ライフサイエンスコーパス: NIMA

1 NIMA (never in mitosis arrest)-related kinase 2 (Nek2) i

2 NIMA appears to be particularly important.

3 NIMA expression also induces Ser-10 phosphorylation inap

4 NIMA is also required for TINA, a NIMA-interacting prote

5 NIMA promotes entry into mitosis in late G2 by some mech

6 NIMA promotes NPC disassembly in a spatially regulated m

7 NIMA protein instability during S phase and G2 was also

8 NIMA(d)-exposed splenocytes exhibited bystander suppress

9 NIMA, as well as its most closely related human ortholog

10 NIMA-exposed neonates also developed vigorous primary an

11 NIMA-related kinase 1 (Nek1) has lately garnered attenti

12 NIMA-related protein kinase 2 (Nek2), which regulates ce

13 NIMA-specific Tregs expand during pregnancies sired by m

14 Some (40%) NIMA(d)-exposed mice accepted a DBA/2 allograft while ot

15 and a majority (61%) of adults; nursing by a NIMA+ mother was essential for preserving MMc into adult

16 iated organelle, the spindle pole body, in a NIMA-dependent manner.

17 icate that bimAAPC3 regulates the APC/C in a NIMA-dependent manner.

18 Nek2 is a NIMA-related kinase implicated in regulating centrosome

19 equences from this region identified Nek1, a NIMA (never in mitosis A)-related kinase as a candidate

20 of jck mutation on the expression of Nek8, a NIMA-related (never in mitosis A) kinase, and polycystin

21 terminal noncatalytic tail of Nercc1/Nek9, a NIMA family protein kinase that is activated in mitosis.

22 Genetic analysis now shows that a NIMA-related kinase helps to regulate the size of cilia

23 NIMA is also required for TINA, a NIMA-interacting protein, to locate to SPBs during initi

24 k7, a member of the Never in Mitosis Gene A (NIMA) kinase family, as a regulator of telomere integrit

25 homology with the Never In Mitosis, gene A (NIMA) kinase from the filamentous fungus Aspergillus nid

26 suppression of the Never in Mitosis Gene A (NIMA)-related protein kinase gene NEK4 disrupted timely

27 Never in mitosis A (NIMA)-related kinase 2 (NEK2) is a serine/threonine kina

28 nase Czeta (PKCzeta) and never in mitosis A (NIMA)-related kinase 9 (NEK9).

29 NEK2, which encodes the never in mitosis A (NIMA)-related kinase, by 5aza-dC is context-specific as

30 Rejector and acceptor NIMA(d)-exposed mice had reduced T effector responses an

31 duced cell cycle oscillations require active NIMA, because a nimA5 + bimA1(APC3) double mutant arrest

32 ying tolerance to noninherited maternal Ags (NIMA) are not fully understood.

33 n of tolerance to noninherited maternal Ags (NIMA) is poorly understood.

34 ental exposure to noninherited maternal Ags (NIMA) results in alloantigen-specific natural and adapti

35 the hypothesized direction of effect for all NIMA in women, indicating that increased body iron statu

36 m persists beyond the pregnancy, we analyzed NIMA-expressing kidney and liver transplant recipients.

37 e in the kinase activities of NIMX(cdc2) and NIMA occurs.

38 compatibility, parent-of-origin effects, and NIMA effects at DRB1 are unlikely to play a role in SLE.

39 compatibility, parent-of-origin effects, and NIMA effects at DRB1 in SLE.

40 ctivities of maturation promotion factor and NIMA are coincidentally regulated in A. nidulans and sug

41 esized directions of effect between iron and NIMA, except for rs651007, associated with decreased fer

42 n coordinating the functions of NIMXCDC2 and NIMA in the regulation of mitosis.

43 1, the physical interaction between PINA and NIMA is primarily dependent upon the prolylisomerase dom

44 ositive genetic interaction between PINA and NIMA.

45 es of the APC/C, such as cyclin B, Polo, and NIMA, causing mitotic delay.

46 two nuclear pore complex (NPC) proteins and NIMA is required for mitotic localization of the Cdk1 ki

47 TINA and NIMA preferentially interact in interphase and larger fo

48 Nercc1 binds to another NIMA-like kinase, Nek6, and also binds specifically to t

49 g) cells with noninherited maternal antigen (NIMA) specificity are similarly overturned in daughters

50 that sustain non-inherited maternal antigen (NIMA) tolerance.

51 ission rates (noninherited maternal antigen [NIMA] effects) in other autoimmune diseases have been re

52 ffect of noninherited maternal HLA antigens (NIMA) and double-unit cord blood transplantation (CBT).

53 Exposure to non-inherited maternal antigens (NIMA) during the fetal period induces lifelong split tol

54 lly foreign non-inherited maternal antigens (NIMA) that persists into adulthood.

55 esponses to non-inherited maternal antigens (NIMA), associated with a reduction in inflammatory cytok

56 we investigated the functions of Arabidopsis NIMA-related kinase 6 (NEK6), which regulates microtubul

57 Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper mitotic progre

58 ression of a single Ag, K(b), that served as NIMA.

59 whose products interact with the Aspergillus NIMA cell cycle regulatory protein kinase, reveals that

60 on-invasive measurements of atherosclerosis (NIMA), i.e., presence of plaque, intima media thickness

61 We detected CD9(+) EVs bearing NIMA and PD-L1 in cord blood.

62 Because NIMA triggers nuclear pore complex opening during mitosi

63 We conclude that the beneficial NIMA effect is due to induction of NIMA-specific T(R) ce

64 Specifically, phosphorylation of Sid4 by NIMA(Fin1) reduces Sid4 affinity for its SPB anchor, Ppc

65 e 5'-O-(3-thio)triphosphate, the centrosomal NIMA-related kinase 7 (NEK7) and the adaptor protein ASC

66 The centrosomal NIMA-related kinase 7 (NEK7) disrupts large NLRP3 oligom

67 mpared offspring exposed to maternal H-2(d) (NIMA(d)) with nonexposed controls.

68 ot diminish overall MMc levels, dissociating NIMA-specific tolerance from MMc persistence.

69 The key features distinguishing NIMA(d)-exposed acceptors from all other mice were: 1) h

70 Importantly, at low doses, NIMA-expressing cells induced the development of in vivo

71 hymena thermophila contains 39 loci encoding NIMA-related kinases (NRKs), an extraordinarily large nu

72 ows activation of this prematurely expressed NIMA by phosphorylation.

73 phatase (PP1) from the spindle pole by Fin1 (NIMA) kinase ensures switch-like activation of Cyclin B-

74 Finally, NIMA can phosphorylate histone H3 Ser-10 in vitro, sugge

75 e noncatalytic region, a region critical for NIMA function in Aspergillus nidulans.

76 (high) T cell expressing Foxp3 isolated from NIMA mice.

77 Furthermore, NIMA locates to the NPC during entry into mitosis, and a

78 ne H3 kinase, perhaps helping to explain how NIMA promotes chromatin condensation in A. nidulans and

79 Here, we demonstrate that human NIMA-related kinase 6 (Nek6) is required for mitotic pro

80 In support of this hypothesis, NIMA inactivation is shown to promote interphase septal

81 -negative breast cancer cells, we identified NIMA (never in mitosis gene A)-related kinase 9 (NEK9) a

82 sing a computational approach, we identified NIMA-related kinase 2 (NEK2), a regulator of centrosome

83 ential myosin light chain (ELC) and identify NIMA-related kinase 9 (NEK9) to interact with ELC.

84 substrates of CDK5, casein kinases I and II, NIMA, calmodulin-dependent kinases, Erk1, and phosphoryl

85 To investigate this possibility, we imaged NIMA-green fluorescent protein (GFP) using four-dimensio

86 cells responding to H-2(d)-expressing APC in NIMA(d)-exposed vs control mice.

87 A/2 heart transplant, but were controlled in NIMA(d)-exposed mice by T(R) cells to varying degrees.

88 Loss-of-function variants in NIMA-related kinase 1 (NEK1) constitute a major genetic

89 syndrome caused by mutations that inactivate NIMA-related kinase 10 (NEK10), a protein kinase with pr

90 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) has been frequently overexpres

91 Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) promotes both fibrosis and imm

92 ing of a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) to p53-RS, but not the p53 for

93 ility of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), a key driver of tumorigenesis

94 itors of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), a phosphorylation-specific pe

95 TP1) and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), emerging anticancer targets.

96 ion with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), which blocks MATalpha1 mitoch

97 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)-catalyzed phosphorylation-depe

98 scribe a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)-dependent mechanism that regul

99 E6) and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 protein (Pin1).

100 Its NIMA-like catalytic domain is followed by a noncatalytic

101 ial but functionally enigmatic fungal kinase NIMA.

102 tein (Pin2) that can bind the mitotic kinase NIMA and suppress its ability to induce mitotic catastro

103 by promotes expression of the mitotic kinase NIMA-related kinase 7 (NEK7).

104 The protein kinase NIMA is an indispensable pleiotropic regulator of mitoti

105 The Aspergillus nidulans protein kinase NIMA regulates mitotic commitment, while the human and X

106 otein (Pin2) that associates with the kinase NIMA and suppresses its mitosis inducing activity.

107 nt kinases, polo kinases and Aurora kinases, NIMA-related kinases are emerging as critical regulators

108 Furthermore, when overexpressed, MLK3, like NIMA, localizes to the centrosomal region, induces profo

109 udy of endogenous MLK3 and report that, like NIMA, MLK3 phosphorylation and activity are enhanced dur

110 sis, and TINA is then necessary for locating NIMA back to SPBs during mitotic progression.

111 racterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate substrate Bicd2.

112 of NEK7, a member of the family of mammalian NIMA-related kinases (NEK proteins), as an NLRP3-binding

113 Although several mammalian NIMA-like kinases (Neks) are known, none appears to have

114 rin beta3-binding protein (ITGB3BP), MAP3K8, NIMA-related kinase (NEK2), and SHC-transforming protein

115 At mitosis NIMA-GFP locates to spindle pole bodies (SPBs), which co

116 Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic func

117 At mitosis, NIMA becomes enriched on chromatin and subsequently loca

118 nd Nek6 represent a novel cascade of mitotic NIMA family protein kinases whose combined function is i

119 Of importance, the mitotic NIMA kinase locates to forming septa and surprisingly th

120 The family of human Nek (NIMA Related Kinase) kinases currently contains 11 membe

121 Nek2 (NIMA-related kinase 2) is a serine/threonine-protein kin

122 Hec1 (highly expressed in cancer 1) or Nek2 (NIMA-related kinase 2) is often overexpressed in cancers

123 Recent advances in understanding Nek2 (NIMA related kinase 2) biology suggest that the kinase p

124 NEK6 (NIMA-related kinase 6) is a homologue of the Aspergillus

125 inactive NLRP3 cage, the active NLRP3-NEK7 (NIMA-related kinase 7)-ASC inflammasome disk, and the PY

126 Nercc1 is a new NIMA-like kinase that regulates chromosome alignment and

127 The Aspergillus nidulans NIMA kinase is essential for mitotic entry.

128 alleles arrest in G2, before accumulation of NIMA in the nucleus.

129 f PINA and the C-terminal 303 amino acids of NIMA.

130 est but had little effect on the activity of NIMA.

131 ctive CaMK also results in the appearance of NIMA kinase activity within 1 h of the germinating signa

132 ace TGF-beta expression on CD4(+) T cells of NIMA(d)-exposed vs control splenocytes.

133 maternal cells that promote conservation of NIMA and enforce cross-generational reproductive benefit

134 hat partial NPC disassembly under control of NIMA and Cdk1 in A. nidulans may represent a new mechani

135 kinases, and accumulation and degradation of NIMA, which all coordinately cycle multiple times withou

136 s that received a transplant of low doses of NIMA-like alloantigens develop vigorous memory cytotoxic

137 l, we conclude that exposure to low doses of NIMA-like alloantigens induces robust in vivo cytotoxic

138 An effect of NIMA was also found to extend the survival of skin graft

139 n of p34cdc2 allows precocious expression of NIMA during S-phase arrest, and lack of BIME then allows

140 Mc depletion overturned hallmark features of NIMA-specific tolerance including FOXP3(+) regulatory T

141 condensation, activation and inactivation of NIMA and p34(cdc2) kinases, and accumulation and degrada

142 Although inactivation of NIMA using either the nimA1 or nimA5 temperature-sensiti

143 Most strikingly, ectopic induction of NIMA promotes mitotic-like changes in NPC structure and

144 eneficial NIMA effect is due to induction of NIMA-specific T(R) cells during ontogeny.

145 We investigated the influence of NIMA exposure on the offspring thymic T cell selection d

146 suggest that early exposure to low levels of NIMA may lead to long-term immunologic priming of all ar

147 flects differences in the relative levels of NIMA-specific T regulatory (T(R)) versus T effector (T(E

148 The chromatin-like localization of NIMA early in mitosis is tightly correlated with histone

149 We hypothesized that maintenance of NIMA-specific T(R) cells in the adult requires continuou

150 ) tests to detect MMc in different organs of NIMA(d)-exposed H2(b) mice.

151 The average percentage of NIMA-XD among total DCs was 2.6% for myeloid and 4.5% fo

152 with homology to the noncatalytic region of NIMA and identified mixed lineage kinase 3 (MLK3).

153 ertebrate systems as a negative regulator of NIMA, a Ser/Thr protein kinase that regulates the G(2)/M

154 mitosis, and a dominant-negative version of NIMA that causes G2 delay dwells at the NPC.

155 n in a cyclic manner; these cycles depend on NIMA.

156 ells without markedly increasing NIMXCDC2 or NIMA kinase activity.

157 s nidulans by inactivating either p34cdc2 or NIMA.

158 les expressing alloantigens with overlapping NIMA specificity, thereby averting fetal wastage trigger

159 e mutations in the Schizosaccharomyces pombe NIMA homologue, Fin1, blocked spindle formation at 37 de

160 The mitosis-promoting NIMA kinase is thus a target for S-phase checkpoint cont

161 The Aspergillus nidulans protein NIMA (never in mitosis, gene A) is a protein kinase requ

162 omologue of the Aspergillus nidulans protein NIMA (never in mitosis, gene A).

163 h PINA is essential and positively regulates NIMA function, A. nidulans is most sensitive to a reduct

164 sequence to the essential mitotic regulator NIMA of Aspergillus nidulans.

165 ructurally related to the mitotic regulator, NIMA, of Aspergillus nidulans.

166 Mitotic modification of the NPC requires NIMA and Cdk1 kinase activation.

167 ain homology to NIMA, none of these resemble NIMA within its extensive noncatalytic region, a region

168 Two of six NIMA-related SNPs showed association with the ratio hepc

169 Here, we show that another APC/C substrate, NIMA-related kinase 2A (Nek2A), is also destroyed in pro

170 rnal cells and/or soluble MHC Ags suppresses NIMA-allospecific T cells of the offspring, predisposing

171 see how this may apply to humans, we tested NIMA acquisition by fetal DCS in human cord blood.

172 ecipitation assays, we demonstrate here that NIMA (never in mitosis gene A)-related kinase 2 (NEK2) i

173 These results indicate that NIMA promotes the nuclear localization of the NIMXCDC2/

174 letion of individual MMc subsets showed that NIMA-specific tolerance is sustained exclusively by micr

175 histone H3 Ser-10 in vitro, suggesting that NIMA is a mitotic histone H3 kinase, perhaps helping to

176 The NIMA family protein kinases Nek9/Nercc1, Nek6, and Nek7

177 The NIMA kinase is essential for progression through mitosis

178 The NIMA kinase is required for mitotic nuclear pore complex

179 To analyze the NIMA effect C57BL/6 (H-2(b/b)) males were mated with B6D

180 tion between the two elements by MPF and the NIMA kinase Fin1 blocked PP1(Dis2) recruitment, thereby

181 leoporins SONA(GLE2) and SONB(NUP98) and the NIMA kinase interact and regulate nuclear accumulation o

182 urified from rat liver and identified as the NIMA-related kinases NEK6 and NEK7.

183 To help expand the NIMA-TINA pathway, we affinity purified TINA and found i

184 In this study, we identified the NIMA kinase Nek4 in a genetic screen for mediators of th

185 However, if the NIMA mitosis-promoting kinase is inactivated then non-ty

186 Recent work has implicated the NIMA (never in mitosis, gene A)-related kinase-6 (NEK6)

187 Interestingly, the NIMA kinase of Aspergillus nidulans interacts with two n

188 -ATRIP, we found that a single member of the NIMA (never in mitosis A)-related kinase family, Nek1, i

189 rylation is dependent upon activation of the NIMA kinase in Aspergillus nidulans.

190 ted prematurely by ectopic expression of the NIMA kinase.

191 d a mutation affecting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient w

192 Nek5 is a poorly characterized member of the NIMA-related kinase family, other members of which play

193 st in part, with decreased expression of the NIMA-related kinase NEK2.

194 The localization of the NIMA-related kinase, Fin1, reveals further complexity in

195 a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 that is

196 unit CBT and the correlation of MMc with the NIMA effect.

197 ns encodes a protein that interacts with the NIMA mitotic protein kinase in a cell cycle-specific man

198 we identify a new pathway that acts through NIMA-related kinase 6 (Nek6) and Hsp72 to promote centro

199 ortance for mitotic regulation attributed to NIMA.

200 In contrast to NIMA and the closely related mammalian Nek2 kinase, whic

201 A and upregulation of PD-L1, contributing to NIMA tolerance.

202 Strikingly, adult mice exposed to NIMA accepted permanently K(b+) heart allografts despite

203 ed that anti-K(b) thymocytes were exposed to NIMA and became activated during fetal life but were not

204 owed that both oral and in utero exposure to NIMA are required for this tolerogenic effect.

205 Therefore, exposure to NIMA selectively enhances reproductive success in second

206 In the absence of neonatal exposure to NIMA via breastfeeding, MMc was lost, which was accompan

207 identified with catalytic domain homology to NIMA, none of these resemble NIMA within its extensive n

208 n amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of s

209 t, which was accompanied by sensitization to NIMA in some offspring, indicating a role of oral exposu

210 In addition, we observed that tolerance to NIMA K(b) was abrogated via depletion of CD4(+) but not

211 of Tregs and 'tolerizes' the neonate towards NIMA.

212 Nek2B is a vertebrate NIMA-related protein kinase required for centrosome asse

213 However, during mitosis, when NIMA transiently locates to nuclei to promote mitosis, i

214 Whereas NIMA-specific tolerance is functionally erased by pregna

215 ize them to the graft, may determine whether NIMA-specific tolerance is achieved.

216 A model is proposed in which NIMA helps keep septal pores open during interphase and

217 es during the cell cycle and associates with NIMA-related kinase 2 (NEK2), which is able to phosphory

218 (XD) of offspring dendritic cells (DC) with NIMA and upregulation of PD-L1, contributing to NIMA tol

219 lates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity.

220 is-trans isomerase (PPIase) interacting with NIMA-1 (Pin1) catalyzes the cis-trans isomerization of p

221 ond nucleoporin genetically interacting with NIMA.

222 3 to further facilitate its interaction with NIMA-related kinase 7 (NEK7), ultimately leading to full

223 trans isomerase (PPIase) that interacts with NIMA.

224 he relevance of the interaction of PINA with NIMA in this fungus.

225 SNPs and quartiles of a multi-SNP score with NIMA.

226 suppressive regulatory T cells (Tregs) with NIMA specificity.