ライフサイエンスコーパス: NHBD

1 NHBD (N = 144) graft survival was significantly shorter

2 NHBD and HBD (n=221) graft survival did not differ at 1

3 NHBD donors remain an important source of hepatic grafts

4 NHBD kidneys are a valuable additional source of organs

5 NHBD renal transplants are underused because of the conc

6 NHBD surgeons must be capable of rapid procurement.

7 NHBDs significantly and safely expanded our donor pool.

8 red by NO: NHBD(1) 0.6+/-1.4*10(9) minute-1, NHBD(2) 1.2+/-1.0*10(9) minute-1, NHBD(2)NO 0.4+/-0.9*10

9 minute-1, NHBD(2) 1.2+/-1.0*10(9) minute-1, NHBD(2)NO 0.4+/-0.9*10(9) minute-1 (P=0.029).

10 Isolated pancreatic islets prepared from 10 NHBDs were compared with those procured from 10 brain-de

11 Samples from human type 2 NHBD and BDD were obtained at the end of cold storage.

12 liary complications occurred in five (33.3%) NHBD recipients; 66.6% of the NHBD biliary complications

13 response to this perception, we reviewed 46 NHBD renal transplants performed in our center since 199

14 1) and airway pressures (NHBD(1) 30.8+/-3.5, NHBD(2) 32.5+/-5.6, NHDB(2)NO 29.4+/-5.3; P=0.0001).

15 72 NHBD and 192 HBD transplants were performed over an eigh

16 All NHBD kidneys were machine-perfused using the Newcastle c

17 he basis of the results of this analysis, an NHBD isolated islet allograft was performed in a type I

18 A single donor transplant from an NHBD resulted in a state of stable insulin independence

19 lications might occur among recipients of an NHBD allograft.

20 Recipients of an NHBD graft had a greater incidence of primary nonfunctio

21 We report the use of an NHBD liver, which was cut into a right-lobe graft and im

22 revealed function-equivalent BDD islets, and NHBD islets transplanted to non-obese diabetic-severe co

23 /- SD] 51+/-14 kPa, NHBD(2) 54+/-16 kPa, and NHBD(2)NO 61+/-6 kPa; P=0.01) and airway pressures (NHBD

24 ceived a hepatic allograft from a controlled NHBD donor.

25 ncreatic, and renal grafts from a controlled NHBD with right replaced and left accessory hepatic arte

26 cess); however, these donors were controlled NHBD, Maastricht category III.

27 Controlled NHBDs contributed 5% of hepatic allografts (8/164) from

28 Controlled NHBDs had catastrophic head injury, prognosis for no mea

29 pancreas is possible from certain controlled NHBDs, even with aberrant anatomy.

30 Because the results of controlled NHBDs (CNHBDs) were acceptable, we have recently tried t

31 Early results suggest that controlled NHBDs are a significant new source of grafts, but carefu

32 ous to the function of ischemically damaged (NHBD) livers.

33 ves the function of non-heart-beating donor (NHBD) canine kidneys.

34 ience of controlled non-heart-beating donor (NHBD) liver transplantation.

35 Non-heart-beating donor (NHBD) livers are an untapped source with the potential t

36 intain viability of non-heart-beating donor (NHBD) livers that have undergone significant warm ischem

37 ing donor (HBD) and non heart-beating donor (NHBD) rats.

38 lung injury in the non-heart-beating donor (NHBD), thereby improving function with longer warm ische

39 or transplantation a non-heartbeating donor (NHBD) liver transplant program was started after obtaini

40 Non-heart beating donors (NHBD) can provide an alternative supply of organs, which

41 ide recruitment of non-heart-beating donors (NHBD) could significantly increase the donor pool.

42 ic allografts from non-heart-beating donors (NHBD) have been cited as a means to expand the supply of

43 on of kidneys from non-heart beating donors (NHBD) is increasingly being used to expand the donor poo

44 Non-heart-beating donors (NHBD) offer a potential source of kidneys that are not c

45 Non-heart-beating donors (NHBD) offer a promising potential to increase the cadave

46 organs taken from non-heart-beating donors (NHBD), but there is still a lack of data to support this

47 at of kidneys from non-heart-beating donors (NHBD).

48 ngs retrieved from non-heart-beating donors (NHBDs) and reperfused with the addition of the beta(2)-a

49 Non-heart-beating donors (NHBDs) are generally not deemed suitable for whole-organ

50 using grafts from non-heart-beating donors (NHBDs) has been shown to be a successful practice.

51 Non-heart-beating donors (NHBDs) have the potential to reduce the increasing numbe

52 liver grafts from non-heart-beating donors (NHBDs) warrants consideration so to expand the donor poo

53 to use marginal and nonheart-beating donors (NHBDs).

54 use of organs from non-heart-beating donors (NHBDs).

55 donors, including non-heart-beating donors (NHBDs).

56 gh differences in patient survival following NHBD versus HBD transplant did not meet statistical sign

57 -year graft survival was 70.2% and 63.3% for NHBD recipients versus 80.4% and 72.1% (P = 0.003 and P

58 er 3 months and the creatinine clearance for NHBD was 44.2+/-2.4 mL/minute and for HBD 49.2+/-3.4 mL/

59 inine clearance was 22.8+/-2.3 mL/minute for NHBD patients and 44.4+/-2.9 mL/minute for HBD patients

60 ial of streptokinase preflush or placebo for NHBD was performed.

61 ospastic effects of ischemia/reperfusion for NHBD than the MPS solution (G1) with or without other ad

62 Our results for NHBD renal transplants confirm that such grafts suffer p

63 may help improve the quality of grafts from NHBD and marginal donors by abrogating the IRI insult.

64 rfused lung model, lungs were retrieved from NHBD rats at varying intervals after death and either ve

65 terest in the use of hepatic allografts from NHBDs.

66 The recovery of islets from NHBDs was comparable to that of control BDDs.

67 Reduction and splitting of livers from NHBDs for transplantation is a realistic option, provide

68 zation of criteria for accepting livers from NHBDs with confounding risk factors is justified.

69 problem observed with kidneys obtained from NHBDs is the endothelial injury seen on protocol core bi

70 ermeability observed in lungs retrieved from NHBDs.

71 tic islets can be isolated successfully from NHBDs.

72 ere retrieved from three groups (n=6): 1 hr (NHBD(1)) and 2 hr with and without NO (NHBD(2)NO, NHBD(2

73 These events are accelerated in NHBD allografts that experience the added insult of host

74 ver, AL was less effective than MPS alone in NHBD kidneys.

75 al and structural changes was intensified in NHBD allografts.

76 rimary nonfunction traditionally observed in NHBD.

77 Because the rapid flush technique is used in NHBD procurement, the inability to palpate arterial puls

78 genation (NHBD(1) [mean +/- SD] 51+/-14 kPa, NHBD(2) 54+/-16 kPa, and NHBD(2)NO 61+/-6 kPa; P=0.01) a

79 al transplantation was minimized by matching NHBD and HBD transplants for the following criteria: don

80 sher 344 rats-->LEW) from 45-min and 105-min NHBDs and from LD controls were placed in additional rec

81 neys from LDs and between 45-min and 105-min NHBDs was also significantly different (100% vs. 87% vs.

82 After routine nephrectomy, NHBD kidneys were machine perfused as part of viability

83 In Newcastle, NHBD kidneys have been used for transplantation for a pe

84 1 hr (NHBD(1)) and 2 hr with and without NO (NHBD(2)NO, NHBD(2)) after hypoxic death.

85 1)) and 2 hr with and without NO (NHBD(2)NO, NHBD(2)) after hypoxic death.

86 phil uptake was significantly lowered by NO: NHBD(1) 0.6+/-1.4*10(9) minute-1, NHBD(2) 1.2+/-1.0*10(9

87 In vitro assessment of NHBD islet function revealed function-equivalent BDD isl

88 This study was a retrospective evaluation of NHBD recipients compared to a group of heart-beating don

89 The function of NHBD and BDD islets was evaluated using in vitro and in

90 After 3 months, the renal function of NHBD cases improved to the level seen in HBD patients.

91 The two groups of NHBD donors and their kidneys were similar in their desc

92 However, almost half of NHBD kidneys are discarded after viability assessment.

93 d patient survival among adult recipients of NHBD hepatic allografts compared with recipients of HBD

94 ent survival is inferior among recipients of NHBD livers.

95 s of early graft failure among recipients of NHBD livers.

96 ethics guidelines would broaden approval of NHBDs.

97 less of whether the kidneys were from HBD or NHBD.

98 left lungs were ventilated with 100% oxygen (NHBD(2)NO with added NO) and perfused for 20 min with ne

99 ransplantation pulmonary venous oxygenation (NHBD(1) [mean +/- SD] 51+/-14 kPa, NHBD(2) 54+/-16 kPa,

100 induced vasoconstricted reperfusion period): NHBD(1) 19+/-9 Wood units, NHBD(2) 28+/-25 Wood units, N

101 rmic preservation on the function of porcine NHBD livers.

102 The use of streptokinase in this porcine NHBD model conferred benefits to donor kidneys when asse

103 lways substantially higher in preconditioned NHBD than in HBD islets.

104 on has the potential to reclaim and preserve NHBD liver tissues.

105 NO 61+/-6 kPa; P=0.01) and airway pressures (NHBD(1) 30.8+/-3.5, NHBD(2) 32.5+/-5.6, NHDB(2)NO 29.4+/

106 This study compared 5-day survival in a rat NHBD liver transplantation model with simple cold storag

107 chemia time), the second kidney was removed (NHBD), flushed, biopsied, and weighed.

108 q/kg of recipient body weight) from a single NHBD successfully reversed the diabetes of a type I diab

109 Sixteen NHBDs afforded 8 livers and 24 kidneys.

110 HBD kidneys functioned better than NHBD kidneys in all groups, as expected.

111 e a lower benefit of HBD islets from HP than NHBD islets.

112 These results indicate that NHBDs may provide an as yet untapped source of pancreati

113 The NHBD kidneys from the streptokinase-treated donors had a

114 The 5 year survival for the NHBD was 73% compared with 65% for HBD kidneys.

115 Major biliary complications in the NHBD recipients resulted in multiple interventional proc

116 d incidence of delayed graft function in the NHBD renal transplants in the perioperative period.

117 l function against reperfusion injury in the NHBD than MPS alone, AL, or AL+TFP.

118 is study using streptokinase preflush in the NHBD was found to improve the condition of the kidneys r

119 n creatinine clearance in HBD but not in the NHBD.

120 n five (33.3%) NHBD recipients; 66.6% of the NHBD biliary complications consisted of intrahepatic str

121 transplants, 105 matched one or more of the NHBD by the criteria outlined above, and thus constitute

122 Presented here are the results of the NHBD renal transplants at the Leicester transplant unit,

123 next consecutive HBD renal transplant to the NHBD transplant.

124 e was significantly enhanced in sham-treated NHBD than in HBD islets.

125 lds were significantly lower in sham-treated NHBD than in HBD.

126 erfusion period): NHBD(1) 19+/-9 Wood units, NHBD(2) 28+/-25 Wood units, NHDB(2)NO 16+/-10 Wood units

127 Reticence to use NHBD kidneys is in part due to concerns over the effect

128 This difference was reduced when NHBD islets were preconditioned.

129 han CS for kidneys exposed to 30 min of WIT (NHBD model).