ライフサイエンスコーパス: NTM

1 NTM and CNTNAP4 were shown to be expressed in ocular tis

2 NTM disease was defined by 1) American Thoracic Society/

3 NTM grew from 6 unused saline flushes compounded by clin

4 NTM grew from 6 unused saline flushes compounded by Clin

5 NTM infection is of increasing prevalence in the UK pedi

6 NTM infection was not associated with increased mortalit

7 NTM infection was not associated with increased mortalit

8 NTM keratitis should be considered in the differential d

9 NTM otomastoiditis should be suspected if a patient has

10 NTM prevalence varies significantly among patients with

11 NTM species were unidentifiable in 29.2% [2,623 of 8,980

12 NTM were identified by matrix-assisted laser desorption

13 NTM were investigated in the water-main biofilms and dri

14 NTM were recovered from 17 of 224 sputum samples using R

15 NTM-DR sensitivity and specificity in the detection of c

16 NTM-infected patients had at least 1 positive culture fo

17 NTM-w cells also exhibited decreased levels of active Rh

18 NTMs were detected in 78% of the water samples.

19 nsisted of 3 treatments supplemented with 0 (NTM), low (LTM) and high (HTM) TM levels in the same bas

20 Sera from 12 NTM-PD patients due to Mycobacterium avium, M. intracell

21 A total of 133 NTM isolates were recovered overall from 101 (49.8%) spe

22 ica criteria for respiratory specimens or 2) NTM cultured from a sterile site with a compatible clini

23 Normal (n = 3 NTM) and glaucomatous (n = 3 GTM) human TM cell lines we

24 We report 3 NTM infections in otherwise healthy persons who received

25 From June 2009 to March 2012, 36 NTM isolates recovered from 10 (7.75%) out of 129 childr

26 A retrospective study of 853 NTM isolates from respiratory samples from 386 patients

27 The prevalence of individuals with a NTM-positive respiratory culture increased every year fr

28 In addition, NTM and GTM tissue samples were examined by immunohistoc

29 potency of tedizolid than linezolid against NTM and suggest that an evaluation of tedizolid as a pot

30 ssociated with increased mortality, although NTM disease was associated with increased mortality comp

31 Detection of an NTM helps ensure that the negative result for M. tubercu

32 Human TM cell lines NTM-5 and NTM-5 transfected to overexpress Bves (NTM-w) were evalu

33 rst time that an association between FLA and NTM is observed in water networks, highlighting the impo

34 Thus, both MTB and NTM appear to elicit a phenotypically similar T-cell res

35 e reveal homodimeric structures of NEGR1 and NTM.

36 2, SUR2A, and SUR2B were expressed in TM and NTM cells.

37 to naturally processed epitopes from MTB and NTMs, whereas T cells reactive to MTB-specific epitopes

38 tients with NTM, 66 (30%) were classified as NTM pulmonary disease suspects, 9 (4%) with NTM pulmonar

39 nvestigated whether miRNAs have potential as NTM-PD biomarkers.

40 TGM2 enzyme activity between NTM and GTM cells was studied by using a biotin cadaveri

41 Both NTM and GTM cultured cells expressed prepro-ET-1 mRNA le

42 the expression of the ET(A) receptor in both NTM and GTM cells, and this was supported by the absence

43 strated the presence of TGM2 protein in both NTM and GTM cells.

44 This study demonstrated that both NTM and GTM cells express TGM2.

45 The immune response to both NTM and Mycobacterium tuberculosis is based on cellular

46 5 and NTM-5 transfected to overexpress Bves (NTM-w) were evaluated for TJ formation, and levels of oc

47 nd antibiotic resistance patterns of certain NTM isolates highlight the importance of correct diagnos

48 In children, NTM cause lymphadenitis, skin and soft tissue infections

49 y virus infection) caused by the most common NTM pathogens such as Mycobacterium avium complex, Mycob

50 Thirty-one cases of suspected or confirmed NTM inoculation from professional tattooing were uncover

51 haracterized 3 of 3 specimens that contained NTM.

52 tients re-admitted to hospital, and deaths), NTM concentrations were significantly different between

53 tive RhoA and lower levels of MLC-p than did NTM-5 cells.

54 no specific lesions that could differentiate NTM infection from MDR-TB; however, the most common lesi

55 tuberculous mycobacterial pulmonary disease (NTM-PD).

56 lassify patients into NTM pulmonary disease, NTM pulmonary disease suspects, NTM disseminated disease

57 nosed, our results suggest that disseminated NTM disease may cause false-positive LF-LAM results.

58 We evaluated the GenoType NTM-DR (NTM-DR) line probe assay for identifying Mycobacterium a

59 Healthcare facilities with endemic NTM should consider similar tap water avoidance and engi

60 this outbreak include adding extrapulmonary NTM to ADH's reportable disease list and providing more

61 Finally, NTM-specific epitopes that elicit T cells that recognize

62 fied four miRNAs as potential biomarkers for NTM-PD and provided insight into NTM-PD pathophysiology.

63 easing globally, but specific biomarkers for NTM-PD have not been established.

64 years with at least one positive culture for NTM in 2011.

65 patients had at least 1 positive culture for NTM posttransplant.

66 cts with three or more positive cultures for NTM had two or more characteristic findings on entry HRC

67 r NTM, few meet a strict case definition for NTM disease.

68 n total, 272 water samples were examined for NTM using a membrane filtration, culture method.

69 frequently have sputum cultures positive for NTM, few meet a strict case definition for NTM disease.

70 ycobacterial cultures; 14% were positive for NTM.

71 s supported the discriminative potential for NTM-PD and their combination provided an improved diagno

72 saturated vapor pressure increased risk for NTM (odds ratio = 1.06; 95% confidence interval = 1.02-1

73 macrolide resistance, routine screening for NTM should be considered for persons with CF.

74 tive treatment and prevention strategies for NTM infection in young people with CF.

75 undertook detailed environmental testing for NTM and defined potential opportunities for transmission

76 ecipients; 18 of 43 (41.8%) were treated for NTM and 6 (13.9%) met disease criteria.

77 reported, whereas the opposite was true for NTM conserved epitopes, suggesting that intragenus conse

78 on provided an improved diagnostic value for NTM-PD.

79 f the taps that were repeatedly positive for NTMs, the species M. avium, M. mucogenicum, and Mycobact

80 have been isolated in pulmonary samples from NTM-infected patients in the region.

81 cted and differentiated M. tuberculosis from NTM.

82 Functionally, NTM-w cells showed decreased permeability and increased

83 Agreement of GenoType NTM-DR results with sequencing and phenotypic resistance

84 We evaluated the GenoType NTM-DR (NTM-DR) line probe assay for identifying Mycobac

85 Earlier reviews of global NTM epidemiology only included subject-level data from o

86 nables routine screening for rapidly growing NTM in all submitted sputum samples from patients with C

87 method for the isolation of rapidly growing NTM in this setting.

88 acterium abscessus among the rapidly growing NTM.

89 bacteria (NTM), and 42/48 (85%) slow growing NTM tested were identified correctly.

90 ycobacterium xenopi among the slowly growing NTM and Mycobacterium abscessus among the rapidly growin

91 One hundred forty-two slowly growing NTM, including 7/7 M. marinum, 7/7 M. kansasii, and 7/11

92 It detected slow-growing NTMs but without cross-reacting to common oral bacteria.

93 inic A during 22 March-12 September 2018 had NTM BSIs.

94 nic A during March 22-September 12, 2018 had NTM BSIs.

95 124 (12%) had tuberculosis and 218 (21%) had NTM.

96 Of 3338 SOT recipients, 50 (1.5%) had NTM infection during a median 1038 days (range, 165-3706

97 had drug-sensitive TB, and 380 (70.63%) had NTM infection.

98 iving antiretroviral therapy (ART), none had NTM disease compared with 19 (2%) of 1,009 not receiving

99 ART was associated with lower odds of having NTM disease.

100 However, NTM culture practices vary greatly, with some high-preva

101 creasing attention in recent years; however, NTM otomastoiditis is extremely rare.

102 in TH1/TH17 differentiation is attenuated in NTM-infected children.

103 iggering additional proteolytic cleavages in NTM, which allow its intracellular region to translocate

104 ed significantly higher serum expressions in NTM-PD patients than in controls.

105 ion of Bves led to increased TJ formation in NTM-5 cells.

106 protein levels were significantly higher in NTM tissues compared to GTM tissues.

107 s was used to compare TGM2 protein levels in NTM and GTM cells.

108 however, the most common lesion location in NTM infection was the medial aspect of the left lung.

109 mportant tools to dissect the role of MMP in NTM physiology and resilience.

110 ose polysaccharides (MMP) identified only in NTM.

111 There were no specific lesions present in NTM infection (p < 0.05) because almost all had a meanin

112 We found a decreasing trend in NTM keratitis while Microsporidia keratitis was consider

113 es were the least likely to develop incident NTM in 2011 (P < 0.01).

114 formed a nested case-control study: incident NTM cases were persons aged more than 5 years with at le

115 Patients with incident NTM infections from either MAC or M. abscessus were less

116 of Non-tuberculous mycobacterial infections (NTM) were sub-cultured and characterized.

117 markers for NTM-PD and provided insight into NTM-PD pathophysiology.

118 America guidelines to classify patients into NTM pulmonary disease, NTM pulmonary disease suspects, N

119 k 7H11 agar), for their abilities to isolate NTM.

120 Human TM cell lines NTM-5 and NTM-5 transfected to overexpress Bves (NTM-w)

121 ulation are hampered by inadequate mandatory NTM reporting and the overlap of clinical presentation w

122 nd primary normal human trabecular meshwork (NTM) cells were studied by Western blot and immunohistoc

123 ultures of normal human trabecular meshwork (NTM) cells.

124 mechanism to identify non-transition-metal (NTM) elements from a total set of 18 candidates that can

125 orm functional in vitro neural tissue mimic (NTM) of different shapes using stem cells, a fibrin matr

126 al transport and neoclassical tearing modes (NTMs) during transient nonlocal heat transport events in

127 f POAG, SNPs in two cell adhesion molecules, NTM and CNTNAP4, were identified and may increase POAG s

128 The Anyplex MTB/NTM assay demonstrates sensitivities, specificities, and

129 First, the T cells elicited by MTB/NTM cross-reactive epitopes in HCs were found mainly in

130 Second, T cells reactive to MTB/NTM-conserved epitopes responded to naturally processed

131 Multiple NTM species were identified in clinical and environmenta

132 n of nontuberculous (atypical) mycobacteria (NTM) during the tattooing process.

133 ntification of nontuberculosis mycobacteria (NTM) in patients presumably suffering from tuberculosis

134 rculosis (TB), nontuberculosis mycobacteria (NTM), and Mycobacterium tuberculosis drug resistance are

135 entification of nontuberculous mycobacteria (NTM) and their environmental isolates in about 3 h witho

136 Nontuberculous mycobacteria (NTM) are an important cause of pulmonary disease in pati

137 Nontuberculous mycobacteria (NTM) are frequently found in chloraminated drinking wate

138 Nontuberculous Mycobacteria (NTM) are opportunistic pathogens that share the same eco

139 Nontuberculous mycobacteria (NTM) are potential respiratory pathogens in cystic fibro

140 Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and an important

141 Although nontuberculous mycobacteria (NTM) are widely documented as a cause of illness among H

142 Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and caus

143 some species of nontuberculous mycobacteria (NTM) compared with that of linezolid.

144 Studies of nontuberculous mycobacteria (NTM) described a rapid rise in the prevalence and spatia

145 5, and 1.00 for nontuberculous mycobacteria (NTM) detection, respectively, making it a suitable scree

146 ce of the human nontuberculous mycobacteria (NTM) disease is rapidly increasing.

147 nt regimens for nontuberculous mycobacteria (NTM) disease.

148 he isolation of nontuberculous mycobacteria (NTM) from patients with CF.

149 Isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (C

150 Worldwide, nontuberculous mycobacteria (NTM) have become emergent pathogens of pulmonary infecti

151 Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide

152 Nontuberculous mycobacteria (NTM) infection has attracted increasing attention in rec

153 ase (PD) due to nontuberculous mycobacteria (NTM) is increasing globally, but specific biomarkers for

154 Infection with nontuberculous mycobacteria (NTM) is of growing clinical concern in people with cysti

155 berculosis from nontuberculous mycobacteria (NTM) is of primary importance for infection control and

156 C) is a form of Nontuberculous mycobacteria (NTM) of special, international concern in Cystic Fibrosi

157 Nontuberculous mycobacteria (NTM) represent over 190 species and subspecies, some of

158 e prevalence of nontuberculous mycobacteria (NTM) showed a decreasing trend (P = .0032), whereas Micr

159 C) strains from nontuberculous Mycobacteria (NTM) strains by targeting the IS6110 insertion element.

160 e rapid growing nontuberculous mycobacteria (NTM), and 42/48 (85%) slow growing NTM tested were ident

161 egionella spp., nontuberculous mycobacteria (NTM), and Mycobacterium avium complex (MAC), however, we

162 via aerosolized nontuberculous mycobacteria (NTM), it is important to characterize their persistence

163 pecies known as nontuberculous mycobacteria (NTM), some of which-namely Mycobacterium avium-are impor

164 mplex (MTC) and nontuberculous mycobacteria (NTM), using surface-enhanced Raman spectroscopy (SERS).

165 re and emerging nontuberculous mycobacteria (NTM).

166 nd slow-growing nontuberculous mycobacteria (NTM).

167 solation of all nontuberculous mycobacteria (NTM).

168 n presumptive non-tuberculosis mycobacteria (NTM) and the results were initially compared with the re

169 resentative of non-tuberculous mycobacteria (NTM) and other opportunistic human pathogens are enriche

170 Non-tuberculous mycobacteria (NTM) are a large family of acid-fast bacteria, widesprea

171 s (MDR-TB) and non-tuberculous mycobacteria (NTM) infection, which can be used in early diagnostic sc

172 f isolation of non-tuberculous mycobacteria (NTM) species from respiratory specimens is increasing, h

173 rly exposed to non-tuberculous mycobacteria (NTM) that live in soil and water reservoirs and vary in

174 Nontuberculous mycobacteria (NTMs) are environmental microorganisms that can cause in

175 conservation in nontuberculous mycobacteria (NTMs), suggesting environmental exposure as an underlyin

176 h disseminated nontuberculous mycobacterial (NTM) disease.

177 with suspected nontuberculous mycobacterial (NTM) infection after receiving tattoos at a local tattoo

178 t high risk of nontuberculous mycobacterial (NTM) infection, with treatment requiring prolonged multi

179 Nontuberculous mycobacterial (NTM) infections have the potential to affect outcomes in

180 reater risk of nontuberculous mycobacterial (NTM) infections than the general population.

181 68 MTBC and 97 nontuberculous mycobacterial (NTM) isolates grown on agar and 107 cultures grown in Ba

182 Pulmonary non-tuberculous mycobacterial (NTM) disease epidemiology in sub-Saharan Africa is not a

183 apidly growing nontuberculous Mycobacterium (NTM) species; on 5 September 2018, 6 additional BSIs wer

184 pidly growing, nontuberculous Mycobacterium (NTM) species; on September 5, 2018, six additional BSIs

185 a slow-growing nontuberculous mycobacterium (NTM), subsequent to cardiothoracic surgery.

186 onchromogenic, nontuberculous mycobacterium (NTM).

187 rug-resistant non-tuberculous mycobacterium (NTM) Mycobacterium abscessus, which causes progressive l

188 growth regulator 1 (NEGR1) and neurotrimin (NTM) are abundant cell-surface proteins found in the bra

189 S showed that the expression of neurotrimin (NTM) was highly upregulated, by 26.5 times (p<0.0001), i

190 dentified, rs7481514 within the neurotrimin (NTM) gene, that was significantly associated with POAG i

191 eferred to as Hain version 2 [V2]) and Nipro NTM+MDRTB detection kit 2 (referred to as Nipro), to Hai

192 e suspects, NTM disseminated disease, and no NTM categories.

193 sis was used to determine the association of NTM with mortality among lung transplant recipients.

194 on, and attempts to understand the burden of NTM disease and to identify risk factors in the paediatr

195 Characterization of NTM was performed by the Centers for Disease Control and

196 in the prevalence and spatial clustering of NTM in the United States over the past decade.

197 ignificant (P < 0.002) spatial clustering of NTM was detected, centering in Wisconsin, Arizona, Flori

198 tion phase showed that the concentrations of NTM in plasma were significantly higher in the responder

199 y and 99.9% specificity for determination of NTM identity.

200 not provide specific advice for diagnosis of NTM in children, from whom the quantity and quality of d

201 onditions relevant to the natural ecology of NTM, such as hypoxia, is lacking.

202 ting the importance of FLA in the ecology of NTM.

203 vaccines for TB, understanding the effect of NTM on vaccine efficacy may be a critical determinant of

204 goal was to investigate the epidemiology of NTM infection in the pediatric age group using data from

205 The epidemiology of NTM varies by world region, and attempts to understand t

206 the epidemiological and clinical features of NTM infection in children, with a specific focus on the

207 try (MALDI-TOF MS) for the identification of NTM isolated on RGM medium was also assessed.

208 Identification of NTM isolates was accomplished by polymerase chain reacti

209 Molecular identification of NTM was performed by using PCR restriction analysis targ

210 n of continuous and routine investigation of NTM infection or colonization in CF patients, including

211 selective brand of BCSA for the isolation of NTM from 224 sputum samples from patients with CF.

212 d highly effective tool for the isolation of NTM from patients with CF.

213 ivalent to that of the MGIT for isolation of NTM from the sputum of patients with CF.

214 d statistically significant higher levels of NTM in chloraminated water than in chlorinated water.

215 ntrolled trials to improve our management of NTM disease.

216 red amoebal cultures carried high numbers of NTM.

217 ic data were also obtained and predictors of NTM infection analyzed using regression analysis.

218 We investigated here the presence of NTM and FLA on a drinking water network during an all ye

219 This work investigated the presence of NTM in sputum samples of 129 CF patients (2 to 18 years

220 was collected to investigate the presence of NTM.

221 were obtained to estimate the prevalence of NTM among patients with CF 12 years of age or older by s

222 world, studies describing the prevalence of NTM disease among HIV-infected people in most resource-l

223 The prevalence of NTM disease was 2% (19 of 1,060).

224 The prevalence of NTM-associated diseases is increasing in the United Stat

225 The sensitivity of RGM30 for the recovery of NTM was significantly higher than that of either the MGI

226 cles on prevalence and clinical relevance of NTM detection in pulmonary samples in sub-Saharan Africa

227 d engineering strategies to decrease risk of NTM infection.

228 iled to detect any potential point source of NTM infection.

229 Still, given that environmental sources of NTM are ubiquitous and PNTM disease is rare, both host s

230 Further studies of NTM in HIV-infected individuals in tuberculosis-endemic

231 Four studies of therapy of NTM disease highlighted the pressing need for well-desig

232 antimicrobials proposed for the treatment of NTM but not yet addressed by the CLSI and molecular (gen

233 Treatment of NTM infections is very different from the treatment of t

234 nce-based recommendations about treatment of NTM pulmonary disease are provided.

235 and identifies and determines the species of NTMs.

236 the progress and bottlenecks in research on NTM epidemiology, immunology and heterologous immunity t

237 Among SOT patients, NTM were most frequently identified from lung transplant

238 Patients with CF and multiple positive NTM cultures, characteristic HRCT findings, and progress

239 In conclusion, pulmonary NTM disease is a neglected and emerging public health di

240 Although risk factors for pulmonary NTM such as advanced age and low BMI are known, the mech

241 % (266 of 952) of participants had pulmonary NTM disease and M. kansasii with a prevalence of 69.2% [

242 The prevalence of pulmonary NTM colonization was 7.5% (95% CI: 7.2%-7.8%), and 75.0%

243 4.7%] was the most common cause of pulmonary NTM disease.

244 epitopes that elicit T cells that recognize NTMs but not MTB were identified.

245 on of INH resistance and clinically relevant NTM are priorities.

246 The remaining NTM infected patients were classified as colonized.

247 Regarding amikacin resistance, NTM-DR detected rrs mutations in five isolates and yield

248 Regarding clarithromycin resistance, NTM-DR detected rrl mutations in 52 isolates and yielded

249 ith chronic Pseudomonas, macrolide-resistant NTM infections are of growing concern.

250 frequent transmission of multidrug resistant NTM between patients with cystic fibrosis despite conven

251 ment agent for infections caused by selected NTM is warranted.

252 (NEC) and a transmembrane signaling subunit (NTM).

253 ary disease, NTM pulmonary disease suspects, NTM disseminated disease, and no NTM categories.

254 Although TB-NTM coinfection may have been underdiagnosed, our result

255 Our findings suggest that NTM as a novel biomarker in heart failure will not only

256 The NTM species detected most frequently were: Mycobacterium

257 The NTM, in return, regulates the nonlocal transport by trun

258 The NTM-DR yielded accurate erm(41) genotype results for all

259 In contrast to the MTB complex cases, the NTM cases were more likely to have been diagnosed during

260 d as Mycobacterium tuberculosis complex, the NTM cross-reacts with the M. tuberculosis complex nuclei

261 rational surface and hence the onset of the NTM in relatively low beta plasmas (betaN < 1).

262 of graywash tattoo ink as the sources of the NTM infections.

263 all MTBC isolates and 97.9% and 95.8% of the NTM isolates from characterized agar cultures and MGIT b

264 provides a suggestion of the identity of the NTM present, when the most commonly encountered mycobact

265 The performance of the NTM-DR assay in rapid identification was evaluated by co

266 Our results indicate that the NTM-DR assay is a straightforward and accurate approach

267 A normal primary human TM (NTM) cell line and a TM cell line derived from a glaucom

268 d FST and Act A protein levels in normal TM (NTM) and glaucomatous TM (GTM) cells.

269 Compared to NTM, LTM reduced area under the curve (AUC) of FPD lesio

270 r patients with clinical pulmonary TB due to NTM and co-infection with HIV and the likely role of the

271 key clinical factors and health outcomes to NTM status was performed.

272 The lesion location related to NTM infection was the medial aspect of the left lung (p

273 ontribute to the increased susceptibility to NTM infection and its progression to pulmonary disease.

274 Exposure to NTMs occurs primarily through human interactions with wa

275 be used to characterize T-cell responses to NTMs, eliminating the confounding factor of MTB cross-re

276 Latanoprost-free acid (LFA)-treated NTM cells were analyzed for OPN gene and protein express

277 t all patients within each center had unique NTM strains.

278 for conclusive identification of the unknown NTM isolates.

279 Cambodia, where solid media alone was used, NTM was rare.

280 Of these, 191 (4%) were NTM-positive in 2011 only (cases); 5,212 (96%) were NTM-

281 itive in 2011 only (cases); 5,212 (96%) were NTM-negative in 2010 and 2011 (control subjects).

282 cated in obesity and mental disorders, while NTM is linked to intelligence and cognitive function.

283 NTM pulmonary disease suspects, 9 (4%) with NTM pulmonary disease, and 10 (5%) with NTM disseminated

284 with NTM pulmonary disease, and 10 (5%) with NTM disseminated disease.

285 Forty-three patients (86%) with NTM infection were lung transplant recipients; 18 of 43

286 P = .004) were significantly associated with NTM infection.

287 dition, a comprehensive review of cases with NTM otomastoiditis in the literature was also performed.

288 ood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from

289 e in TGM2 protein in GTM cells compared with NTM cells, and GTM cells also had increased in TGM2 enzy

290 reased in TGM2 enzyme activity compared with NTM cells.

291 permeability and increased TER compared with NTM-5 cells, consistent with increased TJ formation.

292 vis) and 69 (15%) were due to infection with NTM.

293 and cytokine responses between patients with NTM lung disease and demographically matched controls.

294 his study, we aimed to analyze patients with NTM otomastoiditis and establish a more efficient treatm

295 ds and temporal bone images of patients with NTM otomastoiditis were retrospectively analyzed.

296 are professionals who care for patients with NTM pulmonary disease, including specialists in infectio

297 Of 218 patients with NTM, 66 (30%) were classified as NTM pulmonary disease s

298 iption-PCR in an additional 40 patients with NTM-PD and 40 healthy controls confirmed that four diffe

299 Three of 6 lung transplant recipients with NTM disease died compared with 6 of 37 colonized (hazard

300 Among those with NTM infection, cases 35 years or younger were more likel