1 x MMTV/GPNMB mice using RPPA a

195 model of mammary tumorigenesis harboring the MMTV-HER2 oncogene and mutation of MED1 to evaluate its

196 ing antisense oligonucleotides (ASOs) in the MMTV (mouse mammary tumor virus)-PyMT mouse mammary carc

197 In the MMTV-Delta16HER2 transgenic mouse model, oncogene transf

198 xycycline-induced expression of FIP1C in the MMTV-ErbB2 mouse model resulted in delayed mammary tumor

199 o found that Src kinase was activated in the MMTV-expressing cells and that MMTV-induced apoptosis re

200 The early disseminating cells in the MMTV-Her2 breast cancer model are Her2(high)p-p38(low)p-

201 gh)Tpl2(low)p-p38(low)E-cadherin(low) in the MMTV-Her2 breast cancer model.

202 equences of genetic ablation of Nedd9 in the MMTV-HER2/ERBB2/neu mouse mammary tumor model.

203 However, in the MMTV-Her2/neu transgenic mouse model, the identity of TI

204 In the MMTV-neu mouse model of breast cancer and the U251 xenog

205 Thus, in the MMTV-PyMT mouse mammary model, increased ELF5 levels dri

206 mutant delays onset of mammary tumors in the MMTV-PyMT mouse model of breast cancer.

207 In the MMTV-PymT mouse model of mammary carcinoma, we found tum

208 gene-driven breast cancer progression in the MMTV-PyMT mouse model.

209 utation of phosphatases such as PTPRH in the MMTV-PyMT mouse model.

210 In the MMTV-PyMT oncomouse model of breast cancer, in which we

211 In the MMTV-PyMT transgenic mouse model of breast cancer and in

212 gh studies of CaSR-PTHrP interactions in the MMTV-PymT transgenic mouse model of breast cancer and in

213 The absence of Dek in the MMTV-Ron mouse model led to a significant delay in tumor

214 In the MMTV-Wnt1 mouse model, regression of mammary tumors by F

215 ve antagonist of Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model.

216 genesis with kinetics similar to that of the MMTV-c-src(Act) mice.

217 ective Dmp1 deletion was found in 21% of the MMTV-D1 and D1T286A mammary carcinomas, and the Dmp1 het

218 expressing human FLAG-PAD2 downstream of the MMTV-LTR promoter develop spontaneous neoplastic skin le

219 expression in the mammary epithelium of the MMTV-Neu mouse.

220 sgenic mice and crossed these animals to the MMTV/Wnt-1 mouse model, which is known to recapitulate f

221 In this study, we used the MMTV-Neu-Tg mouse mammary tumor model to identify potent

222 Using the MMTV-Polyoma Middle T antigen (PyMT) mouse model of huma

223 Using the MMTV-PyVmT/FVB mammary tumor model, we demonstrate a nov

224 When combined with the MMTV-NIC model, these in vivo experiments provided the f

225 Thus, MMTV has evolved to rely on the interaction with the mic

226 The mammary tumors arising in Tip30(-/-)/MMTV-Neu mice were exclusively ER+/PR-.

227 To investigate this, we created a traceable MMTV-Wnt1-driven in vivo chimeric mammary tumor model co

228 n in animals, we have generated a transgenic MMTV-Espl1 mouse model that overexpresses Separase prote

229 Double transgenic MMTV-Her2-miR489 mice were then generated to observe how

230 mammary tumor tissues from double-transgenic MMTV-Hoxb7/Her2 mice than tumors from single-transgenic

231 anted mammary tumors derived from transgenic MMTV-PyMT mice were scanned with (18)F-FDG PET/CT.

232 y ablated in the oncogene-induced transgenic MMTV-PymT tumor model.

233 Here, we exploit the transgenic MMTV-ErbB2 (v-erb-b2 avian erythroblastic leukemia viral

234 ide additional evidence in triple transgenic MMTV/QR/Arom mice, wherein the QR expression is induced

235 induces a normalized growth of transplanted MMTV-PyMT breast tumours cells.

236 nduced lung fibrosis model we used wild-type MMTV mice and a triple transgenic mouse SPC-rtTA(+/-)Tet

237 Fibroblast growth factor (Fgf)-Wingless type MMTV integration site family (Wnt) genetic module in the

238 the sonic hedgehog pathway and Wingless type MMTV integration site family were validated by immunohis

239 eas the roles of the canonical wingless-type MMTV (mouse mammary tumor virus) integration site family

240 d 3 main clusters of HCCs: the wingless-type MMTV integration site (32 of 89; 36%), interferon-relate

241 cued by local treatment with a Wingless-type MMTV integration site (Wnt) antagonist, Dickkopf-1 (Dkk1

242 The vital role of Wingless-type MMTV integration site (Wnt)/beta-catenin signaling in th

243 converging to dysregulate the Wingless-type MMTV integration site (Wnt)/beta-catenin signaling, a ke

244 errant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathogno

245 The wingless-type MMTV integration site family (WNT)/beta-catenin/adenomat

246 Wingless-type MMTV integration site family (WNT)16 is a key regulator

247 ntified causative mutations in wingless-type MMTV integration site family 1 (WNT1).

248 bone morphogenetic protein and wingless-type MMTV integration site family member (Wnt) superfamilies,

249 s in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT1), trimeric i

250 includes the Wnt family member wingless-type MMTV integration site family member 16B (WNT16B).

251 ted protein, which retains the Wingless-type MMTV integration site family member-ligand-binding domai

252 WNT10A (Wingless-type MMTV integration site family, member 10A) plays a crucia

253 a repressor of canonical WNT (wingless-type MMTV integration site) signaling.

254 haracteristics of the primary tumors, unlike MMTV-Wnt1 mice.

255 Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null back

256 In this study, we used MMTV-Myc-driven tumors to model breast cancer heterogene

257 r cell pools from MMTV-neu;Nedd9(-/-) versus MMTV-neu;Nedd9(+/+) mice.

258 ing of the B-type mouse mammary tumor virus (MMTV) and C-type HIV-1, which assemble in the cytoplasm

259 ol infection with mouse mammary tumor virus (MMTV) and murine leukemia virus (MuLV) via an adaptive i

260 Integration of mouse mammary tumor virus (MMTV) at the common integration site Int6 occurs in the

261 Mouse mammary tumor virus (MMTV) encodes a Rev-like protein, Rem, which is involved

262 es, including the mouse mammary tumor virus (MMTV) envelope (Env).

263 The mouse mammary tumor virus (MMTV) Gag protein directs the assembly in the cytoplasm

264 HIV in humans and mouse mammary tumor virus (MMTV) in mice.

265 Mouse mammary tumor virus (MMTV) is a complex murine retrovirus that encodes an HIV

266 er control of the mouse mammary tumor virus (MMTV) long-terminal repeat (MMT mice).

267 ffect of DEX in a mouse mammary tumor virus (MMTV) luciferase reporter transactivation assay.

268 murine retrovirus mouse mammary tumor virus (MMTV) orchestrates the assembly of immature virus partic

269 mitted retrovirus mouse mammary tumor virus (MMTV) requires the intestinal microbiota for persistence

270 e first time that mouse mammary tumor virus (MMTV), a mammalian retrovirus that assembles intracytopl

271 iruses, including mouse mammary tumor virus (MMTV), are transmitted most efficiently through mucosal

272 ovirus (JSRV) and mouse mammary tumor virus (MMTV), as well as many endogenous retroviruses.

273 eletion inhibited mouse mammary tumor virus (MMTV)- PyMT- and MMTV- Wnt1-driven mammary tumorigenesis

274 In the mouse mammary tumor virus (MMTV)-driven polyoma middle-T oncogene strain, which sho

275 Mouse mammary tumor virus (MMTV)-ErbB2 mice lacking PKCdelta (deltaKO) have increas

276 in breast cancer, mouse mammary tumor virus (MMTV)-Her2/neu transgenic mice that develop mammary tumo

277 The mouse mammary tumor virus (MMTV)-MT model of breast cancer has been important for p

278 tion of tumors in mouse mammary tumor virus (MMTV)-Neu mice.

279 in xenograft and mouse mammary tumor virus (MMTV)-neu mouse models in a manner associated with activ

280 lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model.

281 crossed with the mouse mammary tumor virus (MMTV)-Polyoma virus middle T antigen (PyMT) or MMTV-c-Ne

282 on factors in the mouse mammary tumor virus (MMTV)-polyomavirus middle T oncoprotein (PyMT) mouse mod

283 (R175H) mice and mouse mammary tumor virus (MMTV)-Wnt-1 transgenic (mWnt-1) mice to specifically add

284 mammary tumors of mouse mammary tumor virus (MMTV)-Wnt1-transgenic mice and in aggressive basal subty

285 of the unrelated mouse mammary tumour virus (MMTV).

286 heir tumor inhibition efficacy using in vivo MMTV-neu transplantation mouse model.

287 In vivo, MMTV infection delayed involution-induced apoptosis in t

288 ing factors, prompting us to examine whether MMTV utilizes a similar set of host proteins to facilita

289 However, the mechanisms by which MMTV associates with LPS remain unknown.

290 ) have increased tumor latency compared with MMTV-ErbB2 wild-type (deltaWT) mice, and the tumors show

291 y tumorigenesis and metastasis compared with MMTV-neu mice.

292 is in MMTV-neu;Nedd9(-/-) mice compared with MMTV-neu;Nedd9(+/+) mice, but instead a dramatic reducti

293 umber of CD39(+)CD73(+) TDMMCs compared with MMTV-PyMT/TGFbetaRII(WT) control tumors with intact TGF-

294 When crossed with MMTV-neu transgenic mice, 14-3-3zeta.neu transgenic mice

295 or growth, we interbred FABP5-null mice with MMTV-ErbB2/HER2 oncomice, which spontaneously develop ma

296 d the inducible erbB2 (MMTV-iErbB2) and Wnt (MMTV-Wnt) transgenic mice to the SOD1 heterozygote or kn

297 MMTV/Wnt-1 x MMTV/GPNMB bigenic mice also exhibit a significant incre

298 These data revealed that MMTV/Wnt-1 x MMTV/GPNMB bigenic tumors exhibit a pro-growth signature

299 derived from the MMTV/Wnt-1 and MMTV/Wnt-1 x MMTV/GPNMB mice using RPPA analysis.

300 susceptible mammary glands from E-R72 (R72 x MMTV-Erbb2/Neu) mice developed a senescence-associated s