ライフサイエンスコーパス: Marburgvirus

1 of nonadapted wild-type (wt) Ebolavirus and Marburgvirus.

2 nt in various RNA viruses, including HIV and Marburgvirus.

3 appears to be the major virulence factor for marburgviruses.

4 focused on the highly pathogenic ebola- and marburgviruses.

5 any viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and mo

6 of the secreted ebolavirus glycoproteins on marburgvirus and ebolavirus cell entry, using Fc-tagged

7 inct from that of Ebola virus (EBOV) (genera Marburgvirus and Ebolavirus, respectively).

8 Viruses within Marburg marburgvirus and Sudan ebolavirus species can be traced

9 exception of Reston and Bombali viruses, the marburgviruses and ebolaviruses (family Filoviridae) cau

10 at (ERB) is a natural reservoir host for the marburgviruses and evidence suggests that bats are also

11 m Ebolavirus Zaire and Sudan species and the Marburgvirus Angola strain expressed in a DNA vaccine.

12 Marburgviruses are zoonotic pathogens that cause lethal

13 Ebolaviruses and marburgviruses belong to the family Filoviridae and caus

14 Filoviruses, including ebolaviruses and marburgviruses, can cause severe and often fatal disease

15 Ebolavirus and Marburgvirus cause severe hemorrhagic fever with high mo

16 irus vaccine vectors using wt Ebolavirus and Marburgvirus challenge strains.

17 s protected naive animals from EBOV, but not Marburgvirus, challenge.

18 n of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and "cuevaviruses") cause

19 While the marburgviruses exhibit high overall genetic diversity (u

20 1,2), ebolaviruses and cuevaviruses, but not marburgviruses, express two secreted glycoproteins, solu

21 Viruses in the Ebolavirus and Marburgvirus genera (family Filoviridae) have been assoc

22 ad-spectrum therapies against members of the Marburgvirus genus, including Marburg virus (MARV) and R

23 Neither the marburgvirus GP1 fragment nor that of ebolavirus bound a

24 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell

25 or for the deadly filoviruses Ebolavirus and Marburgvirus has yet to be identified and characterized.

26 These studies provide insights into how marburgviruses manipulate the host for enzymes, metaboli

27 Filoviruses, marburgvirus (MARV) and ebolavirus (EBOV), are causative

28 Marburgvirus (MARV) infections are generally lethal in h

29 s Zaire ebolavirus (ZEBOV) and Lake Victoria marburgvirus (MARV) were not affected by these condition

30 morrhagic fever (MHF), the disease caused by marburgvirus (MARV), and has created a bottleneck in the

31 irus (ZEBOV), Reston Ebolavirus (REBOV), and Marburgvirus (MARV), using transcriptional profiling and

32 The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan

33 BOV), Cote d'Ivoire ebolavirus (CIEBOV), and Marburgvirus (MARV).

34 We discovered a fully human, pan-marburgvirus monoclonal antibody, MARV16, that broadly n

35 In primate cells, the Lake Victoria marburgvirus Musoke strain (MARV) VP40 matrix protein an

36 hat is both captor and tracer for polyvalent Marburgvirus nucleoprotein.

37 iruses pseudotyped with either Lake Victoria marburgvirus or Zaire ebolavirus GP(1,2).

38 This is in contrast to the 1998 to 2000 marburgvirus outbreak, where evidence of several virus g

39 cation strategies employed by the ebola- and marburgviruses, respectively.

40 Partial marburgvirus RNA sequence analysis revealed up to 21% nu

41 ope within the fusion loop of ebolavirus and marburgvirus species.

42 severe viral infection caused by the Marburg marburgvirus species.

43 f Marburg virus (MARV) species Lake Victoria marburgvirus, strain Musoke, indicate only a few regions

44 potential of all filovirus species: Marburg marburgvirus, Tai Forest ebolavirus, Reston ebolavirus,

45 tely 7%) from the main group of East African marburgviruses than one might expect given the large geo

46 erentiated between the genera Ebolavirus and Marburgvirus The amount of filovirus RNA that could be d

47 species of Ebolavirus and several strains of marburgvirus, the current immunotherapeutics primarily t

48 ese new genera are similar to the ebola- and marburgviruses, the other two, discovered in saltwater f

49 leotide sequences may confer activity across marburgvirus variants.

50 In contrast, structures of marburgvirus VP35 show that it primarily coats the dsRNA

51 Marburgvirus was also included despite the fact that the

52 Surprisingly, marburgvirus was confirmed (12 of 15 specimens) as the c

53 The investigational Ebolavirus and Marburgvirus WT GP DNA vaccines were safe, well tolerate