ライフサイエンスコーパス: NLS

1 NLS induced a significant decrease in cell viability and

2 NLS induced cell apoptosis and cell cycle G1/S phase arr

3 NLS mutant mice had no gross changes in immunophenotype

4 NLS peptide significantly inhibited lesion development a

5 17-36 nm, with tuneable numbers of up to 240 NLSs.

6 The NRF-2beta NLS contains only two lysine/arginine residues, unlike o

7 We conclude that the NRF-2beta NLS is an unusual but is, nevertheless, a bona fide mono

8 TDP-43-NLS accumulation in retinal cells was counteracted by HS

9 n in the nuclear localization signal (TDP-43-NLS).

10 ormational flexibility therefore enables 627-NLS to bind importin through conformational selection fr

11 The molecular basis of the affinity of 627-NLS for importins remained unclear from these structures

12 nce energy transfer (FRET), we show that 627-NLS populates a temperature-dependent dynamic equilibriu

13 y a tripartite salt bridge involving the 627-NLS interface and the linker, that becomes flexible in t

14 ion studies in nulliparous mice that carry a NLS-lacZ transgene downstream of the Mmp14 promoter reve

15 ne substitution being sufficient to abrogate NLS function and virus growth.

16 trate experimentally that the atypical ADAR1-NLS is bimodular and is formed by the combination of the

17 Adding NLS, replacing aspartic acid by glutamic acid residues,

18 In addition, NLS treatment significantly decreased cell migration and

19 ha, sequence variation at the importin-alpha NLS-binding sites and tissue-specific expression levels

20 nuclear localization of RPW8.2 by adding an NLS to it resulted in resistance to powdery mildew.

21 ignal (NLS) motif, whilst Cry3 lacks both an NLS motif and a protein-protein interaction domain.

22 R1 and its natural ligand, collagen, lack an NLS, DDR1 is present in the nucleus of injured human and

23 which was rescued by the introduction of an NLS onto APLF.

24 mes flexible in the open state, with 627 and NLS dislocating into a highly dynamic ensemble.

25 36-759) reveal two globular domains, 627 and NLS, that form a tightly packed heterodimer.

26 expression between cells expressing CD24 and NLS-CD24 revealed a unique nucCD24 transcriptional signa

27 scopy, we demonstrated that NOTP-PGK-GFP and NLS-PGK-GFP are localized in the cytoplasm and nucleus,

28 When NOTP-PGK-GFP and NLS-PGK-GFP are transiently expressed, we observed a red

29 laser surgery (NLS), laser + medication, and NLS + medication) on 1-year intraocular pressure (IOP) c

30 olecular mechanisms governing nodulation and NLS formation.

31 (NPC) barrier selectivity, Kap traffic, and NLS-cargo release are systematically linked and simultan

32 rmed by fluorescent imaging of wild-type and NLS-mutated pol beta(R4S,K5S) in mouse embryonic fibrobl

33 rtite NLSs, such as c-myc and SV40 T-antigen NLSs.

34 uclear presence of aSyn in the nucleus (aSyn-NLS), we found the accumulation of high molecular weight

35 Three of the elements showed autonomous NLS activity and the fourth served as a nuclear localiza

36 tional tools: how many of the ~500 available NLS motifs are needed to establish infection?

37 eta-propeller, or inserting a linker between NLS and beta-propeller, disrupts specificity for importi

38 We propose NLS1 and NLS2 form a bipartite NLS in trans, which ensures high avidity for importin al

39 f FlbB into the nucleus requires a bipartite NLS, that FlbB localization at the tip requires actin an

40 ic section defining the motif as a bipartite NLS.

41 ion elements defined a new form of bipartite NLS consisting of a triplet of basic residues followed b

42 t receptor, KPNA2, which binds the bipartite NLS in Tpr with nanomolar affinity.

43 minal monopartite NLS and a unique bipartite NLS closer to the C terminus.

44 calization, and mutation or deletion of both NLS renders CAPN5 exclusively cytosolic.

45 n at 197 (BRMS1(DeltaNLS) which removes both NLS) promoted cytoplasmic localization.

46 cohort of 12 unrelated families affected by NLS, we provide evidence that NLS is genetically heterog

47 in three consanguineous families affected by NLS.

48 localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

49 Nuclear-specific expression of CD24 (NLS-CD24) increased anchorage-independent growth in vitr

50 differ from conventional well-characterized NLSs from mammals and yeast.

51 Although a classical NLS and importin alpha/beta mediated nuclear import path

52 ontrast, small terminase exposes a classical NLS at the far C terminus of its helical structure that

53 In addition, we predicted a classical NLS in the third terminase subunit that is partially con

54 g does not affect the transport of classical NLS cargo.

55 3 evolved to recognize topologically complex NLSs that lie next to bulky domains or are masked by qua

56 haracterize the genetic pathways controlling NLS formation in cereals.

57 e fed a high-fat diet), i.p., 0.13 mumol/day NLS peptide administration for 5 weeks attenuated NF-kap

58 DCL4(NLS) functions in a noncanonical siRNA pathway, producin

59 biotic stress correlates with enhanced DCL4(NLS) expression, while hypermethylation of a DCL4 transg

60 t of 21-nucleotide-long "disiRNAs," for DCL4(NLS) isoform-dependent siRNAs, through the nuclear RdDM

61 a DCL4 transgene causes a reduction in DCL4(NLS) expression.

62 using the methylation-state-responsive DCL4(NLS).

63 encoding a nuclear localization signal, DCL4(NLS), is present in Arabidopsis, but DNA methylation nor

64 om all herpesvirus subfamilies, demonstrated NLS function, dissected key residues, and showed functio

65 ke other known importin-alpha:beta-dependent NLSs.

66 nctions of M1 in the presence of a disrupted NLS but also resulted in a strong association of M1 with

67 del showing how Trn1 can recognize the dsRBD-NLS and how dsRNA binding can interfere with Trn1 bindin

68 Here, we report the structure of the dsRBD-NLS, which reveals an unusual dsRBD fold extended by an

69 yrosine-NLS, which is missing from the dsRBD-NLS.

70 This dsRBD-NLS is recognized by the nuclear import receptor transpo

71 Dual NLS motifs are common among transcription factors.

72 omic response occurring in rice roots during NLS formation, 7 days post-treatment (dpt) with auxin, 2

73 enes were not expressed in rice roots during NLS formation.

74 port of Yki, and that addition of an ectopic NLS to Yki is sufficient to bypass the requirement for M

75 ut they nevertheless functioned as efficient NLS motifs both in heterologous transfer assays and in H

76 e required to authenticate, bind, and escort NLS-NCs through NPCs while Ran guanosine triphosphate (R

77 Plaques from NLS-treated mice contained fewer macrophages of pro-infl

78 RBM45 mutants that lack a functional NLS accumulate in the cytoplasm and form TDP-43 positive

79 indicate that the CRWN4 carries a functional NLS that interacts with canonic nuclear import machinery

80 t not 3 or less, can constitute a functional NLS-NoLS; AAP2BR1 and AAP2BR2 play the most influential

81 Functional NLSs, NES, and GSK3-beta-dependent phosphorylation regul

82 rescued by the addition of the wild-type FUS NLS to mutant proteins.

83 d in rosette leaves have an almost identical NLS-binding site.

84 although the two isoforms share an identical NLS-binding groove.

85 ucine-lysine nuclear localization signal (IK-NLS) motif at residues 35-40.

86 ined that srp1 mutants that failed to import NLS-containing proteins (srp1-31 and srp1-55) successful

87 (srp1-49 and srp1-E402Q) were able to import NLS-containing proteins.

88 From 39 genes differentially expressed in NLS-CSU when compared with HCs, 31 (79.48%) were confirm

89 OP reductions, with the largest reduction in NLS group (-6.78 mmHg).

90 h precise knock-in mutations to incapacitate NLS function.

91 Analyses including NLS swapping revealed Progerin did not cause global inhi

92 Thus a Cdk-inhibited NLS goes along with Cdk-inhibited APC/C binding sites in

93 consistent with a requirement for an intact NLS in this interaction.

94 eveals the organization of the intermingling NLSs and NoLSs in AAP2 and provides insights into their

95 IPSE-NLS reduced inflammation but not oxidative stress.

96 th or without pretreatment with IPSE or IPSE-NLS (a mutant of IPSE lacking nuclear localization seque

97 e SR protein substrate and appropriating its NLS for transport.

98 cancer cells expressing K17 mutations in its NLS or NES signals exhibited an increase in levels of nu

99 lication defect of an HSV mutant lacking its NLS motif.

100 V solitons) or envelope quasi-solitons (like NLS solitons).

101 and nucleus due to its nuclear localization (NLS) and export sequences (NES).

102 Moreover, SYNV with M NLS mutations exhibited compromised SIE against wild-typ

103 The resultant M1 triple mutant M(NLS-88R) regained replication efficiency in vitro while

104 Unlike the other M1 triple mutants, M(NLS-88R) replicated more efficiently in vitro and in viv

105 ctron microscope, only the M1 layer of the M(NLS-88R) virion exhibited discontinuous fingerprint-like

106 ascular smooth muscle cells and macrophages, NLS peptide specifically blocked the importin alpha-medi

107 NLS2 revealed NLS2 primarily binds the major-NLS binding site of importin alpha, unlike NLS1 that ass

108 RTT-causing mutations overlap with the MeCP2 NLS, suggesting that they may alter nuclear localization

109 , unlike NLS1 that associates with the minor NLS-pocket.

110 We found a monopartite NLS at the N terminus of large terminase, flanking the A

111 The motif in HSV functioned as a monopartite NLS, while in varicella-zoster virus (VZV) activity requ

112 ion signals (NLS): an N-terminal monopartite NLS and a unique bipartite NLS closer to the C terminus.

113 ffinity to that of the classical monopartite NLSs, such as c-myc and SV40 T-antigen NLSs.

114 MRE11-NLS was unable to rescue the xrs2Delta defects in Tel1/A

115 te that nuclear localization of Mre11 (Mre11-NLS) is able to bypass several functions of Xrs2, includ

116 hat AAP2(144-184) has redundant multipartite NLSs and that any combinations of 4 AAP2BRs, but not 3 o

117 In this model, the mutant NLS (mNLS)-I2 (PP2A) (I2 (PP2A)AA-AAA) was retained in t

118 l (NLS)-conjugated polymersome nanocarriers (NLS-NCs) and studied the NCT mechanism underlying their

119 urthermore, 5-FU increased RAGE and NFkappaB NLS immunostaining in enteric neurons, associated with a

120 n of TNPO1 and TNPO3 with these nonclassical NLSs may regulate the formation of membraneless organell

121 sportin-3 (TNPO3) recognize two nonclassical NLSs within the cold-inducible RNA-binding protein (CIRB

122 R), relevant genes expressed in nonlesional (NLS-CSU) and lesional skin (LS-CSU) and peripheral blood

123 fy and characterize AAV2 AAP (AAP2) nuclear (NLS) and nucleolar (NoLS) localization signals near the

124 The Nurr1 NLS sequence, when fused to green fluorescent protein, l

125 In order to identify the cause of NLS, we conducted a positional-mapping study combining a

126 A colony of NLS mutant mice was successfully generated with precise

127 ue by mapping both intranuclear diffusion of NLS-GFP and recovery of 53BP1-mCherry, a marker for DNA

128 og recapitulates many of the key features of NLS.

129 intracellular proteolysis and the import of NLS-containing proteins.

130 easome localization defect and the import of NLS-containing proteins.

131 fected cells, we employed the interaction of NLS-GFP-MS2 (phage MS2 coat protein) with the modified B

132 2D maps of NLS-GFP recovery times showed no pixel-by-pixel correlat

133 The pathogenesis of NLS remains unclear despite extensive clinical and patho

134 curring in rice roots at different stages of NLS formation: early (1-dpt) and late (14-dpt).

135 0 nm) heterogeneity in the recovery times of NLS-GFP, which is validated against simulated data sets.

136 Our findings expand our understanding of NLS as a disorder of the L-serine biosynthesis pathway a

137 s revealed that both location and potency of NLSs in terminase subunits evolved more rapidly than the

138 NBS1, the individual deletions of PS and one NLS (KRMK) robustly reduced the interaction.

139 ma subjects who underwent a single laser, or NLS intervention, and/or took the same medication for at

140 esent, resulting in 3 different, overlapping NLS motifs; and the NoLS is shared redundantly among the

141 is development and identifies cell-permeable NLS peptide as a potential anti-atherosclerotic agent.

142 The 3D(pol) NLS alanine substitutions of T19 and L21 results in aber

143 3D(pol) We identify two residues of 3D(pol) NLS, T19 and L21, that are important for the maintenance

144 A potent NLS was found at the C-terminus, which is required for n

145 es insights into the nature of the potential NLS and the mechanistic relationship between I2 (PP2A)-i

146 -2 missense allele that disrupts a predicted NLS and lowers the abundance of CRWN4 in the nucleus.

147 mics abrogates nuclear transport, preventing NLS (nuclear localisation signal)-cargo release from Ran

148 The primary NLS is in the nucleocapsid (NC) domain of Gag and binds

149 (775)KKARL functioned as the primary NLS, but (737)KRK and (754)KK also contributed to the nu

150 bidopsis thaliana RPL23aA has eight putative NLSs/NoLSs (pNLSs/NoLSs).

151 We show that the (putative) NLSs of metazoan HsSun2, MmLem2, HsLBR, and HsLap2beta a

152 1q-c were increased in neurons expressing PV.NLS-mC, causing a reduction in the density and size of d

153 ted form of parvalbumin fused to mCherry (PV.NLS-mC) led to a reduction in VEGFD expression and, as a

154 in the cell nucleus, which in the case of PV.NLS-mC can be reversed by nuclear calcium transients tri

155 nuclear targeted version of parvalbumin (PV.NLS-mC) led to a build-up of HDAC4 and HDAC5 in the cell

156 importin-beta family proteins, binds to a PY-NLS(2) sequence motif close to the amino terminus of mat

157 e conclude that HMGB1 is a huntingtin N17/PY-NLS ROS-dependent interactor, and this protein bridging

158 ine-tyrosine nuclear localization signal (PY-NLS) in DJ-1, and we found that nuclear monomeric DJ-1 i

159 ine-tyrosine nuclear localization signal (PY-NLS), which has a unique intervening sequence in hunting

160 the PY-type nuclear localization signal (PY-NLS)/karyopherinbeta2 (Kapbeta2) nuclear import system r

161 Mutating the PY-NLS in Gli or knockdown of Kapbeta2 diminished Gli cilia

162 or of the intervening sequence within the PY-NLS.

163 a cells expressing the ALS-causing FUS R495X NLS mutation, and mislocalization of Sm proteins is RRM-

164 factor Cebpa and is rescued by reintroducing NLS-tagged beta-actin.

165 sor ion scan (PIS) or neutral ion loss scan (NLS), using appropriate class specific lipid standards.

166 (NLR, PLR, LMR, CAR) and cumulative scores (NLS, PLS, LMS, NPS, mGPS).

167 The second NLS (TNPO3), which resides in the matrix (MA) domain, is

168 used n-butyl alcohol extract of Litchi seed (NLS) to treat prostate cancer PC3, DU145, RM1 and C4-2B

169 Native Lotus seed (NLS) starch was independently subjected to two different

170 an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nucleus.

171 s a conserved nuclear localisation sequence (NLS) and nuclear export sequence (NES), suggesting a rol

172 d a bipartite nuclear localization sequence (NLS) and thereby controlled the partitioning of Cdh1 bet

173 y a bipartite nuclear-localization sequence (NLS) located at the C-terminus.

174 te C-terminal nuclear localization sequence (NLS) motifs conserved in H03-IPSE, SKRRRKY, and H06-IPSE

175 nucleus via a nuclear localization sequence (NLS) present on the receptor itself or a ligand it is bo

176 hin two HMGB1 nuclear localization sequence (NLS) sites.

177 t resembles a nuclear localization sequence (NLS).

178 ts N-terminal nuclear localization sequence (NLS).

179 wo different nuclear localization sequences (NLS) on the C terminus provide increased editing efficie

180 wo predicted nuclear localization sequences (NLS) that are located near the C-terminus (amino acids 1

181 eceptors via nuclear localisation sequences (NLSs) and the effect of size on import efficiency.

182 t domain via nuclear localization sequences (NLSs), short amino acids motifs enriched in Lys and Arg

183 ese proteins, a nuclear localization signal (NLS) and an intrinsically disordered linker encode the s

184 that acts as a nuclear localization signal (NLS) and in template binding is also involved in nucleot

185 ins a conserved nuclear localization signal (NLS) at its C-terminus that binds to importin-beta and i

186 ue nonclassical nuclear localization signal (NLS) binding site on KPNA5 that is necessary for efficie

187 of a potential nuclear localization signal (NLS) in the C-terminal region of I2 (PP2A) containing a

188 that contain a nuclear localization signal (NLS) into the nucleus.

189 n sequence, the nuclear localization signal (NLS) is reported to reside between amino acids 255-271,

190 A nuclear localization signal (NLS) knock-out mutant N did not activate NF-kappaB, and

191 ctionality of a nuclear localization signal (NLS) located at the N-terminal region of the foot-and-mo

192 rom a bipartite nuclear localization signal (NLS) located in the tail domain [14].

193 t a monopartite nuclear localization signal (NLS) may reside in the N-terminal lyase domain.

194 e presence of a nuclear localization signal (NLS) motif within the GmHSP40.1 coding sequence, GFP-GmH

195 does possess a nuclear localization signal (NLS) motif, whilst Cry3 lacks both an NLS motif and a pr

196 addition to the nuclear localization signal (NLS) of XPA, importin-alpha4 or/and importin-alpha7 are

197 d in a putative nuclear localization signal (NLS) on the Drosophila melanogaster PER protein.

198 ant lacking the nuclear localization signal (NLS) on the ICP0 gene (0DeltaNLS) is sensitive to inhibi

199 minus encodes a nuclear localization signal (NLS) sequence,MRKTKLAPT, important for import of the pro

200 conservation of nuclear localization signal (NLS) sequences previously identified in herpes simplex v

201 llin contains a nuclear localization signal (NLS) that binds to importin and is required for its func

202 s an N-terminal nuclear localization signal (NLS) that is critical for capsid routing to the nuclear

203 arries a unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA-bindin

204 ins a bipartite nuclear localization signal (NLS) that targets this effector to plant cell nuclei.

205 fusion assays a nuclear localization signal (NLS) that was mapped to a 23-amino-acid sequence at the

206 WSN/33 when its nuclear localization signal (NLS) was disrupted by R101S and R105S substitutions.

207 ), in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of

208 ins a bipartite nuclear localization signal (NLS) within its DNA binding domain and two leucine-rich

209 HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclea

210 preserving the nuclear localization signal (NLS), enhances the decatenation checkpoint and sensitivi

211 e nucleus via a nuclear localization signal (NLS), specific among keratins, where it bound p27(KIP1)

212 he nucleus with nuclear localization signal (NLS)-bearing paralogues in the NMCP1-clade was discounte

213 e, we developed nuclear localization signal (NLS)-conjugated polymersome nanocarriers (NLS-NCs) and s

214 leus to release nuclear localization signal (NLS)-containing cargo from import receptors, and, under

215 otably, the PB2 nuclear localization signal (NLS)-containing domain translocates approximately 90 A t

216 its binding to nuclear localization signal (NLS)-containing proteins that regulate nuclear and spind

217 he nucleus in a nuclear localization signal (NLS)-dependent manner, where it localized to novel F-act

218 nt that imports nuclear localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

219 ions in the FUS nuclear localization signal (NLS).

220 dNTPase) with a nuclear localization signal (NLS).

221 he FMDV 3D(pol) nuclear localization signal (NLS).

222 The functional nuclear location signal (NLS) mapped to 3 clusters of basic residues.

223 us location mutant (nuclear location signal [NLS]-PGK-GFP).

224 with weakened nuclear localization signals (NLS) and deficient nuclear interactions with the SYNV nu

225 CEBPD through nuclear localization signals (NLS) to activate PRKDC-mediated DNA damage repair in res

226 domain and two nuclear localization signals (NLS).

227 possesses two nuclear localization signals (NLS): an N-terminal monopartite NLS and a unique biparti

228 des containing nuclear localization signals (NLSs) 1 and 2 were non-acetylated, and all cysteine resi

229 ora sojae uses nuclear localization signals (NLSs) for translocation of proteins into the nucleus tha

230 wo independent nuclear localization signals (NLSs) in Gag.

231 importins with nuclear localization signals (NLSs) of cargo proteins not only mediates nuclear import

232 rs (NIRs) bind nuclear-localization signals (NLSs) of protein cargo in the cytoplasm and transport th

233 ogues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly

234 ignals and the nuclear localization signals (NLSs), as well as the nuclear export signals (NESs), in

235 es contain two nuclear localization signals (NLSs): a well-studied monopartite NLS1 and a less-charac

236 tain intrinsic nuclear localization signals (NLSs): the Ets domain within NRF-2alpha and the NLS with

237 cids-nuclear/nucleolar localization signals (NLSs/NoLSs).

238 emonstrate that pol beta contains a specific NLS sequence in the N-terminal lyase domain that promote

239 uce the formation of nodule-like structures (NLS) in plant roots even in the absence of bacteria.

240 during formation of nodule-like structures (NLS) in rice and compared rice RNA-seq dataset with a no

241 ments (medication, laser, non-laser surgery (NLS), laser + medication, and NLS + medication) on 1-yea

242 We propose that swapping NLSs among terminase subunits is a regulatory mechanism

243 Neu-Laxova syndrome (NLS) is a rare autosomal-recessive disorder characterize

244 Neu-Laxova syndrome (NLS) is a rare autosomal-recessive disorder characterize

245 l lines that express a fusion protein termed NLS.GFP.SAM595 in which the Vpx binding domain of SAMHD1

246 The C-terminal NLS contains a SUMO-interacting motif that contributes t

247 Retention of the C-terminal NLS in anillin homologues suggests that this is a conser

248 Endowed by a C-terminal NLS, TgEB1 resides in the nucleoplasm in interphase and

249 nstrating the structural context rather than NLS sequence determines selectivity for isoform 3.

250 es affected by NLS, we provide evidence that NLS is genetically heterogeneous and can be caused by mu

251 This study shows that NLS represents the extreme end of a known inborn error o

252 These findings suggest that NLS has potential for development into a safe and potent

253 serine biosynthesis pathway and suggest that NLS represents the severe end of serine-deficiency disor

254 terial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodell

255 The NLS residues were mutated to alanine using a type A full

256 s): the Ets domain within NRF-2alpha and the NLS within NRF-2beta (amino acids 311/321: EEPPAKRQCIE)

257 s NLS of Pom121 adapts a similar fold as the NLS of Heh2 when transport factor bound and rescues the

258 A-GTP binding domain, which autoinhibits the NLS and the neighboring microtubule-binding domain, and

259 tion of a membrane protein in yeast, but the NLS from RnPom121 is.

260 f Vpx-containing virions with the cells, the NLS.GFP.SAM595 fusion protein was degraded over several

261 ility of the nearby C2 domain containing the NLS.

262 tifying the genetic switches controlling the NLS organogenesis program in crops, especially cereals,

263 o wedge the RCC1 beta-propeller flanking the NLS against its lateral surface, preventing steric clash

264 y the virus as a compensatory change for the NLS loss and resultant replication deficiency, three mor

265 tion to R101S and R105S substitutions in the NLS were generated.

266 the entire N-terminal domain, including the NLS, interacted with TCPs but did not destabilize them.

267 A Nurr1 mutant lacking the NLS failed to enter the nucleus.

268 of TAP, whereas an HDAg-L mutant lacking the NLS failed to interact with full-length TAP.

269 Mutating the NLS decreases anillin's cortical affinity, causing it to

270 ent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localization in HEK29

271 t substitutions at residues 18 and 20 of the NLS are defective in proper incorporation of nucleotides

272 stand the role of individual residues of the NLS in nuclear localization and nucleotide incorporation

273 MDV 3D(pol), suggesting that the role of the NLS motif in similar viral polymerases needs to be revis

274 ry for its function, because deletion of the NLS or addition of a nuclear export signal abolished its

275 er and the degree of the double helix of the NLS.

276 2alphabeta becomes strictly dependent on the NLS within NRF-2beta.

277 the CTD of topo IIbeta, while preserving the NLS, and mutation of Y640 in topo IIalpha and Y656 in to

278 ion electron microscopy further resolves the NLS-NCs on transit in NPCs and inside the nucleus.

279 Surprisingly, the NLS-associated locus identified in this study was solved

280 the CAT starches were also greater than the NLS starch samples.

281 R/Cas9 to make inactivating mutations to the NLS on the Il1a gene.

282 rated to bind small domains connected to the NLS.

283 of Tau by expressing I2 (PP2A) in which the NLS was inactivated by (179)RKR(181) --> AAA along with

284 we isolated proteins that interact with the NLS and identified karyopherin alpha 3 (KPNA3 or Kap-alp

285 e 1 IFN-induced HMGB1 acetylation within the NLS sites.

286 Here, we have characterized in depth the NLSs of a P. sojae basic leucine zipper transcription fa

287 The conserved features of the NLSs of ScHeh1, ScHeh2, and RnPom121 and the effective s

288 Consistent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localizatio

289 This NLS of Pom121 adapts a similar fold as the NLS of Heh2 w

290 The role of this NLS was confirmed by fluorescent imaging of wild-type an

291 dependent manner that is directly coupled to NLS-cargo release and NPC barrier function.

292 hat, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.

293 The MP(TVCV) NLS appeared to be conserved in the subgroup 3 tobamovir

294 as an RNA-sensing scaffold, allowing the two NLS modules to be properly positioned for interacting wi

295 NLS2 bind weakly to importin alpha, the two NLSs synergize in the context of the full length NP to c

296 , nevertheless, a bona fide monopartite-type NLS.

297 s bear a well-characterized proline-tyrosine-NLS, which is missing from the dsRBD-NLS.

298 ng enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests tha

299 From the analysis comparing LS-CSU with NLS-CSU, a selection of 142 genes was studied with qPCR,

300 inally, PC3 xenograft nude mice treated with NLS in vivo showed a significant decrease in tumor size