ライフサイエンスコーパス: MODS

1 MODS carries a high mortality and morbidity rate and adv

2 MODS detected 94.0% of 1,908 positive sputum cultures, w

3 MODS is a novel assay which can detect the organisms res

4 MODS transcripts differentially expressed in the hyperac

5 MODS was defined as a Denver Multiple Organ Failure scor

6 MODS-Wayne had an agreement of 93.8% and a kappa index o

7 MODS-Wayne is based on the detection of pyrazinoic acid,

8 MODS-Wayne was able to detect PZA resistance, with a sen

9 d it afforded therapeutic protection against MODS in a rat model of AP.

10 nger (tempol) on the circulatory failure and MODS (kidney, liver, lung) caused by coadministration of

11 2 to fraction of inspired oxygen (FIO2), and MODS scores.

12 sociated with improvement in lung injury and MODS scores and reduced mortality.

13 evels and similar changes in lung injury and MODS scores.

14 omponents of the lung injury score (LIS) and MODS score.

15 ococcus aureus, synergize to cause shock and MODS in the rat.

16 systemic inflammatory response syndrome and MODS.

17 pathway activation in relation to AP and AP-MODS in humans, by carrying out a prospective observatio

18 he lung, kidney and liver in experimental AP-MODS.

19 Acute mortality from AP-MODS exceeds 20%, and the lifespans of those who survive

20 ies available to protect individuals from AP-MODS.

21 therapeutic strategy in the treatment of AP-MODS, and they open up a new area for drug discovery in

22 bolism, is central to the pathogenesis of AP-MODS.

23 itis multiple organ dysfunction syndrome (AP-MODS); a devastating inflammatory condition with a morta

24 KT cell numbers, to patient outcomes such as MODS warrants further investigation.

25 copic observation drug susceptibility assay (MODS), a novel assay developed in Peru which uses an inv

26 ples from 50 children with sepsis-associated MODS were categorized as meeting criteria for PHES, PMOD

27 icro g/ml), there was 100% agreement between MODS results read at day 11 and the reference method.

28 e-positive: 91 (94%) by MGIT and 74 (76%) by MODS (p = 0.002).

29 We prospectively compared MODS and Xpert MTB/RIF with standard microscopy and cult

30 In conclusion, MODS-PZA is presented as a fast, simple, and low-cost DS

31 In conclusion, MODS-Wayne is a simple, fast, accurate, and inexpensive

32 M], 262 [19] vs 148 [35]; P<.001); decreased MODS score (mean [SEM], 0.7 [0.2] vs 1.8 [0.3]; P<.001);

33 markers in patients who would later develop MODS, with down-regulation of neutrophil deconvolution m

34 between patients who did or did not develop MODS (9.8 + 4.6 mEq/L vs. 9.4 + 4.4 mEq/L), but had good

35 red with the 16 patients who did not develop MODS (NoMODS), maximal differential expression was seen

36 likely than normothermic patients to develop MODS (21% vs. 9%, P = 0.003).

37 critically injured patients later developed MODS.

38 Patients who developed MODS also had elevated mtDNA DAMP levels compared with t

39 discriminated between patients who developed MODS and those who did not, and many of these difference

40 ers of the hyperacute response and different MODS phenotypes, and requires validation in other critic

41 sive and may lead to multiorgan dysfunction (MODS).

42 protects against multiple organ dysfunction (MODS) in experimental acute pancreatitis (AP).

43 life-threatening multiple organ dysfunction (MODS).

44 osed as a potential therapeutic approach for MODS after trauma and/or hemorrhage.

45 series) and is a significant risk factor for MODS but not mortality.

46 ermia remained a significant risk factor for MODS when systolic blood pressure, volume of fluid, and

47 ectively bind those histones responsible for MODS and do not bind to serum proteins.

48 a subgroup of patients at increased risk for MODS to permit effective therapeutic intervention.

49 Here, we describe a therapeutic strategy for MODS based on the neutralization of histones by chemical

50 e recovery in pediatric sepsis patients from MODS to a mild state and thus assist the clinicians in t

51 -based approach to predict the recovery from MODS to zero or single organ dysfunction by 1 week in ad

52 All 21 evaluated study subjects had MODS.

53 as an early targeted intervention for hrTMA/MODS.

54 systemic inflammation, tissue hypoperfusion, MODS, and fatal outcome.

55 The most important MODS-related pathophysiologic conditions known to date h

56 In MODS versus NoMODS, 363 genes were differentially expres

57 The mean change in MODS was an increase of 8.5 and 8.7 points, respectively

58 ith significant differences in the change in MODS.

59 Bacterial loads, MODS, leukopenia, neutrophil infiltration, immune cell a

60 we standardized and evaluated a new method, MODS-Wayne, to determine PZA resistance.

61 MGIT, MODS and Xpert MTB/RIF on the initial specimen identifie

62 The sensitivity of MGIT, MODS and Xpert MTB/RIF was 88%, 71% and 76%, respectivel

63 worsening organ failure (increased modified MODS).

64 Chronic Health Evaluation II score, modified MODS, and prothrombin time and the lowest platelet count

65 ive value of base deficit for development of MODS is blunted in the presence of hypothermia.

66 criptomic signature for later development of MODS was present in this hyperacute window; it showed a

67 ll numbers and the subsequent development of MODS.

68 A comprehensive prospective evaluation of MODS is under way in Peru, and independent validation in

69 The most prevalent mediating factors of MODS were examined for their potential to induce apoptos

70 ndary endpoints were cumulative incidence of MODS 6 months after hrTMA diagnosis and 1-year posttrans

71 or settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

72 Contemporary management of MODS is entirely supportive, and no specific therapeutic

73 increases in the serum levels of markers of MODS normally observed in this model.

74 nes are implicated as essential mediators of MODS.

75 mers in human cells and in a murine model of MODS.

76 The pathogenesis of MODS remains unclear, and several models are proposed, s

77 o a new understanding of the pathogenesis of MODS.

78 a unifying theory for the pathophysiology of MODS.

79 Significant predictors of MODS using multivariate analysis included minimum StO2 (

80 ed to determine the effect of baricitinib on MODS.

81 nfluence of acalabrutinib or fenebrutinib on MODS.

82 ; p =.02] and in patients with > or =3-organ MODS (9.2% [5.1,16.7] vs. 15.5% [8.3, 28.6]; p =.01).

83 with survival in patients with > or =3-organ MODS (p =.01).

84 with less %FO in patients with > or =3-organ MODS.

85 rstand the effect of hypothermia on outcome (MODS and mortality).

86 P-MODS correlated strongly with pediatric intensive care u

87 P-MODS was calculated by summing the worst score for all v

88 ediatric Multiple Organ Dysfunction Score (P-MODS); c) correlation of the score with outcome at pedia

89 ion across many centers, it is likely that P-MODS could function as a quantitative, clinically releva

90 ck" (PHES) and "sepsis-associated persistent MODS" (PMODS).

91 th mortality, persistent ARDS, or persistent MODS using multivariable mixed effect models.RESULTSIn 2

92 pped with markers associated with persistent MODS, rather than persistent ARDS.FUNDINGNIH (K23HL-1366

93 s, and DAMPs were associated with persistent MODS.

94 Posttraumatic MODS, which is in part due to excessive systemic inflamm

95 A low StO2 value predicts MODS and mortality in trauma patients and is a durable m

96 18%; p < 0.01) and its components prolonged MODS (59/152 [39%] vs 43/249 [17%]), and PICU mortality

97 sistent lymphopenia are at risk of prolonged MODS or PICU mortality.

98 ociated with the composite outcome prolonged MODS or PICU mortality (66/152, 43% vs 45/249, 18%; p <

99 change in Multiple Organ Dysfunction Score (MODS; range, 0 to 24, with higher scores indicating more

100 Four patients died secondary to severe MODS.

101 Ps is associated with the evolution of SIRS, MODS, and mortality in severely injured human subjects.

102 microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis

103 microscopic observation drug susceptibility (MODS) assay, was compared to that of the reference 7H10

104 Microscopic Observation Drug Susceptibility (MODS) culture or the Xpert MTB/RIF assay might be used t

105 ystemic multiple organ dysfunction syndrome (MODS) and death.

106 cluding multiple organ dysfunction syndrome (MODS) and death.

107 ment in multiple organ dysfunction syndrome (MODS) and development of nosocomial infections.

108 to the multiple organ dysfunction syndrome (MODS) caused by endotoxin.

109 ment of multiple organ dysfunction syndrome (MODS) following infection or tissue injury is associated

110 nent of multiple organ dysfunction syndrome (MODS) following pulmonary infection.

111 on the multiple organ dysfunction syndrome (MODS) in a rat model of hemorrhagic shock (HS) and (b) w

112 reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-term follow-up) hemo

113 reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-term follow-up) hemo

114 ts, the multiple organ dysfunction syndrome (MODS) is considered a significant risk factor for advers

115 odified Multiple Organ Dysfunction Syndrome (MODS) score (which did not score for thrombocytopenia).

116 score), multiple organ dysfunction syndrome (MODS) score, admission status, days without nutrition, U

117 ates in multiple organ dysfunction syndrome (MODS) that is normally triggered by gut ischemia-reperfu

118 Multiple organ dysfunction syndrome (MODS) was present in 103 patients; 59 survived (57%).

119 ressive multiple organ dysfunction syndrome (MODS), and an unfavorable outcome.

120 sepsis, multiple organ dysfunction syndrome (MODS), and death.

121 e syndrome, multiorgan dysfunction syndrome (MODS), and death.

122 (SIRS), multiple organ dysfunction syndrome (MODS), and mortality.

123 sequent multiple organ dysfunction syndrome (MODS), associated with trauma in a rat model of hemorrha

124 ed with multiple organ dysfunction syndrome (MODS), which may involve the gastrointestinal tract.

125 in the multiple organ dysfunction syndrome (MODS), with or without accompanying sepsis.

126 of the multiple organ dysfunction syndrome (MODS).

127 mes due to multi-organ dysfunction syndrome (MODS).

128 cluding Multiple Organ Dysfunction Syndrome (MODS).

129 ment of multiple organ dysfunction syndrome (MODS).

130 sistent multiple organ dysfunction syndrome (MODS).METHODSIn a single-center prospective cohort of in

131 olonged multiple organ dysfunction syndrome (MODS, organ dysfunction beyond day 7) or PICU mortality.

132 id and rifampin drug susceptibility testing, MODS is as accurate as and more rapid than the reference

133 The MODS caused by an excessive systemic inflammatory respon

134 Human HDLs attenuate the MODS associated with ischemia and reperfusion injury aft

135 , and low-cost DST that could complement the MODS assay to evaluate resistance to the principal first

136 , may be repurposed for the treatment of the MODS after trauma and/or hemorrhage.

137 Here, for the first time, MODS culture at neutral pH was evaluated using high PZA

138 om the primary injury site may contribute to MODS.

139 2 had a greater incidence of progression to MODS as defined by the Marshall MOD score, a longer dura

140 ained by direct susceptibility testing using MODS demonstrated excellent concordance for isoniazid an

141 diverse clinical conditions associated with MODS.

142 as not affected the outcome of patients with MODS.