ライフサイエンスコーパス: MSG

1 MSG consumption was positively, longitudinally associate

2 MSG contents ranged from 0.01g/100g to 15.39g/100g in fo

3 MSG is encoded by a multicopy gene family; in two specif

4 MSG treatments induced hypogonadism and obesity, retain-

5 MSG- and vehicle-treated hamsters given an exogenous nor

6 MSG-evoked neuronal activation in the nTS was measured b

7 MSG-treated hamsters exhibited normal entrainment to the

8 MSG/IMP+ conditions significantly reduced subsequent int

9 MSGs from pSS patients contain IL-17-expressing cells as

10 Conclusion: Orally administered MSG significantly decreased salivary gland, kidney, and

11 As adults, MSG-treated hamsters had significantly increased body ma

12 ed maximally during the initial 20 min after MSG administration.

13 ower blood pool SUL(mean) was observed after MSG administration (decrease of 11% +/- 13%, P = 0.021).

14 ower blood pool SUL(mean) was observed after MSG administration (decrease of 11% 13%, P = 0.021).

15 ody mass (SUL(max)) on images obtained after MSG administration in the parotids (24% +/- 14%, P = 0.0

16 ody mass (SUL(max)) on images obtained after MSG administration in the parotids (24% 14%, P = 0.001),

17 n malignant lesions on scans performed after MSG administration than on the placebo studies (SUL(max)

18 e to detect the compound stimulus across all MSG (+amiloride) concentrations due, in part, to the tas

19 ch is present at the beginning of nearly all MSG mRNAs, and which is likely to be involved in regulat

20 ells infected with a baculovirus carrying an MSG gene lacking the UCS expressed a nonglycosylated 130

21 UCS peptide was ligated to the 5' end of an MSG gene and incorporated into a recombinant baculovirus

22 ssary and sufficient for transcription of an MSG gene.

23 ocus is required for the transcription of an MSG gene.

24 PET/CT scans within 14 d under baseline and MSG conditions.

25 ER, Golgi, and MSG steady-state pH values were also dependent upon the

26 at least three gene families (PRT1, MSR, and MSG) have the potential to generate high-frequency antig

27 Both the UCS and MSG genes were shown to be located at the ends of chromo

28 Golgi and MSGs required active H(+) v-ATPases for acidification.

29 MSGs, and proper acidification of Golgi and MSGs required gradual decreases in P(H+) and successive

30 2 from the trans-Golgi network into ISGs and MSGs, however, is not affected.

31 orm 1 showed strong reactivity with the anti-MSG MAb RA-C11.

32 Given that few if any MSG mRNAs lack the UCS, the correspondence between the U

33 examine the longitudinal association between MSG consumption and incidence of overweight.

34 gnificant associations were detected between MSG-localized HDAg and liver enzymes or an evident HBV c

35 there was no significant difference between MSG-obesity group and lyophilized monocomponent probioti

36 the ATP-dependent reactivation rate of bound MSG by preventing multiple cycles of its GroEL binding a

37 mal entrainment to the light-dark cycle, but MSG treatretain-->ment counteracted the circadian arrhyt

38 ies have shown that the sensation aroused by MSG is distinct from that of the other 4 taste qualities

39 T thermogenesis that could be compromised by MSG treatment.

40 Cold-exposed (18 h at 5 degrees C) MSG- and vehicle-treated hamsters initially maintained T

41 inii expresses a surface glycoprotein called MSG.

42 he major surface glycoprotein of P. carinii (MSG).

43 th a monoclonal antibody against a conserved MSG epitope.

44 (UCS), which is in frame with the contiguous MSG sequence.

45 P-A bound to purified rat P. carinii-derived MSG in a saturable and calcium-dependent manner, which w

46 no acid sequences of variants of rat-derived MSG.

47 tect IMP alone, yet some were able to detect MSG + amiloride + IMP, but only at the higher MSG concen

48 Messenger RNAs encoding different MSG isoforms start with the same sequence, called the up

49 m by which the UCS becomes part of different MSG mRNAs is not obvious because at least 15 loci, which

50 copy per haploid genome, but that different MSG genes were linked to the unique UCS locus in differe

51 Messenger RNAs encoding different MSGs each begin with the same 365-bp sequence, called th

52 e, whereas multiple copies of the downstream MSG gene were present.

53 re distributed throughout the genome, encode MSGs.

54 EORTC-MSG and FUNDICU IPA classification systems are useful fo

55 eatment-of-Cancer/Mycosis-Study Group (EORTC-MSG), Invasive-Fungal-Diseases-in-Adult-Patients-in-Inte

56 Among 202 patients, 78 had EORTC-MSG host factors and were classified accordingly, with E

57 The remaining 12 patients lacked EORTC-MSG host factors and were not in the ICU, highlighting a

58 and were classified accordingly, with EORTC-MSG criteria achieving 100% agreement in identifying cli

59 In 112 ICU patients without EORTC-MSG host factors, overall agreement was 53% for FUNDICU,

60 of these 3 assays while using the 2019 EORTC/MSG definitions (study number S59863/S61797, NCT03004092

61 en or probable invasive candidiasis by EORTC/MSG criteria in patients who did not have disease at bas

62 024; 95% CI, 1.006-1.042; P = .009) by EORTC/MSG criteria, with response rates of 83% and 28% when bo

63 IFIs were defined by EORTC/MSG criteria.

64 sible invasive mold disease defined by EORTC/MSG criteria.

65 oup Education and Research Consortium (EORTC/MSG) criteria, 30.7% (23/75), 25.3% (19/75), and 38.7% (

66 te of Allergy and Infectious Diseases (EORTC/MSG) criteria.

67 fectious Diseases Mycoses Study Group (EORTC/MSG) consensus definitions (11 probable cases and 36 con

68 fectious Diseases Mycoses Study Group (EORTC/MSG) consensus definitions (19 proven/probable cases and

69 eatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria.

70 erative Group and Mycoses Study Group (EORTC/MSG) criteria.

71 e Fungal Infections Cooperative Group (EORTC/MSG) definition.

72 fectious Diseases Mycoses Study Group (EORTC/MSG) definitions for fungal disease, commercially manufa

73 eatment of Cancer/Mycoses Study Group (EORTC/MSG) definitions of invasive fungal disease because of l

74 fectious Diseases Mycoses Study Group (EORTC/MSG) definitions, and 6-week survival.

75 fectious Diseases Mycoses Study Group (EORTC/MSG)-defined hematological population.

76 IFI (modified EORTC/MSG criteria) occurring after > 5 days of continuous azo

77 by LFD and qPCR to classify cases, the EORTC/MSG criteria had a sensitivity of 83.3%.

78 The diagnostic performance of the EORTC/MSG criteria was evaluated against the test(s) identifie

79 According to the EORTC/MSG criteria, IFD was classified as possible in 182 (34.

80 Using the EORTC/MSG criteria, the sensitivities of qPCR and LFD were 100

81 able, possible, and no IA based on the EORTC/MSG definitions.

82 now mature enough for inclusion in the EORTC/MSG definitions.

83 GM in BAL had modest agreement with EORTC/MSG criteria for diagnosing IFD in immunocompromised pat

84 Every MSG mRNA begins with 380 nucleotides copied from the UCS

85 derivatization of naturally non-fluorescent MSG to form a fluorescent structure when reacting with o

86 nt major surface glycoprotein (MSG) fragment MSG-14, a P. jiroveci-specific protein that includes a h

87 hat are closely related to but distinct from MSG.

88 The results from MSG and placebo scans were compared by paired analysis o

89 Furthermore, MSG-evoked Fos-LI was significantly less in P2X-dblKO mi

90 The optimum DH (22.73%), EUC (6.61 g MSG/100 g protein), and EY (76.34%) of umami extract wer

91 kDa slow folding protein, malate synthase G (MSG), was investigated.

92 ta)-[(13)CHD(2)]}-labeled Malate Synthase G (MSG)--an 82-kDa monomeric enzyme that contains 73 Ala(be

93 Twelve metastasis suppressor genes (MSGs) have been identified that reduce the metastatic pr

94 Although >30 metastasis suppressor genes (MSGs) that negatively regulate metastasis have been iden

95 plants using multiplexed shotgun genotyping (MSG), and located MSG markers to the genome sequence.

96 s been detected in the minor salivary gland (MSG) tissue of Sjogren's disease (SjD) patients in the a

97 Plasma and minor salivary glands (MSGs) from patients with pSS were therefore evaluated fo

98 strain consume more monosodium l-glutamate (MSG) than do mice from the 129P3/J (129) strain.

99 ted with a solution of monosodium glutamate (MSG) (4 mg/g) subcutaneously (s.c.) at 2nd,4th, 6th, 8th

100 Neonatal monosodium glutamate (MSG) administration increases adiposity, decreases energ

101 mic or oral ad libitum monosodium glutamate (MSG) administration on glutamate levels in plasma, and o

102 etermine the impact of monosodium glutamate (MSG) administration on PSMA-radioligand biodistribution

103 ed orally administered monosodium glutamate (MSG) as a potential means of reducing kidney and salivar

104 Monosodium glutamate (MSG) has been shown to increase satiety when combined wi

105 udy on the analysis of monosodium glutamate (MSG) in broths by the induced fluorescence derivatizatio

106 the aim of quantifying monosodium glutamate (MSG) in foodstuffs, such as chips, taste cubes, sauces a

107 vor paired with 150 mm monosodium glutamate (MSG) over a flavor paired with water.

108 reated neonatally with monosodium glutamate (MSG) that destroys ARC neurons were subjected in adultho

109 eurons or via neonatal monosodium glutamate (MSG) treatment.

110 r for the detection of monosodium glutamate (MSG) using a glassy carbon electrode modified with gold

111 been hypothesized that monosodium glutamate (MSG), a flavor enhancer, is positively associated with w

112 newborn male rats with monosodium glutamate (MSG), a total growth hormone (GH) blocker, and, using cu

113 e well-known compound, monosodium glutamate (MSG), however, it was reported at a subthreshold concent

114 ha-gustducin in umami [monosodium glutamate (MSG), monopotassium glutamate (MPG), and inosine monopho

115 ts, II-VII - rats with monosodium glutamate (MSG)-induced NAFLD.

116 ephalum crepidiodes on monosodium glutamate (MSG)-induced uterine leiomyoma in albino rats and propos

117 proved the contents of monosodium glutamate (MSG)-like amino acids in mushrooms.

118 sible for the taste of monosodium glutamate (MSG).

119 orm of the sodium salt monosodium glutamate (MSG)] and the nucleotide monophosphates 5'-inosinate and

120 nces specific to major surface glycoprotein (MSG) and dihydrofolate reductase (DHFR) were used to det

121 with recombinant major surface glycoprotein (MSG) fragment MSG-14, a P. jiroveci-specific protein tha

122 The major surface glycoprotein (MSG) is an abundant, immunodominant protein on the surfa

123 d to express the major surface glycoprotein (MSG) of human P. carinii, an important protein in host-p

124 The major surface glycoprotein (MSG) of P. carinii f. sp. carinii is a family of protein

125 The major surface glycoprotein (MSG) of Pneumocystis carinii f. sp. carinii is a family

126 The major surface glycoprotein (MSG) of Pneumocystis carinii, a pathogen responsible for

127 response to the major surface glycoprotein (MSG) of Pneumocystis carinii.

128 enes encodes the major surface glycoprotein (MSG) of Pneumocystis carinii.

129 antigen known as major surface glycoprotein (MSG), which is encoded by about 100 heterogeneous genes.

130 isoforms of the major surface glycoprotein (MSG).

131 nii, namely the major surface glycoproteins (MSGs) and HSP70 proteins; three of these putative famili

132 = 6.2 +/- 0.4) to mature secretory granules (MSGs) (pH(MSG) = 5.5 +/- 0.4).

133 o ISGs and not to mature secretory granules (MSGs), and Syt IV binds to syntaxin 6, a SNARE protein t

134 Gs) gives rise to mature secretory granules (MSGs), the storage compartment in endocrine and neuroend

135 cause GroES bound to the trans side of GroEL-MSG complex, it may be anticipated that confinement of t

136 nt addition of ATP or GroES/ATP to the GroEL-MSG complex led to the formation of the native state via

137 according to EORTC and Mycoses Study Group (MSG) definitions.

138 ntations of the 1,421 magnetic space groups (MSGs), which we have made freely accessible through tool

139 ced by the DPS protocol: only 6% of retain-->MSG-treated hamsters exhibited circadian arrhythmia, whe

140 SG + amiloride + IMP, but only at the higher MSG concentrations.

141 However, MSG caused a corresponding reduction in tumor uptake, wh

142 Rats with NAFLD were untreated (group II, MSG-obesity group) and treated with probiotics (groups I

143 In MSG-treated hamsters that retained circadian rhythmicity

144 HDAg was detected in MSG acinar, ductal, myoepithelial, and adipose cells and

145 differences between B6 mice and 129 mice in MSG consumption are unrelated to strain variation in con

146 Diet, including MSG and other condiments, was assessed with a weighed fo

147 identified non-metastatic 2 (NME2) as a key MSG from a pool of >30 metastasis suppressors.

148 Monosodium L-glutamate (L-MSG), a natural component of many foods, is an important

149 Like MSG, they are cysteine-rich.

150 ern blotting studies demonstrated that, like MSG, v1MSG and v2MSG are the products of multicopy gene

151 plexed shotgun genotyping (MSG), and located MSG markers to the genome sequence.

152 a; however, it did not react with the mature MSG protein, which migrates at 116 kDa.

153 he role of taste responsiveness, we measured MSG-evoked activity in gustatory nerves and showed that

154 hat induce GFP expression only in meristems, MSG (meristem-specific GFP), were used to monitor GFP mo

155 dium glutamate and inosine 5'-monophosphate (MSG/IMP) provided either alone or in a high-energy, high

156 dium glutamate and inosine 5'-monophosphate (MSG/IMP+) or without added monosodium glutamate and inos

157 dium glutamate and inosine 5'-monophosphate (MSG/IMP-) were consumed on 4 nonconsecutive days, and ch

158 The three-gene repeat PRT1-MSR-MSG was common, suggesting that duplications of these re

159 carinii pneumonia demonstrated that multiple MSG genes were expressed in a given host, and that diffe

160 ve fibers/cells were not altered by neonatal MSG treatment despite substantial Arc and PVH destructio

161 Lastly, neonatal MSG treatment had no adverse effect on postnatal and adu

162 Therefore, we tested the effects of neonatal MSG or vehicle administration in Siberian hamsters and,

163 rast, in more posterior, viscerosensory nTS, MSG-induced Fos-LI was similar in WT and P2X-dblKO mice.

164 (IBAT) in the cold is not due to any obvious MSG-induced deletions of central sympathetic outflow cir

165 The addition of MSG/IMP to a low-energy preload had a biphasic effect on

166 d that, after intragastric administration of MSG, the MSG is preferentially metabolized through gluco

167 ined; therefore, the clinical application of MSG is unlikely to be useful in the framework of RLT.

168 ral ingestion but not topical application of MSG reduced (68)Ga-PSMA-11 uptake in salivary glands.

169 dies that show the synergy of the binding of MSG and 5'-guanylate to tongue taste tissue mirror this

170 In the case of MSG, these applications include the measurement of (1)H-

171 n the change in current and concentration of MSG.

172 most likely to modulate the conformation of MSG intermediates that can fold faster and thereby elimi

173 xplain why ad libitum dietary consumption of MSG apparently lacks neurotoxic potential.

174 ive cues and that postingestive detection of MSG does not rely on the same purinergic signaling that

175 ed impaired, if not eliminated, detection of MSG in WT and T1R1, T1R2, T1R3, and T1R2 + T1R3 KO mice

176 e for sensitive electrochemical detection of MSG.

177 elop a mathematical model of the dynamics of MSG inactivation and calculate the expected number of me

178 the attachment of the UCS to the 5' ends of MSG mRNAs.

179 onfirmed AMP and UMP were umami enhancers of MSG and contributed approximately 81% of the perceived u

180 Expression of MSG genes is not well understood.

181 s been implicated in selective expression of MSG genes.

182 ype, and second, which molecular function of MSG controls metastasis.

183 fter oral administration of either 12.7 g of MSG or placebo.

184 Thus, the inability of MSG-treated animals to sustain T(IBAT) in the cold is no

185 ndition also reduced intake independently of MSG/IMP.

186 oEL bound to the burst phase intermediate of MSG and accelerated the slowest kinetic phase associated

187 Introduction of MSG during the neonatal period leads to the NAFLD develo

188 Different isoforms of MSG are encoded by a gene family spread over at least 15

189 ding experiments, consumption of 2.3 g/kg of MSG by previously-trained rats during an 1-h period incr

190 ual organisms transcribe a limited number of MSG genes.

191 a given host, and that different patterns of MSG expression were seen among different patients.

192 samples reacted with the carboxyl portion of MSG-14; by ELISA, immunocompromised patients with Pneumo

193 h excess monosaccharides, or pretreatment of MSG with N-glycanase.

194 ocus, called UCS, supports the production of MSG mRNA.

195 ully for the detection and quantification of MSG in a wide variety of foodstuffs.

196 The quantity of MSG contained in the kg of broth was determined, with va

197 for participants in the highest quintile of MSG intake compared with those in the lowest quintile af

198 rms of rat-derived P. carinii, regulation of MSG expression uses a single expression site, termed the

199 ch is likely to be involved in regulation of MSG gene transcription.

200 P. carinii can express a broad repertoire of MSG variants.

201 howed that each contained a different set of MSG genes linked to the UCS, suggesting that UCS-MSG jun

202 o IMP but was involved in the umami taste of MSG and MPG.

203 the known higher sensitivity to the taste of MSG in juvenile rodents.

204 eptor responsible, in part, for the taste of MSG.

205 regulation of vMSG is different from that of MSG.

206 tional role of the UCS in the trafficking of MSG, the nucleotide sequence encoding the UCS peptide wa

207 To determine if translation of MSG mRNAs begins in the UCS, polyclonal antiserum was ra

208 imals showed that at least three variants of MSG were expressed in an individual lobe, that there was

209 era revealed that at least three variants of MSG were present in organisms isolated from an individua

210 SNARE molecules mediating the exocytosis of MSGs in neuroendocrine cells, syntaxin 1, SNAP-25, and V

211 ant adverse events occurred after placebo or MSG administration, and vital signs were stable.

212 0.4) to mature secretory granules (MSGs) (pH(MSG) = 5.5 +/- 0.4).

213 ential was small and not a determinant of pH(MSG).

214 However, neither steady-state pH(MSG) nor rates of passive H(+) leak were affected by Cl(

215 anslation begins in the UCS to produce a pre-MSG protein, which is subsequently directed to the endop

216 and supporting cytokines within diseased pSS MSGs without a compensatory increase in immunomodulatory

217 United States found that the flavor of pure MSG was difficult to describe.

218 The predicted proteins, like rat MSGs, were closely related but unique variants, with a h

219 t 380 nucleotides of P. carinii f. sp. ratti MSG mRNAs were 59% identical to the P. carinii f. sp. ca

220 This recombinant MSG fragment, which is the first human P. carinii antige

221 Thus, human-derived P. carinii regulates MSG expression in a manner similar to P. carinii f. sp.

222 The cumulative mean (+/-SD) MSG intake of 2.2 +/- 1.6 g/d was positively associated

223 Seven MSG genes were cloned from a single isolate by PCR or ge

224 of MPR, VAMP4, and syntaxin 6 in mature SGs (MSGs), suggesting that CCV budding from ISGs is inhibite

225 ced P. carinii populations in which a single MSG sequence resided at the UCS locus in 80 to 90% of th

226 tudy characterized HDV in a cohort of 48 SjD MSG samples collected between 2014 and 2021.

227 Systemic MSG administration (0.25, 0.5, 1 or 2 g/kg, i.p.) to adu

228 sed during the initial 20 min after systemic MSG administration, and peaked during the second 20-min

229 MP+ carbohydrate and protein conditions than MSG/IMP- condition.

230 ally, behavioral studies have indicated that MSG and L-2-amino-4-phosphonobutyrate (L-AP4), a ligand

231 ee solutions or valinomycin, indicating that MSG membrane potential was small and not a determinant o

232 Although the MSG-treated group and the C. crepidiodes-treated group h

233 PCR result and hybridization signal for the MSG gene were used for the RT-PCR experiments.

234 from hypox rats, the cells derived from the MSG-treated rats were completely unresponsive.

235 detected HDV genomic RNA localization in the MSG nuclei.

236 Energy compensation was greater in the MSG/IMP+ carbohydrate and protein conditions than MSG/IM

237 vels of luteinizing hormone (LH) levels, the MSG-induced uterine leiomyoma rats also had noticeably h

238 fter intragastric administration of MSG, the MSG is preferentially metabolized through gluconeogenesi

239 In the current study, the UCS of the MSG from human-derived P. carinii was obtained using an

240 at includes a highly conserved region of the MSG protein family.

241 ed with the complete unresponsiveness of the MSG-derived hepatocytes, also associated with hypermethy

242 The addition of the MSG/IMP+ also increased the soup pleasantness and caused

243 ntly reduced subsequent intake more than the MSG/IMP- condition did irrespective of energy.

244 igh degrees of diversity with respect to the MSG genes attached to the UCS locus.

245 ased on average from the control scan to the MSG scan by 45% 15% (P = 0.004) and 53% 11% (P < 0.001),

246 testosterone and oestradiol relative to the MSG-induced fibrotic group demonstrated that C. crepidio

247 atosis score respectively as compared to the MSG-obesity group (2.3 +/- 0.21 %).

248 probiotic mixtures (VI, VII) compared to the MSG-obesity group.

249 extend Topological Quantum Chemistry to the MSGs to form a complete, real-space theory of band topol

250 ng of SP-A to mannose-Sepharose beads and to MSG.

251 ding of SP-A to oligosaccharides attached to MSG.

252 aculovirus vectors and tested for binding to MSG.

253 re evident from our finding that exposure to MSG increases its consumption in B6 mice and decreases i

254 and v2MSG proteins are highly homologous to MSG at the carboxyl, but not the amino, terminus.

255 The similarity of its properties to MSG taste suggests that this receptor is a taste recepto

256 nt increase in the proliferative response to MSG and in interleukin-4 secretion.

257 hat interferon-gamma secreted in response to MSG was also significantly less.

258 monia showed a predominately Th2 response to MSG.

259 ignificantly less proliferative responses to MSG than did healthy controls.

260 decreased progressively from ER to Golgi to MSGs, and proper acidification of Golgi and MSGs require

261 sorted away during the maturation of ISGs to MSGs.

262 eters of URs appeared normal, but in the two MSG-treated hamsters that became circadian arrhythmic af

263 somes, suggesting that the mechanism for UCS-MSG recombination is reciprocal exchange.

264 genes linked to the UCS, suggesting that UCS-MSG junctions are formed by recombination during populat

265 Insect cells infected with the UCS-MSG hybrid gene expressed a 160-kDa protein which was N-

266 To distinguish between these two models, UCS/MSG junctions in the genome were compared with UCS/MSG j

267 The UCS/MSG junctions in the mRNA matched those in the genome, a

268 the UCS, the correspondence between the UCS/MSG junctions in transcripts and those in the genome ind

269 nctions in the genome were compared with UCS/MSG junctions in mRNA.

270 However, unlike MSG, each vMSG gene encodes a signal peptide, suggesting

271 e current study identified two novel variant MSG (vMSG) gene families in rat P. carinii that are clos

272 observed in some T1R1 and T1R3 KO mice when MSG + amiloride + IMP was tested suggests that a T1R1 or

273 o issues are poorly understood: first, which MSGs oppose metastasis in a tumor type, and second, whic

274 PCR analysis with MSG primers with tissues obtained from both groups of ra

275 Compared with MSG, v1MSG is characterized by a deletion near the carbo

276 fter the LC fractions were re-evaluated with MSG.

277 terleukin-4 levels following incubation with MSG between any of the groups; however, all the HIV-infe

278 e 5'-monophosphate acts synergistically with MSG when tasted, is present in high-protein sources, and