ライフサイエンスコーパス: NLS

1 using the methylation-state-responsive DCL4(NLS).

2 n in the nuclear localization signal (TDP-43-NLS).

3 domain and two nuclear localization signals (NLS).

4 ions in the FUS nuclear localization signal (NLS).

5 t resembles a nuclear localization sequence (NLS).

6 dNTPase) with a nuclear localization signal (NLS).

7 he FMDV 3D(pol) nuclear localization signal (NLS).

8 ts N-terminal nuclear localization sequence (NLS).

9 no significant changes in ONs compared with NLs.

10 methylation percentage in ONs compared with NLs.

11 in three consanguineous families affected by NLS.

12 ic section defining the motif as a bipartite NLS.

13 og recapitulates many of the key features of NLS.

14 yrosine-NLS, which is missing from the dsRBD-NLS.

15 , nevertheless, a bona fide monopartite-type NLS.

16 er and the degree of the double helix of the NLS.

17 ility of the nearby C2 domain containing the NLS.

18 or of the intervening sequence within the PY-NLS.

19 the synapse organizing function of multiple NLs.

20 rated to bind small domains connected to the NLS.

21 rtite NLSs, such as c-myc and SV40 T-antigen NLSs.

22 17-36 nm, with tuneable numbers of up to 240 NLSs.

23 des containing nuclear localization signals (NLSs) 1 and 2 were non-acetylated, and all cysteine resi

24 importin-beta family proteins, binds to a PY-NLS(2) sequence motif close to the amino terminus of mat

25 The resultant M1 triple mutant M(NLS-88R) regained replication efficiency in vitro while

26 Unlike the other M1 triple mutants, M(NLS-88R) replicated more efficiently in vitro and in viv

27 ctron microscope, only the M1 layer of the M(NLS-88R) virion exhibited discontinuous fingerprint-like

28 th or without pretreatment with IPSE or IPSE-NLS (a mutant of IPSE lacking nuclear localization seque

29 es contain two nuclear localization signals (NLSs): a well-studied monopartite NLS1 and a less-charac

30 RBM45 mutants that lack a functional NLS accumulate in the cytoplasm and form TDP-43 positive

31 TDP-43-NLS accumulation in retinal cells was counteracted by HS

32 Three of the elements showed autonomous NLS activity and the fourth served as a nuclear localiza

33 o wedge the RCC1 beta-propeller flanking the NLS against its lateral surface, preventing steric clash

34 The 3D(pol) NLS alanine substitutions of T19 and L21 results in aber

35 We propose that swapping NLSs among terminase subunits is a regulatory mechanism

36 possesses two nuclear localization signals (NLS): an N-terminal monopartite NLS and a unique biparti

37 ion signals (NLS): an N-terminal monopartite NLS and a unique bipartite NLS closer to the C terminus.

38 eta-propeller, or inserting a linker between NLS and beta-propeller, disrupts specificity for importi

39 MDGA proteins bind NLs and control their function and interaction with NRXs

40 del showing how Trn1 can recognize the dsRBD-NLS and how dsRNA binding can interfere with Trn1 bindin

41 we isolated proteins that interact with the NLS and identified karyopherin alpha 3 (KPNA3 or Kap-alp

42 Although a classical NLS and importin alpha/beta mediated nuclear import path

43 ent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localization in HEK29

44 -2 missense allele that disrupts a predicted NLS and lowers the abundance of CRWN4 in the nucleus.

45 es insights into the nature of the potential NLS and the mechanistic relationship between I2 (PP2A)-i

46 A-GTP binding domain, which autoinhibits the NLS and the neighboring microtubule-binding domain, and

47 d DHA in phospholipids and TLs and of EPA in NLs and TLs (P </= 0.05).

48 eveals the organization of the intermingling NLSs and NoLSs in AAP2 and provides insights into their

49 hat AAP2(144-184) has redundant multipartite NLSs and that any combinations of 4 AAP2BRs, but not 3 o

50 ese proteins, a nuclear localization signal (NLS) and an intrinsically disordered linker encode the s

51 with weakened nuclear localization signals (NLS) and deficient nuclear interactions with the SYNV nu

52 and nucleus due to its nuclear localization (NLS) and export sequences (NES).

53 that acts as a nuclear localization signal (NLS) and in template binding is also involved in nucleot

54 an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nucleus.

55 s a conserved nuclear localisation sequence (NLS) and nuclear export sequence (NES), suggesting a rol

56 fy and characterize AAV2 AAP (AAP2) nuclear (NLS) and nucleolar (NoLS) localization signals near the

57 d a bipartite nuclear localization sequence (NLS) and thereby controlled the partitioning of Cdh1 bet

58 eceptors via nuclear localisation sequences (NLSs) and the effect of size on import efficiency.

59 ere separated into free FAs, neutral lipids (NLs), and phospholipids by using solid-phase extraction,

60 the CTD of topo IIbeta, while preserving the NLS, and mutation of Y640 in topo IIalpha and Y656 in to

61 terial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodell

62 t substitutions at residues 18 and 20 of the NLS are defective in proper incorporation of nucleotides

63 NLs are motivated community members who influence their

64 ns between neurexins (Nrxs) and neuroligins (NLs) are essential for synapse structure, stability, and

65 Our findings expand our understanding of NLS as a disorder of the L-serine biosynthesis pathway a

66 trial to evaluate training natural leaders (NLs) as an addition to a community-led total sanitation

67 ignals and the nuclear localization signals (NLSs), as well as the nuclear export signals (NESs), in

68 Surprisingly, the NLS-associated locus identified in this study was solved

69 ontrast, small terminase exposes a classical NLS at the far C terminus of its helical structure that

70 We found a monopartite NLS at the N terminus of large terminase, flanking the A

71 ins a conserved nuclear localization signal (NLS) at its C-terminus that binds to importin-beta and i

72 he nucleus with nuclear localization signal (NLS)-bearing paralogues in the NMCP1-clade was discounte

73 NLS2 revealed NLS2 primarily binds the major-NLS binding site of importin alpha, unlike NLS1 that ass

74 ue nonclassical nuclear localization signal (NLS) binding site on KPNA5 that is necessary for efficie

75 although the two isoforms share an identical NLS-binding groove.

76 d in rosette leaves have an almost identical NLS-binding site.

77 ha, sequence variation at the importin-alpha NLS-binding sites and tissue-specific expression levels

78 e size, and polydispersity index of Betalain NLs (BNLs) didn't change significantly during storage (4

79 nctions of M1 in the presence of a disrupted NLS but also resulted in a strong association of M1 with

80 HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclea

81 (775)KKARL functioned as the primary NLS, but (737)KRK and (754)KK also contributed to the nu

82 g does not affect the transport of classical NLS cargo.

83 dependent manner that is directly coupled to NLS-cargo release and NPC barrier function.

84 (NPC) barrier selectivity, Kap traffic, and NLS-cargo release are systematically linked and simultan

85 localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

86 expression between cells expressing CD24 and NLS-CD24 revealed a unique nucCD24 transcriptional signa

87 Nuclear-specific expression of CD24 (NLS-CD24) increased anchorage-independent growth in vitr

88 minal monopartite NLS and a unique bipartite NLS closer to the C terminus.

89 e, we developed nuclear localization signal (NLS)-conjugated polymersome nanocarriers (NLS-NCs) and s

90 ion elements defined a new form of bipartite NLS consisting of a triplet of basic residues followed b

91 otably, the PB2 nuclear localization signal (NLS)-containing domain translocates approximately 90 A t

92 its binding to nuclear localization signal (NLS)-containing proteins that regulate nuclear and spind

93 ined that srp1 mutants that failed to import NLS-containing proteins (srp1-31 and srp1-55) successful

94 (srp1-49 and srp1-E402Q) were able to import NLS-containing proteins.

95 intracellular proteolysis and the import of NLS-containing proteins.

96 easome localization defect and the import of NLS-containing proteins.

97 The C-terminal NLS contains a SUMO-interacting motif that contributes t

98 From 39 genes differentially expressed in NLS-CSU when compared with HCs, 31 (79.48%) were confirm

99 R), relevant genes expressed in nonlesional (NLS-CSU) and lesional skin (LS-CSU) and peripheral blood

100 From the analysis comparing LS-CSU with NLS-CSU, a selection of 142 genes was studied with qPCR,

101 R1 and its natural ligand, collagen, lack an NLS, DDR1 is present in the nucleus of injured human and

102 Mutating the NLS decreases anillin's cortical affinity, causing it to

103 mes flexible in the open state, with 627 and NLS dislocating into a highly dynamic ensemble.

104 preserving the nuclear localization signal (NLS), enhances the decatenation checkpoint and sensitivi

105 biotic stress correlates with enhanced DCL4(NLS) expression, while hypermethylation of a DCL4 transg

106 a DCL4 transgene causes a reduction in DCL4(NLS) expression.

107 of TAP, whereas an HDAg-L mutant lacking the NLS failed to interact with full-length TAP.

108 The molecular basis of the affinity of 627-NLS for importins remained unclear from these structures

109 e SR protein substrate and appropriating its NLS for transport.

110 ora sojae uses nuclear localization signals (NLSs) for translocation of proteins into the nucleus tha

111 haracterize the genetic pathways controlling NLS formation in cereals.

112 omic response occurring in rice roots during NLS formation, 7 days post-treatment (dpt) with auxin, 2

113 enes were not expressed in rice roots during NLS formation.

114 olecular mechanisms governing nodulation and NLS formation.

115 curring in rice roots at different stages of NLS formation: early (1-dpt) and late (14-dpt).

116 After 5 months, Plan trained eight NLs from a randomly selected half of the villages, then

117 tion of a membrane protein in yeast, but the NLS from RnPom121 is.

118 differ from conventional well-characterized NLSs from mammals and yeast.

119 ne substitution being sufficient to abrogate NLS function and virus growth.

120 om all herpesvirus subfamilies, demonstrated NLS function, dissected key residues, and showed functio

121 h precise knock-in mutations to incapacitate NLS function.

122 DCL4(NLS) functions in a noncanonical siRNA pathway, producin

123 ue by mapping both intranuclear diffusion of NLS-GFP and recovery of 53BP1-mCherry, a marker for DNA

124 2D maps of NLS-GFP recovery times showed no pixel-by-pixel correlat

125 0 nm) heterogeneity in the recovery times of NLS-GFP, which is validated against simulated data sets.

126 fected cells, we employed the interaction of NLS-GFP-MS2 (phage MS2 coat protein) with the modified B

127 f Vpx-containing virions with the cells, the NLS.GFP.SAM595 fusion protein was degraded over several

128 l lines that express a fusion protein termed NLS.GFP.SAM595 in which the Vpx binding domain of SAMHD1

129 Thus a Cdk-inhibited NLS goes along with Cdk-inhibited APC/C binding sites in

130 OP reductions, with the largest reduction in NLS group (-6.78 mmHg).

131 These findings suggest that NLS has potential for development into a safe and potent

132 ) deposited on the surface of nanoliposomes (NLs) has been synthesized and characterized.

133 diffraction observations confirmed that the NLs have been successfully coated by biopolymeric blends

134 urthermore, 5-FU increased RAGE and NFkappaB NLS immunostaining in enteric neurons, associated with a

135 Retention of the C-terminal NLS in anillin homologues suggests that this is a conser

136 Mutating the PY-NLS in Gli or knockdown of Kapbeta2 diminished Gli cilia

137 stand the role of individual residues of the NLS in nuclear localization and nucleotide incorporation

138 In addition, we predicted a classical NLS in the third terminase subunit that is partially con

139 consistent with a requirement for an intact NLS in this interaction.

140 t receptor, KPNA2, which binds the bipartite NLS in Tpr with nanomolar affinity.

141 We propose NLS1 and NLS2 form a bipartite NLS in trans, which ensures high avidity for importin al

142 inally, PC3 xenograft nude mice treated with NLS in vivo showed a significant decrease in tumor size

143 ng enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests tha

144 s revealed that both location and potency of NLSs in terminase subunits evolved more rapidly than the

145 ine-tyrosine nuclear localization signal (PY-NLS) in DJ-1, and we found that nuclear monomeric DJ-1 i

146 uce the formation of nodule-like structures (NLS) in plant roots even in the absence of bacteria.

147 during formation of nodule-like structures (NLS) in rice and compared rice RNA-seq dataset with a no

148 of a potential nuclear localization signal (NLS) in the C-terminal region of I2 (PP2A) containing a

149 wo independent nuclear localization signals (NLSs) in Gag.

150 NLS induced a significant decrease in cell viability and

151 NLS induced cell apoptosis and cell cycle G1/S phase arr

152 the entire N-terminal domain, including the NLS, interacted with TCPs but did not destabilize them.

153 y a tripartite salt bridge involving the 627-NLS interface and the linker, that becomes flexible in t

154 ma subjects who underwent a single laser, or NLS intervention, and/or took the same medication for at

155 that contain a nuclear localization signal (NLS) into the nucleus.

156 We conclude that the NRF-2beta NLS is an unusual but is, nevertheless, a bona fide mono

157 trate experimentally that the atypical ADAR1-NLS is bimodular and is formed by the combination of the

158 es affected by NLS, we provide evidence that NLS is genetically heterogeneous and can be caused by mu

159 The primary NLS is in the nucleocapsid (NC) domain of Gag and binds

160 This dsRBD-NLS is recognized by the nuclear import receptor transpo

161 Neu-Laxova syndrome (NLS) is a rare autosomal-recessive disorder characterize

162 Neu-Laxova syndrome (NLS) is a rare autosomal-recessive disorder characterize

163 te that nuclear localization of Mre11 (Mre11-NLS) is able to bypass several functions of Xrs2, includ

164 n sequence, the nuclear localization signal (NLS) is reported to reside between amino acids 255-271,

165 encoding a nuclear localization signal, DCL4(NLS), is present in Arabidopsis, but DNA methylation nor

166 t of 21-nucleotide-long "disiRNAs," for DCL4(NLS) isoform-dependent siRNAs, through the nuclear RdDM

167 the PY-type nuclear localization signal (PY-NLS)/karyopherinbeta2 (Kapbeta2) nuclear import system r

168 A nuclear localization signal (NLS) knock-out mutant N did not activate NF-kappaB, and

169 NBS1, the individual deletions of PS and one NLS (KRMK) robustly reduced the interaction.

170 ion studies in nulliparous mice that carry a NLS-lacZ transgene downstream of the Mmp14 promoter reve

171 ments (medication, laser, non-laser surgery (NLS), laser + medication, and NLS + medication) on 1-yea

172 y a bipartite nuclear-localization sequence (NLS) located at the C-terminus.

173 ctionality of a nuclear localization signal (NLS) located at the N-terminal region of the foot-and-mo

174 rom a bipartite nuclear localization signal (NLS) located in the tail domain [14].

175 The functional nuclear location signal (NLS) mapped to 3 clusters of basic residues.

176 hat, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.

177 n of TNPO1 and TNPO3 with these nonclassical NLSs may regulate the formation of membraneless organell

178 t a monopartite nuclear localization signal (NLS) may reside in the N-terminal lyase domain.

179 ted form of parvalbumin fused to mCherry (PV.NLS-mC) led to a reduction in VEGFD expression and, as a

180 1q-c were increased in neurons expressing PV.NLS-mC, causing a reduction in the density and size of d

181 ther the interaction of AbetaOs with Nrxs or NLs mediates synapse damage and cognitive impairment in

182 laser surgery (NLS), laser + medication, and NLS + medication) on 1-year intraocular pressure (IOP) c

183 In this model, the mutant NLS (mNLS)-I2 (PP2A) (I2 (PP2A)AA-AAA) was retained in t

184 as an RNA-sensing scaffold, allowing the two NLS modules to be properly positioned for interacting wi

185 ignal (NLS) motif, whilst Cry3 lacks both an NLS motif and a protein-protein interaction domain.

186 MDV 3D(pol), suggesting that the role of the NLS motif in similar viral polymerases needs to be revis

187 lication defect of an HSV mutant lacking its NLS motif.

188 ucine-lysine nuclear localization signal (IK-NLS) motif at residues 35-40.

189 e presence of a nuclear localization signal (NLS) motif within the GmHSP40.1 coding sequence, GFP-GmH

190 does possess a nuclear localization signal (NLS) motif, whilst Cry3 lacks both an NLS motif and a pr

191 Dual NLS motifs are common among transcription factors.

192 tional tools: how many of the ~500 available NLS motifs are needed to establish infection?

193 ut they nevertheless functioned as efficient NLS motifs both in heterologous transfer assays and in H

194 esent, resulting in 3 different, overlapping NLS motifs; and the NoLS is shared redundantly among the

195 te C-terminal nuclear localization sequence (NLS) motifs conserved in H03-IPSE, SKRRRKY, and H06-IPSE

196 NLS mutant mice had no gross changes in immunophenotype

197 A colony of NLS mutant mice was successfully generated with precise

198 rmed by fluorescent imaging of wild-type and NLS-mutated pol beta(R4S,K5S) in mouse embryonic fibrobl

199 a cells expressing the ALS-causing FUS R495X NLS mutation, and mislocalization of Sm proteins is RRM-

200 Moreover, SYNV with M NLS mutations exhibited compromised SIE against wild-typ

201 ion electron microscopy further resolves the NLS-NCs on transit in NPCs and inside the nucleus.

202 e required to authenticate, bind, and escort NLS-NCs through NPCs while Ran guanosine triphosphate (R

203 l (NLS)-conjugated polymersome nanocarriers (NLS-NCs) and studied the NCT mechanism underlying their

204 Functional NLSs, NES, and GSK3-beta-dependent phosphorylation regul

205 t not 3 or less, can constitute a functional NLS-NoLS; AAP2BR1 and AAP2BR2 play the most influential

206 bidopsis thaliana RPL23aA has eight putative NLSs/NoLSs (pNLSs/NoLSs).

207 mics abrogates nuclear transport, preventing NLS (nuclear localisation signal)-cargo release from Ran

208 s NLS of Pom121 adapts a similar fold as the NLS of Heh2 when transport factor bound and rescues the

209 This NLS of Pom121 adapts a similar fold as the NLS of Heh2 w

210 Here, we have characterized in depth the NLSs of a P. sojae basic leucine zipper transcription fa

211 We show that the (putative) NLSs of metazoan HsSun2, MmLem2, HsLBR, and HsLap2beta a

212 The conserved features of the NLSs of ScHeh1, ScHeh2, and RnPom121 and the effective s

213 importins with nuclear localization signals (NLSs) of cargo proteins not only mediates nuclear import

214 rs (NIRs) bind nuclear-localization signals (NLSs) of protein cargo in the cytoplasm and transport th

215 R/Cas9 to make inactivating mutations to the NLS on the Il1a gene.

216 wo different nuclear localization sequences (NLS) on the C terminus provide increased editing efficie

217 d in a putative nuclear localization signal (NLS) on the Drosophila melanogaster PER protein.

218 ant lacking the nuclear localization signal (NLS) on the ICP0 gene (0DeltaNLS) is sensitive to inhibi

219 which was rescued by the introduction of an NLS onto APLF.

220 ry for its function, because deletion of the NLS or addition of a nuclear export signal abolished its

221 cancer cells expressing K17 mutations in its NLS or NES signals exhibited an increase in levels of nu

222 tifying the genetic switches controlling the NLS organogenesis program in crops, especially cereals,

223 e fed a high-fat diet), i.p., 0.13 mumol/day NLS peptide administration for 5 weeks attenuated NF-kap

224 is development and identifies cell-permeable NLS peptide as a potential anti-atherosclerotic agent.

225 ascular smooth muscle cells and macrophages, NLS peptide specifically blocked the importin alpha-medi

226 scopy, we demonstrated that NOTP-PGK-GFP and NLS-PGK-GFP are localized in the cytoplasm and nucleus,

227 When NOTP-PGK-GFP and NLS-PGK-GFP are transiently expressed, we observed a red

228 us location mutant (nuclear location signal [NLS]-PGK-GFP).

229 (NLR, PLR, LMR, CAR) and cumulative scores (NLS, PLS, LMS, NPS, mGPS).

230 , unlike NLS1 that associates with the minor NLS-pocket.

231 nce energy transfer (FRET), we show that 627-NLS populates a temperature-dependent dynamic equilibriu

232 nucleus via a nuclear localization sequence (NLS) present on the receptor itself or a ligand it is bo

233 n at 197 (BRMS1(DeltaNLS) which removes both NLS) promoted cytoplasmic localization.

234 IPSE-NLS reduced inflammation but not oxidative stress.

235 The pathogenesis of NLS remains unclear despite extensive clinical and patho

236 calization, and mutation or deletion of both NLS renders CAPN5 exclusively cytosolic.

237 Adding NLS, replacing aspartic acid by glutamic acid residues,

238 This study shows that NLS represents the extreme end of a known inborn error o

239 serine biosynthesis pathway and suggest that NLS represents the severe end of serine-deficiency disor

240 The NLS residues were mutated to alanine using a type A full

241 e conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging

242 nstrating the structural context rather than NLS sequence determines selectivity for isoform 3.

243 emonstrate that pol beta contains a specific NLS sequence in the N-terminal lyase domain that promote

244 The Nurr1 NLS sequence, when fused to green fluorescent protein, l

245 minus encodes a nuclear localization signal (NLS) sequence,MRKTKLAPT, important for import of the pro

246 conservation of nuclear localization signal (NLS) sequences previously identified in herpes simplex v

247 t domain via nuclear localization sequences (NLSs), short amino acids motifs enriched in Lys and Arg

248 e 1 IFN-induced HMGB1 acetylation within the NLS sites.

249 hin two HMGB1 nuclear localization sequence (NLS) sites.

250 V solitons) or envelope quasi-solitons (like NLS solitons).

251 e nucleus via a nuclear localization signal (NLS), specific among keratins, where it bound p27(KIP1)

252 nt that imports nuclear localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

253 the CAT starches were also greater than the NLS starch samples.

254 Native Lotus seed (NLS) starch was independently subjected to two different

255 ffinity to that of the classical monopartite NLSs, such as c-myc and SV40 T-antigen NLSs.

256 RTT-causing mutations overlap with the MeCP2 NLS, suggesting that they may alter nuclear localization

257 NLS2 bind weakly to importin alpha, the two NLSs synergize in the context of the full length NP to c

258 3D(pol) We identify two residues of 3D(pol) NLS, T19 and L21, that are important for the maintenance

259 factor Cebpa and is rescued by reintroducing NLS-tagged beta-actin.

260 Endowed by a C-terminal NLS, TgEB1 resides in the nucleoplasm in interphase and

261 indicate that the CRWN4 carries a functional NLS that interacts with canonic nuclear import machinery

262 3 evolved to recognize topologically complex NLSs that lie next to bulky domains or are masked by qua

263 llin contains a nuclear localization signal (NLS) that binds to importin and is required for its func

264 s an N-terminal nuclear localization signal (NLS) that is critical for capsid routing to the nuclear

265 arries a unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA-bindin

266 ins a bipartite nuclear localization signal (NLS) that targets this effector to plant cell nuclei.

267 fusion assays a nuclear localization signal (NLS) that was mapped to a 23-amino-acid sequence at the

268 f FlbB into the nucleus requires a bipartite NLS, that FlbB localization at the tip requires actin an

269 36-759) reveal two globular domains, 627 and NLS, that form a tightly packed heterodimer.

270 tain intrinsic nuclear localization signals (NLSs): the Ets domain within NRF-2alpha and the NLS with

271 Consistent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localizatio

272 The second NLS (TNPO3), which resides in the matrix (MA) domain, is

273 ormational flexibility therefore enables 627-NLS to bind importin through conformational selection fr

274 nuclear localization of RPW8.2 by adding an NLS to it resulted in resistance to powdery mildew.

275 rescued by the addition of the wild-type FUS NLS to mutant proteins.

276 port of Yki, and that addition of an ectopic NLS to Yki is sufficient to bypass the requirement for M

277 CEBPD through nuclear localization signals (NLS) to activate PRKDC-mediated DNA damage repair in res

278 ssues (ONs) and the adjacent normal tissues (NLs) to select the angiogenic miRNA.

279 used n-butyl alcohol extract of Litchi seed (NLS) to treat prostate cancer PC3, DU145, RM1 and C4-2B

280 ogues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly

281 In addition, NLS treatment significantly decreased cell migration and

282 The role of this NLS was confirmed by fluorescent imaging of wild-type an

283 A potent NLS was found at the C-terminus, which is required for n

284 of Tau by expressing I2 (PP2A) in which the NLS was inactivated by (179)RKR(181) --> AAA along with

285 MRE11-NLS was unable to rescue the xrs2Delta defects in Tel1/A

286 ), in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of

287 uclear presence of aSyn in the nucleus (aSyn-NLS), we found the accumulation of high molecular weight

288 In order to identify the cause of NLS, we conducted a positional-mapping study combining a

289 cohort of 12 unrelated families affected by NLS, we provide evidence that NLS is genetically heterog

290 ing the betalains in lecithin nanoliposomes (NLs), which causes a 76% improvement of betalain colour

291 ine-tyrosine nuclear localization signal (PY-NLS), which has a unique intervening sequence in hunting

292 s bear a well-characterized proline-tyrosine-NLS, which is missing from the dsRBD-NLS.

293 Here, we report the structure of the dsRBD-NLS, which reveals an unusual dsRBD fold extended by an

294 The motif in HSV functioned as a monopartite NLS, while in varicella-zoster virus (VZV) activity requ

295 of 81.6% was obtained in polymer-stabilized NLs with a concentration ratio of 0.3:0.1 (CH:GE).

296 s): the Ets domain within NRF-2alpha and the NLS within NRF-2beta (amino acids 311/321: EEPPAKRQCIE)

297 sportin-3 (TNPO3) recognize two nonclassical NLSs within the cold-inducible RNA-binding protein (CIRB

298 ins a bipartite nuclear localization signal (NLS) within its DNA binding domain and two leucine-rich

299 roliferation, whereas constitutively nuclear nls-YAP5SA accelerates proliferation, in line with the c

300 Cartilage-specific expression of nls-YAP5SA or knockout of Lats1/2 do not increase cartil