ライフサイエンスコーパス: NRG1

1 NRG1 deletion reduces proliferation in intestinal crypts

2 NRG1 downregulation in PV neurons co-tracks both the fas

3 NRG1 enhanced excitatory drive onto fast spiking interne

4 NRG1 enhanced the strength of excitatory synapses onto F

5 NRG1 is the ligand for ERBB3 and 4, members of the epide

6 NRG1 robustly stimulates proliferation in crypts and ind

7 NRG1 treatment prevents the loss of deprived eye visual

8 NRG1 type I-IV and NRG1-IVNV isoforms were evaluated wit

9 NRG1 was localized to the wound epithelium prior to blas

10 NRG1, but not EGF, is upregulated upon damage and is exp

11 NRG1-IVNV was expressed from 16 weeks gestation until ag

12 NRG1/ErbB4 signaling in parvalbumin-expressing (PV) inhi

13 ESISTANCE 1 (ADR1) and N REQUIREMENT GENE 1 (NRG1), that act as "helper" NLRs during multiple sensor

14 ptibility 1 (EDS1) and N requirement gene 1 (NRG1), which encode regulators required for TIR immune f

15 Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are

16 We show that neuregulin 1 (NRG1) and hepatocyte growth factor (HGF) provide resista

17 Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are cr

18 Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 ar

19 We provide evidence that neuregulin 1 (NRG1) and its receptor ErbB4 tyrosine kinase are critica

20 scued by the administration of neuregulin 1 (NRG1) and nerve growth factor (NGF) recombinant proteins

21 Neuregulin 1 (NRG1) and the gamma-secretase subunit APH1B have been pr

22 Here, we identified neuregulin 1 (NRG1) as a key EGF family ligand that drives tissue repa

23 tudies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematog

24 Some studies suggest that neuregulin 1 (NRG1) could be involved in the regulation of skeletal mu

25 We identify neuregulin 1 (NRG1) in CAF supernatant, which promotes resistance in t

26 he only autonomous receptor of neuregulin 1 (NRG1) in the basolateral amygdala (BLA), was expressed i

27 Neuregulin 1 (NRG1) is a multifunctional neurotrophin that mediates ne

28 Neuregulin 1 (NRG1) is a secreted trophic factor that activates the po

29 Neuregulin 1 (NRG1) is an axon-derived factor that is critical for Sch

30 protective missense variant in neuregulin 1 (NRG1) linked to schizophrenia by meta-analysis (ie, rs10

31 val, we obtained evidence that neuregulin 1 (NRG1) produced by TICs promotes their proliferation and

32 lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive function and neu

33 Neuregulin 1 (NRG1) type III is involved in myelination of the periphe

34 ignals from the axonal protein neuregulin 1 (NRG1) type III regulate Schwann cell fate and myelinatio

35 Neuregulin 1 (NRG1), a critical developmental neurotrophin, is associa

36 that the signalling pathway of neuregulin 1 (NRG1), a protein involved in the regulation of skeletal

37 However, the source of neuregulin 1 (NRG1), the ligand for ErbB3, is unknown.

38 ase B receptor (BDNF/TrkB) and neuregulin 1 (NRG1)/ErbB2.

39 The Neuregulin 1 (NRG1)/ErbB4 signaling pathway has been genetically and f

40 studies implicate variants of Neuregulin-1 (NRG1) and its neuronal receptor ErbB4 in schizophrenia a

41 Neuregulin-1 (NRG1) and its receptor ErbB4 influence several processes

42 is related to the abundance of neuregulin-1 (NRG1) expressed on the axon surface.

43 ally induces downregulation of neuregulin-1 (NRG1) expression in parvalbumin-expressing (PV) inhibito

44 he neuronally secreted protein Neuregulin-1 (NRG1) fulfills all these criteria in the axolotl.

45 sed by disruption of BMP10 and Neuregulin-1 (NRG1) signaling pathways, two central mediators of myoca

46 Neuregulin-1 (NRG1) signaling through its tyrosine kinase receptor Erb

47 production of the ErbB3 ligand neuregulin-1 (NRG1).

48 ance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor) or CD44 (receptor-tyrosin

49 Neuregulin protein 1 (NRG1) is a large (> 60-amino-acid) natural peptide ligan

50 e critical period downregulates neuregulin-1(NRG1)/ErbB4 signaling in PV neurons, causing retraction

51 gulators, LIMK and SSH1, as end targets of a NRG1 signaling pathway and demonstrates that cofilin1 is

52 ormation, whereas knockdown of YAP abrogates NRG1- and HBEGF-stimulated cell proliferation.

53 ACE1 is a protease needed to generate active NRG1 from the full-length form.

54 ly, we show that interneuronal DISC1 affects NRG1-ErbB4-mediated phenotypes in the fast spiking inter

55 We demonstrate that the ADR1 and NRG1 families act in an unequally redundant manner in ba

56 erms carry two RPW8-NLR subclasses: ADR1 and NRG1.

57 tion and proliferation in HER2-amplified and NRG1-expressing cancer cells, and it displayed single-ag

58 In summary, Mycn acts downstream of BMP and NRG1 cardiogenic signaling pathways to promote normal my

59 ression of MYCN is regulated by both BMP and NRG1 signaling.

60 levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization

61 a functional relationship between DISC1 and NRG1-ErbB4 signalling in mature cortical interneurons.

62 hanism by which cross-talk between DISC1 and NRG1-ErbB4 signalling may contribute to these deficits.

63 hrenia (for example, COMT, DISC1, DTNBP1 and NRG1).

64 ession of GSTT2, CTSA, PPARG, CDA, ENPP1 and NRG1-Iis changing over time and correlates with disease

65 ter injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating re

66 NCOA4-RET and LMNA-NTRK1 fusions and NRG1 and GNAS amplifications were found in intrinsic-res

67 ral genes (ACSM3, ERI2, IL18RAP, IL23RAP and NRG1) with left ventricular hypertrophy phenotypes.

68 rbB4 is highly abundant in interneurons, and NRG1-mediated erbB4 activation has been shown to modulat

69 NRG1 type I-IV and NRG1-IVNV isoforms were evaluated with quantitative real

70 orrelation between ETV1 expression level and NRG1, ERBB4, SCN5A, and GJA5 levels in human LA samples.

71 Notch1 and NRG1 expression are associated in melanoma and inhibitio

72 autocrine signaling loop between Notch1 and NRG1 that controls melanoma growth and provide experimen

73 also demonstrate that the effects of RET and NRG1 are universal across European and Asian ancestries.

74 ue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes.

75 usceptibility variants at the RET, SEMA3 and NRG1 loci have been detected through genome-wide associa

76 susceptibility alleles at the RET, SEMA3 and NRG1 loci.

77 suggest that BRCA1-IRIS and/or BDNF/TrkB and NRG1/ErbB2 could serve as rational therapeutic targets f

78 ions between striatal gray matter volume and NRG1 genotype.

79 mmending novel applications of clinical anti-NRG1/HER3 therapeutics in treating CRPC.

80 s required for the induction of an antisense NRG1 transcript.

81 In Arabidopsis, NRG1 is required for the hypersensitive cell death respo

82 ncorporating complex ligand agonists such as NRG1 into an antibody scaffold.

83 Single-pass NRGs, such as NRG1 Types I/II and NRG2, accumulate as unprocessed prof

84 This SNP, located at NRG1, a susceptibility gene for schizophrenia, was prior

85 06030) and at SEMA3 (rs11766001), but not at NRG1.

86 transgenic mice that expressed excess axonal NRG1-III exhibited continued remodeling, in contrast to

87 Because NRG1 and ErbB4 are susceptibility genes of schizophrenia

88 entified biological and disease link between NRG1-ErbB4, p110delta, and AKT; and suggest that p110del

89 Both NRG1 and erbB4 have been repeatedly associated with schi

90 Both NRG1 and its receptor, ErbB4, are well-established risk

91 Considering that both NRG1 and ErbB4 are susceptibility genes of schizophrenia

92 ternative splicing, and association of brain NRG1 type IV isoform expression with the schizophrenia-r

93 growth factor neuregulin-1 (Nrg1, encoded by NRG1) is a key signalling factor controlling myelination

94 e found that the glutamatergic impairment by NRG1 overexpression required LIM domain kinase 1 (LIMK1)

95 , and LTP inhibition or reversal mediated by NRG1/ErbB signaling, which requires ErbB4 receptors in P

96 regulates Rac1 activation by BDNF but not by NRG1-Type III in Schwann cells, although both ligands ac

97 analysis confirms the recently reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathwa

98 nown about the function of NRG2, the closest NRG1 homolog.

99 Consistently, NRG1 treatment induces a proliferative gene signature an

100 deficits in ctoNrg1 mice require continuous NRG1 abnormality in adulthood, suggesting that relevant

101 In stark contrast, NRG1 had minor effects on whole-cell potassium currents.

102 Conversely, NRG1 cleavage, ErbB4 activity and GABA transmission are

103 le (T) of rs6994992 conferred lower cortical NRG1-IVNV levels.

104 Both NRG3 and CRD-NRG1 cluster on axons through juxtacrine interactions wi

105 We furthermore show that NRG3, like CRD-NRG1, is a dual-pass transmembrane protein that harbors

106 s unprocessed proforms, axonal puncta of CRD-NRG1 and NRG3 are comprised of processed protein.

107 Mutations of CRD-NRG1 and NRG3 that render them resistant to BACE cleavag

108 By contrast, dual-pass CRD-NRG1 and NRG3 are constitutively processed by BACE and a

109 In developing intestine enteroid cultures, NRG1, but not EGF, permitted increased cellular diversit

110 (MBP) in SC culture medium containing dBcAMP/NRG1, which induced differentiation.

111 mTORC1/2 inhibitor treatment decreased NRG1 expression and downregulated ERBB3 while re-activat

112 , we show that squamous tumors are dependent NRG1 signaling in vivo, in both genetically engineered m

113 ether, our results show that nerve-dependent NRG1/ErbB2 signaling promotes blastemal proliferation in

114 protective effects of fibroblast/CAF-derived NRG1 on cell growth properties of RAF inhibitor-treated

115 These data suggest mesenchymal-derived NRG1 is a potent mediator of tissue regeneration and may

116 y, after the switch to a well-balanced diet, NRG1 cleavage ratio and ErbB4 amount were increased.

117 ronal deficits and involvement of the DISC1, NRG1 and ErbB4 genes in schizophrenia, respectively.

118 mTORC1/2 inhibition downregulates NRG1-ERBB3, while upregulating pAkt T308 through an adap

119 Endogenous NRG1-ErbB4 signaling pathway in the BLA could modulate a

120 Neutralizing endogenous NRG1, inhibition, or genetic ablation of ErbB4, which wa

121 Exogenous NRG1 rapidly restores excitatory inputs onto deprived PV

122 These effects are blocked by exogenous NRG1 as well as PV targeted receptor knockout.

123 Moreover, exogenous NRG1 also produced an anxiolytic effect in the stressed

124 tioned-medium from NF2-null ACs or exogenous NRG1 stimulated ERBB3, EPHA2, and mTORC1/2 signaling, su

125 ore, overexpression of transcription factors NRG1 and UME6, to maintain yeast and hyphal morphologies

126 In angiosperm families, NRG1 co-occurs with TIR-NLR Resistance (R) genes.

127 Consistent with these findings, NRG1 effects on hippocampal long-term potentiation at CA

128 these results identify a novel mechanism for NRG1 cleavage and shedding.

129 four for ERBB4, three for DISC1 and one for NRG1.

130 ne kinase (RTK) since it is the receptor for NRG1 on the surface of Schwann cells.

131 targeting ERBB3 and cMET, the receptors for NRG1 and HGF, respectively, overcome resistance to trame

132 ulate interneuron function, but the role for NRG1-erbB4 signaling in regulating interneuron dendritic

133 gy, and pharmacology, we identify a role for NRG1-IV in learning, memory, and cognition and determine

134 These data demonstrate a novel role for NRG1-IV in learning, memory, and neural circuit formatio

135 results in the secretion of this domain from NRG1 type III.

136 nctional analysis revealed that three genes, NRG1, MST1 and NAT9, were strongly correlated with the p

137 nstrate that the modulation of axon-to-glial NRG1 type III signaling has beneficial effects and impro

138 ) and production of EGF-like ligands (HBEGF, NRG1 and NRG2).

139 -Men-1, particularly neuregulin-1/heregulin (NRG1), and confirm increased NRG1 secretion and activati

140 e and absence of the ERBB3 ligand heregulin (NRG1).

141 terneurons, and offer novel insight into how NRG1/ErbB4 signaling can impact hippocampal activity.

142 h occurs in schizophrenia, understanding how NRG1-erbB4 signaling modulates interneuron dendritic mor

143 T, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RELN, SNAP-25, TNIK), brain development, myelinati

144 enic mouse model engineered to express human NRG1-IV, an isoform of the NRG1 (Neuregulin 1) gene that

145 mouse model (NRG1-IV/NSE-tTA) in which human NRG1-IV is selectively overexpressed in a neuronal speci

146 Both type I and type III NRG1 improves deficits in the Morris water-maze behavior

147 uble ectodomains of both type I and type III NRG1 significantly increased expression of Abeta-degradi

148 possibility, full-length type I or type III NRG1 was overexpressed via lentiviral vectors in the hip

149 Neuregulin 1 type III (NRG1 type III) is a major physiological substrate of bet

150 ow that diet-induced obesity does not impair NRG1 signalling in rat skeletal muscle.

151 TP is an insuppressible form due to impaired NRG1/ErbB signaling, possibly through the loss of PV int

152 hway and that chronic exercise could improve NRG1 signalling in rat skeletal muscle.

153 ting reveals a novel association with FT4 in NRG1.

154 metalloprotease ADAM17, which is involved in NRG1 shedding.

155 isease, however, consistent with its role in NRG1 processing we find that BACE1 inhibition significan

156 by a schizophrenia candidate gene variant in NRG1.

157 in-1/heregulin (NRG1), and confirm increased NRG1 secretion and activation of V-ERB-B avian erythrobl

158 ctivation of ADAM17 in rat myoblasts induced NRG1 cleavage and ErbB4 activation.

159 ough ligand-blocking HER3 antibodies inhibit NRG1-driven tumor growth, they are ineffective against H

160 se model, we demonstrate that DISC1 inhibits NRG1-induced ErbB4 activation and signalling.

161 ut the neurobiology of a novel NRG1 isoform, NRG1-IV, which is increased in the brains of individuals

162 Novel splice variants of NRG1-IV (NRG1-IVNV), with predicted unique signaling capabilities

163 and fail to increase DA in response to local NRG1 infusion into the dorsal hippocampus, medial prefro

164 In human lymphoblasts, NRG1-mediated phosphatidyl-inositol,3,4,5 triphosphate [

165 iption of NRG1-IVNV, compared with the major NRG1 isoforms, across human prenatal and postnatal prefr

166 cluding ALK, BRAF, FGFR1, FGFR2, FGFR3, MET, NRG1, NTRK1, NTRK2, NTRK3, RET and ROS1 on eleven formal

167 Here, we developed a transgenic mouse model (NRG1-IV/NSE-tTA) in which human NRG1-IV is selectively o

168 Here we ask if modulating NRG1 type III levels in neurons would restore myelinatio

169 g from overexpression of HER2 or neuregulin (NRG1) in cancer leads to HER3-mediated oncogenic activat

170 Neuregulin1 (NRG1) is a single transmembrane protein that plays a cri

171 owth factor (EGF) family member NEUREGULIN1 (NRG1).

172 regulates the transcription of neuregulin1 (NRG1) by binding to its promoter region.

173 the levels of membrane-tethered neuregulin1 (NRG1-III), a potent activator of SCs normally presented

174 e is known about the neurobiology of a novel NRG1 isoform, NRG1-IV, which is increased in the brains

175 Our data reveal the direct actions of NRG1 signaling in ErbB4-expressing interneurons, and off

176 re NF2 loss leads to secretion/activation of NRG1-ERBB3 signaling.

177 f Glycogen synthase kinase 3, or addition of NRG1 significantly enhanced the efficiency of transdiffe

178 Addition of NRG1-beta to these cells restored their epithelial pheno

179 The administration of NRG1 into the BLA of high-anxiety mice alleviated their

180 le-phenotype analyses we find association of NRG1 with left ventricular hypertrophy phenotypes, fibri

181 t the NRG1 locus, involving a novel class of NRG1 proteins.

182 is a potent activator and key determinant of NRG1 ED cleavage and shedding.

183 ffectively reverses the protective effect of NRG1 and HGF in trametinib-treated cells.

184 These effects of NRG1 are primarily attributable to decreased voltage-gat

185 Expression of NRG1 types I, II, and III was temporally regulated durin

186 hway, which down-regulates the expression of NRG1, the major repressor of hyphal development.

187 veral studies have addressed the function of NRG1 in brain, very little is known about the cleavage a

188 ings identify a lineage-specific function of NRG1 in SCCs of diverse anatomic origin.

189 To understand the function of NRG1-ErbB2/3 signaling axis in adult Schwann cell biolog

190 ohistochemistry and in situ hybridization of NRG1 and its active receptor ErbB2 revealed that they ar

191 Supplementation by implantation of NRG1-soaked beads rescued regeneration to digits in dene

192 Conversely, increase of NRG1 in adulthood was sufficient to cause glutamatergic

193 T308, suggesting a mechanism independent of NRG1-ERBB3 but likely involving activation of another up

194 t models, and demonstrate that inhibition of NRG1 induces keratinization and terminal squamous differ

195 are associated in melanoma and inhibition of NRG1 signaling leads to melanoma cell growth inhibition

196 ted limbs, and pharmacological inhibition of NRG1 signaling reduced cell proliferation, blocked blast

197 indings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatme

198 g high levels of phospho-ErbB3, knockdown of NRG1 reduced cell viability and was associated with decr

199 hat ctoNrg1 mice, which mimic high levels of NRG1 observed in forebrain regions of schizophrenic pati

200 Given that levels of NRG1-III expression normally peak during the period of s

201 study provides the first quantitative map of NRG1 isoform expression during human neocortical develop

202 lecular, cellular, and circuit mechanisms of NRG1/ErbB4 in regulating the initiation of critical peri

203 Because of the hairpin nature of NRG1 type III, two membrane-bound stubs with a type 1 an

204 elination defects by early overexpression of NRG1 type III.

205 rophysiological and behavioral phenotypes of NRG1 mutant mice have been investigated extensively, pra

206 re we investigated proteolytic processing of NRG1 type III and demonstrate that the ectodomain can be

207 r distribution and proteolytic processing of NRG1-IVNV isoforms were also determined.

208 dependent transcriptional down-regulation of NRG1 and Sok1-mediated degradation of Nrg1 protein.

209 mechanistic perspective on the relevance of NRG1 processing in schizophrenia.

210 d cleavage is required to allow signaling of NRG1 type III.

211 Moreover, stimulation of NRG1 cleavage by calcyon was recapitulated in HEK 293 ce

212 he type 2-oriented membrane-retained stub of NRG1 type III is further processed by signal peptide pep

213 severing protein, as a downstream target of NRG1 signaling in rat Schwann cells (SCs).

214 ed the temporal dynamics of transcription of NRG1-IVNV, compared with the major NRG1 isoforms, across

215 Novel splice variants of NRG1-IV (NRG1-IVNV), with predicted unique signaling cap

216 e that the stimulatory effects of calcyon on NRG1 cleavage and shedding depend on clathrin-mediated e

217 Neuregulin 1 (or NRG1, hereafter referred to as heregulin) increased CXCR

218 HBEGF or NRG1, in turn, activates YAP and stimulates cancer cell

219 (which encode proteins in the WNT pathway), NRG1 (which encodes an ERBB ligand), and IL16 (which enc

220 At the end of this period, NRG1 and ErbB expression/activity in skeletal muscle was

221 tor required for cellular migration, and pro-NRG1 (ADAM17 substrate), which releases the epidermal gr

222 ErbB4 following proteolytic cleavage of pro-NRG1 precursor protein.

223 itioned medium from fibroblasts that produce NRG1 and HGF.

224 taining the levels of ErbB2 and in producing NRG1 in axons.

225 Chronic exercise training also promoted NRG1 cleavage, resulting in increased ErbB4 phosphorylat

226 On the other end, addition of recombinant NRG1 can partially restore melanoma cell growth that is

227 promoters of hypha-specific genes or reduced NRG1 expression.

228 we demonstrate that TP63 directly regulates NRG1 expression in human SCC cell lines and that NRG1 is

229 and whether exercise and diet might restore NRG1 signalling in skeletal muscle of obese rats.

230 fit from therapeutic intervention to restore NRG1 signaling.

231 is not only controlled by membrane-retained NRG1 type III, but also in a paracrine manner via proteo

232 In isolated SCs, NRG1 promotes dephosphorylation of cofilin1 and its upst

233 xis by cancer-associated fibroblast-secreted NRG1 mediates castration resistance, recommending novel

234 se depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cde

235 ryos, which can then be rescued with soluble NRG1.

236 Some NRG1-dependent R proteins also signal partially via the

237 inhibition via downregulation of PV-specific NRG1 signaling.

238 Overexpression of calcyon stimulates NRG1 cleavage and signaling in vivo, and as a result, GA

239 ination, our findings identify axon-tethered NRG1 as a molecular determinant for SC-driven neuromuscu

240 expression in human SCC cell lines and that NRG1 is a critical component of the TP63 transcriptional

241 In this study, we demonstrate that NRG1 is highly expressed by dermal fibroblasts and cance

242 and behavioral analyses, we demonstrate that NRG1-IV/NSE-tTA mice exhibit abnormal behaviors relevant

243 We found that NRG1 acutely attenuates ErbB4-expressing interneuron exc

244 a tissue microarray analysis, we found that NRG1 expression and associated HER2 activation occurred

245 These findings support the idea that NRG1, acting in a paracrine manner, promotes resistance

246 These observations indicated that NRG1 signaling maintains high GABAergic activity in amyg

247 Together, these observations indicated that NRG1-ErbB4 signaling is critical to maintaining GABAergi

248 cortical pyramidal neurons, indicating that NRG1 effects on principal neurons are indirect.

249 We discovered recently that NRG1/ErbB4 signaling in PV neurons is critical for the i

250 We show that NRG1 isotypes I and II, which like NRG2 are single-pass

251 Here we show that NRG1/erbB4 promote the growth of dendrites in mature int

252 Assays showed that NRG1-IVNV is a novel nuclear-enriched, truncated NRG1 pr

253 Our study shows that NRG1 is probably a susceptibility gene for CaD, based on

254 These results suggest that NRG1 provides beneficial effects in candidate neuropatho

255 Recent studies suggest that NRG1 signaling plays a role in remyelination of regenera

256 Our data suggest that NRG1 type III-dependent myelination is not only controll

257 reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathway fusions may play important r

258 ession in the visual cortex and support that NRG1/ErbB4 signaling is implicated in both critical peri

259 The NRG1 ecto-domain (ED) binds and activates ErbB4 followin

260 The NRG1 gene undergoes extensive alternative splicing and,

261 The NRG1 gene undergoes extensive alternative splicing, and

262 aining and a well-balanced diet activate the NRG1 signalling in skeletal muscle of obese rats, possib

263 training and well-balanced diet activate the NRG1-ErbB4 pathway, possibly via the metalloprotease ADA

264 besity, but did not significantly affect the NRG1/ErbB signalling pathway in rat skeletal muscle.

265 developmental risk for schizophrenia at the NRG1 locus, involving a novel class of NRG1 proteins.

266 orrected P values >.05), and affected by the NRG1 genotype (higher striatal responses in controls wit

267 ost robust associations were observed in the NRG1 gene (rs6996585, P=1.08 x 10(-10)) and this SNP was

268 to express human NRG1-IV, an isoform of the NRG1 (Neuregulin 1) gene that is increased in the brains

269 ith its role as an important mediator of the NRG1 (Neuregulin 1) signaling pathway and activator of r

270 d by increases in cortical expression of the NRG1 receptor, ErbB4 and the downstream signaling target

271 ced obesity could lead to alterations of the NRG1 signalling pathway and that chronic exercise could

272 d diet is associated with alterations of the NRG1 signalling pathway and whether exercise and diet mi

273 ld be partly explained by stimulation of the NRG1 signalling pathway.

274 sion of BRG1 influences the stability of the NRG1 transcript, thus controlling filamentation through

275 The mutation reduces generation of the NRG1 type III beta-peptide as well as reverses signaling

276 e conversely pharmacological blockade of the NRG1-ErbB pathway prevents myelination, providing direct

277 Pharmacological blockade of the NRG1/HER3 axis using clinical-grade blocking antibodies

278 tify a genetic pathway that converges on the NRG1-responsive transcription factor ETV1 as a critical

279 studies support the rationale to target the NRG1-ErbB3-ErbB2 axis as a novel treatment strategy in a

280 ent R proteins also signal partially via the NRG1 sister clade, ADR1.

281 Thus, NRG1 is required for full TIR-NLR function and contribut

282 Thus, NRG1 type III is the first protein substrate that is not

283 adhesion kinase, and paxillin in response to NRG1, but fail to increase in size possibly due to stabi

284 genesis in rat Schwann cells, in response to NRG1, TGFbeta, and laminins, three major signals implica

285 y, trametinib enhances the responsiveness to NRG1 and sustained HGF-mediated activation of AKT.

286 -IVNV is a novel nuclear-enriched, truncated NRG1 protein resistant to proteolytic processing.

287 sistant prostate cancer with increased tumor NRG1 activity have an inferior response to second-genera

288 ve inhibitory neurons infected using the TVB-NRG1 bridge protein receives inputs indiscriminately fro

289 in glioblastoma, MSN-ROS1, TRIM4-BRAF, VAMP2-NRG1, TPM3-NTRK1 and RUFY2-RET in lung cancer, FGFR2-CRE

290 uminal cell signaling, controlled by p63 via NRG1, orchestrates the entire lactation program.

291 We propose that some NLRs signal via NRG1 only, some via ADR1 only and some via both or neith

292 After another 8 weeks, NRG1 and ErbB expression/activity in skeletal muscle wer

293 guingly, these deficits were diminished when NRG1 expression returned to normal in adult mice, sugges

294 We tested whether NRG1 is required for signalling of multiple TIR-NLRs.

295 (-10)) and this SNP was also associated with NRG1 expression in thyroid tissues.

296 The association of rs6994992 genotype with NRG1-IVNV expression and the subcellular distribution an

297 In addition, cells were incubated with NRG1-beta, a mediator of HER2-HER3 signaling, or A83-01,

298 fact, synaptic SCs of these adult mice with NRG1-III overexpression exhibited behaviors evident in w

299 the adult rodent brain does not overlap with NRG1 and is more extensive than originally reported, inc

300 y examined the association of rs6994992 with NRG1-IVNV expression.