ライフサイエンスコーパス: Nocardia

1 equent colonization of a pathogenic bacteria Nocardia.

2 lity patterns vary with different species of Nocardia.

3 usters conserved in >90 different strains of Nocardia.

4 Acetobacter, Allobaculum, Ruminococcus, and Nocardia.

5 s; Burkholderia, 1.06 per 100 patient-years; Nocardia, 0.81 per 100 patient-years; Serratia, 0.98 per

6 ess of PCR amplification of a portion of the Nocardia 16S rRNA gene and subsequent restriction endonu

7 tion of N. veterana from the related species Nocardia africana and N. nova because of the very high d

8 r the identification of clinical isolates of Nocardia and for the detection of new or unusual species

9 belonged to genus Streptomyces, followed by Nocardia and Kribbella.

10 m the Corynebacterium genus, 1 each from the Nocardia and Rhodococcus genera).

11 hiolactone antibiotic produced by species of Nocardia and Streptomyces, is an inhibitor of the beta-k

12 o the genera Mycobacterium, Corynebacterium, Nocardia and Streptomyces.

13 lowed the recognition of many new species of Nocardia and to date have been the most precise methods

14 d to Staphylococcus, Burkholderia, Serratia, Nocardia, and Aspergillus.

15 order Corynebacterineae (e.g., mycobacteria, nocardia, and rhodococci) share a glycolipid-rich cell w

16 presentative Mycobacterium, Corynebacterium, Nocardia, and Rhodococcus species.

17 tative isolates of the drug pattern types of Nocardia asteroides (except for N. asteroides drug patte

18 Nocardia asteroides accounts for most transplant-related

19 l and included all the isolates belonging to Nocardia asteroides complex antibiogram type IV.

20 dent with the unofficial species designation Nocardia asteroides complex antimicrobial susceptibility

21 or the in vitro susceptibility testing of 26 Nocardia asteroides complex isolates to the following an

22 patterns were seen with Gordona bronchialis, Nocardia asteroides complex type VI, Nocardia otitidisca

23 st clinically significant species within the Nocardia asteroides complex.

24 , DNA-DNA hybridization results confirm that Nocardia asteroides drug pattern type VI, which has long

25 The interactions of Nocardia asteroides GUH-2 with pulmonary epithelial cell

26 The adherence of Nocardia asteroides in the murine brain and lungs was de

27 Nocardia asteroides was isolated after prolonged culture

28 ia thailandica is a rare pathogen related to Nocardia asteroides, Nocardia neocaledoniensis, and Noca

29 xonomic history; this is especially true for Nocardia asteroides, the type species of the genus and p

30 ion of the murine lung by log-phase cells of Nocardia asteroides.

31 subsequent clearance of the infectious agent Nocardia asteroides.

32 irectly test this, mice were inoculated with Nocardia asteroides.

33 ii pneumonia, infection with Cryptococcus or Nocardia, bacterial pneumonia, viral pneumonia, and Kapo

34 Here we describe the first reported case of Nocardia beijingensis infection in the United States, ma

35 ied a candidate beta-lactone synthetase from Nocardia brasiliensis and reconstituted the biosynthetic

36 r most transplant-related nocardiosis, while Nocardia brasiliensis rarely causes infection in organ t

37 Toxoplasma gondii, Streptococcus pneumoniae, Nocardia brasiliensis, measles virus and cytomegalovirus

38 h microdilution testing on single strains of Nocardia brasiliensis, Nocardia cyriacigeorgica, Nocardi

39 a asteroides, Nocardia neocaledoniensis, and Nocardia caishijiensis that, since its original descript

40 In our cohort, PCR targeting Mucorales and Nocardia can improve the early detection of invasive pul

41 Coexpression of Nocardia Car and PPTase in E. coli gave a reductase with

42 bating purified recombinant Car with CoA and Nocardia cell-free extracts indicated that post-translat

43 retrospective molecular screening of recent Nocardia clinical isolates at our New York City medical

44 The type strains of three Nocardia species, Nocardia concava, Nocardia ignorata, and Nocardia yamana

45 Whole cells of Nocardia corallina B-276 catalyse the stereoselective ep

46 Nocardia corallina B-276 possesses a constitutive multi-

47 lkanes) by the alkene-utilizing actinomycete Nocardia corallina B276 was investigated.

48 lase system was purified to homogeneity from Nocardia corallina B276, a bacterium phylogenetically un

49 (AMO) from Rhodococcus rhodochrous (formerly Nocardia corallina) B-276 is a three-component enzyme sy

50 tinomycete Rhodococcus rhodochrous (formerly Nocardia corallina) B276.

51 tients enrolled in the trial, 55 (11%) had a Nocardia corneal ulcer.

52 Nocardia cyriacigeorgica has recently been described as

53 Nocardia cyriacigeorgica is recognized as an emerging pa

54 We describe an outbreak of Nocardia cyriacigeorgica soft-tissue infections attribut

55 on single strains of Nocardia brasiliensis, Nocardia cyriacigeorgica, Nocardia farcinica, Nocardia n

56 ports of sulfonamide failure in treatment of nocardia disease.

57 The visual outcome in Nocardia endophthalmitis is very guarded when presenting

58 d 25 eyes of 25 patients with culture-proven Nocardia endophthalmitis.

59 Patients with non-Nocardia etiology and those that were culture negative w

60 >=1 PCR targeting Aspergillus, Mucorales, or Nocardia (Eurofins-Viracor, KS) were reviewed.

61 tion of 2 isolates, Enterococcus faecium and Nocardia exalbida, all the other 725 (99.7%) gram-positi

62 t a 2.8- angstrom cocrystal structure of the Nocardia farcinica ileS T-box in complex with its cognat

63 Nocardia farcinica is the most clinically significant sp

64 ochemical and structural characterization of Nocardia farcinica Lys monooxygenase (NbtG), which has s

65 Although Nocardia farcinica surgical site infection outbreaks hav

66 Nocardia farcinica was more frequently associated with b

67 Nocardia farcinica was the most common among molecularly

68 ing the IcmFs from Geobacillus kaustophilus, Nocardia farcinica, and Burkholderia xenovorans.

69 Mycobacterium genomes, Rhodococcus sp. RHA1, Nocardia farcinica, and Saccharopolyspora erythraea.

70 didatus Pelagibacter ubique, actinobacterium Nocardia farcinica, chlorobi species Chloroherpeton thal

71 rdia brasiliensis, Nocardia cyriacigeorgica, Nocardia farcinica, Nocardia nova, and Nocardia wallacei

72 , we report crystal structures of RIFMO from Nocardia farcinica, the determination of the oligomeric

73 oxazole and the lack of quality controls for Nocardia for these agents.

74 ent susceptibilities of clinical isolates of Nocardia from six major laboratories in the United State

75 olates could not be characterized beyond the Nocardia genus level.

76 A gene sequencing and phenotypic analysis as Nocardia higoensis, an opportunistic organism isolated o

77 significant reduction in viral, fungal, and Nocardia IEps after heart transplantation was observed,

78 of three Nocardia species, Nocardia concava, Nocardia ignorata, and Nocardia yamanashiensis, which al

79 introduced as a new environmental species of Nocardia in 2004.

80 e presentation, diagnosis, and management of Nocardia in the modern era.

81 GM-CSF production was induced by Nocardia in vitro, suggesting a causative role for anti-

82 this study was to identify risk factors for Nocardia infection after SOT and to describe the present

83 immunocompromised patients with disseminated Nocardia infection, our patient responded favorably to p

84 -dose cotrimoxazole was not found to prevent Nocardia infection.

85 wise unexplained disseminated/extrapulmonary Nocardia infections, anti-GM-CSF autoantibodies should b

86 atment with trimethoprim-sulfamethoxazole in Nocardia infections.

87 us spp. and non-Aspergillus spp. molds), and Nocardia infections.

88 advantage to their native hosts during human Nocardia infections.

89 ermediates, a carboxylic acid reductase from Nocardia iowensis and an alcohol dehydrogenase from Leif

90 Nocardia is an environmental pathogen with a predilectio

91 bility testing (AST) of clinical isolates of Nocardia is recommended to detect resistance to commonly

92 The gold standard result for each Nocardia isolate was established by a consensus of the r

93 all antimicrobial agents tested against all Nocardia isolates by all methods, the BACTEC radiometric

94 describe here a novel method for identifying Nocardia isolates by using sequence analysis of a portio

95 atories have allowed us to define a group of Nocardia isolates from clinical samples which resemble t

96 and precise method for the identification of Nocardia isolates than 16S rRNA gene sequencing.

97 Nocardia isolates that share the property of in vitro am

98 the importance of accurate identification of Nocardia isolates to the species level by integrated use

99 No single method could identify all Nocardia isolates to the species level; therefore, a com

100 16S rRNA gene sequences of 102 Nocardia isolates were analyzed using the Integrated Dat

101 A standardized study protocol, 150 Nocardia isolates, and NIH and OSU Nocardia MALDI-TOF MS

102 Patients with non-Nocardia keratitis and those having no topical antibioti

103 performed for subgroups of patients with non-Nocardia keratitis and those with no topical antibiotic

104 r 299 cultures submitted to the Mycobacteria/Nocardia Laboratory at the University of Texas Health Ce

105 Reference Laboratories and the Mycobacteria/Nocardia Laboratory at the University of Texas Health Sc

106 ation, and score interpretation, using three Nocardia libraries, the Bruker, National Institutes of H

107 Oerskovia spp. are gram-positive, Nocardia-like bacilli which inhabit the soil and rarely

108 ocol, 150 Nocardia isolates, and NIH and OSU Nocardia MALDI-TOF MS libraries were distributed to thre

109 Finally, supplementation of the Bruker Nocardia MALDI-TOF MS library with both the OSU and NIH

110 The genomes of 40 strains of Nocardia, most of which were associated with life-threat

111 and may coexist with bacterial (Legionella, Nocardia), mycobacterial, and fungal (Aspergillus, Histo

112 Cells of the Corynebacterium-Nocardia-Mycobacterium group of bacteria are surrounded

113 Nocardia neocaledoniensis was introduced as a new enviro

114 are pathogen related to Nocardia asteroides, Nocardia neocaledoniensis, and Nocardia caishijiensis th

115 nocompromised patients were characterized as Nocardia nova by biochemical and susceptibility testing

116 device infection and bacteremia caused by a Nocardia nova complex isolate.

117 Moreover, for all Nocardia nova isolates tested, ampicillin susceptibility

118 We describe the first case of Nocardia nova spondylodiscitis accompanied by a psoas ab

119 ttern was identical to that obtained for the Nocardia nova type strain.

120 A variant RFLP pattern for Nocardia nova was also observed.

121 Patterns typical of Nocardia nova were obtained with REA of an amplified por

122 ocardia cyriacigeorgica, Nocardia farcinica, Nocardia nova, and Nocardia wallacei.

123 ulcers that were central, deep or large, non-Nocardia, or classically invasive Pseudomonas aeruginosa

124 NotI from Nocardia otitidis-caviarum (recognition sequence 5'-GCGG

125 hialis, Nocardia asteroides complex type VI, Nocardia otitidiscaviarum, Nocardia transvalensis, and S

126 Molecular investigation of two Nocardia patient isolates showed unusual restriction fra

127 ic and clinical performance of Mucorales and Nocardia PCR.

128 Nocardia phosphopantetheine transferase (PPTase) express

129 When incubated with [(3)H]acetyl-CoA and Nocardia PPTase, the labeled acetylphosphopantetheine mo

130 ncreasing in vitro sulfonamide resistance in Nocardia prompted us to investigate the findings.

131 A total of 85 strains of Nocardia representing five species were used in the stud

132 Of the nocardioforms examined, Nocardia, Rhodococcus, and Mycobacteria spp. all produce

133 , natural products isolated from a strain of Nocardia, showed growth inhibition against three human t

134 The protein sequence of the Nocardia sp NAD(P)-dependent cholesterol dehydrogenase r

135 n = 3), Mycobacterium avium complex (n = 2), Nocardia sp. (n = 1), Aspergillus sp. (n = 1), or pulmon

136 lator that was originally misidentified as a Nocardia sp. due, in part, to its partially acid-fast st

137 y 50-fold lower than that of purified native Nocardia sp. enzyme.

138 An aryl aldehyde oxidoreductase from Nocardia sp. strain NRRL 5646 was purified 196-fold by a

139 polymorphism (RFLP) patterns were found for Nocardia sp. type strains (except for the N. asteroides

140 sed as a quality control organism for AST of Nocardia sp., and the use of a disk diffusion test for s

141 A standard dose (SD) of Rhodococcus equi, Nocardia sp., M. nonchromogenicum, M. monacense, M. intr

142 The SD of R. equi, Nocardia sp., M. nonchromogenicum, M. monacense, M. intr

143 udomonas aeruginosa (109 cases [22.7%]), and Nocardia species (55 cases [11.5%]).

144 hniques for the identification of pathogenic Nocardia species and for the recognition of novel specie

145 Nocardia species are a complex group of organisms consid

146 orithms for the phenotypic identification of Nocardia species are limited in practice, the true preva

147 All isolates were identified as Nocardia species by the use of standard methods.

148 Nocardia species cause infections in both immunocompromi

149 A study was performed to evaluate Nocardia species identification obtained by partial 16S

150 Infection with Nocardia species is an increasingly recognized complicat

151 evaluation of 297 mycobacteria isolates, 148 Nocardia species isolates, and 61 other aerobic actinomy

152 as sequenced from 40 clinical isolates of 12 Nocardia species previously identified by 16S rRNA gene

153 Molecular methods for identification of Nocardia species provide more accurate and rapid results

154 ight mass spectrometry for identification of Nocardia species remains challenging.

155 Sequencing of Nocardia species revealed that members of the group were

156 to devise a method for the identification of Nocardia species that is more technically simple, accura

157 ble with identification of Mycobacterium and Nocardia species using matrix-assisted laser desorption

158 ecA1 gene of 30 type or reference strains of Nocardia species was amplified using secA1-specific prim

159 Molecular diagnosis of Nocardia species was performed using multilocus sequence

160 1 patient had a positive result by culture (Nocardia species) but negative result by qPCR.

161 162 Mycobacterium species and subspecies, 53 Nocardia species, and 13 genera (totaling 43 species) of

162 lococcus aureus, certain gram-negative rods, Nocardia species, and fungi.

163 g isolates, including Mycobacterium species, Nocardia species, and other aerobic actinomycetes) showe

164 The type strains of three Nocardia species, Nocardia concava, Nocardia ignorata, a

165 olates encompassing the 8 medically relevant Nocardia species.

166 verified in cultures of two patient-derived Nocardia species.

167 bcutaneous tissue infections than were other Nocardia species.

168 biotic susceptibility of clinically isolated Nocardia species.

169 es in bacterial corneal ulcers not caused by Nocardia species.

170 eproducible method for the identification of Nocardia spp.

171 g thiolactomycin (TLM), which is produced by Nocardia spp.

172 rapid identification of clinically relevant Nocardia spp. and to implement MALDI-TOF MS libraries de

173 Nocardia spp. are common environmental organisms that, t

174 n many species and that many taxa within the Nocardia spp. are unnamed at present.

175 y for the identification of mycobacteria and Nocardia spp. has also been reported in a limited scope.

176 cal workup of pericardial fluid for possible Nocardia spp. is described in an effort to improve the t

177 onella spp., 78 systemic dimorphic fungi, 69 Nocardia spp., and 57 protozoan parasites) comprised 675

178 This multicenter study analyzed Nocardia spp., including extraction, spectral acquisitio

179 In both E. coli and Nocardia spp., the glycolipid was only detected in cultu

180 equence typing sequence data for determining Nocardia strain relatedness in an outbreak.

181 Several Nocardia strains associated with nocardiosis, a potentia

182 of this polyketide biosynthetic pathway for Nocardia strains capable of infecting human hosts.

183 ative role for anti-GM-CSF autoantibodies in Nocardia susceptibility and dissemination.

184 dy of treatment strategies based on specific Nocardia syndromes is warranted.

185 including a wound culture that contained two Nocardia taxa that were indistinguishable morphologicall

186 lates that distinguished them from all other Nocardia taxa, but did not differentiate the four taxa w

187 vely, and differentiated them from all other Nocardia taxa.

188 Nocardia tends to affect individuals with chronic lung d

189 rt a case of pulmonary nocardiosis caused by Nocardia thailandica in a 66-year-old solid organ transp

190 Nocardia thailandica is a rare pathogen related to Nocar

191 Five clinical isolates of Nocardia that showed ambiguous bases within the variable

192 olymorphism (RFLP) identification schema for Nocardia that used an amplified 439-bp segment (amplicon

193 rRNA gene sequences of different species of Nocardia, those laboratories employing molecular methods

194 Identification of clinical isolates of Nocardia to the species level is important for defining

195 Identification of Nocardia to the species level is useful for predicting a

196 are grouped together by some authors in the Nocardia transvalensis complex.

197 complex type VI, Nocardia otitidiscaviarum, Nocardia transvalensis, and Streptomyces spp.

198 However, the sequences of Nocardia transvalensis, N. otitidiscaviarum, and N. nova

199 ythritol and ribitol and were grouped within Nocardia transvalensis.

200 py, accounting for response and tolerance of Nocardia treatment.

201 A regression model including a Nocardia-treatment arm interaction found corticosteroid

202 dentified by treatment for scar size for non-Nocardia ulcers (-0.06 mm, 95% CI, -0.21 to 0.10, P = .4

203 n BSCVA at 12 months among patients with non-Nocardia ulcers (-0.10 logMAR, 95% CI, -0.19 to -0.02, P

204 ifference was observed in 12-month BSCVA for Nocardia ulcers (0.18 logMAR, 95% CI, -0.04 to 0.41, P =

205 provement in visual acuity compared with non-Nocardia ulcers (0.21 logarithm of the minimal angle of

206 ith larger mean scar size at 12 months among Nocardia ulcers (0.47 mm, 95% CI, 0.06-0.88, P = .02) an

207 presentation visual acuity compared with non-Nocardia ulcers (median Snellen visual acuity, 20/45, co

208 Nocardia ulcers had approximately 2 lines less of improv

209 Patients with Nocardia ulcers had better presentation visual acuity co

210 Nocardia ulcers responded well to treatment.

211 verall improvement in visual acuity than non-Nocardia ulcers, but had better presentation acuity.

212 In Nocardia ulcers, corticosteroids were associated with an

213 tter starting visual acuity in patients with Nocardia ulcers.

214 transferase was cloned from a sublibrary of Nocardia uniformis DNA.

215 c gene cluster for the nocardicin A producer Nocardia uniformis subsp. tsuyamanensis ATCC 21806 was r

216 tam antibiotics produced by the actinomycete Nocardia uniformis subsp. tsuyamanensis ATCC 21806.

217 c beta-lactam isolated from the actinomycete Nocardia uniformis that shows moderate antibiotic activi

218 c beta-lactam isolated from the actinomycete Nocardia uniformis, which shows moderate activity agains

219 Nocardia veterana is a newly described species named aft

220 al samples which resemble the type strain of Nocardia veterana.

221 characteristics of the proposed new species Nocardia wallacei (N. asteroides drug pattern IV) and N.

222 gica, Nocardia farcinica, Nocardia nova, and Nocardia wallacei.

223 GM-CSF-mediated cellular activation by Nocardia was assessed by staining for intracellular cyto

224 Nocardia was cultured from all affected sites.

225 Linezolid also covers Nocardia well and could be a second line agent.

226 s, Gordonia, and Tsukamurella and 10 taxa of Nocardia were studied.

227 rovide background on the current taxonomy of Nocardia, with a focus on clinically relevant species, a

228 es, Nocardia concava, Nocardia ignorata, and Nocardia yamanashiensis, which also showed ambiguous bas