ライフサイエンスコーパス: NBI

1 NBI 35965 (10 mg/kg) administered p.o. or subcutaneously

2 NBI 35965 (20 mg/kg s.c.) significantly reduced the defe

3 NBI 35965 accelerated (125)I-astressin dissociation and

4 NBI 35965 administered per orally (p.o.) in rats (1, 3,

5 NBI 35965 did not completely inhibit (125)I-sauvagine bi

6 NBI did not result in better detection of adenomas by an

7 NBI endoscopy may represent a significant improvement ov

8 NBI with ME was the ideal screening tool (sensitivity, s

9 NBI-12i is a recently developed small molecule MC4-R ant

10 NBI-27914 (100 microg/rat) injected peripherally did not

11 NBI-35965 (10 mg/kg, iv) prevented the 2nd CRD- and ic C

12 NBI-5788-reactive T-cell lines generated from NBI-5788-t

13 NBI-750142 was estimated to achieve 36-78% VMAT2 target

14 NBI-921352 (formerly XEN901) is a novel sodium channel i

15 NBI-921352 is a potent inhibitor of Na(V)1.6 (IC(50)0.05

16 NBI-921352 is entering phase II proof-of-concept trials

17 NBI-921352 was effective in preventing seizures at lower

18 NBI-921352 waswell tolerated at higher multiples of the

19 NBI-921352is a state-dependent inhibitor, preferentially

20 NBI-ME surveillance of esophagus should be done in newly

21 p henyl)-6-methylpyrimidin-2,4-dione (R-13b, NBI 42902) displayed subnanomolar binding affinity (K(i)

22 P < - 2.25, DBI break > 11.5, NBI blur > 15, NBI break > 17.5, NBI recovery > 13, NPC < 5.75), and bo

23 onpeptide antagonists antalarmin, NBI 27914, NBI 35965, and DMP-696 only partially inhibited (125)I-a

24 ual comfort (DLP < - 2.25, DBI break > 11.5, NBI blur > 15, NBI break > 17.5, NBI recovery > 13, NPC

25 eak > 11.5, NBI blur > 15, NBI break > 17.5, NBI recovery > 13, NPC < 5.75), and body balance (NFD_H

26 ons at residues 16 and 19 (16Y-->A, 19C-->A; NBI-6024) was further characterized for its therapeutic

27 ults indicate that systemically administered NBI-80713 dose-dependently decreased heroin self-adminis

28 tween structure and CRF(1) binding affinity, NBI 35965 (12a) was identified as a high-affinity antago

29 ks' gestational age (GA) hospitalized for an NBI in the first 28 days of life in metropolitan France.

30 developed and established the validity of an NBI classification system that can be used to diagnose c

31 ition by the chemical antagonists AMG487 and NBI-74330 also reduced osteoclast recruitment and protec

32 o[2,3-d]pyrimidin-4-y l]amino-1-butanol, and NBI-27914 at doses (30 mg/kg, i.p.) that did not alter n

33 ed structure containing two basic groups and NBI-74330 [(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydr

34 that of mUcn 2, while the CRF(1) antagonist NBI-35965 had no effect.

35 enge and treatment with the CRFR1 antagonist NBI-27914 revealed a decreased respiratory exchange rati

36 vel water-soluble tricyclic CRF1 antagonist, NBI 35965 was developed that displayed a high affinity f

37 ceived DR infusions of the CRFr1 antagonist, NBI 35965, or CRF and were evaluated for stress responsi

38 The CRF receptor 1 (CRF-R1) antagonist, NBI-27914 (50-100 microg/rat) injected i.c.v., abolished

39 xamined the effects of a HCRT-R2 antagonist, NBI-80713, on heroin self-administration in rats allowed

40 he water-soluble CRF(1) receptor antagonist, NBI-35965.

41 n of the CRF1 receptor selective antagonist, NBI 35965.

42 R state, nonpeptide antagonists antalarmin, NBI 27914, NBI 35965, and DMP-696 only partially inhibit

43 lar masses of 210, 190, and 160 kD, and anti-NBI-1 and anti-NBI-2 specifically recognize 190-kD alpha

44 1A subunits recognized by anti-CNA3 and anti-NBI-2 are associated with syntaxin in a stable, SDS-resi

45 10, 190, and 160 kD, and anti-NBI-1 and anti-NBI-2 specifically recognize 190-kD alpha 1A polypeptide

46 CNA3) and for rabbit BI (anti-NBI-1 and anti-NBI-2) isoforms of alpha 1A.

47 rat rbA (anti-CNA3) and for rabbit BI (anti-NBI-1 and anti-NBI-2) isoforms of alpha 1A.

48 In rabbit brain, anti-NBI-1 or anti-NBI-2 specifically detect alpha 1A polypep

49 eal that calcium channels recognized by anti-NBI-2 are localized predominantly in dendrites and nerve

50 In rabbit brain, anti-NBI-1 or anti-NBI-2 specifically detect alpha 1A polypeptides with app

51 VIIC (Kd approximately 100 pM), whereas anti-NBI-2 immunoprecipitates two distinct affinity receptor

52 ur clinical candidate TAK-041, also known as NBI-1065846 (compound 56).

53 sponse to i.c.v. CRF and stress similarly as NBI-27914 injected i.c.v. at 100 microg/rat.

54 elationship was used to estimate VMAT2%TO at NBI-98782 exposures associated with valbenazine therapeu

55 n community practice must be achieved before NBI-based optical biopsy methods can be used routinely t

56 gly electron-accepting naphthalene bisimide (NBI) derivative functionalized with a new environmentall

57 of the CRH receptor type 1 (CRFR(1)) blocker NBI 30775 directly into the brain prevented the stress-i

58 retreatment with the selective CRF1 blocker (NBI 27914) increased the latency and decreased the durat

59 duced visceral hyperalgesia was abolished by NBI 35965 (20 mg/kg, s.c.).

60 y standard white light endoscopy followed by NBI.

61 Higher grades of dysplasia were found by NBI in 12 patients (18%), compared with no cases (0%) in

62 The features seen only by NBI were compared between GERD patients and controls.

63 1h restraint stress were antagonized only by NBI-35965 while stimulation induced by mUcn 2 was equall

64 and reliability of histologic prediction by NBI-experienced colonoscopists; (2) development of a cla

65 ) validation of the classification system by NBI-trained gastroenterology fellows, using still images

66 -induced delayed gastric emptying while i.c. NBI-27914 (50 or 100 microg) had no effect.

67 acteristics were similar in the two cohorts: NBI-HD-WLE (n = 21) and HD-WLE-NBI (n = 20).

68 recommendations informed by high-confidence NBI analysis of diminutive polyps and results from histo

69 g semifluorinated groups and the dendronized NBI with m = 1 and 2 self-organize into lamellar crystal

70 The dendronized NBI with m = 3 self-assembles into an unprecedentedly co

71 At the highest doses, NBI 35965 completely prevented [125I]sauvagine labeling

72 ated for Barrett's esophagus with dysplasia, NBI detected significantly more patients with dysplasia

73 For NBI, overall sensitivity was 91.0% (95% CI 88.6-93.0), s

74 BI-5788-reactive T-cell lines generated from NBI-5788-treated patients exhibited an increased frequen

75 secretion by APL-reactive T-cell lines from NBI-5788-treated MS patients was more frequently T-helpe

76 Furthermore, NBI-12i-treated uremic mice gained lean body mass, fat m

77 ed binding (by 13-40%) and accelerated [(3)H]NBI 35965 dissociation.

78 at the R state were demonstrated using [(3)H]NBI 35965: agonist peptides only partially inhibited bin

79 describe a custom-built nesting box imager (NBI) that uses a single-board computer (Raspberry Pi) wi

80 Narrow-band imaging (NBI) allows real-time histologic classification of color

81 analysis of polyps with narrow band imaging (NBI) by community-based gastroenterologists.

82 It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-

83 Narrow band imaging (NBI) endoscopy system enhances visualization of microvas

84 solution endoscopy with narrow band imaging (NBI) enhances the visualization of mucosal glandular and

85 Narrow band imaging (NBI) might highlight adenomas and lead to higher rates o

86 th white-light imaging, narrow-band imaging (NBI) with magnifying endoscopy (ME), and chromoendoscopy

87 t colonoscopy (WLC) and narrow-band imaging (NBI), does not have sufficient accuracy to assess the in

88 IEE) techniques such as narrow-band imaging (NBI), linked color imaging (LCI) and blue laser imaging

89 he validity of a simple narrow-band imaging (NBI)-based classification system for differentiating hyp

90 wed spectrum endoscopy (narrow-band imaging [NBI], image-enhanced endoscopy [i-scan], and Fujinon int

91 Changes in NBI hospitalization rates following the 2017 management

92 stroenterologists without prior expertise in NBI were able to meet the negative predictive value and

93 ether endoscopists without prior training in NBI can achieve the following thresholds recommended by

94 e centers underwent standardized training in NBI interpretation.

95 dies using the nonselective IGFBP inhibitor, NBI-31772, generated a K(i) value of 47 nM.

96 ation (BI) versus non-bacterial inoculation (NBI) as sub-sub plot.

97 ework suggests that net biotic interactions (NBI), the relative frequency and intensity of facilitati

98 ere compared to proteins (navy bean isolate (NBI) and 7S globulin) prepared using a wet process.

99 re the identification of a nonpeptide ligand NBI-31772, which displaces IGF-I from all six IGF-bindin

100 M-NBI and M-BLI endoscopy demonstrated elongated pits in H

101 difference (M-BLI 95%vs.WLI 80%, p = 0.03; M-NBI 92.5%vs.WLI 80%, p = 0.13; LCI 90%vs.WLI 80%, p = 0.

102 r than WLI, while sensitivities of LCI and M-NBI were also numerically higher than WLI without statis

103 6% and 86% respectively, whereas those for M-NBI were 92.5%, 86.7%, 82.2%, 94.6% and 89% respectively

104 I 90%vs.M-NBI 92.5%, p = 1.00, M-BLI 95%vs.M-NBI 92.5%, p = 1.00).

105 (LCI 90%vs.M-BLI 95%, p = 0.50; LCI 90%vs.M-NBI 92.5%, p = 1.00, M-BLI 95%vs.M-NBI 92.5%, p = 1.00).

106 hniques (LCI, Magnifying-BLI, and Magnifying-NBI) at Thammasat University Hospital, Thailand between

107 locked by intra-BLA treatment with NBI27914 (NBI), a CRF-sub-1 antagonist, but not Astressin 2B, a CR

108 Intraperitoneal administration of NBI-12i stimulated food intake and weight gain in uremic

109 Oral administration of NBI-921352 prevented electrically induced seizures in a

110 esult does not exclude a possible benefit of NBI in reducing variation between endoscopists in detect

111 The higher doses of NBI 27914 blocked the behavioral seizures and prevented

112 The mean frequency of NBI-5788-responsive T cells (stimulation index > 3) in M

113 esponses and the intensity and importance of NBI, all of which will influence drought-induced composi

114 ary-adrenal axis responses to DR infusion of NBI 35965 and CRF, whereas females were minimally respon

115 Subcutaneous injections of NBI-6024 to NOD mice administered either before or after

116 iated with improvements in the management of NBI, contributing to a reduction in nonsevere hospitaliz

117 inclusion when the diagnostic performance of NBI, i-scan, FICE, autofluorescence imaging, or CLE had

118 The protein profile of NBI and 7S globulin was found to be devoid of certain pr

119 The isoform-selective profile of NBI-921352 led to a robust inhibition of action-potentia

120 erences were found in the polyp miss rate of NBI versus HD-WLE: 21.3% versus 26.1% (OR 0.77, 95% CI:

121 ved in the serrated lesion detection rate of NBI versus HD-WLE: 47.4% versus 51.9% (OR 0.84, 95% CI:

122 ary outcomes were monthly incidence rates of NBI hospitalizations per 1000 live births of at least 34

123 between plasma concentration (PK) and %TO of NBI-750142, an experimental inhibitor of the vesicular m

124 This study assessed the utility of NBI in patients with gastroesophageal reflux disease (GE

125 luded 91 studies in our analysis: 56 were of NBI, ten of i-scan, 14 of FICE, 11 of CLE, and 11 of aut

126 d surveillance interval predictions based on NBI.

127 The incidence of late-onset NBI remained stable throughout the study period.

128 ia by people not experienced in endoscopy or NBI analysis (25 medical students, 19 gastroenterology f

129 ple sclerosis (MS) patients who had received NBI-5788, an altered peptide ligand (APL) designed from

130 We found that NBI-12i normalizes the expression of uncoupling protein,

131 The data show that NBI 35965 is a novel water-soluble selective CRF1 antago

132 Here we show that NBI-74330 is anchored in the transmembrane minor pocket

133 The NBI-containing semifluorinated groups and the dendronize

134 dron was attached to the imide groups of the NBI via one, two, and three (m = 1, 2, 3) methylenic uni

135 Amino acid analysis revealed that the NBI and 7S globulin had a lower content of sulfur-contai

136 Thus, NBI-31772 could serve as a valuable lead molecule for th

137 pies, with the order being randomized 1:1 to NBI-HD-WLE or HD-WLE-NBI.

138 in the DR, where blunted female responses to NBI 35965 and CRF suggest unique stress modulation of th

139 yp predictions (74.3% high confidence) using NBI.

140 Valbenazine (NBI-98854) is a novel, highly selective vesicular monoam

141 the interobserver agreement for the various NBI findings was very good, the intraobserver agreement

142 he entire cohort in white light (67%) versus NBI (65%) (P = .61) or in the subset of 257 patients wit

143 colonoscopy withdrawal in white light versus NBI in 434 patients aged 50 years or older with intact c

144 We tested whether NBI-12i would also be effective in attenuating uremia-as

145 ctivity with MBP peptide 83-99 compared with NBI-5788-reactive lines from control MS patients.

146 The surface pit pattern was determined with NBI or FICE in all patients.

147 %TO benchmark, PET was performed in NHP with NBI-98782, the main active metabolite of valbenazine, an

148 ratio of these mice that was normalized with NBI-27914.

149 -time optical biopsy analysis of polyps with NBI, only 25% of gastroenterologists assessed polyps wit

150 by CRF, were abolished by pretreatment with NBI 27914, consistent with their dependence on CRF1 acti

151 rated lesion detection rate was similar with NBI and HD-WLE.

152 d, after biopsy of the lesions targeted with NBI.

153 s are prevented by pre-stress treatment with NBI but not Astressin 2B.

154 two cohorts: NBI-HD-WLE (n = 21) and HD-WLE-NBI (n = 20).

155 being randomized 1:1 to NBI-HD-WLE or HD-WLE-NBI.