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1  transcription of the gene encoding Nf1 (the NF1 gene).
2 pears to be associated with mutations in the NF1 gene.
3 ene (OMgp) is placed within an intron of the NF1 gene.
4 as also seen in cells carrying the exogenous NF1 gene.
5  individual with no detected variants in the NF1 gene.
6 ntaneous autosomal dominant mutations in the NF1 gene.
7 ter by inactivation or overexpression of the NF1 gene.
8 ygous for a loss-of-function mutation in the Nf1 gene.
9 , including the de novo Alu insertion in the NF1 gene.
10 gment gene and the neurofibromatosis type 1 (NF1) gene.
11 nes, including the neurofibromatosis type 1 (NF1) gene.
12 e targets of MMR is the neurofibromatosis 1 (NF1) gene.
13                                          The NF1 gene, a putative tumor suppressor gene, contains a G
14 L show loss of the neurofibromatosis type 1 (NF1) gene, a Ras GTPase activating protein.
15           We therefore hypothesized that the NF1 gene acts as a tumor suppressor gene in pilocytic as
16 g how loss of function of the ASD-associated NF1 gene affects behavior and physiology in Drosophila m
17 hips between small mutations (<20 bp) of the NF1 gene and a specific phenotype have previously been d
18 oss of genetic material involving the normal NF1 gene and approximately 50 Mb of flanking sequence, s
19 arry germline mutations in one allele of the NF1 gene and are predisposed to myeloid malignancies, pa
20             Large deletions encompassing the NF1 gene and its flanking regions belong to the group of
21 sive germline mutations involving the entire NF1 gene and surrounding genes.
22 cis, which is heterozygous for the Trp53 and Nf1 genes and through LOH develops lymphomas, sarcomas,
23 s type 1 (NF1) is caused by mutations in the NF1 gene, and is characterized by the formation of benig
24 observed that multiple variants in the human NF1 gene are associated with a quantitative measure of a
25                          Both alleles of the NF1 gene are inactivated in leukemic cells in some patie
26                              The role of the NF1 gene as a tumor suppressor in pilocytic astrocytomas
27             Loss of function variants in the NF1 gene cause neurofibromatosis type 1, a genetic disor
28        Our results show that mutation in the Nf1 gene causes abnormal keratinocyte proliferation that
29                                          The NF1 gene codes for neurofibromin protein, a GTPase activ
30                                          The NF1 gene contains a 195-bp PATRR within intron 31.
31     Inactivation of the neurofibromatosis-1 (NF1) gene de-regulates RAS and cooperates with mutation
32        Conversely, enhanced ERK activity via Nf1 gene deletion extends the response and rescues both
33           Here, we discuss the importance of Nf1 gene dosage, delineate hematopoietic contributions t
34  mouse spatial learning are controlled in an Nf1 gene dose-dependent manner.
35                                          The NF1 gene encodes a tumor suppressor that most likely act
36                                          The NF1 gene encodes for neurofibromin, a RAS GTPase-activat
37                                          The NF1 gene encodes neurofibromin, a large protein with RAS
38                                          The NF1 gene encodes neurofibromin, a Ras-GAP, highly expres
39                                          The NF1 gene encodes neurofibromin, a tumor suppressor postu
40                     The neurofibromatosis 1 (NF1) gene encodes a cytoplasmic protein with structural
41                The neurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negat
42                The neurofibromatosis type 1 (NF1) gene encodes the GTPase-activating protein (GAP) ne
43 omatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin.
44 ined quantitative and qualitative aspects of NF1 gene expression in six sporadic pilocytic astrocytom
45 al characterization of the effect of reduced Nf1 gene expression on astrocyte function by demonstrati
46 Tax trans-regulator can functionally repress NF1 gene expression through a cis-acting element located
47 sor gene in pilocytic astrocytomas, and that NF1 gene expression would be reduced or absent in these
48 st-transcriptional mechanisms which regulate NF1 gene expression.
49 hanism would suffice to epigenetically alter NF1 gene expression.
50 ral nervous system (PNS) neurons, to reduced Nf1 gene expression.
51  abrogated this association and altered Wsb1/Nf1 gene expression.
52 F1 promoter in vivo and repressed endogenous NF1 gene expression.
53 s in Nf1+/- mice, presumably by inactivating Nf1 gene expression.
54 3 (CRLF3) gene, which is co-deleted with the NF1 gene, functions as a major regulator of neuronal mat
55 tion, human and mouse data indicate that NF1/Nf1 gene haploinsufficiency modulates cellular physiolog
56           Clinical mutation analysis for the NF1 gene has been problematic; a sensitive new assay usi
57                     The neurofibromatosis 1 (NF1) gene has been implicated in astrocyte growth regula
58 ntification of the neurofibromatosis type 1 (NF1) gene, has witnessed great advances in our understan
59                 Six polymorphisms across the NF1 gene have been adapted for genotyping through applic
60        Neurofibromin protein (encoded by the NF1 gene) hydrolyzes GTP directly in complex with KRAS G
61 etion (c.2970-2972 delAAT) in exon 17 of the NF1 gene in all affected subjects.
62 ts in astrocytes and expands the role of the NF1 gene in astrocyte growth regulation.
63 is increasing evidence implicating the human NF1 gene in epithelial carcinogenesis.
64    Specific ablation of a single copy of the Nf1 gene in myeloid cells alone mobilizes a discrete pro
65 studies have revealed critical roles for the NF1 gene in non-neoplastic cells in the tumor microenvir
66 nces in our understanding of the role of the NF1 gene in the molecular pathogenesis of NF1-associated
67 o study the role of the neurofibromatosis-1 (NF1) gene in mammalian brain development, we recently ge
68  transcription of the gene encoding Nf1 (the NF1 gene) in differentiating myeloid cells.
69 h bi-allelic somatic (glial progenitor cell) Nf1 gene inactivation develop brain tumors that do not f
70                            Here we show that Nf1 gene inactivation in adult oligodendrocytes (Plp-Nf1
71   Third, in contrast to the GFAP-Cre strain, Nf1 gene inactivation in NG2+ cells is not sufficient fo
72 lopment, we recently generated mice in which Nf1 gene inactivation occurs in neuroglial progenitor ce
73  an increased frequency, suggesting that the NF1 gene is a critical growth regulator for astrocytes.
74  a pivotal role in motor functioning and the NF1 gene is highly expressed in cerebellar Purkinje cell
75                 First, the expression of the Nf1 gene is largely restricted to neuronal tissues in th
76    Neurofibromin, the protein product of the Nf1 gene, is believed to act as a tumor suppressor, acce
77  type I (NF1), caused by the mutation in the NF1 gene, is characterized by multiple pathological symp
78 omal dominant disorder caused by loss of the NF1 gene, is characterized clinically by neurofibromas a
79 en for identifying genes that cooperate with Nf1 gene loss during progression to acute myeloid leukae
80    We also provide evidence to indicate that Nf1 gene loss induces myeloproliferative disease through
81 ed mice (GEM) in which mono-allelic germline Nf1 gene loss is coupled with bi-allelic somatic (glial
82 cient haematopoietic stem cells we show that Nf1 gene loss, by itself, is sufficient to produce the m
83                                              NF1 gene mutants had shortened life spans and increased
84 mary astrocytes harboring the R681X germline Nf1 gene mutation exhibit increased basal astrocyte prol
85 y, these studies establish that the germline Nf1 gene mutation is a major determinant of optic glioma
86               In addition, specific types of NF1 gene mutation may be associated with an increased ri
87 tions, suggesting that the specific germline NF1 gene mutation may be one factor underlying disease h
88 udy was to define the impact of the germline NF1 gene mutation on brain neurofibromin function releva
89      To determine the impact of the germline NF1 gene mutation on the optic gliomas frequently encoun
90                  We found that each germline Nf1 gene mutation resulted in different levels of neurof
91 mmon tumor predisposition syndrome caused by NF1 gene mutation, in which affected patients develop Sc
92 phenotype, even in individuals with the same NF1 gene mutation, suggests that other factors are invol
93 tonomous and stromal effects of the germline Nf1 gene mutation.
94 g a neomycin insertion (neo) as the germline Nf1 gene mutation.
95 patients, even in families with an identical NF1 gene mutation.
96 ithin individuals who bear the same germline NF1 gene mutation.
97 res, has been attributed to mosaicism for an NF1 gene mutation.
98 oring two representative NF1-patient-derived Nf1 gene mutations (c.2542G>C;p.G848R and c.2041C>T;p.R6
99  first demonstration that different germline NF1 gene mutations differentially dictate neurofibromin
100  system neurons from mice with tumor-causing Nf1 gene mutations exhibit hyperexcitability and increas
101                               Neurofibromin (NF1) gene mutations lead to increased risk of neurofibro
102 cause they harbor biallelic neurofibromin 1 (NF1) gene mutations.
103  protein isoform of the neurofibromatosis 1 (NF1) gene (neurofibromin) containing the alternatively s
104                           The product of the NF1 gene, neurofibromin, is a tumor suppressor which mos
105  heterozygous for a targeted mutation in the Nf1 gene (Nf1+/- astrocytes) exhibit a cell autonomous g
106 ave a constitutional t(17;22) disrupting the NF1 gene on 17q11.
107     Introduction of an exogenous full-length NF1 gene or its GTPase-activating protein (GAP)-related
108                         Although loss of the NF1 gene predisposes to MPNST induction, relatively long
109 , null mutations of the neurofibromatosis-1 (Nf1) gene produce abnormalities of circadian rhythms in
110                         To determine how the NF1 gene product (neurofibromin) regulates astrocyte gro
111                  Based on the ability of the NF1 gene product (neurofibromin) to function as a GTPase
112                                          The NF1 gene product neurofibromin negatively regulates Ras
113 modulates the function of neurofibromin, the NF1 gene product, by inserting the in-frame exon 23a int
114         Here we show that neurofibromin, the NF1 gene product, is a Spred1-interacting protein that i
115  is well established that neurofibromin, the NF1 gene product, is an antioncogene that down-regulates
116                                          The NF1 gene product, neurofibromin, functions as a negative
117 rotubule assembly have demonstrated that the NF1 gene product, neurofibromin, interacts with cytoplas
118                                          The NF1 gene product, neurofibromin, is hypothesized to func
119  effort to determine the contribution of the NF1 gene product, neurofibromin, to astrocyte growth reg
120 nstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse
121 nsin homolog (Pten) and neurofibromatosis 1 (Nf1) genes recently were found to be comutated in high-g
122 romatosis 1 (NF1), and allelic losses of the NF1 gene region on chromosome 17q occur in sporadic pilo
123 NF1-REPa and NF1-REPc, which flank the human NF1 gene region.
124 r a large maternally derived deletion in the NF1 gene region.
125                                              NF1 gene replacement therapy, though promising, is hinde
126                             Mutations in the NF1 gene result in decreased expression of neurofibromin
127 nt therapy, though promising, is hindered by NF1 gene's large size and delivery challenges.
128 are identical to the Alu Ya5a2 insert in the NF1 gene showed that only five have tails with 40 or mor
129 d immunohistochemistry technique, we studied NF1 gene status in S-100 protein-positive and -negative
130 s type 1 (NF1) is caused by mutations in the NF1 gene that encodes neurofibromin, a RAS GTPase-activa
131 isposition syndrome caused by alterations in NF1 gene that lead to tumor growth throughout the nervou
132 vating mutations of the Neurofibromatosis-1 (NF1) gene that predisposes these patients to malignancie
133 omin is a multidomain protein encoded by the NF1 gene, the mutation of which causes Neurofibromatosis
134 ed by heterozygous germline mutations in the NF1 gene, this monogenic condition offers unique opportu
135  The deletions encompassed the entire 350 kb NF1 gene, three additional genes, one pseudogene and 16
136 o correlate a specific small mutation of the NF1 gene to the expression of a particular clinical phen
137 tion, in ICSBP-deficient cells, is decreased NF1 gene transcription.
138  pilocytic astrocytomas overexpress specific NF1 gene transcripts, perhaps as a regulatory response t
139                                          The NF1 gene undergoes alternative splicing of exon 23a (E23
140  by generating a conditional mutation in the NF1 gene using Cre/loxP technology.
141 at the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and th
142 nonsense mutation in exon 31 (R1947X) of the NF1 gene was identified in the lymphocyte DNA of the aff
143 urpose of this study was to determine if the NF1 gene was involved in the pathogenesis of JMML in chi
144                            Surprisingly, the NF1 gene was overexpressed up to fourfold in these tumor
145 zed brains from transgenic mice in which the Nf1 gene was targeted by homologous recombination.
146 e fragments, and truncating mutations of the NF1 gene were found in specimens from 8 of these childre
147 rofibromatosis is caused by mutations in the NF1 gene, which encodes neurofibromin, a large protein t
148 ss-of-function heterozygous mutations in the NF1 gene, which encodes neurofibromin, a RAS GTPase-acti
149 a genetic disease caused by mutations in the NF1 gene, which encodes the protein neurofibromin.
150 atosis 1 (NF1) is caused by mutations in the NF1 gene, which encodes the protein, neurofibromin, an i
151            NF1 is caused by mutations in the NF1 gene, which encodes the RAS GTPase-activating protei
152 ominant condition caused by mutations of the NF1 gene, which is located at chromosome 17q11.2.

 
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