ライフサイエンスコーパス: NEP

1 NEP activity was histochemically localized in several, b

2 NEP cells possess gap junctions, express connexins, and

3 NEP cells, however, lacked expression of several lineage

4 NEP decreased with increasing temperature at all low Arc

5 NEP delivery bypassed endocytosis by electrophoretic inj

6 NEP inhibition with sacubitril blunted the ability of GL

7 NEP loss of function 1) elevated whole-brain and plasma

8 NEP was jointly determined by GPP and Re for both inland

9 NEP was not inactivated to a significant extent by HNE,

10 NEP-like activity has also been found in the brain of se

11 grass NEP (median: 20.6 mmol C m(-2) d(-1)), NEP in grazed Caribbean T. testudinum meadows is similar

12 Neutral endopeptidase 24.11 (NEP) is a cell surface peptidase expressed by numerous t

13 e ectodomain of neutral endopeptidase 24.11 (NEP).

14 sites were net sinks for atmospheric CO(2) (NEP ranged from 5 to 67 g C m(-2)), with low Arctic site

15 errestrial net ecosystem production by 8.3% (NEP, 22.25 Pg CO(2) /year) under warming.

16 provide the proof of concept that BMN 111, a NEP-resistant CNP analog, might benefit individuals with

17 a novel pharmacologic agent that combines a NEP inhibitor and an angiotensin receptor blocker.

18 pro-drugs, derived from co-drugs combining a NEP and an APN inhibitor through a disulfide bond with s

19 We developed a NEP fusion protein with in vitro degradation of Abeta an

20 enalapril (10 mg BID, n=2884) or to the ACE-NEP inhibitor omapatrilat (40 mg once daily, n=2886) for

21 concordance between self-reported and actual NEP use; 11.0% reported NEP attendance but did not atten

22 erns, how groundwater accessibility affected NEP was more complex than ET.

23 Again, NEP was localized to regions of the neuropil that also d

24 scribe the implementation of this algorithm, NEP (Neutralization-based Epitope Prediction), as a web-

25 Although NEP stimulates viral RNA synthesis by binding to the vir

26 ACE2 (angiotensin-converting enzyme 2) and NEP (neprilysin) induce the alternative, and potentially

27 ng (1-7) synthesis rates of ACE, chymase and NEP, ACE2, PEP (prolyl-endopeptidase), PCP (prolyl-carbo

28 tation was above normal as effects on ER and NEP offset one another.

29 s demonstrated coherent responses of GEP and NEP to anomalies in annual evapotranspiration (ET), used

30 Since IDE and NEP play a prominent role in the clearance of amyloid be

31 Our studies indicate that Kell and NEP use the same homologous amino acids in the coordinat

32 xtract induced liver, but not brain, LRP and NEP and decreased plasma and brain Abeta, indicating tha

33 wever, significant increase in liver LRP and NEP occurred much earlier, at 7 d, and were accompanied

34 r DNA methylation profiles (MATN3, MDGA1 and NEP), and altered plasma protein levels.

35 lobally; (b) the SSA-induced bias in MTT and NEP correlates negatively with forest age, which provide

36 PB1 A469T and a combination of NS1 N205K and NEP T48N) were identified as determinants of transmissib

37 B1 A469T, PA 1129T, NA N329D, NS1 N205K, and NEP T48N.

38 of the method enables us to quantify NMP and NEP metabolites at current environmental exposures by hu

39 N-Methyl- and N-ethyl-2-pyrollidone (NMP and NEP) are frequently used industrial solvents and were sh

40 th no known occupational exposure to NMP and NEP.

41 one or both of its encoded proteins (NS1 and NEP) are maladapted for replication in mammalian hosts.

42 consensus mutations in PB1, PA, NA, NS1, and NEP genes, additionally was able to confer respiratory d

43 The division of labor between PEP and NEP during plastid development and in mature chloroplast

44 vestigation into the distribution of PEP and NEP promoters within the plastid genome of barley (Horde

45 r photosynthesis proteins) have both PEP and NEP promoters.

46 ed global NPP (Net Primary Productivity) and NEP (Net Ecosystem Productivity) by 0.26 and 0.03 Pg C y

47 , and 57% of the variations in GPP, Re , and NEP, respectively.

48 However, the NEP/Re and NEP/GPP ratios exhibited little variability for inland w

49 mperature dependence of the responsivity and NEP of the GaN HEMT are also analyzed thoroughly.

50 Overall, NPP, Rh and NEP are regulated by highly interrelated effects of incr

51 erreported), and 2.2% reported not attending NEP but did attend (underreported).

52 cycling technology (PCT), using a Barocycler NEP 2320 was compared with the conventional method using

53 Because NEP cleaves substrates other than Abeta, we investigated

54 ed NEP activation may be detrimental because NEP can degrade many physiological peptides, but its con

55 We also found an association between NEP and HRB in the perinuclear region, suggesting that N

56 lin, Notch, and Numb, were expressed by both NEP cells as well as other cell populations.

57 oid precursor protein and having one or both NEP genes silenced.

58 We now provide evidence that membrane-bound NEP is involved in the inactivation of tachykinin-relate

59 Abeta peptide-degrading enzyme in the brain; NEP becomes inactivated and down-regulated during both t

60 ere the most abundant fragments generated by NEP activity in vivo.

61 fferentiation of neuroepithelial stem cells (NEPs) to GRPs to ARPs and then to astrocytes.

62 g neural tube (E10.5, neuroepithelial cells; NEP) were examined for the expression of candidate stem

63 to study the physical properties of complex NEP samples.

64 urements and the challenges posed by complex NEPs both scientists and regulators encourage the combin

65 and increasing woody plant density decoupled NEP and ET from incident precipitation (P), resulting in

66 electrode was successfully applied to detect NEP, MEL and NIC in pharmaceutical and cigarette samples

67 cific DPP-IV inhibitors have been developed, NEP 24.11 targets multiple sites in the GLP-1 sequence,

68 racellular A beta more effectively than does NEP in both the detergent-soluble and -insoluble fractio

69 ssibility that the NPY CTFs generated during NEP-mediated proteolysis might exert neuroprotective eff

70 elivery method, nanochannel electroporation (NEP), to produce predominantly nonendocytic uptakes of q

71 tein levels of nucleus- and plastid-encoded (NEP and PEP) components of the plastid transcriptional m

72 We asked whether a decrease in endogenous NEP levels can prolong the half-life of Abeta in vivo an

73 idase-IV (DPP-IV) and neutral endopeptidase (NEP) 24.11 severely compromises its effective clinical u

74 effect of oleacein on neutral endopeptidase (NEP) activity and other functions of human neutrophils,

75 expression identified neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (I

76 identify a selective neutral endopeptidase (NEP) inhibitor as a potential treatment for FSAD.

77 Neutral endopeptidase (NEP) is expressed on normal prostate epithelium whereas

78 e SP-degrading enzyme neutral endopeptidase (NEP) is increased, compared to control skin.

79 oaches, we identified neutral endopeptidase (NEP) that is up-regulated in human AAA tissue as a major

80 erence for Ang I, was neutral endopeptidase (NEP)-like.

81 to its resistance to neutral-endopeptidase (NEP) digestion.

82 amides (including urea, N-ethylpyrrolidone [NEP], and polyvinylpyrrolidone [PVP]) on protein stabili

83 campal neuronal cells (HT22) over-expressing NEP with the monomeric from of Abeta peptide decreases t

84 n the outer EGL and proliferate extensively, NEPs reside in the deep part of the EGL and are quiescen

85 by HPLC-SEC demonstrated that EAE extracted NEPs with high molecular weight.

86 restingly, the mRNA levels of endogenous fly NEP genes and phosphoramidon-sensitive NEP activity decl

87 year 2004 was climatologically favorable for NEP over North America and the continental total was est

88 ith the lowest detection limit of 1.4 nM for NEP, 2.6 nM for MEL and 1.7 nM for NIC respectively.

89 slightly different distribution pattern for NEP was observed in the brain of L. migratoria.

90 dence for an evolutionary conserved role for NEP in the inactivation of tachykinin-related peptides i

91 ple standard operating procedures (SOPs) for NEP assessment, including the measurements of particle s

92 Neurogenesis of neurons derived from NEP cells identified a second nestin non-expressing neur

93 1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GLP-1, was as cardioprotect

94 Increasing precipitation accelerated GEP, NEP, microbial respiration, soil respiration, and ecosys

95 rrors in the variability of predicted global NEP.

96 bon uptake (GEP) to the shrubland, grassland NEP was substantially less.

97 tudy, we investigated the effect of human (h)NEP gene transfer to the brain in a mouse model of AD be

98 and detrimental effects of chronically high NEP activity in the brain.

99 Healthy kidneys showed higher NEP-mediated Ang (1-7) synthesis than Ang II formation,

100 Using transgenic Drosophila expressing human NEP and Abeta42, we demonstrated that NEP efficiently su

101 al structure of LBQ657 in complex with human NEP at 2 A resolution.

102 ptor to ROCK in PC cells, and they implicate NEP as a major regulator of neuropeptide-stimulated RhoA

103 In NEP/NEP2 double-knockout mice, Abeta levels were margina

104 es in tau phosphorylation, and a decrease in NEP expression in the hippocampus that is coupled with a

105 The drought-induced decrease in NEP, which mostly occurred in the deciduous forests, was

106 GPP contributed equally to the difference in NEP between ENSO year 1998 and non-ENSO year 2000.

107 The spatial difference in NEP between low and high Arctic sites was determined mor

108 es do not lead to significant differences in NEP, which indicates that asymmetry in climate change do

109 P co-immunoprecipitates with ERM proteins in NEP-expressing LNCaP prostate cancer cells and MeWo mela

110 A approximately 50% reduction in NEP levels, similar to that reported in some LOAD brains

111 antly dampens the interannual variability in NEP of the Amazon basin.

112 orth America for the year 2004 that includes NEP as well as the additional emissions.

113 on, improved cognitive function and increase NEP activity in male APP23/Ar(+/-) mice compared with ag

114 he site, which both stimulated and inhibited NEP depending upon phenology.

115 in with a concentration of 100 muM inhibited NEP activity, elastase, MMP-9 and IL-8 release from neut

116 Oleacein by inhibiting NEP activity, adhesion molecules expression and elastase

117 expression in mice treated with intravenous NEP, suggesting that the lack of effects in the brain fo

118 sponsivity Rv of 15.5 and 2.7 kV/W and a low NEP of 0.58 and 10 pW/Hz(0.5) were obtained at room temp

119 re carbon sequestration as a result of lower NEP, it does not promote a metabolic release of current

120 ed with El Nino events, that have the lowest NEP and the highest total (terrestrial plus aquatic) CO(

121 interferes with the stability of the vRNP-M1-NEP nuclear export complex, probably mediated by its hig

122 cockroach peptide LemTRP-1 and the mammalian NEP substrate [DAla(2),Leu(5)]enkephalin at the Gly-Phe

123 rticles (MENPs) through nanoelectroporation (NEP) using alternating current (ac)-magnetic field stimu

124 o P, which resulted in a surprising negative NEP response to P.

125 Neprilysin (NEP) and angiotensin-converting enzyme (ACE) are two key

126 Neprilysin (NEP) appears to be the most potent Abeta peptide-degradi

127 Neprilysin (NEP) is a naturally occuring enzyme that breaks down NPs

128 Neprilysin (NEP) is a zinc-dependent metalloprotease that is one of

129 Neprilysin (NEP) is an endopeptidase, which has an important role in

130 Neprilysin (NEP) is one of the rate-limiting Abeta-degrading enzymes

131 Neprilysin (NEP) is the dominant Abeta peptide-degrading enzyme in t

132 sin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivat

133 er prodrug of LBQ657, the active neprilysin (NEP) inhibitor, and a component of LCZ696 (sacubitril/va

134 Insulysin (IDE) and neprilysin (NEP) were found to be inactivated by oxidation with hydr

135 Abeta-degrading enzymes such as neprilysin (NEP) and insulin-degrading enzyme (IDE).

136 The endopeptidase neprilysin (NEP) is a major amyloid-beta (Abeta) degrading enzyme an

137 execution of two endopeptidases, neprilysin (NEP) and insulin-degrading enzyme.

138 ession of Abeta-degrading enzyme neprilysin (NEP) in primary neuronal cultures.

139 The Abeta-degrading enzyme neprilysin (NEP) is the best known target of these inhibitors.

140 A for the Abeta-degrading enzyme neprilysin (NEP) was found, whereas various Abeta-clearing and -degr

141 idney homogenates, we identified neprilysin (NEP) to be a major source of renal Ang-(1-7) in mice and

142 peptides by proteases, including neprilysin (NEP).

143 rane-bound Zn-metallopeptidases, neprilysin (NEP, EC 3.4.24.11) and aminopeptidase N (APN, EC 3.4.11.

144 nsulin-degrading enzyme (IDE) or neprilysin (NEP) in neurons significantly reduces brain Abeta levels

145 hat the Abeta-degrading protease neprilysin (NEP) is down-regulated in normal aging and LOAD.

146 and the Abeta-degrading protease neprilysin (NEP) occurred 14-21 d after a substantial decrease in br

147 However, neuronal NEP overexpression reduced cAMP-responsive element-bindi

148 However, the protective effects of neuronal NEP expression on intraneuronal Abeta42 accumulation and

149 h GEP and RE, therefore leading to a neutral NEP response.

150 portant biomolecules such as norepinephrine (NEP), melatonin (MEL) and nicotine (NIC) in 0.1 M phosph

151 associate with wild-type NEP protein but not NEP protein containing a truncated cytoplasmic domain or

152 ective down-regulation of liver LRP, but not NEP, abrogated the therapeutic effects of the extract.

153 (split M segment [Ms]) or both M1/M2 and NS1/NEP (Ms and split NS segment [NSs]) open reading frames.

154 e-assisted extraction (EAE) method to obtain NEPs from sweet cherry pomace employing three different

155 al ecosystem respiration (TER) and 25-80% of NEP.

156 However, genetic ablation of NEP results in only modest increases ( approximately 1.5

157 Decreasing the activity of NEP (due to genetic mutations, age or diseases that alte

158 ses that alter the expression or activity of NEP) may lead to accumulation of the neurotoxic Abeta pe

159 Intravenous administration of NEP to wild-type and APP23 transgenic mice resulted in d

160 The cytoplasmic domain of NEP contains a positively charged amino acid cluster, pr

161 r data suggest that the N-terminal domain of NEP interferes with the stability of the vRNP-M1-NEP nuc

162 In contrast, low and high doses of NEP inhibitor did not potentiate the renal actions of DN

163 hat EC and BM provide different estimates of NEP, but comparable ecosystem respiration and gross prim

164 nstrained peptides are the first examples of NEP 24.11-resistant GLP-1 analogues.

165 We conclude that over-expression of NEP by a gene therapy approach in areas vulnerable to Ab

166 cy of lentivirus-mediated over-expression of NEP to protect neuronal cells from Abeta peptide in vitr

167 This suggests that these features of NEP are linked functionally.

168 d the question whether these two features of NEP are linked functionally.

169 This function of NEP represents a unique example of a proteolytic enzyme

170 llowed for the unambiguous identification of NEP promoters.

171 stent with this finding, immunoreactivity of NEP was increased in the hippocampus of AD mice.

172 morbidity further support the importance of NEP inhibition for augmenting natriuretic peptides as a

173 Finally, pharmacologic inhibition of NEP resulted in strongly decreased Ang-(1-7) levels in m

174 d more selective vasopeptidase inhibitors of NEP and ACE for effective treatment in hypertension and

175 In contrast, intracranial injection of NEP resulted in an acute decrease in soluble brain Abeta

176 n normal prostate epithelium whereas loss of NEP expression contributes to PC progression.

177 fore, these data suggest that malfunction of NEP in infected macrophages may contribute to accelerati

178 two newly identified presumed metabolites of NEP, and their corresponding methyl counterparts (5-HNMP

179 extent to which differential misreporting of NEP attendance could bias risk estimates.

180 ons are mediated by the C-terminal moiety of NEP raised the question whether these two features of NE

181 t common sizing technique since the onset of NEP in pharmaceutical technologies.

182 Overexpression of NEP at low levels in transgenic (tg) mice affected prima

183 nd 840 mV, corresponding to the oxidation of NEP, MEL and NIC respectively, indicating that simultane

184 This was accompanied with great reduction of NEP endopeptidase activity, which might be due to the di

185 Down-regulation of NEP activity in aging brains may be an evolutionarily co

186 Since many studies rely on self-reports of NEP attendance, the authors investigated the extent to w

187 This unexpected new role of NEP may have implications for the combination therapy wi

188 Abeta, we investigated the potential role of NEP-mediated processing of neuropeptides in the mechanis

189 might be due to the diminished transport of NEP to the cell surface and intracellular accumulation a

190 ptibility to proteolysis, while treatment of NEP with iron/ascorbate or hydrogen peroxide increased i

191 beta amyloid production and upregulation of NEP activities to enhance bate amyloid degradation.

192 Interannual variability of NEP, gross ecosystem production (GEP), and ecosystem res

193 tical characterization of various classes of NEPs.

194 The estimation of NEPs molecular weight distribution by HPLC-SEC demonstra

195 cate differential developmental potential of NEPs and NNEPs; NNEPs preferentially differentiate as ne

196 icle size distribution and size stability of NEPs, consisting of a quick preliminary step to assess s

197 eason, while SigmaF(aq) significantly offset NEP during the wet season, with a disproportionate contr

198 peratures in spring had a positive effect on NEP in conifer forests but a negative impact in deciduou

199 nding to the individual viral protein NS1 or NEP, without modifying the respective splicing and packa

200 d can be adapted to the measurement of other NEP forms (such as lipid nanoparticle therapeutics) with

201 evations of Abeta, suggesting that yet other NEP-like Abeta-degrading endopeptidases are contributing

202 bridges provided outstanding shielding over NEP 24.11 (half-life of >96 h).

203 ir broad range in the eastern North Pacific (NEP) and identified key environmental factors that influ

204 f the full virion and native empty particle (NEP) of RV-C15a.

205 m of nanotechnology enabled pharmaceuticals (NEPs) submitted for market approval and in clinical appl

206 a nuclear-encoded phage-type RNA polymerase (NEP), which recognize distinct types of promoters.

207 fraction called non-extractable polyphenols (NEPs) remains retained in the extraction residue.

208 THz responsivity and noise equivalent power (NEP) of the device were characterized at 0.14 THz radiat

209 etion in nestin-expressing neural precursor (NEP) cells.

210 ifferentiated to neuroectodermal precursors (NEP), but not to epidermal (EPI) cells and found that tw

211 The presented NEP method can be adopted as a part of future nanotherap

212 ished estimates of net ecosystem production (NEP) and the produced map of young forests, this study e

213 predicted to alter net ecosystem production (NEP) by 64 gCm(-2) yr(-1).

214 k, calculations of net ecosystem production (NEP) defined as terrestrial only may be overestimated by

215 a(-1) yr(-1) lower net ecosystem production (NEP) during ENSO year 1998 compared with non-ENSO year 2

216 despite 79% lower net ecosystem production (NEP) following grazing (24.7 vs. 119.5 mmol C m(-2) d(-1

217 UEe , the ratio of net ecosystem production (NEP) to GPP, was estimated for each site using published

218 , with mean annual net ecosystem production (NEP) varying from -350 to +330 gCm(-2) across sites with

219 oduce estimates of net ecosystem production (NEP, the balance of net primary production and heterotro

220 nd the atmosphere (net ecosystem production, NEP) and its two components, ecosystem respiration and g

221 Net ecosystem production, NEP, is the net exchange of carbon dioxide (CO(2)) betwe

222 ame time overall net ecosystem productivity (NEP) and C sequestration are highest during wet years, p

223 stimation of the net ecosystem productivity (NEP) in these forest ecosystems, a major C sink globally

224 d a reduction of net ecosystem productivity (NEP) of about 6.1-9.3 Tg C y(-1) by 2009.

225 iration (Rh) and net ecosystem productivity (NEP) of six ecosystem types representing different clima

226 nts and seasonal net ecosystem productivity (NEP) proved largely compatible and suggested that carbon

227 nts and seasonal net ecosystem productivity (NEP) proved largely compatible and suggested that carbon

228 ation (Re ), and net ecosystem productivity (NEP) than inland wetlands.

229 olved organic C, net ecosystem productivity (NEP), and gross ecosystem productivity (GEP).

230 , which includes net ecosystem productivity (NEP), ecosystem respiration (ER) and gross ecosystem pho

231 sensitivities of net ecosystem productivity (NEP), gross ecosystem productivity (GEP) and ecosystem r

232 the terrestrial Net Ecosystem Productivity (NEP, calculated as the difference between Net Primary Pr

233 by evaluating net terrestrial productivity (NEP), fire-related C emissions and SigmaF(aq) (comprisin

234 of nanoparticles enabled medicinal products (NEP) in complex biological environments are key attribut

235 cells, these Nestin-expressing progenitors (NEPs) are committed to the granule neuron lineage.

236 ural protein 1 (NS1)/nuclear export protein (NEP) for the modified NS segment were split by using the

237 Protein 1 (NS1), and Nuclear Export Protein (NEP) genes.

238 Intriguingly, the nuclear export protein (NEP) is involved in both processes.

239 with influenza virus nuclear export protein (NEP), during the influenza virus life cycle.

240 une evasion, and the nuclear export protein (NEP), required for the nuclear export of viral ribonucle

241 tein 1 (NS1) and the nuclear export protein (NEP).

242 gmaF(aq) (-28 Mg C km(-2) year(-1) ) reduced NEP by 13% and 7%, respectively.

243 -reported and actual NEP use; 11.0% reported NEP attendance but did not attend (overreported), and 2.

244 These data suggest that restoring NEP levels in the brain at the early stages of AD is an

245 red to other published estimates of seagrass NEP (median: 20.6 mmol C m(-2) d(-1)), NEP in grazed Car

246 ng with the clinically precedented selective NEP inhibitor, Candoxatrilat, and targeting low molecula

247 s fly NEP genes and phosphoramidon-sensitive NEP activity declined during aging in fly brains, as obs

248 featuring room temperature high sensitivity (NEP of 82 pW[Formula: see text]) and fast rise time of 1

249 ngs were supported by MALDI imaging, showing NEP mediated Ang-(1-7) formation in whole kidney cryo-se

250 ctivation of Sonic hedgehog (Shh) signaling, NEPs exhibited more severe genomic instability and gave

251 terminal fragments (CTFs), whereas silencing NEP reduced NPY processing.

252 These data suggest that SP, NEP, and NK-1R serve as important regulators in the mole

253 In contrast, sustained NEP activation may be detrimental because NEP can degrad

254 As terrestrial NEP is the dominant offset to fossil fuel emission over

255 nforest, the leached fraction of terrestrial NEP even reaches 22%.

256 on fluxes within calculations of terrestrial NEP.

257 owever, Kell uses different amino acids than NEP in substrate binding and appears to have more flexib

258 We also demonstrate that NEP inhibits neuropeptide activation of RhoA.

259 human NEP and Abeta42, we demonstrated that NEP efficiently suppressed the formation of intraneurona

260 We report here that NEP co-immunoprecipitates with ERM proteins in NEP-expre

261 In this study, we report that NEP has the dominant endopeptidase activity toward Abeta

262 We reported that NEP inhibits prostate cancer cell proliferation and cell

263 In vitro binding assays showed that NEP binds directly to recombinant N terminus fragments o

264 ved lentiviral vector injections showed that NEP cleaved NPY into C-terminal fragments (CTFs), wherea

265 These data suggest that NEP can affect cell adhesion and migration through direc

266 B in the perinuclear region, suggesting that NEP may contribute to this process.

267 Expression profiling revealed that NEPs are distinct from GNPs and, in particular, express

268 The NEP sensitivity to T(a) anomalies increased with increas

269 The NEP was performed in microglial (MG) brain cells, which

270 The enzyme was acted upon by the NEP inhibitors phosphoramidon (IC(50), 0.64 microM) and

271 ferentiation of glial cells derived from the NEP cells was significantly decreased with no compensati

272 ion for the loss of neurons derived from the NEP pool by the NNEP pool but this was insufficient to a

273 iotensin II while simultaneously halting the NEP-dependent degradation of vasodilator atrial natriure

274 However, the NEP/Re and NEP/GPP ratios exhibited little variability f

275 cross disparate oceanographic regions in the NEP and increased utilization of deeper waters in offsho

276 d miR-96, were uniquely downregulated in the NEP cells.

277 h-resolution approaches to shed light in the NEP sizing space (e.g. dynamic light scattering, electro

278 Of particular interest is the NEP homolog neprilysin 2 (NEP2), which is thiorphan/phos

279 counteracted a large proportion (35%) of the NEP sink.

280 ction between M1 and the vRNP depends on the NEP C terminus and its polymerase activity-enhancing pro

281 dy to determine its breadth and potency, the NEP server can be used to predict antibody-epitope infor

282 flexible intramolecular interaction with the NEP C terminus.

283 tively charged amino acid cluster within the NEP cytoplasmic domain.

284 The synthetic analogues modified within the NEP degradation site ("RPRL" motif) showed improved in v

285 Because the NEPs also display these fingers, they may have utility a

286 Binding of ERM proteins to NEP results in decreased binding of ERM proteins to the

287 nalog, APLN-NMeLeu9-A2, that is resistant to NEP cleavage.

288 Similar to NEP, the Kell protein has 2 globular domains consisting

289 ity need in regulatory science as applied to NEPs such as Doxil and can be adapted to the measurement

290 Moreover, cells expressing wild-type NEP demonstrate decreased adhesion to hyaluronic acid an

291 d that ERM proteins associate with wild-type NEP protein but not NEP protein containing a truncated c

292 Most of the unexplained NEP variability was related to persistent, site-specific

293 riparian sites increased net carbon uptake (NEP) and evapotranspiration (ET), which were sustained o

294 for cell entry in contact exposure, whereas NEP delivery of nanoparticles bypassed endocytosis.

295 erentially differentiate as neurons, whereas NEPs give rise to both neurons and glial cells.

296 approximately 1.5- to 2-fold), compared with NEP(-/-)/NEP2(+/+) controls.

297 ant Kell proteins analyzed and compared with NEP.

298 ASP (a sampatrilat analogue) in complex with NEP at 1.75, 2.65, and 2.6 angstrom, respectively.

299 nt RAS peptide in healthy human kidneys with NEP rather than ACE2 being essential for its generation.

300 mplications for the combination therapy with NEP-inhibitors and angiotensin-receptor-blockade, which

301 Woodland NEP was large, but surprisingly similar to the less matu