ライフサイエンスコーパス: Michael addition

1 tive ligands for asymmetric copper-catalyzed Michael addition.

2 r nucleophiles such as cysteine thiolates by Michael addition.

3 eochemical outcome of a catalyzed asymmetric Michael addition.

4 of these catalysts for enantioselective aza-Michael addition.

5 which then react with cysteine residues via Michael addition.

6 on step via a Diels-Alder cycloaddition or a Michael addition.

7 a substituted hydroquinone by reductive 1,4-Michael addition.

8 and covalently bind PPARgamma at Cys-285 via Michael addition.

9 A by redox cycling and/or depurination via a Michael addition.

10 ably due to the less steric hindrance in the Michael addition.

11 the three His residues in Abeta proteins by Michael addition.

12 s, the N-nitroso aldol reaction, followed by Michael addition.

13 ed to glutathione conjugates (LNO(2)-SG) via Michael addition.

14 vity, due to intramolecular catalysis of the Michael addition.

15 tion proves that the reaction occurs through Michael addition.

16 ex mixtures via a Strecker-like synthesis or Michael addition.

17 y a final intramolecular amine-catalyzed oxa-Michael addition.

18 late-stage, highly diastereoselective, sulfa-Michael addition.

19 into tricyclic compounds via intramolecular Michael addition.

20 facilitates enantioselective, intramolecular Michael additions.

21 dehyde using DABCO at room temperature via a Michael addition, 5-exo-dig carboannulation, and oxidati

22 furans is developed via DBU-mediated tandem Michael addition/5-exo-dig-cycloisomerization of enynes

23 proceeds via a cascade reaction involving a Michael addition-6pi-electrocyclic ring opening-proton t

24 lenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant i

25 of five fragments through a stereoselective Michael addition, a three-component nitro-Mannich lactam

26 Only Bar-Me forms a Michael addition adduct with glutathione (GSH) and inhib

27 Mass spectrometry identified Michael addition adducts of 4-HNE on Cys(130), Cys(174),

28 cts with aS via formation of Schiff-base and Michael-addition adducts with Lys residues, in addition

29 y a stepwise (4 + 2) cycloaddition involving Michael addition, aldol cyclization, and lactonization.

30 (aryl)-S coupling, thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reacti

31 igands relying on an organocatalytic one-pot Michael addition-aldol reaction with cheap 2-cyclohexeno

32 so typical that many have proper names (e.g. Michael addition, Amadori rearrangement, and Pictet-Spen

33 A subsequent stereoselective aza-Michael addition and an intramolecular Heck-type reactio

34 s the cascade transformation based on double Michael addition and aromatization (retro-Claisen cleava

35 es, proteins, and oligonucleotides employing Michael addition and Diels-Alder cycloaddition reactions

36 N2' substitution, intramolecular 6-endo-trig Michael addition and double elimination.

37 rocyclic core, followed by an intramolecular Michael addition and oxidative radical cyclization to ac

38 ne-3,7-dione scaffolds was synthesized via a Michael addition and reductive cyclization strategy.

39 ers of laurenditerpenol involving sequential Michael addition and remote homoallylic hydroxyl group-d

40 This protocol involves Michael addition and subsequent carbonylation.

41 in metathesis, Heck coupling, hydroarylation Michael addition and tandem coupling.

42 sion is provided for both the intramolecular Michael addition and the sulfone rearrangement.

43 ir susceptibility to other reactions such as Michael additions and the difficulty of controlling the

44 eacted with GSH to form GS-hydroquinones via Michael addition, and four GS-HQRs from yeast and bacter

45 benzoquinones reacting with reduced GSH via Michael addition, and GS-HQRs convert the conjugates to

46 o different reagents to yield cycloaddition, Michael addition, and other reactions at double bonds.

47 ycloaddition, 1,3-sigmatropic rearrangement, Michael addition, and Pictet-Spengler reaction among oth

48 ed CBS reduction, Achmatowicz rearrangement, Michael addition, and reductive amination as key steps.

49 e reactions including Michael additions, aza-Michael additions, and direct Aldol reactions.

50 a-amino ester)s (HPAEs) via a new "A2+B3+C2" Michael addition approach demonstrating 2 to 126-fold hi

51 al theory (DFT), investigating the different Michael-addition approaches of the sulfur ylide, the tra

52 Although adducts formed by Michael addition are thought to be largely irreversible,

53 releasing methods, such as beta-elimination/Michael addition, are not specific to O-glycan release a

54 operative hydrogen bonding/enamine-catalyzed Michael addition as the key step.

55 e first domino reaction, two consecutive aza-Michael additions assemble the six-membered ring heteroc

56 mechanistically diverse reactions including Michael additions, aza-Michael additions, and direct Ald

57 njunction with alkaline beta-elimination and Michael addition (BEMA) reactions for the specific detec

58 The usage of a diastereoselective oxy-Michael addition/benzylidene acetal formation coupled wi

59 nic transition state and intermediate of the Michael addition, but less intuitively, it destabilizes

60 11-keto group in CF3DODA-Me, which prevents Michael addition by the conjugated en-one in the A-ring.

61 y a dynamic kinetic (DyKat) ketalization/oxa-Michael addition cascade using cinchona alkaloid-based c

62 ton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)(2) comp

63 An asymmetric Michael addition, CBS reduction, and proline-catalyzed c

64 odified through beta elimination followed by Michael addition chemistry to install a photolabile grou

65 with naphthalenethiol using well established Michael Addition chemistry.

66 to be a similar if not superior catalyst for Michael additions compared with typical Lewis acids.

67 Pivoting on a two-stage catalytic Michael addition/condensation strategy, the use of an al

68 nd alpha-hydrazinonitroalkenes via a cascade Michael addition-cyclization protocol to afford nitrodih

69 Enantioselective Michael addition-cyclization reactions using different a

70 l Knoevenagel condensation/enamine formation/Michael addition/cyclization sequence is highlighted by

71 Lewis acids affect these one-pot aza-Michael-addition/cyclization/dehydration reaction sequen

72 The multicascade process involves Michael addition, Dieckmann cyclization, and a series of

73 The process relies on a tandem double Michael addition-Dieckmann condensation reaction, which

74 This strategy, which involves a cascade Michael addition-Dieckmann cyclization-elimination seque

75 efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to 99%) in high chem

76 ates that there is a rate enhancement of the Michael addition due to the urea groups on the surface o

77 que carrier system is fabricated using a new Michael addition during (water-in-oil) emulsion (MADE) m

78 Using an improved maleimide-thiol based Michael Addition during (water-in-oil) Emulsion (MADE) m

79 An asymmetric doubly vinylogous Michael addition (DVMA) of alpha,beta-unsaturated gamma-

80 report a new dynamic polymerization based on Michael addition-elimination reaction of structurally di

81 (ii) installation of the amino group via aza-Michael addition/elimination, and crucially (iii) facile

82 isms of known aminotransferase inactivators: Michael addition, enamine addition, and fluoride ion eli

83 process involves a secondary amine catalyzed Michael addition followed by a N-heterocyclic carbene ca

84 on hydrolysis in one pot, an intramolecular Michael addition followed by a retro-Michael-type elimin

85 this 3 + 2 annulation involved a vinylogous Michael addition followed by an intramolecular enamine a

86 The cascade proceeds via amine-mediated Michael addition followed by an N-heterocyclic carbene-p

87 n of benzoyl-substituted indolizines through Michael addition followed by C-N bond formation, which a

88 Products are formed by the aza-Michael addition followed by intramolecular acyl substit

89 f 1,3-syn-diols via an intramolecular hetero-Michael addition followed by reductive deprotection of t

90 The reaction proceeds through a Michael addition followed by ring expansion of methylene

91 Intramolecular Michael addition follows to give either N-aminoisoindolo

92 el formulation that uses thiol-vinyl sulfone Michael addition for crosslinking.

93 The route to (-)-1 is based on a double Michael addition for the formation of the bridged diazad

94 oncerted Diels-Alder reaction and a stepwise Michael addition, for the formation of corresponding pro

95 A tandem phenol oxidation-Michael addition furnishing oxo- and -aza-heterocycles h

96 Michael addition has been achieved with a variety of ami

97 as a traceless activation group for radical Michael additions has been accomplished via visible ligh

98 ing and arylating nucleophilic substrates by Michael addition, has been extensively studied as a mode

99 N-heterocyclic carbene catalyzed Michael additions have been revisited with 1,3-dialkyl-

100 dergo Bronsted acid catalyzed intramolecular Michael addition in one-pot to produce oxo- and -aza-het

101 ive recoverable organocatalysts in different Michael additions, in neat conditions at room temperatur

102 at target nine nucleophilic residues through Michael addition, including Gln, Arg, and Asn, which are

103 d reaction progressed via enamine formation, Michael addition, intramolecular cyclization, and intram

104 n-intramolecular S(N)Ar reaction or a tandem Michael addition-intramolecular Ad(N)E process to furnis

105 ensation-Michael addition-intramolecular oxa-Michael addition-intramolecular aldol reactions.

106 involved sequential Knoevenagel condensation-Michael addition-intramolecular oxa-Michael addition-int

107 nsformations proceed through either a tandem Michael addition-intramolecular S(N)Ar reaction or a tan

108 socyanide zwitterionic intermediates through Michael addition/intramolecular cyclization and double [

109 s is described, which includes base-mediated Michael addition/intramolecular cyclization/[1,5]-H shif

110 lytic [3 + 3] annulation strategy based on a Michael addition/intramolecular Julia-Kocienski olefinat

111 Michael addition is a premier synthetic method for carbo

112 n organocatalyzed, intramolecular heteroatom Michael addition is described.

113 t of stereoselectivity as that seen when the Michael addition is performed at very low temperatures.

114 rmore, an important feature of 1 is that its Michael addition is reversible.

115 regioselective N-arylation, followed by aza-Michael addition, is disclosed using 2-aminobenzothiazol

116 talyzed and highly diastereoselective direct Michael addition-isomerization sequence is presented for

117 An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords

118 This process proceeds by intermolecular Michael addition/lactamization, thiophenol elimination,

119 otes the catalytic asymmetric intramolecular Michael addition-lactonization of a variety of enone aci

120 mote the catalytic asymmetric intermolecular Michael addition-lactonization of arylacetic acids and a

121 reaction channel involves an intramolecular Michael addition leading to the experimentally observed

122 ween enzyme and isomerized 5-FU we propose a Michael addition mechanism for pseudouridine formation t

123 es revealed that aromatization competes with Michael addition mechanism in the presence of 5-amino-2-

124 hosphonate (PAA-BP) was synthesized by using Michael addition methodology.

125 from 4-methyleneisoxazol-5-ones via "cyanide Michael addition/methylation/reductive isoxazole-pyrrole

126 cisely on a gram scale through an asymmetric Michael addition, nitro-Mannich/lactamisation, Tsuji-Tro

127 -1,2-diamine]Br(2) was shown to catalyze the Michael addition of 1,3-dicarbonyl compounds to nitroalk

128 example of an asymmetric aminocatalyzed aza-Michael addition of 1H-indazole derivatives to alpha,bet

129 succinimides was realized via the vinylogous Michael addition of 3-substituted cyclohexenones to N-(2

130 tions as pivotal steps: 1) an intramolecular Michael addition of a benzyloxycarbonyl-protected lactam

131 limination of the phosphorylated group, (ii) Michael addition of a bifunctional group, and then (iii)

132 conveniently synthesized via selective thia-Michael addition of a commercially available methacrylat

133 rphenyls were synthesized in good yields, by Michael addition of a conjugate base of core-substituted

134 readily prepared by phase-transfer-catalyzed Michael addition of a glycine Schiff base to a variety o

135 ence include organocatalytic, intramolecular Michael addition of a keto sulfone and a tandem 1,3-sulf

136 It is found that the Michael addition of a range of enolizable carbonyl compo

137 urea was used to trigger the base-catalyzed Michael addition of a water-soluble trithiol to a polyet

138 Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene catalyzed

139 novel strategy for the catalytic asymmetric Michael addition of aldehydes to nitroolefins on water h

140 The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated alpha-su

141 ine was accomplished in three steps: (1) aza-Michael addition of allylamine to tricarbonyl(tropone)ir

142 mine promotes an accompanying base-catalyzed Michael addition of alpha1(I) H932 imidazole to the alph

143 The key step involves organocatalytic Michael addition of an aldehyde to 1-nitrocyclohexene.

144 igh yield and exquisite stereoselectivity by Michael addition of an enantioenriched hydroazulenone en

145 otopically labeled acetyl-alanine; (3) thiol Michael addition of an isotopically labeled acetyl-cyste

146 Stereoselective sulfa-Michael addition of appropriately protected thiocarbohyd

147 An isothiourea-catalyzed enantioselective Michael addition of aryl ester pronucleophiles to vinyl

148 ride/p-toluenesulfonic acid-water in the aza-Michael addition of arylamines to maleimide to obtain am

149 A new practical method for the asymmetric Michael addition of arylboronic acids to alpha,beta-unsa

150 Complexes 4 and 9 were found to catalyze the Michael addition of benzyl cyanide derivatives to alpha,

151 aries, we report the direct enantioselective Michael addition of carboxylic acids.

152 The Michael addition of deoxyguanosine to HNE yields four di

153 Michael addition of di-tert-butyl methylenemalonate to t

154 er key reactions in the synthesis involved a Michael addition of dimethyl malonate on cyclohexadienon

155 asily accessed via a highly enantioselective Michael addition of dimethyl malonate to a nitrostyrene,

156 A mild protocol for the asymmetric Michael addition of dimethyl malonate to various alpha,b

157 e microgels is achieved via the nucleophilic Michael addition of dithiolated PEG macro-cross-linkers

158 nomers were prepared via the highly reliable Michael addition of ethenesulfonyl fluoride and amines/a

159 The Michael addition of free amino acids to acrylamide was f

160 to interrogate the rate-limiting step of the Michael addition of glycinate imines to benzyl acrylate

161 a glutathiylated conjugated quinone and (ii) Michael addition of GSH to the quinone, a 2-electron red

162 were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, off

163 The asymmetric Michael addition of ketones to allylidene malonates was

164 , which implies a sequential organocatalyzed Michael addition of ketones to enals, followed by cataly

165 n, butenolide formation, and spontaneous oxa-Michael addition of MeOH.

166 In a cascade event, initial Michael addition of NaNO2 to the MBH acetate furnishes t

167 An efficient and highly enantioselective Michael addition of nitroalkanes to 3-ylidene oxindoles

168 r the enantioselective isothiourea-catalyzed Michael addition of nitroalkanes to alpha,beta-unsaturat

169 t cinchona thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones.

170 ynthesized, and evaluated for the asymmetric Michael addition of nitroalkanes to nitroalkenes.

171 butanol in turn is prepared in two steps via Michael addition of nitromethane to acrylate followed by

172 tron rich and electron poor enones underwent Michael addition of nitrophosphonates to afford the quat

173 The strategy exploits hitherto unknown Michael addition of PH-containing compounds (diphenylpho

174 The Michael addition of phosphorus nucleophiles is postulate

175 Michael addition of phosphorus nucleophiles to the unsym

176 tional study and kinetic analysis of the aza-Michael addition of primary and secondary amines to acry

177 The asymmetric oxa-Michael addition of salicylaldehyde to conjugated nitroa

178 A totally stereocontrolled C-Michael addition of serine-equivalent C-nucleophiles to

179 The method is based on an oxidative Michael addition of suitable indoles on the double bond

180 n subject of this paper, features a one-step Michael addition of t-butyl 2-((diphenylmethylene)amino)

181 Enantioselective Michael addition of tertiary alpha-nitroesters to beta-u

182 y profiles from DFT calculations suggest the Michael addition of the 1,3-dipole to be the rate- and e

183 -directed and irreversible, resulting from a Michael addition of the active-site Cys Sgamma onto the

184 Evidence suggests that Michael addition of the benzylic anion derived from a gi

185 Michael addition of the deprotonated aminonitriles to th

186 Michael addition of the deprotonated tosylamides to the

187 The aza-Michael addition of the in situ formed enamine, generate

188 This inhibition was due to a Michael addition of the penultimate selenocysteine resid

189 ing of the 3-aroylbenzofurans and subsequent Michael addition of the resulting 1,3-dicarbonyl interme

190 Michael addition of thiourea to enones with subsequent i

191 chael donors, intermediates arising from the Michael addition of unsaturated beta-ketoesters to alpha

192 o EA-tuned peptides via beta-elimination and Michael addition of various thiol compounds.

193 for elimination of homocysteine, followed by Michael addition of water to the resulting intermediate

194 k at C-3 of 3-chloropropiolate to initiate a Michael addition of water.

195 Enantioselective Michael additions of 4-hydroxycoumarin to beta-nitrostyr

196 n A has been developed employing consecutive Michael additions of a 4-hydroxypyrone to a sorbicillino

197 his catalyst effectively promotes asymmetric Michael additions of aldehydes to challenging but biolog

198 on of acetylenic dienophiles with subsequent Michael additions of aromatic ketones to install a chrom

199 natural amino acids and catalyze asymmetric Michael additions of ketones to nitroalkenes.

200 SN(Ar) displacement reaction and subsequent Michael addition onto acrylate leads to the formation of

201 d transformations proceed via intramolecular Michael addition or activation of the enone moiety pathw

202 ly long-lived that they can damage DNA via a Michael addition or by redox cycling.

203 ve stability and operate via a complementary Michael addition-pathway upon enzymatic oxidation of the

204 vel diastereoselective, intramolecular amide Michael addition process.

205 enium-supplemented cells correlated with the Michael addition product of 15d-PGJ2 with Cys-179 of IKK

206 with up to six HNE molecules incorporated as Michael addition products.

207 ates in multiple pathways, including further Michael addition, proton abstraction, and catalyst deact

208 An intermolecular Michael addition reaction and an intramolecular condensa

209 lear that a good understanding of the hetero-Michael addition reaction and the relative reactivities

210 ides are cyclized through a proximity-driven Michael addition reaction between a cysteine and an ambe

211 Bis-cinchona catalyst 3b activates the Michael addition reaction between malononitrile derivati

212 As an example the organocatalysed Michael addition reaction between nitrostyrene and 3-met

213 A reversible Michael addition reaction between thiol nucleophiles and

214 The mechanism of the enantioselective sulfa-Michael addition reaction catalyzed by a cinchona alkalo

215 Study of the intramolecular aza-Michael addition reaction from an aminofluorovinylsulfon

216 loro ketone can be efficiently combined to a Michael addition reaction in a new two-step domino react

217 he PPARgamma ligand binding domain through a Michael addition reaction involving a protein cysteine r

218 ared and screened as organocatalysts for the Michael addition reaction of aldehydes with beta-nitroal

219 center has been developed via a tandem thio-Michael addition reaction of an in situ generated alpha,

220 his manuscript, a simple and efficient sulfa-Michael addition reaction of aryl thiols to trisubstitut

221 An efficient Michael addition reaction of differently substituted eno

222 ration of 1 was confirmed by thiol-selective Michael addition reaction of immunoprecipitated CD43-myc

223 The first example of a catalytic Michael addition reaction of non-activated aliphatic nit

224 An intramolecular FeCl3-catalyzed Michael addition reaction of styrene, a poor nucleophile

225 (2-succinyl)cysteine (2SC) is formed by a Michael addition reaction of the Krebs cycle intermediat

226 enolate that will undergo an intramolecular Michael addition reaction to form two new stereogenic ce

227 generated p-quinone imine participates in a Michael addition reaction with 2-SH-benzazoles leading t

228 bond to cysteine-316 in alpha-tubulin via a Michael addition reaction.

229 id (LNO2) rapidly react with GSH and Cys via Michael addition reaction.

230 orm for anchoring chemical functions via the Michael addition reaction; and (iii) PDOPA was used as a

231 es containing a cis-enone are susceptible to Michael addition reactions and are potent inhibitors of

232 cular vessel has been utilized for catalytic Michael addition reactions of a series of nitrostyrene d

233 simple, bioinspired synthetic cage catalyzes Michael addition reactions using only Coulombic and othe

234 heir catalytic performance in representative Michael addition reactions was used in an effort to comp

235 beta to the nitro group, thus competent for Michael addition reactions with cysteine and histidine.

236 Such reactive aldehydes are subject to Michael addition reactions with the side chains of lysin

237 nation of Se-alkylselenocysteine followed by Michael addition reactions with various thiol nucleophil

238 ne or cinchona alkaloid-urea catalyzed sulfa-Michael addition reactions, also applies to the catalyti

239 of condensation, Mannich, oxidation, and aza-Michael addition reactions, employing a variety of funct

240 ciency and expanding the generality of these Michael addition reactions.

241 (3)-catalyzed [4 + 1]-cycloaddition with aza-Michael addition reactions.

242 base-induced tandem beta-elimination/hetero-Michael addition rearrangement of (E)-N-benzoylethylpyri

243 to a cascade of reactions, namely oxidation, Michael addition, reduction, acetylation, and cycloconde

244 l Diels-Alder cycloaddition or a competitive Michael addition/reduction to access aspidosperma-type a

245 ones through a transition-metal-free, tandem Michael addition-S(N)Ar process is delineated.

246 ynthesis involves a Knoevenagel condensation/Michael addition sequence, followed by the formation of

247 stries are thiol-disulfide exchange and thio-Michael addition, sharing the thiol as the common buildi

248 he reaction involves a tandem pathway of aza-Michael addition, SN2, and a unique redox-neutral proces

249 e N or S heteronucleophile to give the first Michael addition step affording regioselective substitut

250 s of all reactants; (ii) a turnover-limiting Michael addition step, (iii) product inhibition, (iv) th

251 -derived bifunctional organocatalyst for the Michael addition step.

252 The thiol-Michael addition (TMA) is a powerful methodology to clic

253 hrough use of an organocatalyzed, heteroatom Michael addition to access a common intermediate.

254 ped a conjugation reaction based on the thia-Michael addition to activated triple bonds, which can be

255 sequential activation initiated by a hetero-Michael addition to alpha,beta-unsaturated aldehydes aff

256 The products of the organocatalytic sulfa-Michael addition to alpha,beta-unsaturated alpha-amino a

257 e converted to the desired pseudopeptides by Michael addition to alpha-methyleneglutarate esters.

258 were investigated to control a keto sulfone Michael addition to construct the C7-C12 linkage.

259 The synthesis utilizes Michael addition to create a branch point at the end of

260 In addition, a Michael addition to dimethoxy cyclohexadienones was stud

261 at for primary and secondary amines, the aza-Michael addition to ethyl acrylate occurs preferentially

262 of the thiazole ring and intramolecular aza-Michael addition to furnish the title products.

263 lic reactivity of KETE-PEs is shown by their Michael addition to glutathione and cysteine.

264 number of key steps, including an asymmetric Michael addition to install the C4'-C3'-C7' stereotriad,

265 An unprecedented catalytic aza-Michael addition to substituted 3-vinyl-1,2,4-triazines,

266 e showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates.

267 ctive umpolung synthons for enantioselective Michael addition to substituted enones.

268 ivative in that the reaction is initiated by Michael addition to the beta-carbon atom of the alpha,be

269 n by 1 involving amine oxidation followed by Michael addition to the propargylic imine.

270 t strongly disfavors a mechanism involving a Michael addition to the pyrimidine ring.

271 t that the reaction sequence is initiated by Michael addition to the side chain enone.

272 and anti-inflammatory effects via reversible Michael addition to thiol-containing proteins in key sig

273 n ONIOM(QM/MM) study on the mechanism of the Michael addition to triple bonds catalyzed by chiral dii

274 Sulfa-Michael additions to alpha,beta-unsaturated N-acylated o

275 experiments establish the relative rates of Michael additions to be in the following order: Et>i-Pr>

276 nt, one-pot domino process through a 1,6-aza-Michael addition-triggered sequence and an original Mits

277 pid peptide and protein conjugates formed by Michael addition-type conjugation reactions of alpha,bet

278 ction with a diastereoselective nitro olefin Michael addition under bifunctional organocatalysis and

279 this annulation are alkyne insertion and aza-Michael addition under oxidant-free mild reaction condit

280 These reagents undergo rapid thiol Michael-addition under biocompatible conditions in stoic

281 ctivity, including both C- and O-alkylation, Michael addition via C-5 to an acetylenic ester, tetrach

282 beta-position through a putative reversible Michael addition was observed.

283 n stereoselectivity and reaction rate in the Michael addition was observed.

284 The remarkable diastereoselectivity of the Michael addition was specifically demonstrated with diff

285 ications: First, a fast exothermic reaction (Michael addition) was monitored with backscattering fibe

286 Amide coupling and thiol-ene Michael addition were found to be ineffective for the sy

287 ber of efficient carba-, sulfa-, and phospha-Michael additions were achieved very conveniently, witho

288 nctionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using two-p

289 e products undergo reversible intramolecular Michael addition, which protects the monoalkenylated pro

290 e crystallographic observation of reversible Michael addition with a potent cyanoenone drug candidate

291 de; the resulting hemithioacetal undergoes a Michael addition with an adjacent unsaturated acrylate e

292 Quinolacetic acid reacts readily by Michael addition with cellular thiols to form a two-elec

293 or 196 Da from this peptide, and subsequent Michael addition with cysteamine increased masses by the

294 egradation and beta-elimination, followed by Michael addition with dithiothreitol (BEMAD).

295 tography/mass spectrometry that they undergo Michael addition with GSH.

296 , the trapping of the enolate resulting from Michael addition with prochiral electrophiles, such as a

297 Using a refined beta-elimination/Michael addition with tandem mass tags (TMT)-labeling pr

298 then undergo a rapid and chemoselective 1,4-Michael addition with the pKa-perturbed Lys-15 epsilon-a

299 It is known to undergo Michael additions with biological sulfur nucleophiles.

300 to be a superior glycine derivative for the Michael additions with various (R)- or (S)-N-(E-enoyl)-4