ライフサイエンスコーパス: O(6)-methylguanine-DNA methyltransferase

1 cosylase, Nth protein (endonuclease III) and O6-methylguanine-DNA methyltransferase.

2 ne S-transferase P1, and the DNA repair gene O6-methylguanine-DNA-methyltransferase.

3 ould be attributed to the down-regulation of O(6)-methylguanine-DNA methyltransferase activity.

4 uclease protein resulted in the retention of O6-methylguanine DNA methyltransferase activity but loss

5 These results demonstrate that the fusion of O6-methylguanine DNA methyltransferase and apurinic endo

6 MGMT (O(6)-methylguanine DNA methyltransferase) and APNG (alky

7 ELF3, c-Jun, Rb2/p130, JAK1, p67phox, Grb2, O(6)-methylguanine-DNA methyltransferase, and Ercc-1.

8 udied: 27% (26/95) at p16, 33% (31 of 95) at O6-methylguanine-DNA-methyltransferase; and 18% (17 of 9

9 of the apurinic endonuclease portion of the O6-methylguanine DNA methyltransferase-apurinic endonucl

10 tructed a human fusion protein consisting of O6-methylguanine DNA methyltransferase coupled with an a

11 ges in molecules involved in DNA repair (eg, O6-methylguanine-DNA methyltransferase, DNA topoisomeras

12 ve DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C. 2.1.1.63, M

13 ructure-function information about the human O6-methylguanine-DNA methyltransferase (EC 2.1.1.63), as

14 ctional 39 kDa Escherichia coli Ada protein (O6-methylguanine-DNA methyltransferase) (EC 2.1.1.63), p

15 INT1 (methylated in tumor 1), MINT2, MINT31, O(6)-methylguanine-DNA methyltransferase gene, and hMLH1

16 ion that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), hi

17 or radiotherapy alone, with consideration of O6-methylguanine-DNA-methyltransferase gene (MGMT) promo

18 ion-specific PCR and included: p16 (CDKN2A), O6-methylguanine-DNA-methyltransferase, glutathione S-tr

19 DNA repair enzymes, DNA polymerase beta and O6-methylguanine-DNA methyltransferase, have been shown

20 of hepatocyte growth factor or unmethylated O(6)-methylguanine-DNA methyltransferase may benefit fro

21 s of GBM, including age, performance status, O6-methylguanine-DNA methyltransferase methylation, and

22 work showed that, in addition to changes in O(6)-methylguanine DNA methyltransferase (MGMT) activity

23 itative measurement of alkylation repair via O(6)-methylguanine DNA methyltransferase (MGMT) and base

24 O(6)-methylguanine DNA methyltransferase (MGMT) suppress

25 en used in this study to specifically target O(6)-methylguanine DNA methyltransferase (MGMT) to the m

26 oviral-mediated delivery of the P140K mutant O(6)-methylguanine-DNA methyltransferase (MGMT(P140K)) i

27 er, gliomas expressing the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) are resi

28 of the p16(INK4a) tumor suppressor gene and O(6)-methylguanine-DNA methyltransferase (MGMT) DNA repa

29 Patients with unmethylated O(6)-methylguanine-DNA methyltransferase (MGMT) fare wor

30 Expression of the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) in tumor

31 O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA

32 O(6)-methylguanine-DNA methyltransferase (MGMT) is an en

33 ine tumors (NETs) when the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) is inact

34 O(6)-methylguanine-DNA methyltransferase (MGMT) methylat

35 to elevated expression of the repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) or a def

36 Tumor tissue was assayed to determine O(6)-methylguanine-DNA methyltransferase (MGMT) promoter

37 O(6)-methylguanine-DNA methyltransferase (MGMT) repairs

38 O(6)-Methylguanine-DNA methyltransferase (MGMT) status,

39 The methylation status of the promoter of O(6)-methylguanine-DNA methyltransferase (MGMT) was asse

40 O(6)-Methylguanine-DNA methyltransferase (MGMT)(1), a ub

41 in the context of the targeted knockdown of O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA r

42 We have previously shown that O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA r

43 d and stabilized methyltransferases, chiefly O(6)-methylguanine-DNA methyltransferase (MGMT), a key e

44 or aberrant promoter methylation of the p16, O(6)-methylguanine-DNA methyltransferase (MGMT), death-a

45 n version of the DNA damage reversal protein O(6)-methylguanine-DNA methyltransferase (MGMT), which p

46 also required for the cytotoxic response of O(6)-methylguanine-DNA methyltransferase (MGMT)-deficien

47 atients with microsatellite-stable (MSS) and O(6)-methylguanine-DNA methyltransferase (MGMT)-silenced

48 irect reversal mechanism by a protein termed O(6)-methylguanine-DNA methyltransferase (MGMT).

49 in the normal cell by the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT).

50 HCT116 and HCT15 cells that highly express O(6)-methylguanine-DNA-methyltransferase (MGMT) displaye

51 ward tumors that lack the DNA repair protein O(6)-methylguanine-DNA-methyltransferase (MGMT), which r

52 h the latter fused to the DNA repair protein O(6)-methylguanine-DNA-methyltransferase (MGMT).

53 t increased levels of the DNA repair protein O6 methylguanine-DNA methyltransferase (MGMT), also refe

54 The human DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) dealkylate

55 tin structure in the CpG island of the human O6-methylguanine DNA methyltransferase (MGMT) gene.

56 etinoic acid receptor-beta2 (RAR-beta2), and O6-methylguanine DNA methyltransferase (MGMT) genes were

57 O6-methylguanine DNA methyltransferase (MGMT) is a DNA r

58 of the gene encoding the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) might be r

59 ow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein th

60 The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes al

61 O6-Methylguanine DNA methyltransferase (MGMT) removes al

62 O6-Methylguanine DNA methyltransferase (MGMT) repairs th

63 tal carcinogens and the protective effect of O6-methylguanine DNA methyltransferase (MGMT), heterozyg

64 etection of four different proteins, avidin, O6-methylguanine DNA methyltransferase (MGMT), SNAP-tag,

65 complished in mammalian cells by the protein O6-methylguanine DNA methyltransferase (MGMT).

66 O6-methylguanine-DNA methyltransferase (MGMT [OMIM 15656

67 Pretreatment leukemia cell O6-methylguanine-DNA methyltransferase (MGMT) activity,

68 ith a vector containing or lacking the human O6-methylguanine-DNA methyltransferase (MGMT) cDNA.

69 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) confers re

70 h-level expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) correlates

71 O6-methylguanine-DNA methyltransferase (MGMT) functions

72 The O6-methylguanine-DNA methyltransferase (MGMT) gene methy

73 The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits t

74 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is a major

75 The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonl

76 The mechanism whereby the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is silence

77 rolonged survival, but only in patients with O6-methylguanine-DNA methyltransferase (MGMT) promoter m

78 ed methylation data from a CpG island in the O6-methylguanine-DNA methyltransferase (MGMT) promoter.

79 nation in the disposition of the inactivated O6-methylguanine-DNA methyltransferase (MGMT) protein in

80 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes mu

81 O6-methylguanine-DNA methyltransferase (MGMT) reverses a

82 ut suppressed methylation at the promoter of O6-methylguanine-DNA methyltransferase (MGMT) to enhance

83 O6-Methylguanine-DNA methyltransferase (MGMT), a constit

84 O6-methylguanine-DNA methyltransferase (MGMT), a ubiquit

85 O6-Methylguanine-DNA methyltransferase (MGMT), a ubiquit

86 O6-Methylguanine-DNA methyltransferase (MGMT), an enzyme

87 This lesion is repaired by O6-methylguanine-DNA methyltransferase (MGMT), the expre

88 rivatives is countered by the repair protein O6-methylguanine-DNA methyltransferase (MGMT), which rem

89 O6-MeG, a DNA lesion repaired by the protein O6-methylguanine-DNA methyltransferase (MGMT).

90 ese mechanisms may be the high expression of O6-methylguanine-DNA methyltransferase (MGMT).

91 as the P140K mutant of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT*).

92 essor gene p16 (CDKN2A), the DNA repair gene O6-methylguanine-DNA-methyltransferase (MGMT) and the pu

93 These include the importance of O6-methylguanine-DNA-methyltransferase (MGMT) in gliobla

94 r of metalloproteinase 3 (TIMP-3), p16INK4a, O6-methylguanine-DNA-methyltransferase (MGMT), death-ass

95 O6-methylguanine-DNA-methyltransferase (MGMT), which rep

96 uced cells in vivo, selection based on P140K O6-methylguanine-DNA-methyltransferase (MGMT[P140K]) gen

97 yposis coli, APC; mut-L homolog 1, MLH1; and O(6)-methylguanine-DNA methyltransferase, MGMT) by liqui

98 vels of MET ligand hepatocyte growth factor, O(6)-methylguanine-DNA methyltransferase promoter methyl

99 TV a prolonged OS (P = 0.005) independent of O(6)-methylguanine-DNA-methyltransferase promoter methyl

100 ariate analysis, the factors age, WHO grade, O6-methylguanine-DNA methyltransferase promoter methylat

101 ed glioblastoma that harbors a nonmethylated O(6)-methylguanine-DNA methyltransferase promotor, stand

102 D-54 tumors, which do not express measurable O(6)-methylguanine-DNA methyltransferase protein, is pro

103 id anchors capable of covalent attachment to O(6)-methylguanine DNA methyltransferase (SNAP-tag) fusi

104 wed prognostic significance, with WHO grade, O6-methylguanine-DNA methyltransferase status, age, and

105 some methylated bases from DNA, and suicidal O(6)-methylguanine-DNA methyltransferases to transfer al

106 Patients with newly diagnosed O(6)-methylguanine-DNA methyltransferase-unmethylated gl

107 been identified in GBMs, except for loss of O(6-)methylguanine-DNA methyltransferase via promoter me

108 The percentage of patients methylated at O(6)-methylguanine-DNA methyltransferase was lower than