ライフサイエンスコーパス: Me

1 Me(2)SPM administration to mice revealed that Me(2)SPM s

2 Me(2)SPM can functionally substitute for the native poly

3 Me-iPLEX was used to classify CLL samples into 1 of 3 kn

4 e thiophene ring in 2-chloro(or bromo)-5-(1'-Me(3)SiO-1'-trifluoromethyl-alkyl)thiophenes in Bronsted

5 e, in the presence of dimethyl substituent 1(Me), regioselective gamma-arylation is favored by 3.4 kc

6 Ti(III) metallocene complexes Cp*(2)TiMe (1(Me)) and Cp*(2)TiH (1(H)) (Cp* = eta(5)-C(5)Me(5)) as th

7 py (muSR) when a solution of MesP=CMe(2) (1: Mes=2,4,6-trimethylphenyl) was exposed to a beam of posi

8 (2,11-Me(2)Spm), 3,10-dimethylspermine (3,10-Me(2)Spm), 2-methylspermine, and 2,2-dimethylspermine.

9 d Spm analogues: 2,11-dimethylspermine (2,11-Me(2)Spm), 3,10-dimethylspermine (3,10-Me(2)Spm), 2-meth

10 indicate that the (R,R)-diastereomer of 1,12-Me(2)SPM represents a promising lead compound in develop

11 [Fe(II)(Me(3)NTB)(CH(3)CN)](CF(3)SO(3))(2) (Me(3)NTB = tris((1-methyl-1H-benzo[d]imidazol-2-yl)methy

12 fide, [K(2.2.2-cryptand)][(Me) LZn(S)] (2) ((Me) L={(2,6-(i) Pr(2) C(6) H(3) )NC(Me)}(2) CH), was iso

13 allizes with AlMe(3) as [Sc(AlMe(4))(3)(Al(2)Me(6))(0.5)] and decomposes at ambient temperature in n-

14 tathesis reactions from [Sc(AlMe(4))(3)(Al(2)Me(6))(0.5)] and KCp* (Cp* = C(5)Me(5)).

15 Ultimately, cationized [Sc(AlMe(4))(3)(Al(2)Me(6))(0.5)] was employed in isoprene polymerization, le

16 Rhodium complexes modified by P (t)Bu(2)Me catalyze formate-mediated aldehyde-vinyl bromide redu

17 ive ligand and modified norbornene (NBE-CO(2)Me), as well as taking advantage of the statistics, are

18 (6)H(4), 2-BrC(6)H(4), 2-CNC(6)H(4), 2-(CO(2)Me)C(6)H(4), 2-(TMS-C=C)C(6)H(4)) present on anilines ca

19 dimethylbiphenyl-4,4'-dicarboxylic acid (H(2)Me(2)BPDC) and biphenyl-4,4'-dicarboxylic acid (H(2)BPDC

20 (R(2))M(CO)(2)Tp'] (M = Mo, W; R(1) = R(2) = Me or R(1) = H, R(2) = SiMe(3), Ph; Tp' = kappa(3)-N,N',

21 ated (peroxo)diiron complex Fe(III)(2)(O(2))(Me(3)TACN)(2)(S(2)SiMe(2))(2) (2) that was characterized

22 ate-ligated cobalt-superoxo species Co(O(2))(Me(3)TACN)(S(2)SiMe(2)) (2) that was characterized spect

23 6-substituent on the purine ring (R = NH(2), Me, NHBz, OBz).

24 h(4)) (Ln = Gd, Dy; R = NMe(2) (1), OEt (2), Me (3), F (4); bpym = 2,2'-bipyrimidine).

25 riphenylene (HATP) with [Cu(Me(3)tacn)](2+) (Me(3)tacn = 1,4,7-trimethyl-1,4,7-triazacyclononane) pro

26 and its abstraction of a H-atom to afford 3(Me).

27 rted stannylene ((Mes) TerSn(Si(t) Bu(3) ) [(Mes) Ter=2,6-(2,4,6-Me(3) C(6) H(2) )(2) C(6) H(3) ] ena

28 d U(IV)/U(IV) nitride complex [Na(DME)(3)][((Me(3)Si)(2)N)(2)U(mu-N)(mu-kappa(2):CN-CH(2)SiMe(2)NSiMe

29 acid (H(2)sq) and 2,3-dimethylpyrazine (2,3-Me(2)pyz) results in crystallization of a new organic an

30 lectric (PE) state can be formulated as (2,3-Me(2)pyzH(+))(2)(Hsq(2)(3-))(H(5)O(2)(+)), whereas the A

31 ereas the AFE phase can be described as (2,3-Me(2)pyzH(+))(Hsq(-))(H(2)O).

32 a new organic antiferroelectric (AFE), (2,3-Me(2)pyzH(+))(Hsq(-)).H(2)O (1), which possesses a layer

33 e(CO)(4) [NHC = IPr = C{(NDipp)CH}(2) for 3; Me-IPr = C{(NDipp)CMe}(2) for 4; Dipp = 2,6-iPr(2)C(6)H(

34 transuranic hydrocarbyl complex, Np[eta(4) -Me(2) NC(H)C(6) H(5) ](3) (1), from reaction of NpCl(4)

35 uril pairs (two Pr(4)Me(4)BU[4] and two Bn(4)Me(4)BU[4] stereoisomers, 4b, 4d, 5b, and 5d) were clear

36 l" arrangement of the N-substituents in Bn(4)Me(4)BU[4], 5a, clearly observed by X-ray spectroscopy a

37 inherently chiral bambusuril pairs (two Pr(4)Me(4)BU[4] and two Bn(4)Me(4)BU[4] stereoisomers, 4b, 4d

38 Chiral Pr(4)Me(4)BU[4], 4b, was resolved by chiral high-performance

39 idged boronic acid anhydride 1 with LiAlH(4)/Me(3)SiCl afforded the corresponding 1,8-naphthalenediyl

40 rst time, very electron-rich substituents (4-Me(2)NC(6)H(4), 3-(OH)C(6)H(4), pyrrol-2-yl) originating

41 saturated compounds, we identified Li(2)[4] (Me substituents at boron) as the best performing catalys

42 n an Am(3+) organometallic complex, [Am(C(5) Me(4) H)(3) ] (1).

43 a(1)-C(5)Me(4)CH(2)py)(C,N)]PF(6), where C(5)Me(4)CH(2)py is 2-((2,3,4,5-tetramethylcyclopentadienyl)

44 complexes of formula [Ir(eta(5):kappa(1)-C(5)Me(4)CH(2)py)(C,N)]PF(6), where C(5)Me(4)CH(2)py is 2-((

45 nter, resulting in an Ir(eta(5):kappa(1)-C(5)Me(4)CH(2)pyN) tether-ring structure, as confirmed by th

46 , [Fe(III)(eta(5)-Cp*)(dppe)H](+) (Cp* = C(5)Me(5)(-), dppe = 1,2-bis(diphenylphosphino)ethane), to a

47 (Me)) and Cp*(2)TiH (1(H)) (Cp* = eta(5)-C(5)Me(5)) as the first isolable early transition metal prec

48 [MCl(2)Cp*](2) dimers (M = Rh, Ir; Cp* = C(5)Me(5)) in the presence of NaOAc to form cyclometalated C

49 **) = C(8)H(4)(1,4-Si(i)Pr(3))(2), Cp* = C(5)Me(5)) with ethene at atmospheric pressure produces the

50 allic cluster with formation of [(eta(5)-C(5)Me(5))(4)Rh(5)H(7)] serving as a deactivation pathway.

51 4))(3)(Al(2)Me(6))(0.5)] and KCp* (Cp* = C(5)Me(5)).

52 C-H bond activation at cationic [(eta(5)-C(5)Me(5))Ir(PMe(2)Ar')] centers is described, where PMe(2)A

53 cipation of dicationic species, [(eta(5)-C(5)Me(5))Ir(PMe(2)Ar')](2+), is proposed.

54 f the five-coordinate complexes [(eta(5)-C(5)Me(5))IrCl(PMe(2)Ar')](+), 2(Xyl)(+) and 2(Dipp)(+), int

55 mine-substituted rhodium complex (eta(5)-C(5)Me(5))Rh((Me)PhI)H ((Me)PhI = N-methyl-1-phenylethan-1-i

56 nergies of 51.8 kcal mol(-1) for (eta(5)-C(5)Me(5))Rh((Me)PhI)H and 51.1 kcal mol(-1) for (eta(5)-C(5

57 he organometallic precatalysts, [(eta(5)-C(5)Me(5))Rh(N-C)H] (N-C = 2-phenylpyridinyl (ppy) or benzo[

58 pared to the previously reported (eta(5)-C(5)Me(5))Rh(ppy)H (ppy = 2-phenylpyridine).

59 )PhI)H and 51.1 kcal mol(-1) for (eta(5)-C(5)Me(5))Rh(ppy)H.

60 int to the propensity of Cp*( exo-eta(4)-C(5)Me(5)H)Co to mediate hydride (H(-)) transfer.

61 ably assigning the Cp*( exo/ endo-eta(4)-C(5)Me(5)H)Co(+) species.

62 e energy (BDFE(C-H)) for Cp*( exo-eta(4)-C(5)Me(5)H)Co(+).

63 protonated isomers Cp*( exo/ endo-eta(4)-C(5)Me(5)H)Co(+).

64 B((t)BuIm)(3)Fe-NC-Mo(N(t)BuAr)(3) (Ar = 3,5-Me(2)C(6)H(3)) is readily assembled from a new four-coor

65 substrate analog dCMPNPP and the products 5-Me-dCMP and dCMP.

66 tion of 1a with isocyanide Xyl-NC (Xyl = 2,6-Me(2)C(6)H(3)), isoelectronic with CO.

67 Reduction of Th(OC(6)H(2)(t)Bu(2)-2,6-Me-4)(4) using either KC(8) or Li in THF forms a new exa

68 [K(THF)(5)(Et(2)O)][Th(OC(6)H(2)(t)Bu(2)-2,6-Me-4)(4)] and [Li(THF)(4)][Th(OC(6)H(2)(t)Bu(2)-2,6-Me-4

69 )] and [Li(THF)(4)][Th(OC(6)H(2)(t)Bu(2)-2,6-Me-4)(4)].

70 s) TerSn(Si(t) Bu(3) ) [(Mes) Ter=2,6-(2,4,6-Me(3) C(6) H(2) )(2) C(6) H(3) ] enables activation of w

71 iron complex, Fe(HMTO)(2) [HMTO=O-2,6-(2,4,6-Me(3) C(6) H(2) )(2) C(6) H(3) ], that is capable of per

72 [RGe(O)(NHC)(2)]X (R = (Mes)Ter = 2,6-(2,4,6-Me(3)C(6)H(2))(2)C(6)H(3); NHC = IMe(4) = 1,3,4,5-tetram

73 acnac = {[(Mes)NC(Me)](2)CH}(-), Mes = 2,4,6-Me(3)C(6)H(2)].

74 n of 1 with three equivalents of HE(2) C(2,6-Mes(2) -C(6) H(3) ) (E=O, S) yields [(2,6-Mes(2) -C(6) H

75 ,6-Mes(2) -C(6) H(3) ) (E=O, S) yields [(2,6-Mes(2) -C(6) H(3) )CE(2) ](3) Np(THF)(2) , maintaining t

76 Mes)TerEP(IDipp) (E = Ge, Sn; (Mes)Ter = 2,6-Mes(2)C(6)H(3), IDipp = C([N-(2,6-iPr(2)C(6)H(4))CH](2))

77 stereoselective copolymerizations of rac-8DL(Me) with rac-8DL(R) (R=Et, Bu) have yielded high-molecul

78 that the higher rates observed with the 2,9-Me(2)-phen ligand are due to a more thermodynamically fa

79 alyst containing the sterically hindered 2,9-Me(2)-phen ligand but accompanying rapid inhibition by h

80 kyl-dG lesions, with the alkyl group being a Me, Et, nPr, iPr, nBu, iBu, or sBu, in several human cel

81 d 1,4,2-diazaphospholium triflate salts by a Me(3)SiOTf-mediated self-condensation of dichlorophospha

82 or to bulkier groups (e.g., Et, pTol), and a Mes substituent is even prohibitively large.

83 rgetic span analysis suggest the role of a [(Me(3)Si)(2)N](2)La-OCHR(NR'(2))[HBpin] active catalyst,

84 fibroblasts from SRS patients can accumulate Me(2)SPM, resulting in significantly decreased spermidin

85 ylacetylene to yield the imide acetylide [{((Me(3)Si)(2)N)(2)U(THF)}(2)(mu-N)][((Me(3)Si)(2)N)(2)U(et

86 compound [(68)Ga]Ga-NODAGA-Lys(Cy5**)-AEEAc-[Me-Arg(8),Tle(12)]-NT(7-13) as the one with the most pro

87 Two groups (Segal et al., Med Care.

88 modified condensation method produced alpha-Me beta-Me cyclophane.

89 ents and by comparison to trigonal analogue (Me(2) N)(3) P.Fp(+) (i.e. 1b.Fp(+) ), which is inert to

90 ect comparison to its carbonaceous analogues Mes-[10]CPP and [10]CPP.

91 Using both 2-FDG and Me-4FDG should provide a more complete picture of glucos

92 Utilizing both 2-FDG and Me-4FDG should provide a more complete picture of glucos

93 ng organic matter, but MeHg (CH(3)Hg(+)) and Me(2)Hg ((CH(3))(2)Hg) have been shown to form also in s

94 iridium insertion in both unsubstituted and Me-substituted ring C-C bonds, at 150 degrees C a single

95 ysts rac-[Me(2) Si(indenyl)(2) ]ZrMe(2) and [Me(2) C(Cp)(fluorenyl)]ZrMe(2) , respectively.

96 lexes [(Me(3)tacnCu)(3)(HOTP)](3+) (1) and [(Me(3)tacnCu)(3)(HITP)](4+) (2) (HOTP, HITP = hexaoxy- an

97 benes (NHCs), where the 4,5-substituents are Me, H, or Cl.

98 ATAC-Me uncovers a significant disconnect between chromatin a

99 (2020) develop a new technology, called ATAC-Me, and discover that removal of DNA methylation is not

100 eir temporal relationship, we developed ATAC-Me, which probes accessibility and methylation from sing

101 ted observation highlights the value of ATAC-Me in constructing precise molecular timelines for under

102 a intramolecular borylation and sequential B-Mes bond cleavage in the presence of BBr(3) .

103 omplex {(Cu(BDI(Mes)))(2)(mu-C(6)H(6))} (BDI(Mes) = N,N'-bis(2,4,6-trimethylphenyl)pentane-2,4-diimin

104 mplexes {(BDI(Mes))CuAl(BDI(Dip))} and {(BDI(Mes))CuGa(BDI(Dip))}.

105 ate) in toluene afforded the complexes {(BDI(Mes))CuAl(BDI(Dip))} and {(BDI(Mes))CuGa(BDI(Dip))}.

106 I) beta-diketiminate copper complex {(Cu(BDI(Mes)))(2)(mu-C(6)H(6))} (BDI(Mes) = N,N'-bis(2,4,6-trime

107 Cyclophanes bearing Me, Et, and MeO cap substituents and beta-Me, Et, or Ph

108 ng Me, Et, and MeO cap substituents and beta-Me, Et, or Ph arm substituents are obtained, and a modif

109 d condensation method produced alpha-Me beta-Me cyclophane.

110 , but the most common ligands include BINAP, Me-Duphos, Josiphos, and related analogs.

111 he dehydrogenation of secondary amine-borane Me(2)NH.BH(3) supports a bond-metathesis/beta-hydride el

112 2-substituted resorcinols (R' = OH, Cl, Br, Me), allowing a third type of functionality to be regios

113 ophiles LiPHR (R = ferrocenyl, Ph, Cy, t-Bu, Mes* (Mes* = 2,4,6-(t-Bu)(3)C(6)H(2))), followed by trea

114 d via a decarbonilation reaction promoted by Me(3)SnLi.

115 latest thermal diffusion prediction model by Mes, Kok, and Tijssen combined with the Hansen solubilit

116 The process is accomplished by [(Me(3)P)(4)NiH]N(SO(2)CF(3))(2) in the presence of trifli

117 he gallium carbenoid Ga(Nacnac) (Nacnac=HC[C(Me)N(2,6-i-Pr(2) C(6) H(3) )](2) ).

118 )Mg((Dip)Nacnac)}(2)] (D = DMAP or :C{N(Me)C(Me)}(2)).

119 (Me)(2) (1 a, minor product) and MesPMu-C(.) Me(2) (1 b, major product), were detected by muon spin s

120 re compared to its isotopologue, MesPH-C(.) (Me)CH(2) Mu (2 a).

121 rms two radicals (Si- and P-centred); and c) Mes-substituted phosphasilene mainly forms one species o

122 rent receptor binding behavior of (R)- (11)C-Me-NB1 and (S)- (11)C-Me-NB1 raises awareness of a delic

123 demonstrating the specificity of (R)- (11)C-Me-NB1 binding to the human GluN2B-containing NMDA recep

124 sponse behavior was observed with (R)- (11)C-Me-NB1 but not with (S)- (11)C-Me-NB1.

125 Although (R)- (11)C-Me-NB1 displayed heterogeneous accumulation with high se

126 In vivo specificity of (R)- (11)C-Me-NB1 in the GluN2B-expressing cortex, striatum, thalam

127 behavior of (R)- (11)C-Me-NB1 and (S)- (11)C-Me-NB1 raises awareness of a delicate balance that is un

128 ty for the GluN2B-rich forebrain, (S)- (11)C-Me-NB1 revealed a homogeneous distribution across all br

129 Similar to rodent brain, (R)- (11)C-Me-NB1 showed in postmortem human brain tissues higher b

130 s: The radiosynthesis of (R)- and (S)- (11)C-Me-NB1 was accomplished in 42% +/- 9% (decay-corrected)

131 rate the translational relevance, (R)- (11)C-Me-NB1 was validated in autoradiographic studies using p

132 characteristics of the enantiomers of (11)C-Me-NB1, a recently reported PET imaging probe that targe

133 th (R)- (11)C-Me-NB1 but not with (S)- (11)C-Me-NB1.

134 he [(((t.Bu)ArO)(3)tacn)U(III)((Me)cy-C6)].((Me)cy-C6) adduct.

135 (Crit Care Med 2019; 47:1505-1512).

136 CDDO-Me treatment redirects the TAM transcriptional profile,

137 nthetic triterpenoid CDDO-methyl ester (CDDO-Me) converts breast TAMs from a tumor-promoting to a tum

138 noids including CDDO, its methyl ester (CDDO-Me, bardoxolone methyl), and its imidazolide (CDDO-Im) e

139 Moreover, mice fed CDDO-Me demonstrated significant reductions in numbers of CD4

140 In CDDO-Me-treated mice, both the absolute number and proportion

141 Unlike monofunctional CDDO-Me, the bifunctional analog, CDDO-Im, has a second react

142 lts demonstrate for the first time that CDDO-Me relieves immunosuppression in the breast TME and unle

143 We show now that CDDO-Me remodels the breast TME, redirecting TAM activation a

144 We demonstrate that CDDO-Me significantly attenuates IL-10 and VEGF expression bu

145 at bifunctional CDDO-Im (in contrast to CDDO-Me), as low as 50 nM, can covalently transacylate argini

146 SiPr(i) (3) )(2) (CH(2) CH(2) SiPr(i) (2) CH(Me)CH(2) )}] reacts with 1As and 1P by alpha-proton abst

147 SiPr(i) (3) )(2) [CH(2) CH(2) SiPr(i) (2) CH(Me)CH(2) C(O)mu-P]}] (3) and the oxo complex [{Th(Tren(T

148 rial [(Mes)Nacnac = {[(Mes)NC(Me)](2)CH}(-), Mes = 2,4,6-Me(3)C(6)H(2)].

149 nglet oxygen with a cadmium-sulfur cluster, (Me(4)N)(2)[Cd(4)(SPh)(10)].

150 dented muoniated free radicals, MesP(.) -CMu(Me)(2) (1 a, minor product) and MesPMu-C(.) Me(2) (1 b,

151 terization of a Co(II) dithiolato complex Co(Me(3)TACN)(S(2)SiMe(2)) (1) are reported.

152 U(III)/U(IV) imide cyclometalate complex, [((Me(3)Si)(2)N)(2)(THF)U(mu-NH)(mu-kappa(2):C,N-CH(2)SiMe(

153 tride, namely, the U(III)/U(IV) complex, [{((Me(3)Si)(2)N)(2)U(THF)}(2)(mu-N)], 4.

154 e an imide hydride U(III)/U(IV) complex, [{((Me(3)Si)(2)N)(2)U(THF)}(2)(mu-NH)(mu-H)], 9.

155 he cationic U(IV)/U(IV) nitride complex, [{((Me(3)Si)(2)N)(2)U(THF)}(2)(mu-N)][BPh(4)] (THF = tetrahy

156 ane) produces trigonal tricopper complexes [(Me(3)tacnCu)(3)(HOTP)](3+) (1) and [(Me(3)tacnCu)(3)(HIT

157 The parent compounds (Me(2)NH(2))(2)[M(2)L(3)] (M = Zn, Mn; H(2)L = 2,5-dichlo

158 Compounds [(Me(3)TACN)ScMe(3)] (+624.6 ppm) and [ScMe(3)(thf)(x)] (+

159 d" terminal Zn sulfide, [K(2.2.2-cryptand)][(Me) LZn(S)] (2) ((Me) L={(2,6-(i) Pr(2) C(6) H(3) )NC(Me

160 hCCH and N(2) O to form [K(2.2.2-cryptand)][(Me) LZn(SH)(CCPh)] (4) and [K(2.2.2-cryptand)][(Me) LZn(

161 LZn(SH)(CCPh)] (4) and [K(2.2.2-cryptand)][(Me) LZn(SNNO)] (5), respectively, displaying both Bronst

162 lly disordered paramagnetic plastic crystal, Me-AZADO, to the ordered diamagnetic crystalline phase,

163 ,10,11-hexaaminotriphenylene (HATP) with [Cu(Me(3)tacn)](2+) (Me(3)tacn = 1,4,7-trimethyl-1,4,7-triaz

164 nation/metalation with mesitylcopper (CuMes; Mes: mesityl) or by transmetalation with cuprous precurs

165 nerated the cyclic phosphonium salt [cyclo-{(Mes)P}(2) P(Mes)(2) ][BAr(F) (4) ].CyMe through the cycl

166 Additional key transformations include DABAL-Me(3)-mediated lactone aminolysis and a mild TBD/ethyl t

167 ermine mimetic, (R,R)-1,12-dimethylspermine (Me(2)SPM), to reduce the intracellular spermidine pools

168 idate the role of the triterpenoid CF(3)DODA-Me in abrogating several of these tumor-promoting pathwa

169 CF(3)DODA-Me showed antiproliferative effects on tumor cells, alte

170 3,11-dioxoolean-1,12-dien-30-oate (CF(3)DODA-Me), a potent anticancer agent, were studied on cancer-l

171 is a positively charged group, for example, Me(2)NH(+), and the pai-donor is an electron-rich aromat

172 ophane, the hexabora[1(6) ]cyclophane B6-(F) Mes, in which six tricoordinate borane moieties alternat

173 studies uncover unique properties of B6-(F) Mes, including a low-lying and extensively delocalized L

174 yclic 2,4,6-tris(trifluoromethyl)phenyl ((F) Mes) groups serve not only to further withdraw electron

175 w secondary phosphine HPA (5), prepared from Me(2)NPA and DIBAL-H in 50% yield.

176 yl-4-deoxy-4-(18)F-fluoro-d-glucopyranoside (Me-4FDG).

177 ium complex (eta(5)-C(5)Me(5))Rh((Me)PhI)H ((Me)PhI = N-methyl-1-phenylethan-1-imine) exhibited highe

178 fragmentation of R,R'-BhPy(+), R,R' = H,H'; Me,Me'; H,OMe', respectively.

179 calculations for R,R'-BhPy(+) (R,R' = H,H'; Me,Me'; H,OMe'; Me,OMe'; OMe,OMe'; NPh(2),NPh(2)') predi

180 = tris(para-X-phenyl)corrole (X = CF(3), H, Me, and OCH(3)) and L = pyridine (py), trimethylamine (t

181 Smaller substituents (e.g., H, Me) are superior to bulkier groups (e.g., Et, pTol), and

182 i)(2)NR' or 5 with H(2)NR' or H(2)O (R' = H, Me, p-Tol).

183 ccompanied by an unusual migration of the H, Me, and Ph groups from germanium to the carbene ligand.

184 ansfer) for X = OMe, NMe(2) (data for X = H, Me, (t)Bu are intermediate between the extremes).

185 *), which, when coupled with hexasulfide, [{(Me)CN(i-Pr)}(2)CH](+)(2)[S(6)](2-) (4), and N-heterocycl

186 iradical [P(mu-NHyp)](2) (Hyp = hypersilyl, (Me(3)Si)(3)Si) with different isonitriles afforded a ser

187 that a new and serendipitously formed Ag(I) -Me-StackPhos complex efficiently catalyzes the highly se

188 (tBu-Xantphos)Ni(I) -Me and (tBu-Xantphos)Ni(I) -Et complexes undergo fast in

189 -{-C(O)-C(6)H(3)-5-R'-(C(O)PMe)}(2) (R' = I, Me, (t)Bu, Ph, and p-NCC(6)H(4)); the analogues m-{-C(O)

190 In this work, we show that [Fe(II)(Me(3)NTB)(CH(3)CN)](CF(3)SO(3))(2) (Me(3)NTB = tris((1-m

191 ractions in the [(((t.Bu)ArO)(3)tacn)U(III)((Me)cy-C6)].((Me)cy-C6) adduct.

192 Importantly, Me(2)SPM was detectable in brain tissue, the organ most

193 ped a novel assay, termed methylation-iPLEX (Me-iPLEX), for high-throughput quantification of targete

194 NpCl(4) (DME)(2) with four equivalents of K[Me(2) NC(H)C(6) H(5) ].

195 mbrane integrity (V2; 1.5 M methanol + 5.5 M Me(2)SO + 0.5 M sucrose + 10% egg yolk solution) was sel

196 e (3) was isolated as crystalline material [(Mes)Nacnac = {[(Mes)NC(Me)](2)CH}(-), Mes = 2,4,6-Me(3)C

197 s LiPHR (R = ferrocenyl, Ph, Cy, t-Bu, Mes* (Mes* = 2,4,6-(t-Bu)(3)C(6)H(2))), followed by treatment

198 rNCMe)(2)CH](-)), Ar = xylyl (Xyl), mesityl (Mes), 2,6-diethylphenyl (Dep), or 2,6-diisopropylphenyl

199 Upon addition of MesMgBr/Me(3)SiCl, 2 was readily converted to the tetraorganyl d

200 re, we synthesized and characterized methyl (Me)- and n-butyl (nBu)-PTEs in two diastereomeric config

201 gave the diboranium cation [MesB(mu-H)(2)(mu-Mes)BMes](+) featuring three bridge-bonds between two bo

202 the triboron cation [H(2)B(mu-H)(mu-Mes)B(mu-Mes)(mu-H)BH(2)](+).

203 yielded the triboron cation [H(2)B(mu-H)(mu-Mes)B(mu-Mes)(mu-H)BH(2)](+).

204 )O(3))Mg((Dip)Nacnac)}(2)] (D = DMAP or :C{N(Me)C(Me)}(2)).

205 These oligosilyl MOFs feature linear Si(n) Me(2n) (C(6) H(4) CO(2) H)(2) ligands (lin-Si(n) , n=2,

206 lide [{((Me(3)Si)(2)N)(2)U(THF)}(2)(mu-N)][((Me(3)Si)(2)N)(2)U(eta(1)-CCPh)(mu(2)-NH)(mu(2)-eta(2):et

207 ne, [{((Me(3)Si)(2)N)(2)U(THF)}(2)(mu-N)][{((Me(3)Si)(2)N)(3)U(mu-NH)U(N(SiMe(3))(2))}(2)(C(7)H(8))],

208 The X-ray crystallographic structure of N-Me-d-Gln(4),d-aza-Thr(8),Arg(10)-teixobactin reveals an

209 Methods: DOTA-D-Glu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1-Nal-NH(2) (DOTA-MGS5) radiolabeled with (11

210 ed as crystalline material [(Mes)Nacnac = {[(Mes)NC(Me)](2)CH}(-), Mes = 2,4,6-Me(3)C(6)H(2)].

211 t in the primary report (Krystal et al., Nat Med, 2020), the current findings suggest that further tr

212 )] (2) ((Me) L={(2,6-(i) Pr(2) C(6) H(3) )NC(Me)}(2) CH), was isolated via reaction of [(Me) LZnSCPh(

213 rystalline material [(Mes)Nacnac = {[(Mes)NC(Me)](2)CH}(-), Mes = 2,4,6-Me(3)C(6)H(2)].

214 S)L(Cl)Si -> Ni(NHC)(2); NHC = :C[( (i)Pr)NC(Me)](2)).

215 assigned as an Fe(IV)(O) complex, Fe(IV)(O)(Me(3)TACN)(S(2)SiMe(2)) (3), which was identified by UV-

216 min (NPM1) as an essential regulator of 2'-O-Me on rRNA by directly binding C/D box small nucleolar R

217 we link ribosomal RNA 2'-O-methylation (2'-O-Me) to the etiology of dyskeratosis congenita.

218 We demonstrate the importance of 2'-O-Me-regulated translation for cellular growth, differenti

219 acturonan I and 1,5-, 1,3,5-arabinan and 4-O-Me-glucuronoxylan polysaccharides.

220 observed in host-guest complex [NH(4)(+)C o-Me(2)-2.1.1], which spontaneously rearranged into the la

221 timal NH(4)(+) binding, complex [NH(4)(+)C o-Me(2)-2.2.1] was found to be thermodynamically stable (n

222 dynamically more stable complex [NH(4)(+)C o-Me(2)-2.2.1], even though this process led to the format

223 process led to the formation of poor host o-Me(2)-1.1.1 as a consequence of the excess of one subcom

224 astereoisomeric alcoholato complexes [Fe(OCH(Me)Ph)(CNCEt(3))(1)]BF(4) (10R and 10S).

225 Additionally, the R (p) diastereomer of Me-PTEs at XT sites and both diastereomers of Me-PTEs at

226 e-PTEs at XT sites and both diastereomers of Me-PTEs at TX sites exhibited error-free replication byp

227 (3)SiO group (followed by the elimination of Me(3)SiOH) and protonation of the thiophene ring in 2-ch

228 Preliminary investigations of p K(a)s of Me(10)Tu[3](2+) and an interaction of L-glutamine indica

229 n, by analogy to the known polymerization of Mes-P=CPh(2).

230 The thermally induced rearrangement of Mes*P=C=C(H)R' (R' = tBu, Ad) afforded by C-H activation

231 t begins with a Ni(2) -mediated coupling of (Me(3) Si)CHN(2) and the diene.

232 While one-electron reduction of ((Mes)dmx)Cu(2)(mu(2)-N(C(6)H(4)OMe)) with potassium graph

233 (Me)}(2) CH), was isolated via reaction of [(Me) LZnSCPh(3) ] (1) with 2.3 equivalents of KC(8) in TH

234 atom donors gives a new species, Fe(III)(OH)(Me(3)TACN)(S(2)SiMe(2)) (4).

235 r R,R'-BhPy(+) (R,R' = H,H'; Me,Me'; H,OMe'; Me,OMe'; OMe,OMe'; NPh(2),NPh(2)') predict that these io

236 t with nucleophiles, resulting in aryl-Ge or Me-Ge nucleophile-assisted fragmentations.

237 (6)H(3)-N=CMe)-C(5)H(4)N] where R = (i)Pr or Me, L(2) = bis-olefin), were characterized by single-cry

238 xyl radical 1-methyl-2-azaadamantane N-oxyl (Me-AZADO) exhibits magnetic bistability arising from a r

239 cyclic phosphonium salt [cyclo-{(Mes)P}(2) P(Mes)(2) ][BAr(F) (4) ].CyMe through the cyclisation of a

240 ved in adaptive response and repair of S (p)-Me-PTE in E. coli, however, was essential for the genera

241 n single-stranded vectors contained an S (p)-Me-PTE in the sequence contexts of 5'-AT-3', 5'-CT-3', o

242 ty of the 5' nucleotide adjacent to an S (p)-Me-PTE.

243 that Ada contributes to mutagenesis of S (p)-Me-PTEs in E. coli.

244 the ordered diamagnetic crystalline phase, (Me-AZADO)(2), has been conclusively demonstrated by crys

245 rovided unique "push-pull" phosphastannene ((Mes)Ter)(Ar)Sn = P(IDipp) (Ar = C(6)F(4)[B(F)(C(6)F(5))(

246 riles as monomeric tetrylene-phosphinidenes (Mes)TerEP(IDipp) (E = Ge, Sn; (Mes)Ter = 2,6-Mes(2)C(6)H

247 co), and one isolated indigenous population (Me'Phaa, Mexico).

248 isolated the nucleophilic addition product [(Me)(Ph)(CCHC){Au(IPr)}(2)(SOMe(2))]NTf(2) with DMSO.

249 search of electronic databases (Athens, Pub Med, Web of Science, Science Direct, AMED, CINAHL, Cochr

250 Overall, QD394 and QD394-Me represent novel ROS-inducing drug-like compounds warr

251 ptimization resulted in the derivative QD394-Me, which showed improved plasma stability and reduced t

252 The S(c) configured oxazoline moiety (R = Me, i-Pr) was used to control the generation of planar c

253 e of an acylium ion, [RGe(O)(NHC)(2)]X (R = (Mes)Ter = 2,6-(2,4,6-Me(3)C(6)H(2))(2)C(6)H(3); NHC = IM

254 rived from P-OP ligands L1, ent-L1, or (R,R)-Me-DuPHOS as catalysts has been successfully accomplishe

255 imide complexes ((R)dmx)Cu(2)(mu(2)-NAr) (R: Mes, (t)Bu; Ar: 4-MeOC(6)H(4), 3,5-(F(3)C)(2)C(6)H(3)) w

256 ations using the activated precatalysts rac-[Me(2) Si(indenyl)(2) ]ZrMe(2) and [Me(2) C(Cp)(fluorenyl

257 strong reductants like the Mg(I) reagent {((Mes)Nacnac)Mg}(2) (72% yield) or Na (52% yield) a phosph

258 ituted rhodium complex (eta(5)-C(5)Me(5))Rh((Me)PhI)H ((Me)PhI = N-methyl-1-phenylethan-1-imine) exhi

259 51.8 kcal mol(-1) for (eta(5)-C(5)Me(5))Rh((Me)PhI)H and 51.1 kcal mol(-1) for (eta(5)-C(5)Me(5))Rh(

260 Treatment of 1a.Fp(+) with [(Me(2) N)(3) S][Me(3) SiF(2) ] results in fluoride addition to the P-cen

261 ne radical 2(*) with the imidazolium salt [{(Me)CN(i-Pr)}(2)CH](+)[Cl](-) (in a 1:1 molar ratio) give

262 Reaction of same (Mes(2)BH)(2) with Bronsted acid also afforded the same d

263 cleating, pacman dipyrrin ligand scaffolds ((Mes)dmx, (tBu)dmx: dimethylxanthine-bridged, cofacial bi

264 scribed to prepare compounds R(2)P(X)C(S)SCH(Me)Ph with the P atom either in the oxidation state V [R

265 ly protonated to yield the [t-Bu(2)PHC(S)SCH(Me)Ph](+) cation (10-H(+)), which was isolated as a BF(4

266 ):716-722; Kim et al., J Gerontol A Biol Sci Med Sci.

267 J Gerontol A Biol Sci Med Sci.

268 osphinidenes (Mes)TerEP(IDipp) (E = Ge, Sn; (Mes)Ter = 2,6-Mes(2)C(6)H(3), IDipp = C([N-(2,6-iPr(2)C(

269 Use of a silyl supported stannylene ((Mes) TerSn(Si(t) Bu(3) ) [(Mes) Ter=2,6-(2,4,6-Me(3) C(6

270 boryl complexes of calcium and strontium, {(Me(3) Si)(2) N}M{B(NDippCH)(2) }(thf)(n) (M=Ca, n=2; M=S

271 he corresponding trimethylsilyl-substituted (Me(3)Si)(2)Si(5)R(4).

272 In summary, Me-iPLEX is an elegant method to assess epigenetic signa

273 al methylation of aromatic acids using TEMPO-Me.

274 e(2)SPM administration to mice revealed that Me(2)SPM significantly decreases spermidine levels in mu

275 We found that (Me(4)N)(2)[Cd(4)(SPh)(10)] is indeed a very strong quenc

276 into strips lined with methyl groups of the Me(2)pyzH(+) cations and strips featuring extensive hydr

277 otonation of oxygen in the side chain of the Me(3)SiO group (followed by the elimination of Me(3)SiOH

278 tural distortions, whereas BDPA-5Me with the Me group close to the anthracene backbone experiences se

279 By using the (Me)IMesCu-FeCp(CO)(2) catalyst, a variety of alpha-vinyl

280 , key to formation of [Cs(crypt-222)][(TIMEN(Mes))Fe(NO)], (5) featuring a metalacyclic [Fe-(NO-NHC)(

281 mesitylimidazol-2-ylidene)ethyl]amine (TIMEN(Mes)), which is known to support iron in high and low ox

282 a oxygenation of the nitride complex [(TIMEN(Mes))Fe(N)](BF(4)).

283 tter protocol provides facile access also to Me(2)Si(H)Cl, a most important silicone building block.

284 ed the oxidative addition of aryl iodides to Me-DalphosAu(+) for the formation of a Au(III) -Ar inter

285 ing from C-H bond activation of toluene, [{((Me(3)Si)(2)N)(2)U(THF)}(2)(mu-N)][{((Me(3)Si)(2)N)(3)U(m

286 Using Me(10)Fc(+), a 1 2 equilibrium was established, allowing

287 lopropanation reactions of 1,3-dienes using (Me(3) Si)CHN(2) .

288 hotosensitizer, Zr((Mes)PDP(Ph))(2), where [(Mes)PDP(Ph)](2-) is the doubly deprotonated form of [2,6

289 methylation in marine waters and explain why Me(2)Hg is a significant Hg species in oceans but seemin

290 We find that BDPA-2Me, with Me groups adjacent to the pyridyl N, has the longest B-N

291 romo-5,5',6,6'-tetraol (Br(4)spiroH(4)) with Me(n)tpa ancillary ligands (tpa = tris(2-pyridylmethyl)a

292 series of BN-fused dipyridylanthracenes with Me groups in different positions of the pyridyl ring hav

293 norbornadienone derivatives by reaction with Me(3)SnLi.

294 Treatment with Me(3)SiCl affords the corresponding trimethylsilyl-subst

295 of radicals derived from phosphasilenes with Mes, Tip, Dur, and NMe(2) substituents on the P atom, us

296 y introduced through the reaction of 2 with (Me(3)Si)(2)NR' or 5 with H(2)NR' or H(2)O (R' = H, Me, p

297 Treatment of 1a.Fp(+) with [(Me(2) N)(3) S][Me(3) SiF(2) ] results in fluoride additi

298 mple of silatranes XSi(OCH(2)CH(2))(3)N (X = Me, H, F, Cl), XS, it was found that the effect of the d

299 Zr((Mes)PDP(Ph))(2) engages in numerous photoredox catalytic

300 light-absorbing Zr(IV) photosensitizer, Zr((Mes)PDP(Ph))(2), where [(Mes)PDP(Ph)](2-) is the doubly