ライフサイエンスコーパス: MT1-MMP

1 ng membrane type I matrix metalloproteinase (MT1-MMP).

2 by membrane type 1-matrix metalloproteinase (MT1-MMP).

3 anterograde translocation and exocytosis of MT1-MMP.

4 M. tuberculosis-infected monocytes expressed MT1-MMP.

5 ctivity by recycling matrix metalloprotease, MT1-MMP.

6 proteolytic activity after targeting toward MT1-MMP.

7 27 and retromer could directly interact with MT1-MMP.

8 c cytoskeletal scaffold protein palladin and MT1-MMP.

9 oiety and proteolytic activity ligand toward MT1-MMP.

10 ction or the general proteolytic activity of MT1-MMP.

11 up-regulation of vimentin, fibronectin, and MT1-MMP.

12 small molecules targeting the PEX domain of MT1-MMP.

13 traction, which appears to be independent of MT1-MMP.

14 A sites that requires the targeted action of MT1-MMP.

15 localizes to invadopodia and interacts with MT1-MMP.

16 g of extracellular vesicles (EVs) containing MT1-MMP.

17 OP, a loop region in the catalytic domain of MT1-MMP ((163)PYAYIREG(170)), as an essential region for

18 iac Mphis increased the expression of Mmp14 (MT1-MMP) 7 days post-MI.

19 nsible of Notch1 cleavage, here we show that MT1-MMP, a membrane-tethered matrix metalloproteinase in

20 MT1-MMP were engineered to express wild-type MT1-MMP, a phosphomimetic mutant (T567E), or a phosphode

21 ns-membrane type 1 matrix metalloproteinase (MT1-MMP) accumulates.

22 Mechanistically, we showed that MT1-MMP activates latent TGFbeta1 in Mphis, leading to p

23 However, the mechanisms of collagen-mediated MT1-MMP activation and its physiological relevance are n

24 Furthermore, DDR2-dependent MT1-MMP activation by cartilage was found to be more eff

25 formed mesenchymal cells as collagen-induced MT1-MMP activation in HT1080 fibrosarcoma cells and MT1-

26 ated by peroxynitrite and involves c-src and MT1-MMP activation.

27 Neutralization of MT1-MMP activity decreased this M. tuberculosis network-

28 us membrane type 1 matrix metalloproteinase (MT1-MMP) activity does not fully inhibit cell invasion.

29 s and activates several proteases, including MT1-MMP, ADAM10, and ADAM17.

30 by membrane type-1 matrix metalloproteinase (MT1-MMP), ADAMs (a disintegrin domain and metalloprotein

31 eolytic activity of multiple MMPs instead of MT1-MMP alone.

32 Up-regulated MT1-MMP also codistributed with intracellular EphA2 in i

33 of membrane type-1 matrix metalloproteinase (MT1-MMP) anchored on invasive cancer cells and its prote

34 furin expression increases the activities of MT1-MMP and ADAM10 but not that of ADAM17, as demonstrat

35 ort a co-up-regulation and colocalization of MT1-MMP and atypical protein kinase C iota (aPKCiota) in

36 3-shRNA expression depletes shed vesicles of MT1-MMP and decreases cell invasiveness when embedded in

37 a regulator of Stx4-mediated trafficking of MT1-MMP and EGFR, advancing our understanding of the rol

38 The associations between the expression of MT1-MMP and EMT-associated proteins with clinicopatholog

39 ncreased gene and protein levels of MMP2 and MT1-MMP and induced matrix contraction in FHL-124 cells.

40 ormation is based on the cytoplasmic tail of MT1-MMP and its ability to bind the subcortical actin cy

41 gulation of the plasma membrane targeting of MT1-MMP and its associated invadopodia.

42 SRC and by coordinating ECM degradation via MT1-MMP and MMP2 expression.

43 This ensures focal delivery of MT1-MMP and supports pericellular matrix degradation and

44 amed T1(Pr alphaTACE), that colocalizes with MT1-MMP and TACE on the cell surface.

45 a designer TIMP-1 with superb affinities for MT1-MMP and TACE, to the glycosyl-phosphatidyl inositol

46 will contribute to the laboratory studies of MT1-MMP and then, ultimately, to the design of novel, mo

47 dipitously more effective against MMP-8 than MT1-MMP and was utilized successfully in a mouse model o

48 of membrane type 1 matrix metalloproteinase (MT1-MMP) and EGF receptor (EGFR) to the cell surface dur

49 se membrane-type 1 matrix metalloproteinase (MT1-MMP) and membrane-mimicking environments interplay i

50 ne-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cel

51 Membrane type 1-matrix metalloproteinase (MT1-MMP) and tumor necrosis factor alpha (TNF-alpha)-con

52 es membrane-type 1 matrix metalloproteinase (MT1-MMP)- and ERK1/2-dependent scattering of pancreatic

53 In addition, we find that ARF6, MT1-MMP, and kinesin-1 are up-regulated in high-grade tr

54 gos (membrane-type 1 matrix metalloprotease [MT1-MMP] and beta3 integrin) required for invadosome for

55 This study identifies MT1-MMP as a key MMP responsible for effecting postinfar

56 adverse remodeling post-MI and identify Mphi MT1-MMP as a key regulator of this process.

57 Here, we identify MT1-MMP as a novel interacting partner of dual-specifici

58 tumor-overexpressed matrix metalloproteinase MT1-MMP as a target.

59 ed membrane type 1-matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown.

60 e accumulation of the MMP16 substrate MMP14 (MT1-MMP) as well as L1CAM cell adhesion molecule, identi

61 ading to the decreased surface expression of MT1-MMP, as observed previously in transformed fibroblas

62 -MMP, we identify the membrane-anchored MMP, MT1-MMP, as the dominant collagenase that is operative w

63 activation of pro-MMP-2 and up-regulation of MT1-MMP at the gene and protein levels.

64 ted by phospholipase D2 drives deposition of MT1-MMP at the site of invadopodia formation and is crit

65 TIMP-2 by alpha1(IV)NC1 led to saturation of MT1-MMP binding sites, which in turn led to inhibition o

66 MT1-MMP-blocking antibodies diminished migration, prolif

67 not due to loss of the catalytic function of MT1-MMP but due to inefficient localization of the enzym

68 matrix degradation via selectively recycling MT1-MMP but not MT2-MMP.

69 osteosarcoma display a strong expression of MT1-MMP, but the role of MT1-MMP in osteosarcoma progres

70 f tyrosine Y573 in the cytoplasmic domain of MT1-MMP by LIMK.

71 mbrane type-1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeric G proteins, and in turn, the

72 Using this antibody, we have shown that the MT1-MMP-catalyzed activation of proMMP-2 is involved in

73 oxia regulates the function of DCs via KIF2A/MT1-MMP/CD44 axis, providing critical information to und

74 its L622D mutant with the single inactivated MT1-MMP cleavage site differentially regulate cell motil

75 , its Chuzhoi mutant with the two functional MT1-MMP cleavage sites, and its L622D mutant with the si

76 he membrane type-1 matrix metalloproteinase (MT1-MMP) cleavage of the PKP(621) downward arrowLI site

77 interaction in same cell-surface complexes, MT1-MMP cleaved EphA2 at its Fibronectin type-III domain

78 evidence that aPKCiota, in association with MT1-MMP-containing endosomes, phosphorylates cortactin,

79 syndrome protein and Scar homolog (WASH) on MT1-MMP-containing late endosomes in invasive breast car

80 catalytic function of the metalloproteinase MT1-MMP controls ECM structure, cell shape, and an integ

81 al. describe an unexpected function for the MT1-MMP cytoplasmic domain in imprinting spatial memory

82 To investigate the potential role of MT1-MMP cytoplasmic residue Thr(567) phosphorylation in

83 Here, we provide mechanistic insight into MT1-MMP cytoplasmic tail binding protein 1 (MTCBP-1) wit

84 nslational regulation of the Thr(567) in the MT1-MMP cytoplasmic tail may function as a regulatory me

85 e basis of a yeast two-hybrid screen for the MT1-MMP cytoplasmic tail-binding proteins, we identify h

86 mors and lung metastases, but, surprisingly, MT1-MMP deficiency did not affect primary tumor growth,

87 at membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the n

88 cally to the glomerular layer was reduced in MT1-MMP-deficient mice in contrast to controls while num

89 rge parts of the RMS were fully preserved in MT1-MMP-deficient mice, but we detected an increase in c

90 MT1-MMP delivery to nascent microvesicles depends on the

91 esin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identif

92 In contrast to MT1-MMP, DeltaPEX did not support tumor growth in vivo,

93 by membrane type-1 matrix metalloproteinase (MT1-MMP)-dependent invadopodia activity.

94 ves membrane type 1 matrix metallopatrinase (MT1-MMP)-dependent proteolysis as well as Pak, Raf, and

95 age mechanism of MT1-MMP on Notch1, and that MT1-MMP-dependent activation of Notch1 sustains melanoma

96 ng integrins, inhibited the collagen-induced MT1-MMP-dependent activation of pro-MMP-2 and up-regulat

97 ogical inhibition of DDR2 also inhibited the MT1-MMP-dependent cellular degradation of collagen film,

98 etion of RAB7, FYCO1, or Protrudin inhibited MT1-MMP-dependent extracellular matrix degradation and c

99 ted monocytes degraded collagen matrix in an MT1-MMP-dependent manner, and MT1-MMP neutralization dec

100 In turn, LIMK1 and LIMK2 are required for MT1-MMP-dependent matrix degradation and cell invasion i

101 In turn, MT1-MMP-dependent PI3Kdelta activation regulates the imm

102 Specific siRNA inhibition of MT1-MMP did not suppress TGFbeta2-induced matrix contrac

103 s have revealed a novel mechanism regulating MT1-MMP during cellular invasion and have identified the

104 In this study, we investigated the role of MT1-MMP during various stages of osteosarcoma developmen

105 These data identify a critical ARF6-JIP-MT1-MMP-dynein-dynactin-kinesin-1 axis promoting an inva

106 r JIP3/JIP4 in breast tumor cells results in MT1-MMP endosome mispositioning and reduces MT1-MMP exoc

107 tivity in a tug-of-war mechanism, leading to MT1-MMP endosome tubulation and exocytosis.

108 yndrome protein and scar homologue (WASH) on MT1-MMP endosomes on which they recruit dynein-dynactin

109 r prototype that targets the cellular active MT1-MMP enzyme alone.

110 expressed, fully functional, active cellular MT1-MMP enzyme are roughly equal to 1 x 10(5) molecules/

111 mounts of the cell surface-associated active MT1-MMP enzyme in multiple cancer cell types, including

112 cell-surface levels of the active, TIMP-free MT1-MMP enzyme.

113 MT1-MMP exists in various forms: a 63-kDa proenzyme is s

114 MT1-MMP endosome mispositioning and reduces MT1-MMP exocytosis and tumor cell invasion.

115 ane, enabling both invadopodia outgrowth and MT1-MMP exocytosis.

116 Although Slug increased MT1-MMP expression and ERK1/2 activity, Slug-expressing

117 e an inverse correlation between MTCBP-1 and MT1-MMP expression both in cultured cell lines and human

118 We find that active Notch1 and MT1-MMP expression correlate significantly in over 70% o

119 Gene silencing of MT1-MMP expression further demonstrated its requirement

120 anoma cells affects Notch1 cleavage, whereas MT1-MMP expression in ADAM10/17 double knock-out fibrobl

121 Modulation of MT1-MMP expression in melanoma cells affects Notch1 clea

122 A potential physiological stimulus for MT1-MMP expression is fibrillar collagen, and it has bee

123 orrelation between tumor signals and in vivo MT1-MMP expression levels.

124 in RGC axons and Muller glia, mimicking the MT1-MMP expression pattern seen in rabbits and neonatal

125 he acquisition of either wild-type or mutant MT1-MMP expression results in altered cohesion of epithe

126 reduction in RhoA and Cdc42 GTPase activity, MT1-MMP expression, and MMP-9 secretion.

127 x 10(6) range in the cells with the enforced MT1-MMP expression.

128 hanced migration speed primarily by inducing MT1-MMP expression.

129 nd membrane type 1 matrix metalloproteinase (MT1-MMP) expression.

130 Matrix proteolysis mediated by MT1-MMP facilitates the invasive migration of tumor cell

131 We find that this interaction displaces MT1-MMP from invadopodia, thereby attenuating their numb

132 st-tumor cell lines impaired the delivery of MT1-MMP from late endocytic storage compartments to the

133 dynamin-2, which control the trafficking of MT1-MMP from late endosome to the plasma membrane and pl

134 activation in HT1080 fibrosarcoma cells and MT1-MMP function in MDA-MB231 breast cancer cells were n

135 Putative MT1-MMP functions in trophoblasts were determined using

136 MT-LOOP region of MT1-MMP (LOOPAb) inhibited MT1-MMP functions, fully mimicking the phenotype of the

137 tion to cell adhesion complexes and regulate MT1-MMP functions.

138 it has been shown that it up-regulates both MT1-MMP gene and functions in various cell types.

139 CSF-2), granulocyte CSF (G-CSF, CSF-3), and MT1-MMP gene expression.

140 el and human osteosarcoma cells in which the MT1-MMP gene was knocked out using CRISPR/Cas9.

141 In order to study specificity for MT1-MMP, GNP-ActFP is treated to HT1080 and MCF7 cells,

142 MT1-MMP has a short intracellular domain (ICD) that has

143 Membrane type 1-matrix metalloproteinase (MT1-MMP) has an essential role in matrix degradation and

144 While changes in solvation of MT1-MMP have been recently studied, little is known abou

145 In human TB granulomas, MT1-MMP immunoreactivity was observed in macrophages thr

146 how the requirement of the metalloproteinase MT1-MMP in endothelial cells and fibroblasts, but not ca

147 We hypothesized that reduced placental MT1-MMP in FGR impairs trophoblast functions.

148 We conclude that reduced placental MT1-MMP in FGR may contribute to the impaired trophoblas

149 trong expression of MT1-MMP, but the role of MT1-MMP in osteosarcoma progression is currently unknown

150 unctional importance of the interaction with MT1-MMP in pericellular matrix degradation and mesenchym

151 Here, we investigated the role of MT1-MMP in the dissemination of ESCC.

152 etect endogenous and overexpressed exogenous MT1-MMP in the Eca109 and Eca9706 cell lines, respective

153 tial expression pattern of MMP-2, -3, -9 and MT1-MMP in the healthy mouse retina.

154 and MaCSCs as well as surface expression of MT1-MMP in tumor cells harboring the P878A/P881A mutatio

155 We observed a strong expression of MT1-MMP in wildtype cells of both primary tumors and lun

156 ndependent manner, and upregulates MMP-3 and MT1-MMP, in addition to MMP-1.

157 The structure of MT1-MMP includes the hemopexin domain (PEX) that is dist

158 MT1-MMP induced EMT in ESCC both in vivo and in vitro, N

159 MT1-MMP-induced EMT led to increase migration and invasi

160 Transwell assay was used to estimate MT1-MMP-induced invasion and metastasis.

161 a membrane type 1 matrix metalloproteinase (MT1-MMP) inducer, which increased granulocyte macrophage

162 A recent study has revealed that MT1-MMP induces epithelial-to-mesenchymal transition (EM

163 e for the development of novel and selective MT1-MMP inhibitors that specifically target the PEX doma

164 l exosite target region to develop selective MT1-MMP inhibitors.

165 These data identify a critical MT1-MMP/integrin/YAP/TAZ axis operative in the stem cell

166 Importantly, we find that MT1-MMP interacts with Notch1 at the cell membrane, supp

167 vading cells, N-WASP promoted trafficking of MT1-MMP into invasive pseudopodia, primarily from late e

168 ion through pharmacological targeting of the MT1-MMP intracellular signaling.

169 ssociation of KIF5B, surface localization of MT1-MMP, invadopodia, and invasion in cancer cells.

170 ng that cell-surface collagen degradation by MT1-MMP involves DDR2-mediated collagen signaling.

171 The membrane-anchored matrix metalloprotease MT1-MMP is a potent collagenolytic enzyme with a well-es

172 MT1-MMP is also regulated as a membrane protein through

173 Taken together, we demonstrate that MT1-MMP is central to two key elements of TB pathogenesi

174 Understanding how MT1-MMP is delivered to the surface of tumor cells is es

175 s reported in other cancers, tumor-expressed MT1-MMP is dispensable for all stages of osteosarcoma pr

176 ow that the membrane-bound metalloproteinase MT1-MMP is enriched not only at podosomes but also at di

177 MT1-MMP is highly expressed in various types of cancer a

178 In this study, we report that MT1-MMP is mono-ubiquitinated at its unique lysine resid

179 Polarized targeting and deposition of MT1-MMP is pivotal for metastasis.

180 MT1-MMP is regulated as a proteinase by activation and c

181 MT1-MMP is stable and active over a wide range of temper

182 evidence shows that the cytoplasmic tail of MT1-MMP is subjected to phosphorylation, and this post-t

183 es the processing of Notch1, indicating that MT1-MMP is sufficient to promote Notch1 activation indep

184 Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a key enzyme in these cellular processes.

185 Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a membrane-bound MMP that is highly expresse

186 Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy.

187 Membrane type 1-matrix metalloproteinase (MT1-MMP) is associated with enhanced tumorigenicity in m

188 Importantly, the majority of MT1-MMP islets are reused as sites of podosome reemergen

189 MT1-MMP islets become apparent upon podosome dissolution

190 MT1-MMP islets thus act as cellular memory devices that

191 lonal antibody against MT1-MMP, raised in an MT1-MMP knock-out mouse.

192 ng function by Y315F endophilin A2 mutant or MT1-MMP knockdown reduced markers for EMT and MaCSC acti

193 ll invasion by facilitating translocation of MT1-MMP-laden endosomes to the plasma membrane, enabling

194 magnitude of LV myocardial growth, altering MT1-MMP levels caused specific matrix-dependent changes

195 MT1-MMP levels were found to be correlated with the dept

196 MT1-MMP localization was for the first time studied in a

197 pecifically recognizes the MT-LOOP region of MT1-MMP (LOOPAb) inhibited MT1-MMP functions, fully mimi

198 This novel link between LIMK1/2 and MT1-MMP may have important consequences for therapeutic

199 certain MMP types, such as membrane type-1 (MT1) MMP, may also be involved in profibrotic cascades t

200 N-terminal sequencing of the MT1-MMP-mediated cleaved products and mutational analyse

201 entive properties of diet-derived EGCG alter MT1-MMP-mediated intracellular signaling.

202 th concentric remodeling), a 60% increase in MT1-MMP-mediated LTBP-1 hydrolysis and a 190% increase i

203 PO, significant differences in LV function, MT1-MMP-mediated LTBP-1 hydrolysis, and collagen content

204 ene expression, and this process required an MT1-MMP-mediated sequential activation of the Src and JA

205 ed membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growt

206 -peptide substitution (p.Thr17Arg) decreases MT1-MMP membrane localization with consequent impairment

207 Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP-14) is a transmembrane collagenase highly e

208 antagonist SB203580, downregulated MMP-9 and MT1-MMP/MMP-14 expressions by FN-stimulated macrophages,

209 controls FN-mediated inductions of MMP-9 and MT1-MMP/MMP-14.

210 n of the membrane-anchored metalloproteinase MT1-MMP (Mmp14) in mesenchymal progenitors, but not in c

211 Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP14) is a zinc-dependent type I transmembrane

212 by membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14), the main invadopodial matrix degradative

213 te membrane-type 1 matrix metalloproteinase (MT1-MMP; MMP14), which functions in actin-based pseudopo

214 MT1-MMP modulates inflammatory responses in a protease-i

215 MT1-MMP mRNA and active enzyme was quantified in placent

216 In FGR placentas, levels of MT1-MMP mRNA and of active MT1-MMP protein were reduced

217 In patients with TB, induced sputum MT1-MMP mRNA levels were increased 5.1-fold compared wit

218 reas overexpression of a nonphosphorylatable MT1-MMP mutant (Y573F) abrogated CSF-2 and CSF-3 transcr

219 mesenchymal tumor cell invasion, whereas in MT1-MMP-negative cells, palladin overexpression was insu

220 n matrix in an MT1-MMP-dependent manner, and MT1-MMP neutralization decreased collagen degradation by

221 an in vivo setting, mice heterozygous for an MT1-MMP-null allele display a distinct survival advantag

222 ing a potential direct cleavage mechanism of MT1-MMP on Notch1, and that MT1-MMP-dependent activation

223 e MT-LOOP effectively inhibited functions of MT1-MMP on the cell surface, including proMMP-2 activati

224 he membrane type 1 matrix metalloproteinase (MT1-MMP or MMP-14) is a collagenase that is key in leuko

225 Membrane type 1-matrix metalloproteinase (MT1-MMP or MMP-14) is a zinc-transmembrane metalloprotea

226 ations in membrane type-1 metalloproteinase (MT1-MMP or MMP14).

227 h for two distinct MMP proteases, MMP-12 and MT1-MMP (or MMP-14).

228 PO in MT1-MMP overexpression increased LTBP-1 hydrolysis (18%)

229 and transgenic mice with cardiac-restricted MT1-MMP overexpression or MT1-MMP reduced expression und

230 Although LV mass was similar among WT, MT1-MMP overexpression, and MT1-MMP reduced expression a

231 that the previously described Src-dependent MT1-MMP phosphorylation is a prerequisite for ubiquitina

232 The present study tested the hypothesis that MT1-MMP plays a direct role in the matrix remodeling res

233 tion of F-actin binding protein cortactin to MT1-MMP-positive endosomes and invadopodia formation and

234 , which is present in F-actin-rich puncta on MT1-MMP-positive endosomes and regulates cortactin assoc

235 Protrudin formed contact sites with MT1-MMP-positive endosomes that contained the RAB7-bindi

236 hat LIMK1 regulates cortactin association to MT1-MMP-positive endosomes, while LIMK2 controls invadop

237 sm that involves tubular connections between MT1-MMP-positive late endosomes and the plasma membrane

238 In conclusion, our results suggest that MT1-MMP promotes ESCC invasion and metastasis.

239 MMP2 and MT1-MMP protein levels were analyzed by ELISA and Wester

240 MT1-MMP protein was localized in first-trimester and ter

241 centas, levels of MT1-MMP mRNA and of active MT1-MMP protein were reduced (-34.2%, P < 0.05, and -21.

242 ns of a specific monoclonal antibody against MT1-MMP, raised in an MT1-MMP knock-out mouse.

243 nvadopodia formation and the polarization of MT1-MMP recycling compartments, required for invadopodia

244 imilar among WT, MT1-MMP overexpression, and MT1-MMP reduced expression after PO, significant differe

245 PO in MT1-MMP reduced expression reduced left atrial dimension

246 cardiac-restricted MT1-MMP overexpression or MT1-MMP reduced expression underwent PO for 4 weeks.

247 By effecting ECM remodeling, MT1-MMP regulates stem cell shape, thereby activating a

248 Upon MT1-MMP's arrival at the plasma membrane in pseudopodia,

249 the putative membrane interaction region of MT1-MMP (Ser466Pro) resulted in lower enzyme activation

250 -3 in concanavalin A-activated MSCs requires MT1-MMP signaling and is inhibited by EGCG.

251 melanoma cells and identify Notch1 as a new MT1-MMP substrate that plays important biological roles

252 fection of primary human monocytes increased MT1-MMP surface expression 31.7-fold and gene expression

253 cyte networks caused a 17.5-fold increase in MT1-MMP surface expression dependent on p38 MAPK and G p

254 inkage through the LINC complex and triggers MT1-MMP surface-exposure to facilitate nucleus movement.

255 the submesothelial collagen matrix on which MT1-MMP-T567E MCAs rapidly disperse.

256 Cells expressing MT1-MMP-T567E phosphomimetic mutants exhibit enhanced ce

257 Furthermore, MCAs formed from MT1-MMP-T567E-expressing cells adhere avidly to both int

258 ocated to the cell membrane for simultaneous MT1-MMP/TACE inhibition.

259 FAs and also provide molecular insights into MT1-MMP targeting and function.

260 arative work with an equipotent radiolabeled MT1-MMP targeting antibody demonstrated starkly differen

261 cycle and identify a structural function of MT1-MMP that is independent of its proteolytic activity.

262 nd membrane type 1 matrix metalloproteinase (MT1-MMP), the latter of which we recently identified as

263 sed not only to visualize the trafficking of MT1-MMP through the cell compartment, but also to quanti

264 tant role for SNARE-regulated trafficking of MT1-MMP to invadopodia during cellular invasion of ECM.

265 Trafficking of MT1-MMP to invadopodia is required for the function of t

266 irected recruitment of the metalloproteinase MT1-MMP to invadopodia plays a critical role in this inv

267 ediated membrane traffic in the transport of MT1-MMP to invadopodia.

268 3)PYAYIREG(170)), as an essential region for MT1-MMP to promote cellular invasion.

269 of the transmembrane matrix metalloprotease, MT1-MMP to promote invasive behaviour leading to basemen

270 te membrane type-1 matrix metalloproteinase (MT1-MMP) to podosomes or invadosomes to break extracellu

271 the membrane-type 1 matrix metalloprotease (MT1-MMP) to shedding microvesicles.

272 of membrane type I matrix metalloproteinase (MT1-MMP) to the leading edge is thought to be a crucial

273 eases, such as the transmembrane collagenase MT1-MMP, together with actin-based protrusions, to break

274 synthesizes a pool of PI(4)P that maintains MT1-MMP traffic in the degradative pathway and suppresse

275 leobindin-1 (NUCB1) is critical for MMP2 and MT1-MMP trafficking along the Golgi apparatus.

276 st-translational modification is involved in MT1-MMP trafficking as well as in modulating cellular in

277 PI4KIIbeta depletion caused increased MT1-MMP trafficking to invasive structures at the plasma

278 extension of invasive pseudopods into which MT1-MMP traffics and for providing the correct cytoskele

279 and Vimentin expression was upregulated upon MT1-MMP transfection into cells.

280 NMR derived structural models indicate that MT1-MMP transiently associates with bicelles and cells t

281 However, pathways of MT1-MMP up-regulation are not clearly understood.

282 a membrane in pseudopodia, N-WASP stabilized MT1-MMP via direct tethering of its cytoplasmic tail to

283 ted delivery of the matrix metalloproteinase MT1-MMP via endosomal transport by mechanisms that are n

284 al and fluorogenic activity of GNP-ActFP for MT1-MMP via fluorescence multi-reader.

285 pression of membrane type 1 metalloprotease (MT1-MMP) via down-regulating the kinesin-like protein KI

286 Overexpression of MT1-MMP was confirmed in Kazakh ESCC patients.

287 Expression of MT1-MMP was detected by immunohistochemistry and tissue

288 MT1-MMP was expressed predominantly in the syncytiotroph

289 Basal expression of MMP-2,-3, -9 and MT1-MMP was found in the retina of healthy, adult mice.

290 c peptide with subnanomolar affinity towards MT1-MMP was identified, and its radioconjugate showed se

291 tial expression pattern of MMP-2, -3, -9 and MT1-MMP was studied in the healthy mouse retina via immu

292 s, including MMP-13, MMP-8, MMP-2, MMP-9, or MT1-MMP, we identify the membrane-anchored MMP, MT1-MMP,

293 cells that express low endogenous levels of MT1-MMP were engineered to express wild-type MT1-MMP, a

294 ed membrane type-1 matrix metalloproteinase (MT1-MMP) were selectively up-regulated and coexpressed i

295 t cancer HCC1806 cells is partly mediated by MT1-MMP, which also regulates collagen-induced receptor

296 A tempting target is the membrane-associated MT1-MMP, which has well-documented importance in matrix

297 ed expression of mesenchymal genes including MT1-MMP, which was required for collagen-stimulated inva

298 ctural and energetic changes associated with MT1-MMP while interacting with substrates.

299 was accompanied by reduced colocalization of MT1-MMP with membranes containing the endosomal markers

300 By using an MT1-MMP Y573A mutant or the Src family inhibitor PP2, we