1 out the domain, as determined by (2)H methyl
NMR relaxation.
2 tional molecular dynamics is not detected by
NMR relaxation.
3 different backbone mobility, as monitored by
NMR relaxation.
4 G4T4G4) is slow on the timescale of the 23Na
NMR relaxation.
5 rnal side chain motion that is detectable by
NMR relaxation.
6 h measures of side-chain motion derived from
NMR relaxation.
7 ized using (15)N nuclear magnetic resonance (
NMR) relaxation.
8 Here we show that solid-state (2)H
NMR relaxation allows investigation of light-induced cha
9 (SAXS), dynamic light scattering (DLS), and
NMR relaxation analyses.
10 onditions studied, the order parameters from
NMR relaxation analysis are uniformly high (>0.8) for mo
11 ers, structure-based calculations, and (15)N
NMR relaxation analysis highlights the energetic contrib
12 ents, multiangle light scattering, and (15)N
NMR relaxation analysis indicate that AtraPBP1 forms a s
13 d gradient NMR diffusion experiments and 15N
NMR relaxation analysis indicate that Ca2+-bound DREAM f
14 NMR relaxation analysis revealed that protein dynamics w
15 ysis combined with dynamic measurements from
NMR relaxation and diffusion data provides direct eviden
16 Hydrodynamic parameters from
NMR relaxation and diffusion measurements showed that fA
17 adapted version of H/D exchange experiment,
NMR relaxation and diffusion measurements, dynamic light
18 gnetometers as detectors for ultra-low-field
NMR relaxation and diffusion measurements.
19 NMR relaxation and dispersion experiments compare fast (
20 udies of conformational flexibility from 15N
NMR relaxation and H/D exchange experiments.
21 and RLP2-bound SH3 were performed via (15)N
NMR relaxation and hydrogen-deuterium (H/(2)H) exchange
22 Our
NMR relaxation and hydrogen-deuterium exchange studies t
23 Using (15)N
NMR relaxation and hydrogen/deuterium exchange, we demon
24 ions proposed on the basis of recent elegant
NMR relaxation and line-shape analyses, the energetics o
25 in of Trp102 obtained from the fluorescence,
NMR relaxation and minimum perturbation data are consist
26 in (ABP) with its ligand, d-galactose, using
NMR relaxation and molecular dynamics simulation.
27 T antigens have been investigated using 15N
NMR relaxation and molecular dynamics simulation.
28 an activation energy of 0.28 eV, detected by
NMR relaxation and SAE NMR.
29 d electron spin resonance spectroscopy, (1)H
NMR relaxation,
and (19)F NMR spectroscopy experiments w
30 itration calorimetry, X-ray crystallography,
NMR relaxation,
and molecular dynamics simulations follo
31 re further studied by X-ray crystallography,
NMR relaxation,
and pulse-EPR methods, in conjunction wi
32 ptor-like kinase partner, according to (15)N
NMR relaxation at 11.7 and 14.1 T.
33 o barnase, is investigated with (15)N, (13)C
NMR relaxation at 11.74 and 18.78 T and with a 1.1 ns mo
34 By measuring (15)N
NMR relaxation at different magnetic field strengths, we
35 Quantitative analysis of an array of
NMR relaxation-
based experiments (including Carr-Purcell
36 Unlike solution
NMR relaxation-
based order parameters, order parameters
37 We report a (129)Xe
NMR relaxation-
based sensing approach that exploits chan
38 These results suggest that F- 19F
NMR relaxation can be used to predict the reactivities o
39 nce is much stronger than the case for other
NMR relaxation constants, including the "conventional" r
40 thermore, analyses of the spin-label induced
NMR relaxation corroborates the presence of a discrete t
41 The (15)N
NMR relaxation data ((15)N-T(1), (15)N-T(2), and heteron
42 bling may be determined by analysis of (15)N
NMR relaxation data according to the Lipari-Szabo model
43 al diffusion model is generally required for
NMR relaxation data analysis in single-domain proteins,
44 (15)N
NMR relaxation data and RDCs show that TM is highly orde
45 NMR relaxation data and structural studies of the folded
46 As shown by
NMR relaxation data collected at two fields, several cle
47 This method offers the possibility to use
NMR relaxation data for detailed structure characterizat
48 The interpretation of
NMR relaxation data for macromolecules possessing slow i
49 lography data on the free protein, and (15)N
NMR relaxation data for the uncomplexed and HA(8)-bound
50 Proper analysis of
NMR relaxation data for these systems in solution has to
51 (15)N
NMR relaxation data identify significant motion occurrin
52 ide bases is important for interpretation of
NMR relaxation data in terms of local dynamic properties
53 eloped by Freed and others, we interpret the
NMR relaxation data in terms of localized water translat
54 ynamic properties were determined from (15)N
NMR relaxation data in terms of the extended model-free
55 The 13C
NMR relaxation data indicate substantial dynamic fluctua
56 parameters of polyunsaturated chains and the
NMR relaxation data indicate that both DHA and DPA under
57 structure of this helix is well formed, but
NMR relaxation data indicate that there is considerable
58 (31)P-
NMR relaxation data indicated a change in lipid headgrou
59 ework is presented for the interpretation of
NMR relaxation data of proteins.
60 gs, paramagnetic relaxation enhancement, and
NMR relaxation data of their individual residues.
61 The approach was applied to
NMR relaxation data of ubiquitin collected at multiple m
62 Our analysis of the
NMR relaxation data quantifies subtle changes in the int
63 NMR relaxation data reveal a role for conformational pla
64 dynamics of the three isoforms obtained from
NMR relaxation data reveal that ASCb tumbles as a rod, w
65 NMR relaxation data reveal that the source of the differ
66 Our structural analysis and
NMR relaxation data show that these motifs do not intera
67 Analysis of
NMR relaxation data shows that the chemical exchange exh
68 NMR relaxation data suggest that structural dynamics are
69 n of the novel RED results and corresponding
NMR relaxation data suggests that the loss of collective
70 nt of a peptide sequence, we have used (15)N
NMR relaxation data to characterize the backbone motions
71 Detailed analysis of backbone 15N
NMR relaxation data using both the Lipari-Szabo model-fr
72 namics of eotaxin-3 were determined from 15N
NMR relaxation data using the extended model free dynami
73 NMR relaxation data were analyzed by the model-free appr
74 s, their eigenvalues, and correlation times,
NMR relaxation data were calculated in accordance with B
75 characterized based on an analysis of (15)N
NMR relaxation data which we have interpreted using the
76 ze our simulation trajectories, we reproduce
NMR relaxation data without fitting any parameters of ou
77 (13)C-
NMR relaxation data, analyzed using the model-free forma
78 Comparison of (15)N
NMR relaxation data, reduced spectral density profiles,
79 On the basis of
NMR relaxation data, the alpha2 helix as well as the bet
80 in via a hydrophilic interface and, based on
NMR relaxation data, undergoes inter-domain motions enab
81 etation of dynamics parameters obtained from
NMR relaxation data.
82 near models and the distances implied by the
NMR relaxation data.
83 or 64TC lesions were investigated using 15N
NMR relaxation data.
84 that provide a microscopic interpretation of
NMR relaxation data.
85 the (3)J(NzetaCgamma)-coupling constants and
NMR-relaxation-
derived S(2) order parameters of the NH(3
86 arrowed linewidths, and accurate analysis of
NMR relaxation dispersion (CPMG) and TROSY-based CEST ex
87 NMR relaxation dispersion (RD) spectroscopy based on a C
88 According to (15)N
NMR relaxation dispersion analysis, the slow motion is m
89 By applying a combination of
NMR relaxation dispersion and fluorescence kinetics meth
90 The combination of
NMR relaxation dispersion Carr-Purcell-Meiboom-Gill (CPM
91 ermined from a linear dependence of the (1)H
NMR relaxation dispersion drawn as a function of the squ
92 millisecond dynamics that can by measured by
NMR relaxation dispersion experiments and shows a linear
93 Solution
NMR relaxation dispersion experiments performed under ph
94 Data gathered from
NMR relaxation dispersion experiments show that a subset
95 Here we used
NMR relaxation dispersion experiments to understand the
96 NMR relaxation dispersion experiments with that enzyme s
97 NMR relaxation dispersion experiments, coupled with conc
98 in Pol beta have been determined by solution
NMR relaxation dispersion for the apo and substrate-boun
99 and off-resonance carbon and nitrogen R1rho
NMR relaxation dispersion in concert with mutagenesis an
100 at Carr-Purcell-Meiboom-Gill (CPMG) 13Calpha
NMR relaxation dispersion measurements are a viable mean
101 NMR relaxation dispersion measurements indicate that res
102 NMR relaxation dispersion measurements of millisecond ti
103 ynamics of these states have been studied by
NMR relaxation dispersion measurements of the methyl gro
104 NMR relaxation dispersion measurements report on conform
105 Here we use solid-state
NMR relaxation dispersion measurements with a focus on t
106 Based on these results and pH-dependent
NMR relaxation dispersion measurements, we estimate that
107 Here, we use side-chain proton
NMR relaxation dispersion measurements, X-ray crystallog
108 ysis using the Modelfree approach and by the
NMR relaxation dispersion measurements.
109 rium exchange mass spectrometry (HDX-MS) and
NMR relaxation dispersion measurements.
110 ange broadening effects (R(ex)) as probed by
NMR relaxation dispersion measurements.
111 We recently used
NMR relaxation dispersion methods and computational tech
112 apture key properties previously measured by
NMR relaxation dispersion methods including the structur
113 NMR relaxation dispersion methods provide a holistic way
114 ropose a quantitative method to analyse (1)H
NMR relaxation dispersion profiles based on a model-free
115 Studies employing
NMR relaxation dispersion recently showed that wobble dG
116 Here, using
NMR relaxation dispersion spectroscopy and mutagenesis,
117 In the present work,
NMR relaxation dispersion spectroscopy is used to direct
118 ogical function, as demonstrated by numerous
NMR relaxation dispersion studies.
119 We applied
NMR relaxation dispersion to investigate the role of bou
120 Here we use
NMR relaxation dispersion to probe conformational exchan
121 NMR relaxation dispersion, chemical exchange saturation
122 Here, using
NMR relaxation dispersion, including a new strategy for
123 In this study, we use a combination of
NMR relaxation dispersion, model-free analysis, and liga
124 Using
NMR relaxation dispersion, we have measured the temperat
125 Using
NMR relaxation dispersion, we show here that wobble dG*d
126 ed with intrinsic millisecond dynamics using
NMR relaxation dispersion.
127 approach between experimental high-pressure
NMR relaxation during catalysis and molecular dynamics s
128 the contacts in detail, we used paramagnetic
NMR relaxation enhancements, in combination with single-
129 A ligand-observed (1)H
NMR relaxation experiment is introduced for measuring th
130 13C-
NMR relaxation experiments (T(1), T(2), T(1)(rho), and N
131 NMR relaxation experiments and molecular dynamics simula
132 NMR relaxation experiments and other biophysical measure
133 and side-chain order parameters derived from
NMR relaxation experiments are in excellent agreement wi
134 NMR relaxation experiments clarified the hypothesis abou
135 (19)F
NMR relaxation experiments employing an active-site inhi
136 Solution
NMR relaxation experiments identify a cluster of residue
137 NMR relaxation experiments indicated that a flexible loo
138 NMR relaxation experiments indicated that the peptide wa
139 (15)N
NMR relaxation experiments of the (15)N-labeled recombin
140 NMR relaxation experiments often require site-specific i
141 Two-dimensional 1H-15N
NMR relaxation experiments on [alpha-15N]histidine-label
142 We identify, through
NMR relaxation experiments recorded on the unfolded doma
143 NMR relaxation experiments reveal that HisJ becomes more
144 Recent
NMR relaxation experiments revealed the transient presen
145 NMR relaxation experiments sensitive to motions of methy
146 (15)N
NMR relaxation experiments show that PTB1:34 has slow, m
147 Complementary cross-linking and
NMR relaxation experiments show that the OmpA beta-barre
148 The kinetics and
NMR relaxation experiments suggest that the weak binding
149 Moreover, we carry out
NMR relaxation experiments to characterize the picosecon
150 We have used
NMR relaxation experiments to determine the molecular ba
151 We have used (13)C
NMR relaxation experiments to examine changes in the mot
152 In this study, we used 15N
NMR relaxation experiments to probe the fast (i.e., ps-n
153 were obtained for a set of IDPs by solution
NMR relaxation experiments, are explained here by a firs
154 In addition, by using (15)N
NMR relaxation experiments, we find that binding ubiquit
155 Furthermore, using (15)N
NMR relaxation experiments, we show that, in the mutant
156 ributions to side-chain dynamics measured by
NMR relaxation experiments.
157 and during catalysis were characterized with
NMR relaxation experiments.
158 monitored by hydrogen/deuterium exchange and
NMR relaxation experiments.
159 sin inhibitor (BPTI) were examined using 15N
NMR relaxation experiments.
160 and two-dimensional (1)H-(15)N heteronuclear
NMR relaxation experiments.
161 ired mobility by both molecular dynamics and
NMR relaxation experiments.
162 Nuclear magnetic resonance (
NMR) relaxation experiments show that TF interacts with
163 the combined system simultaneously measured
NMR relaxation from multiple samples and resolved spectr
164 Most theoretical models for
NMR relaxation in liquids assume that overall rotational
165 NMR relaxation indicates compensatory changes in loop fl
166 obility gradient similar to that observed in
NMR relaxation,
indicating that side chain motions mirro
167 NMR relaxation is increasingly used to detect conformati
168 H-H exchange measured by
NMR relaxation is limited to the study of small rapidly
169 NMR relaxation is used here to monitor the effects of hi
170 hly dynamic and mostly extended according to
NMR relaxation measurements and analytical ultracentrifu
171 ex with DNA have been characterized by (15)N
NMR relaxation measurements and model-free analysis.
172 ere investigated at 30 degrees C using (15)N
NMR relaxation measurements and NMR monitored hydrogen-d
173 Interestingly,
NMR relaxation measurements and the results of a model b
174 ely) of carboxyl side chains, based on (13)C
NMR relaxation measurements as a function of pH.
175 analogue were determined from heteronuclear
NMR relaxation measurements at similar solution conditio
176 Historically,
NMR relaxation measurements have played a dominant role
177 NMR relaxation measurements have suggested that changes
178 By use of heteronuclear (15)N
NMR relaxation measurements in a series (n = 1-6) of (15
179 ned rotational diffusion tensor derived from
NMR relaxation measurements in macromolecular structure
180 NMR relaxation measurements indicate that the exchange r
181 NMR relaxation measurements of 15N spin-lattice relaxati
182 motion was investigated by 1H, 13C, and 15N
NMR relaxation measurements on a DNA decamer d(CATTTGCAT
183 (2)H
NMR relaxation measurements revealed an additional water
184 (15)N
NMR relaxation measurements show that full-length HMGB1
185 Here we use
NMR relaxation measurements to address the kinetics of e
186 Here we use
NMR relaxation measurements to explore the role of the l
187 hydroxylation and epoxidation, paramagnetic
NMR relaxation measurements were conducted.
188 lectron spin resonance spectroscopy and (1)H
NMR relaxation measurements, including spin-lattice rela
189 23Na
NMR relaxation measurements, performed as a function of
190 w temperature as identified by heteronuclear
NMR relaxation measurements, secondary chemical shifts,
191 ating those that could be obtained from (1)H-
NMR relaxation measurements, were calculated between lig
192 were investigated using backbone amide (15)N-
NMR relaxation measurements.
193 ith a long insertion shown to be flexible by
NMR relaxation measurements.
194 ts (CTPR2 and CPTR3, respectively) using 15N
NMR relaxation measurements.
195 st equivalent of metal through heteronuclear
NMR relaxation measurements.
196 al ensemble previously derived from SAXS and
NMR relaxation measurements.
197 ains on a fast timescale was confirmed using
NMR relaxation measurements.
198 namics of TRX(HE) were investigated by (15)N
NMR relaxation measurements.
199 ts, PrP(29-231) and PrP(90-231), using (15)N
NMR relaxation measurements.
200 m B. fragilis have been examined using (15)N
NMR relaxation measurements.
201 bound form of Bcl-x(L) was investigated from
NMR relaxation measurements.
202 idaredoxin (Pdx) have been studied by 2D 15N
NMR relaxation measurements.
203 scale were compared with those obtained from
NMR relaxation measurements.
204 nidulans flavodoxin at pH 6.6, 303 K by 15N
NMR relaxation measurements.
205 ligands, which are less commonly analyzed by
NMR relaxation measurements.
206 ing experimental nuclear magnetic resonance (
NMR) relaxation measurements at atomic resolution combin
207 By combining solution
NMR relaxation methods and (15)N-dark-state exchange sat
208 Here,
NMR relaxation methods for characterizing thermal motion
209 of the RNA in the loop and in the stem, 13C
NMR relaxation methods have been used to describe the dy
210 es sampled during enzymatic reactions, while
NMR relaxation methods reveal the rates of interconversi
211 the unfolded monomer for each variant using
NMR relaxation methods revealed that all variants contai
212 Toward this end, we present new
NMR relaxation methods that describe ligand flexibility
213 Here, we have used mutagenesis and
NMR relaxation methods to investigate the scope and natu
214 combine high resolution field-cycling (31)P
NMR relaxation methods with spin-labeled proteins to del
215 ic group-bearing proteins studied with these
NMR relaxation methods, the side chains of oxidized flav
216 hey become invisible to traditional solution
NMR relaxation methods.
217 in the enzyme dihydrofolate reductase using
NMR relaxation methods.
218 hich has not been previously investigated by
NMR relaxation methods.
219 ht chain kinase is examined using 15N and 2H
NMR relaxation methods.
220 gated using (15)N amide and deuterium methyl
NMR relaxation methods.
221 eptide complex using site-specific deuterium
NMR relaxation methods.
222 second aromatic-ring dynamics using solution
NMR relaxation methods.
223 Several lines of evidence, including (15)N
NMR relaxation,
NMR chemical shift perturbations, static
224 Results of ligand docking and heme-induced
NMR relaxation of drug protons showed that ticlopidine w
225 latus ferrocytochrome c(2) derived from (2)H
NMR relaxation of methyl group resonances is presented.
226 elaxivity (i.e., its ability to speed up the
NMR relaxation of nearby water molecules).
227 amplitudes of the vibrations, as measured by
NMR relaxation or crystallographic B-factors, remain lar
228 Measurement of (15)N
NMR relaxation parameters and backbone hydrogen/deuteriu
229 Agreement between
NMR relaxation parameters and our theoretical results hi
230 behavior of individual domains by measuring
NMR relaxation parameters and residual dipolar couplings
231 The
NMR relaxation parameters are primarily sensitive to rot
232 filtration has allowed the determination of
NMR relaxation parameters at an unprecedented number of
233 Model-free analysis of the
NMR relaxation parameters indicated significantly greate
234 Comparison of the (15)N
NMR relaxation parameters of the holo-TrpRs with those o
235 ual structure in the intermediate state, and
NMR relaxation parameters T(1) and T(2) and inverted que
236 Here,
NMR relaxation parameters were acquired for backbone 15N
237 (15)N and (13)C
NMR relaxation parameters were measured for both peptide
238 The results showed that the
NMR relaxation parameters, rarely used for benchmarking,
239 erase by recording an extensive set of (13)C
NMR relaxation parameters.
240 protein, as indicated by the analysis of the
NMR relaxation parameters.
241 ) of this oligomer have been determined from
NMR relaxation parameters.
242 -3' sequence steps have been determined from
NMR relaxation parameters.
243 r-dynamics simulations and by characteristic
NMR relaxation parameters.
244 Using solid-state (2)H
NMR relaxation performed on selectively deuterated methy
245 olactin were investigated by analysis of 15N
NMR relaxation phenomena and demonstrated a rigid four-h
246 The (15)N
NMR relaxation profiles of apo-L75F-TrpR were analyzed a
247 Here we introduce an approach to making the
NMR relaxation properties of large proteins amenable to
248 alytical expressions for protein motions and
NMR relaxation properties that can be accurately applied
249 ions and dynamics because of their favorable
NMR relaxation properties, which lead to sharp signals i
250 ures of disordered proteins and experimental
NMR relaxation properties.
251 (PH) domain from dynamin were studied by 15N
NMR relaxation (
R1 and R2) and steady state heteronuclea
252 bindin D(9k) have been characterized by (2)H
NMR relaxation rate measurements.
253 ) was determined from its effect on the T(2)
NMR relaxation rate of either phosphite (HPO(3)(2-)) or
254 Measurement of
NMR relaxation rate of water protons in heating-cooling
255 hibit an ex vivo nuclear magnetic resonance (
NMR) relaxation rate (1/T2) as high as 24-39 s-1/mM iron
256 NMR relaxation rates ( (15)N R 1, R 2) and (1)H- (15)N h
257 Moreover, the (2)H
NMR relaxation rates are increased by the presence of om
258 zene off rate and apo protein slow-timescale
NMR relaxation rates between ground and excited states.
259 residue topology was probed by measuring 19F
NMR relaxation rates for site-specifically labeled sampl
260 The paramagnetic enhancements in the
NMR relaxation rates for the fluorine in fluorophthalate
261 ISL by analyzing the power dependence of 13C
NMR relaxation rates in the rotating frame.
262 onstrate that intermoment distances based on
NMR relaxation rates provide a sensitive indicator of in
263 distance, but the distances deduced from the
NMR relaxation rates were shorter than expected for ever
264 , predictions for the amide hydrogens of the
NMR relaxation-
restrained ensemble that become exposed t
265 alysis of protein backbone dynamics based on
NMR relaxation reveals a combination of complementary ef
266 We conducted solid-state (2)H
NMR relaxation (
spin-lattice, T(1Z), and quadrupolar-ord
267 NMR relaxation studies are capable of providing "long-ra
268 NMR relaxation studies are well suited for examining cha
269 31P
NMR relaxation studies from 0.005 to 11.7 T are used to
270 Previous
NMR relaxation studies have identified exchange line bro
271 dynamic was anticipated by previous solution
NMR relaxation studies in micelles, these measurements i
272 Here, we report (13)C
NMR relaxation studies of base and ribose dynamics for t
273 NMR relaxation studies of the complex were carried out a
274 Previous
NMR relaxation studies of the isolated RNase H domain of
275 ng 1855 order parameters from 20 independent
NMR relaxation studies on proteins whose three-dimension
276 15N
NMR relaxation studies reveal that the two zinc knuckle
277 For the first time,
NMR relaxation studies show that the viscoelastic proper
278 Previously, we showed through
NMR relaxation studies that binding of the RA-GEF2 C-ter
279 Described here are 15N
NMR relaxation studies to compare the backbone dynamics
280 NMR relaxation studies were conducted to investigate the
281 ntrifugation, size-exclusion chromatography,
NMR relaxation studies, dynamic light scattering, and ci
282 Using
NMR relaxation studies, the dynamics of the backbone nit
283 xistence of this network comes from previous
NMR relaxation studies, where motions in several residue
284 with data from fluorescence polarization and
NMR relaxation studies.
285 Herein we report a
NMR relaxation study [(1)H and (13)C T(1), T(2); (13)C{(
286 Here, we report an
NMR relaxation study of dynamics over multiple timescale
287 bilayers and detergent micelles by solution
NMR relaxation techniques.
288 Longitudinal (1)H(2)O
NMR relaxation time constant (T(1)) values were measured
289 conditions were also studied by 23Na and 7Li
NMR relaxation time measurements.
290 the experimentally determined dielectric and
NMR relaxation time scales.
291 ng amide hydrogen-deuterium exchange and 15N
NMR relaxation times (T1 and T2) and 15N inverted questi
292 (1)H
NMR relaxation times (T1 and T2) were measured at low fi
293 (13)C-[(1)H]
NMR relaxation times and steady-state NOE enhancements w
294 by analysis of the power dependence of (13)C
NMR relaxation times in the rotating frame (T(1)(rho)).
295 receptor substrate-1 (IRS-PTB), we have used
NMR relaxation to determine the dynamics of backbone ami
296 We used low-field
NMR relaxation to investigate CO2 and water interactions
297 This novel approach yields (19)F T2
NMR relaxation values of any fluorinated contaminant, wh
298 Nitrogen-15 backbone and carbon-13 methyl
NMR relaxation was measured to investigate the dynamical
299 NMR relaxation was used to probe motion on the backbone
300 h measurement of enzyme kinetics, main chain
NMR relaxation,
X-ray crystallographic studies, and in v