ライフサイエンスコーパス: NMR structure

1 hylline complex, as observed in the previous NMR structure.

2 acy and in terms of precision, with a recent NMR structure.

3 conformation similar to the high temperature NMR structure.

4 90 degrees) from the groove predicted by the NMR structure.

5 HSQC chemical shift perturbations to our new NMR structure.

6 ly identified in the CD247 TM dimer solution NMR structure.

7 n these quadruplex crystal structures and an NMR structure.

8 tif in the disordered NS5A-D2 and report its NMR structure.

9 power compared to conventionally determined NMR structures.

10 lates for KCNQ1 homology-modeling) and KCNE1 NMR structures.

11 erver, a quality assessment tool for protein NMR structures.

12 in 1-2 A backbone RMSD relative to X-ray and NMR structures.

13 erent local sequence contexts in crystal and NMR structures.

14 lies in the pore of the crystallographic and NMR structures.

15 ssing and the same interhelix contacts as in NMR structures.

16 howing differences with previously described NMR structures.

17 Also predicted from the NMR structures, a G2S mutant was found to relieve these

18 The solution NMR structure also revealed a novel Cu-binding architect

19 The NMR structures also show that the Pab PolII intein has a

20 erior locations that bind rimantadine in the NMR structure, although these sites are partially due to

21 In this work, NMR structure analysis of 10 permethylated polysaccharid

22 High-resolution NMR structure analysis of AVR3a indicates that the RxLR

23 ncepts herein developed will thus facilitate NMR structure analysis of insoluble plant cell wall poly

24 chemical shift data is shown to be vital for NMR structure analysis of minor polysaccharide component

25 We present the solution NMR structure and conformational dynamics of the 59 nucl

26 Here we describe the NMR structure and dynamics of Ca(2+)-bound PC2-EF.

27 closely with the interfaces observed in the NMR structure and inferred from mutational analysis of d

28 tational analysis of Yhc1, guided by the U1C NMR structure and low-resolution crystal structure of hu

29 We determined the solution NMR structure and studied the dynamics of medaka P2ab, a

30 The NMR structure and the cryo-EM density envelope were comb

31 nctional 120b pRNA was generated using a 27b NMR structure and the crystal structure of the 66b prohe

32 ectrum and 2) to solve its three-dimensional NMR structure and thus gain insight into structure-funct

33 The NMR structures and Autodock analysis suggest that the po

34 deviate somewhat from previously determined NMR structures and indicate that very minor structural c

35 bed here can improve the accuracy of protein NMR structures and should find broad and general for stu

36 finement of their X-ray crystal and solution NMR structures and the characterization of structural an

37 hin 1 A rmsd of the traditionally determined NMR structure, and fit independently collected RDC data

38 f proteins better than individual crystal or NMR structures, and can suggest experimentally testable

39 tructures; decoy structures generated for 89 NMR structures; and conventional predictors of accuracy

40 , and 12 experimentally determined X-ray and NMR structures are nearly identical to the computational

41 es are typically too rigid in loops, whereas NMR structures are typically too floppy overall.

42 antially, irrespective of using a crystal or NMR structure as the starting conformation.

43 in the available (but membrane-free) crystal/NMR structures as pointing away from the membrane (helix

44 ctural order of the beta2-alpha2 loop in the NMR structure at pH 4.5 and 20 degrees C, caused transmi

45 m a well-structured beta2-alpha2 loop in the NMR structures at 20 degrees C termed rigid-loop cellula

46 Here we describe the solution NMR structure, backbone dynamics, and heme binding prope

47 Subsequent NMR structure-based mutational analysis of the region hi

48 Together with classical automated NMR structure calculation, this allowed us to faithfully

49 However, NMR structure calculations typically use a simple repuls

50 t inclusion of (15)N R(2)/R(1) restraints in NMR structure calculations without any a priori assumpti

51 erdeuterated samples to guide RASREC Rosetta NMR structure calculations.

52 Moreover, the NMR structure can guide rational design of ligands that

53 Finally, the static alpha3Y NMR structure cannot explain (i) how the phenolic proton

54 and a tool for interactive visualization of NMR structures, corresponding experimental data as well

55 lacement, such information is rarely used in NMR structure determination because it can be incorrect,

56 The pK(a) coupling and NMR structure determination demonstrate that protonated

57 han 15 kilodaltons and should enable routine NMR structure determination for larger proteins.

58 NMR structure determination further reveals that despite

59 tomic-level structural data, and, generally, NMR structure determination is restricted to small (<30

60 lication as weak-alignment media in solution NMR structure determination of membrane proteins in dete

61 th identical solution conditions as used for NMR structure determination or for crystallization trial

62 ilable at the early stage of the traditional NMR structure determination process, before the collecti

63 Conventional NMR structure determination requires nearly complete ass

64 NMR structure determination reveals a symmetric dimer in

65 NMR structure determination reveals that J2a/b forms a d

66 ar masses up to 15.4 kDa, whose conventional NMR structure determination was conducted in parallel by

67 nd binding studies with peptide mutagenesis, NMR structure determination, and molecular modeling, we

68 ), residue two in our CTD construct used for NMR structure determination, but not present in the crys

69 tag was required to get spectra suitable for NMR structure determination, while the tag was required

70 Despite the advances in NMR, structure determination is often slow and constitut

71 This work reports NMR structure determinations of the C-terminal domain (S

72 Finally, NMR structure determinations suggested that MTP1 would b

73 auser effect restraints, greatly simplifying NMR structure determinations.

74 NMR structures display more variability, but is this bec

75 lar to the crystal structure of apoE-NT, the NMR structure displayed an elongated four-helix bundle.

76 ll-converged and stably folded nature of the NMR structure ensemble, experimentally resolved intermol

77 The NMR structure exhibits an excellent agreement with the d

78 athematical rigidity theory, calculated from NMR structures [FIRST], using a correlation score (which

79 In this study, we present an NMR structure for the entire EAG domain, which reveals t

80 Here we present liposome fusion data and NMR structures for a complete (54-residue) disulfide-bon

81 utine determination of high-quality solution NMR structures for proteins up to 40 kDa, and should be

82 Here, we present the NMR structures for the two lobes of CaM each bound to a

83 in the middle of the channel, whereas in the NMR structure four drug molecules bind at the channel's

84 eomics Project; and (iii) static crystal and NMR structures from the Protein Data Bank.

85 ies with a NaV1.7 homology model and peptide NMR structure generated a model consistent with the key

86 Using NMR structure-guided mutagenesis, electrophoretic mobili

87 To confirm the NMR structure in a membrane-like environment, we studied

88 this controversy by determining the de novo NMR structure in near-native lipid bilayers, and by acce

89 in Escherichia coli We determined citrocin's NMR structure in water and found that is reminiscent of

90 NMR structures in dodecylphosphocholine micelles at pH 7

91 ant differences from the previously reported NMR structures in some regions of the ShK protein molecu

92 Our NMR structures indicated that the different thermostabil

93 al flexibility (derived from the ensemble of NMR structures), interhelical hydrogen bonds, and native

94 In contrast, the NMR structure is based on a peptide/micelle construct th

95 structure-like packing in the core, but more NMR-structure-like variability in loops, may in some cas

96 insight into its function, we determined the NMR structure of (Ba)SrtA bound to a LPXTG sorting signa

97 The NMR structure of 1 demonstrated that compound 1 retained

98 The NMR structure of [betaCpe(34)]-NPY-(25-36) in dodecylpho

99 The solution-NMR structure of a 15-kDa biologically active C-terminal

100 ng of XPA to ERCC1 derives from the solution NMR structure of a complex between the ERCC1 central fra

101 The NMR structure of a complex of Pex5-(57-71) with the Pex1

102 We additionally determined a solution NMR structure of a divergent fungal homolog, and compari

103 We report here the NMR structure of a domain IIa construct in complex with

104 i formation, we have determined the solution NMR structure of a double mutant of CsgE (W48A/F79A) tha

105 The solution state NMR structure of a peptide comprising the LD anchor boun

106 The NMR structure of a peptide-RNA complex reveals that thes

107 The recent NMR structure of a PLN pentamer depicts cytoplasmic heli

108 Together with the recently published NMR structure of a UCP family member, our data provide a

109 Here, we extend our recent findings on the NMR structure of A3A and report structural, biochemical

110 Here we report solution NMR structure of an 11-kDa BRCA1 C-terminus (BRCT) domai

111 Although an NMR structure of an engineered proinsulin monomer has be

112 ur knowledge, the first magic-angle spinning NMR structure of an intact filamentous virus capsid and

113 This structure represents the first NMR structure of an intercalated RNA duplex, of either b

114 The NMR structure of an OCRE-SmN peptide complex reveals a s

115 We report the NMR structure of apoE3, displaying a unique topology of

116 The NMR structure of AtraPBP1 at pH 4.5 contains seven alpha

117 The high-resolution NMR structure of C-terminal domains III and IV of the AU

118 Here we present the NMR structure of Ca(2+)-CaM bound to two molecules of ER

119 Here, we present the NMR structure of CaM bound to MA-(8-43).

120 Here, the NMR structure of CBP reveals a highly intertwined homodi

121 nliganded GAF-A with the previously reported NMR structure of cGMP-bound PDE5 revealed dramatic confo

122 The three-dimensional NMR structure of chicken AvBD2 defensin displays the str

123 The NMR structure of CshA_RD13 revealed a hitherto unreporte

124 Here, we present the solution NMR structure of CUG-binding protein 2 RRM3 in complex w

125 The NMR structure of Dph4 reveals two domains: a conserved J

126 We describe the NMR structure of DsbB, a polytopic helical membrane prot

127 The NMR structure of Dtrx shows a different charge repartiti

128 Comparison of the NMR structure of free FluA with the X-ray structures of

129 Here, we report the NMR structure of full-length PriC from Cronobacter sakaz

130 ck-calculated RDCs using the high-resolution NMR structure of GlyR TM23 in trifluoroethanol as the st

131 The NMR structure of gp6 reveals a dimeric protein with a he

132 The 2D (1)H-NMR structure of HB10 revealed a beta-hairpin loop stabi

133 The NMR structure of HlyIIC reveals a novel fold, consisting

134 ween amylin and membranes, we determined the NMR structure of human amylin bound to SDS micelles.

135 Klebsiella oxytoca, obtained by fitting the NMR structure of its calcium-bound subunit PulG into the

136 Here we report the NMR structure of its kringle domain, NT/K.

137 We solve the NMR structure of its transmembrane domain in micelles an

138 sulfate as a membrane model, we examined the NMR structure of K2 in the presence and absence of the m

139 However, a solution NMR structure of M2(18-60) showed four rimantadines boun

140 We have solved the solution NMR structure of micelle-bound syntaxin-1A in its prefus

141 The solution NMR structure of MLL4-PHD6 in complex with a H4K16ac pep

142 The NMR structure of n-NafY reveals that it belongs to the s

143 Here, we report the high resolution NMR structure of N-terminal truncated ComGC revealing a

144 invisible in a previously published solution NMR structure of OmpG in n-dodecylphosphocholine micelle

145 An NMR structure of one of our most promising compounds was

146 ectrophoretic mobility shift assays, and our NMR structure of phosphomimetic T112D Lsr2 suggests that

147 Here we report the solution NMR structure of PopZ(Delta134-177), a truncated form of

148 The NMR structure of RD3 presented here provides a structura

149 The NMR structure of RD3 was validated by mutagenesis.

150 olecular docking simulations using a refined NMR structure of rho-TIA, we identified 14 residues on t

151 Our study describes for the first time a NMR structure of SCP-2 in lepidopteran H. armigera and r

152 The NMR structure of Sdh5 represents the first eukaryotic st

153 The NMR structure of SrtA has been determined with a backbon

154 The three-dimensional NMR structure of Synechococcus OS-B' cyanobacterial Phy

155 The NMR structure of Tah1 has been solved, and this structur

156 his gap in our knowledge, we have solved the NMR structure of the 10th complement type repeat of huma

157 The NMR structure of the 21 kDa lipocalin FluA, which was pr

158 The NMR structure of the 34 -kDa ternary complex of the RNA

159 Here, the three-dimensional NMR structure of the 36-amino acid NCR044 peptide was so

160 The NMR structure of the [3]catenane was determined, suggest

161 We report the NMR structure of the [W184A/M185A]-CTD mutant in its mon

162 Here, we report the NMR structure of the actin-binding domain contained in t

163 We present here the NMR structure of the agonist 12-HHT in its BLT2-bound st

164 The solution NMR structure of the alpha-helical integral membrane pro

165 We also present the solution NMR structure of the antagonist SinI dimer and probe the

166 A previous study showed only the NMR structure of the AP2/ERF domain of AtERF100 in compl

167 Here, we report the solution NMR structure of the autoinhibitory domain of WNK1 (WNK1

168 The differences of the current solid-state NMR structure of the bilayer-bound M2TMP from the deterg

169 Determining the NMR structure of the C. glabrata Gal11A KIX domain provi

170 tubular assembly of CA and a high-resolution NMR structure of the CA C-terminal domain (CTD) dimer.

171 Here we report the NMR structure of the CCHF virus Gn cytoplasmic tail, res

172 The NMR structure of the chicken CD3epsilondelta/gamma heter

173 We report here a high-resolution NMR structure of the complete receptor-binding domain of

174 An NMR structure of the complex between the CXCL12 dimer an

175 Here, we present an NMR structure of the complex of PI4KB and its interactin

176 nalyze biophysical properties and report the NMR structure of the complex of the C-terminal tandem he

177 in into a well-defined conformation, and the NMR structure of the complex shows the drug bound in the

178 Here we report the solution NMR structure of the core ILK.PINCH complex (28 kDa, K(D

179 In the recent solution NMR structure of the DAP12-NKG2C immunoreceptor transmem

180 We determined the NMR structure of the dGMP-fill-in PDGFR-beta vG4 in K(+)

181 We solved the NMR structure of the DNA-binding Myb domain of TbTRF, wh

182 We report a magic angle spinning (MAS) NMR structure of the drug-resistant S31N mutation of M21

183 We now report the three-dimensional NMR structure of the ECD1 of human CRF-R1 complexed with

184 ximately 45 degrees from that observed in an NMR structure of the Escherichia coli LpoA N domain.

185 ittle is known about its structure beyond an NMR structure of the extreme C-terminus, which is known

186 Here, we present a high resolution solution NMR structure of the free form of the MptpA LMW-PTP.

187 Here, we have determined the NMR structure of the functional AbbA dimer, confirmed th

188 We report the NMR structure of the G-quadruplex formed by the conserve

189 In this study, we report a high-resolution NMR structure of the G-rich element within the KRAS NHE.

190 Here, we report the 3D NMR structure of the Helianthus annuus PawS1 (preproalbu

191 al screening based on the recently published NMR structure of the hGlyR-alpha1 transmembrane domain (

192 d from molecular dynamics simulations of the NMR structure of the hGlyR-alpha1 transmembrane domain i

193 We report the solution NMR structure of the hLARP7 CTD and show that this domai

194 tural information available was the solution NMR structure of the inactive calcium-free form of the p

195 Here, we determined an NMR structure of the isolated C-terminal domain of the A

196 We have determined the solution NMR structure of the K-turn sequence element within the

197 We determined the NMR structure of the kindlin-2 PH domain bound to the he

198 The solution NMR structure of the Kluyveromyces lactis pseudoknot, pr

199 to IGF-1 site 1, a finding supported by the NMR structure of the less active Asp-58-IGF-1 variant.

200 The NMR structure of the macrocyclic peptide overlays well w

201 l shift differences relative to the solution NMR structure of the monomer, and mutagenesis.

202 mography structure of an Env "spike" and the NMR structure of the MPER-transmembrane segment.

203 ure overall resembles the recently published NMR structure of the murine cytomegalovirus homolog pM50

204 Here we present the NMR structure of the murine leukaemia virus recoding sig

205 Here, we report the NMR structure of the N-terminal domain (residues 1-74, c

206 The new NMR structure of the Pdx-CYP101 complex agrees well with

207 The NMR structure of the peptide establishes that there is n

208 Here, we report the high resolution solution NMR structure of the PilA protein from G. sulfurreducens

209 The 3-dimensional NMR structure of the purified Gga-AvBD11 is a compact fo

210 ructures are similar to that observed in the NMR structure of the rat skeletal overlap complex.

211 Our recent study established the NMR structure of the recombinant bAalpha406-483 fragment

212 Here we report the NMR structure of the recombinant LP2086 variant B01, a r

213 Here we present the NMR structure of the reduced form of Cr-TRP16, along wit

214 The NMR structure of the resulting mutant reveals significan

215 The NMR structure of the severe acute respiratory syndrome c

216 The NMR structure of the SUMO-2.phospho-RAP80 complex reveal

217 rotein and TER domains, including a solution NMR structure of the Tetrahymena pseudoknot.

218 In this study, we have determined the NMR structure of the three individual R-modules from Alg

219 A solution NMR structure of these compounds bound to tubulin shows

220 ese observations, we determined the solution NMR structure of TRTK12 in a complex with Ca 2+-loaded S

221 The solution-NMR structure of VG16KRKP in lipopolysaccharide features

222 The NMR structure of XlePABP2-TRP revealed that the protein

223 oposed sst(1) pharmacophore derived from the NMR structures of a family of mono- and dicyclic undecam

224 Previously, we reported the NMR structures of Ac-18A-NH(2) (renamed as 2F because of

225 s flexibility has been observed in X-ray and NMR structures of acyl carrier proteins attached to diff

226 Together with NMR structures of amylin and the IGF and epidermal growt

227 NMR structures of both peptide-RNA complexes of Rev and

228 Here we present NMR structures of CaBP1 in both Mg2+-bound and Ca2+-boun

229 Here we present NMR structures of CaBP4 in both Mg(2+)-bound and Ca(2+)-

230 rb beta-hairpin formation, as judged by (1)H NMR structures of four peptides determined to <1 A backb

231 tose binding to gal-1 and to derive solution NMR structures of gal-1 in the lactose-bound and unbound

232 High-resolution NMR structures of hIAPP bound to zinc reveal changes in

233 g-range interresidue distances obtained from NMR structures of holo to apo transitions in calmodulin.

234 Differing crystal and NMR structures of homologous proteins resulted in a cont

235 eing revealed by a combination of crystal or NMR structures of individual subunits and electron micro

236 Comparison to previous NMR structures of isolated, inactive substrates provides

237 E2 from Asticcacaulis excentricus, we solved NMR structures of its substrates astexin-2 and astexin-3

238 We determined the NMR structures of mouse and human Fas TM domains in bice

239 X-ray and NMR structures of protein-protein complexes, their assoc

240 e have developed an approach for determining NMR structures of proteins over 20 kDa that utilizes spa

241 By solving solution NMR structures of selected macrocycles and combining the

242 The solution NMR structures of the 20 kDa apo-YdbC dimer and YdbC:dT(

243 The 3D NMR structures of the analogues in dimethylsulfoxide are

244 Solution NMR structures of the blue light-absorbing dark state Pb

245 ted compounds enabled the elucidation of the NMR structures of the C-terminal domain of EB1 in the fr

246 different orientations in several X-ray and NMR structures of the CTD dimer and full-length CA prote

247 Recent crystal and NMR structures of the CXC chemokine receptors (CXCR) CXC

248 6-Glu22 of Abeta42) mutated forms of IDE and NMR structures of the full-length Abeta40 and Abeta42 ha

249 Solution NMR structures of the homologous Bacillus subtilis CopL,

250 We report the solution NMR structures of the hyperthermophilic Pyrococcus abyss

251 We solved separate NMR structures of the IQ motif (residues 1,646-1,664) bo

252 We determined NMR structures of the NCS-1 homolog from fission yeast (

253 NMR structures of the regulatory domain show that its ac

254 we report 1.4- and 1.5- angstrom solid-state NMR structures of the transmembrane domain of the closed

255 The x-ray crystal and solution NMR structures of the transmembrane region of the M2 hom

256 High-resolution NMR structures of these acylated forms revealed that act

257 gh resolution crystal structure and solution NMR structures of this motif reveal a novel and stable h

258 Here, we present the NMR structures of ToxB and its inactive homolog Ptr toxb

259 re the DNA cytidine deaminase activities and NMR structures of two A3G catalytic domain constructs.

260 Although multiple solution NMR structures of XPA(98-219) have been determined, the

261 NMR structures of zeta-subunits, which are recently disc

262 The nuclear magnetic resonance (NMR) structure of a central segment of the previously an

263 The nuclear magnetic resonance (NMR) structure of a globular domain of residues 1071 to

264 e, we report the nuclear magnetic resonance (NMR) structure of a stem-loop within the c-JUN 5' UTR re

265 report the first nuclear magnetic resonance (NMR) structure of a synthetic agnoprotein peptide spanni

266 ent the solution nuclear magnetic resonance (NMR) structure of mouse hepatitis virus (MHV) nsp3a and

267 re we report the nuclear magnetic resonance (NMR) structure of the membrane-embedded, heterotrimeric

268 The nuclear magnetic resonance (NMR) structure of Vav1 SH2 in complex with a doubly phos

269 The nuclear magnetic resonance (NMR) structures of the I544A and L529A I544A mutants in

270 The nuclear magnetic resonance (NMR) structures of the P22, CUS-3, and Sf6 I-domains rev

271 The WSK3 NMR structure (PDB ID code 2K1E) resembles the KcsA crys

272 SIM-SUMO interfaces in a previously reported NMR structure (PDB: 2mp2) of a complex formed by a SUMO3

273 stance and angle constraints, and a reliable NMR structure represented by a family of conformers.

274 helices of collagen fibers whereas solution NMR structures reveal the simpler interactions of isolat

275 The native NMR structure revealed a novel fold comprising a four st

276 The NMR structure revealed that this deletion mutant undergo

277 Our NMR structure reveals that both lobes of CaM collapse on

278 A solution NMR structure reveals that the native Pin WW beta-sheet

279 While prior X-ray crystal and NMR structures show that DNA with oxoG lesions appears v

280 The NMR structure shows that AGR2 consists of an unstructure

281 The NMR structure shows that the heptaloop adopts a well-org

282 A solution NMR structure shows that the homodimer exhibits parallel

283 The previously solved alpha(3)Y solution NMR structure shows that Y(32) is sequestered ~7.7 +/- 0

284 vel of agreement approaches the precision of NMR structures solved in different membrane mimetics.

285 NMR structures solved under molecular crowding experimen

286 re, we use comparative analysis of chemokine NMR structures, structural modeling, and molecular dynam

287 Thus, the NMR structure suggests a unified scheme for the initiati

288 NMR restraints yields more accurate protein NMR structures than those that have been deposited in th

289 ct of P6.1 pseudouridylation on its solution NMR structure, thermodynamic stability of folding and te

290 ted on its first ubiquitin-like domain whose NMR structure thus was determined.

291 We have found that refinement of protein NMR structures using Rosetta with experimental NMR restr

292 In addition, the NMR structure was determined for Ca(2+)-S100A1 bound to

293 Furthermore, its NMR structure was elucidated and employed in a molecular

294 rotocol for restrained refinement of protein NMR structures was also compared with restrained CS-Rose

295 3D NMR structures were calculated for des-AA(1,4-6,10,12,13

296 The NMR structures were determined to a backbone root mean s

297 ystal, all of the restrained Rosetta refined NMR structures were sufficiently accurate to be used for

298 dy, we combined information from crystal and NMR structures with mutagenesis and enzyme kinetics to i

299 not near RNA in the crystal structures or in NMR structures with RNA oligomers (aa 37-46).

300 e modeled on the nuclear magnetic resonance (NMR) structure without significant distortion.